Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B: Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet. 2012, 380: 37-43. 10.1016/S0140-6736(12)60240-2. doi:10.1016/S0140-6736(12)60240-2
Article
PubMed
Google Scholar
Valderas JM, Starfield B, Sibbald B, Salisbury C, Roland M: Defining comorbidity: implications for understanding health and health services. Ann Fam Med. 2009, 7: 357-363. 10.1370/afm.983. doi:10.1370/afm.983
Article
PubMed
PubMed Central
Google Scholar
May C, Montori VM, Mair FS: We need minimally disruptive medicine. BMJ. 2009, 339: b2803-10.1136/bmj.b2803.
Article
PubMed
Google Scholar
Hughes LD, McMurdo MET, Guthrie B: Guidelines for people not for diseases: the challenges of applying UK clinical guidelines to people with multimorbidity. Age Ageing. 2013, 42: 62-69. 10.1093/ageing/afs100.
Article
PubMed
Google Scholar
Eton DT, Ramalho-de Oliveira D, Egginton JS, Ridgeway JL, Odell L, May CR, Montori VM: Building a measurement framework of burden of treatment in complex patients with chronic conditions: a qualitative study. Patient Relat Outcome Meas. 2012, 3: 39-49. 10.2147/PROM.S34681.
Article
PubMed
PubMed Central
Google Scholar
Gallacher K, May C, Montori VM, Mair FS: Understanding treatment burden in chronic heart failure patients: a qualitative study. Ann Fam Med. 2011, 9: 235-243. 10.1370/afm.1249.
Article
PubMed
PubMed Central
Google Scholar
Tran VT, Montori VM, Eton DT, Baruch D, Falissard B, Ravaud P: Development and description of measurement properties of an instrument to assess treatment burden among patients with multiple chronic conditions. BMC Med. 2012, 10: 68-10.1186/1741-7015-10-68.
Article
PubMed
PubMed Central
Google Scholar
Jani B, Blane D, Browne S, Montori VM, May CR, Shippee ND, Mair FS: Identifying treatment burden as an important concept for end of life care in those with advanced heart failure. Curr Opin Support Palliat Care. 2013, 7: 3-7. 10.1097/SPC.0b013e32835c071f. doi:10.1097/SPC.0b013e32835c071f
Article
PubMed
Google Scholar
Shippee ND, Shah ND, May CR, Mair FS, Montori VM: Cumulative complexity: a functional, patient-centered model of patient complexity can improve research and practice. J Clin Epidemiol. 2012, 65: 1041-1051. 10.1016/j.jclinepi.2012.05.005. doi:10.1016/j.jclinepi.2012.05.005
Article
PubMed
Google Scholar
Vik SA, Maxwell CJ, Hogan DB: Measurement, correlates, and health outcomes of medication adherence among seniors. Ann Pharmacother. 2004, 38: 303-312. 10.1345/aph.1D252. doi:312.10.1345/aph.1D252
Article
PubMed
Google Scholar
Eton DT, Elraiyah TA, Yost KJ, Ridgeway JL, Johnson A, Egginton JS, Mullan RJ, Murad MH, Erwin PJ, Montori VM: A systematic review of patient-reported measures of burden of treatment in three chronic diseases. Patient Relat Outcome Meas. 2013, 4: 7-20. 10.2147/PROM.S44694.
Article
PubMed
PubMed Central
Google Scholar
Calderon-Larranaga A, Poblador-Plou B, Gonzalez-Rubio F, Gimeno-Feliu LA, Abad-Diez JM, Prados-Torres A: Multimorbidity, polypharmacy, referrals, and adverse drug events: are we doing things well?. Br J Gen Pract. 2012, 62: e821-e826. 10.3399/bjgp12X659295. doi:10.3399/bjgp12X659295
Article
PubMed
PubMed Central
Google Scholar
Sehgal V, Bajwa SJ, Sehgal R, Bajaj A, Khaira U, Kresse V: Polypharmacy and potentially inappropriate medication use as the precipitating factor in readmissions to the hospital. J Fam Med Prim Care. 2013, 2: 194-199. 10.4103/2249-4863.117423. doi:10.4103/2249-4863.117423
Article
Google Scholar
Duerden M, Avery T, Payne R: Polypharmacy and Medicines Optimisation: Making It Safe and Sound. [http://www.kingsfund.org.uk/publications/polypharmacy-and-medicines-optimisation]
Fulton MM, Riley Allen E: Polypharmacy in the elderly: a literature review. J Am Assoc Nurse Pract. 2005, 17: 123-132. 10.1111/j.1041-2972.2005.0020.x.
Article
Google Scholar
Hajjar ER, Cafiero AC, Hanlon JT: Polypharmacy in elderly patients. Am J Geriatr Pharmacother. 2007, 5: 345-351. 10.1016/j.amjopharm.2007.12.002. doi:10.1016/j.amjopharm.2007.12.002
Article
PubMed
Google Scholar
Viktil KK, Blix HS, Moger TA, Reikvam A: Polypharmacy as commonly defined is an indicator of limited value in the assessment of drug-related problems. Br J Clin Pharmacol. 2007, 63: 187-195. 10.1111/j.1365-2125.2006.02744.x. doi:10.1111/j.1365-2125.2006.02744.x
Article
PubMed
Google Scholar
Avery AJ, Barber N, Ghaleb M, Franklin BD, Armstrong S, Crowe S, Dhillon S, Freyer A, Howard R, Pezzolesi C, Serumaga B, Swanwick G, Talabi O: Investigating the Prevalence and Causes of Prescribing Errors in General Practice: The PRACtICe Study. GMC Publication; 2012:1-5.
Payne RA, Avery AJ, Duerden M, Saunders CL, Simpson CR, Abel GA: Prevalence of polypharmacy in a Scottish primary care population.Eur J Clin Pharmacol 2014, doi:10.1007/s00228-013-1639-9.
Lehnert T, Heider D, Leicht H, Heinrich S, Corrieri S, Luppa M, Riedel-Heller S, Konig HH: Review: health care utilization and costs of elderly persons with multiple chronic conditions. Med Care Res Rev. 2011, 68: 387-420. 10.1177/1077558711399580. doi:10.1177/1077558711399580
Article
PubMed
Google Scholar
Taylor AW, Price K, Gill TK, Adams R, Pilkington R, Carrangis N, Shi Z, Wilson D: Multimorbidity - not just an older person’s issue. Results from an Australian biomedical study. BMC Public Health. 2010, 10: 718-10.1186/1471-2458-10-718. doi:10.1186/1471-2458-10-718
Article
PubMed
PubMed Central
Google Scholar
Muggah E, Graves E, Bennett C, Manuel DG: The impact of multiple chronic diseases on ambulatory care use; a population based study in Ontario, Canada. BMC Health Serv Res. 2012, 12: 452-10.1186/1472-6963-12-452. doi:10.1186/1472-6963-12-452
Article
PubMed
PubMed Central
Google Scholar
Gallacher K, Morrison D, Jani B, Macdonald S, May CR, Montori VM, Erwin PJ, Batty GD, Eton DT, Langhorne P, Majeed A: Uncovering treatment burden as a key concept for stroke care: a systematic review of qualitative research.PLoS Med 2013, 10 doi:10.1371/journal.pmed.1001473.
Foley N, McClure JA, Meyer M, Salter K, Bureau Y, Teasell R: Inpatient rehabilitation following stroke: amount of therapy received and associations with functional recovery. Disabil Rehabil. 2012, 34: 2132-2138. 10.3109/09638288.2012.676145.
Article
PubMed
Google Scholar
Chatterjee P, Cucchiara BL, Lazarciuc N, Shofer FS, Pines JM: Emergency department crowding and time to care in patients with acute stroke. Stroke. 2011, 42: 1074-1080. 10.1161/STROKEAHA.110.586610.
Article
PubMed
Google Scholar
O’Carroll R, Whittaker J, Hamilton B, Johnston M, Sudlow C, Dennis M: Predictors of adherence to secondary preventive medication in stroke patients. Ann Behav Med. 2011, 41: 383-390. 10.1007/s12160-010-9257-6.
Article
PubMed
Google Scholar
Ostwald SK, Wasserman J, Davis S: Medications, comorbidities, and medical complications in stroke survivors: The CAReS study. Rehabil Nurs. 2006, 31: 10-14. 10.1002/j.2048-7940.2006.tb00004.x.
Article
PubMed
PubMed Central
Google Scholar
Berlowitz DR, Hoenig H, Cowper DC, Duncan PW, Vogel WB: Impact of comorbidities on stroke rehabilitation outcomes: does the method matter?. Arch Phys Med Rehabil. 2009, 89: 1903-1906. 10.1016/j.apmr.2008.03.024.
Article
Google Scholar
Goldstein LB, Samsa GP, Matchar DB, Horner RD: Charlson Index comorbidity adjustment for ischaemic stroke outcome studies. Stroke. 2004, 35: 1941-1945. 10.1161/01.STR.0000135225.80898.1c.
Article
PubMed
Google Scholar
van Baal P, Engelfriet P, Boshuizen H, van de Kassteele J, Schellevis F, Hoogenveen R: Co-occurrence of diabetes, myocardial infarction, stroke, and cancer: quantifying age patterns in the Dutch population using health survey data. Popul Health Metr. 2011, 9: 51-10.1186/1478-7954-9-51. doi:10.1186/1478-7954-9-51
Article
PubMed
PubMed Central
Google Scholar
Lui M, Domen K, Chino N: Comorbidity measures for stroke outcome research: a preliminary study. Arch Phys Med Rehabil. 1997, 78: 166-172. 10.1016/S0003-9993(97)90259-8.
Article
Google Scholar
Information Services Division Scotland: Stroke statistics update; 2014.], [http://www.isdscotland.org/Health-Topics/Stroke/Publications/2014-01-28/2014-01-28-Stroke-Report.pdf?65620058775]
Mizokami F, Koide Y, Noro T, Furuta K: Polypharmacy with common diseases in hospitalized elderly patients. Am J Geriatr Pharmacother. 2012, 10: 123-128. 10.1016/j.amjopharm.2012.02.003.
Article
PubMed
Google Scholar
Schmidt M, Jacobsen JB, Johnsen SP, Botker HE, Sorensen HT: Eighteen-year trends in stroke mortality and the prognostic influence of comorbidity. Neurology. 2014, 82: 340-350. 10.1212/WNL.0000000000000062. doi:10.1212/WNL.0000000000000062
Article
PubMed
Google Scholar
Zhu H, Hill MD: Stroke: the Elixhauser Index for comorbidity adjustment of in-hospital case fatality. Neurology. 2008, 71: 283-287. 10.1212/01.wnl.0000318278.41347.94. doi:10.1212/01.wnl.0000318278.41347.94
Article
PubMed
Google Scholar
Johansen HL, Wielgosz AT, Nguyen K, Fry RN: Incidence, comorbidity, case fatality and readmission of hospitalized stroke patients in Canada. Can J Cardiol. 2006, 22: 65-71. 10.1016/S0828-282X(06)70242-2.
Article
PubMed
PubMed Central
Google Scholar
Elder R, Kirkpatrick M, Ramsay W, MacLeod M, Guthrie B, Sutton M, Watt G: Measuring Quality in Primary Medical Services Using Data from SPICE. : Information and Statistics Division, NHS National Services Scotland; 2007.
Lis Y, Mann RD: The VAMP Research multi-purpose database in the UK. J Clin Epidemiol. 1995, 48: 431-443. 10.1016/0895-4356(94)00137-F.
Article
CAS
PubMed
Google Scholar
Carstairs V, Morris R: Deprivation and Health in Scotland. 1991, Aberdeen University Press, Aberdeen
Google Scholar
Diederichs C, Berger K, Bartels DB: The measurement of multiple chronic diseases-a systematic review on existing multimorbidity indices. J Gerontol A Biol Sci Med Sci. 2011, 66: 301-311. 10.1093/gerona/glq208. doi:10.1093/gerona/glq208
Article
PubMed
Google Scholar
Health and Social Care Information Centre: Quality and Outcomes Framework. [http://www.hscic.gov.uk/qof]
NHS Health Scotland: NHS Health Scotland. [], [http://www.healthscotland.com/resources/index.aspx]
Huntley AL, Johnson R, Purdy S, Valderas JM, Salisbury C: Measures of multimorbidity and morbidity burden for use in primary care and community settings: a systematic review and guide. Ann Fam Med. 2012, 10: 134-141. 10.1370/afm.1363. doi:10.1370/afm.1363
Article
PubMed
PubMed Central
Google Scholar
Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Magid D, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler ER, Moy CS, Mussolino ME, Nichol G, Paynter NP, Schreiner PJ, Sorlie PD, Stein J, Turan TN, Virani SS, Wong ND, Woo D, Turner MB: Heart disease and stroke statistics update: a report from the American Heart Association. Circulation. 2013, 127: e6-e245. 10.1161/CIR.0b013e31828124ad.
Article
PubMed
Google Scholar
National Institute for Health and Care Excellence (NICE): Stroke Rehabilitation: Long Term Rehabilitation After Stroke (CG162). : NICE; 2013.
Gandhi TK, Weingart SN, Borus J, Seger AC, Peterson J, Burdick E, Seger DL, Shu K, Federico F, Leape LL, Bates DW: Adverse drug events in ambulatory care. N Engl J Med. 2003, 348: 1556-1564. 10.1056/NEJMsa020703.
Article
PubMed
Google Scholar
Calderón-Larrañaga A, Gimeno-Feliu LA, González-Rubio F, Poblador-Plou B, Lairla-San José M, Abad-Diez JM, Prados-Torres A: Polypharmacy patterns: unravelling systematic associations between prescribed medications. PLoS One. 2013, 8: e84967-10.1371/journal.pone.0084967.
Article
PubMed
PubMed Central
Google Scholar
May CR, Eton DT, Boehmer K, Gallacher K, Hunt KJ, MacDonald S, Mair FS, May CM, Montori VM, Richardson A, Rogers AE, Shippee N: Rethinking the patient: using Burden of Treatment Theory to understand the changing dynamics of illness. BMC Health Serv Res. 2014, 14: 281-10.1186/1472-6963-14-281.
Article
PubMed
PubMed Central
Google Scholar
Wood JP, Connelly DM, Maly MR: “Holding me back”: living with arthritis while recovering from stroke. Arch Phys Med Rehabil. 2009, 90: 494-500. 10.1016/j.apmr.2008.08.224.
Article
PubMed
Google Scholar
Moroney JT, Tseng CL, Paik MC, Mohr JP, Desmond DW: Treatment for the secondary prevention of stroke in older patients: the influence of dementia status. J Am Geriatr Soc. 1999, 47: 824-829. 10.1111/j.1532-5415.1999.tb03839.x.
Article
CAS
PubMed
Google Scholar
Marcum ZA, Gellad WF: Medication adherence to multidrug regimens. Clin Geriatr Med. 2012, 28: 287-300. 10.1016/j.cger.2012.01.008. doi:10.1016/j.cger.2012.01.008
Article
PubMed
PubMed Central
Google Scholar
Tinetti M, Fried TR, Boyd CM: Designing health care for the most common chronic condition-multimorbidity. JAMA. 2012, 307: 2493-2494.
CAS
PubMed
PubMed Central
Google Scholar
U.S. Department of Health and Human Services: Multiple Chronic Conditions: A Strategic Framework Optimum Health and Quality of Life for Individuals with Multiple Chronic Conditions. U.S. Department of Health and Human Services; 2010.
Scottish Intercollegiate Guidelines Network: Management of Patients with Stroke: Rehabilitation, Prevention and Management of Complications, and Discharge Planning no 118. 2010. Available: Accessed 6th February 2013., [http://www.sign.ac.uk/guidelines/fulltext/118/index.html]
Canadian Stroke Network and the Heart and Stroke Foundation of Canada: Canadian Best Practice Recommendations for Stroke Care. ; 2010. ., [http://www.strokebestpractices.ca/]
Miller EL, Murray L, Richards L, Zorowitz RD, Bakas T, Clark P, Billinger SA: Comprehensive overview of nursing and interdisciplinary rehabilitation care of the stroke patient: a scientific statement from the American Heart Association. Stroke. 2010, 41: 2402-2448. 10.1161/STR.0b013e3181e7512b.
Article
PubMed
Google Scholar
United States Department of Veteran Affairs: Management of Stroke Rehabilitation. 2010. ., [http://www.healthquality.va.gov/guidelines/Rehab/stroke/]
Boyd CM, Darer J, Boult C, Fried LP, Boult L, Wu AW: Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: Implications for pay for performance. JAMA. 2005, 294: 716-724. 10.1001/jama.294.6.716. doi:10.1001/jama.294.6.716
Article
CAS
PubMed
Google Scholar
Guthrie B, Payne K, Alderson P, McMurdo MET, Mercer SW: Adapting clinical guidelines to take account of multimorbidity. BMJ. 2012, 345: e6341-10.1136/bmj.e6341.
Article
PubMed
Google Scholar
Stange KC: The generalist approach. Ann Fam Med. 2009, 7: 198-203. 10.1370/afm.1003.
Article
PubMed
PubMed Central
Google Scholar
Reeve J, Blakeman T, Freeman GK, Green LA, James PA, Lucassen P, Martin CM, Sturmberg JP, van Weel C: Generalist solutions to complex problems: generating practice-based evidence - the example of managing multi-morbidity. BMC Fam Pract. 2013, 14: 112-10.1186/1471-2296-14-112.
Article
PubMed
PubMed Central
Google Scholar
Stroke Association: Stroke Statistics. 2013. ., [http://www.stroke.org.uk/resource-sheet/stroke-statistics]