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Table 2 Main outcomes of the efficient scenarios

From: Trade-off between benefits, harms and economic efficiency of low-dose CT lung cancer screening: a microsimulation analysis of nodule management strategies in a population-based setting

Scenario Scenario characteristicsa Detected cancers at an early stage (I/II), % Reduction in lung cancer mortality, % Lung cancer deaths averted Discounted life years gained Interval cancer cases Overdiagnosed cases Overdiagnosis, % Discounted total cost, million euro Discounted additional costs vs no screening, million euro Cost per life years gained vs no screening (uniform discounting), euro Discounted cost per lung cancer death averted vs no screening, euro ICER vs the previous efficient scenario, euro
Efficient scenarios based on the cost per life year gained ratio
Scenario 65 55-75-40-10-NELSON-VDT300-none 67.31 9.95 14,373 133,222 23,057 6733 9.48 10,892 2232 16,754 155,287 16,754
Scenario 60 55-75-40-10-NELSON-VDT400-V300 71.35 12.38 17,889 164,864 19,854 17,892 9.69 11,516 2855 17,321 159,625 19,707
Scenario 41 50-75-15-9-NELSON-VDT400-V300 72.39 11.90 37,075 362,039 43,331 32,183 17.78 29,456 7556 20,870 203,792 23,804
Efficient scenarios based on the cost per averted lung cancer death ratio
Scenario 65 55-75-40-10-NELSON-VDT300-none 67.31 9.95 14,373 133,222 23,057 6733 9.48 10,892 2232 16,754 155,287 155,287
Scenario 64 55-75-40-10-NELSON-VDT400-none 67.95 10.65 15,395 140,490 21,367 9184 11.73 11,057 2397 17,059 155,675 161,124
Scenario 60 55-75-40-10-NELSON-VDT400-V300 71.35 12.38 17,889 164,864 19,854 17,892 19.69 11,516 2855 17,321 159,625 184,009
Scenario 22 55-80-30-15-NELSON-VDT400-V300 70.95 12.80 29,165 260,807 32,071 33,473 21.76 18,846 5296 20,307 181,597 216,454
Scenario 41 50-75-15-9-NELSON-VDT400-V300 72.39 11.90 37,075 362,039 43,331 32,183 17.78 29,456 7556 20,870 203,792 285,630
  1. aScenarios are named ranging these values as follows: ”population selection criteria-nodule management protocol-threshold values for growth rate and nodule size”