- Research article
- Open Access
Trade-off between benefits, harms and economic efficiency of low-dose CT lung cancer screening: a microsimulation analysis of nodule management strategies in a population-based setting
BMC Medicine volume 15, Article number: 162 (2017)
In lung cancer screening, a nodule management protocol describes nodule assessment and thresholds for nodule size and growth rate to identify patients who require immediate diagnostic evaluation or additional imaging exams. The Netherlands-Leuvens Screening Trial and the National Lung Screening Trial used different selection criteria and nodule management protocols. Several modelling studies have reported variations in screening outcomes and cost-effectiveness across selection criteria and screening intervals; however, the effect of variations in the nodule management protocol remains uncertain. This study evaluated the effects of the eligibility criteria and nodule management protocols on the benefits, harms and cost-effectiveness of lung screening scenarios in a population-based setting in Germany.
We developed a modular microsimulation model: a biological module simulated individual histories of lung cancer development from carcinogenesis onset to death; a screening module simulated patient selection, screening-detection, nodule management protocols, diagnostic evaluation and screening outcomes. Benefits included mortality reduction, life years gained and averted lung cancer deaths. Harms were costs, false positives and overdiagnosis. The comparator was no screening. The evaluated 76 screening scenarios included variations in selection criteria and thresholds for nodule size and growth rate.
Five years of annual screening resulted in a 9.7–12.8% lung cancer mortality reduction in the screened population. The efficient scenarios included volumetric assessment of nodule size, a threshold for a volume of 300 mm3 and a threshold for a volume doubling time of 400 days. Assessment of volume doubling time is essential for reducing overdiagnosis and false positives. Incremental cost-effectiveness ratios of the efficient scenarios were 16,754–23,847 euro per life year gained and 155,287–285,630 euro per averted lung cancer death.
Lung cancer screening can be cost-effective in Germany. Along with the eligibility criteria, the nodule management protocol influences screening performance and cost-effectiveness. Definition of the thresholds for nodule size and nodule growth in the nodule management protocol should be considered in detail when defining optimal screening strategies.
The National Lung Screening Trial (NLST) in the USA  has shown that lung screening with low-dose computed tomography (LDCT) can reduce lung cancer mortality by 20%, but it also can induce harms that the screened population may experience, i.e. false-positive findings, overdiagnosed cases, radiation-related deaths and interval cancers [2,3,4,5]. The largest lung screening trial in Europe, the Netherlands-Leuvens Screening Trial (NELSON) , used less stringent selection criteria and a different approach to patient management and has reported a reduced number of false positives compared to NLST . The nodule management protocols of NLST and NELSON differ in applied measurement techniques (diametric vs volumetric assessment), follow-up algorithms and the definition of a cut-off nodule size indicating a cancer-positive result . However, other differences between the studies (e.g. screened cohort, screening intervals) make it difficult to recognise the potential of nodule management approaches to succeed in the reduction of harms of screening.
Designing a screening program with an optimal balance between the benefits, harms and/or cost-effectiveness has become a major challenge for healthcare decision-makers who manage development of a lung screening program and decide on population selection strategies and screening intervals [7, 9, 10] as well as for clinicians who decide how to manage a screening-detected lung nodule .
Several modelling studies have examined trade-offs between the benefits and harms of LDCT screening and contributed to comprehension of the effects that eligibility criteria and screening intervals might have on its long-term screening performance and cost-effectiveness [11,12,13,14,15,16,17,18]. However, the effects of nodule management strategies have not been investigated in detail, and our understanding of how to proceed with a screening-detected nodule remains limited . An algorithm for nodule assessment and management determines ways to prognosticate malignancy, defines core procedures of a screening program and may strongly influence the screening outcomes .
In this modelling study, we aimed to investigate the effects of the eligibility criteria and nodule management on the benefits, harms and cost-effectiveness of lung screening with LDCT in a population-based setting.
We developed a stochastic modular microsimulation model that simulated individual life histories focusing on the development of lung cancer and its progression from the onset of the first malignant cell to death from lung cancer.
The model consists of the following structural modules: population, natural history, clinical detection, survival, screening and life history (Fig. 1). The model was populated with 10% of the German population aged 40 years and older. Data on smoking behaviour was obtained from the German Health Update (GEDA) survey (years 2009–2012) , and the demographic structure of 2012 was obtained from the German statistical office .
The natural history module contains a biological two-stage clonal expansion (TSCE) model  and a tumour growth component and simulates a complete flow of events in the development of lung cancer (details are available in Additional file 1: Section 1.1.2). The TSCE model defines the individual age at the onset of the first malignant cell and the histologic cancer type: small cell, large cell, squamous cell carcinoma, adenocarcinoma or adenocarcinoma in situ (AIS). The progression of lung cancer is described via tumour growth, lymph nodes involvement and metastasis. The tumour growth is defined by a Gompertz function  (Additional file 1: Section 184.108.40.206). This function describes the relation between time and the tumour volume. For a specific tumour volume the function gives the time needed to reach this volume and vice versa. The module uses the age at the onset of the first malignant cell and the time to reach the stage-specific volume and gives the age at different stages of the progression of the disease. Threshold tumour volumes at the stages of nodal involvement, distant metastases and clinical diagnosis are randomly drawn from log-normal distributions (Additional file 1: Table S5), and the tumour growth model is applied to calculate the corresponding ages of the individual. The clinical detection module determines the stage of lung cancer (I, II, III, IV) according to the tumour-node-metastasis (TNM) staging system based on the tumour volume and spread (local, nodal involvement, distant metastasis) at the age of diagnosis (Additional file 1: Section 1.1.3).
The lung cancer survival is modelled as long-term survival, which lets the individual live until death from other causes, and short-term survival in years, which follows the Weibull distribution . The parameters vary over the histological classes and stages at the time of diagnosis (Additional file 1: Table S1, Section 1.1.3) .
The screening module (Additional file 1: Section 1.1.5) contains several structural components: eligibility assessment, screening-detection, nodule management (including follow-up), diagnostic work-up and lung cancer survival. For each individual it creates a screening schedule based on eligibility criteria and nodule management protocol. At each screening exam, the module checks for presence of a lung nodule and determines its volume using the tumour growth function, the individual’s age and the age at the onset of the first malignant cell. Screening-detection depends on the location and volume of the tumour and the sensitivity of the CT scan (Additional file 1: Section 220.127.116.11, Table S7). Individuals with a detected nodule proceed with a nodule management algorithm. The nodule management algorithm defines the threshold values of the nodule size and tumour growth and indicates the patients who require immediate diagnostic work-up or undergo additional imaging exams (follow-up course).
Two nodule management algorithms were designed based on those used in the NELSON and NLST trials. Schematic representations of the algorithms are given in Figs. 2 and 3. The modelled NELSON-like nodule management algorithm includes volumetric assessment of the nodule size. Based on the nodule volume, the patients undergo either the next screening round (if negative), a follow-up exam 3 months later (if indeterminate) or an immediate diagnostic evaluation (if positive) [6, 26]. At the follow-up examination, tumour growth and tumour volume doubling time (VDT ) are assessed as an additional malignancy predictor.
The NLST-like nodule management algorithm includes diametric assessment of the nodule size and defines three categories of screening results: negative, positive intermediate and positive (Fig. 3). In contrast to the NELSON-like nodule management algorithm, individuals with positive intermediate initial results undergo a course of follow-up chest imaging exams where tumour growth is assessed as a change (%) in the nodule diameter relative to the result at the initial screening. The follow-up can occur with a fixed periodicity: at 3, 6 and 12 months after the initial screening. Additional details on the modelled nodule management protocols are available in Additional file 1: Section 18.104.22.168. Individuals with lung cancer, defined in the management algorithm, undergo the diagnostic work-up component (Additional file 1: Section 22.214.171.124), and the tumour is staged according to TNM classification based on the volume and spread. These patients are withdrawn from the regular screening schedule.
We assume that individuals with screen-detected lung cancer live at least as long as they would in the no screening scenario. In the screening module lung cancer, survival component alters the age of death from lung cancer for the persons with a screen-detected lung cancer at stages I and II: if they die from lung cancer in the no screening scenario, they receive 40% probability of long-term survival . The screening module sums up imaging exams, work-ups, complications and treatments. The life history module computes false positives and interval cancers and calculates overdiagnosed cases and deaths from radiation-induced cancer (Additional file 1: Section 1.1.6). Figure 4 gives a schematic representation of the modelling of the tumour growth and interaction between the natural history, screening, clinical diagnosis and survival modules.
At base case, a 5-year LDCT annual lung screening program with perfect adherence was evaluated. Overall, 76 scenarios were constructed using variations of the eligibility criteria (four different screened populations) and nodule management protocol (defined as the NELSON-like or NLST-like protocol) (Table 1). The outcomes were projected over the course of a lifetime. Lung cancer-specific mortality reduction and false-positive cases were calculated for the screened cohort.
Costs included LDCT exams, staging tests and lifetime treatment (Additional file 1: Table S8). Expenditures of lifetime treatment, due to limitations of available cost data for Germany, were calculated via application of cost variations across cancer stages obtained from the UK cost data  compared with the German cost data  (Additional file 1: Section 1.3). The lifetime treatment costs for patients with early-stage and advanced cancers were 45,803 euro for stages I/II and 30,101 euro for stages III/IV.
Cost-effectiveness was represented by average and incremental cost-effectiveness ratios (ACER and ICER, respectively). Life years gained (LYG) and averted lung cancer deaths constituted the main benefits of the screening. We applied equal (3%) and differential (3% for costs and 1.5% for LYG) annual discounting. A health insurance perspective was used.
One-way sensitivity analyses were performed to assess variations of the cost-effectiveness after altering assumptions about LDCT sensitivity parameters, parameters of long-term survival after screening, attendance rate cost per CT exam and lifetime treatment costs (Additional file 1: Section 1.4).
Benefits and harms of screening
Annual screening led to a 9.7–12.8% reduction in lung cancer mortality in the screened cohorts. Relative to usual care, where 79% of cancers were diagnosed at stages III and IV, a screening program shifted the majority of diagnoses towards the early-staged cancers (stages I/II accounted for 66.4–71.7%). Adenocarcinomas (around 50%), squamous cell carcinomas (around 23.4%) and AIS (around 18.2%) constituted the majority of screening-detected cancers. Around 77.2% of screening-diagnosed AIS were overdiagnosed cases. Overdiagnoses constituted 9–21.5% of all screening-detected lung cancers. Small cell carcinomas were rarely detected at screening (around 5.35%) but constituted 56% of all interval cancers. False-positive diagnoses constituted 59.4–96% of all screening findings.
Eligibility criteria have a considerable influence on the main outcomes of a large-scale screening program. Evaluated scenarios with a selection of people similar to the eligibility criteria of the NLST clinical trial (55-74-30-15) gained 192,147–240,626 life years (ranged over the variations of the nodule management protocol) and 20,335–25,467 averted deaths due to lung cancer and induced 3780–5069 million euro costs additional to no screening. The scenarios with the increased threshold of exposure to smoking (40 pack-years and maximum 10 years since quitting) limited the screened population and yielded around 31% less LYG (133,222–164,864) and 29% less averted deaths (14,373–17,889) and induced 37% fewer costs (2231–3178 million euro). Increasing the stopping age to 80 (55-80-30-15) yielded around 8.3% additional LYGs (207,468–260,807) and 14.4% more averted lung cancer deaths (23,029–29,165) compared to the 55-74-30-15 scenarios and a slightly increased reduction in lung cancer mortality (12.4%); however, it induced around 13.5% more costs (4159–5811 million euro) and the highest rate of overdiagnosis. Scenarios with the least restrictive eligibility criteria, 50-75-15-9, resulted in 50.5% more LYGs (295,093–362,039) and 45.6% more averted lung cancer deaths (30,147–37,075) vs the 55-74-30-15 scenarios; however, they led to 57% more healthcare costs (6447–8026 million euro additional to no screening) and a higher number of CT scans.
Generally, the scenarios with the NELSON-like nodule management protocol resulted in 1.1–1.3% fewer lung cancer findings, but around 2.3% more findings of cancer at an early stage, 3.3–3.4% more cases of averted lung cancer deaths, around 3% more LYGs, 0.1–0.9% fewer overdiagnosed cases and around 3% more interval cancers than the NLST-like strategies. The NLST-like scenarios yielded around 51–57.4% more follow-ups of malignant nodules and considerable additional costs.
Overall, across the evaluated 76 scenarios, a few tendencies in the effects of the nodule management protocols could be seen: (1) increasing the threshold for nodule size for a cancer-positive diagnosis slightly decreased overdiagnosis, LYG and averted lung cancer deaths; (2) decreasing the cut-off size yielded more overdiagnosed cases but did not improve numbers of LYG and averted lung cancer deaths; (3) altering threshold values for a cancer indicating nodule growth when the cut-off volume stayed the same did not appreciably change the rates of LYG and averted lung cancer deaths; (4) application of VDT or an increase in diameter as a single malignancy predictor in the two-step framework remarkably reduced the accuracy of lung cancer diagnosis, but it also notably decreased rates of overdiagnosis. Increasing the threshold nodule size for a follow-up in the NELSON-like scenarios from a volume of 50 mm3 to 80 mm3 and in the NLST-like scenarios from a diameter of 4 mm to 5 mm, as recommended by the British Thoracic Society , led to a 5% and 4% decrease in overdiagnosis and a 3.7–5% decline in LYG and averted lung cancer deaths.
Cost-effectiveness of screening
ACER ranged from 16,754 to 24,160 euro/LYG (Fig. 5) and from 155,287 to 230,678 euro/averted lung cancer death (Fig. 6). Out of the 76 evaluated scenarios, three scenarios were judged to be efficient based on their cost/LYG ratio and five scenarios based on their cost per averted lung cancer death ratio (Table 2).
The scenarios that featured NELSON and NLST clinical trials were less efficient (Figs. 4 and 5, NLST- and NELSON-resembling scenarios). Compared to the NELSON-like scenarios, NLST-based screening over 5 years of annual screening would result in considerably more total costs (around 450 million euro) while yielding around 800 fewer averted deaths. Considering the cost per life year gained ratio, characteristics of the not-dominated scenario included the most restrictive eligibility criteria (55-74-40-10) and the NELSON-like nodule management protocol which applies the assessment of VDT 3 months after the initial screening as a sole malignancy predictor (Scenario 65, Table 2). The scenario yielded an ICER of 16,754 euro/LYG. The second efficient scenario (Scenario 60, Table 2) combined the threshold VDT of 400 days and a cut-off nodule volume of 300 mm3. This scenario gained 31,642 additional life years for an incremental cost of 19,707 euro/LYG. The third efficient scenario (Scenario 41, Table 2) applied the same nodule management protocol and less stringent eligibility criteria (50-75-15-9). It gained an additional 197,174 life years for an incremental cost of 23,837 euro/LYG.
Two of the five scenarios, which were judged to be efficient based on averted cancer deaths, included the most restrictive selection criteria (55-75-40-10) and assessment of VDT 3 months later than the initial screening as a sole malignancy predictor for individuals with initial findings over 50 mm3 in volume (Scenarios 64 and 65, Table 2). The scenario with the lowest ICER of 155,287 euro per averted death (Scenario 65 with threshold VTD of 300 days) yielded 14,373 averted deaths. Increasing the threshold value of VDT to 400 days gained an additional 1000 averted deaths for an incremental cost of 161,124 euro (Scenario 64). The inclusion of the cut-off volume of 300 mm3 (Scenario 60) into the nodule management algorithm yielded 2500 more averted deaths for an incremental cost of 184,009 euro. The scenario with less restrictive selection criteria of exposure to smoking and the increased stopping age (55-80-30-15, Scenario 22) yielded 11,276 more averted lung cancer deaths for an ICER of 216,454 vs the previous efficient scenario. The scenario with the largest number of LYG (Scenario 41) is also the scenario with the largest yield of averted cancer deaths (37,075) for an ICER of 285,630 euro per averted death.
Figure 7 illustrates the discounted life years and additional costs (vs no screening) for the three efficient scenarios (Scenarios 65, 60 and 41) and for their variations in the sensitivity analyses. The main cost-effectiveness drivers are cost per CT exam, treatment costs and lung cancer long-term survival probability in screening. Relative to the baseline long-term survival probability (40%), its reduction to 20% led to a more than 50% reduction in LYG and averted deaths with a more than 100% increase in cost/LYG. Increase in cost per CT exam would have a stronger adverse effect on the cost-effectiveness if the less restrictive eligibility criteria were used. More expensive treatment with innovative targeted medication at a lifetime cost of 77,702 euro  would increase the ACER by 65%. An increase of the CT sensitivity for smaller nodules would slightly improve the cost-effectiveness; a 20% decrease of the sensitivity would lead to a more than 10% increase in ACER. Compared with perfect adherence (100%), decreasing adherence to 85% for the years following the initial screening led to a modest decline of ACER (around 1%). Screening strategy 60 (55-75-40-10-NELSON-VDT400-V300) becomes inefficient in the scenarios of the decreased adherence, decreased cost per CT exam and increased treatment cost (i.e. innovative treatment scenario). Due to high rates of detection and overdiagnosis, factors that increase ratio of treatment relative to the costs of screening have adverse effects on ICER compared to the previous efficient scenario. Scenario 65 (55-75-40-10-NELSON-VDT300-only) in turn becomes inefficient under conditions of increased screening costs. Expanding the period of the screening to 10 years did not considerably influence the cost-effectiveness. Detailed results of baseline and sensitivity analyses are available in Additional file 1: Sections 2.2–2.4.
The microsimulation analysis shows that lung cancer screening of the high-risk population in Germany can be cost-effective. A program with less restrictive eligibility criteria would be more effective but would induce a higher ICER due to screening of people with a lower risk of lung cancer development. The selection of heavier smokers and limitation of the screened population yields the lowest cost-effectiveness ratio compared with the no screening scenario. Increasing the stopping age, i.e. following the recommendations of the USPSTF , prevents additional deaths from lung cancer but also leads to considerable additional costs and increased overdiagnosis. Overall, if decision-making is based on the results of estimation of efficiency of an intervention, the scenarios that constitute an efficient frontier should be considered for implementation because other scenarios are proven to be less efficient. The efficiency frontier itself is shaped by the applied measure of efficiency.
Our study provides two efficiency frontiers based on weighting two major benefits of screening (LYG and averted lung cancer deaths) against the resulting costs (additional costs relative to the no screening scenario). The comparative modelling study by de Koning et al. for the USPSTF  in turn used “screenings per lung cancer death averted” as a measure of the efficiency. Based on this measure, the authors concluded that the eligibility criteria 55-80-30-15 are more efficient than the original NLST criteria. Considering their results for the screenings per LYG as the efficiency measure, the 55-80-30-15 scenario is still more effective but less efficient than the 55-75-30-15 scenario. Although we applied the additional cost in the numerator of the cost-effectiveness ratio, our findings are consistent with those by de Koning et al.: the selection criteria 55-80-30-15 are more efficient than 55-74-30-15 if the efficiency is estimated using the cost per averted lung cancer death ratio but less efficient based on the cost per life year gained ratio. Overall, both efficient frontiers outlined in our study do not include scenarios with the 55-74-30-15 population selection criteria.
Additionally, the efficiency measure “screenings per lung cancer death averted” used by the USPSTF to give the recommendation for screening does not include the harms of overdiagnosis. In our study, the cost side of the cost-effectiveness ratio includes the costs (related to screening and treatment) of the overdiagnosed cases and by that the overdiagnosis is incorporated into the measure of efficiency. In screening for lung cancer, overdiagnosis is thought to be “the most extreme form of length-time bias” . These cases include patients with tumours that would never have caused symptoms or been diagnosed in clinical settings. Stopping screening at age 80 leads to substantially higher numbers of overdiagnosed cases. This also has been shown in the studies by ten Haaf et al.  and de Koning et al. . In our analysis, the costs of the overdiagnosed cases account for about 30% of the difference in costs between the 55-80-30-15 and 55-74-30-15 scenarios. If the impact of overdiagnosis on the quality of life was included into estimation of the efficiency, it would be expected to further reduce the effectiveness and efficiency of the screening of an older population.
Ideally, all benefits and harms which are considered to be relevant for the identification of an optimal screening strategy should be included into the measure of effectiveness and efficiency. However, this would require a defined efficiency threshold  or prioritisation and weighting of the benefits and harms made by decision-makers. The aim of our study was to evaluate strategies for an introduction of a large-scale lung screening in Germany and to outline and discuss efficient scenarios rather than provide a solid recommendation.
Patient management strategy has a strong influence on long-term performance and cost-effectiveness of lung screening. The NELSON- and NLST-like nodule management protocols are comparably effective in reducing lung cancer mortality; however, the NELSON-like strategy is more successful in detection of early-stage lung cancers, yields fewer follow-up exams, and saves costs, and therefore may be preferable in clinical practice. The efficient screening scenarios highlight the combinations of the eligibility criteria and NELSON-like nodule management protocols, which may yield additional benefits without increasing the ICER. The cut-off volume for immediate diagnostic evaluation is a key element of the nodule management strategy. In the NELSON trial, the cut-off volume was defined as 500 mm3 and higher. Our results show that a decrease to 300 mm3 would be a more cost-effective strategy and may be justified for clinical practice. From the health economics perspective, our findings support previous inferences made by Horeweg and colleagues, who assessed probabilities of cancer development based on the NELSON data and concluded that patients with a screen-detected nodule of volume of 300 mm3 or more should undergo immediate diagnostic work-up . Additionally, variations of the nodule management elements show that the assessment of VDT at follow-up becomes more important if the threshold nodule volume is less restrictive (more than 500 mm3).
It is important to note that a decreased cut-off volume may lead to an increased number of overdiagnosed cases. In our analysis, the majority of the overdiagnosed cases were patients with slowly growing adenocarcinomas and AIS. Due to their slow growth, these are rarely symptomatically diagnosed  but may be detected by screening. Our results also suggest that scenarios which exclude the threshold nodule volume as the indicator for immediate diagnostic evaluation and apply the assessment of VDT (at the follow-up exam 3 months later) as a sole malignancy predictor can considerably reduce overdiagnosis; however, this can come at a high price of missing LYG and averted lung cancer deaths. Although a number of cases and the costs of overdiagnosis can be calculated in model settings, their effects on the health outcomes and quality of life need to be further investigated and quantified.
In this study, the effect of screening on quality of life could not be included in the analysis due to lack of German data on values of quality-adjusted life years (QALYs) across the lung cancer stages, sexes and age groups. The cost-effectiveness ratios in terms of costs per QALY gained would be expected to be notably higher than the estimated cost/LYG ratios . As long as the screening shifts the major part of diagnoses towards the early-stage cancers, more patients are likely to receive a resection operation. These patients are reported to have a considerably impaired quality of life during the first 2 years after lung resection but it may improve later [33, 34]. Additionally, with the application of QALYs, the negative effects of overdiagnosis and false positives would considerably increase [35, 36].
Several limitations are worth noting. Tumour growth is simulated using a Gompertzian growth model which does not capture abrupt changes in the development (growth) of the tumour. However, other studies have shown that cancer tumour growth can be well approximated by a Gompertz function . Our approach to modelling of false positives is rather simplified and does not allow for a comprehensive analysis of the false-positive outcomes at screening. The question of how to decrease the number of false-positive cases remains unanswered and requires additional information, which clinical trials may provide in the future. The limitations form a direction for further research into lung screening in Germany. There is a need to collect detailed data on tumours at time of diagnosis about their size, stage, smoking habits of the patients, treatment costs and quality of life of German patients with lung cancer, along with factors affecting screening uptake among the target groups. The cost-effectiveness of a combination of a smoking cessation intervention with a screening program is worth investigating.
Despite the limitations, the present study contributes insights on the impacts of the nodule management protocol on the effectiveness and cost-effectiveness of the introduction of a large-scale lung screening program. Additionally, this work is the first modelling study of microsimulation design which examines cost-effectiveness of the introduction of a large-scale lung screening program in a European country. The presented findings are comparable to the results reported in NLST  and previous modelling studies [2, 14, 18]. Because the developed model contains very little input obtained from the NLST data, comparison with the outcomes of NLST may serve as validation of the model. Outcomes of the model for the scenario most similar to NLST (Additional file 1: Section 2.2, Table S10) show a resembling distribution of histologic classes and stages of lung cancers detected at screening and interval cancers . NLST reports lung cancer mortality outcomes relative to radiography for a median follow-up of 6.5 years . We could compare these with the outcomes of our microsimulation model for 7 years of follow-up (Additional file 1: Table S14). In our analysis lung cancer mortality is considerably higher in the no screening settings and in the NLST-resembling scenario than reported in the trial; however, the differences between mortality rates in the screening and no screening scenarios are close to the differences in mortality rates between LDCT screening and radiography observed in NLST. Considering lung cancer mortality reduction as a ratio, due to the higher mortality rates the model reports a lower percentage (around 16%) in comparison to NLST (21%) . However, it still falls into the range given by confidence interval calculations in NLST. Our model also predicts a higher all-cause mortality rate than observed in NLST. The higher mortality may be caused by an older population and a larger proportion of current smokers in the screened cohorts; additionally, the settings of a clinical study and a possible “healthy-volunteer” effect  may positively affect the mortality outcomes of the clinical trial.
Overall, reduction in lung cancer mortality calculated over a lifetime course ranges from 9.7 to 12.8% and stays similar to the values reported in previous studies [2, 18]. Furthermore, the difference in the mortality rates between the no screening and screening arms is the basis for the economic evaluation, and it is very similar to that of the NLST trial. We therefore suggest that application of survival data other than that reported in NLST has a limited influence on the presented findings.
The cost-effectiveness has been analysed in modelling studies in the USA  and Canada . Due to the application of QALYs in the study by McMahon et al. (USA), the obtained cost-effectiveness ratios cannot be compared. Comparing the findings to the study by the Canadian team, the cost-effectiveness ratios obtained in this study lie within the range given by ten Haaf et al., despite differences in the applied cost inputs .
Overall, applicability of the presented results for other countries depends on the similarity of the cost structure and heavy smoker prevalence between the countries. The sensitivity analyses show that cost-effectiveness ratio is driven by cost per CT exam and other screening-related costs. The cost per CT exam taken in our study is not Germany-specific and is varied in the sensitivity analyses, giving an opportunity to transfer the results to other countries. The costs of lung cancer treatment tend to be higher in Germany, as in other European countries . Pharmaceutical companies continue to keep prices higher in Germany based on the expectation that German prices will become reference prices for the pharmaceuticals in other European countries . Lower costs of screening and lung cancer treatment in other countries may decrease the cost-effectiveness ratio and make population-based lung screening more cost-effective.
Due to differences in exposure to smoking in populations, cost structures and approaches to lung cancer treatment, efficient scenarios of lung screening can vary between the European countries. However, the main findings on the impacts of the nodule management protocol and population selection criteria on the cost-effectiveness of the screening can be applied to other countries.
This study quantifies the effect of nodule management approaches on the benefits, harms and cost-effectiveness of lung screening. Our analysis shows that the nodule management protocol has a considerable effect on screening performance and should be considered in greater detail when defining optimal screening strategies. It is the first cost-effectiveness analysis of lung cancer screening using a microsimulation design performed in a population-based setting in Germany. These results can support decision-making processes in lung cancer prevention and direct creation of guidelines for LDCT lung cancer screening to benefit the German population.
Average cost-effectiveness ratio
Adenocarcinoma in situ
Incremental cost-effectiveness ratio
Low-dose computed tomography
Life years gained
Netherlands-Leuvens Screening Trial
National Lung Screening Trial
Quality-adjusted life year
US Preventive Services Task Force
Volume doubling time
The National Lung Screening Trial Research Team. Results of initial low-dose computed tomographic screening for lung cancer. N Engl J Med. 2013;368:1980–91. doi:10.1056/NEJMoa1209120.
de Koning HJ, Meza R, Plevritis SK, ten Haaf K, Munshi VN, Jeon J, et al. Benefits and harms of computed tomography lung cancer screening strategies: a comparative modeling study for the U.S. Preventive Services Task Force. Ann Intern Med. 2014;160:311–20. doi:10.7326/M13-2316.
Detterbeck FC, Mazzone PJ, Naidich DP, Bach PB. Screening for lung cancer. Chest. 2013;143:e78S–92. doi:10.1378/chest.12-2350.
Humphrey LL. Screening for lung cancer with low-dose computed tomography: a systematic review to update the U.S. Preventive Services Task Force recommendation. Ann Intern Med. 2013;159:411. doi:10.7326/0003-4819-159-6-201309170-00690.
Moyer VA, on behalf of the U.S. Preventive Services Task Force. Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2014;160:330–8.
Horeweg N, Scholten ET, de Jong PA, van der Aalst CM, Weenink C, Lammers J-WJ, et al. Detection of lung cancer through low-dose CT screening (NELSON): a prespecified analysis of screening test performance and interval cancers. Lancet Oncol. 2014;15:1342–50. doi:10.1016/S1470-2045(14)70387-0.
van der Aalst CM, ten Haaf K, de Koning HJ. Lung cancer screening: latest developments and unanswered questions. Lancet Respir Med. 2016;4:749–61. doi:10.1016/S2213-2600(16)30200-4.
Pastorino U. Lung cancer screening. Br J Cancer. 2010;102:1681–6. doi:10.1038/sj.bjc.6605660.
Kauczor H-U, Bonomo L, Gaga M, Nackaerts K, Peled N, Prokop M, et al. ESR/ERS white paper on lung cancer screening. Eur Radiol. 2015;25:2519–31. doi:10.1007/s00330-015-3697-0.
Tammemagi MC, Katki HA, Hocking WG, Church TR, Caporaso N, Kvale PA, et al. Selection criteria for lung-cancer screening. N Engl J Med. 2013;368:728–36. doi:10.1056/NEJMoa1211776.
Mahadevia PJ, Fleisher LA, Frick KD, Eng J, Goodman SN, Powe NR. Lung cancer screening with helical computed tomography in older adult smokers. JAMA. 2003;289:313. doi:10.1001/jama.289.3.313.
Manser R, Dalton A, Carter R, Byrnes G, Elwood M, Campbell DA. Cost-effectiveness analysis of screening for lung cancer with low dose spiral CT (computed tomography) in the Australian setting. Lung Cancer. 2005;48:171–85. doi:10.1016/j.lungcan.2004.11.001.
Marshall D, Simpson KN, Earle CC, Chu C. Potential cost-effectiveness of one-time screening for lung cancer (LC) in a high risk cohort. Lung Cancer. 2001;32:227–36.
McMahon PM, Kong CY, Bouzan C, Weinstein MC, Cipriano LE, Tramontano AC, et al. Cost-effectiveness of computed tomography screening for lung cancer in the United States. J Thorac Oncol. 2011;6:1841–8. doi:10.1097/JTO.0b013e31822e59b3.
Pyenson BS, Sander MS, Jiang Y, Kahn H, Mulshine JL. An actuarial analysis shows that offering lung cancer screening as an insurance benefit would save lives at relatively low cost. Health Aff. 2012;31:770–9. doi:10.1377/hlthaff.2011.0814.
Shmueli A, Fraifeld S, Peretz T, Gutfeld O, Gips M, Sosna J, Shaham D. Cost-effectiveness of baseline low-dose computed tomography screening for lung cancer: the Israeli experience. Value Health. 2013;16:922–31. doi:10.1016/j.jval.2013.05.007.
Wisnivesky JP, Mushlin AI, Sicherman N, Henschke C. The cost-effectiveness of low-dose CT screening for lung cancer: preliminary results of baseline screening. Chest. 2003;124:614–21. doi:10.1378/chest.124.2.614.
ten Haaf K, Tammemägi MC, Bondy SJ, van der Aalst CM, Gu S, McGregor SE, et al. Performance and cost-effectiveness of computed tomography lung cancer screening scenarios in a population-based setting: a microsimulation modeling analysis in Ontario, Canada. PLoS Med. 2017;14, e1002225. doi:10.1371/journal.pmed.1002225.
Ruano-Ravina A, Pérez-Ríos M. Lung cancer screening with low-dose CT: more questions than answers. Lancet Oncol. 2015;16:e3–4. doi:10.1016/S1470-2045(14)71157-X.
Horeweg N, van Rosmalen J, Heuvelmans MA, van der Aalst CM, Vliegenthart R, Scholten ET, et al. Lung cancer probability in patients with CT-detected pulmonary nodules: a prespecified analysis of data from the NELSON trial of low-dose CT screening. Lancet Oncol. 2014;15:1332–41. doi:10.1016/S1470-2045(14)70389-4.
Lange C, Jentsch F, Allen J, Hoebel J, Kratz AL, von der Lippe E, et al. Data resource profile: German Health Update (GEDA)—the health interview survey for adults in Germany. Int J Epidemiol. 2015;44:442–50. doi:10.1093/ije/dyv067.
Statistisches Bundesamt. Bevölkerung und Erwerbstätigkeit: Ausgangsdaten der Bevölkerungsfortschreibung aus dem Zensus 2011. Wiesbaden: Federal Statistical Office; 2015.
Moolgavkar SH, Luebeck G. Two-event model for carcinogenesis: biological, mathematical, and statistical considerations. Risk Anal. 1990;10:323–41. doi:10.1111/j.1539-6924.1990.tb01053.x.
McMahon PM, Kong CY, Johnson BE, Weinstein MC, Weeks JC, Tramontano AC, et al. Chapter 9: the MGH-HMS lung cancer policy model: tobacco control versus screening. Risk Anal. 2012;32:S117–24. doi:10.1111/j.1539-6924.2011.01652.x.
Erasmus University Medical Center. MISCAN-Lung (Erasmus) MIcrosimulation SCreening Analysis (MISCAN) lung model. CISNET_ModelProfile_LUNG_ERASMUS_001_01132012_83607.pdf. Accessed 28 Jul 2016.
Horeweg N, van der Aalst CM, Vliegenthart R, Zhao Y, Xie X, Scholten ET, et al. Volumetric computed tomography screening for lung cancer: three rounds of the NELSON trial. Eur Respir J. 2013;42:1659–67. doi:10.1183/09031936.00197712.
Department of Health. The likely impact of earlier diagnosis of cancer on costs and benefits to the NHS. London: Department of Health; 2011. https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/213788/dh_123576.pdf. Accessed 17 Aug 2016.
Schremser K, Rogowski WH, Adler-Reichel S, Tufman ALH, Huber RM, Stollenwerk B. Cost-effectiveness of an individualized first-line treatment strategy offering erlotinib based on EGFR mutation testing in advanced lung adenocarcinoma patients in Germany. Pharmacoeconomics. 2015;33:1215–28. doi:10.1007/s40273-015-0305-8.
Callister MEJ, Baldwin DR, Akram AR, Barnard S, Cane P, Draffan J, et al. British Thoracic Society guidelines for the investigation and management of pulmonary nodules. Thorax. 2015;70 Suppl 2:ii1–54. doi:10.1136/thoraxjnl-2015-207168.
Postmus PE. Screening for lung cancer, an ongoing debate. Ann Oncol. 2008;19 Suppl 7:vii25–7. doi:10.1093/annonc/mdn464.
McCabe C, Claxton K, Culyer AJ. The NICE cost-effectiveness threshold: what it is and what that means. Pharmacoeconomics. 2008;26:733–44.
Read WL, Page NC, Tierney RM, Piccirillo JF, Govindan R. The epidemiology of bronchioloalveolar carcinoma over the past two decades: analysis of the SEER database. Lung Cancer. 2004;45:137–42. doi:10.1016/j.lungcan.2004.01.019.
Schulte T, Schniewind B, Dohrmann P, Kuchler T, Kurdow R. The extent of lung parenchyma resection significantly impacts long-term quality of life in patients with non-small cell lung cancer. Chest. 2009;135:322–9. doi:10.1378/chest.08-1114.
Schulte T, Schniewind B, Walter J, Dohrmann P, Kuchler T, Kurdow R. Age-related impairment of quality of life after lung resection for non-small cell lung cancer. Lung Cancer. 2010;68:115–20. doi:10.1016/j.lungcan.2009.05.019.
Wiener RS, Gould MK, Woloshin S, Schwartz LM, Clark JA. What do you mean, a spot? A qualitative analysis of patients' reactions to discussions with their physicians about pulmonary nodules. Chest. 2013;143:672–7. doi:10.1378/chest.12-1095.
van den Bergh KAM, Essink-Bot ML, Borsboom GJJM, Scholten ET, van Klaveren RJ, de Koning HJ. Long-term effects of lung cancer computed tomography screening on health-related quality of life: the NELSON trial. Eur Respir J. 2011;38:154–61. doi:10.1183/09031936.00123410.
Detterbeck FC, Gibson CJ. Turning gray: the natural history of lung cancer over time. J Thorac Oncol. 2008;3:781–92. doi:10.1097/JTO.0b013e31817c9230.
Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, Fagerstrom RM, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011;365:395–409. doi:10.1056/NEJMoa1102873.
McGuire A, Martin M, Lenz C, Sollano JA. Treatment cost of non-small cell lung cancer in three European countries: comparisons across France, Germany, and England using administrative databases. J Med Econ. 2015;18:525–32. doi:10.3111/13696998.2015.1032974.
Leopold C, Mantel-Teeuwisse AK, Seyfang L, Vogler S, de Joncheere K, Laing RO, Leufkens H. Impact of external price referencing on medicine prices — a price comparison among 14 European countries. Southern Med Review. 2012;5:34–41.
This work was supported by the German Federal Ministry of Education and Research (01EH1201A).
Availability of data and materials
The data used in the present analyses can be found in the studies cited in the text. The resulting data is also presented in Additional file 1. All other datasets generated during the simulations are available from the corresponding author upon reasonable request.
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Outside the submitted work during conduction of the study, T Welte has received grants from the Ministry of Research and Education and personal fees from AstraZeneca, GlaxoSmithKline, Bayer, Novartis, Pfizer, Boehringer and Merck Sharp & Dohme. M Treskova, I Aumann, H Golpon, J Vogel-Claussen and A Kuhlmann have declared no conflicts of interest.
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Treskova, M., Aumann, I., Golpon, H. et al. Trade-off between benefits, harms and economic efficiency of low-dose CT lung cancer screening: a microsimulation analysis of nodule management strategies in a population-based setting. BMC Med 15, 162 (2017). https://doi.org/10.1186/s12916-017-0924-3
- LDCT lung screening
- Lung cancer
- Nodule management protocol