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Fig. 4 | BMC Medicine

Fig. 4

From: A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis

Fig. 4

Characterization of HBV integration sites in Mount Sinai dataset. a The number of unique fusion transcripts and recurrent fusion transcripts was compared between non-neoplastic liver and tumor tissues. P value was measured from Wilcoxon rank sum test. b, c The distribution of HBV integration sites (407 in non-neoplastic liver and 118 in tumor tissues) in viral genome (b) and human transcripts (c). d Genome-wide distribution of HBV host genes (374 in normal and 106 in tumor) across entire chromosomes. Names of host genes are shown if they were observed from more than two samples. Labels in blue indicate when the host gene was identified both in normal and tumor. e Host transcripts with HBV integration in the Mount Sinai dataset are compared with results from other datasets. For BGI, TCGA, and ICGA datasets, HBV integration sites were identified from our pipeline. The significance of overlap was tested based on Fisher’s exact test

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