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Preparing for a pandemic: highlighting themes for research funding and practice—perspectives from the Global Research Collaboration for Infectious Disease Preparedness (GloPID-R)

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Funders and researchers around the world are responding to the COVID-19 pandemic at urgent speed, with greater effectiveness and collaboration than ever before. In the past 8 months, the global health research community has collectively generated and shared a huge amount of knowledge in particular into the clinical characterisation, behavioural insights, genetics, epidemiology, viral pathogenesis, clinical management and diagnosis of COVID-19. This is built on substantial prior preparation, with researchers, public health professionals, funders and multilateral bodies in this field having anticipated and prepared for a pandemic for many years. Further knowledge is needed however to control this pandemic and for safe easing of public health measures.

The Global Research Collaboration for Infectious Disease Preparedness (GloPID-R) is an international network of global health funders and stakeholders formed in 2013 to ensure preparedness for a coordinated research response to epidemics and pandemics [1]. GloPID-R aims to address challenges to effective research in epidemics and pandemics, through both preparedness and response activities.

In December 2019, as part of its preparedness activities, GloPID-R convened a Frontiers meeting with their funded clinical trial networks and cohorts along with key stakeholders involved in emerging epidemic and pandemic preparedness and response globally. The aim was to identify how these groups might collaborate in delivering a coordinated research response in the event of an epidemic or pandemic. Now that we are in the midst of the COVID-19 pandemic, it is important to highlight and reflect on the recommendations identified by these participants, to inform the ongoing research funding and practice during the COVID-19 pandemic as well as preparedness for future outbreaks.

Preparedness themes for research funding and practice

Research cohorts are valuable tools for building pandemic research responses

Active cohort studies have the potential to play a key role in emerging epidemic and pandemic research. Longitudinal cohorts generate a wealth of data from individual participants about clinical and laboratory outcomes, which allow for a better understanding of effect modifiers such as genetic factors, chronic disease, socio-demographic factors and long-term outcomes than is possible from other study designs. Established cohorts can also function as a broker between emerging disease researchers and the community addressing challenges to the acceptance of research [2].

There was a call for newly funded cohorts to be designed to be both usable and re-usable in the event of new emerging research questions.

Research capacity and activity mapping are essential to facilitate collaboration and improve targeting of resources

Improved mapping of both global research capacity and ongoing global research activities was identified as necessary to improve identification of opportunities for collaboration and ‘pivoting’ or ‘supplementing’ of ongoing research efforts in outbreaks and improve coordination as pandemics shift globally.

Research collaboration especially between clinical trial networks and cohorts is essential to improve research outcomes

Coordination, in particular across clinical trials and cohorts, is needed to make the most effective use of scarce resources to ensure that studies are not underpowered due to changes in infection rates in differing geographical areas.

Sustainability of funding and research capacity during inter-epidemic periods is key to ensure quality research can be initiated rapidly for epidemics and pandemics

Setting up completely new studies during epidemics and pandemics takes substantial time from the funding commitment, developing necessary infrastructure, research processes and approvals and most importantly trust within the community and leads to fragmentation. Therefore, it may be more efficient to build on large existing studies with baseline continuous research activities, which allow the recruitment of patients from the outset of an outbreak.

Strengthening local research capacity and working closely with governments, local and regional partners and communities to develop and lead national research plans are necessary to ensure critical activities.

Rapid research and funding systems and rapid data sharing are needed to facilitate knowledge generation to improve practice within epidemics and pandemics

Rapid mobilisation of research funds and resources, early engagement with ethics committees and staged approved ethical protocols, adaptive studies and trial designs were all identified as necessary steps to reduce the significant prior delays in initiating research activities in the epidemic response. Funders acknowledged that for many, current funding structures are often not flexible enough to allow quick pivoting or redirection of resources.

Rapid data sharing is needed to accelerate health benefits and outcomes, to facilitate timely dissemination of data to the public for action, and to prevent misinformation. The GloPID-R Data Sharing Roadmap [3] highlights the key steps to address to enable global data sharing, and the meeting highlighted the need to share emerging barriers and potential solutions in its implementation.

Ethics and social science need to be core to broader epidemic pandemic and research response activities

Ethics should be at the heart of decision-making and an opportunity for researchers to ensure that the optimal value is being obtained from the research for all stakeholders involved, including communities and individuals. Solutions to improve acceptance and uptake of research by healthcare workers and participants are also crucial along with the need for greater inclusion and translation to the practice of qualitative and social sciences studies in epidemics.


These six preparedness recommendations have already been mirrored and in many cases directly informed practice during the COVID-19 research response (see Table 1).

Table 1 COVID-19 relevant practice and ongoing priorities linked to the GloPID-R Frontiers meeting recommendations

There is potential for further leveraging and global coordination of both existing cohorts and clinical trial networks to improve research quality and outcomes during epidemics and pandemics.

Timely, effective epidemic research to improve health outcomes can only be achieved if multidisciplinary research structures, regulatory functions, funding, partnerships and trust are built and maintained sustainably during inter-epidemic periods. Building sustainable research capacity and capability globally needs to be central to research on the COVID-19 pandemic and for future epidemics and pandemics. Sustainable active studies and multidisciplinary networks, with pre-approved protocols positioned strategically globally, need to build upon this.


Lessons learned from the COVID-19 research response need to be incorporated into a multidisciplinary framework to facilitate rapid, coordinated research funding and support structures for researchers, to provide an even faster and coordinated research response, avoiding redundancy. New funder principles for research in epidemics provide the first step toward this [7].

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  1. Matthiessen L, et al. Coordinating funding in public health emergencies. Lancet. 2016;(2016).

  2. Sigfrid L, et al. Addressing political, economic, administrative, regulatory, logistical, ethical, and social challenges to clinical research responses to emerging epidemics and pandemics: a systematic review. Lancet. 2019;394(2).

  3. Norton A, Pardinaz-Solis R & Carson G. 2019. GloPID-R Roadmap for data sharing in public health emergencies. Available from:

  4. UKCDR and GloPID-R COVID-19 Research Project Tracker, 2020,

  5. Principles for data sharing in public health emergencies. GloPID-R data sharing working group. London: Figshare; 2017. Available from: doi: [cited 2020 Jul 07].

  6. A Coordinated Global Research Roadmap: 2019 Novel Coronavirus. Available at:

  7. Norton A, Mphahlele J, Yazdanpanah Y, Piot P, Bayona MT. Strengthening the global effort on COVID-19 research. The Lancet. 2020;396(10248):375.

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Meeting participants:

Adeniyi Aderoba (University of Oxford, Oxford, UK; University of Medical Sciences Teaching Hospital, Ondo State, Nigeria); John Amuasi (ALERRT, Kumasi, Ghana); Amrish Baidjoe (EAN, RECON, London, UK); Peter Bannister (Brighton & Sussex Medical School, Brighton, UK); Genevieve Boily-Larouche (CIHR, Ottawa, Canada); Elaine Boylan (MRC, London, UK); Serge Breysse (GloPID-R, Paris, France); David Carr (Wellcome Trust, London, UK); Gail Carson (GloPID-R, Oxford, UK); Amol Chaudhari (CEPI, London, UK); Guy Cochrane (EMBL-EBI, Hinxton, UK); Shelui Collinson (NHS, London, UK); Chioma Dan-Nwafor (Nigeria Centre for Disease Control (NCDC), Abuja, Nigeria); Xavier De Lamballerie (UVE, Marseille, France); Evelyn Depoortere (European Commission); Lennie Derde (REMAP-CAP, Utrecht, Netherlands); Eric Dortenzio (REACTing, Paris, France); Tamara Giles Vernick (Institut Pasteur, Paris, France); Nina Gobat (PREPARE, ECRAID, Oxford, UK); Josie Golding (Wellcome Trust, London, UK); Herman Goossens (PREPARE, ECRAID, Brussels, Belgium); Jean Marie Habarugira (EDCTP, Hague, Netherlands); Ana Maria Henao Restrepo (WHO, Geneva, Switzerland); David Heymann (LSHTM, London, UK); Elisabeth Higgs (NIH, HHS, USG, Bethesda, USA); Bruno Hoen (Institut Pasteur, Paris, France); William Hsiao (BCCDC PHL, Vancouver, Canada); Thomas Jaenisch (ReCoDID, Heidelberg, Germany); Nina Jamieson (ISARIC, Oxford, UK); Marie Jaspard (ALIMA, Paris, France); Barbara Kerstiëns (European Commission); Trudie Lang (TGHN, Oxford, UK); Joanne Langley (Dalhousie University, Halifax, Canada); James Lee (ISARIC, Oxford, UK); Katherine Littler (WHO, Geneva, Switzerland); Dermot Maher (TDR, Geneva, Switzerland); Denis Malvy (Bordeaux University Hospital, Bordeaux, France); Gustavo Matta (FIOCRUZ, Rio de Janeiro, Brazil); Romans Matulevics (ISARIC, Oxford, UK); Laura Merson (IDDO, Oxford, UK); Shoji Miyagawa (AMED, Tokyo, Japan); Naima Nasir (University of Oxford, Oxford, UK; APIN-Supported HIV Treatment Centre, Jos University Teaching Hospital, Jos, Nigeria); Robert Newton (ALPHA, LSHTM, Entebbe, Uganda); Alice Norton (GloPID-R, Oxford, UK); Piero Olliaro (ISARIC, Oxford, UK); Hitoshi Oshitani (Tohoko University Graduate School of Medicine, Sendai, Japan); Barbara Rath (PEDSIDEA, Vienna Vaccine Safety Initiative, Berlin, Germany); David Robertson (University of Edinburgh, Edinburgh, UK); Cathy Roth (DFID, London, UK); Kathy Rowan (REMAP-CAP, London, UK); Nahoko Shindo (WHO, Geneva, Switzerland); Louise Sigfrid (ERGO, Oxford, UK); Stefanie Sowinski (European Commission); David Vaughn (BMGF, Seattle, USA); Richard Wilder (CEPI, London, UK); Annelies Wilder Smith (LSHTM, London, UK); Jimmy Whitworth (LSHTM, London, UK); Katharine Wright (Nuffield Council on Bioethics, London, UK); Yazdan Yazdanpanah (GloPID-R, Paris, France); and Lay-Myint Yoshida (Nagasaki University, Nagasaki, Japan).


The GloPID-R Secretariat is funded through the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement 643434.

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Norton, A., Sigfrid, L., Aderoba, A. et al. Preparing for a pandemic: highlighting themes for research funding and practice—perspectives from the Global Research Collaboration for Infectious Disease Preparedness (GloPID-R). BMC Med 18, 273 (2020).

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