Fig. 2
From: P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss
Changes of fetal body/placental weights, fetal serum/placental corticosterone levels, and placental P-glycoprotein (P-gp) expression in prenatal caffeine exposure (PCE)-related intrauterine growth retardation (IUGR) rat model. A Fetal body weight; B placental weight; C fetal body weight/placental weight; D IUGR rate; E–G corticosterone levels in maternal serum, fetal serum, and placentas; H immunostaining of P-gp (400×), n=5; I, J relative mRNA expression levels of ATP-binding cassette, sub-family B, member 1a (abcb1a) and abcb1b, n=10–12; K protein level of placental P-gp, n=3; L, M correlations between abcb1a or abcb1b mRNA expression levels and fetal body weights; N, O correlations between abcb1a or abcb1b mRNA expression levels and placental weights; P correlations between fetal body weights and fetal serum corticosterone concentrations; Q correlation between placental weights and placental corticosterone levels. n=34. Mean ± S.E.M. *P<0.05, **P<0.01 vs. control