Fig. 5
From: Triggering anti-GBM immune response with EGFR-mediated photoimmunotherapy
Histological analysis of the treatment efficacy in U87-MGvIII orthotopic tumours 1, 4, and 24 h post-PIT. Representative haematoxylin/eosin staining and corresponding Ki67 and HSP70 immunostaining of the brain tumours (× 10 and × 20). Red arrows indicate haemorrhagic areas, black arrows indicate pyknosis and apoptotic bodies, and white arrows indicate necrotic areas. Control mice were irradiated with 100 J/cm2. Treated mice were injected i.v. with 18 μg of the ZEGFR:03115-IR700 conjugate and irradiated with 100 J/cm2