Exposure | Method | OR (95% C)) | p-value |
---|---|---|---|
Education (219 SNPs) | Weighted median | 0.34 (0.27, 0.43) | <0.001 |
MR-Egger | 0.39 (0.18, 0.85) | 0.018 | |
MR-PRESSO (3 outliers) | 0.30 (0.25, 0.36) | <0.001 | |
Contamination mixture | 0.23 (0.17, 0.32) | <0.001 | |
MR-Mode | 0.58 (0.27, 1.26) | 0.168 | |
MR-Mix | 0.37 (0.23, 0.59) | <0.001 | |
GSMR | 0.29 (0.25–0.34) | <0.001 | |
Household income (42 SNPs) | Weighted median | 0.49 (0.34, 0.72) | <0.001 |
MR-Egger | 1.64 (0.38, 7.00) | 0.508 | |
MR-PRESSO (1 outlier) | 0.38 (0.29, 0.51) | <0.001 | |
Contamination mixture | 0.37 (0.25, 0.54) | <0.001 | |
MR-Mode | 0.69 (0.34, 1.40) | 0.308 | |
MR-Mix | 0.37 (0.23, 0.60) | <0.001 | |
GSMR | 0.28 (0.21, 0.38) | <0.001 | |
Townsend deprivation index (17 SNPs) | Weighted median | 5.51 (2.22, 13.71) | <0.001 |
MR-Egger | 0.04 (0.00, 229.4) | 0.482 | |
MR-PRESSO (2 outliers) | 4.86 (2.11, 11.19) | 0.002 | |
Contamination mixture | 8.25 (3.78, 27.39) | 0.001 | |
MR-Mode | 8.94 (1.58, 50.69) | 0.025 | |
MR-Mix | 1.00 (1.00, 1.00) | 0.99 | |
GSMR | 4.92 (2.95, 8.21) | <0.001 | |
Intelligence (132 SNPs) | Weighted median | 0.59 (0.48, 0.73) | <0.001 |
MR-Egger | 0.68 (0.27, 1.72) | 0.416 | |
MR-PRESSO (4 outliers) | 0.58 (0.48, 0.69) | <0.001 | |
Contamination mixture | 0.53 (0.44, 0.62) | <0.001 | |
MR-Mode | 0.59 (0.37, 0.97) | 0.037 | |
MR-Mix | 0.50 (0.31–0.81) | 0.005 | |
GSMR | 0.53 (0.46–0.60) | <0.001 |