Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. The Lancet. 2012;380:37–43.
Article
Google Scholar
Mair FS, May CR. Thinking about the burden of treatment. BMJ : British Medical Journal. 2014;349: g6680.
Article
PubMed
Google Scholar
Whitty CJM, MacEwen C, Goddard A, et al. Rising to the challenge of multimorbidity. BMJ. 2020;368: l6964.
Article
PubMed
PubMed Central
Google Scholar
Multimorbidity: a priority for global health research. Academy of Medical Sciences 2018. https://acmedsci.ac.uk/file-download/82222577.
Coresh J. Update on the burden of CKD. Journal of the American Society of Nephrology. 2017;28:1020.
Article
PubMed
PubMed Central
Google Scholar
Stevens PE, Levin A, Members* for the KDIGOCKDGDWG. Evaluation and management of chronic kidney disease: synopsis of the Kidney Disease: Improving Global Outcomes 2012 clinical practice guideline Ann Intern Med 2013 158 825 30
Tonelli M, Wiebe N, Manns BJ, et al. Comparison of the complexity of patients seen by different medical subspecialists in a universal health care system. JAMA Netw Open. 2018;1:e184852–e184852.
Article
PubMed
PubMed Central
Google Scholar
Sullivan MK, Jani BD, McConnachie A, et al. Hospitalisation events in people with chronic kidney disease as a component of multimorbidity: parallel cohort studies in research and routine care settings. BMC Med. 2021;19:278.
Article
PubMed
PubMed Central
Google Scholar
van der Velde M, Matsushita K, Coresh J, et al. Lower estimated glomerular filtration rate and higher albuminuria are associated with all-cause and cardiovascular mortality. a collaborative meta-analysis of high-risk population cohorts. Kidney Int. 2011;79:1341–52.
Article
PubMed
Google Scholar
Research NI for H. NIHR Collection: Multiple long-term conditions (multimorbidity): making sense of the evidence. 2021 https://doi.org/10.3310/collection_45881.
Bretos-Azcona PE, Sánchez-Iriso E, Cabasés Hita JM. Tailoring integrated care services for high-risk patients with multiple chronic conditions: a risk stratification approach using cluster analysis. BMC Health Serv Res. 2020;20:806.
Article
PubMed
PubMed Central
Google Scholar
Carrero JJ, Elinder CG. The Stockholm CREAtinine Measurements (SCREAM) project: fostering improvements in chronic kidney disease care. J Intern Med 2022; n/a. https://doi.org/10.1111/joim.13418.
Lyons RA, Jones KH, John G, et al. The SAIL databank: linking multiple health and social care datasets. BMC Med Inform Decis Mak. 2009;9:3.
Article
PubMed
PubMed Central
Google Scholar
Levey AS, Coresh J, Greene T, et al. Expressing the modification of diet in renal disease study equation for estimating glomerular filtration rate with standardized serum creatinine values. Clin Chem. 2007;53:766–72.
Article
CAS
PubMed
Google Scholar
Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150:604–12.
Article
PubMed
PubMed Central
Google Scholar
Tonelli M, Wiebe N, Fortin M, et al. Correction to: Methods for identifying 30 chronic conditions: application to administrative data. BMC Med Inform Decis Mak. 2019;19:177.
Article
PubMed
PubMed Central
Google Scholar
Huang Z. A fast clustering algorithm to cluster very large categorical data sets in data mining. In: Lu H, Motoda H, Luu H, editors. KDD: techniques and applications. Singapore: World Scientific; 1997. p. 21–34.
Google Scholar
Kaufman L, Rousseeuw P. Finding groups in data: an introduction to cluster analysis. New York: Wiley; 1990.
Book
Google Scholar
Guisado-Clavero M, Roso-Llorach A, López-Jimenez T, et al. Multimorbidity patterns in the elderly: a prospective cohort study with cluster analysis. BMC Geriatr. 2018;18:16.
Article
PubMed
PubMed Central
Google Scholar
Sjölander A. Regression standardization with the R package stdReg. Eur J Epidemiol. 2016;31:563–74.
Article
PubMed
Google Scholar
R Core Team. R : a language and environment for statistical computing. 2021.
Zheng Z, Waikar SS, Schmidt IM, et al. Subtyping CKD patients by consensus clustering: the Chronic Renal Insufficiency Cohort (CRIC) study. Journal of the American Society of Nephrology. 2021;32:639.
Article
CAS
PubMed
PubMed Central
Google Scholar
Vetrano DL, Roso-Llorach A, Fernández S, et al. Twelve-year clinical trajectories of multimorbidity in a population of older adults. Nat Commun. 2020;11:3223.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lawson CA, Seidu S, Zaccardi F, et al. Outcome trends in people with heart failure, type 2 diabetes mellitus and chronic kidney disease in the UK over twenty years. EClinicalMedicine. 2021;32: 100739.
Article
PubMed
PubMed Central
Google Scholar
Dubrofsky L, Lee JF, Hajimirzarahimshirazi P, et al. A unique multi- and interdisciplinary cardiology-renal-endocrine clinic: a description and assessment of outcomes: 2022; 9. https://doi.org/10.1177/20543581221081207.
Zimbudzi E, Lo C, Robinson T, et al. The impact of an integrated diabetes and kidney service on patients, primary and specialist health professionals in Australia: a qualitative study. PLoS One. 2019;14(7):e0219685.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zimbudzi E, Lo C, Ranasinha S, et al. Health-related quality of life among patients with comorbid diabetes and kidney disease attending a codesigned integrated model of care: a longitudinal study. BMJ Open Diabetes Res Care. 2020;8:842.
Article
Google Scholar
Baigent C, Landray MJ, Reith C, et al. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial. The Lancet. 2011;377:2181–92.
Article
CAS
Google Scholar
Lewis EJ, Hunsicker LG, Clarke WR, et al. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. New England Journal of Medicine. 2001;345:851–60.
Article
CAS
PubMed
Google Scholar
Lewis EJ, Hunsicker LG, Bain RP, Rohde RD. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. New England Journal of Medicine. 1993;329:1456–62.
Article
CAS
PubMed
Google Scholar
Ruggenenti P, Perna A, Loriga G, et al. Blood-pressure control for renoprotection in patients with non-diabetic chronic renal disease (REIN-2): multicentre, randomised controlled trial. The Lancet. 2005;365:939–46.
Article
Google Scholar
Hou FF, Zhang X, Zhang GH, et al. Efficacy and safety of benazepril for advanced chronic renal insufficiency. New England Journal of Medicine. 2006;354:131–40.
Article
CAS
PubMed
Google Scholar
Heerspink HJL, Stefánsson B v, Correa-Rotter R, et al. Dapagliflozin in patients with chronic kidney disease. N Engl J Med. 2020;383(15):1436–46.
Article
CAS
PubMed
Google Scholar
Perkovic V, Jardine MJ, Neal B, et al. Canagliflozin and renal outcomes in type 2 diabetes and nephropathy. New England Journal of Medicine. 2019;380:2295–306.
Article
CAS
PubMed
Google Scholar
Stevens PE, Levin A. Evaluation and management of chronic kidney disease: synopsis of the Kidney Disease: Improving Global Outcomes 2012 clinical practice guideline. Ann Intern Med. 2013;158:825–30.
Article
PubMed
Google Scholar
Lambourg E, Colvin L, Guthrie G, et al. The prevalence of pain among patients with chronic kidney disease using systematic review and meta-analysis. Kidney Int. 2021;100:636–49.
Article
PubMed
Google Scholar
Zhu Y, Edwards D, Mant J, Payne RA, Kiddle S. Characteristics, service use and mortality of clusters of multimorbid patients in England: a population-based study. BMC Med. 2020;18:78.
Article
PubMed
PubMed Central
Google Scholar
Zhan M, Doerfler RM, Xie D, et al. Association of opioids and nonsteroidal anti-inflammatory drugs with outcomes in CKD: findings from the CRIC (Chronic Renal Insufficiency Cohort) study. American Journal of Kidney Diseases. 2020;76:184–93.
Article
CAS
PubMed
PubMed Central
Google Scholar
Corsonello A, Fabbietti P, Formiga F, et al. Chronic kidney disease in the context of multimorbidity patterns: the role of physical performance. BMC Geriatr. 2020;20:350.
Article
PubMed
PubMed Central
Google Scholar
Hirst JA, Ordóñez Mena JM, O’Callaghan CA, et al. Prevalence and factors associated with multimorbidity among primary care patients with decreased renal function. PLoS One. 2021;16:e0245131.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mercer SW, Gunn J, Bower P, Wyke S, Guthrie B. Managing patients with mental and physical multimorbidity. BMJ : British Medical Journal. 2012;345: e5559.
Article
PubMed
Google Scholar
Shirazian S, Grant CD, Aina O, Mattana J, Khorassani F, Ricardo AC. Depression in chronic kidney disease and end-stage renal disease: similarities and differences in diagnosis, epidemiology, and management. Kidney Int Rep. 2016;2:94–107.
Article
PubMed
PubMed Central
Google Scholar
Smith SM, Wallace E, O’Dowd T, Fortin M. Interventions for improving outcomes in patients with multimorbidity in primary care and community settings. Cochrane Database of Systematic Reviews 2021; 2021. https://doi.org/10.1002/14651858.CD006560.pub4.
Stokes J, Guthrie B, Mercer SW, Rice N, Sutton M. Multimorbidity combinations, costs of hospital care and potentially preventable emergency admissions in England: a cohort study. PLoS Med. 2021;18:e1003514.
Article
PubMed
PubMed Central
Google Scholar
British Lung Foundation. 2022.
Stevens RJ, Evans J, Oke J, et al. Kidney age, not kidney disease. Can Med Assoc J. 2018;190:E389.
Article
Google Scholar
Zemedikun DT, Gray LJ, Khunti K, Davies MJ, Dhalwani NN. Patterns of multimorbidity in middle-aged and older adults: an analysis of the UK biobank data. Mayo Clin Proc. 2018;93:857–66.
Article
PubMed
Google Scholar