Table 2 Adjusted hazard ratios (95% confidence intervals) of overall and type-specific early-onset kidney diseases later in life for children with diabetes
Type of kidney disease | DM | T1DM | T2DM | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. (%) of kidney disease in exposed/unexposed groups | Rate per 1000 person-years in exposed/unexposed groups | Crude HR (95% CI) | Adjusted HR (95% CI) | No. (%) of kidney disease in exposed/unexposed groups | Rate per 1000 person-years in exposed/unexposed groups | Crude HR (95% CI) | Adjusted HR (95% CI) | No. (%) of kidney disease in exposed/unexposed group | Rate per 1000 person-years in exposed/unexposed groups | Crude HR (95% CI) | Adjusted HR (95% CI) | |
Any kidney disease | 340(3.63)/1376(1.47) | 26.93/10.66 | 2.54 (2.25–2.86) | 2.54 (2.38–2.72) | 283(3.34)/1176(1.39) | 25.45/10.36 | 2.47 (2.17–2.81) | 2.48 (2.31–2.67) | 57(6.43)/200(2.26) | 37.87/12.88 | 2.96 (2.20–3.98) | 2.75 (2.28–3.31) |
Glomerular diseases | 57(0.61)/161(0.17) | 4.51/1.25 | 3.58 (2.64–4.84) | 3.56 (2.97–4.27) | 42(0.50)/135(0.16) | 3.77/1.19 | 3.12 (2.20–4.41) | 3.14 (2.57–3.83) | 15(1.69)/26(0.29) | 9.96/1.67 | 6.11 (3.21–11.65) | 5.84 (3.69–9.24) |
Renal tubulo-interstitial diseases | 166(1.77)/619(0.66) | 13.14/4.80 | 2.75 (2.32–3.27) | 2.74 (2.48–3.02) | 147(1.74)/538(0.64) | 13.21/4.74 | 2.81 (2.34–3.38) | 2.83 (2.55–3.14) | 19(2.14)/81(0.91) | 12.62/5.22 | 2.34 (1.42–3.86) | 2.00 (1.46–2.74) |
Renal failure | 100(1.07)/115(0.12) | 7.91/0.89 | 9.16 (6.97–12.03) | 9.13 (7.49–11.14) | 78(0.92)/98(0.12) | 7.01/0.86 | 8.23 (6.09–11.13) | 8.24 (6.66–10.20) | 22(2.48)/17(0.19) | 14.58/1.09 | 15.26 (7.81–29.83) | 14.77 (8.53–25.59) |
Urolithiasis | 65(0.69)/491(0.52) | 5.15/3.80 | 1.37 (1.06–1.78) | 1.39 (1.20–1.61) | 50(0.59)/409(0.48) | 4.49/3.60 | 1.26 (0.94–1.69) | 1.27 (1.07–1.50) | 15(1.69)/82(0.93) | 9.96/5.28 | 1.96 (1.12–3.40) | 1.94 (1.40–2.69) |
Injury of kidney | 8(0.09)/72(0.08) | 0.63/0.56 | 1.15 (0.55–2.38) | 1.14 (0.75–1.75) | 8(0.09)/65(0.08) | 0.72/0.57 | 1.28 (0.61–2.66) | 1.28 (0.85–1.95) | – | – | – | – |
Other disorders of kidney and ureter | 41(0.44)/89(0.10) | 3.25/0.69 | 4.71 (3.25–6.83) | 4.80 (3.80–6.05) | 32(0.38)/74(0.09) | 2.88/0.65 | 4.46 (2.94–6.78) | 4.57 (3.54–5.90) | 9(1.02)/15(0.17) | 5.98/0.97 | 5.87 (2.57–13.41) | 5.42 (2.99–9.81) |