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Childhood diabetes mellitus and early-onset kidney diseases later in life: a nationwide population-based matched cohort study

BMC Medicine volume 20, Article number: 428 (2022) Cite this article

A Correction to this article was published on 01 June 2023

This article has been updated

Abstract

Background

The empirical evidence remains inconclusive for an association between diabetes mellitus (DM) in children and early-onset kidney disease later in life, and little is known about the effects of DM types (i.e., type 1 diabetes [T1DM] and type 2 diabetes [T2DM]) in childhood on type-specific kidney diseases. We aimed to evaluate the association of childhood DM with overall and type-specific early-onset kidney diseases later in life.

Methods

The population-based matched cohort study included 9356 individuals with DM (T1DM: 8470, T2DM: 886) diagnosed in childhood (< 18 years) who were born between 1977 and 2016, and 93,560 individuals without DM matched on sex and year of birth in Denmark. The main outcomes were overall and type-specific early-onset kidney diseases. The follow-up period of all included participants was from the date of DM diagnosis in the exposure group until the first diagnosis of kidney disease, emigration, or 31 December 2018, whichever came first.

Results

During a median follow-up of 13 years, children with DM had a 154% increased risk of early-onset kidney diseases than children without DM (adjusted hazard ratios 2.54, 95% confidence intervals 2.38–2.72), and T1DM (2.48, 2.31–2.67) and T2DM (2.75, 2.28–3.31) showed similar results. Children with DM also had a higher risk of multiple specific kidney diseases including glomerular diseases, renal tubulo-interstitial diseases, renal failure, and urolithiasis. The risks of type-specific kidney diseases including glomerular diseases and renal failure tended to be higher for children with T2DM (glomerular diseases: 5.84, 3.69–9.24; renal failure: 14.77, 8.53–25.59) than those with T1DM (glomerular diseases: 3.14, 2.57–3.83; renal failure: 8.24, 6.66–10.20).

Conclusions

Children with DM had a higher increased risk of early-onset overall and specific kidney diseases later in life. Early prevention and treatment of both T1DM and T2DM in childhood may significantly reduce the risk of kidney diseases later in life.

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Background

Diabetes mellitus (DM) is one of the leading chronic medical disorders among children and adolescents [1]. The prevalence of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) during childhood has been increasing worldwide [2,3,4]. An annual increase of 3.4% in the prevalence of T1DM between 1989 and 2013 was reported among European children under 14 years [3]. In the USA, the prevalence of T2DM among those aged < 19 years increased from 1.48 per 1000 youths in 2001 to 2.15 in 2017 [5]. In Denmark, the prevalence of T1DM has been increasing in childhood from ~ 0.20 per 1000 person-years in 1996 to ~ 0.35 per 1000 person-years in 2016 [6]. Although the prevalence of T2DM among Danish youth in 2014 was 0.6 per 100,000 inhabitants, T2DM was highly associated with overweight and obesity which has a significant increase in Danish youth [7, 8]. DM in children and adolescents poses a major public health burden and clinical challenges to pediatric and adult DM services [1, 9].

Youth-onset T2DM may cause longer exposure to the adverse effects of hyperglycemia than DM diagnosed in adulthood, thus leading to higher odds of progression to short-term and long-term detrimental complications, such as kidney lesions and cardiovascular diseases [10, 11]. Although several studies have suggested an association between DM (T1DM or T2DM) in children and early-onset kidney disease later in life, the empirical evidence remains inconclusive due to a relatively small number of DM cases, the representation of participants only recruited from diabetes centers, cross-sectional study design, and crude definition of nephropathy defined only according to the presence of microalbuminuria [12,13,14,15,16,17,18,19,20]. Besides, limited research on type-specific kidney diseases mainly focused on renal failure [15] and several studies have addressed end-stage renal disease in particular [19, 21,22,23,24,25,26,27]. However, the findings on the association between ages of diagnosis of DM (5–9 years vs. 10–14 years) and rate of end-stage renal disease were inconsistent [19, 23, 24]. Moreover, little is known about the effects of DM types in childhood on other type-specific kidney diseases, such as glomerular diseases and renal tubulo-interstitial diseases later in life, particularly taking into consideration the age of DM diagnosis, sex, and duration of DM. A better understanding of such association is imperative to prevent and control subsequent adverse kidney complications.

In this large-scale population-based cohort study, we aimed to assess the associations of childhood T1DM and T2DM with subsequent overall and type-specific early-onset kidney diseases including glomerular diseases, renal tubulo-interstitial diseases, renal failure, urolithiasis, injury of kidney, and other disorders of kidney and ureter, taking into consideration sex, age at diagnosis of DM, and duration of DM.

Methods

Study population and procedures

The unique personal identification number in the Danish Civil Registration System was used to accurately merge individual data from all national registers in Denmark [28]. A total of 102,916 participants aged 0–17 years born between January 1977 and December 2016 were included in this study, i.e., 9356 children with DM (8470 for T1DM and 886 for T2DM) from the Danish National Patient Register and 93,560 randomly selected children without DM (a ratio of 1:10 individually matched by sex and birth year) from the general population. Additional file 1: Fig. S1 shows the flow chart of inclusion and exclusion of study participants. The study was approved by the Data Protection Agency (record number 2013–41-2569). By Danish law, no informed consent is required for a register-based study of anonymized data.

We performed sibling comparison analyses to control for the influence of unmeasured familial and shared genetic characteristics [29, 30]. A sub-sample of 6908 families including 17,315 siblings born to the same mother discordant for both DM and subsequent kidney diseases contributed to the effect estimate. The date of diagnosis of siblings in the DM exposure group was used as the start date for both groups. The follow-up period of all included participants was from the date of DM diagnosis in the exposure group until the first diagnosis of kidney disease, emigration, or 31 December 2018, whichever came first.

Exposure

Data on DM were from the Danish National Patient Registry, the Danish National Diabetes Register, and the Danish National Prescription Registry. We defined T1DM and T2DM as any first inpatient or outpatient visit with the diagnosis based on the International Classification of Disease (ICD) codes and prescription of anti-diabetic medicine by Anatomical Therapeutic Chemical (ATC) classification codes (T1DM: ICD-10 E10-E10.9, O24.0; ICD-8 249, ATC A10A; T2DM: ICD-10 E11-E119, O24.1; ICD-8 250, ATC A10B) (Additional file 1: Table S1). If one was diagnosed with both T1DM and T2DM, he/she was classified as the first type diagnosed DM. It should be noted that 91.0% of children with diabetes (T1DM or T2DM) had been mainly treated with insulin and its analogs, biguanides, and other drugs. Among all treated pediatric patients with T1DM, the proportions were 99.0% for the use of insulin and its analogs, 0.4% for biguanides, and 0.6% for other drugs. Among all treated pediatric patients with T2DM, the proportions were 43.6% for the use of insulin and its analogs, 50.4% for biguanides, and 6.0% for other drugs.

Outcome of interest

Early-onset kidney disease in childhood or adulthood was identified at the first hospital diagnosis of glomerular diseases, renal tubulo-interstitial diseases, renal failure, urolithiasis, injury of the kidney, and other disorders of the kidney and ureter based on the Danish National Patient Register by using ICD-8 and ICD-10 codes (Additional file 1: Table S1).

Covariates

Potential covariates used for adjustment included birthweight category (low, high, normal, or unknown), preterm birth (yes vs. no), parity (1, 2, or ≥ 3), singleton status (yes vs. no), residence (Copenhagen, cities with 100,000 or more inhabitants, or others), maternal marital status (unmarried, married, or unknown), maternal and paternal education levels (0–9 years, 10–14 years, ≥ 15 years, or unknown), and maternal and paternal history of DM (yes vs. no).

Statistical analyses

Continuous variables were presented as mean ± standard deviation (SD) or median with interquartile range (P25–P75) and mean rank, and categorical variables were presented as frequency (percentage). Considering non-kidney disease deaths as the competing event, competing risk analysis was used to calculate the cumulative incidence between children with and without DM. Stratified Cox proportional regression analysis with inverse probability of treatment weighting was used to estimate the associations of childhood TIDM/T2DM with kidney diseases later in life after adjustment for the aforementioned covariates. We performed subgroup analyses stratified by sex, child age at diagnosis of DM (0–5, 6–12, and 13–17 years), diabetic duration (0–10, 11–20, and ≥ 21 years), calendar periods (1977–1985 vs. 1986–2016), and DM complications (≥ 1 complications vs. 0 complications). We performed sensitivity analyses to examine these associations including (1) the use of sibling sub-cohort design with stratified Cox proportional regression analyses to take into account the influence of unmeasured genetic and environmental characteristics [29], (2) the exclusion of 1-year, 3-year, and 5-year duration of DM from exposed the group to examine the potential detection bias of DM [18]; (3) the exclusion of DM patients in childhood without the use of hypoglycemic drugs (9.0%) to examine whether this therapy influenced the association; and (4) further adjustment for the use of nephroprotective therapy to examine whether this variable influenced the association. We used multiple imputation procedures to impute missing values of all covariates of interest for final data analyses. All analyses were performed using SAS version 9.4. A two-sided p-value < 0.05 was considered statistically significant.

Results

Table 1 shows the baseline characteristics of participants by DM type. Children with DM were more likely to have low and high birth weight, preterm birth, lower maternal and paternal educational level, and parental history of DM before childbirth compared with children without DM. Similar results were found for most of these variables in children with T2DM compared with those with T1DM.

Table 1 Baseline characteristics of included participants by diabetes status
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Associations of childhood DM with overall and type-specific early-onset kidney diseases

During a median follow-up of 13 years, 340 children with DM (T1DM: 283, T2DM: 57) and 1376 children without DM were diagnosed with kidney disease. The cumulative incidence of any kidney diseases among individuals with DM was higher than those without DM, and the cumulative incidence seemed slightly higher in T2DM than in T1DM (Fig. 1). Children with DM had a 154% increased risk of early-onset kidney diseases, compared with children without DM (adjusted hazard ratios [aHR] 2.54, 95% confidence intervals 2.38–2.72). Both T1DM (2.48, 2.31–2.67) and T2DM (2.75, 2.28–3.31) were associated with an increased risk of overall kidney diseases. The risks for type-specific kidney diseases, in particular for glomerular disease (aHR = 3.56, 95% CI = 2.97–4.27), renal tubulo-interstitial diseases (aHR = 2.74, 95% CI = 2.48–3.02), renal failure (aHR = 9.13, 95% CI = 7.49–11.14), and urolithiasis (aHR = 1.39, 95% CI = 1.20–1.61) among children with DM, were also increased (Table 2). Similar patterns were found for T1DM and T2DM while the magnitude of associations seemed slightly stronger in children with T2DM than in those with T1DM (Table 2). Analyses stratified by sex showed similar results for any kidney diseases, glomerular disease, renal tubulo-interstitial disease, and renal failure. We observed an increased risk of urolithiasis among females with DM (1.93, 1.61–2.31) but not among males with DM (0.92, 0.71–1.19) (Additional file 1: Table S2).

Fig. 1
figure 1

Cumulative incidence of overall early-onset kidney diseases later in life among children divided into three groups (without DM, with T1DM, and with T2DM). DM, diabetes mellitus; T1DM, type 1 diabetes mellitus; T2DM, type 2 diabetes mellitus

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Table 2 Adjusted hazard ratios (95% confidence intervals) of overall and type-specific early-onset kidney diseases later in life for children with diabetes
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Associations of childhood DM with early-onset kidney diseases by calendar years, age of DM diagnosis, DM types, DM duration, and DM complications

The results for DM and overall and specific types of early-onset kidney diseases were stable during different calendar periods (1977–1985 vs. 1986–2016) (Additional file 1: Table S3). When we stratified the age of DM diagnosis, older exposed children at 6–12 years or 13–17 years were more likely to have a higher rate of kidney disease than younger children at 0–5 years (Fig. 2 and Additional file 1: Table S4). Similar results were found according to DM types (Additional file 1: Fig. S2 and Fig. S3). We found that children with longer DM duration (10–20 years and ≥ 21 years vs. 0–10 years) were at a higher increased risk of kidney diseases (Additional file 1: Table S5). Children with DM in combination with more than one diabetic complications (vs. without diabetic complication) tended to have a higher risk of kidney diseases later in life (Additional file 1: Table S6).

Fig. 2
figure 2

Cumulative incidence of overall early-onset kidney diseases later in life among children by age of diagnosis of diabetes mellitus (0–5, 6–12, and 13–17 years)

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Sensitivity analyses

The results from the sibling cohort were similar to the main results from the general population cohort (Additional file 1: Table S7). After excluding children with follow-up after a diagnosis of DM less than 1 year, 3 year, and 5 year, the results also remained stable (Additional file 1: Table S8). After further excluding DM patients in childhood without the use of hypoglycemic drugs also did not substantially change the findings (Additional file 1: Table S9). After further adjustment for the use of nephroprotective therapy, the results also remained consistent (Additional file 1: Table S10).

Discussion

Our study showed that children with T1DM or T2DM had an increased risk of overall and type-specific early-onset kidney diseases than those without DM. Older children who received a diagnosis of DM at 6–17 years (vs. younger children with DM diagnosed at 0–5 years) and children with longer DM duration (vs. shorter DM duration) were more likely to have overall and type-specific early-onset kidney diseases later in life. Females with DM were more likely to have urolithiasis, whereas males were not.

Several previous studies have reported that the overall risks of kidney diseases increased in young people with DM [15, 17, 31]. However, little is known about the association of DM with type-specific kidney diseases later in life. A cohort study based on 342 Canadian youths showed that DM was associated with an increased risk of renal failure compared with non-DM [15]. However, only a small number of individuals (365 with T1DM and 56 with T2DM) were followed up for more than 10 years. Although several previous studies in Norway, Sweden, and Finland showed that children or young people with DM had an increased risk of end-stage renal disease [19, 23,24,25], evidence is scarce on the cumulative risks of other kidney diseases for young people with DM. In this study, we used nationwide data in Denmark and confirmed that children with DM had an increased overall risk of kidney diseases, and we firstly reported that children with either type of DM had an increased risk of type-specific kidney diseases including glomerular disease, renal tubulo-interstitial disease, renal failure, and urolithiasis. Exposure to hyperglycemia could drive the loss of kidney function, influencing both renal tubulointerstitial and glomerular filtration barriers through increased oxidative stress, cell apoptosis, tissue fibrosis, and inflammation [32]. Our findings support that it is imperative to achieve and maintain glycemic control in youths [33] to prevent overall and type-specific early-onset kidney outcomes later in life. It is documented that improved glucose control may be useful for delaying the onset and progression of early complications of DM (including T1DM and T2DM) [34, 35]. Parental involvement in school and social settings, anticipation of poorer adherence and glucose control in youth with DM, a concern of depression symptoms, and appropriate health care services may help manage glucose more optimally [36].

The study based on 4555 children and adolescents from a young diabetes registry showed that the incidence rate of nephropathy per 1000 person-years increased with the duration of T1DM and T2DM [31]. However, this study was only based on a tertiary care private DM center in India, which might not be generalized to other populations [31]. Moreover, the effects of youth-onset DM on type-specific kidney diseases were not investigated. Two previous studies showed that both young and old people with a longer duration of DM had an increased risk of end-stage kidney disease [19, 27], but data on other type-specific kidney diseases are lacking. In this study, we found that the risks of kidney diseases overall and specific types (including renal failure, glomerular diseases, renal tubulo-interstitial disease, and urolithiasis) increased with the DM duration. Besides, we found that renal tubulo-interstitial disease and renal failure may occur with a short DM duration of fewer than 10 years, which suggest that it is important to keep healthy blood glucose level earlier to prevent these kidney diseases later in life.

Interestingly, similar to previous studies on the association between T2DM and long-term end-stage kidney disease in Canadian and Australian young adults [27, 37], we found that DM diagnosed at 0–5 years afforded lower cumulative incidence of all kidney diseases than DM diagnosed at 6–12 years and 13–17 years, independent of types of DM. Data from the Swedish Childhood Diabetes Register showed that the cumulative incidence of end-stage kidney disease for T1DM diagnosed at 0–9 years was lower than that diagnosed at 10–19 years [19]. However, this study did not compare the rate of end-stage kidney disease between T1DM diagnosed at 0–5 years and that at 5–9 years. In Norwegian children, the cumulative incidence of end-stage kidney disease for T1DM diagnosed at 0–5 years and 5–9 years was lower than that diagnosed at 10–14 years [24], whereas in Finnish children, the cumulative incidence of end-stage kidney disease for T1DM diagnosed at 0–4 years was lower than that diagnosed at 5–9 years and 10–14 years [23]. Our findings on the age of diagnosis of DM and cumulative incidence of all kidney diseases were similar to the latter one. The higher cumulative incidence of kidney diseases for diagnosed DM at 6–17 years compared with diagnosis at 0–5 years might be due to that sexual maturation caused by psychological and endocrine factors at puberty appears to accelerate the progress of DM, reflux nephropathy, and posterior urethral valves [38]. Moreover, the large psychological changes in puberty might influence the adherence to DM treatment [39], which poses a challenge to achieving good DM care for youths with DM. Besides, other risk factors including a rapid increase in body weight and blood pressure and altered endocrine during the puberty period also influence the development of chronic kidney disease [38]. In general, detecting DM in early childhood might be important for physicians helping them improve glycemic control, increase monitoring intensity, and delay long-term DM complications. It has been demonstrated that DM diagnosed at a young age might contribute to a delay in the development of end-stage kidney disease [23, 24].

Although several studies reported a higher or similar incidence of renal complications in T1DM than that in T2DM [12, 40, 41], a large number of emerging studies have shown that youths with T2DM had a higher burden of renal complications (especially end-stage kidney diseases or renal failure) and poor prognosis than those with T1DM [15, 17, 31, 40, 42]. The discrepancy of previous studies might be due to the differences in age and ethnicity/race of study participants, study sample size, the definition of DM, duration of follow-up years, and various renal complications (such as kidney risk profile, renal failure, and diabetic kidney diseases). In this study, we found that children with T1DM or T2DM had a similar increased overall risk of kidney disease, renal tubulo-interstitial disease, and urolithiasis compared with those without DM. The similarity in the risks of type-specific kidney diseases due to T1DM and T2DM implies shared pathological mechanisms between both types of DM in the development of kidney diseases [32]. However, the odds of glomerular disease and kidney failure among children with T2DM were nearly twice the odds among those with T1DM. Our findings might partly explain the discrepancy of previous findings. Although the potential mechanisms have not been elucidated, obesity, which causes T2DM, might play an important role in the formation of these kidney diseases [43, 44]. Besides, it might be driven by other major risk factors such as hypertension and dyslipidemia [45].

We found a similar risk of glomerular disease for youth-onset DM among both males and females, which was in line with the finding on the association between childhood-onset T1DM and end-stage kidney disease in a nationwide study in Sweden [25], but inconsistent with the finding of a markedly higher risk of end-stage kidney disease for the onset of DM among Australian males at 10–29 years vs. females and among Swedish males at 20–34 years vs. females [25, 27]. We additionally observed that females with DM were more likely to have urolithiasis, whereas males were not. Previous evidence has indicated that pediatric nephrolithiasis was more common in females than in males [46]. These findings might be explained by the fact that females had more acquisition of bone mineralization driven by estrogen, which might cause the formation of urine chemistry and stone [47]. At the start of puberty, females had higher levels of urinary citrate than males [48]. These findings imply that sex plays a vital role in the development of urolithiasis among children with DM, and further studies are warranted to understand the mechanism. However, we could not assess the sex effect on the association between childhood DM types and type-specific kidney diseases due to limited cases when stratified by sex, which needs further exploration.

To our knowledge, this was the first nationwide prospective study that offered new insights into the incidence of type-specific kidney diseases later in life for children with T1DM or T2DM. Additionally, we performed sibling design to assess the influence of unmeasured genetic and environmental characteristics, which are difficult to adjust using a conventional cohort study design. Several limitations deserved consideration. First, the small numbers of some type-specific kidney outcomes precluded us from performing subgroup analyses. Second, although several confounders have been adjusted in this study, confounding effects of some unadjusted factors cannot be ruled out, such as obesity status and lifestyles in childhood or adulthood. Third, the same code (ICD-8, 205) of T1DM and T2DM before 1986 might cause potential misclassification bias because children with T2DM who required insulin treatment might be misclassified as T1DM. However, our subgroup analyses stratified by calendar periods yielded a similar association between DM and the overall risk of kidney diseases between 1977–1985 and 1986–2016. Fourth, the use of ICD codes might underestimate the incidence of chronic kidney disease in administrative data because of inadequate documentation in discharge summaries and/or inaccurate coding practice [49]. However, we used both Danish-modified ICD-10 codes, ICD-8 codes, and ATC codes to capture kidney diseases. Fifth, we only examined the risk of kidney diseases in childhood and early adulthood because of the short follow-up duration (median: 13 years), and limited follow-up duration in our study might omit young children born in 1996–2016 who had a high risk of T2DM in adolescence. Future well-designed cohort studies with longer follow-up duration are warranted.

Conclusions

In conclusion, we found that childhood DM (both T1DM and T2DM) could lead to an increased risk of early-onset kidney diseases overall and a number of specific types, such as glomerular disease, renal tubulo-interstitial disease, and renal failure later in life. Older children who received a diagnosis of DM during later childhood were at a higher risk of developing kidney diseases compared with those during early childhood. Youth-onset DM with a longer duration was associated with a higher increased risk of overall and type-specific early-onset kidney diseases later in life. These findings highlight the significance of early detection and prevention of T1DM and T2DM among children at high risk because of prolonged exposure and stress and the importance of strict control of DM in the life course to reduce the high burden of kidney disease later in life.

Availability of data and materials

Data collected for this study and additional related documents will be available to others by contacting the corresponding author (Prof. Yongfu Yu, email: yu@fudan.edu.cn). Questions related to data availability should contact the senior author (Prof. Jiong Li, Email: jl@clin.au.dk ).

Change history

Abbreviations

aHR:

Adjusted hazard ratios

ATC:

Anatomical Therapeutic Chemical

DM:

Diabetes mellitus

ICD:

International Classification of Disease

SD:

Standard deviation

T1DM:

Type 1 diabetes mellitus

T2DM:

Type 2 diabetes mellitus

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Funding

This research was supported by the Shanghai Municipal Natural Science Foundation (22ZR1414900), Shanghai Rising-Star Program (21QA1401300), Shanghai Municipal Science and Technology Major Project (ZD2021CY001), Novo Nordisk Foundation (No. NNF18OC0052029), Danish Council for Independent Research (Nos. DFF-6110-00019B, DFF-9039-00010B, and DFF-1030-00012B), Nordic Cancer Union (No. R275-A15770 and R278-A15877), Karen Elise Jensens Fond (2016), and Natural Science Foundation of Shandong Province (No. ZR2021QH272). The funders had no role in the study design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation; review; or approval.

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Author notes

  1. Jiahong Sun and Ce Wang are the co-first authors.

Authors and Affiliations

  1. Department of Epidemiology, School of Public Health, Qilu Hospital, Cheeloo College of Medicine, Shandong University, 44 Wen Hua Xi Road, Jinan, 250012, Shandong, China

    Jiahong Sun & Bo Xi

  2. Department of Biostatistics, School of Public Health, and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, 130 Dong’an, Shanghai, 200032, China

    Ce Wang & Yongfu Yu

  3. Department of Nutrition and Food Hygiene, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China

    Min Zhao

  4. Department of Clinical Medicine-Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark

    Priscilla M. Y. Lee & Jiong Li

  5. Shanghai Institute of Infectious Disease and Biosecurity, Shanghai, China

    Yongfu Yu

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  1. Jiahong Sun
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  2. Ce Wang
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  3. Min Zhao
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Contributions

J.S. drafted the manuscript, contributed to the interpretation of the data, and revised the manuscript. Y.Y., B.X., and J.L. contributed to the study design and interpretation of the data analysis and revised the manuscript. P.L. and C.W. analyzed the data, contributed to the study design, and revised the manuscript. P.L. and J.L. accessed and verified the data and had full access to all the data in the study. M.Z. contributed to the interpretation of the data analysis and revised the manuscript. B.X., Y.Y., and J.L. had final responsibility for the decision to submit it for publication. The author(s) read and approved the final manuscript.

Corresponding authors

Correspondence to Bo Xi or Yongfu Yu.

Ethics declarations

Ethics approval and consent to participate

The study was approved by the Data Protection Agency (record number 2013–41-2569). By Danish law, no informed consent is required for a register-based study of anonymized data.

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Not applicable.

Competing interests

Bo Xi is a member of the BMC Medicine editorial board. None of the authors, including Bo Xi, had a role in the peer review or handling of this manuscript. The other authors declare that they have no competing interests.

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Supplementary Information

Additional file 1:

Supplementary results. Fig. S1. Flow chartof inclusion/exclusion of participants in this study. Fig. S2. Cumulative incidence of overall early-onset kidneydiseases later in life among children by age of diagnosis of type 1 diabetesmellitus (0-5, 6-12, and 13-17 years). Fig. S3. Cumulative incidence of overall early-onset kidney diseases later inlife among children by age of diagnosis of type 2 diabetes mellitus (0-5, 6-12,and 13-17 years). Table S1. International Classification of Diseases codes for diabetes mellitus and kidneydisease. Table S2. Associations ofchildhood diabetes with overall and type-specific early-onset kidney diseaseslater in life stratified for sex. TableS3. Associations of childhood diabetes with overall and type-specificearly-onset kidney diseases later in life stratified for periods of birth. Table S4. Associations of childhooddiabetes with overall and type-specific early-onset kidney diseases later inlife stratified for diagnosed age. TableS5. Associations of childhood diabetes with overall and type-specificearly-onset kidney disease later in life stratified for diabetes duration. Table S6. Associations of childhooddiabetes with overall and type-specific early-onset kidney disease later inlife stratified for number of diabetic complications. Table S7. Associations of childhood diabetes with overall andtype-specific early-onset kidney diseases later in life using a sibling design.Table S8. Associations of childhooddiabetes with overall and type-specific early-onset kidney diseases later inlife after excluding participants with one, three, or five years of diabetesduration. Table S9. Associations ofchildhood diabetes with overall and type-specific early-onset kidney diseaselater in life after exclusion of those without the use of hypoglycemic drugs. Table S10. Associations of childhooddiabetes with overall and type-specific early-onset kidney diseases later inlife after further adjustment for the use of nephroprotective therapy.

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Sun, J., Wang, C., Zhao, M. et al. Childhood diabetes mellitus and early-onset kidney diseases later in life: a nationwide population-based matched cohort study. BMC Med 20, 428 (2022). https://doi.org/10.1186/s12916-022-02634-4

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