Fig. 3
The significant differences in blood neutrophil percentage between the cognitively stable and cognitively progressive groups with CSD at baseline. NS adj p > 0.05, *adj p < 0.05 (A). The relative risk of cognitive progression was greater than 1.0 for the neutrophil (%) threshold of 61.633, and the relationship between neutrophil (%) and the corresponding HR was linear above this threshold in CSD subjects (B1), but there was no such relationship in normal sleep subjects (B2). Through the Cox proportional hazards model, blood neutrophil percentage was a risk factor for cognitive progression in the CSD group (C1) but not in the normal sleep group (C2). A Kaplan–Meier curve showing that subjects with higher blood neutrophil percentages were associated with a higher risk of cognitive progression (D). Spearman test showed that neutrophil percentage and neutrophil group correlated with CSF AD biomarker levels, baseline cognitive function, and annual changes in cognitive function, including ADAS-cog, MoCA, MMSE, FAQ, and MEM. *adj p < 0.05 (E)