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Table 2 Hierarchical regression in all the subjects

From: Neutrophil activation may trigger tau burden contributing to cognitive progression of chronic sleep disturbance in elderly individuals not living with dementia

Dependent variable

Independent variables

Unstandardized coefficient (95% CI)

Standardized coefficient

Model

R2

R2 change

Sig p value

FAQ-slope

Age

0.002 (0.000, 0.003)

0.088

    

Education

− 0.005 (− 0.008, − 0.002)

− 0.106

    

Sex

− 0.013 (− 0.028, 0.003)

− 0.051

    

APOE ε4

0.057 (0.042, 0.072)

0.227

Model 1

0.078

  

Neutrophil (%)

0.002 (0.001, 0.003)

0.122

Model 2

0.092

0.014

< 0.001

ADAS-cog

Age

0.002 (0.001, 0.003)

0.097

    

Education

− 0.003 (− 0.006, 0.000)

− 0.056

    

Sex

− 0.008 (− 0.025, 0.009)

− 0.028

    

APOE ε4

0.074 (0.057, 0.090)

0.266

Model 1

0.085

  

Neutrophil (%)

0.001 (0.000, 0.002)

0.072

Model 2

0.090

0.005

0.023

MMSE-slope

Age

− 0.001 (− 0.002, 0.000)

− 0.103

    

Education

0.002 (0.001, 0.004)

0.091

    

Sex

0.006 (− 0.002, 0.015)

0.048

    

APOE ε4

− 0.030 (− 0.039, − 0.022)

− 0.227

Model 1

0.077

  

Neutrophil (%)

− 0.001 (− 0.001, 0.000)

0.106

Model 2

0.088

0.011

0.001

MEM-slope

Age

0.000 (0.000, 0.000)

− 0.103

    

Education

0.000 (0.000, 0.001)

0.091

    

Sex

0.001 (0.000, 0.002)

0.048

    

APOE ε4

− 0.005 (− 0.006, − 0.004)

− 0.227

Model 1

0.124

  

Neutrophil(%)

0.001 (0.000, 0.002)

− 0.106

Model 2

0.132

0.008

0.004

  1. Model 1: demographics including age, sex, education, and APOE
  2. Model 2: demographics and blood neutrophil percentage