- Research article
- Open Access
- Open Peer Review
A review of the methodological features of systematic reviews in maternal medicine
© Sheikh et al; licensee BioMed Central Ltd. 2007
- Received: 07 August 2006
- Accepted: 24 May 2007
- Published: 24 May 2007
In maternal medicine, research evidence is scattered making it difficult to access information for clinical decision making. Systematic reviews of good methodological quality are essential to provide valid inferences and to produce usable evidence summaries to guide management. This review assesses the methodological features of existing systematic reviews in maternal medicine, comparing Cochrane and non-Cochrane reviews in maternal medicine.
Medline, Embase, Database of Reviews of Effectiveness (DARE) and Cochrane Database of Systematic Reviews (CDSR) were searched for relevant reviews published between 2001 and 2006. We selected those reviews in which a minimum of two databases were searched and the primary outcome was related to the maternal condition. The selected reviews were assessed for information on framing of question, literature search and methods of review.
Out of 2846 citations, 68 reviews were selected. Among these, 39 (57%) were Cochrane reviews. Most of the reviews (50/68, 74%) evaluated therapeutic interventions. Overall, 54/68 (79%) addressed a focussed question. Although 64/68 (94%) reviews had a detailed search description, only 17/68 (25%) searched without language restriction. 32/68 (47%) attempted to include unpublished data and 11/68 (16%) assessed for the risk of missing studies quantitatively. The reviews had deficiencies in the assessment of validity of studies and exploration for heterogeneity. When compared to Cochrane reviews, other reviews were significantly inferior in specifying questions (OR 20.3, 95% CI 1.1–381.3, p = 0.04), framing focussed questions (OR 30.9, 95% CI 3.7- 256.2, p = 0.001), use of unpublished data (OR 5.6, 95% CI 1.9–16.4, p = 0.002), assessment for heterogeneity (OR 38.1, 95%CI 2.1, 688.2, p = 0.01) and use of meta-analyses (OR 3.7, 95% CI 1.3–10.8, p = 0.02).
This study identifies areas which have a strong influence on maternal morbidity and mortality but lack good quality systematic reviews. Overall quality of the existing systematic reviews was variable. Cochrane reviews were of better quality as compared to other reviews. There is a need for good quality systematic reviews to inform practice in maternal medicine.
- Cochrane Review
- Language Restriction
- Methodological Feature
- Current Systematic Review
- Good Methodological Quality
Maternal medicine has emerged as an increasingly important area for the obstetricians dealing with high risk pregnancies. It involves care of women with medical complications of pregnancy which may be specific to or predate the pregnancy . Approximately half of complex pregnancies are related to an abnormal fetal or obstetric factor, whereas medical diseases constitute the remainder of this high risk obstetric population. Scientific developments in internal or general medicine have led to newer diagnostic and therapeutic strategies to manage medical diseases. The physiological changes during pregnancy can affect not only the clinical presentation of a medical problem but may give rise to difficulties in diagnosing and managing these problems. In order to provide the best possible quality of care to women with complicated pregnancies obstetricians dealing with the high risk obstetric cases should have evidence based knowledge on the diagnostic, therapeutic and prognostic aspects of maternal medicine.
Recently there has been a proliferation of systematic reviews as one of the key tools for evidence-based medicine . As maternal medicine covers the issues related to pregnancy as well as general medicine, research evidence is scattered in the literature making it difficult to access information for clinical decision making. Systematic reviews provide a way forward as individual pieces of research can be collected within literature reviews and if appropriate subjected to meta-analysis . Good methodological quality is essential for these reviews to have valid inferences and to produce usable evidence summaries to guide the obstetric management . This study examines the methodological features of recently published systematic reviews in maternal medicine and specifically compares Cochrane to non-Cochrane reviews.
A computerised search of publicly available databases was conducted. Ovid Medline (1996 to date), Embase (1996 to date), Database of Reviews of Effectiveness and Cochrane Database of Systematic Reviews were searched for relevant reviews published between 2001 and 2006. Key word combinations like Pregnan$, Matern$, Gestation$, Obstetric$, Complication$, Systematic review$ and Meta analys$ were used for the search strategy in addition to word variants, subject headings and free text. The $ sign is a truncator used to capture any word that begin with the letters in front of the $ sign in the search terms used. Additionally common and specific medical problems related to pregnancy were searched using key words describing names of the disease such as Pre eclampsia, Hypertension, Diabetes, Cholestasis, Anaemia, Thrombocytopaenia, Thrombophilia, and Thromboembolism. Hand search of reference lists was conducted of all relevant articles to identify any missing reviews. The searches were limited to reviews between 2001 and 2006 due to increasing developments in the field of maternal medicine in recent years. Inclusion criteria required a minimum of two publicly available databases searched for a medical condition specific to or predating pregnancy and maternal factor as the primary outcome. We searched without language restrictions. All the reviews with fetal or neonatal factor as the primary outcome were excluded.
Checklist used to assess the quality of systematic reviews included in the review.
Year of publication
Publication dates of literature included
No. studies included in the review
No. of reviewers
Type of review
Framing of question:
Narrow focus of question
Explicit testable hypothesis
Adequate search description (incl. names of databases and search terms)
Use of reference list
Search without language restriction
Assessment for risk of missing studies
Inclusion of unpublished data
Quality assessment of included studies:
Potential sources of bias (ie. randomisation)
Data collection (prospective/retrospective)
Blinding of assessors*
Description of intervention*
The quality of Cochrane and non Cochrane reviews is given in Fig 3. Cochrane reviews [8–46] had specified the questions more often than non Cochrane reviews [47–51, 53–55, 58–60, 62–71, 73–75] (OR 20.3, 95% CI 1.1–381.3, p = 0.04) and were also framed narrowly focussed questions specifying the population, interventions and comparisons, outcome of the study and the study design (OR 30.9, 95% CI 3.7- 256.2, p = 0.001). Cochrane reviews attempted more often to include unpublished data in literature search (OR 5.6, 95% CI 1.9–16.4, p = 0.002). Twelve out of 29 non-Cochrane reviews [48, 50, 53–55, 64–66, 68–71] performed a meta-analysis, but there was good awareness of where this technique was valuable and where it was not applicable. Meta analysis technique (OR 3.7, 95% CI 1.3–10.8, p = 0.02) and assessment for heterogeneity (OR 38.1, 95%CI 2.1, 688.2, p = 0.01) was found to be employed significantly more often by Cochrane reviews.
Our study showed that the Cochrane reviews [8–46] were of consistently high methodological quality and had a greater level of assessment for quality of included studies. They always did a meta-analysis [9, 12, 17, 19–25, 27–40, 44–46] where applicable. This is reassuring for clinicians who rely on them for decision-making. It is possible that the restriction on the length of published non Cochrane reviews by journals could have influenced their quality scores. However this issue has been addressed by increase in the web publishing of additional material in the electronic format by many journals in recent years.
This work has highlighted that literature searches in reviews are currently generally poor. A search that is not thorough risks giving biased inferences. We identified considerable room for improvement in certain methodological features of non Cochrane reviews. However all the selected reviews were similar in searches without language restriction and assessment for risk of missing studies. Interestingly use of reference list of the selected papers to identify any other eligible studies for inclusion in the review was found to be more frequent in non Cochrane reviews (OR 0.2, 95% CI 0.1–0.7, p < 0.007). This could be a result of the generic search strategy employed by Cochrane reviews with unclear mention of the use of reference lists in individual reviews. Cochrane reviews were found more likely to attempt to include unpublished data compared to non Cochrane reviews (OR 5.6, 95% CI 1.9–16.4, p < 0.002). This attempt to avoid publication bias is significant as the odds of publication are higher if the results are found to be significant compared to studies with non-significant results.
This study identified areas of maternal medicine that lack good quality systematic reviews. Majority of the reviews were on hypertensive disorders [8, 10, 11, 17, 19–23, 31–34, 37, 48, 53, 55, 58, 64, 65, 69, 70], psychiatry [15, 27, 43, 47, 50–52, 56, 57, 59, 61, 74, 75], or thromboembolism [26, 42, 62–66, 68]. Even among these commonly addressed areas, a very narrow spectrum of diseases was covered. For example reviews in psychiatry were solely focussed on depression during pregnancy and reviews in hypertension focussed mainly on pre eclampsia. Reviews for some very common medical problems during pregnancy were missing or of poor quality. We found very few reviews on diabetes mellitus [12, 39, 49, 73] and chronic hypertension and none on thyroid disorders.
With advancement in neonatology and paediatric medicine, more and more women with congenital problems such as congenital heart disease and inherited metabolic diseases are reaching child bearing age and considering pregnancy. There is an urgent need to have some cumulative evidence on management of this high risk group in the best possible way.
This study has some potential limitations. With our strict criteria to include reviews conducted with two publicly available databases, it is possible that some of the good quality reviews in maternal medicine using single database are missed. Another limitation relates to maternal outcome as the main focus of our study. We excluded all those reviews in which association between maternal disease and perinatal outcome was assessed. Keeping in mind the primary goal of an obstetrician being directed towards achieving a healthy and safe outcome for both mother and fetus, good quality evidenced based information on medical problems during pregnancy can only be achieved by reviewing methodological features of all aspects of maternal medicine irrespective of the endpoint. Due to the absence of blinding of the reviewers to the source of the review it is difficult to completely rule out any resultant bias.
Evidence based healthcare continues to make important contributions to the well being of pregnant women. This study has identified areas in maternal medicine that lack good quality systematic reviews. Overall quality of the existing systematic reviews was variable, with Cochrane reviews better than other reviews. To achieve better understanding and provide high quality obstetric care for pregnant women with medical problems, it is important to ensure that systematic reviews in maternal medicine are conducted to cover wider spectrum of diseases, and are reported at the highest possible quality.
- Department of Health: Specialised Services National Definition Set: 4 Specialised services for women's health. Department of health. 2006, [http://www.dh.gov.uk/en/PolicyAndGuidance/HealthAndSocialCareTopics/SpecialisedServicesDefinition]
- Oxman AD, Cook DJ, Guyatt GH: Users' guides to the medical literature. VI. How to use an overview. Evidence-Based Medicine Working Group. JAMA. 1994, 272: 1367-1371. 10.1001/jama.272.17.1367.View ArticlePubMedGoogle Scholar
- Sacks HS, Reitman D, Pagano D: Meta-analysis: an update. Mt Sinai J Med. 1996, 63: 216-224.PubMedGoogle Scholar
- Petticrew M: Systematic reviews from astronomy to zoology: myths and misconceptions. BMJ. 2001, 322: 98-101. 10.1136/bmj.322.7278.98.View ArticlePubMedPubMed CentralGoogle Scholar
- Clarke M: The QUORUM statement. Lancet. 2000, 355: 756-757. 10.1016/S0140-6736(05)72172-3.View ArticlePubMedGoogle Scholar
- Jadad AR, Cook DJ, Jones A, et al: Methodology and reports of systematic reviews and meta-analyses: a comparison of Cochrane reviews with articles published in paper-based journals. JAMA. 1998, 280: 278-280. 10.1001/jama.280.3.278.View ArticlePubMedGoogle Scholar
- Oxman AD, Guyatt GH: Validation of an index of the quality of review articles. J Clin Epidemiol. 1991, 44: 1271-1278. 10.1016/0895-4356(91)90160-B.View ArticlePubMedGoogle Scholar
- Abalos E, Duley L, Steyn DW, Henderson-Smart D: Antihypertensive drug therapy for mild to moderate hypertension during pregnancy. Cochrane Database of Systematic Reviews. 2001, CD002252-2Google Scholar
- Adab N, Tudur SC, Vinten J, Williamson P, Winterbottom J: Common antiepileptic drugs in pregnancy in women with epilepsy. Cochrane Database of Systematic Reviews. 2004, CD004848-3Google Scholar
- Atallah AN, Hofmeyr GJ, Duley L: Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database of Systematic Reviews. 2002, CD001059-1Google Scholar
- Bergel E, Carroli G, Althabe F: Ambulatory versus conventional methods for monitoring blood pressure during pregnancy. Cochrane Database of Systematic Reviews. 2002, CD001231-2Google Scholar
- Boulvain M, Stan C, Irion O: Elective delivery in diabetic pregnant women. Cochrane Database of Systematic Reviews. 2001, CD001997-2Google Scholar
- Brocklehurst P: Antibiotics for gonorrhoea in pregnancy. Cochrane Database of Systematic Reviews. 2002, CD000098-2Google Scholar
- Cuervo LG, Mahomed K: Treatment for iron deficiency anaemia in pregnancy. Cochrane Database of Systematic Reviews. 2001, CD003094-2Google Scholar
- Dennis CL, Creedy D: Psychosocial and psychological interventions for preventing postpartum depression. Cochrane Database of Systematic Reviews. 2004, CD001134-4Google Scholar
- Burrows RF, Clavisi O, Burrows E: Interventions for treating cholestasis in pregnancy. Cochrane Database of Systematic Reviews. 2001, CD000493-4Google Scholar
- Churchill D, Duley L: Interventionist versus expectant care for severe pre-eclampsia before term. Cochrane Database of Systematic Reviews. 2002, CD003106-3Google Scholar
- Dodd J, Dare MR, Middleton P: Treatment for women with postpartum iron deficiency anaemia. Cochrane Database of Systematic Reviews. 2004, CD004222-4Google Scholar
- Duley L, Henderson-Smart DJ: Drugs for treatment of very high blood pressure during pregnancy. Cochrane Database of Systematic Reviews. 2002, CD001449-4Google Scholar
- Duley L, Henderson-Smart D: Magnesium sulphate versus phenytoin for eclampsia. Cochrane Database of Systematic Reviews. 2003, CD000128-4Google Scholar
- Duley L, Henderson-Smart D: Magnesium sulphate versus diazepam for eclampsia. Cochrane Database of Systematic Reviews. 2003, CD000127-4Google Scholar
- Duley L, Gulmezoglu AM, Henderson-Smart DJ: Magnesium sulphate and other anticonvulsants for women with pre-eclampsia. Cochrane Database of Systematic Reviews. 2003, CD000025-2Google Scholar
- Duley L, Henderson-Smart D, Meher S: Altered dietary salt for preventing pre-eclampsia, and its complications. Cochrane Database of Systematic Reviews. 2005, CD005548-4Google Scholar
- French L, Smaill F: Antibiotic regimens for endometritis after delivery. Cochrane Database of Systematic Reviews. 2004, CD001067-4Google Scholar
- Garner P, Gulmezoglu A: Drugs for preventing malaria-related illness in pregnant women and death in the newborn. Cochrane Database of Systematic Reviews. 2002, CD000169-4Google Scholar
- Gates S, Brocklehurst P, Davis LJ: Prophylaxis for venous thromboembolic disease in pregnancy and the early postnatal period. Cochrane Database of Systematic Reviews. 2002, CD001689-2Google Scholar
- Howard LM, Hoffbrand S, Henshaw C, Boath L, Bradley E: Antidepressant prevention of postnatal depression. Cochrane Database of Systematic Reviews. 2005, CD004363-2Google Scholar
- Jewell D, Young G: Interventions for nausea and vomiting in early pregnancy. Cochrane Database of Systematic Reviews. 2002, CD000145-1Google Scholar
- Jewell D, Young G: Interventions for treating constipation in pregnancy. Cochrane Database of Systematic Reviews. 2001, CD001142-2Google Scholar
- Kroner C, Turnbull D, Wilkinson C: Antenatal day care units versus hospital admission for women with complicated pregnancy. Cochrane Database of Systematic Reviews. 2001, CD001803-4Google Scholar
- Magee L, Sadeghi S: Prevention and treatment of postpartum hypertension. Cochrane Database of Systematic Reviews. 2005, CD004351-1Google Scholar
- Magee LA, Duley L: Oral beta-blockers for mild to moderate hypertension during pregnancy. Cochrane Database of Systematic Reviews. 2003, CD002863-3Google Scholar
- Matchaba P, Moodley J: Corticosteroids for HELLP syndrome in pregnancy. Cochrane Database of Systematic Reviews. 2004, CD002076-1Google Scholar
- Meher S, Abalos E, Carroli G: Bed rest with or without hospitalisation for hypertension during pregnancy. Cochrane Database of Systematic Reviews. 2005, CD003514-4Google Scholar
- Orton L, Garner P: Drugs for treating uncomplicated malaria in pregnant women. Cochrane Database of Systematic Reviews. 2005, CD004912-3Google Scholar
- Quijano CE, Abalos E: Conservative management of symptomatic and/or complicated haemorrhoids in pregnancy and the puerperium. Cochrane Database of Systematic Reviews. 2005, CD004077-3Google Scholar
- Rumbold A, Duley L, Crowther C, Haslam R: Antioxidants for preventing pre-eclampsia. Cochrane Database of Systematic Reviews. 2005, CD004227-4Google Scholar
- Smaill F: Antibiotics for asymptomatic bacteriuria in pregnancy. Cochrane Database of Systematic Reviews. 2001, CD000490-2Google Scholar
- Tuffnell DJ, West J, Walkinshaw SA: Treatments for gestational diabetes and impaired glucose tolerance in pregnancy. Cochrane Database of Systematic Reviews. 2003, CD003395-3Google Scholar
- Vazquez JC, Villar J: Treatments for symptomatic urinary tract infections during pregnancy. Cochrane Database of Systematic Reviews. 2003, CD002256-4Google Scholar
- Walker GJ: Antibiotics for syphilis diagnosed during pregnancy. Cochrane Database of Systematic Reviews. 2001, CD001143-3Google Scholar
- Walker MC, Ferguson SE, Allen VM: Heparin for pregnant women with acquired or inherited thrombophilias. Cochrane Database of Systematic Reviews. 2003, CD003580-2Google Scholar
- Webb RT, Howard L, Abel KM: Antipsychotic drugs for non-affective psychosis during pregnancy and postpartum. Cochrane Database of Systematic Reviews. 2004, CD004411-2Google Scholar
- Young G, Jewell D: Interventions for preventing and treating pelvic and back pain in pregnancy. Cochrane Database of Systematic Reviews. 2002, CD001139-1Google Scholar
- Young G, Jewell D: Topical treatment for vaginal candidiasis (thrush) in pregnancy. Cochrane Database of Systematic Reviews. 2001, CD000225-4Google Scholar
- Young G, Jewell D: Interventions for leg cramps in pregnancy. Cochrane Database of Systematic Reviews. 2002, CD000121-1Google Scholar
- Boath E, Bradley E, Henshaw C, Boath E: The prevention of postnatal depression: a narrative systematic review. Journal of Psychosomatic Obstetrics & Gynecology. 2005, 26 (3): 185-192. 10.1080/01674820400028431.View ArticleGoogle Scholar
- Brien T, Ray JG, Chan WS: Maternal body mass index and the risk of pre eclampsia: a systematic overview. Epidemiology. 2003, 14 (3): 368-374. 10.1097/00001648-200305000-00020.View ArticleGoogle Scholar
- Brody SC, Harris R, Lohr K: Screening for gestational diabetes: a summary of the evidence for the U.S. Preventive Services Task Force. Obstetrics & Gynecology. 2003, 101 (2): 380-392. 10.1016/S0029-7844(02)03057-0.Google Scholar
- Beck CT: Predictors of postpartum depression: an update. Nursing Research. 2001, 50 (5): 275-285. 10.1097/00006199-200109000-00004.View ArticlePubMedGoogle Scholar
- Austin MP, Priest SR: Clinical issues in perinatal mental health: new developments in the detection and treatment of perinatal mood and anxiety disorders. Acta Psychiatrica Scandinavica. 2005, 112 (2): 97-104. 10.1111/j.1600-0447.2005.00549.x.View ArticlePubMedGoogle Scholar
- Beck CT: Postpartum depression: a metasynthesis. Qualitative Health Research. 2002, 12 (4): 453-472. 10.1177/104973202129120016.View ArticlePubMedGoogle Scholar
- Coomarasamy A, Papaioannou S, Gee H, Khan KS: Aspirin for the prevention of preeclampsia in women with abnormal uterine artery Doppler: a meta-analysis. Obstetrics & Gynecology. 2001, 98 (5 Pt 1): 861-866. 10.1016/S0029-7844(01)01569-1.Google Scholar
- Coomarasamy A, Honest H, Papaioannou S, Gee H, Khan KS: Aspirin for prevention of preeclampsia in women with historical risk factors: a systematic review. Obstetrics & Gynecology. 2003, 101 (6): 1319-1332. 10.1016/S0029-7844(03)00169-8.Google Scholar
- Conde-Agudelo A, Villar J, Lindhmeimer M: World health organization syustematic review of screening tests for pre eclampsia. Obstetrics & Gynecology. 2004, 104: 1367-1391.View ArticleGoogle Scholar
- Dennis CL: Preventing postpartum depression part II: A critical review of nonbiological interventions. Canadian Journal of Psychiatry – Revue Canadienne de Psychiatrie. 2004, 49 (8): 526-538.PubMedGoogle Scholar
- Dennis CL: Preventing postpartum depression part I: a review of biological interventions. Canadian Journal of Psychiatry – Revue Canadienne de Psychiatrie. 2004, 49 (7): 467-475.PubMedGoogle Scholar
- Duckitt K, Harrington D: Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies. BMJ. 2005, 330 (7491): 565-10.1136/bmj.38380.674340.E0.View ArticlePubMedPubMed CentralGoogle Scholar
- Eberhard-Gran M, Eskild A, Tambs K, Opjordsmoen S, Samuelsen SO: Review of validation studies of the Edinburgh Postnatal Depression Scale. Acta Psychiatrica Scandinavica. 2001, 104 (4): 243-249. 10.1034/j.1600-0447.2001.00187.x.View ArticlePubMedGoogle Scholar
- Gluck JC, Gluck PA: Asthma controller therapy during pregnancy. American Journal of Obstetrics & Gynecology. 2005, 192 (2): 369-380. 10.1016/j.ajog.2004.07.056.View ArticleGoogle Scholar
- Goodman JH: Postpartum depression beyond the early postpartum period. JOGNN – Journal of Obstetric, Gynecologic, & Neonatal Nursing. 2004, 33 (4): 410-420. 10.1177/0884217504266915.View ArticleGoogle Scholar
- Greer IA, Nelson-Piercy C: Low-molecular-weight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: a systematic review of safety and efficacy. Blood. 2005, 106 (2): 401-407. 10.1182/blood-2005-02-0626.View ArticlePubMedGoogle Scholar
- Kujovich JL: Thrombophilia and pregnancy complications. American Journal of Obstetrics and Gynecology. 2004, 191: 412-424. 10.1016/j.ajog.2004.03.001.View ArticlePubMedGoogle Scholar
- Kosmas IP, Tatsioni A, Ioannidis JP: Association of Leiden mutation in factor V gene with hypertension in pregnancy and pre-eclampsia: a meta-analysis. Journal of Hypertension. 2003, 21 (7): 1221-1228. 10.1097/00004872-200307000-00002.View ArticlePubMedGoogle Scholar
- Kosmas IP, Tatsioni A, Ioannidis JP: Association of C677T polymorphism in the methylenetetrahydrofolate reductase gene with hypertension in pregnancy and pre-eclampsia: a meta-analysis. Journal of Hypertension. 2004, 22 (9): 1655-1662. 10.1097/00004872-200409000-00004.View ArticlePubMedGoogle Scholar
- Kovalevsky G, Clarisa R, Gracia R, Jesse AB, Mary DS, Kurt TB: Evaluation of the association between hereditary thrombophilias and recurrent pregnancy loss: a meta-analysis. Archives Internal Medicine. 2004, 164: 558-562. 10.1001/archinte.164.5.558.View ArticleGoogle Scholar
- Kwon HL, Belanger K, Bracken MB: Effect of pregnancy and stage of pregnancy on asthma severity: a systematic review. American Journal of Obstetrics & Gynecology. 2004, 190 (5): 1201-1210. 10.1016/j.ajog.2003.09.057.View ArticleGoogle Scholar
- Lassere M, Empson M: Treatment of antiphospholipid syndrome in pregnancy – a systematic review of randomized therapeutic trials. Thrombosis Research. 2004, 114 (5–6): 419-426. 10.1016/j.thromres.2004.08.006.View ArticlePubMedGoogle Scholar
- Magee LA, Cham C, Waterman EJ, Ohlsson A, von DP: Hydralazine for treatment of severe hypertension in pregnancy: meta-analysis. BMJ. 2003, 327 (7421): 955-960. 10.1136/bmj.327.7421.955.View ArticlePubMedPubMed CentralGoogle Scholar
- Magee LA, Bull SB, Koren G, Logan A: The generalizability of trial data; a comparison of β-blockers in pregnancy. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2001, 94: 205-210. 10.1016/S0301-2115(00)00331-6.View ArticleGoogle Scholar
- Murphy VE, Clifton VL, Gibson PG: Asthma exacerbations during pregnancy: incidence and association with adverse pregnancy outcomes. Thorax. 2006, 61 (2): 169-176. 10.1136/thx.2005.049718.View ArticlePubMedPubMed CentralGoogle Scholar
- Rayburn WF, Bogenschutz MP: Pharmacotherapy for pregnant women with addictions. American Journal of Obstetrics & Gynecology. 2004, 191 (6): 1885-1897. 10.1016/j.ajog.2004.06.082.View ArticleGoogle Scholar
- Scott DA, Loveman E, McIntyre L, Waugh N: Screening for gestational diabetes: a systematic review and economic evaluation. Health Technology Assessment. 2002, 6 (11): 1-161.View ArticlePubMedGoogle Scholar
- Austin MP, Lumley J: Antenatal screening for postnatal depression: a systematic review. Acta Psychiatrica Scandinavica. 2003, 107 (1): 10-17. 10.1034/j.1600-0447.2003.02024.x.View ArticlePubMedGoogle Scholar
- Austin MP: Targeted group antenatal prevention of postnatal depression: a review. Acta Psychiatrica Scandinavica. 2003, 107 (4): 244-250. 10.1034/j.1600-0447.2003.00086.x.View ArticlePubMedGoogle Scholar
- Egger M, Smith GD: Meta-analysis bias in location and selection of studies. BMJ. 1998, 316: 61-66.View ArticlePubMedPubMed CentralGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1741-7015/5/10/prepub
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