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Responding to COVID-19: how an academic infectious diseases division mobilized in Singapore



On January 30, COVID-19 was declared a Public Health Emergency of International Concern—a week after Singapore’s first imported case and 5 days before local transmission. The National University Hospital (NUH) is Singapore’s third largest hospital with 1200 beds, heavy clinical workloads, and major roles in research and teaching.

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With memories of SARS still vivid, there was an urgent requirement for the NUH Division of Infectious Diseases to adapt—undergoing major reorganization to face rapidly changing priorities while ensuring usual essential services and standards. Leveraging on individual strengths, our division mobilized to meet the demands of COVID-19 while engaging in high-level coordination, strategy, and advocacy. We present our experience of the 60 days since the nation’s first case. During this time, our hospital has managed 3030 suspect cases, including 1300 inpatients, 37 confirmed cases, and overseen 4384 samples tested for COVID-19.


Complex hospital adaptations were supported by an unprecedented number of workflows and coordination channels essential to safe and effective operations. The actions we describe, aligned with international recommendations and emerging evidence-based best practices, may serve as a framework for other divisions and institutions facing the spread of COVID-19 globally.

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No part of the world will be spared from coronavirus disease 2019 (COVID-19), and every part of every health system needs to adapt. Infectious diseases (ID) physicians and divisions are no longer able to perform many of their usual clinical duties, nor undertake teaching and research as they have always done. There is an urgency to innovate in order to sustainably and safely provide all these essential services while stepping up to and confronting what for many is their raison d’etre. That is the challenge of responding to an emerging infectious disease, keeping pace with the dynamic developments of a pandemic, while designing and refining a seemingly endless number of workflows and policies in partnership with hospital leadership and others beyond the hospital.

This narrative is intended as a guide for ID physicians to help that adaption and to understand the expectations and needs that evolve. The strategy in Singapore, after the initial attempt at preventing local transmission, has been to prevent as many cases as possible and flatten the epidemic curve maximally [1]. Natural herd immunity is not a credible aim unless serological studies reveal unexpectedly high levels of asymptomatic transmission as in Iceland [2]. The endpoint of the outbreak must be an effective antiviral treatment or a vaccine [3]. In the meantime, lives are saved by a containment strategy with early case identification, isolation, and quarantine of close contacts, as well as having adequate hospital surge capacity to deal with spikes. This must be achieved while maintaining a high standard of care for those with COVID-19 as well ensuring our patients with non-COVID-19-related disease receive their usual care. We hope the actions we describe, aligned with international recommendations and emerging evidence-based best practices, may serve as a framework for other ID divisions facing the spread of COVID-19 globally [4].

Our colleagues in many countries may not have had the opportunity to prepare and adapt as we have in Singapore, which is a technologically advanced high-income country with a young highly mobile population. Lockdown is effective but not a permanent solution to contain the spread. Severe restriction of movements and activities will slow transmission and allow an overwhelmed health system to recover albeit slowly. Lockdown should be seen as a time to put in place the measures necessary to prevent a return to uncontrolled spread and, whether a country is early in its phase or overwhelmed, the following viewpoint may nevertheless apply.

Bracing for COVID-19—division strategy and leadership

On December 31, the World Health Organization (WHO) was informed of a likely novel respiratory pathogen in Wuhan, Hubei, China [5]. The following day, the Emergency Medicine Department (EMD) of the National University Hospital (NUH) began to screen for respiratory illness in returned travelers from Wuhan. As Singapore’s third largest hospital with 1200 beds, NUH serves as the referral center for the nation’s western region [6]. As an academic medical center, it is the primary teaching hospital for the Yong Loo Lin School of Medicine of the National University of Singapore and houses a full complement of tertiary and quaternary care services [7]. These services include those usually provided by a busy academic ID division with sixteen faculty members and four fellows in training [8].

Appreciating the strong economic, cultural, and familial ties between Singapore and China, Singapore anticipated early cases—with potential amplification by travel related to the Lunar New Year beginning on January 25 [9]. Informed by the experience from the severe acute respiratory syndrome (SARS) outbreak in 2003 [10] and tapping on ID expertise, hospital leadership met on January 5 to activate its emergency planning operations and command center. The ID division itself reorganized its operational structure to better meet the anticipated needs. Beyond the immediate leadership of the division, individuals were assigned critical leadership roles and empowered to act independently within the important communication paradigm to enable consistency and coordination (Table 1).

Table 1 Division of infectious diseases roles and key responsibilities in the COVID-19 response

Our strategy, in line with national direction, focused on enhanced screening, surveillance, and isolation of suspected cases [11], as well as ensuring the required resources and manpower were in place both for current needs and stepwise scale-up. We began daily leadership team meetings to review division deployment and operations and to coordinate with hospital stakeholders. An important early realization was that COVID-19-related operations had to be separated from others. This was done primarily through delegation of non-ID clinical work to non-ID faculty within the department of medicine who graciously stepped up to do this, as well as scaling down of routine outpatient consultations, adopting telehealth and home medication delivery. The leadership team needed to be protected from regular duties in order to focus solely and deliver on the pandemic response expectations for which timely response was paramount.

As daily tracking of isolation room capacity and personal protective equipment (PPE) was initiated at the hospital level and plans made for when the state of alert in Singapore was formally escalated, we drafted the first screening and isolation workflows, created PPE guidelines along with holding refresher PPE trainings and risk-stratifying the use of aerosol-generating procedures. We reviewed the early strategy and workflows, discussed the teaching and research activities that should be prioritized, and made a commitment that the division would be on the frontline of the COVID-19 response in whatever capacity was ultimately required. It was time to demonstrate the value of our chosen specialty, and as a division, we chose to make this our moment to shine.

Ramping up—diagnostic testing, surge isolation capacity, and manpower

On January 23, Singapore reported its first imported COVID-19 case [12]. During this period, a trickle of patients with a history of travel and acute respiratory illness (ARI), none particularly suspicious for COVID-19, had been isolated on admission to NUH and de-isolated based on SARS-CoV-2 PCR testing developed by Singapore’s National Public Health Laboratory (NPHL). The NPHL-based laboratory-developed test was a real-time PCR targeting the N and ORF1ab genes [13]. This test was validated and rolled out at NUH on February 3, and thereafter, we had independent capacity to test all necessary cases in house.

On February 4, when Singapore reported its first local cluster [14], NUH was therefore ready for two important actions. First, this permitted us to conduct once-off testing for SARS-CoV-2 of all current admitted patients with ARI. No cases of COVID-19 were found among the 66 swabs performed that day. This exercise ensured that no undetected cases were on our wards. It also tested the lab’s capacity (which quickly ramped up from 120 to 1600 tests per day) and turnaround time. Second, we implemented enhanced surveillance. From February 5 onwards, all patients admitted to our hospital with evidence of ARI, regardless of travel history, were tested for COVID-19 (Fig. 1). Pending results, patients were isolated in single rooms, rather than cohorted in available open cubicles, to prevent patient-to-patient transmission.

Fig. 1

Laboratory testing for SARS-CoV-2 at the National University Hospital

To accommodate the surge in isolation room requirements, our hospital’s two dedicated isolation wards, with a peacetime capacity of 42 negative pressure rooms, were decanted of existing patients (except for those requiring airborne isolation for other infections such as pulmonary tuberculosis or disseminated zoster) and converted into “pandemic wards.” An additional 3 wards with single rooms and dedicated bathrooms (1 with negative pressure and 2 with neutral pressure) in the private wing of the hospital were decanted and activated as pandemic wards in stages over the following 5 weeks to meet the incremental surge requirements (Fig. 2).

Fig. 2

a Incremental scale-up and occupancy of isolation capacity. b Pandemic ward admissions and discharges over time at the National University Hospital

Handling the expected surge of suspected and confirmed COVID-19 patients, while maintaining the department’s usual clinical services, was a major challenge. Our team segregated into 2 teams to minimize cross-exposure should a breech occur—a lesson learned from SARS when transmission in our hospital occurred in a non-SARS ward among general medical patients [15]. This resulted in a complex “pandemic roster” of up to 6 pandemic ward teams, which could be activated in stages and separated from the main roster. The first pandemic team was staffed by the ID division, with the remaining teams staffed by other medical specialties and augmented by an embedded ID specialist on each ward. The embedded ID attending helped incoming non-ID faculty and residents build familiarity with COVID-19-related care and workflows, approved all de-isolation decisions (typically clinical improvement plus 2 negative PCRs at least 24 h apart), reinforced appropriate PPE and other infection prevention practices, and served as a strategic link between the ID leadership team and inpatient frontlines.

Such a significant redeployment of manpower was made possible by a decision to defer non-urgent outpatient visits and routine follow-ups to all medical specialties—ultimately leading to a reduction across the department of medicine’s ambulatory workload of 50–70%. Our workforce was further freed up by the temporary cancelation of medical student teaching on February 7 and other non-clinical activities. To date, the pandemic teams have admitted more than 1300 patients with suspected or confirmed COVID-19 into the designated pandemic wards. They have been responsible not only for identifying and managing those with confirmed infection but, equally importantly, for maintaining flow through the pandemic wards by safely and efficiently de-isolating those without COVID-19. Only select patient groups with ARI, for example stem cell transplant patients, are cared for in consultation with ID in isolation beds within their units, ensuring they receive the specialist nursing care they require.

The clinical leaders meet daily to discuss and respond to hospital-wide concerns, troubleshoot problems, and provide a forum for feedback from the medical teams on the ground. We receive detailed isolation bed occupancy statistics and act quickly in response to admission spikes to avoid a bed-block situation. To maintain outflow from the pandemic wards, teams were granted priority and “disposition rights” to transfer with appropriate handover their de-isolated patients to any medical or surgical team best suited to the further care of the patients. Timely results became critical as isolation bed occupancy rates spiked. With strong support from the lab, ID advocated for in-house SARS-CoV-2 PCR testing to be scaled up from 2 to 3 runs a day to eventually 5 runs a day (with capacity for 300 tests per day). Starting on March 2, testing was conducted using a commercial kit (A*STAR Fortitude Kit 2.0, SARS CoV-2 RT-PCR Test, Agency for Science, Technology and Research, Singapore) with assays running from 7 am to midnight and a turnaround time of 6 h. Well patients were readied for anytime of the day or night discharges, which nurses were empowered to execute after checking for negative results.

To cope with increased flow into the pandemic wards, we advocated with EMD for extended screening capacity as well as a “swab-and-go” service for well patients with ARI to be screened and discharged home with instructions to self-isolate pending results. The service included patients being informed of negative results and instructions for further care via secure automated messaging, while positive results were notified by an ID physician, who arranged direct admission to one of the pandemic wards. As of March 23, 4384 SARS-CoV-2 tests have been conducted at our institution, on 3030 patients, with 37 (1.2%) confirmed COVID-19 cases. Of the total, 1982 tests (45.2%) have been performed in the EMD or outpatient setting. Of the 37 positive patients, 15 were tested under our EMD “swab-and-go” workflow.

On March 21, when our isolation bed occupancy rate reached a predetermined trigger point of 80% plus 10 inpatient COVID-19 cases, we opened a dedicated 32-bed open ward with 6-bed cubicles to cohort all COVID-19 patients, manned by an ID physician-led 6th pandemic team. Prior to opening the cohort ward, and with non-COVID-19 inpatients still present, a 4-h-long simulation was held, with staff wearing full PPE under observation, understanding the actions and movements necessary to maintain excellent infection prevention practices. This action reserved our isolation beds primarily for suspect cases that would be transferred to the cohort ward if confirmed positive. Infection prevention practices on this cohort ward remain a priority with an embedded infection prevention nurse who performs audits on a daily basis and provides feedback to the staff on the ground as well as to the hospital leadership.

An outbreak of workflows, meetings, and communications

An unprecedented number of workflows were developed from scratch, existing hospital pandemic drawer plans, or by adapting guidance and shared practices by Singapore’s National Centre for Infectious Diseases [16, 17] and Ministry of Health [18]. Creating, updating, and coordinating these in a necessarily collaborative way required a dedicated effort. By February 10, the workflows and guidelines developed were collated into a hospital-wide COVID-19 Emergency Preparedness and Response Plan, which was disseminated to all medical personnel at NUH, hosted on our intranet and continues to be built upon (Table 2).

Table 2 Workflows created for COVID-19 emergency preparedness and response plan

Communicating the COVID-19 response strategy and workflows became a key component of our regular operations. Once acceptance of any workflow or policy was agreed upon by stakeholders, channels of communication, including “town halls,” while large gathering were still permitted; huddles with key individuals; and WhatsApp® group chats with the pandemic teams, epidemiology teams, and others, permitted rapid dissemination of information and feedback. While public messaging applications are user-friendly, a hospital-approved, Health Insurance Portability and Accountability Act compliant messaging service is vital for patient-specific information. Such a dedicated service was utilized to rapidly share newly positive patients by the lab with the ID clinical and epidemiology teams; to discuss specialized pathways to be activated, including special routes of transfer; or to expedite laboratory testing for specific patients. Video and teleconferencing applications have also played a vital role in keeping lines of communication open between frontline staff and key stakeholders, especially when social distancing is encouraged, and can bring together stakeholders across institutions, allowing for close alignment of hospital policy and procedures across a health system.

Another key communications platform was the early institution of a 24-h telephone hotline manned by an ID attending, to ensure patients were right-sited into and out of pandemic wards, provide reassurance in the interpretation of complicated workflows, and allay anxieties which ranged from the management of unwell patients to feedback on infection control lapses. The “Coronavirus Consultant Hotline” remains an indispensable feature of our communications where not every situation can be captured via workflow. Since its inception on February 3, it has received an average of 45 calls per day.

Beyond technological communications, however, we found urgent face-to-face meetings or briefings were required to defuse situations involving heightened sensitivities. Such interactions were needed with departments facing staff exposures or concerns of higher risk by virtue of their work. Examples from our experience include anesthesiologists, pulmonary function lab staff, pathologists, and porters. Regardless of method, messaging needs to be consistent, accurate, and from someone trusted. It ideally should be delivered by a selected few whether it be to the media, hospital management, clinicians, or others. The fastest way to lose credibility (which impacts the capacity to succeed) is to provide poor or inaccurate information. Furthermore, contextualizing the information provided and acting on feedback is critical in communications.

Redefining our academic mission

The impact of COVID-19 on the academic priorities of our division cannot be overstated. As an academic division with a 3-year fellowship program, and active bench and clinical research programs, reorganization of this portfolio was urgently needed. An early decision was made to protect some of the time of the division’s three clinician-scientists to focus on COVID-19-related studies of diagnostic and treatment modalities. We committed as a group that while we might offer antiviral treatment on a compassionate basis to our patients with COVID-19, our goal was to ultimately participate in international, rigorously conducted randomized clinical trials. All agreed that despite exigencies of clinical service, duty to our patients included generating evidence that would meaningfully contribute to the field. This approach has so far led to five grants won, initiation of a specimen biobank and associated BSL2+ facility, four prospective cohort studies, and two interventional therapeutics RCTs.

Our division also committed to fully leverage on the unique learning opportunities afforded to our four ID fellows by the COVID-19 response. The division’s chief and clinical director worked closely with the fellowship program’s director and “chief fellow” on an incremental clinical surge roster for the fellows, balancing involvement on the pandemic teams with other required clinical experiences. Similar to the actions taken for ID faculty, this was further facilitated by a reduction of fellows’ routine outpatient workload. Regular structured didactics were replaced by just-in-time learning on topics ranging from how to keep abreast with the evidence being rapidly generated to basic epidemiology principles. COVID-19 also afforded rich case studies for faculty to teach professionalism and medical ethics in an outbreak setting such as public health exceptions to patient confidentiality, mandated isolation, and quarantine orders. As face-to-face group teaching was suspended to minimize transmission risk, we adapted to use teleconferencing and virtual chat groups for learning. Training was also rapidly implemented to mitigate risk of COVID-19 to fellows such as personal protective equipment refreshers, regular updates on hospital workflows, and protocols on managing suspected and confirmed cases. A concerted effort was made to extend standing invitations to our future ID specialists to the hospital’s high-level preparedness and response meetings.


Every city of every country is at a different phase of their own outbreak. Singapore has managed its outbreak response with a strong commitment to containing the virus to minimize social disruption. All suspect cases are admitted to hospital and isolated. Others are tested and allowed home with strict instructions to self-isolate until results are communicated to them, usually within hours. All confirmed cases remain isolated in hospital (or more recently, community isolation facilities) [19]. Close contacts and overseas arrivals are in strict quarantine. This is the practice in at least five countries, none of which is in a community transmission phase.

Overwhelmed countries with community transmission and under some degree of lockdown may not yet be able to implement much of what we have presented. However, as transmission is brought under control, there will be a need to adapt hospital workflows in a way similar to those described. The ID divisions will be called on to show leadership in every aspect of hospital function. There needs to be adaptability, agility, and strong leadership within the division. Each individual needs to understand their role, and do it well and fast. Everyone needs a colleague backup as no one can be indispensable. Decisions and policies need a blend of science and empathy, while communications and messaging are paramount. ID divisions globally are being tested, and this is our moment to shine.

Availability of data and materials

Not applicable



Acute respiratory illness


Coronavirus disease 2019


Infectious diseases


Emergency Medicine Department


National Public Health Lab


National University Hospital


Personal protective equipment


Severe acute respiratory syndrome


Severe acute respiratory syndrome coronavirus 2


World Health Organization


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We thank Xier Emily Yeo, MPH, and Wei Ting Chong for their assistance in creating the figures, as well as the NUH Epidemiology and Bed Management Units, for use of relevant data. We thank our colleagues in the department of medicine and all our fellow healthcare workers and support staff at the National University Health System. We are grateful for the support of our leadership and operations teams, and the recognition and generosity of our local businesses and community organizations.


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SA, GC, NB, JS, NT, and DAF wrote the manuscript with input and guidance from all co-authors. SA and GC contributed equally to the writing. All authors contributed to the activities described and writing of the manuscript, and approved the final version for publication.

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Correspondence to Sophia Archuleta or Gail Cross.

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Dale A. Fisher is an editorial board member of this journal. We declare no other competing interests.

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Archuleta, S., Cross, G., Somani, J. et al. Responding to COVID-19: how an academic infectious diseases division mobilized in Singapore. BMC Med 18, 179 (2020).

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  • COVID-19
  • Pandemic response
  • Academic infectious diseases