Gotwals P, Cameron S, Cipolletta D, Cremasco V, Crystal A, Hewes B, et al. Prospects for combining targeted and conventional cancer therapy with immunotherapy. Nat Rev Cancer. 2017;17(5):286–301. https://doi.org/10.1038/nrc.2017.17.
Article
CAS
Google Scholar
Sanmamed M, Chen LJC. A paradigm shift in cancer immunotherapy: from enhancement to normalization. Cell. 2018;175(2):313–26. https://doi.org/10.1016/j.cell.2018.09.035.
Article
CAS
Google Scholar
Chen D, Mellman IJI. Oncology meets immunology: the cancer-immunity cycle. Immunity. 2013;39(1):1–10. https://doi.org/10.1016/j.immuni.2013.07.012.
Article
CAS
Google Scholar
Rashdan S, Minna JD, Gerber DE. Diagnosis and management of pulmonary toxicity associated with cancer immunotherapy. Lancet Respir Med. 2018;6(6):472–8. https://doi.org/10.1016/s2213-2600(18)30172-3.
Article
CAS
Google Scholar
Wang DY, Salem J-E, Cohen JV, Chandra S, Menzer C, Ye F, et al. Fatal toxic effects associated with immune checkpoint inhibitors. JAMA. Oncol. 2018;4(12). https://doi.org/10.1001/jamaoncol.2018.3923.
Sears CR, Peikert T, Possick JD, Naidoo J, Nishino M, Patel SP, et al. Knowledge gaps and research priorities in immune checkpoint inhibitor–related pneumonitis. An Official American Thoracic Society Research Statement. Am J Respir Crit Care Med. 2019;200(6):e31–43. https://doi.org/10.1164/rccm.201906-1202ST.
Article
CAS
Google Scholar
Nishino M, Sholl LM, Hodi FS, Hatabu H, Ramaiya NH. Anti-PD-1-related pneumonitis during cancer immunotherapy. N Engl J Med. 2015;373(3):288–90. https://doi.org/10.1056/NEJMc1505197.
Article
CAS
Google Scholar
Nishino M, Giobbie-Hurder A, Hatabu H, Ramaiya NH, Hodi FS. Incidence of programmed cell death 1 inhibitor–related pneumonitis in patients with advanced cancer. JAMA Oncol. 2016;2(12):1607–10. https://doi.org/10.1001/jamaoncol.2016.2453.
Article
Google Scholar
Suzuki Y, Karayama M, Uto T, Fujii M, Matsui T, Asada K, et al. Assessment of immune-related interstitial lung disease in patients with NSCLC treated with immune checkpoint inhibitors: a multicenter prospective study. J Thorac Oncol. 2020;15(8):1317–27. https://doi.org/10.1016/j.jtho.2020.04.002.
Article
CAS
Google Scholar
Moey MYY, Gougis P, Goldschmidt V, Johnson DB, Lebrun-Vignes B, Moslehi J, et al. Increased reporting of fatal pneumonitis associated with immune checkpoint inhibitors: a WHO pharmacovigilance database analysis. Eur Respir J. 2020;55(6). https://doi.org/10.1183/13993003.00038-2020.
Palma DA, Senan S, Tsujino K, Barriger RB, Rengan R, Moreno M, et al. Predicting radiation pneumonitis after chemoradiation therapy for lung cancer: an international individual patient data meta-analysis. Int J Radiat Oncol Biol Phys. 2013;85(2):444–50. https://doi.org/10.1016/j.ijrobp.2012.04.043.
Article
Google Scholar
Marks LB, Bentzen SM, Deasy JO, Kong F-MS, Bradley JD, Vogelius IS, et al. Radiation dose–volume effects in the lung. Int J Radiat Oncol Biol Phys. 2010;76(3):S70–S6. https://doi.org/10.1016/j.ijrobp.2009.06.091.
Article
Google Scholar
Ding PN, Lord SJ, Gebski V, Links M, Bray V, Gralla RJ, et al. Risk of treatment-related toxicities from EGFR tyrosine kinase inhibitors: a meta-analysis of clinical trials of gefitinib, erlotinib, and afatinib in advanced EGFR-mutated non-small cell lung cancer. J Thorac Oncol. 2017;12(4):633–43. https://doi.org/10.1016/j.jtho.2016.11.2236.
Article
Google Scholar
Inoue A, Saijo Y, Maemondo M, Gomi K, Tokue Y, Kimura Y, et al. Severe acute interstitial pneumonia and gefitinib. Lancet. 2003;361(9352):137–9. https://doi.org/10.1016/s0140-6736(03)12190-3.
Article
Google Scholar
Porta C, Osanto S, Ravaud A, Climent MA, Vaishampayan U, White DA, et al. Management of adverse events associated with the use of everolimus in patients with advanced renal cell carcinoma. Eur J Cancer. 2011;47(9):1287–98. https://doi.org/10.1016/j.ejca.2011.02.014.
Article
CAS
Google Scholar
Naidoo J, Wang X, Woo KM, Iyriboz T, Halpenny D, Cunningham J, et al. Pneumonitis in patients treated with anti–programmed death-1/programmed death ligand 1 therapy. J Clin Oncol. 2017;35(7):709–17. https://doi.org/10.1200/jco.2016.68.2005.
Article
CAS
Google Scholar
Genestreti G, Di Battista M, Trisolini R, Denicolò F, Valli M, Lazzari-Agli LA, et al. A commentary on interstitial pneumonitis induced by docetaxel: clinical cases and systematic review of the literature. Tumori. 2018;101(3):e92–e5. https://doi.org/10.5301/tj.5000275.
Article
CAS
Google Scholar
Poole BB, Hamilton LA, Brockman MM, Byrd DC. Interstitial pneumonitis from treatment with gemcitabine. Hosp Pharm. 2014;49(9):847–50. https://doi.org/10.1310/hpj4909-847.
Article
Google Scholar
Jules-Elysee K, White DA. Bleomycin-induced pulmonary toxicity. Clin Chest Med. 1990;11:1. https://doi.org/10.1016/S0272-5231(21)00668-7.
Article
CAS
Google Scholar
Shaverdian N, Lisberg AE, Bornazyan K, Veruttipong D, Goldman JW, Formenti SC, et al. Previous radiotherapy and the clinical activity and toxicity of pembrolizumab in the treatment of non-small-cell lung cancer: a secondary analysis of the KEYNOTE-001 phase 1 trial. Lancet Oncol. 2017;18(7):895–903. https://doi.org/10.1016/s1470-2045(17)30380-7.
Article
CAS
Google Scholar
Theelen WSME, Peulen HMU, Lalezari F, van der Noort V, de Vries JF, Aerts JGJV, et al. Effect of pembrolizumab after stereotactic body radiotherapy vs pembrolizumab alone on tumor response in patients with advanced non-small cell lung cancer: results of the PEMBRO-RT Phase 2 Randomized Clinical Trial. JAMA Oncol. 2019;5(9):1276–82. https://doi.org/10.1001/jamaoncol.2019.1478.
Article
Google Scholar
Jing Y, Yang J, Johnson DB, Moslehi JJ, Han L. Harnessing big data to characterize immune-related adverse events. Nat Rev Clin Oncol. 2022:1-12. doi: https://doi.org/10.1038/s41571-021-00597-8
FDA’s Adverse Event Reporting System (FAERS). https://www.fda.gov/drugs/questions-and-answers-fdas-adverse-event-reporting-system-faers/fda-adverse-event-reporting-system-faers-public-dashboard. Accessed 4 Oct 2020.
Oshima Y, Tanimoto T, Yuji K, Tojo A. EGFR-TKI-associated interstitial pneumonitis in nivolumab-treated patients with non-small cell lung cancer. JAMA Oncol. 2018;4(8):1112–5. https://doi.org/10.1001/jamaoncol.2017.4526.
Article
Google Scholar
Shannon VR, Anderson R, Blidner A, Choi J, Cooksley T, Dougan M, et al. Multinational Association of Supportive Care in Cancer (MASCC) 2020 clinical practice recommendations for the management of immune-related adverse events: pulmonary toxicity. Supportive Care in Cancer. 2020;28(12):6145–57. https://doi.org/10.1007/s00520-020-05708-2.
Article
Google Scholar
Sakaeda T, Tamon A, Kadoyama K, Okuno Y. Data mining of the public version of the FDA Adverse Event Reporting System. Int J Med Sci. 2013;10(7):796–803. https://doi.org/10.7150/ijms.6048.
Article
CAS
Google Scholar
Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc B. 1995;57(1):289–300. https://doi.org/10.1111/j.2517-6161.1995.tb02031.x.
Article
Google Scholar
RStudio Team (2020). RStudio: integrated development for R. RStudio, PBC, Boston http://www.rstudio.com/. Accessed 4 Apr 2020.
Hamashima R, Uchino J, Morimoto Y, Iwasaku M, Kaneko Y, Yamada T, et al. Association of immune checkpoint inhibitors with respiratory infections: a review. Cancer Treat Rev. 2020;90:102109. https://doi.org/10.1016/j.ctrv.2020.102109.
Article
CAS
Google Scholar
Suresh K, Voong KR, Shankar B, Forde PM, Ettinger DS, Marrone KA, et al. Pneumonitis in non-small cell lung cancer patients receiving immune checkpoint immunotherapy: incidence and risk factors. J Thorac Oncol. 2018;13(12):1930–9. https://doi.org/10.1016/j.jtho.2018.08.2035.
Article
CAS
Google Scholar
Antonia SJ, Villegas A, Daniel D, Vicente D, Murakami S, Hui R, et al. Overall survival with durvalumab after chemoradiotherapy in stage III NSCLC. N Engl J Med. 2018;379(24):2342–50. https://doi.org/10.1056/NEJMoa1809697.
Article
CAS
Google Scholar
Anouti B, Althouse S, Durm G, Hanna N. Prognostic variables associated with improved outcomes in patients with stage III NSCLC treated with chemoradiation followed by consolidation pembrolizumab: a subset analysis of a phase II study from the Hoosier Cancer Research Network LUN 14-179. Clin Lung Cancer. 2020;21(3):288–93. https://doi.org/10.1016/j.cllc.2019.06.009.
Article
CAS
Google Scholar
Peters S, Felip E, Dafni U, Belka C, Guckenberger M, Irigoyen A, et al. Safety evaluation of nivolumab added concurrently to radiotherapy in a standard first line chemo-radiotherapy regimen in stage III non-small cell lung cancer—the ETOP NICOLAS trial. Lung Cancer. 2019;133:83–7. https://doi.org/10.1016/j.lungcan.2019.05.001.
Article
CAS
Google Scholar
Lin SH, Lin Y, Yao L, Kalhor N, Carter BW, Altan M, et al. Phase II trial of concurrent atezolizumab with chemoradiation in unresectable non-small cell lung cancer. J Thorac Oncol. 2019:1–31. https://doi.org/10.1016/j.jtho.2019.10.024.
Shah RR. Tyrosine kinase inhibitor-induced interstitial lung disease: clinical features, diagnostic challenges, and therapeutic dilemmas. Drug Saf. 2016;39(11):1073–91. https://doi.org/10.1007/s40264-016-0450-9.
Article
CAS
Google Scholar
Pozzessere C, Bouchaab H, Jumeau R, Letovanec I, Daccord C, Bourhis J, et al. Relationship between pneumonitis induced by immune checkpoint inhibitors and the underlying parenchymal status: a retrospective study. ERJ Open Res. 2020:1–11. https://doi.org/10.1183/23120541.00165-2019.
Voong KR, Hazell SZ, Fu W, Hu C, Lin CT, Ding K, et al. Relationship between prior radiotherapy and checkpoint-inhibitor pneumonitis in patients with advanced non-small-cell lung cancer. Clin Lung Cancer. 2019;20(4):e470–e9. https://doi.org/10.1016/j.cllc.2019.02.018.
Article
Google Scholar
Shaverdian N, Beattie J, Thor M, Offin M, Shepherd AF, Gelblum DY, et al. Safety of thoracic radiotherapy in patients with prior immune-related adverse events from immune checkpoint inhibitors. Ann Oncol. 2020;31(12):1719–24. https://doi.org/10.1016/j.annonc.2020.09.016.
Article
CAS
Google Scholar
Jung HA, Noh JM, Sun JM, Lee SH, Ahn JS, Ahn MJ, et al. Real world data of durvalumab consolidation after chemoradiotherapy in stage III non-small-cell lung cancer. Lung Cancer. 2020;146:23–9. https://doi.org/10.1016/j.lungcan.2020.05.035.
Article
Google Scholar
Hanania AN, Mainwaring W, Ghebre YT, Hanania NA, Ludwig M. Radiation-induced lung injury: assessment and management. Chest. 2019;156(1):150–62. https://doi.org/10.1016/j.chest.2019.03.033.
Article
Google Scholar
Delaunay M, Cadranel J, Lusque A, Meyer N, Gounant V, Moro-Sibilot D, et al. Immune-checkpoint inhibitors associated with interstitial lung disease in cancer patients. Eur Respir J. 2017:1–13. https://doi.org/10.1183/13993003.00050-2017.
Liang J, Li M, Sui Q, Hu Z, Bian Y, Huang Y, et al. Compare the efficacy and safety of programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L1) inhibitors for advanced non-small cell lung cancer: a Bayesian analysis. Transl Lung Cancer Res. 2020;9(4):1302–23. https://doi.org/10.21037/tlcr-20-192.
Article
CAS
Google Scholar
Nahm SH, Heywood R, Callaghan S, Serra-Bellver P, Gupta A, Cooksley T, et al. Patient and treatment characteristics of emergency presentations due to immune-mediated toxicities. Eur J Cancer. 2022;164:62–9. https://doi.org/10.1016/j.ejca.2021.12.033.
Article
CAS
Google Scholar
Cooksley T, Gupta A, Al-Sayed T, Lorigan P. Emergency presentations in patients treated with immune checkpoint inhibitors. Eur J Cancer. 2020;130:193–7. https://doi.org/10.1016/j.ejca.2020.02.025.
Article
CAS
Google Scholar