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  1. Integration of the viral genome into host cell chromatin is a pivotal and unique step in the replication cycle of retroviruses, including HIV. Inhibiting HIV replication by specifically blocking the viral inte...

    Authors: Peter K Quashie, Richard D Sloan and Mark A Wainberg
    Citation: BMC Medicine 2012 10:34
  2. We conducted a systematic review of evidence from randomized controlled trials to answer the following research question: What are the relative effects of different classes of antihypertensive drugs in reducin...

    Authors: Atle Fretheim, Jan Odgaard-Jensen, Odd Brørs, Steinar Madsen, Inger Njølstad, Ole F Norheim, Arne Svilaas, Ivar S Kristiansen, Hanne Thürmer and Signe Flottorp
    Citation: BMC Medicine 2012 10:33
  3. The management of viral hemorrhagic fevers (VHFs) has mainly focused on strict infection control measures, while standard clinical interventions that are provided to patients with other life-threatening condit...

    Authors: Giuseppe Ippolito, Heinz Feldmann, Simone Lanini, Francesco Vairo, Antonino Di Caro, Maria Rosaria Capobianchi and Emanuele Nicastri
    Citation: BMC Medicine 2012 10:31
  4. Whether healthy older people can benefit from cognitive training (CogTr) remains controversial. This study explored the benefits of CogTr in community dwelling, healthy, older adults and compared the effects o...

    Authors: Yan Cheng, Wenyuan Wu, Wei Feng, Jiaqi Wang, You Chen, Yuan Shen, Qingwei Li, Xu Zhang and Chunbo Li
    Citation: BMC Medicine 2012 10:30
  5. The decision in September 2011 in the UK to accept blood donations from non-practicing men who have sex with men (MSM) has received significant public attention. Will this rule change substantially boost the n...

    Authors: Halvard Bönig, Michael Schmidt, Kai Hourfar, Jörg Schüttrumpf and Erhard Seifried
    Citation: BMC Medicine 2012 10:29
  6. The epidermal growth factor receptor (EGFR) is a validated therapeutic target in non-small cell lung cancer (NSCLC). However, current single agent receptor targeting does not achieve a maximal therapeutic effe...

    Authors: Gang Chen, Peter Kronenberger, Erik Teugels, Ijeoma Adaku Umelo and Jacques De Grève
    Citation: BMC Medicine 2012 10:28

    The Correction to this article has been published in BMC Medicine 2020 18:29

  7. Early pregnancy loss (EPL) is a frustrating clinical problem, whose mechanisms are not completely understood. DNA methylation, which includes maintenance methylation and de novo methylation directed by DNA methyl...

    Authors: Li-Jun Yin, Yu Zhang, Ping-Ping Lv, Wei-Hua He, Yan-Ting Wu, Ai-Xia Liu, Guo-Lian Ding, Min-Yue Dong, Fan Qu, Chen-Ming Xu, Xiao-Ming Zhu and He-Feng Huang
    Citation: BMC Medicine 2012 10:26
  8. The poly (ADP-ribose) polymerase (PARP) family of enzymes plays a critical role in the maintenance of DNA integrity as part of the base excision pathway of DNA repair. PARP1 is overexpressed in a variety of ca...

    Authors: Shivaani Kummar, Alice Chen, Ralph E Parchment, Robert J Kinders, Jay Ji, Joseph E Tomaszewski and James H Doroshow
    Citation: BMC Medicine 2012 10:25
  9. Spinal muscular atrophy (SMA) is the leading genetic cause of infant death. It is caused by mutations/deletions of the survival motor neuron 1 (SMN1) gene and is typified by the loss of spinal cord motor neurons,...

    Authors: Melissa Bowerman, Lyndsay M Murray, Justin G Boyer, Carrie L Anderson and Rashmi Kothary
    Citation: BMC Medicine 2012 10:24
  10. Metastatic melanoma is the most aggressive form of skin cancer with a median overall survival of less than one year. Advancements in our understanding of how melanoma evades the immune system as well as the re...

    Authors: Laura Finn, Svetomir N Markovic and Richard W Joseph
    Citation: BMC Medicine 2012 10:23
  11. Clinical experience suggests that many patients with Modic changes have relatively severe and persistent low back pain (LBP), which typically appears to be resistant to treatment. Exercise therapy is the recom...

    Authors: Rikke K Jensen, Charlotte Leboeuf-Yde, Niels Wedderkopp, Joan S Sorensen and Claus Manniche
    Citation: BMC Medicine 2012 10:22
  12. Age-related macular degeneration (AMD) is a debilitating, common cause of visual impairment. While the last decade has seen great progress in understanding the pathophysiology of AMD, the molecular changes tha...

    Authors: S Scott Whitmore and Robert F Mullins
    Citation: BMC Medicine 2012 10:21
  13. Prosthetic joint infection is an uncommon but serious complication of hip replacement. There are two main surgical treatment options, with the choice largely based on the preference of the surgeon. Evidence is...

    Authors: Andrew D Beswick, Karen T Elvers, Alison J Smith, Rachael Gooberman-Hill, Andrew Lovering and Ashley W Blom
    Citation: BMC Medicine 2012 10:18
  14. There is an ongoing debate concerning the risk benefit ratio of psychopharmacologic compounds. With respect to the benefit, recent reports and meta-analyses note only small effect sizes with comparably high pl...

    Authors: Florian Seemüller, Hans-Jürgen Möller, Sandra Dittmann and Richard Musil
    Citation: BMC Medicine 2012 10:17
  15. Pneumonia is a leading cause of children's deaths in developing countries and hinders achievement of the fourth Millennium Development Goal. This goal aims to reduce the under-five mortality rate, by two third...

    Authors: Maheswari G Srinivasan, Grace Ndeezi, Cordelia Katureebe Mboijana, Sarah Kiguli, Gabriel S Bimenya, Victoria Nankabirwa and James K Tumwine
    Citation: BMC Medicine 2012 10:14
  16. A decade ago celiac disease was considered extremely rare outside Europe and, therefore, was almost completely ignored by health care professionals. In only 10 years, key milestones have moved celiac disease f...

    Authors: Anna Sapone, Julio C Bai, Carolina Ciacci, Jernej Dolinsek, Peter HR Green, Marios Hadjivassiliou, Katri Kaukinen, Kamran Rostami, David S Sanders, Michael Schumann, Reiner Ullrich, Danilo Villalta, Umberto Volta, Carlo Catassi and Alessio Fasano
    Citation: BMC Medicine 2012 10:13
  17. Shiga toxin-producing Escherichia coli (STEC) are the most virulent diarrheagenic E. coli known to date. They can be spread with alarming ease via food as exemplified by a large sprout-borne outbreak of STEC O104...

    Authors: Dirk Werber, Gérard Krause, Christina Frank, Angelika Fruth, Antje Flieger, Martin Mielke, Lars Schaade and Klaus Stark
    Citation: BMC Medicine 2012 10:11
  18. In a climate of economic uncertainty, cost effectiveness analysis is a potentially important tool for making choices about health care interventions. Methods for such analyses are well established, but the res...

    Authors: Suzanne R Hill
    Citation: BMC Medicine 2012 10:10
  19. Signal transducer and activator of transcription 3 (STAT3) is activated in majority of ovarian tumors and confers resistance to cisplatin treatment in patients with ovarian cancer. We have reported previously ...

    Authors: Prabodh K Kandala and Sanjay K Srivastava
    Citation: BMC Medicine 2012 10:9
  20. Iron deficiency without anemia is related to adverse symptoms that can be relieved by supplementation. Since a blood donation can induce such an iron deficiency, we investigated the clinical impact of iron tre...

    Authors: Sophie Waldvogel, Baptiste Pedrazzini, Paul Vaucher, Raphael Bize, Jacques Cornuz, Jean-Daniel Tissot and Bernard Favrat
    Citation: BMC Medicine 2012 10:8
  21. The hypothalamic-pituitary-adrenal axis is activated in response to stress. One of the activated hypothalamic hormones is arginine vasopressin, a hormone involved in hemodynamics and osmoregulation. Copeptin, ...

    Authors: Christian H Nickel, Roland Bingisser and Nils G Morgenthaler
    Citation: BMC Medicine 2012 10:7
  22. Febrile neutropenia is a frequently occurring and occasionally life-threatening complication of treatment for childhood cancer. Many biomarkers have been proposed as predictors of adverse events. We aimed to u...

    Authors: Robert S Phillips, Ros Wade, Thomas Lehrnbecher, Lesley A Stewart and Alex J Sutton
    Citation: BMC Medicine 2012 10:6
  23. Psychiatric nosology is widely criticized, but solutions are proving elusive. Planned revisions of diagnostic criteria will not resolve heterogeneity, comorbidity, fuzzy boundaries between normal and pathologi...

    Authors: Randolph M Nesse and Dan J Stein
    Citation: BMC Medicine 2012 10:5
  24. Inability to control autoimmunity is the primary barrier to developing a cure for type 1 diabetes (T1D). Evidence that human cord blood-derived multipotent stem cells (CB-SCs) can control autoimmune responses ...

    Authors: Yong Zhao, Zhaoshun Jiang, Tingbao Zhao, Mingliang Ye, Chengjin Hu, Zhaohui Yin, Heng Li, Ye Zhang, Yalin Diao, Yunxiang Li, Yingjian Chen, Xiaoming Sun, Mary Beth Fisk, Randal Skidgel, Mark Holterman, Bellur Prabhakar…
    Citation: BMC Medicine 2012 10:3
  25. Sepsis is the clinical syndrome derived from the host response to an infection and severe sepsis is the leading cause of death in critically ill patients. Several biomarkers have been tested for use in diagnos...

    Authors: Katia Donadello, Sabino Scolletta, Cecilia Covajes and Jean-Louis Vincent
    Citation: BMC Medicine 2012 10:2
  26. The Alvarado score can be used to stratify patients with symptoms of suspected appendicitis; the validity of the score in certain patient groups and at different cut points is still unclear. The aim of this st...

    Authors: Robert Ohle, Fran O'Reilly, Kirsty K O'Brien, Tom Fahey and Borislav D Dimitrov
    Citation: BMC Medicine 2011 9:139
  27. Mental disorders are associated with a considerable burden of disease as well as being risk factors for other health outcomes. The new Global Burden of Disease (GBD) Study will make estimates for both the disa...

    Authors: Amanda J Baxter, Fiona J Charlson, Adele J Somerville and Harvey A Whiteford
    Citation: BMC Medicine 2011 9:134
  28. About half of Americans 50 to 75 years old do not follow recommended colorectal cancer (CRC) screening guidelines, leaving 40 million individuals unscreened. A simple blood test would increase screening compli...

    Authors: Jorja D Warren, Wei Xiong, Ashley M Bunker, Cecily P Vaughn, Larissa V Furtado, William L Roberts, John C Fang, Wade S Samowitz and Karen A Heichman
    Citation: BMC Medicine 2011 9:133
  29. The validation of biomarkers has become a key goal of translational biomedical research. The purpose of this article is to discuss the role of biomarkers in the management of acute lung injury (ALI) and relate...

    Authors: Alastair G Proudfoot, Matthew Hind and Mark JD Griffiths
    Citation: BMC Medicine 2011 9:132
  30. Kawasaki disease is an acute vasculitis of infants and young children that is recognized through a constellation of clinical signs that can mimic other benign conditions of childhood. The etiology remains unkn...

    Authors: Xuefeng B Ling, Kenneth Lau, John T Kanegaye, Zheng Pan, Sihua Peng, Jun Ji, Gigi Liu, Yuichiro Sato, Tom TS Yu, John C Whitin, James Schilling, Jane C Burns and Harvey J Cohen
    Citation: BMC Medicine 2011 9:130
  31. Currently available pharmacological and non-pharmacological treatments have shown only modest effects in slowing the progression of dementia. Our objective was to assess the impact of a long-term non-pharmacol...

    Authors: Elmar Graessel, Renate Stemmer, Birgit Eichenseer, Sabine Pickel, Carolin Donath, Johannes Kornhuber and Katharina Luttenberger
    Citation: BMC Medicine 2011 9:129
  32. Effective strategies for the primary prevention of low back pain (LBP) remain elusive with few large-scale clinical trials investigating exercise and education approaches. The purpose of this trial was to dete...

    Authors: Steven Z George, John D Childs, Deydre S Teyhen, Samuel S Wu, Alison C Wright, Jessica L Dugan and Michael E Robinson
    Citation: BMC Medicine 2011 9:128