Comorbidity and dementia: a scoping review of the literature
BMC Medicine volume 12, Article number: 192 (2014)
Evidence suggests that amongst people with dementia there is a high prevalence of comorbid medical conditions and related complaints. The presence of dementia may complicate clinical care for other conditions and undermine a patient’s ability to manage a chronic condition. The aim of this study was to scope the extent, range and nature of research activity around dementia and comorbidity.
We undertook a scoping review including all types of research relating to the prevalence of comorbidities in people with dementia; current systems, structures and other issues relating to service organisation and delivery; patient and carer experiences; and the experiences and attitudes of service providers. We searched AMED, Cochrane Library, CINAHL, PubMed, NHS Evidence, Scopus, Google Scholar (searched 2012, Pubmed updated 2013), checked reference lists and performed citation searches on PubMed and Google Scholar (ongoing to February 2014).
We included 54 primary studies, eight reviews and three guidelines. Much of the available literature relates to the prevalence of comorbidities in people with dementia or issues around quality of care. Less is known about service organisation and delivery or the views and experiences of people with dementia and their family carers. There is some evidence that people with dementia did not have the same access to treatment and monitoring for conditions such as visual impairment and diabetes as those with similar comorbidities but without dementia.
The prevalence of comorbid conditions in people with dementia is high. Whilst current evidence suggests that people with dementia may have poorer access to services the reasons for this are not clear. There is a need for more research looking at the ways in which having dementia impacts on clinical care for other conditions and how the process of care and different services are adapting to the needs of people with dementia and comorbidity. People with dementia should be included in the debate about the management of comorbidities in older populations and there needs to be greater consideration given to including them in studies that focus on age-related healthcare issues.
World-wide there are an estimated 35.6 million people with dementia. By 2050 it has been estimated that this number will rise to more than 115 million . Dementia is primarily a disease of old age and it often coexists with other conditions of old age. Evidence suggests that amongst people with dementia there is a high prevalence of comorbid medical conditions and related complaints -. In addition, there is evidence to support an association between the dementia syndrome including Alzheimer’s disease and cardiovascular risk factors, such as hypertension and hypercholesterolaemia ,.
Comorbidity amongst people with dementia presents particular challenges for primary and secondary care. Certain comorbid medical conditions may exacerbate the progression of dementia . For example, cognitive decline may be accelerated in older people with type 2 diabetes ,. Moreover, the presence of dementia may adversely affect and complicate the clinical care of other conditions and be a key factor in how patients’ needs are anticipated and specialist and emergency services are used ,. It may also undermine patients’ abilities to self-manage chronic conditions and engage in health maintenance activities . Despite this, little is known about the effects of comorbidity on processes and quality of care, patient experience, or how services are adapting to address the particular needs of this population .
A review of qualitative research on the experience of diagnosis and treatment of dementia  found very little evidence relating to the experiences of people diagnosed with dementia who have an accompanying comorbid condition. There is also a lack of research on patients’ views on the ways in which multiple conditions affect their health, well-being and clinical care . The aim of this review was to identify the extent, range and nature of research activity relating to dementia and comorbidity, in particular the prevalence of co-morbidity amongst people with dementia, systems and structures that currently exist for the care of people with dementia who have comorbid medical conditions, and the experiences of people with dementia who have comorbid medical conditions and their family carers.
The scoping review was guided by Arksey and O’Malley’s methodological framework , which includes: identifying the research question; searching for relevant studies; selecting studies; charting the data and collating and summarising and reporting the results. This approach allowed us to incorporate a range of study designs and address questions beyond those related to treatment efficacy. Whilst the scoping review has a number of similarities to a systematic review it does not typically involve quality assessment and findings are reported in a narrative format ,. The inclusion criteria and methods for the review were pre-specified in a protocol . The protocol was externally peer reviewed as part of the National Institute for Health Research (NIHR) funding process.
Identifying the research question
We included studies involving people with dementia who had an additional comorbid health condition. Although we included all types of comorbidities there was a particular focus on three exemplar comorbid medical conditions; diabetes, stroke and visual impairment. These three conditions were chosen because they are common in older people, generally involve some form of external monitoring and require collaboration between primary and secondary care. Moreover, they may exacerbate or influence the progression of dementia and management of these conditions; in particular, self-management is likely to be complicated by the presence of dementia . We focused on community dwelling participants and excluded studies in long term care settings. We looked for studies relating to the prevalence of comorbidities in people with dementia or cognitive impairment; current systems, structures and other issues relating to service organisation and delivery; patient and carer experiences; and the experiences and attitudes of service providers. We included all study types including systematic reviews, randomised controlled trials (RCTs), controlled studies, observational studies and qualitative studies using any recognisable qualitative methodology. In addition, we included non-research items, such as clinical guidelines. We excluded studies disseminated in languages other than English.
Searching for relevant studies
We searched for a representative range of material which provided an overview of current knowledge and that identified some key examples of developments in the organisation and delivery of care for people with dementia and comorbid conditions. We included published and unpublished literature with no date restrictions. Studies were identified by computerised searches of AMED, Cochrane Library (including CENTRAL, CDSR, DARE, HTA), CINAHL (EBSCO Publishing) (1980 to 2012), PubMed (1950 to 2013), NHS Evidence (searched September 2012) and Scopus (1966 to 2012). The electronic search strategy was developed by an experienced information scientist with input from the project team. An example of the search query for PubMed is given in Table 1. In addition, we employed extensive lateral search techniques, such as checking reference lists, performing key word searches in Google Scholar and using the `cited by’ option in PubMed. We also contacted experts and those with an interest in dementia, such as the Alzheimer’s Society, the Thomas Pocklington Trust, Royal National Institute for the Blind, Diabetes UK, the Stroke Association, and the Dementia and Sight Loss Interest Group. Such lateral strategies have been shown to be particularly important for identifying non-randomised studies . The original electronic database searches were conducted in September 2012, with the PubMed search updated in November 2013 and lateral searches updated in February 2014.
Selecting studies and charting the data
Electronic search results were downloaded into EndNote bibliographic software and, where possible, duplicates deleted. Two authors (FB and AB) independently screened titles and abstracts identified by the electronic search and applied the selection criteria to potentially relevant papers. Data were extracted by one author using a standardised checklist and checked by a second. Any disagreements were resolved by consensus or by discussion with a third author (CG). Where results of a study were reported in more than one publication, we grouped reports together and marked the publication with the most complete data as the primary reference; the other papers describing the same study were classified as associated papers. Data extracted included type of item (for example, empirical study, review, guideline), aims/research questions, methods, study focus, participants, setting and relevant outcome data (for example, rates of comorbidities, access to treatment, patient and carer views).
Reporting the results
Studies were grouped into the following categories: 1) prevalence, 2) quality of care, 3) views and experiences (patients, carers and health care professionals) and 4) health service organisation and delivery. All data are reported in a narrative format.
Description of studies
We included 74 papers, 65 of which were classified as primary references ,,,,- and nine as associated papers -. Study characteristics are summarised in the list below and details of individual studies, including the links between primary and associated papers, in Additional file 1. An overview of the selection process can be seen in Figure 1. We included studies conducted in 12 different countries but 63% were from the UK and USA; the majority were observational, qualitative or reviews. Participants were predominantly community dwelling (some had mixed samples and included those living in long-term care) and the majority were older than 70; ethnicity was not reported in 55% (n =36) of studies. In 60% of studies (n =39) participants all had dementia, in 25% (n =16) they had mixed populations including people with dementia, cognitive impairment and delirium and in 15% (n =10) they had cognitive impairment. A total of 39 studies (60%) focused on a single comorbidity and the rest on more than one comorbidity or general comorbidity/multimorbidity (for example papers relating to the experiences of people with dementia in acute hospitals). We found more evidence relating to diabetes or visual impairment than relating to stroke, and most of the evidence related to the prevalence and quality of care with less on service organisation and delivery or views and experiences of patients, carers or health care professionals.
Overview of study characteristics
Study information a
Year of publication
Range 1989 to 2014
UK number = 23
USA number = 18
Europe (not UK) number = 8
Australia number = 3
Canada number = 4
Japan number = 2
International reviews/guidance number = 7
Type of study
Case control number = 9
Cohort study number = 12
Cross sectional number = 15
Guideline/policy document number = 3
Qualitative number = 7
RCT number = 3
Survey number = 3
Review/scoping number = 8
Other number = 5
Areas covered in study b
Prevalence number = 28
Service organisation and delivery number = 16
Views and experiences number = 12
Quality of care number = 21
Hospital/outpt clinic number = 30
Community number = 12
Primary care number = 7
Mixed community/residential care number = 5
Population based sample number = 8
Type of participants
Type of cognitive impairment
Dementia number = 40
Cognitive impairment (including dementia and delirium) number = 8
Mixed population including people with dementia and MCI number = 10
MCI = 9
Range 43 to 102 but majority over 70
Of 38 studies that gave a mean age - majority had mean age in 70s
Not specified number = 36
White (or majority white) number = 14
Mixed number = 3
Mixed but majority black number = 2
NA (for example, review) number = 10
Comorbidities included in studies b
Diabetes number = 15
Stroke number = 3
Visual impairment number = 14
Other comorbidities number = 7 (for example, cancer, MI)
General comorbidity number = 12
More than one comorbidity (but includes one of our target conditions) number = 14
Type of dementia
Alzheimers number = 8
Mixture of different types number = 4
Not reported in rest
Our main aim was to look at the prevalence of comorbidity (in particular stroke, diabetes and visual impairment) in people with dementia. Thirteen studies provided data about the prevalence of comorbidities in people with dementia ,,,,,,,,,,- and two the prevalence of comorbidities in people with mild cognitive impairment (MCI) , (see Table 2). The representativeness of the samples varied. Four studies included population based samples ,,,, six recruited populations from primary care databases ,,,,, and five used samples from hospitals or out-patient clinics ,,,, [see Additional file 2]. Data were collected from medical records in six studies ,,,,,, from clinical examination or interviews in six ,,,,, and from a mixture of medical records and clinical examination in three ,,. The presence of dementia and comorbid medical conditions was assessed using a variety of measures [see Additional file 3].
We also included a further eight studies that reported the prevalence of dementia in people with one of our three target comorbidities ,,,,,,, (see Table 3). Three studies included samples from out-patient clinics ,,, one data from an RCT in primary care , two research administration or health claims databases in the USA  and Australia , one from a stroke register in Canada  and one a population derived community-based sample in Australia . Three collected data from medical or database records ,, and the rest from face to face interviews or clinical examinations.
Prevalence of target comorbidities in people with dementia
Twelve studies reported the prevalence of diabetes in populations of people with dementia ,,,,,,,,, or MCI ,. Prevalence rates varied from 6% to 39%. The two largest studies which both involved participants from national primary care data sets in the UK, one from Scotland  and one from the UK (primarily England) , reported similar prevalence rates of 13%  (personal communication B Guthrie) and 14% . Five studies compared rates of diabetes in those with and without dementia. Of those, three studies with samples recruited from primary care databases, two from the USA and one from the UK, found similar rates between groups ,, and a study in hospital inpatients in Switzerland found no significant differences in rates of diabetes mellitus between those with and without dementia . In contrast, a study of hospital in-patients in the UK found significantly fewer people with dementia diagnosed with type-2 dementia than controls without dementia .
Nine studies reported the prevalence of stroke in people with dementia ,,,,,,,, and two in people with cognitive impairment ,. Prevalence rates varied from 3% in hospitalised older people in the UK  to 34% in a sample of urban and rural community dwelling people with cognitive impairment in the USA . Two studies used records from large primary care databases in the UK, one reported that rates of stroke in people with dementia were 19%  and the other that rates of cerebrovascular disease (including stroke) were 29% . Five studies compared rates of stroke in people with and without dementia. Three found no significant difference in the prevalence of stroke ,,, but one study of hospital inpatients found that stroke was more common in people with dementia  and a primary care based study in the UK found a greater prevalence of cerebrovascular disease in people with dementia .
Four studies reported the prevalence of some form of visual impairment in people with dementia, including all eye diseases , glaucoma , and cataracts ,. Differences in the populations studied and the way cases were identified make comparisons across studies difficult. Two studies compared rates of glaucoma in people with dementia and those without; prevalence in people with dementia was lower in a population sample in Finland  but not different in hospital inpatients in a retrospective case control study in the UK . Two studies compared rates of cataracts. A large primary care cohort study in the UK found a lower incidence rate for cataracts in people with AD than controls  but a smaller population-based study in Finland reported no difference in the rates of cataracts .
Prevalence of dementia in people with stroke, diabetes and visual impairment
Five studies looked at the prevalence of dementia or cognitive impairment in populations of people with diabetes. In a large population-based study in the USA, 13% of people with diabetes had dementia or cognitive impairment  compared with 23% in a sample recruited through primary care in the UK . Two studies reported the prevalence of dementia in people with visual impairment recruited via eye clinics. In one  19% of people with macular disease had dementia and in the other  20% of people with glaucoma had memory impairment and 22% impaired executive functioning. One study looked at the prevalence of dementia amongst people who had had a stroke. Of more than 10,000 people on a stroke register 9% were reported to have dementia.
Quality of care
We categorised 23 studies as relating to quality of care in some way, 11 of which compared access to treatment or receipt of services in groups with and without dementia. Ten of the 11 studies found some evidence that people with dementia were less likely to receive the same quality of care or access to services compared to those without dementia. For example, studies found that people with dementia were less likely to receive monitoring for diabetes related problems , and had reduced access to treatment, such as intravenous thrombolysis for stroke , surgery for cataracts , treatment for age-related macular degeneration (AMD) , or services for diabetes ,. More details can be seen in Table 4. A German study reported that older people with a greater number of comorbidities were less likely to receive cholinesterase inhibitors for dementia  and a Canadian study found evidence that pain is undertreated in people with dementia and arthritis .
In addition, there was evidence that having dementia or cognitive impairment impacts on a person’s ability to undertake self-care management. For example, people with dementia and diabetes had problems understanding their condition, managing medication and monitoring their blood glucose ,,,,.
Views and experiences
We included 11 studies looking at views and experiences of people with dementia, their family carers and health care professionals. Six were qualitative ,,,,, one was a mixed study including a review and qualitative study , two were reviews , and two were questionnaire studies ,. Three studies focused on people with dementia and diabetes ,,, two visual impairment ,, one deafness , one cancer  and four on the needs of people with dementia in general hospitals ,,,.
Literature on the experiences of older people with dementia in acute general hospitals has highlighted shortcomings in the care provided, attitudes and training of staff, the physical environment and problems with care cultures ,,. Poor communication is a major barrier to the provision of good care for people with dementia and a comorbid health condition ,,. Practitioners reported that they found it difficult to communicate with people with dementia and communication difficulties are compounded when they have additional comorbidities which make communication difficult, such as hearing loss or sight loss ,,. There were also problems with communication between different professionals and specialist teams with a lack of coordinated working between practitioners in different specialities . A lack of appropriate knowledge and training was also a major barrier, with those working in acute care hospitals , palliative care  and diabetes  lacking knowledge about dementia. Conversely, those in dementia services may lack awareness about how to support people with dementia and visual impairment ,.
A qualitative study involving the views of 21 caregivers of people with dementia and type 2 diabetes found that behavioural and psychological symptoms of dementia disrupted diabetes care. In addition, carers felt that they received inadequate support in planning their relatives care, that their contribution to managing their relatives care was not always recognised and that they were often excluded from decision making .
Service organisation and delivery
Guidelines and care pathways
Guidance on the care of older people with diabetes highlights the need to balance the benefits of diabetes treatment while minimising the risk in people with dementia  as this group may be at increased risk of hypoglycaemia , and guidance from the College of Optometrists states that when examining patients with dementia optometrists have a duty to carry out whatever tests are necessary to determine the patients’ need for vision care . However, most guidelines are condition specific and generally fail to take into account multimorbidity or the needs of people with dementia ,,,,,.
A recent review identified 16 guidelines/position statements or standards (from the UK, USA and Australia) for the care of people with dementia but these generally focused on standards for providing optimal care for older people with cognitive impairment in acute hospitals or specific issues, such as hydration, nutrition or wandering . They did not cover issues relating to the care of people with dementia and specific medical conditions (such as diabetes). Moreover, most models of practice for work with people with dementia do not mention visual impairment .
Models of care for older people with cognitive impairment
A number of initiatives have been developed to improve the care of older people with dementia in acute hospitals, including liaison psychiatric services , or specialist units that combine medical and mental health care for older people ,. Much of the work in this area is descriptive  although a specialist medical and mental health unit for people with dementia has recently been evaluated in an RCT . They found no difference between the specialist unit and standard care on general medical wards for their primary outcome (days spent at home) but there were significant differences in process items in favour of the intervention, and family carers were more satisfied . However, the study excluded patients with clinical needs for specialist services, such as surgery or stroke units.
A scoping review of interventions for cognitively impaired older people in emergency departments found no evaluations of organisational or system level interventions and little evidence of appropriate interventions . We found no evaluations of interventions aimed specifically at our three target comorbidities, although a retrospective analysis of stroke patients suggested that cognitively impaired patients benefit from admission to an acute rehabilitation stroke unit .
We included 54 primary studies, eight reviews and two guidelines that addressed issues around dementia and comorbidity. We found evidence of a lack of continuity in health care systems and structures for people with dementia and comorbidity, with little integration or communication between different teams and specialities . Moreover, many models of care are focused on single diseases and do not take into account the needs of those with multimorbidity , or of their family carers. We found a number of studies reporting prevalence for our three target comorbidities. Whilst heterogeneity in the populations and differences in the way that conditions were ascertained make comparisons across studies difficult the data do suggest that rates of diabetes in people with dementia may be between 13 and 20 percent and of stroke between 16 and 29 percent.
We undertook a scoping review rather than a systematic review. A limitation of such an approach is that the review does not include an assessment of the quality of the included studies or evaluate the effectiveness of interventions. However, evaluative research in this area is limited and our aim was to examine the extent, range and nature of research activity around patient and carer need, health care provision and service organisation for people with dementia and comorbidity. Moreover, whilst we did not undertake formal quality assessment we did extract methodological information on study populations and data collection methods that aided in the interpretation of the evidence. We set out to include a representative rather than exhaustive range of literature and it is possible that we have missed relevant studies or guidelines. However, our search strategy was guided by systematic review methodology and we employed extensive database and lateral searches. We are confident, therefore, that this scoping review provides a comprehensive summary of current evidence relating to dementia and comorbidity for people living in the community, particularly in relation to diabetes, stroke and visual impairment. We did, however, exclude studies in care homes where there are likely to be considerable levels of dementia and comorbidity. Moreover, the majority of our studies focus on single comorbidities and the review does not cover the presence of multiple conditions. The support that people with dementia and multiple health conditions need may be different than those with less complex needs. Further studies are needed to understand the complexity within multiple comorbidities.
To our knowledge, this is the first review of research and practice on co-morbidity in dementia. Most research on multimorbidity has been concerned with its effect on physical functioning and its measurement, with little research investigating the effect on processes of care or what constitutes `best care’ for these patients . Moreover, qualitative research on dementia has tended to focus on the experience of living with dementia as a single disease . This review sets out current research and knowledge about the impact of comorbidities on people diagnosed with dementia and what is known about their experiences of health care.
This review suggests that significant numbers of people with dementia have a comorbid health condition, such as diabetes or stroke. This has serious implications for the way that specialist services for conditions such as diabetes are delivered for people with dementia. Despite these high levels of comorbidity in people with dementia there was evidence that they did not have the same access to treatment and monitoring for conditions such as visual impairment and diabetes as those with similar comorbidities but without dementia. There may be a variety of factors that contribute to this finding. For example, people with dementia may be less likely to attend regular appointments or to notice or report relevant symptoms and they may be more reliant on carers to manage and facilitate appointments . It is also possible that clinicians may be more reluctant to investigate and treat patients with dementia either because of the difficulties involved in securing patient cooperation or because treatments are considered inappropriate for older patients with multimorbidity. In addition, if the dementia is symptomatic (such as the behavioural and psychological symptoms associated with dementia) then dementia may become clinically dominant and detract from the management of conditions such as diabetes mellitus ,.
Much of the available literature relates to the prevalence of comorbidities in people with dementia or issues around quality of care. There is less evidence relating to service organisation and delivery, patient and carer preferences or the decision making processes of clinicians involved in their care. Whilst there is literature relating to models of care for older people with cognitive impairment, this is focused on in-patient care for patients who would otherwise be admitted to a general medical ward and does not provide guidance on the management of specific conditions (such as diabetes or stroke) in people with dementia. In addition there is little guidance on the care of people with dementia and long-term conditions living in the community. Family caregivers of people who have dementia and other health conditions face great challenges in managing both conditions and dealing with the impact of accompanying behavioural and psychological symptoms of dementia on care routines . Despite this, little is known about how family carers can best be supported, or how health care services should adapt to address the particular needs of this population.
Recommendations for research
The review highlights significant gaps in the evidence. There is currently a lack of research on the experiences of patients and their family carers on living with dementia and comorbid conditions. Even less is known about healthcare providers experiences of managing people living with dementia and comorbid health conditions and how the presence of dementia influences the care they receive for their comorbidity. These are areas that are currently being explored in an NIHR study on dementia and comorbidity . In addition, there is a need for more detailed epidemiological work on the prevalence of comorbidities in people with dementia and the appropriateness of treatment and referral for this group. People with dementia should be included in debate about the management of comorbidities in older populations, and there needs to be greater consideration given to including them in studies and trials that focus on age-related healthcare issues. Equally, dementia-specific studies need to consider the impact of comorbidities on the experience of living and dying with dementia.
The prevalence of comorbid conditions in people with dementia is high. Whilst current evidence suggests that people with dementia may have poorer access to services the reasons for this are not clear. There is a need for more research looking at the ways in which having dementia impacts on clinical care for other conditions, how process of care and different services can adapt to the needs of people with dementia and comorbidity, and what interventions might improve access to services and the physical health of people with dementia. Clinical guidance should consider the particular needs of those with dementia and comorbid health conditions.
aAll numbers refer to the numbers of studies not individual participants.
bsome studies classified in more than one category.
FB wrote the protocol, undertook data extraction, quality assessment and analysis and wrote the paper. AMB undertook data extraction, quality assessment and analysis and helped to write the paper. CG participated in study design, interpretation of the results and helped to revise the paper. GR participated in study design, interpretation of the results and helped to revise the paper. CB participated in study design, interpretation of the results and critical review of the paper. LR participated in study design, interpretation of the results and critical review of the paper. SN participated in the design of the study and advised on interpretation of the prevalence data. JS participated in study design, interpretation of the results and critical review of the paper. FB confirms that the manuscript is an honest, accurate, and transparent account of the study being reported, that no important aspects of the study have been omitted, and that any discrepancies from the review as planned have been explained. All authors read and approved the final manuscript.
age-related macular degeneration
Allied and Complementary Medicine Database
Cochrane Central Register of Controlled Trials
Cochrane Database of Systematic Reviews
Database of Abstracts of Reviews of Effectiveness
health technology assessment
mild cognitive impairment
randomised controlled trial
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We would like to thank Reinhard Wentz who helped design and run the database searches and Professor Bruce Guthrie for providing us with additional unpublished data.
This article presents independent research commissioned by the National Institute for Health Research (NIHR) under HS & DR (Grant Reference Number 11/1017/07). The views expressed in this paper are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. The sponsor of the study had no role in study design, data analysis, data interpretation or writing of the report.
The authors declare that they have no competing interests.
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Bunn, F., Burn, AM., Goodman, C. et al. Comorbidity and dementia: a scoping review of the literature. BMC Med 12, 192 (2014). https://doi.org/10.1186/s12916-014-0192-4