- Erratum
- Open Access
Erratum: Accuracy of microRNAs as markers for the detection of neck lymph node metastases in patients with head and neck squamous cell carcinoma
- Received: 18 June 2015
- Accepted: 18 June 2015
- Published: 1 July 2015
The original article was published in BMC Medicine 2015 13:108
Author´s correction note
Upon reviewing our recently published research article [1], we noticed that some of the data presented in the manuscript and on the tables were incorrectly presented. These mistakes do not change the overall conclusions regarding the high accuracy of miR-203 and miR-205 as diagnostic markers of neck metastases in HNSCC.
Corrected text
1. (Page 8: End of “Validation and diagnostic accuracy of miR-203 and miR-205 expression in FNA samples”)
Please replace
Sensitivity and specificity values of microRNAs evaluated in discriminating metastatic and non-metastatic lymph nodes in FFPE and FNA biopsies from lymph node samples
microRNA | Sensitivity | Specificity | ||||
---|---|---|---|---|---|---|
Cutoffa | Metastaticb | Macrometastases | Micrometastases | Isolated tumor cells | Non-metastatic | |
% (95 % CI) (n) | % (95 % CI) (n) | % (95 % CI) (n) | % (95 % CI) (n) | % (95 % CI) (n) | ||
FFPE samples | ||||||
miR-200a | 5.96 | 76.0 (54.5-89.8) (19/25) | 94.4 (70.6-99.7) (17/18) | 40.0 (7.3-82.9) (2/5) | 0 (0–80.2) (0/2) | 100 (71.7-100) (13/13) |
miR-200c | 2.33 | 88.0 (67.7-96.8) (22/25) | 100 (78.1-100) (17/18) | 80.0 (29.9-98.9) (4/5) | 0 (0–80.2) (0/2) | 100 (71.7-100)) (13/13) |
miR-203 | 1.96 | 100 (83.4-100) (25/25) | 100 (78.1-100) (17/18) | 100 (46.3-100) (5/5) | 100 (19.8-100) (2/2) | 100 (71.7-100) (13/13) |
miR-205 | 1.54 | 100 (83.4-100) (25/25) | 100 (78.1-100) (17/18) | 100 (46.3-100) (5/5) | 100 (19.8-100) (2/2) | 100 (71.7-100) (13/13) |
FNA samples classified by cytology | ||||||
miR-203 | 10 | 100 (91.5-100) (42/42) | 100 (91.5-100) (42/42) | N/A | N/A | 100 (94.9-100) (71/71) |
miR-205 | 10 | 100 (91.5-100) (42/42) | 100 (91.5-100) (42/42) | N/A | N/A | 100 (94.9-100) (71/71) |
FNA samples classified by histology | ||||||
miR-203 | 10 | 92.9 (80.5-98.4) (68/71) | 100 (89.3-100) (68/68) | 0 (0) (0/2) | 0 (0) (0/1) | 100 (94.9-100) (71/71) |
miR-205 | 10 | 92.9 (80.5-98.4) (68/71) | 100 (89.3-100) (68/68) | 0 (0) (0/2) | 0 (0) (0/1) | 100 (94.9-100) (71/71) |
With the amended text
Sensitivity and specificity values of microRNAs evaluated in discriminating metastatic and non-metastatic lymph nodes in FFPE and FNA biopsies from lymph node samples
microRNA | Sensitivity | Specificity | ||||
---|---|---|---|---|---|---|
Cutoffa | Metastaticb | Macrometastases | Micrometastases | Isolated tumor cells | Non-metastatic | |
% (95 % CI) (n) | % (95 % CI) (n) | % (95 % CI) (n) | % (95 % CI) (n) | % (95 % CI) (n) | ||
FFPE samples | ||||||
miR-200a | 5.96 | 76.0 (54.5-89.8) (19/25) | 94.4 (70.6-99.7) (17/18) | 40.0 (7.3-82.9) (2/5) | 0 (0–80.2) (0/2) | 100 (71.7-100) (13/13) |
miR-200c | 2.33 | 88.0 (67.7-96.8) (22/25) | 100 (78.1-100) (18/18) | 80.0 (29.9-98.9) (4/5) | 0 (0–80.2) (0/2) | 100 (71.7-100)) (13/13) |
miR-203 | 1.96 | 100 (83.4-100) (25/25) | 100 (78.1-100) (18/18) | 100 (46.3-100) (5/5) | 100 (19.8-100) (2/2) | 100 (71.7-100) (13/13) |
miR-205 | 1.54 | 100 (83.4-100) (25/25) | 100 (78.1-100) (18/18) | 100 (46.3-100) (5/5) | 100 (19.8-100) (2/2) | 100 (71.7-100) (13/13) |
FNA samples classified by cytology | ||||||
miR-203 | 10 | 100 (91.5-100) (42/42) | 100 (91.5-100) (42/42) | N/A | N/A | 100 (94.9-100) (71/71) |
miR-205 | 10 | 100 (91.5-100) (42/42) | 100 (91.5-100) (42/42) | N/A | N/A | 100 (94.9-100) (71/71) |
FNA samples classified by histology | ||||||
miR-203 | 10 | 93.3 (81.7-98.6) (42/45) | 100 (91.5-100) (42/42) | 0 (0) (0/2) | 0 (0) (0/1) | 100 (94.7-100) (68/68) |
miR-205 | 10 | 93.3 (81.7-98.6) (42/45) | 100 (91.5-100) (42/42) | 0 (0) (0/2) | 0 (0) (0/1) | 100 (94.7-100) (68/68) |
2. (Page 8: End of “Validation and diagnostic accuracy of miR-203 and miR-205 expression in FNA samples”)
Please replace
Accuracy characteristics of microRNAs in discriminating metastatic and non-metastatic lymph nodes in FFPE and FNA biopsies from lymph node samples
microRNA | PPV | NPV | Accuracy | AUC (95 % CI) |
---|---|---|---|---|
% (95 % CI) | % (95 % CI) | % (95 % CI) | ||
FFPE samples | ||||
miR-200a | 100 (82.2-100.0) | 68.4 (43.5-87.3) | 84.2 (68.1-93.4) | 0.92 (0.83-0.99) |
miR-200c | 100 (84.4-100.0) | 81.2 (54.34-95.73) | 92.1 (77.5-97.9) | 0.94 (0.85-1.0) |
miR-203 | 100 (86.2-100) | 100 (75.1-100) | 100 (88.6-100) | 1.0 (0–1.0) |
miR-205 | 100 (86.2-100) | 100 (75.1-100) | 100 (88.6-100) | 1.0 (0–1.0) |
FNA samples classified by cytology | ||||
miR-203 | 100 (91.5-100) | 100 (94.9-100) | 100 (96.05-100) | 1.0 (0–1.0) |
miR-205 | 100 (91.5-100) | 100 (94.9-100) | 100 (96.05-100) | 1.0 (0–1.0) |
FNA samples classified by histology | ||||
miR-203 | 100 (90.9-100) | 95.9 (88.6-99.1) | 97.3 (92.1-99.4) | 0.963 (0.921-1.0) |
miR-205 | 100 (93.2-100) | 94.6 (85.1-98.8) | 96.7 (93.1-100) | 0.966 (0.921-1.0) |
With the amended text
Accuracy characteristics of microRNAs in discriminating metastatic and non-metastatic lymph nodes in FFPE and FNA biopsies from lymph node samples
microRNA | PPV | NPV | Accuracy | AUC (95 % CI) |
---|---|---|---|---|
% (95 % CI) | % (95 % CI) | % (95 % CI) | ||
FFPE samples | ||||
miR-200a | 100 (82.2-100.0) | 68.4 (43.5-87.3) | 84.2 (68.1-93.4) | 0.92 (0.83-0.99) |
miR-200c | 100 (84.4-100.0) | 81.2 (54.34-95.73) | 92.1 (77.5-97.9) | 0.94 (0.85-1.0) |
miR-203 | 100 (86.2-100) | 100 (75.1-100) | 100 (88.6-100) | 1.0 (0–1.0) |
miR-205 | 100 (86.2-100) | 100 (75.1-100) | 100 (88.6-100) | 1.0 (0–1.0) |
FNA samples classified by cytology | ||||
miR-203 | 100 (91.5-100) | 100 (94.9-100) | 100 (96.05-100) | 1.0 (0–1.0) |
miR-205 | 100 (91.5-100) | 100 (94.9-100) | 100 (96.05-100) | 1.0 (0–1.0) |
FNA samples classified by histology | ||||
miR-203 | 100 (91.5-100) | 95.9 (88.6-99.1) | 97.3 (92.1-99.4) | 0.963 (0.921-1.0) |
miR-205 | 100 (91.5-100) | 95.9 (88.6-99.1) | 97.3 (92.1-99.4) | 0.966 (0.921-1.0) |
Notes
Authors’ Affiliations
Reference
- de Carvalho AC, Scapulatempo-Neto C, Maia DC, Evangelista AF, Morini MA, Carvalho AL, et al. Accuracy of microRNAs as markers for the detection of neck lymph node metastases in patients with head and neck squamous cell carcinoma. BMC Med. 2015;13(1):108. doi:10.1186/s12916-015-0350-3.View ArticlePubMedPubMed CentralGoogle Scholar
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