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Erratum: Accuracy of microRNAs as markers for the detection of neck lymph node metastases in patients with head and neck squamous cell carcinoma

BMC Medicine volume 13, Article number: 155 (2015) Cite this article

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The original article was published in BMC Medicine 2015 13:108

Author´s correction note

Upon reviewing our recently published research article [1], we noticed that some of the data presented in the manuscript and on the tables were incorrectly presented. These mistakes do not change the overall conclusions regarding the high accuracy of miR-203 and miR-205 as diagnostic markers of neck metastases in HNSCC.

Corrected text

1. (Page 8: End of “Validation and diagnostic accuracy of miR-203 and miR-205 expression in FNA samples”)

Please replace

All in all, the sensitivity rate for both markers was 92.9 % (39/42, CI 95 %, 80.5–98.4), with a specificity level of 100 % (71/71, CI 95 %, 94.9–100) (Table 2; Figure 6B).

Table 2 Sensitivity and specificity values of microRNAs evaluated in discriminating metastatic and non-metastatic lymph nodes in FFPE and FNA biopsies from lymph node samples
Full size table

With the amended text

All in all, the sensitivity rate for both markers was 93.3 % (42/45, CI 95 %, 81.7–98.6), with a specificity level of 100 % (68/68, CI 95 %, 94.7–100) (Table 2; Figure 6B).

Table 2 Sensitivity and specificity values of microRNAs evaluated in discriminating metastatic and non-metastatic lymph nodes in FFPE and FNA biopsies from lymph node samples
Full size table

2. (Page 8: End of “Validation and diagnostic accuracy of miR-203 and miR-205 expression in FNA samples”)

Please replace

Moreover, negative predictive values were of 95.9 % (95 % CI, 88.6–99.1 %) and positive predictive values of 100 % (95 % CI, 90.9–100 %) for both microRNAs (Table 3).

Table 3 Accuracy characteristics of microRNAs in discriminating metastatic and non-metastatic lymph nodes in FFPE and FNA biopsies from lymph node samples
Full size table

With the amended text

Moreover, negative predictive values were of 95.9 % (95 % CI, 88.6–99.1 %) and positive predictive values of 100% (95 % CI, 91.5–100 %) for both microRNAs (Table 3).

Table 3 Accuracy characteristics of microRNAs in discriminating metastatic and non-metastatic lymph nodes in FFPE and FNA biopsies from lymph node samples
Full size table

Reference

  1. 1.

    de Carvalho AC, Scapulatempo-Neto C, Maia DC, Evangelista AF, Morini MA, Carvalho AL, et al. Accuracy of microRNAs as markers for the detection of neck lymph node metastases in patients with head and neck squamous cell carcinoma. BMC Med. 2015;13(1):108. doi:10.1186/s12916-015-0350-3.

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Affiliations

  1. Laboratory of Cancer Molecular Biology, Department of Biological Sciences, Federal University of São Paulo, Diadema, Brazil

    • Ana Carolina de Carvalho
    •  & Danielle Calheiros Campelo Maia

  2. Department of Pathology, Barretos Cancer Hospital, Barretos, Brazil

    • Cristovam Scapulatempo-Neto
    •  & Mariana Andozia Morini

  3. Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil

    • Ana Carolina de Carvalho
    •  & Adriane Feijó Evangelista

  4. Department of Head and Neck Surgery, Barretos Cancer Hospital, Barretos, Brazil

    • André Lopes Carvalho

  5. Laboratory of Cancer Molecular Biology, Department of Biological Sciences, Federal University of São Paulo, Diadema, Brazil

    • André Luiz Vettore

  6. Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore, Singapore

    • André Luiz Vettore

  7. Departamento de Cirurgia de Cabeça e Pescoço, Hospital de Câncer de Barretos, Rua Antenor Duarte Villela, 1331, Barretos, SP, 14784-400, Brazil

    • André Lopes Carvalho

  8. Laboratório de Biologia Molecular do Câncer, UNIFESP, Rua Pedro de Toledo, 669 - 11° andar, L11B, São Paulo, SP, 04039-032, Brazil

    • André Luiz Vettore

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Corresponding authors

Correspondence to André Lopes Carvalho or André Luiz Vettore.

Additional information

The online version of the original article can be found under doi:10.1186/s12916-015-0350-3.

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de Carvalho, A.C., Scapulatempo-Neto, C., Maia, D.C.C. et al. Erratum: Accuracy of microRNAs as markers for the detection of neck lymph node metastases in patients with head and neck squamous cell carcinoma. BMC Med 13, 155 (2015) doi:10.1186/s12916-015-0406-4

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