Post-stroke dementia – a comprehensive review
- Milija D. Mijajlović1Email author,
- Aleksandra Pavlović1,
- Michael Brainin2,
- Wolf-Dieter Heiss3,
- Terence J. Quinn4,
- Hege B. Ihle-Hansen5,
- Dirk M. Hermann6,
- Einor Ben Assayag7, 8,
- Edo Richard9,
- Alexander Thiel10,
- Efrat Kliper7, 8,
- Yong-Il Shin11,
- Yun-Hee Kim12,
- SeongHye Choi13,
- San Jung14,
- Yeong-Bae Lee15,
- Osman Sinanović16,
- Deborah A. Levine17,
- Ilana Schlesinger18, 19,
- Gillian Mead20,
- Vuk Milošević21,
- Didier Leys22,
- Guri Hagberg5,
- Marie Helene Ursin5,
- Yvonne Teuschl2,
- Semyon Prokopenko23,
- Elena Mozheyko23,
- Anna Bezdenezhnykh23,
- Karl Matz2,
- Vuk Aleksić24,
- DafinFior Muresanu25,
- Amos D. Korczyn26 and
- Natan M. Bornstein7, 8
© The Author(s). 2017
Received: 13 September 2016
Accepted: 3 January 2017
Published: 18 January 2017
Post-stroke dementia (PSD) or post-stroke cognitive impairment (PSCI) may affect up to one third of stroke survivors. Various definitions of PSCI and PSD have been described. We propose PSD as a label for any dementia following stroke in temporal relation. Various tools are available to screen and assess cognition, with few PSD-specific instruments. Choice will depend on purpose of assessment, with differing instruments needed for brief screening (e.g., Montreal Cognitive Assessment) or diagnostic formulation (e.g., NINDS VCI battery). A comprehensive evaluation should include assessment of pre-stroke cognition (e.g., using Informant Questionnaire for Cognitive Decline in the Elderly), mood (e.g., using Hospital Anxiety and Depression Scale), and functional consequences of cognitive impairments (e.g., using modified Rankin Scale). A large number of biomarkers for PSD, including indicators for genetic polymorphisms, biomarkers in the cerebrospinal fluid and in the serum, inflammatory mediators, and peripheral microRNA profiles have been proposed. Currently, no specific biomarkers have been proven to robustly discriminate vulnerable patients (‘at risk brains’) from those with better prognosis or to discriminate Alzheimer’s disease dementia from PSD. Further, neuroimaging is an important diagnostic tool in PSD. The role of computerized tomography is limited to demonstrating type and location of the underlying primary lesion and indicating atrophy and severe white matter changes. Magnetic resonance imaging is the key neuroimaging modality and has high sensitivity and specificity for detecting pathological changes, including small vessel disease. Advanced multi-modal imaging includes diffusion tensor imaging for fiber tracking, by which changes in networks can be detected. Quantitative imaging of cerebral blood flow and metabolism by positron emission tomography can differentiate between vascular dementia and degenerative dementia and show the interaction between vascular and metabolic changes. Additionally, inflammatory changes after ischemia in the brain can be detected, which may play a role together with amyloid deposition in the development of PSD. Prevention of PSD can be achieved by prevention of stroke. As treatment strategies to inhibit the development and mitigate the course of PSD, lowering of blood pressure, statins, neuroprotective drugs, and anti-inflammatory agents have all been studied without convincing evidence of efficacy. Lifestyle interventions, physical activity, and cognitive training have been recently tested, but large controlled trials are still missing.
KeywordsCognitive impairment Dementia Definitions and classification Diagnosis Neuroimaging Interventions Biomarkers Stroke
Stroke is a leading cause of disability . Research and interventions have historically focused on physical disabilities , while cognitive impairment – an important aspect for stroke survivors – has been rather neglected [3, 4]. Even minor stroke affects daily functioning, executive functions, and cognition, consequently affecting participation, quality of life, and return to work . Stroke survivors are at increased risk of developing cognitive impairment. Obviously, the acute tissue damage may affect cognition. Nevertheless, despite prospective data being available, results are conflicting and the direct cognitive effect of a stroke event beyond the cognitive decline associated with age and vascular risk factors remains poorly understood. Physical impairments tend to improve, to a greater or lesser degree, following stroke; however, for reasons which remain unknown, cognitive impairments progressively worsen.
This review paper is based on the proceedings of the International Congress on Vascular Dementia, Ljubljana, 2015, at which reviews of the literature on post-stroke cognitive impairment (PSCI) and post-stroke dementia (PSD) were presented by leaders of the field and discussed by a broad audience. Key thematic areas were chosen for further elucidation in smaller working groups and, after further discussions, a final review was compiled.
Methods of research
Using a focused search of PubMed/Medline from January 1995 until August 2016, the relevant literature on PSCI/PSD was critically reviewed. The following keywords were employed in te search: “cognitive impairment”, “dementia”, “definitions and classification”, “diagnosis”, “neuroimaging”, “interventions”, “biomarkers”, and “stroke”. References from the selected papers published in the English language were evaluated and included if they were found to be relevant to the focus of this systematic review. Experts were divided in four groups. The first group of experts conducted research about basic concepts, definitions, and epidemiology of PSD following stroke as well as on tools for assessment of cognitive impairment. The second group evaluated biomarkers for PSD, whereas as neuroimaging studies and interventions for PSD prevention and treatment were critically reviewed by the third and fourth groups, respectively.
A variety of classifications, diagnostic criteria, and descriptive syndromes are used to define PSCI , but a widely accepted and harmonized terminology is still missing . Post-stroke neuropsychological syndromes overlap – PSCI is responsible for a substantial number of vascular cognitive impairment (VCI) syndromes; PSCI includes the subgroups of PSD and PSCI not fulfilling criteria for dementia.
The direct application of established diagnostic criteria for dementia may not be suited to stroke populations. For example, the differentiation of dementia from PSD and PSCI not fulfilling criteria for dementia is usually based on limitations in activities of daily living. In stroke survivors with substantial physical impairments it may be difficult to assess changes in activities of daily living related to specifically cognitive problems . Usual definitions of dementia emphasize the presence of multidomain cognitive impairments, and in particular memory deficits. However, in stroke, it may be possible to have disabling cognitive problems but retain memory .
One of the main questions in the relationship between stroke and dementia occurring after the cerebrovascular event is whether the stroke causes the cognitive deterioration, contributes to it, or just alerted the physicians to the problem. The question remains to be answered, but undoubtedly about one-third of stroke survivors are found to have a significant degree of cognitive impairment within the first months after the event .
We propose the term PSD for any dementia which develops following a clinical cerebrovascular event. Although we use the descriptor “post-stroke”, emerging evidence suggests that transient ischemic attack may also be associated with adverse cognitive prognosis . Using the term PSD in this way does not suggest a particular underlying neuropathological process. This seems appropriate as dementia following stroke often comprises a mix of “vascular” insults and neurodegenerative processes . Stroke occurs predominantly in older adults and therefore stroke patients may have pre-stroke cognitive decline of varying severity . Recognizing the pre-stroke cognitive state is essential to allow appropriate classification, e.g., a patient with pre-existing cognitive impairment (diagnosed or undiagnosed) who then has a minor stroke should not be labeled as PSD.
The time assessment of cognitive impairment is another relevant diagnostic factor. Acute deficiencies in cognitive test scores are often observed following a stroke and retesting after several weeks often reveals improvements [14, 15]. Therefore, the final diagnosis of PSD should be delayed to at least 6 months after the event. We recognize that certain strategic infarcts (for example, in dominant medial temporal lobe) are associated with immediate cognitive syndromes; however, we would still reserve the dementia diagnosis until at least 6 months. This delay in applying a dementia diagnostic label is in keeping with International classification systems such as the American Psychiatric Association Diagnostic and Statistical Manual.
The definition we have proposed is in accordance with other groups. The Vascular Impairment of Cognition Classification Consensus Study (VICCCS; http://www.vicccs.info/) considered PSD as a major subtype of VCI and felt that this label should be used where there is a clear temporal relationship between stroke and cognitive decline. A national Korean study of VCI epidemiology defined PSD as any major cognitive impairment seen at more than 3 months after a stroke event, regardless of pre-stroke cognitive status .
Properties of selected post-stoke dementia assessment scales
Free to use
Time to administer (min)
Validated in stroke
Suitable for aphasia
Informant-based structured questionnaires can capture the patient’s cognitive state before the stroke. The Informant Questionnaire for Cognitive Decline in the Elderly (IQCODE) is the most commonly employed assessment ; it has reasonable accuracy in determining dementia, it is available in several languages, and can be completed in minutes using the short form version . IQCODE has been used for assessment of pre-stroke and post-stroke cognition and to aid prognosis; indeed, the properties of IQCODE vary according to the purpose of testing. Testing of cognition should be complemented by functional assessment. The modified Rankin Scale and Barthel Index are the most commonly used functional assessment tools . Post-stroke cognitive issues will often coexist with other neuropsychological problems and should be assessed by validated tools as, for example, language disorders (Frenchay Aphasia Screening Test), mood disorder (Hospital Anxiety Depression Scale), fatigue (Fatigue Severity Scale), delirium (Confusion Assessment Method), and apathy (Apathy Evaluation Scale).
Common stroke-related impairments can complicate assessment if, for example, the patient is unable to complete a pencil and paper task if the dominant hand is weak . Cognitive assessment in the presence of aphasia is particularly problematic. Tools designed for use in aphasia are available such as the Cognitive Assessment Scale for Stroke Patients, which can be administered without using language, and the Oxford Cognitive Screen .
Stroke is recognized as one of the major causes of adult disability globally. VaD including PSD is the second most common cause of cognitive decline, with only Alzheimer disease (AD) being more prevalent . The lifetime risk of developing either stroke or dementia at age of 65 is one in three in men and one in two in women . With changing population demographics, increased life expectancy and improved survival from stroke, the absolute numbers of patients with PSD will increase. However, due to its relation with stroke incidence, PSD might be reduced with improved stroke prevention.
Age (over 65 years)
Lower educational level
Index stroke factors
Supratentorial stroke location
Dominant hemisphere stroke
Cerebral small-vessel disease
Medial temporal lobe atrophy
Silent brain infarctions (SBI) are common findings in elderly patients, but their relationship to dementia remains uncertain. Bornstein et al.  studied admission CT scans of 175 consecutive patients without dementia, presenting with a first stroke incident. SBI were defined as CT evidence of stroke not compatible with the acute event. Stroke survivors were followed for their mental state for 5 years and the authors found that SBI did not predict the development of PSD.
According to study of Grau-Olivares and Arboix , ischemic cerebral small-vessel disease (SVD) should be regarded as a severe condition prodrome of subcortical VaD, rather than a relatively benign disorder, as considered earlier, especially since SVD can be seen on MRI studies (white matter lesions, lacunes, and microbleeds). Recent studies showed that the proportion of dementia caused by SVD ranges from 36 to 67% [9, 28, 31, 33]. Further, patients with a first-ever lacunar stroke present with cognitive impairment in more than half of cases and more than 55% of patients fulfill mild cognitive impairment criteria . Additionally, the presence of silent multiple lacunar infarctions in patients with first-ever lacunar stroke is an independent predictor of poor performance on executive functions and short delayed verbal memory tests. Thus, in the initial stages of SVD, mild neuropsychological abnormalities appear to be related to lacunes rather than to perivascular hyperintensities of vascular cause or leukoaraiosis .
A number of important prospective cohort studies have documented cognitive change following stroke [35, 36]. Meta-analysis of these studies suggests that some form of cognitive impairment affects up to one third of stroke survivors; this figure does not differentiate stroke etiology and may include a proportion (estimated at around 10%) with pre-stroke dementia. Prevalence of PSCI is higher in those with recurrent stroke events . These data might underestimate the true prevalence of post-stroke cognitive change as patients included in studies tend to exclude those with larger strokes who are unable to consent or attend follow-up visits . There are also issues with feasibility of cognitive testing and attrition to follow-up that will contribute to under-estimation of the true burden of cognitive impairment .
Biomarkers and predictors of PSD
Biomarkers for PSD may include neuroimaging measures and metabolic, genetic, and inflammatory mediators . Both neurodegenerative and vascular mechanisms are activated and probably result in overlapping processes, therefore sharing some pathological features and likely having some common biomarkers.
Genes underlying PSD and VCI may include those shared by VaD and AD, namely genes involved in the pathways of amyloid production or elimination (apolipoprotein E and possibly presenilin and APP) may confer susceptibility to develop dementia after vascular brain injury, thus explaining, at least in part, the well-known interaction and synergism between VaD and AD. Polymorphisms (SNPs) in genes reported as conferring susceptibility to develop PSD and VaD include the e4 allele of apolipoprotein E, a well-known risk factor for AD, although its association with VaD and PSD has been controversial [41–47]. Another reported SNP is in the gene encoding the angiotensin-converting enzyme, one of the enzymes in the renin-angiotensin system. Studies investigating the angiotensin-converting enzyme SNP as a predictor for post-stroke cognitive decline have yielded controversial data [48–52]. A genome-wide association study in the Rotterdam cohort revealed a genetic locus associated with VaD, located on the X chromosome close to the androgen receptor gene . An additional SNP is endothelial nitric oxide synthase, reported as associated with incident dementia in elderly stroke survivors . The main research areas currently being investigated are genetic predisposition, predominantly in genes linked to both AD and vascular disease and inflammatory response.
Cerebrospinal fluid (CSF) biomarkers
So far, the search for a precise and reliable biochemical indicator which would help establish the diagnosis of VaD and PSD has not been productive. Although, the Aβ-42 peptide and tau protein CSF levels are sensitive markers of AD, they showed the lowest specificity in VaD . Promising results were obtained measuring the levels of matrix-degrading metalloproteinases (MMPs) in CSF, such as gelatinase A (MMP-2) and gelatinase B (MMP-9) [56, 57]. Gelatinases interfere with molecules of the basal lamina, leading to proteolytic disruption of the blood brain barrier (BBB). Further, they are involved in myelin breakdown. Brain ischemia induces a gelatinase A and B elevation at different time points after the stroke. Recent studies showed that the MMP-9 CSF level is significantly higher in VaD patients compared to AD patients as well as elderly healthy subjects, and may help in distinguishing AD from VaD . Other CSF markers also reported as associated with VaD, and indirectly PSD, are levels of α-1 antitrypsin, plasminogen activator inhibitor-1, and apolipoprotein H .
Serum biomarkers, such as β secretase enzyme and receptor levels for advanced glycation end products, have been suggested to correlate with early PSCI . Homocysteine, vitamin B12, and folic acid levels were linked to PSCI; however, supplementation with B vitamins had no effect on the incidence of cognitive impairment or decline .
Inflammation in stroke seems to have both detrimental and beneficial effects. Activation of resident cells (microglia, astrocytes, and endothelial cells) appears to be neuroprotective and promotes brain regeneration/recovery, whereas recruitment of immune cells with a subsequent increase in the expression of inflammatory mediators, such as reactive oxygen species, cytokines, and chemokines, together with BBB disruption, could lead to edema and neuronal death . Chronic activation of innate immune responses can trigger neurotoxic pathways leading to progressive degeneration. Damaged neurons themselves may also exacerbate immune-mediated disease by release of chemokines and activation of microglia . Several recent longitudinal studies have investigated the relationship between inflammatory markers and PSD, but an association is not yet established. Erythrocyte sedimentation rate (ESR), C-reactive protein, interleukin 6, and interleukin 12 were suggested as predictors of PSCI [62, 63]. Recently, Kliper et al.  showed strong relationship between ESR and cognitive performance among stroke survivors, where higher ESR levels were associated with worse performance in cognitive tests, particularly memory scores. Findings from the TABASCO study have raised the possibility that many individuals with cerebrovascular ischemic events harbor a long and persistent pro-inflammatory background . Whether lowering inflammation can also prevent PSD needs to be addressed in prospective clinical trials.
Peripheral microRNA (miRNA) profiles as novel biomarkers
miRNAs are a type of small non-coding RNA molecules that act as endogenous regulators of gene expression by binding to complementary sequences of target messenger RNA. The dysregulation of miRNAs is thought to be involved in many diseases, and changes in the miRNA expression profile have been observed in cerebral ischemia and AD. Studies have demonstrated that serum miRNAs miR-93, miR-146a, and miR-31 were significantly up regulated in VaD compared to the controls; thus, they could serve as specific biomarkers to discriminate AD from VaD . Endogenous circulating miRNAs have been found to be stable and consistently detected in serum, plasma and other body fluids because of their packaging and secretion into the blood within exosomes. Currently, information regarding miRNAs in VaD and PSD studies is limited, but the potential diagnostic value of miRNAs is very promising. In conclusion, no molecular biomarkers have been confirmed as being specifically associated with PSD.
Neuroimaging in PSD provides significant information about the anatomical substrate of the disorder and has an important role in PSD diagnosis. Further, it adds to prediction of cognitive decline after stroke; for example, hippocampal atrophy is a strong predictor for PSD outcome [12, 66]. Most acute stroke patients undergo CT brain imaging and, therefore, CT studies are representative of the whole clinical population. In everyday practice, CT is performed mainly to exclude intracerebral hemorrhage and certain stroke mimics (e.g., brain tumors), and can often show early signs of ischemia, as well as old stroke lesions. Additionally, the presence and extension of cerebral atrophy and white matter lesions can easily be seen on brain CT scans. Such neuroimaging characteristics may help predict subsequent cognitive impairment [67, 68].
MRI represents the most significant neuroimaging modality in PSD. If not contraindicated, MRI, rather than CT, is preferred for daily, routine clinical use as well as in research studies since it has higher specificity and sensitivity for detecting pathological substrates . Neuroimaging standards with a generally accepted terminology allowing comparison of findings between different centers have been suggested (STandards for ReportIng Vascular changes on nEuroimaging, STRIVE) . A large number of studies recognized MRI signs of cerebral SVD (lacunes, white matter hyperintensities, microbleeds, silent infarcts, white matter changes), as well as global cerebral atrophy and medial-temporal lobe atrophy as determinants and predictors of PSD. Vascular lesions associated with PSD are mainly found in subcortical brain areas, especially including sub-frontal and orbitofrontal white matter circuits. These lesions include single infarction in strategic areas such as the dominant thalamus or angular gyrus, deep areas of frontal lobe, and the left hemisphere, as well as brain infarcts in both hemispheres and volume-driven infarctions reaching a critical threshold of brain tissue loss or injury . Additionally to size and location of the vascular lesion, the involvement of functional network fiber tracts, assessed by diffusion tensor imaging, may be crucial for cognitive impairment after stroke; its role is still being studied . Although brain atrophy is a frequent finding in cerebral SVD, the pathophysiological mechanisms are not fully elucidated. In a recent study, Duering et al.  showed that cortical neurodegeneration following ischemia in the subcortical region probably represents pathophysiological mechanisms for cerebral atrophy in cerebrovascular disease; they showed that subcortical infarcts trigger focal thinning in connected cortical areas. Additionally, patients with mild VCI showed clear progressive gray matter atrophy in cortical (temporal and frontal) and subcortical (pons, caudate and cerebellum) regions after first-ever lacunar stroke, in contrast to patients without initial cognitive impairment .
Mild to moderate stroke patients with pre-existing white matter lesions are more vulnerable to cognitive impairment regardless of their new ischemic lesions . Results from the SMART-MR study suggested that the interaction between brain atrophy and white matter hyperintensities or infarcts could aggravate cognitive decline . There is evidence of the role of hippocampal mean diffusivity in the post-stroke cognitive state, above and beyond that of volume and connectivity of this structure .
Imaging of cerebral blood flow and cerebral glucose metabolism, by FDG-PET in particular, has been applied for several years in the differentiation between dementias . However, functional and molecular imaging has a special role for research on the pathophysiology and the factors involved in development of PSD. Stroke and the deposition of amyloid in the cerebral cortex are both known risks for developing dementia [78, 79]. While animal models suggest that stroke-induced inflammation and amyloid deposition act synergetically , this relationship remains to be established in human stroke. Experimentally, large vessel infarcts or small striatal infarcts are larger in the presence of extracellular amyloid beta (Aβ) deposits, which are fundamental markers of AD. Patients with minor cerebral strokes and moderate AD lesions will develop the clinical manifestations of dementia. A reasonable question is whether the stroke was just a signal and not necessarily a player in the pathogenesis of cognitive deterioration. Additionaly, small striatal infarcts in the presence of high levels of amyloid in the brain exhibit a progression in infarct size over time with an enhanced degree of cognitive impairment, AD-type pathology, and neuroinflammation compared with striatal infarcts or high amyloid levels alone. Recently, it has been stated that stroke is a specific vascular risk factor for cognitive impairment . There is an overlap between VCI risk factors (hypertension, diabetes, and atherosclerosis) and those for stroke, as well as AD risk factors. Stroke may alter the clinical expression of a given load of AD pathology, but more studies are needed for definitive clarification of the relationships between stroke, AD, and cognitive detoriation.
The best way to prevent PSD is to prevent stroke recurrence and stroke severity through optimal acute treatment and intensive secondary prevention. Intravenous and intra-arterial interventions (if indicated), treatment in the stroke unit including prevention of complications, and early rehabilitation are thought to limit the damage from the stroke lesion and improve outcome . Secondary prevention includes medical interventions and lifestyle modification. To date, there is limited evidence for specific therapeutic strategies for preventing cognitive decline after stroke. However, aggressive treatment of vascular risk factors may potentially prevent PSD through prevention of the total vascular burden, including progression of vascular disease and vascular risk associated with dementia. An observational study showed reduced cognitive impairment in patients with appropriate vascular risk management post-stroke ; this included antiplatelet therapy, antihypertensive drugs and statins, or anticoagulants, if indicated. In addition, cognitive function can benefit from treatment of neuropsychiatric symptoms like depression, apathy, and anxiety, as well as cognitive training/stimulation .
In a pilot study, the relationship between amyloid deposition, microglia activation, and cognitive performance in stroke patients was investigated . Preliminary results suggest that cortical amyloid deposition and post-stroke white matter inflammation contribute to PSD, indicating that various pathophysiological mechanisms are involved. If confirmed in larger trials, this finding might offer possibilities for clinical intervention to prevent post-stroke cognitive decline by modulation of inflammation or amyloid deposition. In addition, endothelin dysfunction with secondary neuroinflammation seen in acute non-atherothrombotic etiology stroke can be a potential target for drug treatment .
Pharmacological interventions for prevention of PSD
Blood pressure lowering
A review by Zanchetti et al.  of randomized controlled trials (RCTs) not limited to stroke patients suggests that blood pressure lowering may have some beneficial effects on cognitive decline. Hypertension treatment after stroke preserves cognition through prevention of recurrent stroke, but it is not yet clear whether it prevents cognitive decline through other mechanisms. Thus far, only four published RCTs restricted to patients with a previous stroke tested the effect of antihypertensive drugs on cognition as secondary outcome. The Perindopril Protection Against Recurrent Stroke study showed that long-term blood pressure lowering after stroke with perindopril was associated with reduced cognitive decline . This effect was more pronounced in patients with recurrent stroke, suggesting a beneficial effect due to secondary stroke prevention. In contrast, telmisartan did not change cognition in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) study . Further, results of the Secondary Prevention of Small Subcortical Strokes (SPS3) trial showed no differences in cognitive function amongst groups according to blood pressure control or antiplatelet drug used . One study, with cognition as the primary outcome, did not find any association between cognitive test performance and different blood pressure goals . Similarly, candesartan did not improve cognitive function at 6 months when compared to placebo in the Scandinavian Candesartan Acute Stroke Trial (SCAST) .
Statin therapy in secondary stroke prevention has shown an effect on new vascular events but only marginally reduces the risk of stroke recurrence . Statins lower LDL cholesterol and may have a beneficial effect on platelet function, endothelial activity, and inflammation . No study has tested the effect of statins on cognition in patients with previous stroke. However, two large studies (HPS and PROSPER), which included patients with risk factors for, or a history of, vascular diseases, failed to show that either simvastatin or pravastatin affected cognition [94, 95].
Other potential pharmacological interventions
Many therapeutic strategies have been developed for neuroprotection in acute stoke. Nitric oxide donors are thought to reduce infarct size and improve cerebral blood flow, but did not improve cognitive function post-stroke . Acetylcholinesterase inhibitors and memantine may have a beneficial effect on cognition in patients with mild to moderate vascular dementia in general , but evidence for both general improvement are limited. Cerebrolysin had a beneficial effect on global outcome, but did not assess cognition, especially in stroke patients . Selective serotonin reuptake inhibitors may be associated with overall recovery after stroke even in the absence of depression . Fluoxetine is proposed to improve stroke recovery, and there is an ongoing trial that includes cognition as an outcome . The dietary nucleotide citicoline may also improve recovery . There are ongoing studies to explore the potential positive effect of phosphodiesterase-3, anti-inflammatory agents, BBB modulators, endothelin antagonist, flavonoids, immunosuppressive agents, peroxisome proliferator-activated receptor gamma antagonists, prostacylin, sympathomimetics, xanthine oxidase inhibitors, antidepressants, neurotrophic agents, gingko biloba extract Egb-761, and others [12, 102].
Most vascular risk factors are modifiable. Modifications of lifestyle factors include physical exercise, healthy diet, moderate alcohol consumption, and smoking cessation. Multimodal lifestyle interventions have been successful in changing the lifestyle habits of stroke survivors [103, 104]. Two randomized trials have been performed with multifactorial interventions including optimal medical treatment for secondary prevention in addition to physical activity, diet, weight control, smoking cessation, healthy diet with better glycemic control, and cognitive stimulation. One tested the effect of the multimodal risk factor intervention over 1 year on cognition, but no change in cognitive outcome was found . However, significant beneficial effects were found on depression as the secondary outcome . The recently published RCT by Matz et al.  showed that stroke patients receiving multiple, intensive life-style interventions did not differ in cognitive outcomes after 2 years compared to patients who received standard care; a small non-significant reduction in dysexecutive syndromes appearing in the intervention group was noted, but not significant. This finding indicates that studies for lifestyle interventions have to be performed in larger populations with neuropsychological functions as outcome measures, particularly the executive domains.
A systematic review including nine studies, published in 2012, showed that increased physical activity after stroke improves cognitive performance . Exercise training is standard for cardiovascular disease management, and cardiac rehabilitation was shown to improve cognitive performance in several studies . Sharing the same risk factors as stroke, brain rehabilitation including exercise might be a right strategy in future stroke care, supported by papers published over the past 2 years. A 6-month training model combining aerobic and resistance training, initiated at least 10 weeks post-stroke, resulted in improved cognitive function and reduction of patients meeting the threshold criteria for mild cognitive impairment . A recently published paper by Moore et al.  showed that exercise therapy three times per week for 19 weeks improved cognitive function, increased regional blood flow in the medial temporal lobe, and prevented structural loss in the same region. An ongoing RCT, Move IT, aims to investigate whether a physical exercise program can prevent cognitive decline in the acute phase after transient ischemic attack or minor ischemic stroke .
Cognitive rehabilitation is a complex therapeutic intervention aiming to improve cognitive function after stroke; at present, the approached strategies are individual remediation therapy with a neuropsychologist, group-based training, and computer cognitive training . Cognitive rehabilitation plays an integral role in stroke multidisciplinary rehabilitation and should be started shortly after stroke onset, with effectiveness both in the post-acute period and a few years after stroke . However, there are insufficient data to conclude on the long lasting benefits in memory and executive function for post-stroke survivors [114, 115]. Moreover, data is missing regarding whether the possible improvements in neuropsychological tests are related to improvement in everyday functional activities .
Non-invasive brain stimulation
Non-invasive brain stimulation techniques, including repetitive transcranial magnetic stimulation and transcranial direct current stimulation, have been reported to improve functional status of stroke patients through modulation of the excitability of cortical circuits [117, 118]. Nevertheless, most previous studies included a small number of participants and evaluated only the short-term effect. Therefore, there is limited evidence for recommendation of repetitive transcranial magnetic stimulation or transcranial direct current stimulation in the treatment of PSCI. Future studies are needed to elucidate appropriate stimulation sites, optimal parameters, and stimulation protocols to overcome individual differences such as skull shape or genetic polymorphisms .
Natural biological products, such as actovegin, may have beneficial effects in the restorative phase of ischemia . Elmilnger et al.  found protective and anti-oxidative effects of the hemodialysate actovegin on primary rat neurons in vitro. The efficacy of actovegin was investigated by Mikhaĭlova et al.  in the treatment of mild cognitive impairment post-stroke. The authors found a positive therapeutic effect, including increased speed of mental processes and reduced memory impairment as well as a positive impact on asthenic and depressive symptoms. In addition, the ARTEMIDA study explored whether this treatment has a disease-modifying effect on PSD . Actovegin has been shown to have effects on some cellular processes in the aging brain and recent experimental studies revealed actovegin to play a role in neuroprotective mechanisms .
Conclusions and further prospects
A variety of classifications, diagnostic criteria, and descriptive syndromes are used to define post-stroke cognitive problems, but a widely accepted and harmonized terminology is still missing. We propose the term PSD for any dementia following stroke that has a temporal relationship with stroke.
The best way to prevent PSD is optimal treatment to reduce stroke incidence and severity and, once stroke occurs, intensive prevention of early complications and long-term stroke recurrence. To date, there is limited evidence for specific therapeutic strategies for preventing cognitive decline after stroke. However, aggressive treatment of vascular risk factors, such as antiplatelet therapy, antihypertensives and statins, or anticoagulant therapy (if indicated), may potentially prevent PSD through inhibition of the total vascular burden, including progression of vascular disease and vascular risk associated with dementia. In addition, cognitive function can benefit from treatment of neuropsychiatric symptoms like depression, apathy, and anxiety, as well as cognitive training/stimulation.
In the future, it is necessary to introduce a uniform definition of cognitive impairment state following stroke, which should be widely accepted, leading to more accurate epidemiological results and a greater potential to compare and pool data. For this to be possible, all inclusion and exclusion criteria should be precisely defined, and in particular the time assessment of cognitive impairment following stroke. We propose that final diagnosis of PSD should be delayed to at least 6 months after the event.
One of the main strategies for easier identification of PSD is finding a precise biochemical marker. Since there is still no reliable marker, the search continues, with an enormous influence on future health economics and the development of preventative treatments and strategies. Therefore, multi-center studies on long-term cognitive outcomes in stroke patients should be given high priority.
Availability of data and materials
Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.
All authors contributed to the drafting and writing the manuscript, discussions and critical amendments, analysis and interpretation, literature search, data extractions, and critical revision of the manuscript for important intellectual content. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
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- Strong K, Mathers C, Bonita R. Preventing stroke: saving lives around the world. Lancet Neurol. 2007;6:182–7.PubMedView ArticleGoogle Scholar
- Lees R, Fearon P, Harrison JK, Broomfield NM, Quinn TJ. Cognitive and mood assessment in stroke research: focused review of contemporary studies. Stroke. 2012;43:1678–80.PubMedView ArticleGoogle Scholar
- McKevitt C, Fudge N, Redfern J, et al. Self-reported long term needs after stroke. Stroke. 2011;42:1398–3.PubMedView ArticleGoogle Scholar
- Pollock A, St George B, Fenton M, Firkins L. Top ten research priorities relating to life after stroke. Lancet Neurol. 2012;11:209.PubMedView ArticleGoogle Scholar
- Fride Y, Adamit T, Maeir A, Ben Assayag E, Bornstein NM, Korczyn AD, Katz N. What are the correlates of cognition and participation to return to work after first ever mild stroke? Top Stroke Rehabil. 2015;22(5):317–25.PubMedView ArticleGoogle Scholar
- Ritchie CW, Muniz Terrera G, Quinn TJ. Dementia trials and dementia tribulations: methodological and analytical challenges in dementia research. Alzheimers Res Ther. 2015;7:31.PubMedPubMed CentralView ArticleGoogle Scholar
- Pendlebury ST, Mariz J, Bull L, Mehta Z, Rothwell PM. Impact of different operational definitions on mild cognitive impairment rate and MMSE and MoCA performance in transient ischaemic attack and stroke. Cerebrovasc Dis. 2013;36:355–62.PubMedPubMed CentralView ArticleGoogle Scholar
- Ihle-Hansen H, Thommessen B, Wyller TB, Engedal K, Øksengård AR, Stenset V, Løken K, Aaberg M, Fure B. Incidence and subtypes of MCI and dementia 1 year after first-ever stroke in patients without pre-existing cognitive impairment. Dement Geriatr Cogn Disord. 2011;32:401–7.PubMedView ArticleGoogle Scholar
- Erkinjuntti T, Gauthier S. Diagnosing vascular cognitive impairment and dementia: concepts and controversies. In: Wahlund L, Erkinjuntti T, Gauthier S, editors. Vascular cognitive impairment in clinical practice. Cambridge: Cambridge University Press; 2009. p. 3–10.View ArticleGoogle Scholar
- Gorelick PB, Nyenhuis D. Stroke and cognitive decline. JAMA. 2015;314(1):29–30. doi:https://doi.org/10.1001/jama.2015.7149.PubMedView ArticleGoogle Scholar
- Van Rooij FG, Kessels RP, Richard E, De Leeuw FE, van Dijk EJ. Cognitive impairment in transient ischemic attack patients: a systematic review. Cerebrovasc Dis. 2016;42(1–2):1–9.PubMedView ArticleGoogle Scholar
- Brainin M, Tuomileheto J, Heiss WD, et al. Post-stroke cognitive decline: an update and perspectives for clinical research. Eur J Neurol. 2015;22:229–38.PubMedView ArticleGoogle Scholar
- Henon H, Pasquier F, Durieu I, et al. Pre-existing dementia in stroke patients: baseline frequency, associated factors, and outcome. Stroke. 1997;28:2429–36.PubMedView ArticleGoogle Scholar
- Wagle J, Farner L, Flekkøy K, et al. Early post-stroke cognition in stroke rehabilitation patients predicts functional outcome at 13 months. Dement Geriatr Cogn Disord. 2011;31:379–7.PubMedView ArticleGoogle Scholar
- Lees R, Stott DJ, Quinn TJ, Broomfield NM. Feasibility and diagnostic accuracy of early mood screening to diagnose persisting clinical depression/anxiety disorder after stroke. Cerebrovasc Dis. 2014;37:323–9.PubMedView ArticleGoogle Scholar
- Yu KH, Cho SJ, Oh MS, Jung S, Lee JH, Shin JH, Koh IS, Cha JK, Park JM, Bae HJ, Kang Y, Lee BC, Korean-Vascular Cognitive Impairment Harmonization Standards Study Group. Cognitive impairment evaluated with vascular cognitive impairment harmonization standards in a multicenter prospective stroke cohort in Korea. Stroke. 2013;44:786–8.PubMedView ArticleGoogle Scholar
- Hachinski V, Iadecola C, Petersen RC, Breteler MM, Nyenhuis DL, Black SE, et al. National Institute of neurological disorders and stroke Canadian stroke network vascular cognitive impairment harmonization standards. Stroke. 2006;37:2220–41.PubMedView ArticleGoogle Scholar
- Royal College of Physicians. National clinical guidelines for stroke clinical effectiveness and evaluation unit. London: Royal College of Physicians; 2012.Google Scholar
- Lees R, Corbet S, Johnston C, Moffitt E, Shaw G, Quinn TJ. Test accuracy of short screening tests for diagnosis of delirium or cognitive impairment in an acute stroke unit setting. Stroke. 2013;44:3078–3.PubMedView ArticleGoogle Scholar
- Ferris S. Report of the working group on clinical global measures. Position paper from the International working group on harmonization of dementia drug guidelines. Alzheimer Dis Assoc Disord. 1997;11 Suppl 3:8–18.Google Scholar
- Demeyere N, Riddoch MJ, Slavkova ED, Bickerton WL, Humphreys GW. The Oxford Cognitive Screen (OCS): validation of a stroke-specific short cognitive screening tool. Psychol Assess. 2015;27:883–94.PubMedView ArticleGoogle Scholar
- Lees R, Selvarajah J, Fenton C, Pendlebury ST, Langhorne P, Stott DJ, Quinn TJ. Test accuracy of cognitive screening tests for diagnosis of dementia and multidomain cognitive impairment in stroke. Stroke. 2014;45:3008–18.PubMedView ArticleGoogle Scholar
- Pendlebury ST, Klaus SP, Thomson RJ, Mehta Z, Wharton RM, Rothwell PM, Oxford Vascular Study. Methodological factors in determining risk of dementia after transient ischemic attack and stroke: (III) applicability of cognitive tests. Stroke. 2015;46:3067–73.PubMedView ArticleGoogle Scholar
- Tang WK, Chan SSM, Chiu HFK, Wong KS, Kwok TCY, Mok V, et al. Can IQCODE detect poststroke dementia? Int J Geriatr Psychiatry. 2003;18:706–10.PubMedView ArticleGoogle Scholar
- Harrison JK, Fearon P, Noel-Storr AH, McShane R, Stott DJ, Quinn TJ. IQCODE for diagnosis dementia in secondary care settings. Cochrane Database Syst Rev. 2015;3:CD010772.Google Scholar
- Quinn TJ, Dawson J, Walters MR, Lees KR. Functional outcome measures in contemporary stroke trials. Int J Stroke. 2009;3:200–5.View ArticleGoogle Scholar
- Lees RA, Hendry Ba K, Broomfield N, Stott D, Larner AJ, Quinn TJ. Cognitive assessment in stroke: feasibility and test properties using differing approaches to scoring of incomplete items. Int J Geriatr Psychiatry. 2016. Ahead of print. doi:https://doi.org/10.1002/gps.4568.
- Seshadri S, Wolf PA. Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham study. Lancet. 2007;3:1106–14.View ArticleGoogle Scholar
- Henon H, Pasquier F, Leys D. Poststroke dementia. Cerebrovasc Dis. 2006;22:61–70.PubMedView ArticleGoogle Scholar
- Pasquier F, Hénon H, Leys D. Risk factors and mechanisms of post-stroke dementia. Rev Neurol. 1999;155(9):749–53.PubMedGoogle Scholar
- Pendlebury ST, Rothwell PM. Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis. Lancet Neurol. 2009;8:1006–18.PubMedView ArticleGoogle Scholar
- Bornstein NM, Gur AY, Treves TA, Reider-Groswasser I, Aronovich BD, Klimovitzky SS, Varssano D, Korczyn AD. Do silent brain infarctions predict the development of dementia after first ischemic stroke? Stroke. 1996;27(5):904–5.PubMedView ArticleGoogle Scholar
- Grau-Olivares M, Arboix A. Mild cognitive impairment in stroke patients with ischemic cerebral small-vessel disease: a forerunner of vascular dementia? Expert Rev Neurother. 2009;9(8):1201–17.PubMedView ArticleGoogle Scholar
- Blanco-Rojas L, Arboix A, Canovas D, Grau-Olivares M, Oliva Morera JC, Parra O. Cognitive profile in patients with a first-ever lacunar infarct with and without silent lacunes: a comparative study. BMC Neurol. 2013;13:203.PubMedPubMed CentralView ArticleGoogle Scholar
- Ben Assayag E, Korczyn AD, Giladi N, Goldbourt U, Berliner AS, Shenhar-Tsarfaty S, Kliper E, Hallevi H, Shopin L, Hendler T, Baashat DB, Aizenstein O, Soreq H, Katz N, Solomon Z, Mike A, Usher S, Hausdorff JM, Auriel E, Shapira I, Bornstein NM. Predictors for poststroke outcomes: the Tel Aviv brain acute stroke cohort (TABASCO) study protocol. Int J Stroke. 2012;7:341–7.PubMedView ArticleGoogle Scholar
- Wollenweber FA, Zietemann V, Rominger A, Opherk C, Bayer-Karpinska A, Gschwendtner A, Coloma Andrews L, Bürger K, Duering M, Dichgans M. The determinants of dementia after stroke (DEDEMAS) study: protocol and pilot data. Int J Stroke. 2014;9:387–92.PubMedView ArticleGoogle Scholar
- Pendlebury ST, Chen PJ, Welch SJ, Cuthbertson FC, Wharton RM, Mehta Z, Rothwell PM, Oxford Vascular Study. Methodological factors in determining risk of dementia after transient ischemic attack and stroke: (I) impact of baseline selection bias. Stroke. 2015;46:641–6.PubMedPubMed CentralView ArticleGoogle Scholar
- Pendlebury ST, Chen PJ, Welch SJ, Cuthbertson FC, Wharton RM, Mehta Z, Rothwell PM, Oxford Vascular Study. Methodological factors in determining risk of dementia after transient ischemic attack and stroke: (II) effect of attrition on follow-up. Stroke. 2015;46:1494–500.PubMedPubMed CentralView ArticleGoogle Scholar
- Levine DA, Galecki AT, Langa KM, Unverzagt FW, Kabeto MU, Giordani B, Wadley VG. Trajectory of cognitive decline after incident stroke. JAMA. 2015;314(1):41–51.PubMedPubMed CentralView ArticleGoogle Scholar
- Bornstein NM, Aronovich B, Korczyn AD, Shavit S, Michaelson DM, Chapman J. Antibodies to brain antigens following stroke. Neurology. 2001;56(4):529–30.PubMedView ArticleGoogle Scholar
- Hsiung GY, Sadovnick AD, Feldman H. Apolipoprotein E epsilon4 genotype as a risk factor for cognitive decline and dementia: data from the Canadian study of health and aging. CMAJ. 2004;171:863–7.PubMedPubMed CentralView ArticleGoogle Scholar
- Jin YP, Ostbye T, Feightner JW, Di Legge S, Hachinski V. Joint effect of stroke and APOE4 on dementia risk: the Canadian study of health and aging. Neurology. 2008;70:9–16.PubMedView ArticleGoogle Scholar
- Kolsch H, Jessen F, Freymann N, et al. ACE I/D polymorphism is a risk factor of alzheimer’s disease but not of vascular dementia. Neurosci Lett. 2005;377:37–9.PubMedView ArticleGoogle Scholar
- Mortimer JA, Snowdon DA, Markesbery WR. The effect of APOE-epsilon 4 on dementia is mediated by alzheimer neuropathology. Alzheimer Dis Assoc Disord. 2009;23:152–7.PubMedPubMed CentralView ArticleGoogle Scholar
- Qian L, Ding L, Cheng L, et al. Early biomarkers for post-stroke cognitive impairment. J Neurol. 2012;259:2111–8.PubMedView ArticleGoogle Scholar
- Rippon GA, Tang MX, Lee JH, Lantigua R, Medrano M, Mayeux R. Familial alzheimer disease in Latinos: interaction between APOE, stroke, and estrogen replacement. Neurology. 2006;66:35–40.PubMedPubMed CentralView ArticleGoogle Scholar
- Treves TA, Bornstein NM, Chapman J, Klimovitzki S, Verchovsky R, Asherov A, Veshchev IO, Korczyn AD. APOE-epsilon 4 in patients with alzheimer disease and vascular dementia. Alzheimer Dis Assoc Disord. 1996;10(4):189–91.PubMedView ArticleGoogle Scholar
- Bour AM, Rasquin SM, Baars L, et al. The effect of the APOE-epsilon 4 allele and ACE-I/D polymorphism on cognition during a two-year follow-up in first-ever stroke patients. Dement Geriatr Cogn Disord. 2010;29:534–42.PubMedView ArticleGoogle Scholar
- Baum L, Chen X, Cheung WS, et al. Polymorphisms and vascular cognitive impairment after ischemic stroke. J Geriatr Psychiatry Neurol. 2007;20:93–9.PubMedView ArticleGoogle Scholar
- Arpa A, del Ser T, Goda G, Barba R, Bornstein B. Apolipoprotein E, angiotensin-converting enzyme and alpha-1-antichymotrypsin genotypes are not associated with post-stroke dementia. J Neurol Sci. 2003;210:77–82.PubMedView ArticleGoogle Scholar
- Slooter AJ, Tang MX, van Duijn CM, et al. Apolipoprotein E epsilon4 and the risk of dementia with stroke: a population-based investigation. JAMA. 1997;277:818–21.PubMedView ArticleGoogle Scholar
- Chapman J, Wang N, Treves TA, Korczyn AD, Bornstein NM. ACE, MTHFR, factor V Leiden, and APOE polymorphisms in patients with vascular and alzheimer’s dementia. Stroke. 1998;29(7):1401–4.PubMedView ArticleGoogle Scholar
- Schrijvers EM, Schurmann B, Koudstaal PJ, et al. Genome-wide association study of vascular dementia. Stroke. 2012;43:315–9.PubMedView ArticleGoogle Scholar
- Morris CM, Ballard CG, Allan L, et al. NOS3 gene rs1799983 polymorphism and incident dementia in elderly stroke survivors. Neurobiol Aging. 2011;32:554e1–e6.View ArticleGoogle Scholar
- Battistin L, Cagnin A. Vascular cognitive disorder. A biological and clinical overview. Neurochem Res. 2010;35:1933–8.PubMedView ArticleGoogle Scholar
- Adair JC, Charlie J, Dencoff JE, et al. Measurement of gelatinase B (MMP-9) in the cerebrospinal fluid of patients with vascular dementia and alzheimer disease. Stroke. 2004;35:e159–62.PubMedView ArticleGoogle Scholar
- Candelario-Jalil E, Thompson J, Taheri S, et al. Matrix metalloproteinases are associated with increased blood–brain barrier opening in vascular cognitive impairment. Stroke. 2011;42:1345–50.PubMedPubMed CentralView ArticleGoogle Scholar
- Wallin A, Ohrfelt A, Bjerke M. Characteristic clinical presentation and CSF biomarker pattern in cerebral small vessel disease. J Neurol Sci. 2012;322:192–6.PubMedView ArticleGoogle Scholar
- Hankey GJ, Ford AH, Yi Q, et al. Effect of B vitamins and lowering homocysteine on cognitive impairment in patients with previous stroke or transient ischemic attack: a prespecified secondary analysis of a randomized, placebo-controlled trial and meta-analysis. Stroke. 2013;44:2232–9.PubMedView ArticleGoogle Scholar
- Jin R, Yang G, Li G. Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukoc Biol. 2010;87(5):779–89.PubMedPubMed CentralView ArticleGoogle Scholar
- Zhang L, Yang L. Anti-inflammatory effects of vinpocetine in atherosclerosis and ischemic stroke: a review of the literature. Molecules. 2014;20(1):335–47.PubMedView ArticleGoogle Scholar
- Rothenburg LS, Herrmann N, Swardfager W, et al. The relationship between inflammatory markers and post stroke cognitive impairment. J Geriatr Psychiatry Neurol. 2010;23:199–205.PubMedView ArticleGoogle Scholar
- Narasimhalu K, Lee J, Leong YL, et al. Inflammatory markers and their association with post stroke cognitive decline. Int J Stroke. 2015;10:513–8.PubMedView ArticleGoogle Scholar
- Kliper E, Bashat DB, Bornstein NM, et al. Cognitive decline after stroke: relation to inflammatory biomarkers and hippocampal volume. Stroke. 2013;44:1433–5.PubMedView ArticleGoogle Scholar
- Dong H, Li J, Huang L, et al. Serum MicroRNA profiles serve as novel biomarkers for the diagnosis of alzheimer’s disease. Dis Markers. 2015;2015:625659.PubMedPubMed CentralGoogle Scholar
- Mehrabian S, Raycheva M, Petrova N, Janyan A, Petrova M, Traykov L. Neuropsychological and neuroimaging markers in prediction of cognitive impairment after ischemic stroke: a prospective follow-up study. Neuropsychiatr Dis Treat. 2015;11:2711–9.PubMedPubMed CentralView ArticleGoogle Scholar
- Wattjes MP, Henneman WJ, van der Flier WM, et al. Diagnostic imaging of patients in a memory clinic: comparison of MR imaging and 64-detector row CT. Radiology. 2009;253:174–83.PubMedView ArticleGoogle Scholar
- Wahlund LO, Barkhof F, Fazekas F, et al. A new rating scale for age-related white matter changes applicable to MRI and CT. Stroke. 2001;32:1318–22.PubMedView ArticleGoogle Scholar
- Wardlaw JM, Smith EE, Biessels GJ, et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol. 2013;12:822–38.PubMedPubMed CentralView ArticleGoogle Scholar
- Grysiewicz R, Gorelick PB. Key neuroanatomical structures for post-stroke cognitive impairment. Curr Neurol Neurosci Rep. 2012;12(6):703–8.PubMedView ArticleGoogle Scholar
- Heiss WD, Kidwell CS. Imaging for prediction of functional outcome and assessment of recovery in ischemic stroke. Stroke. 2014;45(4):1195–201.PubMedPubMed CentralView ArticleGoogle Scholar
- Duering M, Righart R, Csanadi E, Jouvent E, Hervé D, Chabriat H, Dichgans M. Incident subcortical infarcts induce focal thinning in connected cortical regions. Neurology. 2012;79(20):2025–8.PubMedView ArticleGoogle Scholar
- Grau-Olivares M, Arboix A, Junqué C, Arenaza-Urquijo EM, Rovira M, Bartrés-Faz D. Progressive gray matter atrophy in lacunar patients with vascular mild cognitive impairment. Cerebrovasc Dis. 2010;30(2):157–66.PubMedView ArticleGoogle Scholar
- Kliper E, Ben Assayag E, Tarrasch R, Artzi M, Korczyn AD, Shenhar-Tsarfaty S, Aizenstein O, Hallevi H, Mike A, Shopin L, Bornstein NM, Ben BD. Cognitive state following stroke: the predominant role of preexisting white matter lesions. PLoS One. 2014;9(8):e105461.PubMedPubMed CentralView ArticleGoogle Scholar
- Kooistra M, Geerlings MI, van der Graaf Y, et al. Vascular brain lesions, brain atrophy, and cognitive decline. The second manifestations of ARTerial disease – magnetic resonance (SMART-MR) study. Neurobiol Aging. 2014;35:35–41.PubMedView ArticleGoogle Scholar
- Kliper E, Ben Assayag E, Korczyn AD, Auriel E, Shopin L, Hallevi H, Shenhar-Tsarfaty S, Mike A, Artzi M, Klovatch I, Bornstein NM, Ben BD. Cognitive state following mild stroke: a matter of hippocampal mean diffusivity. Hippocampus. 2016;26(2):161–9. doi:https://doi.org/10.1002/hipo.22500.PubMedView ArticleGoogle Scholar
- Heiss W-D, Zimmermann-Meinzingen S. PET imaging in the differential diagnosis of vascular dementia. J Neurol Sci. 2012;322:268–73.PubMedView ArticleGoogle Scholar
- Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR. Brain infarction and the clinical expression of alzheimer disease. JAMA. 1997;277:813–7.PubMedView ArticleGoogle Scholar
- Leys D, Henon H, Mackowiak-Cordoliani MA, Pasquier F. Poststroke dementia. Lancet Neurol. 2005;4:752–9.PubMedView ArticleGoogle Scholar
- Cechetto DF, Hachinski V, Whitehead SN. Vascular risk factors and alzheimer’s disease. Expert Rev Neurother. 2008;8:743–50.PubMedView ArticleGoogle Scholar
- Pendlebury ST. Dementia in patients hospitalized with stroke: rates, time course, and clinico-pathologic factors. Int J Stroke. 2012;7(7):570–81.PubMedView ArticleGoogle Scholar
- Douiri A, McKevitt C, Emmett ES, Rudd AG, Wolfe CD. Long-term effects of secondary prevention on cognitive function in stroke patients. Circulation. 2013;128(12):1341–8.PubMedView ArticleGoogle Scholar
- Woods B, Aguirre E, Spector AE, Orrell M. Cognitive stimulation to improve cognitive functioning in people with dementia. Cochrane Database Syst Rev. 2012;2:CD005562.Google Scholar
- Thiel A, Cechetto DF, Heiss WD, Hachinski V, Whitehead SN. Amyloid burden, neuroinflammation, and links to cognitive decline after ischemic stroke. Stroke. 2014;45:2825–9.PubMedView ArticleGoogle Scholar
- Arboix A, Blanco-Rojas L, Martí-Vilalta JL. Advancements in understanding the mechanisms of symptomatic lacunar ischemic stroke: translation of knowledge to prevention strategies. Expert Rev Neurother. 2014;14(3):261–76.PubMedView ArticleGoogle Scholar
- Zanchetti A, Liu L, Mancia G, Parati G, Grassi G, Stramba-Badiale M, et al. Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient: design of the European society of hypertension-Chinese hypertension league stroke in hypertension optimal treatment randomized trial. J Hypertension. 2014;32(9):1888–97.View ArticleGoogle Scholar
- PROGRESS Collaborative Group. Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack. Lancet. 2001;358(9287):1033–41. Erratum in: Lancet. 2001;358(9292):1556. Lancet. 2002;359(9323):2120.Google Scholar
- Diener HC, Sacco RL, Yusuf S, Cotton D, Ounpuu S, Lawton WA, et al. Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the prevention regimen for effectively avoiding second strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study. Lancet Neurol. 2008;7(10):875–84.PubMedPubMed CentralView ArticleGoogle Scholar
- Pearce LA, McClure LA, Anderson DC, Jacova C, Sharma M, Hart RG, et al. Effects of long-term blood pressure lowering and dual antiplatelet treatment on cognitive function in patients with recent lacunar stroke: a secondary analysis from the SPS3 randomised trial. Lancet Neurol. 2014;13(12):1177–85.PubMedPubMed CentralView ArticleGoogle Scholar
- Ihle-Hansen H, Thommessen B, Fagerland MW, Øksengård AR, Wyller TB, Engedal K, Fure B. Blood pressure control to prevent decline in cognition after stroke. Vasc Health Risk Manag. 2015;11:311–6. doi:https://doi.org/10.2147/VHRM.S82839.PubMedPubMed CentralView ArticleGoogle Scholar
- Hornslien AG, Sandset EC, Bath PM, Wyller TB, Berge E. Effects of candesartan in acute stroke on cognitive function and quality of life: results from the Scandinavian candesartan acute stroke trial. Stroke. 2013;44(7):2022–4.PubMedView ArticleGoogle Scholar
- Manktelow BN, Potter JF. Interventions in the management of serum lipids for preventing stroke recurrence. Cochrane Database Syst Rev. 2009;3:CD002091.Google Scholar
- Collins R, Armitage J, Parish S, Sleight P, Peto R. Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20536 people with cerebrovascular disease or other high-risk conditions. Lancet. 2004;363(9411):757–67.PubMedView ArticleGoogle Scholar
- O’Brien EC, Greiner MA, Xian Y, Fonarow GC, Olson DM, Schwamm LH, et al. Clinical effectiveness of statin therapy after ischemic stroke: primary results from the statin therapeutic area of the patient-centered research into outcomes stroke patients prefer and effectiveness research (PROSPER) study. Circulation. 2015;132(15):1404–13.PubMedView ArticleGoogle Scholar
- Bath PM, Woodhouse L, Scutt P, Krishnan K, Wardlaw JM, Bereczki D, et al. Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial. Lancet. 2015;385(9968):617–28.PubMedView ArticleGoogle Scholar
- Kavirajan H, Schneider LS. Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials. Lancet Neurol. 2007;6(9):782–92.PubMedView ArticleGoogle Scholar
- Ballard C, Sauter M, Scheltens P, He Y, Barkhof F, van Straaten EC, et al. Efficacy, safety and tolerability of rivastigmine capsules in patients with probable vascular dementia: the VantagE study. Curr Med Res Opin. 2008;24(9):2561–74.PubMedView ArticleGoogle Scholar
- Muresanu DF, Heiss WD, Hoemberg V, Bajenaru O, Popescu CD, Vester JC, et al. Cerebrolysin and recovery after stroke (CARS): a randomized, placebo-controlled, double-blind, multicenter trial. Stroke. 2016;47(1):151–9.PubMedView ArticleGoogle Scholar
- Mead GE, Hsieh CF, Hackett M. Selective serotonin reuptake inhibitors for stroke recovery. JAMA. 2013;310(10):1066–7.PubMedView ArticleGoogle Scholar
- Mead G, Hackett M, Lundstrom E, Murray V, Hankey G, Dennis M. The FOCUS, AFFINITY and EFFECTS trials studying the effect(s) of fluoxetine in patients with a recent stroke: a study protocol for three multicentre randomised controlled trials. Trials. 2015;16:369.PubMedPubMed CentralView ArticleGoogle Scholar
- Alvarez-Sabin J, Roman GC. The role of citicoline in neuroprotection and neurorepair in ischemic stroke. Brain Sci. 2013;3(3):1395–414.PubMedPubMed CentralView ArticleGoogle Scholar
- Wang X, Li J, Qian L, Zang XF, Zhang SY, Wang XY, Jin JL, Zhu XL, Zhang XB, Wang ZY, Xu Y. Icariin promotes histone acetylation and attenuates post-stroke cognitive impairment in the central cholinergic circuits of mice. Neuroscience. 2013;236:281–8. doi:https://doi.org/10.1016/j.neuroscience.2012.12.074.PubMedView ArticleGoogle Scholar
- Lennon O, Galvin R, Smith K, Doody C, Blake C. Lifestyle interventions for secondary disease prevention in stroke and transient ischaemic attack: a systematic review. Eur J Prev Cardiol. 2014;21(8):1026–39.PubMedView ArticleGoogle Scholar
- Sun JH, Tan L, Yu JT. Post-stroke cognitive impairment: epidemiology, mechanisms and management. Ann Transl Med. 2014;2(8):80.PubMedPubMed CentralGoogle Scholar
- Ihle-Hansen H, Thommessen B, Fagerland MW, Oksengard AR, Wyller TB, Engedal K, et al. Multifactorial vascular risk factor intervention to prevent cognitive impairment after stroke and TIA: a 12-month randomized controlled trial. Int J Stroke. 2014;9(7):932–8.PubMedView ArticleGoogle Scholar
- Ihle-Hansen H, Thommessen B, Fagerland MW, Oksengard AR, Wyller TB, Engedal K, et al. Effect on anxiety and depression of a multifactorial risk factor intervention program after stroke and TIA: a randomized controlled trial. Aging Ment Health. 2014;18(5):540–6.PubMedView ArticleGoogle Scholar
- Matz K, Teuschl Y, Firlinger B, Dachenhausen A, Keindl M, Seyfang L, et al. Multidomain lifestyle interventions for the prevention of cognitive decline after ischemic stroke: randomized trial. Stroke. 2015;46(10):2874–80.PubMedView ArticleGoogle Scholar
- Cumming TB, Tyedin K, Churilov L, Morris ME, Bernhardt J. The effect of physical activity on cognitive function after stroke: a systematic review. Int Psychogeriatr. 2012;24(4):557–67.PubMedView ArticleGoogle Scholar
- Stanek KM, Gunstad J, Spitznagel MB, Waechter D, Hughes JW, Luyster F, et al. Improvements in cognitive function following cardiac rehabilitation for older adults with cardiovascular disease. Int J Neurosci. 2011;121(2):86–93.PubMedView ArticleGoogle Scholar
- Marzolini S, Oh P, McIlroy W, Brooks D. The effects of an aerobic and resistance exercise training program on cognition following stroke. Neurorehabil Neural Repair. 2013;27(5):392–402.PubMedView ArticleGoogle Scholar
- Moore SA, Hallsworth K, Jakovljevic DG, Blamire AM, He J, Ford GA, et al. Effects of community exercise therapy on metabolic, brain, physical, and cognitive function following stroke: a randomized controlled pilot trial. Neurorehabil Neural Repair. 2015;29(7):623–35.PubMedView ArticleGoogle Scholar
- Boss HM, Van Schaik SM, Deijle IA, de Melker EC, van den Berg BT, Scherder EJ, et al. A randomised controlled trial of aerobic exercise after transient ischaemic attack or minor stroke to prevent cognitive decline: the MoveIT study protocol. BMJ Open. 2014;4(12):e007065.PubMedPubMed CentralView ArticleGoogle Scholar
- Cicerone KD, Langenbahn DM, Braden C, Malec JF, Kalmar K, Fraas M, et al. Evidence-based cognitive rehabilitation: updated review of the literature from 2003 through 2008. Arch Phys Med Rehabil. 2011;92(4):519–30.PubMedView ArticleGoogle Scholar
- Nair RD, Lincoln NB. Cognitive rehabilitation for memory deficits following stroke. Cochrane Database Syst Rev. 2007;3:CD002293.Google Scholar
- Chung CS, Pollock A, Campbell T, Durward BR, Hagen S. Cognitive rehabilitation for executive dysfunction in adults with stroke or other adult non-progressive acquired brain damage. Cochrane Database Syst Rev. 2013;4:CD008391.Google Scholar
- Cha YJ, Kim H. Effect of computer-based cognitive rehabilitation (CBCR) for people with stroke: a systematic review and meta-analysis. NeuroRehabilitation. 2013;32(2):359–68.PubMedView ArticleGoogle Scholar
- Nitsche MA, Paulus W. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol. 2000;527(Pt 3):633–9.PubMedPubMed CentralView ArticleGoogle Scholar
- Siebner HR, Rothwell J. Transcranial magnetic stimulation: new insights into representational cortical plasticity. Exp Brain Res. 2003;148:1–16.PubMedView ArticleGoogle Scholar
- Chang WH, Bang OY, Shin YI, Lee A, Pascual-Leone A, Kim YH. BDNF polymorphism and differential rTMS effects on motor recovery of stroke patients. Brain Stimul. 2014;7:553–8.PubMedView ArticleGoogle Scholar
- Korczyn AD, Brainin M, Guekht A. Neuroprotection in ischemic stroke: what does the future hold? Expert Rev Neurother. 2015;15(3):227–9.PubMedView ArticleGoogle Scholar
- Elmlinger MW, Kriebel M, Ziegler D. Neuroprotective and anti-oxidative effects of the hemodialysate actovegin on primary rat neurons in vitro. Neuromolecular Med. 2011;13(4):266–74.PubMedPubMed CentralView ArticleGoogle Scholar
- Mikhaĭlova NM, Selezneva ND, Kalyn IaB, Roshchina IF, Gavrilova SI. [Efficacy of actovegin in the treatment of elderly patients with vascular mild cognitive impairment.] Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(7 Pt 2):69–76. [In Russian].Google Scholar
- Guekht A, Skoog I, Korczyn AD, Zakharov V, Eeg M, Vigonius U. A randomised double-blind, placebo-controlled trial of actovegin in patients with post-stroke cognitive impairment: ARTEMIDA study design. Dement Geriatr Cogn Dis Extra. 2013;3(1):459–67.PubMedPubMed CentralView ArticleGoogle Scholar
- Skoog I, Korczyn AD, Guekht A. Neuroprotection in vascular dementia: a future path. J Neurol Sci. 2012;322(1–2):232–6.PubMedView ArticleGoogle Scholar