Tynkkynen J, Chouraki V, van der Lee SJ, Hernesniemi J, Yang Q, Li S, et al. Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: a prospective study in eight cohorts. Alzheimers Dement. 2018;14(6):723–33.
Article
PubMed
PubMed Central
Google Scholar
Prince MJ, Wimo A, Guerchet MM, Ali GC, Wu Y-T, Prina M. World Alzheimer Report 2015 - The Global Impact of Dementia. London: Alzheimer's Disease International; 2015.
Google Scholar
Shah H, Albanese E, Duggan C, Rudan I, Langa KM, Carrillo MC, et al. Research priorities to reduce the global burden of dementia by 2025. Lancet Neurol. 2016;15(12):1285–94.
Article
PubMed
Google Scholar
Varma VR, Oommen AM, Varma S, Casanova R, An Y, Andrews RM, et al. Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: a targeted metabolomics study. PLoS Med. 2018;15(1):e1002482.
Article
PubMed
PubMed Central
CAS
Google Scholar
Huo Z, Yu L, Yang J, Zhu Y, Bennett DA, Zhao J. Brain and blood metabolome for Alzheimer's dementia: findings from a targeted metabolomics analysis. Neurobiol Aging. 2020;86:123–33.
Article
CAS
PubMed
Google Scholar
Saji N, Murotani K, Hisada T, Kunihiro T, Tsuduki T, Sugimoto T, et al. Relationship between dementia and gut microbiome-associated metabolites: a cross-sectional study in Japan. Sci Rep. 2020;10(1):8088.
Article
CAS
PubMed
PubMed Central
Google Scholar
Oresic M, Hyotylainen T, Herukka SK, Sysi-Aho M, Mattila I, Seppanan-Laakso T, et al. Metabolome in progression to Alzheimer's disease. Transl Psychiatry. 2011;1:e57.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mapstone M, Cheema AK, Fiandaca MS, Zhong X, Mhyre TR, MacArthur LH, et al. Plasma phospholipids identify antecedent memory impairment in older adults. Nat Med. 2014;20(4):415–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mousavi M, Jonsson P, Antti H, Adolfsson R, Nordin A, Bergdahl J, et al. Serum metabolomic biomarkers of dementia. Dement Geriatr Cogn Dis Extra. 2014;4(2):252–62.
Article
PubMed
PubMed Central
Google Scholar
Graham SF, Chevallier OP, Elliott CT, Holscher C, Johnston J, McGuinness B, et al. Untargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-arginine metabolism in mild cognitive impairment subjects converting to Alzheimer's disease. PLoS One. 2015;10(3):e0119452.
Article
PubMed
PubMed Central
CAS
Google Scholar
Casanova R, Varma S, Simpson B, Kim M, An Y, Saldana S, et al. Blood metabolite markers of preclinical Alzheimer's disease in two longitudinally followed cohorts of older individuals. Alzheimers Dement. 2016;12(7):815–22.
Article
PubMed
PubMed Central
Google Scholar
Abdullah L, Evans JE, Emmerich T, Crynen G, Shackleton B, Keegan AP, et al. APOE epsilon4 specific imbalance of arachidonic acid and docosahexaenoic acid in serum phospholipids identifies individuals with preclinical Mild Cognitive Impairment/Alzheimer's Disease. Aging (Albany NY). 2017;9(3):964–85.
Article
CAS
Google Scholar
Li D, Misialek JR, Boerwinkle E, Gottesman RF, Sharrett AR, Mosley TH, et al. Prospective associations of plasma phospholipids and mild cognitive impairment/dementia among African Americans in the ARIC Neurocognitive Study. Alzheimers Dement (Amst). 2017;6:1–10.
Article
Google Scholar
Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 2015;12(3):e1001779. https://doi.org/10.1371/journal.pmed.1001779.
Article
PubMed
PubMed Central
Google Scholar
Soininen P, Kangas AJ, Wurtz P, Suna T, Ala-Korpela M. Quantitative serum nuclear magnetic resonance metabolomics in cardiovascular epidemiology and genetics. Circ Cardiovasc Genet. 2015;8(1):192–206.
Article
CAS
PubMed
Google Scholar
Wurtz P, Kangas AJ, Soininen P, Lawlor DA, Davey Smith G, Ala-Korpela M. Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Large-Scale Epidemiology: A Primer on -Omic Technologies. Am J Epidemiol. 2017;186(9):1084–96.
Article
PubMed
PubMed Central
Google Scholar
Soininen P, Kangas AJ, Wurtz P, Tukiainen T, Tynkkynen T, Laatikainen R, et al. High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism. Analyst. 2009;134(9):1781–5.
Article
CAS
PubMed
Google Scholar
Plassman BL, Langa KM, Fisher GG, Heeringa SG, Weir DR, Ofstedal MB, et al. Prevalence of dementia in the United States: the aging, demographics, and memory study. Neuroepidemiology. 2007;29(1-2):125–32.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ou Y-N, Tan C-C, Shen X-N, Xu W, Hou X-H, Dong Q, et al. Blood pressure and risks of cognitive impairment and dementia: a systematic review and meta-analysis of 209 prospective studies. Hypertension. 2020;76(1):217–25.
Article
CAS
PubMed
Google Scholar
Walker KA, Power MC, Gottesman RF. Defining the relationship between hypertension, cognitive decline, and dementia: a review. Curr Hypertens Rep. 2017;19(3):24.
Article
PubMed
PubMed Central
Google Scholar
Biessels GJ, Despa F. Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications. Nat Rev Endocrinol. 2018;14(10):591–604.
Article
PubMed
PubMed Central
Google Scholar
Durazzo TC, Mattsson N, Weiner MW. Initiative AsDN: Smoking and increased Alzheimer's disease risk: a review of potential mechanisms. Alzheimers Dement. 2014;10:S122–45.
Article
PubMed
PubMed Central
Google Scholar
Hachinski V, Einhäupl K, Ganten D, Alladi S, Brayne C, Stephan BC, et al. Preventing dementia by preventing stroke: the Berlin Manifesto. Alzheimers Dement. 2019;15(7):961–84.
Article
PubMed
PubMed Central
Google Scholar
Gorelick PB, Scuteri A, Black SE, DeCarli C, Greenberg SM, Iadecola C, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42(9):2672–713.
Article
PubMed
PubMed Central
Google Scholar
Uddin MS, Kabir MT, Al Mamun A, Abdel-Daim MM, Barreto GE, Ashraf GM. APOE and Alzheimer’s disease: evidence mounts that targeting APOE4 may combat Alzheimer’s pathogenesis. Mol Neurobiol. 2019;56(4):2450–65.
Article
CAS
PubMed
Google Scholar
Gao X, Starmer J, Martin ER. A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms. Genet Epidemiol. 2008;32(4):361–9.
Article
PubMed
Google Scholar
Zou H, Hastie T. Regularization and variable selection via the elastic net. J R Stat Soc Series B Stat Methodology. 2005;67(2):301–20.
Article
Google Scholar
Ahrens A, Hansen CB, Schaffer ME. lassopack: Model selection and prediction with regularized regression in Stata. Stata J. 2020;20(1):176–235.
Article
Google Scholar
Windham BG, Parker SB, Zhu X, Gabriel KP, Palta P, Sullivan KJ, et al. Endurance and gait speed relationships with mild cognitive impairment and dementia. Alzheimers Dement (Amst). 2022;14(1):e12281.
Google Scholar
Toledo JB, Arnold M, Kastenmuller G, Chang R, Baillie RA, Han X, et al. Metabolic network failures in Alzheimer's disease: A biochemical road map. Alzheimers Dement. 2017;13(9):965–84.
Article
PubMed
PubMed Central
Google Scholar
Polis B, Samson AO. Role of the metabolism of branched-chain amino acids in the development of Alzheimer's disease and other metabolic disorders. Neural Regen Res. 2020;15(8):1460–70.
Article
PubMed
PubMed Central
Google Scholar
Suzuki H, Yamashiro D, Ogawa S, Kobayashi M, Cho D, Iizuka A, et al. Intake of Seven Essential Amino Acids Improves Cognitive Function and Psychological and Social Function in Middle-Aged and Older Adults: A Double-Blind, Randomized, Placebo-Controlled Trial. Front Nutr. 2020;7:586166.
Article
PubMed
PubMed Central
CAS
Google Scholar
Butterfield DA, Halliwell B. Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. Nat Rev Neurosci. 2019;20(3):148–60.
Article
CAS
PubMed
Google Scholar
Yao J, Brinton RD. Estrogen regulation of mitochondrial bioenergetics: implications for prevention of Alzheimer's disease. Adv Pharmacol. 2012;64:327–71.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jensen NJ, Wodschow HZ, Nilsson M, Rungby J. Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases. Int J Mol Sci. 2020;21(22):8767.
Domingues R, Pereira C, Cruz MT, Silva A. Therapies for Alzheimer's disease: a metabolic perspective. Mol Genet Metab. 2021;132(3):162–72.
Article
CAS
PubMed
Google Scholar
de Leeuw FA, Karamujic-Comic H, Tijms BM, Peeters CFW, Kester MI, Scheltens P, et al. Circulating metabolites are associated with brain atrophy and white matter hyperintensities. Alzheimers Dement. 2021;17(2):205–14.
Article
PubMed
CAS
Google Scholar
Salminen A, Haapasalo A, Kauppinen A, Kaarniranta K, Soininen H, Hiltunen M. Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape. Prog Neurobiol. 2015;131:1–20.
Article
CAS
PubMed
Google Scholar
Teo E, Ravi S, Barardo D, Kim HS, Fong S, Cazenave-Gassiot A, et al. Metabolic stress is a primary pathogenic event in transgenic Caenorhabditis elegans expressing pan-neuronal human amyloid beta. Elife. 2019;8:e50069.
van der Lee SJ, Teunissen CE, Pool R, Shipley MJ, Teumer A, Chouraki V, et al. Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies. Alzheimers Dement. 2018;14(6):707–22.
Article
PubMed
Google Scholar
Pedrini S, Hone E, Gupta VB, James I, Teimouri E, Bush AI, et al. Plasma High Density Lipoprotein Small Subclass is Reduced in Alzheimer's Disease Patients and Correlates with Cognitive Performance. J Alzheimers Dis. 2020;77(2):733–44.
Article
CAS
PubMed
PubMed Central
Google Scholar
Martinez AE, Weissberger G, Kuklenyik Z, He X, Meuret C, Parekh T, et al. The small HDL particle hypothesis of Alzheimer's disease. Alzheimers Dement. 2022;10.1002/alz.12649.
Chernick D, Zhong R, Li L. The Role of HDL and HDL Mimetic Peptides as Potential Therapeutics for Alzheimer's Disease. Biomolecules. 2020;10(9):1276.
Proitsi P, Kim M, Whiley L, Simmons A, Sattlecker M, Velayudhan L, et al. Association of blood lipids with Alzheimer's disease: A comprehensive lipidomics analysis. Alzheimers Dement. 2017;13(2):140–51.
Article
PubMed
Google Scholar
Hosseini M, Poljak A, Braidy N, Crawford J, Sachdev P. Blood fatty acids in Alzheimer's disease and mild cognitive impairment: A meta-analysis and systematic review. Ageing Res Rev. 2020;60:101043.
Article
CAS
PubMed
Google Scholar
Schilling S, Tzourio C, Soumare A, Kaffashian S, Dartigues JF, Ancelin ML, et al. Differential associations of plasma lipids with incident dementia and dementia subtypes in the 3C Study: A longitudinal, population-based prospective cohort study. PLoS Med. 2017;14(3):e1002265.
Article
PubMed
PubMed Central
CAS
Google Scholar
Ancelin ML, Ripoche E, Dupuy AM, Barberger-Gateau P, Auriacombe S, Rouaud O, et al. Sex differences in the associations between lipid levels and incident dementia. J Alzheimers Dis. 2013;34(2):519–28.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhu Y, Liu X, Zhu R, Zhao J, Wang Q. Lipid levels and the risk of dementia: A dose-response meta-analysis of prospective cohort studies. Ann Clin Transl Neurol. 2022;9(3):296–311.
Article
CAS
PubMed
PubMed Central
Google Scholar
Benn M, Nordestgaard BG, Frikke-Schmidt R, Tybjaerg-Hansen A. Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer's disease and Parkinson's disease: Mendelian randomisation study. BMJ. 2017;357:j1648.
Article
PubMed
PubMed Central
Google Scholar
Bernath MM, Bhattacharyya S, Nho K, Barupal DK, Fiehn O, Baillie R, et al. Serum triglycerides in Alzheimer disease: Relation to neuroimaging and CSF biomarkers. Neurology. 2020;94(20):e2088–98.
Article
CAS
PubMed
PubMed Central
Google Scholar
Janssen CI, Kiliaan AJ. Long-chain polyunsaturated fatty acids (LCPUFA) from genesis to senescence: the influence of LCPUFA on neural development, aging, and neurodegeneration. Prog Lipid Res. 2014;53:1–17.
Article
CAS
PubMed
Google Scholar
Julkunen H, Cichonska A, Slagboom PE, Wurtz P. Nightingale Health UKBI: Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population. Elife. 2021;10:e63033.
Petermann-Rocha F, Lyall DM, Gray SR, Esteban-Cornejo I, Quinn TJ, Ho FK, et al. Associations between physical frailty and dementia incidence: a prospective study from UK Biobank. Lancet Healthy Longevity. 2020;1(2):e58–68.
Article
Google Scholar
Wilkinson T, Schnier C, Bush K, Rannikmae K, Henshall DE, Lerpiniere C, et al. Identifying dementia outcomes in UK Biobank: a validation study of primary care, hospital admissions and mortality data. Eur J Epidemiol. 2019;34(6):557–65.
Article
PubMed
PubMed Central
Google Scholar
Zhang H, Greenwood DC, Risch HA, Bunce D, Hardie LJ, Cade JE. Meat consumption and risk of incident dementia: cohort study of 493,888 UK Biobank participants. Am J Clin Nutr. 2021;114(1):175–84.
Article
PubMed
PubMed Central
Google Scholar