Cohen JB, Cohen DL, Herman DS, Leppert JT, Byrd JB, Bhalla V. Testing for primary aldosteronism and mineralocorticoid receptor antagonist use among U.S. veterans : a retrospective cohort study. Ann Intern Med. 2021;174(3):289–97.
Article
Google Scholar
Carey RM, Sakhuja S, Calhoun DA, Whelton PK, Muntner P. Prevalence of apparent treatment-resistant hypertension in the United States. Hypertension. 2019;73(2):424–31.
Article
CAS
Google Scholar
Wu C, Wang Y, Zhang W, Li X, Wang L, Hui R. Prevalence and characteristics of apparent treatment-resistant hypertension in older people in China: a cross-sectional study. Clin Exp Hypertens. 2019;41(8):753–8.
Article
Google Scholar
Consortium G. The GTEx Consortium atlas of genetic regulatory effects across human tissues. Science. 2020;369(6509):1318–30.
Article
Google Scholar
Li H, Pei F, Shao L, Chen J, Sun K, Zhang X, et al. Prevalence and risk factors of abnormal left ventricular geometrical patterns in untreated hypertensive patients. BMC cardiovascular disorders. 2014;14(1):1–7.
Yan Y, Wang J, Yu L, Cui B, Wang H, Xiao X, et al. ANKRD36 is involved in hypertension by altering expression of ENaC genes. Circ Res. 2021;129(11):1067–81.
Article
CAS
Google Scholar
Cui B, Xiao X, Wang J, Wang H, Wu C, Yan Y, et al. Low THRB (thyroid hormone receptor beta) promoter methylation levels in peripheral blood leukocytes induced by systematic inflammation are involved in low thyroid hormone function in metabolic syndrome. Hypertension. 2021;78(4):1005–15.
Article
CAS
Google Scholar
Chang CC, Chow CC, Tellier LC, Vattikuti S, Purcell SM, Lee JJ. Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience. 2015;4(1):s13742-13015-10047-13748.
Article
Google Scholar
Anderson CA, Pettersson FH, Clarke GM, Cardon LR, Morris AP, Zondervan KT. Data quality control in genetic case-control association studies. Nat Protoc. 2010;5(9):1564–73.
Article
CAS
Google Scholar
Lemieux Perreault L-P, Legault M-A, Asselin G, Dube M-P. Genipe: an automated genome-wide imputation pipeline with automatic reporting and statistical tools. Bioinformatics. 2016;32(23):3661–3.
Google Scholar
Delaneau O, Marchini J. Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel. Nature communications. 2014;5(1):1–9.
Cingolani P, Platts A, Wang LL, Coon M, Nguyen T, Wang L, et al. A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3. Fly. 2012;6(2):80–92.
Article
CAS
Google Scholar
Pruim RJ, Welch RP, Sanna S, Teslovich TM, Chines PS, Gliedt TP, et al. LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics. 2010;26(18):2336–7.
Article
CAS
Google Scholar
Boughton AP, Welch RP, Flickinger M, VandeHaar P, Taliun D, Abecasis GR, et al. LocusZoom. js: interactive and embeddable visualization of genetic association study results. Bioinformatics. 2021;37(18):3017–8.
Article
CAS
Google Scholar
Bulik-Sullivan BK, Loh P-R, Finucane HK, Ripke S, Yang J, Patterson N, et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet. 2015;47(3):291–5.
Article
CAS
Google Scholar
Zheng J, Erzurumluoglu AM, Elsworth BL, Kemp JP, Howe L, Haycock PC, et al. LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis. Bioinformatics. 2017;33(2):272–9.
Article
CAS
Google Scholar
Wang L, Lv Q, He Y, Gu R, Zhou B, Chen J, et al. Integrated qPCR and staining methods for detection and quantification of Enterocytozoon hepatopenaei in Shrimp Litopenaeus vannamei. Microorganisms. 2020;8(9):1366.
Padmanabhan S, Caulfield M, Dominiczak AF. Genetic and molecular aspects of hypertension. Circ Res. 2015;116(6):937–59.
Article
CAS
Google Scholar
Padmanabhan S, Dominiczak AF. Genomics of hypertension: the road to precision medicine. Nat Rev Cardiol. 2021;18(4):235–50.
Article
CAS
Google Scholar
Studies ICfBPG-WA. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011;478(7367):103.
Article
Google Scholar
Tegegne BS, Man T, van Roon AM, Asefa NG, Riese H, Nolte I, et al. Heritability and the genetic correlation of heart rate variability and blood pressure in> 29 000 families: the Lifelines Cohort Study. Hypertension. 2020;76(4):1256–62.
Article
CAS
Google Scholar
Irvin MR, Sitlani CM, Floyd JS, Psaty BM, Bis JC, Wiggins KL, et al. Genome-wide association study of apparent treatment-resistant hypertension in the CHARGE consortium: the CHARGE pharmacogenetics working group. Am J Hypertens. 2019;32(12):1146–53.
Jhuo S-J, Tsai W-C, Lee H-C, Lin T-H, Lee K-T, Lai W-TJG. Association between adiponectin T94G polymorphism and resistant hypertension in young-onset Taiwanese patients. Gene. 2019;689:161–5.
Gong Y, McDonough CW, Beitelshees AL, El Rouby N, Hiltunen TP, O’Connell JR, et al. PTPRD gene associated with blood pressure response to atenolol and resistant hypertension. J Hypertens. 2015;33(11):2278.
Dumitrescu L, Ritchie MD, Denny JC, El Rouby NM, McDonough CW, Bradford Y, et al. Genome-wide study of resistant hypertension identified from electronic health records. PloS one. 2017;12(2):e0171745.
El Rouby N, McDonough CW, Gong Y, McClure LA, Mitchell BD, Horenstein RB, et al. Genome-wide association analysis of common genetic variants of resistant hypertension. Pharmacogenomics J. 2019;19(3):295–304.
Takahashi Y, Yamazaki K, Kamatani Y, Kubo M, Matsuda K, Asai S. A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population. Sci Rep. 2021;11(1):1–11.
Fontana V, McDonough CW, Gong Y, El Rouby NM, Sá ACC, Taylor KD, et al. Large-scale gene-centric analysis identifies polymorphisms for resistant hypertension. J Am Heart Assoc. 2014;3(6):e001398.
Kerimov N, Hayhurst JD, Peikova K, Manning JR, Walter P, Kolberg L, et al. eQTL Catalogue: a compendium of uniformly processed human gene expression and splicing QTLs. Nat Genetics. 2021; 53(9):1290-9.
D’Antonio M, Nguyen JP, Arthur TD, Matsui H, D’Antonio-Chronowska A, Frazer KA, et al. SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues. Cell Rep. 2021;37(7):110020.
Article
Google Scholar
Zhao L, Wang S, Xu M, He Y, Zhang X, Xiong Y, et al. Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages. Nat Commun. 2021;12(1):1–14.
Li T, Wang W, Gan W, Lv S, Zeng Z, Hou Y, et al. Comprehensive bioinformatics analysis identifies LAPTM5 as a potential blood biomarker for hypertensive patients with left ventricular hypertrophy. Aging (Albany NY). 2022;14(3):1508.
Article
CAS
Google Scholar
Xu X, Grijalva A, Skowronski A, van Eijk M, Serlie MJ, Ferrante AW Jr. Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation. Cell Metab. 2013;18(6):816–30.
Article
CAS
Google Scholar
Hochberg I, Harvey I, Tran QT, Stephenson EJ, Barkan AL, Saltiel AR, et al. Gene expression changes in subcutaneous adipose tissue due to Cushing’s disease. J Mol Endocrinol. 2015;55(2):81.
Article
CAS
Google Scholar
Barbier O, Torra IP, Sirvent A, Claudel T, Blanquart C, Duran-Sandoval D, et al. FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity. Gastroenterology. 2003;124(7):1926–40.
Article
CAS
Google Scholar
Kondoh N, Wakatsuki T, Ryo A, Hada A, Aihara T, Horiuchi S, et al. Identification and characterization of genes associated with human hepatocellular carcinogenesis. Cancer Res. 1999;59(19):4990–6.
CAS
Google Scholar
Chang BC-C, Hwang L-C, Huang W-H. Positive association of metabolic syndrome with a single nucleotide polymorphism of Syndecan-3 (rs2282440) in the Taiwanese population. Int J Endocrinol. 2018;2018.
Reizes O, Lincecum J, Wang Z, Goldberger O, Huang L, Kaksonen M, et al. Transgenic expression of syndecan-1 uncovers a physiological control of feeding behavior by syndecan-3. Cell. 2001;106(1):105–16.
Strader AD, Reizes O, Woods SC, Benoit SC, Seeley RJ. Mice lacking the syndecan-3 gene are resistant to diet-induced obesity. J Clin Investig. 2004;114(9):1354–60.
Article
CAS
Google Scholar
Dodoo SN, Benjamin IJ. Genomic approaches to hypertension. Cardiol Clin. 2017;35(2):185–96.
Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, et al. Eight blood pressure loci identified by genome-wide association study of 34,433 people of European ancestry. Nat Genet. 2009;41(6):666.
Martin-Lorenzo M, Martinez PJ, Baldan-Martin M, Ruiz-Hurtado G, Prado JC, Segura J, et al. Citric acid metabolism in resistant hypertension: underlying mechanisms and metabolic prediction of treatment response. Hypertension. 2017;70(5):1049–56.
Cao N, Tang H, Tian M, Gong X, Xu Z, Zhou B, et al. Genetic variants of GRK4 influence circadian rhythm of blood pressure and response to candesartan in hypertensive patients. Clin Exp Hypertens. 2021;43(7):597–603.
Takeuchi F, Isono M, Katsuya T, Yamamoto K, Yokota M, Sugiyama T, et al. Blood pressure and hypertension are associated with 7 loci in the Japanese population. Circulation. 2010;121(21):2302–9.
Tapia-Castillo A, Carvajal CA, López-Cortés X, Vecchiola A, Fardella CE. Novel metabolomic profile of subjects with non-classic apparent mineralocorticoid excess. Scientif Rep. 2021;11(1):1–12.
Kyoung J, Atluri RR, Yang TJH. Resistance to antihypertensive drugs: is gut microbiota the missing link? Hypertension. 2022;79(10): 2138-47.
Givens RC, Lin YS, Dowling AL, Thummel KE, Lamba JK, Schuetz EG, et al. CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults. J Appl Physiol. 2003;95(3):1297–300.
Ho H, Pinto A, Hall SD, Flockhart DA, Li L, Skaar TC, et al. Association between the CYP3A5 genotype and blood pressure. Hypertension. 2005;45(2):294–8.
Makris A, Seferou M, Papadopoulos DP. Resistant hypertension workup and approach to treatment. Int J Hypertens. 2010;2011.