Thoits PA. Mechanisms linking social ties and support to physical and mental health. J Health Soc Behav. 2011;52(2):145–61.
Cohen S, Wills TA. Stress, social support, and the buffering hypothesis. Psychol Bull. 1985;98(2):310–57.
Field RJ, Schuldberg D. Social-support moderated stress: a nonlinear dynamical model and the stress-buffering hypothesis. Nonlinear Dynamics Psychol Life Sci. 2011;15(1):53–85.
Hornstein EA, Eisenberger NI. Unpacking the buffering effect of social support figures: social support attenuates fear acquisition. PLoS One. 2017;12(5):e0175891.
Verner G, Epel E, Lahti-Pulkkinen M, Kajantie E, Buss C, Lin J, et al. Maternal psychological resilience during pregnancy and newborn telomere length: a prospective study. Am J Psychiatry. 2021;178(2):183–92.
Katzow M, Messito MJ, Mendelsohn AL, Scott MA, Gross RS. The Protective effect of prenatal social support on infant adiposity in the first 18 months of life. J Pediatr. 2019;209:77–84.
Uchino BN. Understanding the links between social support and physical health: a life-span perspective with emphasis on the separability of perceived and received support. Perspect Psychol Sci. 2009;4(3):236–55.
Rondinone O, Murgia A, Costanza J, Tabano S, Camanni M, Corsaro L, et al. Extensive placental methylation profiling in normal pregnancies. Int J Mol Sci. 2021;22(4):2136.
Novakovic B, Yuen RK, Gordon L, Penaherrera MS, Sharkey A, Moffett A, et al. Evidence for widespread changes in promoter methylation profile in human placenta in response to increasing gestational age and environmental/stochastic factors. BMC Genomics. 2011;12:529.
Ryan J, Mansell T, Fransquet P, Saffery R. Does maternal mental well-being in pregnancy impact the early human epigenome? Epigenomics. 2017;9(3):313–32.
Surkan PJ, Hong X, Zhang B, Nawa N, Ji H, Tang WY, et al. Can social support during pregnancy affect maternal DNA methylation? Findings from a cohort of African-Americans. Pediatr Res. 2020;88(1):131–8.
Massart R, Suderman MJ, Nemoda Z, Sutti S, Ruggiero AM, Dettmer AM, et al. The signature of maternal social rank in placenta deoxyribonucleic acid methylation profiles in rhesus monkeys. Child Dev. 2017;88(3):900–18.
Uchino BN, Trettevik R, Kent de Grey RG, Cronan S, Hogan J, Baucom BRW. Social support, social integration, and inflammatory cytokines: a meta-analysis. Health Psychol. 2018;37(5):462–71.
Ross KM, Miller G, Qadir S, Keenan-Devlin L, Leigh AKK, Borders A. Close relationship qualities and maternal peripheral inflammation during pregnancy. Psychoneuroendocrinology. 2017;77:252–60.
Ross KM, Thomas JC, Letourneau NL, Campbell TS, Giesbrecht GF. Partner social support during pregnancy and the postpartum period and inflammation in 3-month-old infants. Biol Psychol. 2019;144:11–9.
Grewal J, Grantz KL, Zhang C, Sciscione A, Wing DA, Grobman WA, et al. Cohort Profile: NICHD fetal growth studies-singletons and twins. Int J Epidemiol. 2018;47(1):25-l.
Inkster AM, Yuan V, Konwar C, Matthews AM, Brown CJ, Robinson WP. A cross-cohort analysis of autosomal DNA methylation sex differences in the term placenta. Biol Sex Differ. 2021;12(1):38.
Chatterjee S, Zeng X, Ouidir M, Tesfaye M, Zhang C, Tekola-Ayele F. Sex-specific placental gene expression signatures of small for gestational age at birth. Placenta. 2022;121:82–90.
Andrews SV, Yang IJ, Froehlich K, Oskotsky T, Sirota M. Large-scale placenta DNA methylation integrated analysis reveals fetal sex-specific differentially methylated CpG sites and regions. Sci Rep. 2022;12(1):9396.
Tekola-Ayele F, Workalemahu T, Gorfu G, Shrestha D, Tycko B, Wapner R, et al. Sex differences in the associations of placental epigenetic aging with fetal growth. Aging (Albany NY). 2019;11(15):5412–32.
Tesfaye M, Chatterjee S, Zeng X, Joseph P, Tekola-Ayele F. Impact of depression and stress on placental DNA methylation in ethnically diverse pregnant women. Epigenomics. 2021;13(18):1485–96.
Xu R, Hong X, Zhang B, Huang W, Hou W, Wang G, et al. DNA methylation mediates the effect of maternal smoking on offspring birthweight: a birth cohort study of multi-ethnic US mother-newborn pairs. Clin Epigenetics. 2021;13(1):47.
Vaglio J Jr, Conard M, Poston WS, O'Keefe J, Haddock CK, House J, et al. Testing the performance of the ENRICHD Social Support Instrument in cardiac patients. Health Qual Life Outcomes. 2004;2:24.
Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav. 1983;24(4):385–96.
Delahaye F, Do C, Kong Y, Ashkar R, Salas M, Tycko B, et al. Genetic variants influence on the placenta regulatory landscape. PLoS Genet. 2018;14(11):e1007785.
Shrestha D, Ouidir M, Workalemahu T, Zeng X, Tekola-Ayele F. Placental DNA methylation changes associated with maternal prepregnancy BMI and gestational weight gain. Int J Obes. 2020;44(6):1406–16.
Teschendorff AE, Marabita F, Lechner M, Bartlett T, Tegner J, Gomez-Cabrero D, et al. A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data. Bioinformatics. 2013;29(2):189–96.
Du P, Zhang X, Huang CC, Jafari N, Kibbe WA, Hou L, et al. Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis. BMC Bioinformatics. 2010;11:587.
Leek JT, Johnson WE, Parker HS, Jaffe AE, Storey JD. The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics. 2012;28(6):882–3.
Yuan V, Hui D, Yin Y, Penaherrera MS, Beristain AG, Robinson WP. Cell-specific characterization of the placental methylome. BMC Genomics. 2021;22(1):6.
van Iterson M, van Zwet EW, Consortium B, Heijmans BT. Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution. Genome Biol. 2017;18(1):19.
Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, et al. Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet. 2013;9(6):e1003500.
Matthew Suderman JRS, French R, Arathimos R, Simpkin A, Tilling K. dmrff: identifying differentially methylated regions efficiently with power and controlbioRxiv; 2018.
Breeze CE, Paul DS, van Dongen J, Butcher LM, Ambrose JC, Barrett JE, et al. eFORGE: a tool for identifying cell type-specific signal in epigenomic data. Cell Rep. 2016;17(8):2137–50.
Tekola-Ayele F, Zeng X, Ouidir M, Workalemahu T, Zhang C, Delahaye F, et al. DNA methylation loci in placenta associated with birthweight and expression of genes relevant for early development and adult diseases. Clin Epigenetics. 2020;12(1):78.
Mitchell PH, Powell L, Blumenthal J, Norten J, Ironson G, Pitula CR, et al. A short social support measure for patients recovering from myocardial infarction: the ENRICHD Social Support Inventory. J Cardpulm Rehabil. 2003;23(6):398–403.
Grobman WA, Parker C, Wadhwa PD, Willinger M, Simhan H, Silver B, et al. Racial/ethnic disparities in measures of self-reported psychosocial states and traits during pregnancy. Am J Perinatol. 2016;33(14):1426–32.
Nordin M, Nordin S. Psychometric evaluation and normative data of the Swedish version of the 10-item perceived stress scale. Scand J Psychol. 2013;54(6):502–7.
Mizoguchi T, Minakuchi H, Ishisaka M, Tsuruma K, Shimazawa M, Hara H. Behavioral abnormalities with disruption of brain structure in mice overexpressing VGF. Sci Rep. 2017;7(1):4691.
Lewis JE, Brameld JM, Jethwa PH. Neuroendocrine role for VGF. Front Endocrinol (Lausanne). 2015;6:3.
Kitamura T, Seki N, Kihara A. Phytosphingosine degradation pathway includes fatty acid alpha-oxidation reactions in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2017;114(13):E2616–E23.
Gaudet P, Livstone MS, Lewis SE, Thomas PD. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011;12(5):449–62.
Brait M, Maldonado L, Noordhuis MG, Begum S, Loyo M, Poeta ML, et al. Association of promoter methylation of VGF and PGP9.5 with ovarian cancer progression. PLoS One. 2013;8(9):e70878.
Marwitz S, Heinbockel L, Scheufele S, Nitschkowski D, Kugler C, Perner S, et al. Epigenetic modifications of the VGF gene in human non-small cell lung cancer tissues pave the way towards enhanced expression. Clin Epigenetics. 2017;9:123.
Jiang Z, Wang H, Li L, Hou Z, Liu W, Zhou T, et al. Analysis of TGCA data reveals genetic and epigenetic changes and biological function of MUC family genes in colorectal cancer. Future Oncol. 2019;15(35):4031–43.
Lin S, Zhang Y, Hu Y, Yang B, Cui J, Huang J, et al. Epigenetic downregulation of MUC17 by H. pylori infection facilitates NF-kappaB-mediated expression of CEACAM1-3S in human gastric cancer. Gastric Cancer. 2019;22(5):941–54.
Shallie PD, Naicker T. The placenta as a window to the brain: a review on the role of placental markers in prenatal programming of neurodevelopment. Int J Dev Neurosci. 2019;73:41–9.
Nkansah-Amankra S, Dhawain A, Hussey JR, Luchok KJ. Maternal social support and neighborhood income inequality as predictors of low birth weight and preterm birth outcome disparities: analysis of South Carolina Pregnancy Risk Assessment and Monitoring System survey, 2000-2003. Matern Child Health J. 2010;14(5):774–85.
Lee HY, Oh J, Perkins JM, Heo J, Subramanian SV. Associations between maternal social capital and infant birth weight in three developing countries: a cross-sectional multilevel analysis of Young Lives data. BMJ Open. 2019;9(10):e024769.
Paredes Mondragon CV, Molano Dorado H, Martinez Gomez SY, Ortiz Martinez RA, Arias Linthon S, Lopez Benavides AC. Relationship between the absence of adequate social support during pregnancy and low birth weight. Rev Colomb Psiquiatr (Engl Ed). 2019;48(3):140–8.
Wado YD, Afework MF, Hindin MJ. Effects of maternal pregnancy intention, depressive symptoms and social support on risk of low birth weight: a prospective study from southwestern Ethiopia. PLoS One. 2014;9(5):e96304.
Zou Y, Tong HJ, Li M, Tan KS, Cao T. Telomere length is regulated by FGF-2 in human embryonic stem cells and affects the life span of its differentiated progenies. Biogerontology. 2017;18(1):69–84.
Zhang Q, Liu N, Bai J, Zhou Q, Mao J, Xu L, et al. Human telomerase reverse transcriptase is a novel target of Hippo-YAP pathway. FASEB J. 2020;34(3):4178–88.
Hammoudeh SM, Hammoudeh AM, Bhamidimarri PM, Al Safar H, Mahboub B, Kunstner A, et al. Systems immunology analysis reveals the contribution of pulmonary and extrapulmonary tissues to the immunopathogenesis of severe COVID-19 patients. Front Immunol. 2021;12:595150.
Schneider H, Berger E, Dolan B, Martinez-Abad B, Arike L, Pelaseyed T, et al. The human transmembrane mucin MUC17 responds to TNFalpha by increased presentation at the plasma membrane. Biochem J. 2019;476(16):2281–95.
Rohleder N. Stimulation of systemic low-grade inflammation by psychosocial stress. Psychosom Med. 2014;76(3):181–9.
Rosenfeld CS. The placenta-brain-axis. J Neurosci Res. 2021;99(1):271–83.
Hwang I, Pan H, Yao J, Elemento O, Zheng H, Paik J. CIC is a critical regulator of neuronal differentiation. JCI. Insight. 2020;5(9):e135826. https://doi.org/10.1172/jci.insight.135826.
Jiang C, Lin WJ, Sadahiro M, Labonte B, Menard C, Pfau ML, et al. VGF function in depression and antidepressant efficacy. Mol Psychiatry. 2018;23(7):1632–42.
Lin WJ, Jiang C, Sadahiro M, Bozdagi O, Vulchanova L, Alberini CM, et al. VGF and its C-terminal peptide TLQP-62 regulate memory formation in hippocampus via a BDNF-TrkB-dependent mechanism. J Neurosci. 2015;35(28):10343–56.
Lin WJ, Zhao Y, Li Z, Zheng S, Zou JL, Warren NA, et al. An increase in VGF expression through a rapid, transcription-independent, autofeedback mechanism improves cognitive function. Transl Psychiatry. 2021;11(1):383.
Quinn JP, Kandigian SE, Trombetta BA, Arnold SE, Carlyle BC. VGF as a biomarker and therapeutic target in neurodegenerative and psychiatric diseases. Brain Commun. 2021;3(4):fcab261.
Foglesong GD, Huang W, Liu X, Slater AM, Siu J, Yildiz V, et al. Role of hypothalamic VGF in energy balance and metabolic adaption to environmental enrichment in mice. Endocrinology. 2016;157(3):983–96.
Lewis JE, Brameld JM, Hill P, Cocco C, Noli B, Ferri GL, et al. Hypothalamic over-expression of VGF in the Siberian hamster increases energy expenditure and reduces body weight gain. PLoS One. 2017;12(2):e0172724.
Dunn GA, Morgan CP, Bale TL. Sex-specificity in transgenerational epigenetic programming. Horm Behav. 2011;59(3):290–5.
Gabory A, Attig L, Junien C. Sexual dimorphism in environmental epigenetic programming. Mol Cell Endocrinol. 2009;304(1-2):8–18.
Monk C, Feng T, Lee S, Krupska I, Champagne FA, Tycko B. Distress during pregnancy: epigenetic regulation of placenta glucocorticoid-related genes and fetal neurobehavior. Am J Psychiatry. 2016;173(7):705–13.
Marzi SJ, Sugden K, Arseneault L, Belsky DW, Burrage J, Corcoran DL, et al. Analysis of DNA methylation in young people: limited evidence for an association between victimization stress and epigenetic variation in blood. Am J Psychiatry. 2018;175(6):517–29.
Rodevand L, Bahrami S, Frei O, Lin A, Gani O, Shadrin A, et al. Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms. Transl Psychiatry. 2021;11(1):3.
NCBI. Genetic variants influence on the placenta regulatory landscape. NCBI: database of Genotypes and Phenotypes. https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001717.v1.p1 (2019).