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  1. A global plan has been set to end human deaths from dog-mediated rabies by 2030 ("Zero-by-30"), but whether it could be achieved in some countries, such as China, remains unclear. Although elimination strategi...

    Authors: Qiulan Chen, Qiuping Liu, Chao Gong, Wenwu Yin, Di Mu, Yu Li, Shujun Ding, Yifang Liu, Hao Yang, Shuwu Zhou, Sa Chen, Zhongfa Tao, Yanping Zhang and Xun Tang
    Citation: BMC Medicine 2023 21:100
  2. Metabolomic changes during pregnancy have been suggested to underlie the etiology of gestational diabetes mellitus (GDM). However, research on metabolites during preconception is lacking. Therefore, this study...

    Authors: Ling-Jun Li, Ximeng Wang, Yap Seng Chong, Jerry Kok Yen Chan, Kok Hian Tan, Johan G. Eriksson, Zhongwei Huang, Mohammad L. Rahman, Liang Cui and Cuilin Zhang
    Citation: BMC Medicine 2023 21:99
  3. Hepatitis B virus (HBV) core protein-targeting antivirals (CpTAs) are promising therapeutic agents for treating chronic hepatitis B (CHB). In this study, the antiviral activity, pharmacokinetics (PK), and tole...

    Authors: Haiyan Jia, Jiajia Mai, Min Wu, Hong Chen, Xiaojiao Li, Cuiyun Li, Jingrui Liu, Chengjiao Liu, Yue Hu, Xiaoxue Zhu, Xiuhong Jiang, Bo Hua, Tian Xia, Gang Liu, Aiyun Deng, Bo Liang…
    Citation: BMC Medicine 2023 21:98
  4. Understanding the overall effectiveness of non-pharmaceutical interventions to control the COVID-19 pandemic and reduce the burden of disease is crucial for future pandemic planning. However, quantifying the e...

    Authors: Rachael Pung, Hannah E. Clapham, Timothy W. Russell, Vernon J. Lee and Adam J. Kucharski
    Citation: BMC Medicine 2023 21:97
  5. Extracellular vesicles (EVs) derived from bone marrow mesenchymal stem cells (MSCs) pretreated with atorvastatin (ATV) (MSCATV-EV) have a superior cardiac repair effect on acute myocardial infarction (AMI). The m...

    Authors: Yu Ning, Peisen Huang, Guihao Chen, Yuyan Xiong, Zhaoting Gong, Chunxiao Wu, Junyan Xu, Wenyang Jiang, Xiaosong Li, Ruijie Tang, Lili Zhang, Mengjin Hu, Jing Xu, Jun Xu, Haiyan Qian, Chen Jin…
    Citation: BMC Medicine 2023 21:96
  6. While epidemiological studies have found correlations between light at night (LAN) and health effects, none has so far investigated the impacts of LAN on population mortality yet. We aimed to estimate the rela...

    Authors: Yao Lu, Peng Yin, Jie Wang, Yiping Yang, Fei Li, Hong Yuan, Shenxin Li, Zheng Long and Maigeng Zhou
    Citation: BMC Medicine 2023 21:95
  7. Previous studies have shown that monotherapy with apatinib, an oral tyrosine kinase inhibitor, has promising efficacy for treating recurrent or metastatic (RM) nasopharyngeal carcinoma (NPC) patients. In this ...

    Authors: Lin-Quan Tang, Xiao-Yun Li, Zhi-Ming Li, Zhi-Gang Liu, Miao-Zhen Lin, Huan Zhou, Qi-Wen Yu, Jian Zhou, Chong Zhao, Ze-Bin Chen, Xi-Cheng Wang, Jia-Yu Peng, Qiu-Yan Chen, Wen-Feng Fang, Yun-Peng Yang, Bei Zhang…
    Citation: BMC Medicine 2023 21:94
  8. Mitochondrial transplantation (MTx) is an emerging but poorly understood technology with the potential to mitigate severe ischemia–reperfusion injuries after cardiac arrest (CA). To address critical gaps in th...

    Authors: Kei Hayashida, Ryosuke Takegawa, Yusuke Endo, Tai Yin, Rishabh C. Choudhary, Tomoaki Aoki, Mitsuaki Nishikimi, Atsushi Murao, Eriko Nakamura, Muhammad Shoaib, Cyrus Kuschner, Santiago J. Miyara, Junhwan Kim, Koichiro Shinozaki, Ping Wang and Lance B. Becker
    Citation: BMC Medicine 2023 21:56
  9. The identification of effective dementia prevention strategies is a major public health priority, due to the enormous and growing societal cost of this condition. Consumption of a Mediterranean diet (MedDiet) ...

    Authors: Oliver M. Shannon, Janice M. Ranson, Sarah Gregory, Helen Macpherson, Catherine Milte, Marleen Lentjes, Angela Mulligan, Claire McEvoy, Alex Griffiths, Jamie Matu, Tom R. Hill, Ashley Adamson, Mario Siervo, Anne Marie Minihane, Graciela Muniz-Tererra, Craig Ritchie…
    Citation: BMC Medicine 2023 21:81
  10. Childhood maltreatment is associated with depression and cardiometabolic disease in adulthood. However, the relationships with these two diseases have so far only been evaluated in different samples and with d...

    Authors: Camille Souama, Femke Lamers, Yuri Milaneschi, Christiaan H. Vinkers, Serena Defina, Linda Garvert, Frederike Stein, Tom Woofenden, Katharina Brosch, Udo Dannlowski, Henrike Galenkamp, Ron de Graaf, Vincent W. V. Jaddoe, Anja Lok, Bas B. van Rijn, Henry Völzke…
    Citation: BMC Medicine 2023 21:93
  11. Preterm premature rupture of membranes (PPROM), which is associated with vaginal dysbiosis, is responsible for up to one-third of all preterm births. Consecutive ascending colonization, infection, and inflamma...

    Authors: Luiz Gustavo dos Anjos Borges, Jana Pastuschek, Yvonne Heimann, Kristin Dawczynski, Ekkehard Schleußner, Dietmar H. Pieper and Janine Zöllkau
    Citation: BMC Medicine 2023 21:92
  12. Social prescribing (SP) usually involves linking patients in primary care with services provided by the voluntary and community sector. Preliminary evidence suggests that SP may offer a means of connecting pat...

    Authors: Sara Calderón-Larrañaga, Trish Greenhalgh, Megan Clinch, John Robson, Isabel Dostal, Fabiola Eto and Sarah Finer
    Citation: BMC Medicine 2023 21:91
  13. Pre-eclampsia (PE) is one of the leading causes of maternal and fetal morbidity/mortality during pregnancy, and alpha-2-macroglobulin (A2M) is associated with inflammatory signaling; however, the pathophysiolo...

    Authors: Jingyun Wang, Ping Zhang, Mengyuan Liu, Zhengrui Huang, Xiaofeng Yang, Yuzhen Ding, Jia Liu, Xin Cheng, Shujie Xu, Meiyao He, Fengxiang Zhang, Guang Wang, Ruiman Li and Xuesong Yang
    Citation: BMC Medicine 2023 21:90
  14. Understanding the effects of risk factor burden and genetic predisposition on the long-term risk of atrial fibrillation (AF) is important to improve public health initiatives. However, the 10-year risk of AF c...

    Authors: Junguo Zhang, Ge Chen, ChongJian Wang, Xiaojie Wang, Zhengmin (Min) Qian, Miao Cai, Michael G. Vaughn, Elizabeth Bingheim, Haitao Li, Yanhui Gao, Gregory Y. H. Lip and Hualiang Lin
    Citation: BMC Medicine 2023 21:88
  15. Overall survival (OS) is the gold standard endpoint to assess treatment efficacy in cancer clinical trials. In metastatic breast cancer (mBC), progression-free survival (PFS) is commonly used as an intermediat...

    Authors: Coralie Courtinard, Sophie Gourgou, William Jacot, Matthieu Carton, Olivier Guérin, Laure Vacher, Aurélie Bertaut, Marie-Cécile Le Deley, David Pérol, Patricia Marino, Christelle Levy, Lionel Uwer, Geneviève Perrocheau, Renaud Schiappa, Florence Bachelot, Damien Parent…
    Citation: BMC Medicine 2023 21:87
  16. A Phase II study was undertaken to evaluate the safety and efficacy of the neoadjuvant socazolimab, a novel PD-L1 inhibitor, in combination with nab-paclitaxel and cisplatin for locally advanced esophageal squ...

    Authors: Yong Li, Aiping Zhou, Shuoyan Liu, Ming He, Keneng Chen, Ziqiang Tian, Yin Li, Jianjun Qin, Zhen Wang, Haiquan Chen, Hui Tian, Yue Yu, Wang Qu, Liyan Xue, Shun He, Shuhang Wang…
    Citation: BMC Medicine 2023 21:86
  17. The COVID-19 vaccine supply shortage in 2021 constrained roll-out efforts in Africa while populations experienced waves of epidemics. As supply improves, a key question is whether vaccination remains an impact...

    Authors: Yang Liu, Simon R. Procter, Carl A. B. Pearson, Andrés Madriz Montero, Sergio Torres-Rueda, Elias Asfaw, Benjamin Uzochukwu, Tom Drake, Eleanor Bergren, Rosalind M. Eggo, Francis Ruiz, Nicaise Ndembi, Justice Nonvignon, Mark Jit and Anna Vassall
    Citation: BMC Medicine 2023 21:85
  18. Micronutrients play an essential role at every stage of the immune response, and deficiencies can therefore lead to increased susceptibility to infections. Previous observational studies and randomized control...

    Authors: Helene M. Flatby, Anuradha Ravi, Jan K. Damås, Erik Solligård and Tormod Rogne
    Citation: BMC Medicine 2023 21:84
  19. Several studies on long-term air pollution exposure and sleep have reported inconsistent results. Large-scale studies on short-term air pollution exposures and sleep have not been conducted. We investigated th...

    Authors: Peining Zhou, Jing Ma, Xueying Li, Yixue Zhao, Kunyao Yu, Rui Su, Rui Zhou, Hui Wang and Guangfa Wang
    Citation: BMC Medicine 2023 21:83
  20. Water intake and hydration status have been suggested to impact cognition; however, longitudinal evidence is limited and often inconsistent. This study aimed to longitudinally assess the association between hy...

    Authors: Stephanie K. Nishi, Nancy Babio, Indira Paz-Graniel, Lluís Serra-Majem, Jesús Vioque, Montserrat Fitó, Dolores Corella, Xavier Pintó, Aurora Bueno-Cavanillas, Josep A. Tur, Laura Diez-Ricote, J. Alfredo Martinez, Carlos Gómez-Martínez, Andrés González-Botella, Olga Castañer, Andrea Alvarez-Sala…
    Citation: BMC Medicine 2023 21:82
  21. The complexity of sleep hinders the formulation of sleep guidelines. Recent studies suggest that different unhealthy sleep characteristics jointly increase the risks for cardiovascular disease (CVD). This stud...

    Authors: Bo-Huei Huang, Borja del Pozo Cruz, Armando Teixeira-Pinto, Peter A. Cistulli and Emmanuel Stamatakis
    Citation: BMC Medicine 2023 21:75
  22. Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investiga...

    Authors: Joseph A. Rothwell, Jelena Bešević, Niki Dimou, Marie Breeur, Neil Murphy, Mazda Jenab, Roland Wedekind, Vivian Viallon, Pietro Ferrari, David Achaintre, Audrey Gicquiau, Sabina Rinaldi, Augustin Scalbert, Inge Huybrechts, Cornelia Prehn, Jerzy Adamski…
    Citation: BMC Medicine 2023 21:80
  23. Anti-Müllerian hormone (AMH) is released by testicular Sertoli cells and of great importance during fetal male sexual development, but less is known about the role of circulating AMH during adulthood. In vitro...

    Authors: Rune Holt, Sam Kafai Yahyavi, Ireen Kooij, Christine Hjorth Andreassen, Anna-Maria Andersson, Anders Juul, Niels Jørgensen and Martin Blomberg Jensen
    Citation: BMC Medicine 2023 21:79
  24. Both BNT162b2 (Pfizer–BioNTech) and ChAdOx1 nCoV-19 (Oxford–AstraZeneca) vaccines have shown high efficacy against COVID-19 in randomized controlled trials. However, their comparative effectiveness against COV...

    Authors: Jie Wei, Weiya Zhang, Michael Doherty, Zachary S. Wallace, Jeffrey A. Sparks, Na Lu, Xiaoxiao Li, Chao Zeng, Guanghua Lei and Yuqing Zhang
    Citation: BMC Medicine 2023 21:78
  25. Heterozygous familial hypercholesterolemia (HeFH) is largely underdiagnosed and undertreated in China where few patients achieved recommended target levels of low density lipoprotein cholesterol (LDL-C). We co...

    Authors: Meng Chai, Yongming He, Wang Zhao, Xuebin Han, Guoyan Zhao, Xueping Ma, Ping Qiao, Dongmei Shi, Yuyang Liu, Wei Han, Pei An, Haoyu Li, Shuling Yan, Qingyang Ma, Huan Deng, Lei Qian…
    Citation: BMC Medicine 2023 21:77
  26. The role of systemic inflammation in promoting cardiovascular diseases has attracted attention, but its correlation with various arrhythmias remains to be clarified. We aimed to comprehensively assess the asso...

    Authors: Xiaorong Yang, Shaohua Zhao, Shaohua Wang, Xuelei Cao, Yue Xu, Meichen Yan, Mingmin Pang, Fan Yi and Hao Wang
    Citation: BMC Medicine 2023 21:76
  27. Comorbidities among cancer survivors remain a serious healthcare burden and require appropriate management. Using two widely used frailty indicators, this study aimed to evaluate whether frailty was associated...

    Authors: Xingqi Cao, Zhenqing Yang, Xueqin Li, Chen Chen, Emiel O. Hoogendijk, Jingyun Zhang, Nengliang Aaron Yao, Lina Ma, Yawei Zhang, Yong Zhu, Xuehong Zhang, Yuxian Du, Xiaofeng Wang, Xifeng Wu, Thomas M. Gill and Zuyun Liu
    Citation: BMC Medicine 2023 21:74
  28. Compound epidermal growth factor receptor (EGFR) mutations are less responsive to tyrosine kinase inhibitors (TKIs) than single EGFR mutations in non-small cell lung cancer (NSCLC). However, the detailed clinical...

    Authors: Weixin Zhao, Ailing Song, Yang Xu, Qian Wu, Cuicui Liu, Jiani C. Yin, Qiuxiang Ou, Xue Wu, Yang Shao and Xinmin Zhao
    Citation: BMC Medicine 2023 21:73
  29. Iruplinalkib (WX-0593) is an anaplastic lymphoma kinase (ALK)/c-ros oncogene 1 (ROS1) tyrosine kinase inhibitor. Here we reported the single-arm, phase II study (INTELLECT) results of the efficacy and safety o...

    Authors: Yuankai Shi, Jianhua Chen, Helong Zhang, Zhihong Zhang, Yiping Zhang, Zhehai Wang, Shucai Zhang, Jian Zhao, Chunling Liu, Xiuwen Wang, Yanqiu Zhao, Changlu Hu, Lei Yang, Xuezhi Hao, Lin Wang, Yunpeng Liu…
    Citation: BMC Medicine 2023 21:72
  30. No study evaluated the incidence of intra-stent restenosis (ISR)-related events in patients with type 2 diabetes (T2DM) and acute myocardial infarction (AMI) treated or not with sodium/glucose cotransporter 2 ...

    Authors: Raffaele Marfella, Celestino Sardu, Nunzia D’Onofrio, Carlo Fumagalli, Lucia Scisciola, Ferdinando Carlo Sasso, Mario Siniscalchi, Ludovica Vittoria Marfella, Davide D’Andrea, Fabio Minicucci, Giuseppe Signoriello, Arturo Cesaro, Maria Consiglia Trotta, Chiara Frigé, Francesco Prattichizzo, Maria Luisa Balestrieri…
    Citation: BMC Medicine 2023 21:71
  31. Clinical prediction models should be validated before implementation in clinical practice. But is favorable performance at internal validation or one external validation sufficient to claim that a prediction m...

    Authors: Ben Van Calster, Ewout W. Steyerberg, Laure Wynants and Maarten van Smeden
    Citation: BMC Medicine 2023 21:70
  32. Redundant clinical trials waste resources and unnecessarily put patients at risk for harm. The objectives of the study were to assess redundant randomized clinical trials (RCTs) conducted in mainland China or ...

    Authors: Yuanxi Jia, Jun Liang, Wenyao Wang, Xin Wei, Shaoming Xiao and Karen A. Robinson
    Citation: BMC Medicine 2023 21:69
  33. Castration-resistant prostate cancer often metastasizes to the bone, and such bone metastases eventually become resistant to available therapies, leading to the death of patients. Enriched in the bone, TGF-β p...

    Authors: Qingqing Huang, Mingcheng Liu, Duo Zhang, Bing-Biao Lin, Xing Fu, Zhiqian Zhang, Baotong Zhang and Jin-Tang Dong
    Citation: BMC Medicine 2023 21:68
  34. Evidence linking air pollution to major depressive disorder (MDD) remains sparse and results are heterogeneous. In addition, the evidence about the interaction and joint associations of genetic risk and lifest...

    Authors: Dankang Li, Junqing Xie, Lulin Wang, Yu Sun, Yonghua Hu and Yaohua Tian
    Citation: BMC Medicine 2023 21:67
  35. Evidence from observational studies and clinical trials suggests that the gut microbiota is associated with cancer. However, the causal association between gut microbiota and cancer remains to be determined.

    Authors: Yiwen Long, Lanhua Tang, Yangying Zhou, Shushan Zhao and Hong Zhu
    Citation: BMC Medicine 2023 21:66
  36. Current prognostic prediction models of colorectal cancer (CRC) include only the preoperative measurement of tumor markers, with their available repeated postoperative measurements underutilized. CRC prognosti...

    Authors: Chunxia Li, Ke Zhao, Dafu Zhang, Xiaolin Pang, Hongjiang Pu, Ming Lei, Bingbing Fan, Jiali Lv, Dingyun You, Zhenhui Li and Tao Zhang
    Citation: BMC Medicine 2023 21:63
  37. After ischemic stroke (IS), peripheral leukocytes infiltrate the damaged region and modulate the response to injury. Peripheral blood cells display distinctive gene expression signatures post-IS and these tran...

    Authors: Paulina Carmona-Mora, Bodie Knepp, Glen C. Jickling, Xinhua Zhan, Marisa Hakoupian, Heather Hull, Noor Alomar, Hajar Amini, Frank R. Sharp, Boryana Stamova and Bradley P. Ander
    Citation: BMC Medicine 2023 21:65
  38. To assess the association between the reproductive factors of age at menarche, age at menopause, and reproductive span and the incidence of myocardial infarction (MI) and ischemic stroke (IS).

    Authors: Su-Min Jeong, Jung Eun Yoo, Keun Hye Jeon, Kyungdo Han, Heesun Lee, Dong-Yun Lee and Dong Wook Shin
    Citation: BMC Medicine 2023 21:64
  39. Recent studies found associations between non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS), but the causal nature of this association is still uncertain.

    Authors: Dong Liu, Xue Gao, Xiong-Fei Pan, Tao Zhou, Cairong Zhu, Fei Li, Jian-Gao Fan, Giovanni Targher and Jian Zhao
    Citation: BMC Medicine 2023 21:62
  40. The relations of the variety and quantity of different sources of dietary insoluble fibers and hypertension remain uncertain. We aimed to investigate the associations between the variety and quantity of insolu...

    Authors: Ziliang Ye, Qimeng Wu, Sisi Yang, Yanjun Zhang, Chun Zhou, Mengyi Liu, Zhuxian Zhang, Panpan He, Yuanyuan Zhang, Rui Li, Huan Li, Chengzhang Liu, Jing Nie, Fan Fan Hou and Xianhui Qin
    Citation: BMC Medicine 2023 21:61
  41. Maternal hypertensive disorders during pregnancy (HDP) have been suggested to contribute to the development of offspring cardiovascular disease later in life, but empirical evidence remains inconsistent. This ...

    Authors: Liu Yang, Chen Huang, Min Zhao, Priscilla M. Y. Lee, Cheng Zhang, Yongfu Yu, Bo Xi and Jiong Li
    Citation: BMC Medicine 2023 21:59
  42. Naming a newly discovered disease is a difficult process; in the context of the COVID-19 pandemic and the existence of post-acute sequelae of SARS-CoV-2 infection (PASC), which includes long COVID, it has prov...

    Authors: Emily R. Pfaff, Charisse Madlock-Brown, John M. Baratta, Abhishek Bhatia, Hannah Davis, Andrew Girvin, Elaine Hill, Elizabeth Kelly, Kristin Kostka, Johanna Loomba, Julie A. McMurry, Rachel Wong, Tellen D. Bennett, Richard Moffitt, Christopher G. Chute and Melissa Haendel
    Citation: BMC Medicine 2023 21:58
  43. An extensive body of animal literature supports the premise that maternal obesity during pregnancy can alter the development of the fetal hypothalamus (HTH, a critical regulator of energy balance) with implica...

    Authors: Jerod M. Rasmussen, Jetro J. Tuulari, Saara Nolvi, Paul M. Thompson, Harri Merisaari, Maria Lavonius, Linnea Karlsson, Sonja Entringer, Pathik D. Wadhwa, Hasse Karlsson and Claudia Buss
    Citation: BMC Medicine 2023 21:57
  44. Rheumatoid arthritis (RA) is a chronic inflammatory disease that is associated with joint pain and stiffness. Biologics represent some of the most effective treatments for RA, but previous guidance from the Na...

    Authors: Peter C. Taylor, Ayman Askari, Ernest Choy, Michael R. Ehrenstein, Sara Else and Muhammad K. Nisar
    Citation: BMC Medicine 2023 21:55
  45. Recent studies have reported that the associations between dietary carbohydrates and cardiovascular disease (CVD) may depend on the quality, rather than the quantity, of carbohydrates consumed. This study aime...

    Authors: Rebecca K. Kelly, Tammy Y. N. Tong, Cody Z. Watling, Andrew Reynolds, Carmen Piernas, Julie A. Schmidt, Keren Papier, Jennifer L. Carter, Timothy J. Key and Aurora Perez-Cornago
    Citation: BMC Medicine 2023 21:34