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  1. Prednisolone has been suggested as a treatment for olfactory disorders after COVID-19, but evidence is scarce. Hence, we aimed to determine the efficacy of a short oral prednisolone treatment on patients with ...

    Authors: Emma J. A. Schepens, Esther E. Blijleven, Wilbert M. Boek, Sanne Boesveldt, Robert J. Stokroos, Inge Stegeman and Digna M. A. Kamalski
    Citation: BMC Medicine 2022 20:445
  2. There is growing evidence that patients recovering after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may have a variety of acute sequelae including newly diagnosed diabetes. Howeve...

    Authors: Ting Zhang, Qimin Mei, Zhaocai Zhang, Joseph Harold Walline, Yecheng Liu, Huadong Zhu and Shuyang Zhang
    Citation: BMC Medicine 2022 20:444
  3. Several recent observational studies have reported that gut microbiota composition is associated with preeclampsia. However, the causal effect of gut microbiota on preeclampsia-eclampsia is unknown.

    Authors: Pengsheng Li, Haiyan Wang, Lan Guo, Xiaoyan Gou, Gengdong Chen, Dongxin Lin, Dazhi Fan, Xiaoling Guo and Zhengping Liu
    Citation: BMC Medicine 2022 20:443
  4. The SARS-CoV-2 containment strategy has been successful in mainland China prior to the emergence of Omicron. However, in the era of highly transmissible variants, whether it is possible for China to sustain a ...

    Authors: Yan Wang, Kaiyuan Sun, Zhaomin Feng, Lan Yi, Yanpeng Wu, Hengcong Liu, Quanyi Wang, Marco Ajelli, Cécile Viboud and Hongjie Yu
    Citation: BMC Medicine 2022 20:442
  5. Low-density Plasmodium falciparum infections prevail in low transmission settings, where immunity is expected to be minimal, suggesting an immune-independent effect on parasite densities. We aimed to describe par...

    Authors: Glória Matambisso, Nanna Brokhattingen, Sónia Maculuve, Pau Cisteró, Henriques Mbeve, Anna Escoda, Judice Miguel, Elena Buetas, Ianthe de Jong, Boaventura Cuna, Cardoso Melembe, Nelo Ndimande, Gemma Porras, Haily Chen, Kevin K. A. Tetteh, Chris Drakeley…
    Citation: BMC Medicine 2022 20:396
  6. Aggressive lipid lowering by high-dose statin treatment has been established for the secondary prevention of coronary artery disease (CAD). Regarding the low-density lipoprotein cholesterol (LDL-C) level, howe...

    Authors: Masashi Sakuma, Satoshi Iimuro, Tomohiro Shinozaki, Takeshi Kimura, Yoshihisa Nakagawa, Yukio Ozaki, Hiroshi Iwata, Katsumi Miyauchi, Hiroyuki Daida, Satoru Suwa, Ichiro Sakuma, Yosuke Nishihata, Yasushi Saito, Hisao Ogawa, Masunori Matsuzaki, Yasuo Ohashi…
    Citation: BMC Medicine 2022 20:441
  7. Tuberculosis remains a major public health priority and is the second leading cause of mortality from infectious disease worldwide. TB case detection rates are unacceptably low for men, the elderly and childre...

    Authors: C. Finn McQuaid, Marc Y. R. Henrion, Rachael M. Burke, Peter MacPherson, Rebecca Nzawa-Soko and Katherine C. Horton
    Citation: BMC Medicine 2022 20:432
  8. Due to the blood-brain barrier, plasma is not an ideal source to evaluate the genetic characteristics of central nervous system tumors. Thus, cerebrospinal fluid (CSF) is becoming an alternative biopsy type to...

    Authors: Meichen Li, Jing Chen, Baishen Zhang, Juan Yu, Na Wang, Delan Li, Yang Shao, Dongqin Zhu, Chuqiao Liang, Yutong Ma, Qiuxiang Ou, Xue Hou and Likun Chen
    Citation: BMC Medicine 2022 20:398

    The Correction to this article has been published in BMC Medicine 2023 21:15

  9. Untreated celiac disease (CD) patients have increased levels of blood glutamine and a lower duodenal expression of glutaminase (GLS). Intestinal gluconeogenesis (IGN) is a process through which glutamine is tu...

    Authors: Olof Karlson, Henrik Arnell, Audur H. Gudjonsdottir, Daniel Agardh and Åsa Torinsson Naluai
    Citation: BMC Medicine 2022 20:440
  10. The effect of frailty and poor cardiovascular health on mortality for males and females is not fully elucidated. We investigated whether the combined burden of frailty and poor cardiovascular health is associa...

    Authors: Jack Quach, Olga Theou, Judith Godin, Kenneth Rockwood and Dustin Scott Kehler
    Citation: BMC Medicine 2022 20:394
  11. Individuals with a family history of colorectal cancer (CRC) are at a high risk of developing CRC. Preclinical studies suggest that the anti-malaria drug proguanil and atovaquone might play a role in preventin...

    Authors: Naiqi Zhang, Jan Sundquist, Kristina Sundquist and Jianguang Ji
    Citation: BMC Medicine 2022 20:439
  12. Myotonic dystrophy type 1 (DM1) is an incurable multisystem disease caused by a CTG-repeat expansion in the DM1 protein kinase (DMPK) gene. The OPTIMISTIC clinical trial demonstrated positive and heterogenous eff...

    Authors: Remco T. P. van Cruchten, Daniël van As, Jeffrey C. Glennon, Baziel G. M. van Engelen and Peter A. C. ‘t Hoen
    Citation: BMC Medicine 2022 20:395
  13. Risk profiles for premature cardiovascular disease (CVD) are unclear. This study aimed to examine baseline risk profiles for incident CVD by age at onset in Chinese population.

    Authors: Xue Tian, Shuohua Chen, Yingting Zuo, Yijun Zhang, Xiaoli Zhang, Qin Xu, Yanxia Luo, Shouling Wu and Anxin Wang
    Citation: BMC Medicine 2022 20:383
  14. Various stakeholders are calling for increased availability of data and code from cancer research. However, it is unclear how commonly these products are shared, and what factors are associated with sharing. O...

    Authors: Daniel G. Hamilton, Matthew J. Page, Sue Finch, Sarah Everitt and Fiona Fidler
    Citation: BMC Medicine 2022 20:438
  15. Cervical squamous cell carcinoma (SCC) is known to arise through increasingly higher-grade squamous intraepithelial lesions (SILs) or cervical intraepithelial neoplasias (CINs). This study aimed to describe se...

    Authors: Jianwei Zhang, Silu Meng, Xiaoyan Wang, Jun Wang, Xinran Fan, Haiying Sun, Ruoqi Ning, Bing Xiao, Xiangqin Li, Yao Jia, Dongli Kong, Ruqi Chen, Changyu Wang, Ding Ma and Shuang Li
    Citation: BMC Medicine 2022 20:437
  16. A major hand-foot-and-mouth disease (HFMD) pathogen, coxsackievirus A16 (CVA16), has predominated in several of the last 10 years and caused the largest number of HFMD outbreaks between 2011 and 2018 in China....

    Authors: Jiaxin Zhou, Yonghong Zhou, Kaiwei Luo, Qiaohong Liao, Wen Zheng, Hui Gong, Huilin Shi, Shanlu Zhao, Kai Wang, Qi Qiu, Bingbing Dai, Lingshuang Ren, Lili Wang, Lidong Gao, Meng Xu, Nuolan Liu…
    Citation: BMC Medicine 2022 20:436
  17. Although immune checkpoint inhibitors (ICIs) have influenced the treatment paradigm for multiple solid tumors, increasing evidence suggests that primary and adaptive resistance may limit the long-term efficacy...

    Authors: Pei Zhang, Yang Du, Hua Bai, Zhijie Wang, Jianchun Duan, Xin Wang, Jia Zhong, Rui Wan, Jiachen Xu, Xiran He, Di Wang, Kailun Fei, Ruofei Yu, Jie Tian and Jie Wang
    Citation: BMC Medicine 2022 20:435
  18. Human papillomavirus (HPV) vaccination and intensifying screening expedite cervical cancer (CC) elimination, yet also deteriorate the balance between harms and benefits of screening. We aimed to find screening...

    Authors: Erik E. L. Jansen, Inge M. C. M. de Kok, Sylvia Kaljouw, Erhan Demirel, Harry J. de Koning and Jan. A. C. Hontelez
    Citation: BMC Medicine 2022 20:433
  19. Non-alcoholic fatty liver disease (NAFLD) can lead to pulmonary dysfunction that is associated with pulmonary inflammation. Moreover, little is known regarding the therapeutic role of exercise training on pulm...

    Authors: Jinkyung Cho, Bruce D. Johnson, Kymberly D. Watt, Alexander S. Niven, Dongwook Yeo and Chul-Ho Kim
    Citation: BMC Medicine 2022 20:429
  20. The empirical evidence remains inconclusive for an association between diabetes mellitus (DM) in children and early-onset kidney disease later in life, and little is known about the effects of DM types (i.e., ...

    Authors: Jiahong Sun, Ce Wang, Min Zhao, Priscilla M. Y. Lee, Bo Xi, Yongfu Yu and Jiong Li
    Citation: BMC Medicine 2022 20:428
  21. The influence of maternal levothyroxine treatment during pregnancy remains unclear. This study aimed to evaluate the associations of maternal levothyroxine treatment during pregnancy with the birth and neurode...

    Authors: Grace Mengqin Ge, Edmund C. L. Cheung, Kenneth K. C. Man, Patrick Ip, Wing Cheong Leung, Gloria H. Y. Li, Annie W. C. Kung, Ching-Lung Cheung and Ian C. K. Wong
    Citation: BMC Medicine 2022 20:390
  22. Currently, immunotherapy is widely used in the treatment of various stages of non-small cell lung cancer. According to clinical experience and results of previous studies, immunotherapy as neoadjuvant therapy ...

    Authors: Yimin Wang, Chuling Li, Zimu Wang, Zhaofeng Wang, Ranpu Wu, Ying Wu, Yong Song and Hongbing Liu
    Citation: BMC Medicine 2022 20:426
  23. The COVID-19 pandemic has highlighted the importance of evidence-based clinical decision-making. Clinical management guidelines (CMGs) may help reduce morbidity and mortality by improving the quality of clinic...

    Authors: Ishmeala Rigby, Melina Michelen, Vincent Cheng, Andrew Dagens, Dania Dahmash, Samuel Lipworth, Eli Harriss, Erhui Cai, Valeria Balan, Alexandra Oti, Reena Joseph, Helen Groves, Peter Hart, Shevin Jacob, Lucille Blumberg, Peter W. Horby…
    Citation: BMC Medicine 2022 20:425
  24. Language deficits frequently occur during the prodromal stages of Alzheimer’s disease (AD). However, the characteristics of linguistic impairment and its underlying mechanism(s) remain to be explored for the e...

    Authors: Hua-Long Wang, Ran Tang, Ru-Jing Ren, Eric B. Dammer, Qi-Hao Guo, Guo-Ping Peng, Hai-Lun Cui, You-Min Zhang, Jin-Tao Wang, Xin-Yi Xie, Qiang Huang, Jian-Ping Li, Fu-Hua Yan, Sheng-Di Chen, Na-Ying He and Gang Wang
    Citation: BMC Medicine 2022 20:380
  25. The Accelerating Innovation for Mothers (AIM) project established a database of candidate medicines in research and development (R&D) between 2000 and 2021 for five pregnancy-related conditions, including pre-...

    Authors: Annie R. A. McDougall, Roxanne Hastie, Maya Goldstein, Andrew Tuttle, Stephen Tong, Anne Ammerdorffer, A. Metin Gülmezoglu and Joshua P. Vogel
    Citation: BMC Medicine 2022 20:393
  26. Gestational age (GA) is associated with later cognition and behavior. However, it is unclear how specific cognitive domains and brain structural development varies with the stepwise change of gestational durat...

    Authors: Qing Ma, Hui Wang, Edmund T. Rolls, Shitong Xiang, Jiong Li, Yuzhu Li, Qiongjie Zhou, Wei Cheng and Fei Li
    Citation: BMC Medicine 2022 20:424
  27. Oral mucositis (OM) in patients receiving cancer therapy is thus far not well managed with standard approaches. We aimed to assess the safety and effectiveness of methylene blue (MB) oral rinse for OM pain in ...

    Authors: Carlos J. Roldan, Billy Huh, Juhee Song, Yago Nieto, Joyce Osei, Thomas Chai, Kent Nouri, Lakshmi Koyyalagunta and Eduardo Bruera
    Citation: BMC Medicine 2022 20:377
  28. Obesity is a well-defined risk factor for heart failure with preserved ejection fraction (HFpEF), but it is associated with a better prognosis in patients with diagnosed HFpEF. The paradoxically poor prognosis...

    Authors: Bin Dong, Yiling Yao, Ruicong Xue, Weihao Liang, Jiangui He, Fangfei Wei, Yugang Dong, Xin He and Chen Liu
    Citation: BMC Medicine 2022 20:423
  29. Currently, there is limited evidence about the long-term impact on physical, social and emotional functioning, i.e. health-related quality of life (HRQL) after mild or moderate COVID-19 not requiring hospitali...

    Authors: Anouk Verveen, Elke Wynberg, Hugo D. G. van Willigen, Udi Davidovich, Anja Lok, Eric P. Moll van Charante, Menno D. de Jong, Godelieve de Bree, Maria Prins, Hans Knoop and Pythia T. Nieuwkerk
    Citation: BMC Medicine 2022 20:422
  30. Prophylactic antibiotic use during delivery is common in routine obstetric practice to prevent infection globally, especially in low- and middle-income countries. In China, however, little is currently known a...

    Authors: Qiguo Lian, Tao Zheng, Xiaona Huo, Jun Zhang and Lin Zhang
    Citation: BMC Medicine 2022 20:391
  31. Epidemiological studies have reported an association between amyotrophic lateral sclerosis (ALS) and different autoimmune disorders. This study aims to explore the causal relationship between autoimmune disord...

    Authors: Paria Alipour, Konstantin Senkevich, Jay P. Ross, Dan Spiegelman, Despoina Manousaki, Patrick A. Dion and Guy A. Rouleau
    Citation: BMC Medicine 2022 20:382
  32. Psoriasis has been linked to cardiovascular disease (CVD), including coronary artery disease (CAD), myocardial infarction (MI), and heart failure (HF). However, available studies regarding this relationship ha...

    Authors: Liming Zhang, Yuxiang Wang, Li Qiu and Jian Wu
    Citation: BMC Medicine 2022 20:421
  33. Multimorbidity (the presence of two or more chronic conditions) is common amongst people with chronic kidney disease, but it is unclear which conditions cluster together and if this changes as kidney function ...

    Authors: Michael K. Sullivan, Juan-Jesus Carrero, Bhautesh Dinesh Jani, Craig Anderson, Alex McConnachie, Peter Hanlon, Dorothea Nitsch, David A. McAllister, Frances S. Mair, Patrick B. Mark and Alessandro Gasparini
    Citation: BMC Medicine 2022 20:420
  34. Observational epidemiological studies suggest a link between several factors related to ovulation and reproductive function and endometrial cancer (EC) risk; however, it is not clear whether these relationship...

    Authors: Shannon D’Urso, Pooja Arumugam, Therese Weider, Liang-Dar Hwang, Tom A. Bond, John P. Kemp, Nicole M. Warrington, David M. Evans, Tracy A. O’Mara and Gunn-Helen Moen
    Citation: BMC Medicine 2022 20:419
  35. Multiple human pathogens establish chronic, sometimes life-long infections. Even if they are often latent, these infections can trigger some degree of local or systemic immune response, resulting in chronic lo...

    Authors: Flavia Hodel, Olivier Naret, Clara Bonnet, Nicole Brenner, Noemi Bender, Tim Waterboer, Pedro Marques-Vidal, Peter Vollenweider and Jacques Fellay
    Citation: BMC Medicine 2022 20:416
  36. Breastmilk is a dynamic fluid whose initial function is to provide the most adapted nutrition to the neonate. Additional attributes have been recently ascribed to breastmilk, with the evidence of a specific mi...

    Authors: Raúl Piñeiro-Salvador, Eduardo Vazquez-Garza, José Antonio Cruz-Cardenas, Cuauhtémoc Licona-Cassani, Gerardo García-Rivas, Jorge Moreno-Vásquez, Mario René Alcorta-García, Victor Javier Lara-Diaz and Marion E. G. Brunck
    Citation: BMC Medicine 2022 20:388
  37. The World Health Organization (WHO) has developed a costing tool, the Cervical Cancer Prevention and Control Costing (C4P) tool, to estimate the comprehensive cost of cervical cancer primary, secondary and ter...

    Authors: Ann Levin, Safina Yuma, Edwin Swai, Winthrop Morgan, Cindy L. Gauvreau, Nathalie Broutet, Karene Hoi Ting Yeung and Raymond Hutubessy
    Citation: BMC Medicine 2022 20:384
  38. Hepatic arterial infusion chemotherapy (HAIC) with oxaliplatin and 5-fluorouracil was effective in unresectable hepatocellular carcinoma (HCC). The program of FOLFOX-HAIC in HCC was performed for 1 day (HAIC 1...

    Authors: Zhicheng Lai, Yexing Huang, Dongsheng Wen, Xuanjia Lin, Anna Kan, Qijiong Li, Wei Wei, Minshan Chen, Li Xu, Minke He and Ming Shi
    Citation: BMC Medicine 2022 20:415
  39. The combination of oncolytic viruses (OVs) with immune checkpoint blockades is a research hotspot and has shown good efficacy. Here, we present the first attempt to combine oncolytic herpes simplex virus 2 (OH...

    Authors: Defeng Kong, Zhenrong Yang, Guoliang Li, Quanyou Wu, Zhaoru Gu, Duo Wan, Qi Zhang, Xiaoli Zhang, Shujun Cheng, Binlei Liu, Kaitai Zhang and Wen Zhang
    Citation: BMC Medicine 2022 20:376
  40. Though the association between air pollution and incident type 2 diabetes (T2D) has been well documented, evidence on the association with development of subsequent diabetes complications and post-diabetes mor...

    Authors: Yinglin Wu, Shiyu Zhang, Samantha E. Qian, Miao Cai, Haitao Li, Chongjian Wang, Hongtao Zou, Lan Chen, Michael G. Vaughn, Stephen Edward McMillin and Hualiang Lin
    Citation: BMC Medicine 2022 20:375
  41. Heavy drinking was well associated with an increased risk of hepatocellular carcinoma (HCC), whereas the effect of low-to-moderate drinking on HCC remains under debate.

    Authors: Zhenqiu Liu, Ci Song, Chen Suo, Hong Fan, Tiejun Zhang, Li Jin and Xingdong Chen
    Citation: BMC Medicine 2022 20:413
  42. The applicability of randomised controlled trials of pharmacological agents to older people with frailty/multimorbidity is often uncertain, due to concerns that trials are not representative. However, assessin...

    Authors: Peter Hanlon, Elaine Butterly, Anoop S. V. Shah, Laurie J. Hannigan, Sarah H. Wild, Bruce Guthrie, Frances S. Mair, Sofia Dias, Nicky J. Welton and David A. McAllister
    Citation: BMC Medicine 2022 20:410