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  1. COVID-19 poses one of the most profound public health crises for a hundred years. As of mid-May 2020, across the world, almost 300,000 deaths and over 4 million confirmed cases were registered. Reaching over 3...

    Authors: Mark D. Verhagen, David M. Brazel, Jennifer Beam Dowd, Ilya Kashnitsky and Melinda C. Mills

    Citation: BMC Medicine 2020 18:203

    Content type: Research article

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  2. Pancreatic cancer is refractory to most current treatment options. Immunotherapy emerges as an effective and novel therapeutic strategy for several solid tumors. However, most of the clinical trials on immunot...

    Authors: Courtney W. Houchen and Min Li

    Citation: BMC Medicine 2020 18:155

    Content type: Commentary

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  3. There is a clear need for systematic appraisal of models/factors predicting colorectal cancer (CRC) metastasis and recurrence because clinical decisions about adjuvant treatment are taken on the basis of such ...

    Authors: Wei Xu, Yazhou He, Yuming Wang, Xue Li, Jane Young, John P. A. Ioannidis, Malcolm G. Dunlop and Evropi Theodoratou

    Citation: BMC Medicine 2020 18:172

    Content type: Research article

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  4. Data from the UK COVID-19 outbreak are emerging, and there are ongoing concerns about a disproportionate effect on ethnic minorities. There is very limited information on COVID-19 in the over-80s, and the rate...

    Authors: Simon E. Brill, Hannah C. Jarvis, Ezgi Ozcan, Thomas L. P. Burns, Rabia A. Warraich, Lisa J. Amani, Amina Jaffer, Stephanie Paget, Anand Sivaramakrishnan and Dean D. Creer

    Citation: BMC Medicine 2020 18:194

    Content type: Research article

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  5. Current outbreaks of COVID-19 are threatening the health care systems of several countries around the world. Control measures, based on isolation, contact tracing, and quarantine, can decrease and delay the bu...

    Authors: Andrea Torneri, Pieter Libin, Joris Vanderlocht, Anne-Mieke Vandamme, Johan Neyts and Niel Hens

    Citation: BMC Medicine 2020 18:191

    Content type: Research article

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  6. Major infectious disease outbreaks are a constant threat to human health. Clinical research responses to outbreaks generate evidence to improve outcomes and outbreak control. Experiences from previous epidemic...

    Authors: Louise Sigfrid, Katherine Maskell, Peter G. Bannister, Sharif A. Ismail, Shelui Collinson, Sadie Regmi, Claire Blackmore, Eli Harriss, Kajsa-Stina Longuere, Nina Gobat, Peter Horby, Mike Clarke and Gail Carson

    Citation: BMC Medicine 2020 18:190

    Content type: Research article

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  7. There are no overviews of systematic reviews investigating haemoglobin thresholds for transfusion. This is important as the literature on transfusion thresholds has grown considerably in recent years. Our aim ...

    Authors: Kevin M. Trentino, Shannon L. Farmer, Michael F. Leahy, Frank M. Sanfilippo, James P. Isbister, Rhonda Mayberry, Axel Hofmann, Aryeh Shander, Craig French and Kevin Murray

    Citation: BMC Medicine 2020 18:154

    Content type: Research article

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  8. As in most eliminating countries, malaria transmission is highly focal in Haiti. More granular information, including identifying asymptomatic infections, is needed to inform programmatic efforts, monitor inte...

    Authors: Thomas Druetz, Gillian Stresman, Ruth A. Ashton, Lotus L. van den Hoogen, Vena Joseph, Carl Fayette, Frank Monestime, Karen E. Hamre, Michelle A. Chang, Jean F. Lemoine, Chris Drakeley and Thomas P. Eisele

    Citation: BMC Medicine 2020 18:141

    Content type: Research article

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  9. Glioblastoma (GBM) is one of the most aggressive and vascularized brain tumors in adults, with a median survival of 20.9 months. In newly diagnosed and recurrent GBM, bevacizumab demonstrated an increase in pr...

    Authors: N. García-Romero, I. Palacín-Aliana, R. Madurga, J. Carrión-Navarro, S. Esteban-Rubio, B. Jiménez, A. Collazo, F. Pérez-Rodríguez, A. Ortiz de Mendivil, C. Fernández-Carballal, S. García-Duque, J. Diamantopoulos-Fernández, C. Belda-Iniesta, R. Prat-Acín, P. Sánchez-Gómez, E. Calvo…

    Citation: BMC Medicine 2020 18:142

    Content type: Research article

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  10. Prion disease is neurodegenerative disease that is typically fatal within months of first symptoms. Clinical trials in this rapidly declining symptomatic patient population have proven challenging. Individuals...

    Authors: Sonia M. Vallabh, Eric Vallabh Minikel, Victoria J. Williams, Becky C. Carlyle, Alison J. McManus, Chase D. Wennick, Anna Bolling, Bianca A. Trombetta, David Urick, Chloe K. Nobuhara, Jessica Gerber, Holly Duddy, Ingolf Lachmann, Christiane Stehmann, Steven J. Collins, Kaj Blennow…

    Citation: BMC Medicine 2020 18:140

    Content type: Research article

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  11. A connection between amyotrophic lateral sclerosis (ALS) and altered gut microbiota composition has previously been reported in animal models. This work is the first prospective longitudinal study addressing t...

    Authors: Diana Di Gioia, Nicole Bozzi Cionci, Loredana Baffoni, Angela Amoruso, Marco Pane, Luca Mogna, Francesca Gaggìa, Maria Ausiliatrice Lucenti, Enrica Bersano, Roberto Cantello, Fabiola De Marchi and Letizia Mazzini

    Citation: BMC Medicine 2020 18:153

    Content type: Research article

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  12. PREDICT Prostate is an endorsed prognostic model that provides individualised long-term prostate cancer-specific and overall survival estimates. The model, derived from UK data, estimates potential treatment bene...

    Authors: David Thurtle, Ola Bratt, Pär Stattin, Paul Pharoah and Vincent Gnanapragasam

    Citation: BMC Medicine 2020 18:139

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2020 18:213

  13. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency state in humans. The clinical phenotype is variable and includes asymptomatic individuals, episodic hemolysis induced by...

    Authors: James J. Gilchrist, Sophie Uyoga, Matti Pirinen, Anna Rautanen, Salim Mwarumba, Patricia Njuguna, Neema Mturi, Adrian V. S. Hill, J. Anthony G. Scott and Thomas N. Williams

    Citation: BMC Medicine 2020 18:148

    Content type: Research article

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  14. Verbal autopsy is the main method used in countries with weak civil registration systems for estimating community causes of neonatal and 1–59-month-old deaths. However, validation studies of verbal autopsy met...

    Authors: Henry D. Kalter, Jamie Perin, Agbessi Amouzou, Gift Kwamdera, Wasilat Adeyinka Adewemimo, Félicitée Nguefack, Abdoulaye-Mamadou Roubanatou and Robert E. Black

    Citation: BMC Medicine 2020 18:183

    Content type: Research article

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  15. Child maltreatment is associated with cardiovascular disease (CVD), but mediation pathways have not been fully elucidated. The aim of the current study was to determine and quantify the underlying pathways lin...

    Authors: Frederick K. Ho, Carlos Celis-Morales, Stuart R. Gray, Fanny Petermann-Rocha, Donald Lyall, Daniel Mackay, Naveed Sattar, Helen Minnis and Jill P. Pell

    Citation: BMC Medicine 2020 18:143

    Content type: Research article

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  16. Severe iodine insufficiency in pregnancy has significant consequences, but there is inadequate evidence to indicate what constitutes mild or moderate insufficiency, in terms of observed detrimental effects on ...

    Authors: Charles Jonathan Peter Snart, Diane Erin Threapleton, Claire Keeble, Elizabeth Taylor, Dagmar Waiblinger, Stephen Reid, Nisreen A. Alwan, Dan Mason, Rafaq Azad, Janet Elizabeth Cade, Nigel A. B. Simpson, Sarah Meadows, Amanda McKillion, Gillian Santorelli, Amanda H. Waterman, Michael Zimmermann…

    Citation: BMC Medicine 2020 18:132

    Content type: Research article

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  17. Herd protection through interruption of transmission has contributed greatly to the impact of pneumococcal conjugate vaccines (PCVs) and may enable the use of cost-saving reduced dose schedules. To aid PCV age...

    Authors: Stefan Flasche, Marc Lipsitch, John Ojal and Amy Pinsent

    Citation: BMC Medicine 2020 18:129

    Content type: Research article

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  18. While a high body mass index (BMI) in midlife is associated with higher risk of dementia, high BMI in late-life may be associated with lower risk. This study combined genetic designs with longitudinal data to ...

    Authors: Ida K. Karlsson, Kelli Lehto, Margaret Gatz, Chandra A. Reynolds and Anna K. Dahl Aslan

    Citation: BMC Medicine 2020 18:131

    Content type: Research article

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  19. On January 30, COVID-19 was declared a Public Health Emergency of International Concern—a week after Singapore’s first imported case and 5 days before local transmission. The National University Hospital (NUH)...

    Authors: Sophia Archuleta, Gail Cross, Jyoti Somani, Lionel Lum, Amelia Santosa, Rawan A. Alagha, David M. Allen, Alicia Ang, Darius Beh, Louis Chai, Si Min Chan, See Ming Lim, Dariusz P. Olszyna, Catherine Ong, Jolene Oon, Brenda M. A. Salada…

    Citation: BMC Medicine 2020 18:179

    Content type: Correspondence

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  20. Randomised controlled trials (RCTs) need to be reported so that their results can be unambiguously and robustly interpreted. Binary outcomes yield unique challenges, as different analytical approaches may prod...

    Authors: Ines Rombach, Ruth Knight, Nicholas Peckham, Jamie R. Stokes and Jonathan A. Cook

    Citation: BMC Medicine 2020 18:147

    Content type: Research article

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  21. Antidepressant medication (ADM) and psychotherapy are effective treatments for major depressive disorder (MDD). It is unclear, however, if treatments differ in their effectiveness at the symptom level and whet...

    Authors: Nils Kappelmann, Martin Rein, Julia Fietz, Helen S. Mayberg, W. Edward Craighead, Boadie W. Dunlop, Charles B. Nemeroff, Martin Keller, Daniel N. Klein, Bruce A. Arnow, Nusrat Husain, Robin B. Jarrett, Jeffrey R. Vittengl, Marco Menchetti, Gordon Parker, Jacques P. Barber…

    Citation: BMC Medicine 2020 18:170

    Content type: Registered report

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  22. Accurate and noninvasive diagnosis and staging of liver fibrosis are essential for effective clinical management of chronic liver disease (CLD). We aimed to identify serum metabolite markers that reliably pred...

    Authors: Guoxiang Xie, Xiaoning Wang, Runmin Wei, Jingye Wang, Aihua Zhao, Tianlu Chen, Yixing Wang, Hua Zhang, Zhun Xiao, Xinzhu Liu, Youping Deng, Linda Wong, Cynthia Rajani, Sandi Kwee, Hua Bian, Xin Gao…

    Citation: BMC Medicine 2020 18:144

    Content type: Research article

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  23. The EXAMINE trial tested the efficacy and safety of alogliptin, an inhibitor of dipeptidyl peptidase 4, compared with placebo in 5380 patients with type 2 diabetes and a recent acute coronary syndrome. Because...

    Authors: João Pedro Ferreira, Cyrus Mehta, Abhinav Sharma, Steven E. Nissen, Patrick Rossignol and Faiez Zannad

    Citation: BMC Medicine 2020 18:165

    Content type: Research article

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  24. Chronic kidney disease (CKD) has an apparent sex disparity, with a more rapid progress in men than in women. Whether the well-established sex-specific evolutionary biology trade-off between reproduction and lo...

    Authors: Jie V. Zhao and C. Mary Schooling

    Citation: BMC Medicine 2020 18:122

    Content type: Research article

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  25. Coronavirus disease 2019 (COVID-19) has infected more than 4 million people within 4 months. There is an urgent need to properly identify high-risk cases that are more likely to deteriorate even if they presen...

    Authors: Jichan Shi, Yang Li, Xian Zhou, Qiran Zhang, Xinchun Ye, Zhengxing Wu, Xiangao Jiang, Hongying Yu, Lingyun Shao, Jing-Wen Ai, Haocheng Zhang, Bin Xu, Feng Sun and Wenhong Zhang

    Citation: BMC Medicine 2020 18:168

    Content type: Research article

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  26. As of March 31, 2020, the ongoing COVID-19 epidemic that started in China in December 2019 is now generating local transmission around the world. The geographic heterogeneity and associated intervention strate...

    Authors: Amna Tariq, Yiseul Lee, Kimberlyn Roosa, Seth Blumberg, Ping Yan, Stefan Ma and Gerardo Chowell

    Citation: BMC Medicine 2020 18:166

    Content type: Research article

    Published on:

    The Commentary to this article has been published in BMC Medicine 2020 18:164

  27. Malaria in pregnancy, including asymptomatic infection, has a detrimental impact on foetal development. Individual patient data (IPD) meta-analysis was conducted to compare the association between antimalarial...

    Authors: Makoto Saito, Rashid Mansoor, Kalynn Kennon, Anupkumar R. Anvikar, Elizabeth A. Ashley, Daniel Chandramohan, Lauren M. Cohee, Umberto D’Alessandro, Blaise Genton, Mary Ellen Gilder, Elizabeth Juma, Linda Kalilani-Phiri, Irene Kuepfer, Miriam K. Laufer, Khin Maung Lwin, Steven R. Meshnick…

    Citation: BMC Medicine 2020 18:138

    Content type: Research article

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  28. This article aims to summarize the key characteristics of registered trials of 2019 novel coronavirus (COVID-19), in terms of their spatial and temporal distributions, types of design and interventions, and pa...

    Authors: Liming Lu, Fan Li, Hao Wen, Shuqi Ge, Jingchun Zeng, Wen Luo, Lai Wang, Chunzhi Tang and Nenggui Xu

    Citation: BMC Medicine 2020 18:167

    Content type: Research article

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  29. Network meta-analyses using individual participant data (IPD-NMAs) have been increasingly used to compare the effects of multiple interventions. Although there have been many studies on statistical methods for...

    Authors: Ya Gao, Shuzhen Shi, Muyang Li, Xinyue Luo, Ming Liu, Kelu Yang, Junhua Zhang, Fujian Song and Jinhui Tian

    Citation: BMC Medicine 2020 18:120

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2020 18:156

  30. Understanding of the role of ethnicity and socioeconomic position in the risk of developing SARS-CoV-2 infection is limited. We investigated this in the UK Biobank study.

    Authors: Claire L. Niedzwiedz, Catherine A. O’Donnell, Bhautesh Dinesh Jani, Evangelia Demou, Frederick K. Ho, Carlos Celis-Morales, Barbara I. Nicholl, Frances S. Mair, Paul Welsh, Naveed Sattar, Jill P. Pell and S. Vittal Katikireddi

    Citation: BMC Medicine 2020 18:160

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2020 18:206

  31. Choosing or altering the planned statistical analysis approach after examination of trial data (often referred to as ‘p-hacking’) can bias the results of randomised trials. However, the extent of this issue in...

    Authors: Suzie Cro, Gordon Forbes, Nicholas A. Johnson and Brennan C. Kahan

    Citation: BMC Medicine 2020 18:137

    Content type: Research article

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  32. The five-tiered Cambridge Prognostic Group (CPG) classification is a better predictor of prostate cancer-specific mortality than the traditional three-tiered classification (low, intermediate, and high risk). ...

    Authors: M. G. Parry, T. E. Cowling, A. Sujenthiran, J. Nossiter, B. Berry, P. Cathcart, A. Aggarwal, H. Payne, J. van der Meulen, N. W. Clarke and V. J. Gnanapragasam

    Citation: BMC Medicine 2020 18:114

    Content type: Research article

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  33. Serum free thiols (R-SH, sulfhydryl groups) reliably reflect systemic oxidative stress. Since serum free thiols are rapidly oxidized by reactive species, systemic oxidative stress is generally associated with ...

    Authors: Amaal E. Abdulle, Arno R. Bourgonje, Lyanne M. Kieneker, Anne M. Koning, S. la Bastide-van Gemert, Marian L. C. Bulthuis, Gerard Dijkstra, Klaas Nico Faber, Robin P. F. Dullaart, Stephan J. L. Bakker, Reinold O. B. Gans, Ron T. Gansevoort, Douwe J. Mulder, Andreas Pasch and Harry van Goor

    Citation: BMC Medicine 2020 18:130

    Content type: Research article

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  34. Particulate matter exposure during in utero life may entail adverse health outcomes later in life. The microvasculature undergoes extensive, organ-specific prenatal maturation. A growing body of evidence shows th...

    Authors: Leen J. Luyten, Yinthe Dockx, Eline B. Provost, Narjes Madhloum, Hanne Sleurs, Kristof Y. Neven, Bram G. Janssen, Hannelore Bové, Florence Debacq-Chainiaux, Nele Gerrits, Wouter Lefebvre, Michelle Plusquin, Charlotte Vanpoucke, Patrick De Boever and Tim S. Nawrot

    Citation: BMC Medicine 2020 18:128

    Content type: Research article

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  35. Individuals with co-occurring hyperactivity disorder/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) can have complex presentations that may complicate diagnosis and treatment. There are estab...

    Authors: Susan Young, Jack Hollingdale, Michael Absoud, Patrick Bolton, Polly Branney, William Colley, Emily Craze, Mayuri Dave, Quinton Deeley, Emad Farrag, Gisli Gudjonsson, Peter Hill, Ho-lan Liang, Clodagh Murphy, Peri Mackintosh, Marianna Murin…

    Citation: BMC Medicine 2020 18:146

    Content type: Guideline

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