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  1. Malaria causes a reduction in haemoglobin that is compounded by primaquine, particularly in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. The aim of this study was to determine the relativ...

    Authors: Robert J. Commons, Julie A. Simpson, Kamala Thriemer, Cindy S. Chu, Nicholas M. Douglas, Tesfay Abreha, Sisay G. Alemu, Arletta Añez, Nicholas M. Anstey, Abraham Aseffa, Ashenafi Assefa, Ghulam R. Awab, J. Kevin Baird, Bridget E. Barber, Isabelle Borghini-Fuhrer, Umberto D’Alessandro…

    Citation: BMC Medicine 2019 17:151

    Content type: Research article

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  2. Persons with human immunodeficiency virus (HIV) have higher risks for myocardial infarction (MI) than the general population. This is driven in part by higher type 2 MI (T2MI, due to coronary supply-demand mis...

    Authors: Matthew J. Feinstein, Robin M. Nance, J. A. Chris Delaney, Susan R. Heckbert, Matthew J. Budoff, Daniel R. Drozd, Greer A. Burkholder, James H. Willig, Michael J. Mugavero, William C. Mathews, Richard D. Moore, Joseph J. Eron, Sonia Napravnik, Peter W. Hunt, Elvin Geng, Priscilla Hsue…

    Citation: BMC Medicine 2019 17:149

    Content type: Research article

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  3. Colorectal cancer is the third most common cancer in the world. In this study, we assessed the long-term survival characteristics and prognostic associations and potential time-varying effects of clinico-demog...

    Authors: Yajun Yu, Megan Carey, William Pollett, Jane Green, Elizabeth Dicks, Patrick Parfrey, Yildiz E. Yilmaz and Sevtap Savas

    Citation: BMC Medicine 2019 17:150

    Content type: Research article

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  4. Figure 3 in the original article [1] is incorrect; labels for secondary outcomes have been shifted and do not correspond to the numbers reported in the table (Additional file 8). The corrected version can be s...

    Authors: Isabelle Boutron, Romana Haneef, Amélie Yavchitz, Gabriel Baron, John Novack, Ivan Oransky, Gary Schwitzer and Philippe Ravaud

    Citation: BMC Medicine 2019 17:147

    Content type: Correction

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    The original article was published in BMC Medicine 2019 17:105

  5. A recent cohort study among Papua New Guinean women surprisingly showed iron deficiency during pregnancy to be associated with increased birth weight. These findings seemingly contradict previous trial evidenc...

    Authors: Hans Verhoef, Martin N. Mwangi, Carla Cerami and Andrew M. Prentice

    Citation: BMC Medicine 2019 17:146

    Content type: Correspondence

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    The Correspondence to this article has been published in BMC Medicine 2019 17:153

    The original article was published in BMC Medicine 2018 16:156

  6. The presence of additional chronic conditions has a significant impact on the treatment and management of type 2 diabetes (T2DM). Little is known about the patterns of comorbidities in this population. The aim...

    Authors: Magdalena Nowakowska, Salwa S. Zghebi, Darren M. Ashcroft, Iain Buchan, Carolyn Chew-Graham, Tim Holt, Christian Mallen, Harm Van Marwijk, Niels Peek, Rafael Perera-Salazar, David Reeves, Martin K. Rutter, Stephen F. Weng, Nadeem Qureshi, Mamas A. Mamas and Evangelos Kontopantelis

    Citation: BMC Medicine 2019 17:145

    Content type: Research article

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    The Correction to this article has been published in BMC Medicine 2020 18:22

  7. Delirium affects > 15% of hospitalised patients but is grossly underdetected, contributing to poor care. The 4 ‘A’s Test (4AT, www.​the4AT.​com) is a sho...

    Authors: Susan D. Shenkin, Christopher Fox, Mary Godfrey, Najma Siddiqi, Steve Goodacre, John Young, Atul Anand, Alasdair Gray, Janet Hanley, Allan MacRaild, Jill Steven, Polly L. Black, Zoë Tieges, Julia Boyd, Jacqueline Stephen, Christopher J. Weir…

    Citation: BMC Medicine 2019 17:138

    Content type: Research article

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  8. Celiac disease remains a challenging condition because of a steady increase in knowledge tackling its pathophysiology, diagnosis, management, and possible therapeutic options.

    Authors: Giacomo Caio, Umberto Volta, Anna Sapone, Daniel A. Leffler, Roberto De Giorgio, Carlo Catassi and Alessio Fasano

    Citation: BMC Medicine 2019 17:142

    Content type: Review

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  9. Since low insulin-like growth factor (IGF) 1 is often linked to inflammation, we analyze whether serum levels of IGF1 are associated with cardiovascular disease (CVD) in rheumatoid arthritis (RA) in a longitud...

    Authors: Malin C. Erlandsson, Lovisa Lyngfelt, N. David Åberg, Caroline Wasén, Rachelle A. Espino, Sofia Töyrä Silfverswärd, Mitra Nadali, Katharina Jood, Karin M.E. Andersson, Rille Pullerits and Maria I. Bokarewa

    Citation: BMC Medicine 2019 17:141

    Content type: Research article

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  10. Since the publication of this article [1] it has come to my attention that it contains an error in which the y-axis in Fig. 1 was inverted, thus incorrectly displaying a weak negative correlation rather than a...

    Authors: Jeremy C. Wyatt

    Citation: BMC Medicine 2019 17:144

    Content type: Correction

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    The original article was published in BMC Medicine 2018 16:225

  11. The objectives of this study were to understand the differences in mortality rate, risk factors for mortality, and cause of death distribution in three neonatal age sub-groups (0–2, 3–7, and 8–27 days) and ass...

    Authors: Rakhi Dandona, G. Anil Kumar, Debarshi Bhattacharya, Md. Akbar, Yamini Atmavilas, Priya Nanda and Lalit Dandona

    Citation: BMC Medicine 2019 17:140

    Content type: Research article

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  12. Clinical practice guidelines are an important source of information, designed to help clinicians integrate research evidence into their clinical practice. Digital education is increasingly used for clinical pr...

    Authors: Lorainne Tudor Car, Aijia Soong, Bhone Myint Kyaw, Kee Leng Chua, Naomi Low-Beer and Azeem Majeed

    Citation: BMC Medicine 2019 17:139

    Content type: Research article

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  13. Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver illness with a genetically heterogeneous background that can be accompanied by considerable morbidity and attendant health care costs. The pa...

    Authors: Bahram Namjou, Todd Lingren, Yongbo Huang, Sreeja Parameswaran, Beth L. Cobb, Ian B. Stanaway, John J. Connolly, Frank D. Mentch, Barbara Benoit, Xinnan Niu, Wei-Qi Wei, Robert J. Carroll, Jennifer A. Pacheco, Isaac T. W. Harley, Senad Divanovic, David S. Carrell…

    Citation: BMC Medicine 2019 17:135

    Content type: Research article

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  14. Risk prediction models are commonly used in practice to inform decisions on patients’ treatment. Uncertainty around risk scores beyond the confidence interval is rarely explored. We conducted an uncertainty an...

    Authors: Alexander Pate, Richard Emsley, Darren M. Ashcroft, Benjamin Brown and Tjeerd van Staa

    Citation: BMC Medicine 2019 17:134

    Content type: Research article

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    The Correction to this article has been published in BMC Medicine 2019 17:158

  15. There is great interest in and excitement about the concept of personalized or precision medicine and, in particular, advancing this vision via various ‘big data’ efforts. While these methods are necessary, th...

    Authors: Eric B. Hekler, Predrag Klasnja, Guillaume Chevance, Natalie M. Golaszewski, Dana Lewis and Ida Sim

    Citation: BMC Medicine 2019 17:133

    Content type: Debate

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  16. Smartphone apps are becoming increasingly popular for supporting diabetes self-management. A key aspect of diabetes self-management is appropriate medication-taking. This study aims to systematically assess an...

    Authors: Zhilian Huang, Elaine Lum, Geronimo Jimenez, Monika Semwal, Peter Sloot and Josip Car

    Citation: BMC Medicine 2019 17:127

    Content type: Research article

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  17. Hospitalisation is often harmful for people with dementia and results in high societal costs, so avoidance of unnecessary admissions is a global priority. However, no intervention has yet reduced admissions of...

    Authors: Hilary Shepherd, Gill Livingston, Justin Chan and Andrew Sommerlad

    Citation: BMC Medicine 2019 17:130

    Content type: Research article

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  18. Studies have suggested sex differences in the mortality rate associated with diabetes. We conducted a meta-analysis to estimate the relative effect of diabetes on the risk of all-cause, cancer, cardiovascular ...

    Authors: Yafeng Wang, Adrienne O’Neil, Yurui Jiao, Lijun Wang, Jingxin Huang, Yutao Lan, Yikun Zhu and Chuanhua Yu

    Citation: BMC Medicine 2019 17:136

    Content type: Research article

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  19. Monogenic diabetes (MgD) accounts for 1–2% of all diabetes cases. In adults, MgD is difficult to distinguish from common diabetes causes. We assessed the diagnosis rate and genetic spectrum of MgD using next-g...

    Authors: Xavier Donath, Cécile Saint-Martin, Danièle Dubois-Laforgue, Ramanan Rajasingham, François Mifsud, Cécile Ciangura, José Timsit and Christine Bellanné-Chantelot

    Citation: BMC Medicine 2019 17:132

    Content type: Research article

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  20. Autoimmune diseases are often preceded by an asymptomatic autoantibody-positive phase. In type 1 diabetes, the detection of autoantibodies to pancreatic islet antigens in genetically at-risk children is progno...

    Authors: Verena Sophia Hoffmann, Andreas Weiß, Christiane Winkler, Annette Knopff, Manja Jolink, Ezio Bonifacio and Anette-G. Ziegler

    Citation: BMC Medicine 2019 17:125

    Content type: Research article

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  21. Many parts of Africa have witnessed reductions in Plasmodium falciparum transmission over the last 15 years. Since immunity to malaria is acquired more rapidly at higher transmission, the slower acquisition of im...

    Authors: Patricia Njuguna, Kathryn Maitland, Amek Nyaguara, Daniel Mwanga, Polycarp Mogeni, Neema Mturi, Shebe Mohammed, Gabriel Mwambingu, Caroline Ngetsa, Kenedy Awuondo, Brett Lowe, Ifedayo Adetifa, J. Anthony G. Scott, Thomas N. Williams, Sarah Atkinson, Faith Osier…

    Citation: BMC Medicine 2019 17:124

    Content type: Research article

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  22. Every year, 90,000 people may die from melioidosis. Vaccine candidates have not proceeded past animal studies, partly due to uncertainty around the potential market size. This study aims to estimate the potent...

    Authors: Nantasit Luangasanatip, Stefan Flasche, David A. B. Dance, Direk Limmathurotsakul, Bart J. Currie, Chiranjay Mukhopadhyay, Tim Atkins, Richard Titball and Mark Jit

    Citation: BMC Medicine 2019 17:129

    Content type: Research article

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  23. Tobacco smoking is a leading cause of cardiovascular disease (CVD) morbidity and mortality. Evidence on the relation of smoking to different subtypes of CVD, across fatal and non-fatal outcomes, is limited.

    Authors: Emily Banks, Grace Joshy, Rosemary J. Korda, Bill Stavreski, Kay Soga, Sam Egger, Cathy Day, Naomi E. Clarke, Sarah Lewington and Alan D. Lopez

    Citation: BMC Medicine 2019 17:128

    Content type: Research article

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  24. Recovery following a stroke is a long and ongoing process. Post-stroke follow-up after leaving the hospital is recommended. Methods for follow-up patients include face-to-face, via the telephone, post or onlin...

    Authors: Jonathan Hewitt, Anna Pennington, Alexander Smith, Stephanie Gething, Michelle Price, James White, Richard Dewar and Ben Carter

    Citation: BMC Medicine 2019 17:111

    Content type: Research article

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  25. World Health Organization rehydration management guidelines (plan C) for severe dehydration are widely practiced in resource-poor settings, but never formally evaluated in a trial. The Fluid Expansion as a Sup...

    Authors: Kirsty A. Houston, Jack Gibb, Peter Olupot-Olupot, Nchafatso Obonyo, Ayub Mpoya, Margaret Nakuya, Rita Muhindo, Sophie Uyoga, Jennifer A. Evans, Roisin Connon, Diana M. Gibb, Elizabeth C. George and Kathryn Maitland

    Citation: BMC Medicine 2019 17:122

    Content type: Research article

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  26. Type 2 diabetes mellitus (T2DM) is a major cause of morbidity and mortality worldwide. Early interventions may help to delay or prevent onset of cardiometabolic endpoints of clinical importance to T2DM patients.

    Authors: Efstathia Gkioni, Ketevan Glonti, Susanna Dodd and Carrol Gamble

    Citation: BMC Medicine 2019 17:121

    Content type: Correspondence

    Published on:

    The Correspondence to this article has been published in BMC Medicine 2019 17:162

    The original article was published in BMC Medicine 2017 15:146

  27. Verbal autopsies with physician assignment of cause of death (COD) are commonly used in settings where medical certification of deaths is uncommon. It remains unanswered if automated algorithms can replace phy...

    Authors: Prabhat Jha, Dinesh Kumar, Rajesh Dikshit, Atul Budukh, Rehana Begum, Prabha Sati, Patrycja Kolpak, Richard Wen, Shyamsundar J. Raithatha, Utkarsh Shah, Zehang Richard Li, Lukasz Aleksandrowicz, Prakash Shah, Kapila Piyasena, Tyler H. McCormick, Hellen Gelband…

    Citation: BMC Medicine 2019 17:116

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2019 17:131

  28. Abnormal BMI is associated with discouraging IVF outcomes in fresh autologous or oocyte donor cycles, whether or not such a relation also holds true for women undergoing frozen-thawed embryo transfer (FET) rem...

    Authors: Jie Zhang, Hongfang Liu, Xiaoyan Mao, Qiuju Chen, Yong Fan, Yitao Xiao, Yun Wang and Yanping Kuang

    Citation: BMC Medicine 2019 17:114

    Content type: Research article

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  29. HIV epidemiology among female sex workers (FSWs) and their clients in the Middle East and North Africa (MENA) region is poorly understood. We addressed this gap through a comprehensive epidemiological assessment.

    Authors: Hiam Chemaitelly, Helen A. Weiss, Clara Calvert, Manale Harfouche and Laith J. Abu-Raddad

    Citation: BMC Medicine 2019 17:119

    Content type: Research article

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  30. For many infectious conditions, the optimal antibiotic course length remains unclear. The estimation of course length must consider the important trade-off between maximising short- and long-term efficacy and ...

    Authors: Koen B. Pouwels, Mo Yin, Christopher C. Butler, Ben S. Cooper, Sarah Wordsworth, A. Sarah Walker and Julie V. Robotham

    Citation: BMC Medicine 2019 17:115

    Content type: Opinion

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  31. Although peer reviewers play a key role in the manuscript review process, their roles and tasks are poorly defined. Clarity around this issue is important as it may influence the quality of peer reviewer repor...

    Authors: Ketevan Glonti, Daniel Cauchi, Erik Cobo, Isabelle Boutron, David Moher and Darko Hren

    Citation: BMC Medicine 2019 17:118

    Content type: Research article

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  32. Personalized medicine is the tailoring of treatment to the individual characteristics of patients. Once a treatment has been tested in a clinical trial and its effect overall quantified, it would be of great v...

    Authors: Francesca Bovis, Luca Carmisciano, Alessio Signori, Matteo Pardini, Joshua R. Steinerman, Thomas Li, Aaron P. Tansy and Maria Pia Sormani

    Citation: BMC Medicine 2019 17:113

    Content type: Research article

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  33. Postmarketing commitments are clinical studies that pharmaceutical companies agree to conduct at the time of FDA approval, but which are not required by statute or regulation. As FDA increasingly adopts a life...

    Authors: Joshua D. Wallach, Anita T. Luxkaranayagam, Sanket S. Dhruva, Jennifer E. Miller and Joseph S. Ross

    Citation: BMC Medicine 2019 17:117

    Content type: Research article

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  34. Pharmacogenetics (PGx) is currently implemented in hospitals to optimize therapy with high-risk drugs. However, many drugs with dosing recommendations from the Dutch Pharmacogenetics Working Group and the Clin...

    Authors: P. C. D. Bank, J. J. Swen and H. J. Guchelaar

    Citation: BMC Medicine 2019 17:110

    Content type: Research article

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  35. The Framingham risk models and pooled cohort equations (PCE) are widely used and advocated in guidelines for predicting 10-year risk of developing coronary heart disease (CHD) and cardiovascular disease (CVD) ...

    Authors: Johanna A. Damen, Romin Pajouheshnia, Pauline Heus, Karel G. M. Moons, Johannes B. Reitsma, Rob J. P. M. Scholten, Lotty Hooft and Thomas P. A. Debray

    Citation: BMC Medicine 2019 17:109

    Content type: Research article

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  36. Multimorbidity is an emerging public health priority. Physical activity (PA) is recommended as one of the main lifestyle behaviours, yet the benefits of PA for people with multimorbidity are unclear. We assess...

    Authors: Yogini V. Chudasama, Kamlesh K. Khunti, Francesco Zaccardi, Alex V. Rowlands, Thomas Yates, Clare L. Gillies, Melanie J. Davies and Nafeesa N. Dhalwani

    Citation: BMC Medicine 2019 17:108

    Content type: Research article

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  37. Infectious disease epidemics are a constant threat, and while we can strengthen preparedness in advance, inevitably, we will sometimes be caught unaware by novel outbreaks. To address the challenge of rapidly ...

    Authors: Louise Sigfrid, Catrin Moore, Alex P. Salam, Nicola Maayan, Candyce Hamel, Chantelle Garritty, Vittoria Lutje, Brian Buckley, Karla Soares-Weiser, Rachel Marshall, Mike Clarke and Peter Horby

    Citation: BMC Medicine 2019 17:107

    Content type: Research article

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  38. Intratumoral immune infiltrates have manifested a robust prognostic signature in patients with hepatocellular carcinoma (HCC). We hypothesized that a novel tissue-related immune signature (TRIS) could improve ...

    Authors: Meng-Xin Tian, Wei-Ren Liu, Han Wang, Yu-Fu Zhou, Lei Jin, Xi-Fei Jiang, Chen-Yang Tao, Zheng Tang, Pei-Yun Zhou, Yuan Fang, Wei-Feng Qu, Zhen-Bin Ding, Yuan-Fei Peng, Zhi Dai, Shuang-Jian Qiu, Jian Zhou…

    Citation: BMC Medicine 2019 17:106

    Content type: Research article

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  39. News stories represent an important source of information. We aimed to evaluate the impact of “spin” (i.e., misrepresentation of study results) in health news stories reporting studies of pharmacologic treatme...

    Authors: Isabelle Boutron, Romana Haneef, Amélie Yavchitz, Gabriel Baron, John Novack, Ivan Oransky, Gary Schwitzer and Philippe Ravaud

    Citation: BMC Medicine 2019 17:105

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Medicine 2019 17:147

  40. Reducing maternal mortality is a key focus of development strategies and one of the indicators used to measure progress towards achieving the Sustainable Development Goals. In the absence of medical certificat...

    Authors: Ian D. Riley, Riley H. Hazard, Rohina Joshi, Hafizur Rahman Chowdhury and Alan D. Lopez

    Citation: BMC Medicine 2019 17:104

    Content type: Correspondence

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  41. Accurate and timely diagnosis of malaria is essential for disease management and surveillance. Thin and thick blood smear microscopy and malaria rapid diagnostic tests (RDTs) are standard malaria diagnostics, ...

    Authors: Annelies Post, Berenger Kaboré, Isaie J. Reuling, Joel Bognini, Wouter van der Heijden, Salou Diallo, Palpouguini Lompo, Basile Kam, Natacha Herssens, Kjerstin Lanke, Teun Bousema, Robert W. Sauerwein, Halidou Tinto, Jan Jacobs, Quirijn de Mast and Andre J. van der Ven

    Citation: BMC Medicine 2019 17:103

    Content type: Research article

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  42. Verbal autopsy is an increasingly important methodology for assigning causes to otherwise uncertified deaths, which amount to around 50% of global mortality and cause much uncertainty for health planning. The ...

    Authors: Peter Byass, Laith Hussain-Alkhateeb, Lucia D’Ambruoso, Samuel Clark, Justine Davies, Edward Fottrell, Jon Bird, Chodziwadziwa Kabudula, Stephen Tollman, Kathleen Kahn, Linus Schiöler and Max Petzold

    Citation: BMC Medicine 2019 17:102

    Content type: Software

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