Skip to main content

Articles

Page 3 of 66

  1. Differences in definitions and methodological approaches have hindered comparison and synthesis of economic evaluation results across multiple health domains, including immunization. At the request of the Worl...

    Authors: Ann Levin, Laura Boonstoppel, Logan Brenzel, Ulla Griffiths, Raymond Hutubessy, Mark Jit, Vittal Mogasale, Sarah Pallas, Stephen Resch, Christian Suharlim and Karene Hoi Ting Yeung
    Citation: BMC Medicine 2022 20:88
  2. Antagonizing the androgen-receptor (AR) pathway is an effective treatment strategy for patients with metastatic castration-resistant prostate cancer (CRPC). Here, we report the results of a first-in-human phas...

    Authors: Xiaojian Qin, Dongmei Ji, Weijie Gu, Weiqing Han, Hong Luo, Chuanjun Du, Qing Zou, Zhongquan Sun, Chaohong He, Shaoxing Zhu, Tie Chong, Xin Yao, Ben Wan, Xinfeng Yang, Aobing Bai, Chunlei Jin…
    Citation: BMC Medicine 2022 20:84
  3. The COVID-19 pandemic is caused by the betacoronavirus SARS-CoV-2. In November 2021, the Omicron variant was discovered and immediately classified as a variant of concern (VOC), since it shows substantially mo...

    Authors: Maren Schubert, Federico Bertoglio, Stephan Steinke, Philip Alexander Heine, Mario Alberto Ynga-Durand, Henrike Maass, Josè Camilla Sammartino, Irene Cassaniti, Fanglei Zuo, Likun Du, Janin Korn, Marko Milošević, Esther Veronika Wenzel, Fran Krstanović, Saskia Polten, Marina Pribanić-Matešić…
    Citation: BMC Medicine 2022 20:102
  4. The shortage of available organs for life-saving transplants persists worldwide. While a majority support donating their organs or tissue when they die, many have not registered their wish to do so. When regis...

    Authors: Alvin Ho-ting Li, Amit X. Garg, Jeremy M. Grimshaw, Versha Prakash, Alexie J. Dunnett, Stephanie N. Dixon, Monica Taljaard, Joanna Mitchell, Kyla L. Naylor, Cathy Faulds, Rachel Bevan, Leah Getchell, Greg Knoll, S. Joseph Kim, Jessica Sontrop, Allison Tong…
    Citation: BMC Medicine 2022 20:75
  5. Studies have suggested incremental short-term adverse events (AE) after repeated vaccination. In this report, we assessed occurrence and risk factors for short-term AEs following repeated SARS-CoV-2 vaccinatio...

    Authors: Luuk Wieske, Laura Y. L. Kummer, Koos P. J. van Dam, Eileen W. Stalman, Anneke J. van der Kooi, Joost Raaphorst, Mark Löwenberg, R. Bart Takkenberg, Adriaan G. Volkers, Geert R. A. M. D’Haens, Sander W. Tas, Phyllis I. Spuls, Marcel W. Bekkenk, Annelie H. Musters, Nicoline F. Post, Angela L. Bosma…
    Citation: BMC Medicine 2022 20:100
  6. Accurate and non-invasive diagnosis of pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP) can avoid unnecessary puncture and surgery. This study aimed to develop a deep learning radiomics (D...

    Authors: Tong Tong, Jionghui Gu, Dong Xu, Ling Song, Qiyu Zhao, Fang Cheng, Zhiqiang Yuan, Shuyuan Tian, Xin Yang, Jie Tian, Kun Wang and Tian’an Jiang
    Citation: BMC Medicine 2022 20:74
  7. Authors: Chathika K. Weerasuriya, Rebecca C. Harris, C. Finn McQuaid, Fiammetta Bozzani, Yunzhou Ruan, Renzhong Li, Tao Li, Kirankumar Rade, Raghuram Rao, Ann M. Ginsberg, Gabriela B. Gomez and Richard G. White
    Citation: BMC Medicine 2022 20:99

    The original article was published in BMC Medicine 2021 19:60

  8. Type 2 diabetes is one of the leading causes of chronic kidney failure, which increases globally and represents a significant threat to public health. People from the Middle East represent one of the largest i...

    Authors: Siham A. Mohamed, Juan Fernadez-Tajes, Paul W. Franks and Louise Bennet
    Citation: BMC Medicine 2022 20:76
  9. The combined health impact of physical activity (PA) and air pollution on chronic obstructive pulmonary disease (COPD) remains unclear. We investigated the joint effects of habitual PA and long-term fine parti...

    Authors: Lan Chen, Miao Cai, Haitao Li, Xiaojie Wang, Fei Tian, Yinglin Wu, Zilong Zhang and Hualiang Lin
    Citation: BMC Medicine 2022 20:70
  10. The success of antithrombotic therapies is assessed based on thrombotic and bleeding events. Simultaneously assessing both kinds of events might be challenging, and recurrent bleeding events are often ignored....

    Authors: Kunihiko Matsui, Satoshi Yasuda, Koichi Kaikita, Masaharu Akao, Junya Ako, Tetsuya Matoba, Masato Nakamura, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama and Hisao Ogawa
    Citation: BMC Medicine 2022 20:69
  11. Rapid antigen diagnostic tests (Ag-RDTs) are the most widely used point-of-care tests for detecting SARS-CoV-2 infection. Since the accuracy may have altered by changes in SARS-CoV-2 epidemiology, indications ...

    Authors: Roderick P. Venekamp, Irene K. Veldhuijzen, Karel G. M. Moons, Wouter van den Bijllaardt, Suzan D. Pas, Esther B. Lodder, Richard Molenkamp, Zsofi Igloi, Constantijn Wijers, Claudy Oliveira dos Santos, Sylvia B. Debast, Marjan J. Bruins, Khaled Polad, Carla R. S. Nagel-Imming, Wanda G. H. Han, Janneke H. H. M. van de Wijgert…
    Citation: BMC Medicine 2022 20:97
  12. The associations of cancer with types of diets, including vegetarian, fish, and poultry-containing diets, remain unclear. The aim of this study was, therefore, to investigate the association of type of diet wi...

    Authors: Solange Parra-Soto, Danay Ahumada, Fanny Petermann-Rocha, Jirapitcha Boonpoor, Jose Lara Gallegos, Jana Anderson, Linda Sharp, Fiona C. Malcomson, Katherine M. Livingstone, John C. Mathers, Jill P. Pell, Frederick K. Ho and Carlos Celis-Morales
    Citation: BMC Medicine 2022 20:79

    The Commentary to this article has been published in BMC Medicine 2022 20:81

    The Research article to this article has been published in BMC Medicine 2022 20:73

  13. Following a vegetarian diet has become increasingly popular and some evidence suggests that being vegetarian may be associated with a lower risk of cancer overall. However, for specific cancer sites, the evide...

    Authors: Cody Z. Watling, Julie A. Schmidt, Yashvee Dunneram, Tammy Y. N. Tong, Rebecca K. Kelly, Anika Knuppel, Ruth C. Travis, Timothy J. Key and Aurora Perez-Cornago
    Citation: BMC Medicine 2022 20:73

    The Commentary to this article has been published in BMC Medicine 2022 20:81

    The Research article to this article has been published in BMC Medicine 2022 20:79

  14. The active surveillance of students is proposed as an effective strategy to contain SARS-CoV-2 spread and prevent schools’ closure. Saliva for molecular testing is as sensitive as naso-pharyngeal swab (NPS), s...

    Authors: Daniela Basso, Ada Aita, Filippo Navaglia, Paola Mason, Stefania Moz, Alessio Pinato, Barbara Melloni, Luca Iannelli, Andrea Padoan, Chiara Cosma, Angelo Moretto, Alberto Scuttari, Daniela Mapelli, Rosario Rizzuto and Mario Plebani
    Citation: BMC Medicine 2022 20:96
  15. Long-term-specific sequelae or persistent symptoms (SPS) after hospitalisation due to COVID-19 are not known. The aim of this study was to explore the presence of SPS 12 months after discharge in survivors hos...

    Authors: Mario Rivera-Izquierdo, Antonio Jesús Láinez-Ramos-Bossini, Inmaculada Guerrero-Fernández de Alba, Rocío Ortiz-González-Serna, Álvaro Serrano-Ortiz, Nicolás Francisco Fernández-Martínez, Rafael Ruiz-Montero and Jorge A. Cervilla
    Citation: BMC Medicine 2022 20:92
  16. Attention deficit hyperactivity disorder (ADHD) is a highly heritable, neurodevelopmental disorder known to associate with more than double the risk of death compared with people without ADHD. Because most res...

    Authors: Olesya Ajnakina, Diana Shamsutdinova, Theresa Wimberley, Søren Dalsgaard and Andrew Steptoe
    Citation: BMC Medicine 2022 20:62
  17. Prospective population-based studies investigating multiple determinants of pre-vaccination antibody responses to SARS-CoV-2 are lacking.

    Authors: Mohammad Talaei, Sian Faustini, Hayley Holt, David A. Jolliffe, Giulia Vivaldi, Matthew Greenig, Natalia Perdek, Sheena Maltby, Carola M. Bigogno, Jane Symons, Gwyneth A. Davies, Ronan A. Lyons, Christopher J. Griffiths, Frank Kee, Aziz Sheikh, Alex G. Richter…
    Citation: BMC Medicine 2022 20:87
  18. Excisional treatment of cervical intraepithelial neoplasia (CIN) has been associated with increased risk of preterm delivery (PTD), although the underlying mechanism is as yet unclear. Studies on formalin-fixe...

    Authors: Johanna Wiik, Cecilia Kärrberg, Staffan Nilsson, Björn Strander, Bo Jacobsson and Verena Sengpiel
    Citation: BMC Medicine 2022 20:61
  19. HRV has mostly shown associations with systolic dysfunction and more recently, with diastolic dysfunction in Heart failure (HF) patients. But the role of sympathetic nervous system in changes of left ventricul...

    Authors: Banafsheh Arshi, Sven Geurts, Martijn J. Tilly, Marten van den Berg, Jan A. Kors, Dimitris Rizopoulos, M. Arfan Ikram and Maryam Kavousi
    Citation: BMC Medicine 2022 20:91
  20. Forecasting healthcare demand is essential in epidemic settings, both to inform situational awareness and facilitate resource planning. Ideally, forecasts should be robust across time and locations. During the...

    Authors: Sophie Meakin, Sam Abbott, Nikos Bosse, James Munday, Hugo Gruson, Joel Hellewell, Katharine Sherratt and Sebastian Funk
    Citation: BMC Medicine 2022 20:86
  21. Childhood abuse and neglect have been associated with premenstrual disorders (PMDs), including premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD). However, the associations of other adverse...

    Authors: Qian Yang, Edda Björk Þórðardóttir, Arna Hauksdóttir, Thor Aspelund, Jóhanna Jakobsdóttir, Thorhildur Halldorsdottir, Gunnar Tomasson, Harpa Rúnarsdóttir, Hilda Björk Danielsdottir, Elizabeth R. Bertone-Johnson, Arvid Sjölander, Fang Fang, Donghao Lu and Unnur Anna Valdimarsdóttir
    Citation: BMC Medicine 2022 20:60
  22. Vitamin D status has been implicated in COVID-19 disease. The objective of the COVID-VIT-D trial was to investigate if an oral bolus of cholecalciferol (100,000 IU) administered at hospital admission influence...

    Authors: Jorge B. Cannata-Andía, Augusto Díaz-Sottolano, Pehuén Fernández, Carmen Palomo-Antequera, Pablo Herrero-Puente, Ricardo Mouzo, Natalia Carrillo-López, Sara Panizo, Guillermo H. Ibañez, Carlos A. Cusumano, Carolina Ballarino, Vicente Sánchez-Polo, Jacqueline Pefaur-Penna, Irene Maderuelo-Riesco, Jesús Calviño-Varela, Mónica D. Gómez…
    Citation: BMC Medicine 2022 20:83
  23. In countries with high COVID-19 vaccination rates the SARS-CoV-2 Delta variant resulted in rapidly increasing case numbers. This study evaluated the use of non-pharmaceutical interventions (NPIs) coupled with ...

    Authors: George J. Milne, Julian Carrivick and David Whyatt
    Citation: BMC Medicine 2022 20:80
  24. Patients with disorders of gut-brain interaction (DGBI) report meal intake to be associated with symptoms. DGBI patients with meal-related symptoms may have more severe symptoms overall and worse health outcom...

    Authors: Esther Colomier, Chloé Melchior, Joost P. Algera, Jóhann P. Hreinsson, Stine Störsrud, Hans Törnblom, Lukas Van Oudenhove, Olafur S. Palsson, Shrikant I. Bangdiwala, Ami D. Sperber, Jan Tack and Magnus Simrén
    Citation: BMC Medicine 2022 20:71
  25. Genome-wide association studies (GWASs) have identified multiple risk loci for Parkinson’s disease (PD). However, identifying the functional (or potential causal) variants in the reported risk loci and elucida...

    Authors: Rui Chen, Jiewei Liu, Shiwu Li, Xiaoyan Li, Yongxia Huo, Yong-Gang Yao, Xiao Xiao, Ming Li and Xiong-Jian Luo
    Citation: BMC Medicine 2022 20:68
  26. Contested evidence suggests that obesity confers no risk to health in people who have a healthy lifestyle, particularly if there are no metabolic complications of obesity. The aim was to examine the associatio...

    Authors: Laura Heath, Susan A. Jebb, Paul Aveyard and Carmen Piernas
    Citation: BMC Medicine 2022 20:65
  27. Breast cancer is the most commonly diagnosed cancer worldwide and is one of the leading causes of cancer death. The incidence, pathological features, and clinical outcomes in breast cancer differ by geographic...

    Authors: Kelly A. Hirko, Gabrielle Rocque, Erica Reasor, Ammanuel Taye, Alex Daly, Ramsey I. Cutress, Ellen R. Copson, Dae-Won Lee, Kyung-Hun Lee, Seock-Ah Im and Yeon Hee Park
    Citation: BMC Medicine 2022 20:72
  28. The comorbidity between polycystic ovary syndrome (PCOS) and obesity has long been observed in clinical settings, but their shared genetic basis remains unclear.

    Authors: Qianwen Liu, Zhaozhong Zhu, Peter Kraft, Qiaolin Deng, Elisabet Stener-Victorin and Xia Jiang
    Citation: BMC Medicine 2022 20:66
  29. Bevacizumab improves survival outcomes in women diagnosed with epithelial ovarian cancer (EOC). Pre-clinical data showed that the c-MET/VEGFR-2 heterocomplex negates VEGF inhibition through activation of c-MET...

    Authors: Robert D. Morgan, Cristina Ferreras, Isabel Peset, Egle Avizienyte, Andrew G. Renehan, Richard J. Edmondson, Alexander D. Murphy, Shibani Nicum, Thomas Van Brussel, Andrew R. Clamp, Diether Lambrechts, Cong Zhou and Gordon C. Jayson
    Citation: BMC Medicine 2022 20:59
  30. China experiences large variations in influenza seasonal activity. We aim to update and improve the current understanding of regional-based within-year variations of influenza activity across mainland China to...

    Authors: Charlie Diamond, Hui Gong, Fiona Yueqian Sun, Yang Liu, Billy J. Quilty, Mark Jit, Juan Yang, Hongjie Yu, W. John Edmunds and Marc Baguelin
    Citation: BMC Medicine 2022 20:58
  31. The World Health Organization’s (WHO) 25X25 goal aims for a 25% relative reduction in premature death due to four non-communicable diseases (NCD4)—cancer, cardiovascular disease, chronic respiratory diseases a...

    Authors: Alison Wijnen, Karen Bishop, Grace Joshy, Yuehan Zhang, Emily Banks and Ellie Paige
    Citation: BMC Medicine 2022 20:57
  32. Emerging findings highlighted the associations of mental illness to nutrition and dysbiosis in the intestinal microbiota, but the underlying mechanisms, especially in schizophrenia (SZ), remain unclarified.

    Authors: Ying Liang, Xing Shi, Yang Shen, Zhuoran Huang, Jian Wang, Changjun Shao, Yanan Chu, Jing Chen, Jun Yu and Yu Kang
    Citation: BMC Medicine 2022 20:67
  33. Dietary modifications are crucial for managing newly diagnosed type 2 diabetes mellitus (T2DM) and preventing its health complications, but many patients fail to achieve clinical goals with diet alone. We soug...

    Authors: Michal Rein, Orly Ben-Yacov, Anastasia Godneva, Smadar Shilo, Niv Zmora, Dmitry Kolobkov, Noa Cohen-Dolev, Bat-Chen Wolf, Noa Kosower, Maya Lotan-Pompan, Adina Weinberger, Zamir Halpern, Shira Zelber-Sagi, Eran Elinav and Eran Segal
    Citation: BMC Medicine 2022 20:56
  34. Metastatic cervical squamous cell carcinoma (CSCC) has poor prognosis and is recalcitrant to the current treatment strategies, which warrants the necessity to identify novel prognostic markers and therapeutic ...

    Authors: Yuanyuan Zhang, Ning Li, Guangwen Yuan, Hongwen Yao, Die Zhang, Nan Li, Gongyi Zhang, Yangchun Sun, Wenpeng Wang, Jia Zeng, Ningzhi Xu, Mei Liu and Lingying Wu
    Citation: BMC Medicine 2022 20:55
  35. selfBACK, an artificial intelligence (AI)-based app delivering evidence-based tailored self-management support to people with low back pain (LBP), has been shown to reduce LBP-related disability when added to usu...

    Authors: Cecilie K. Øverås, Tom I. L. Nilsen, Barbara I. Nicholl, Guy Rughani, Karen Wood, Karen Søgaard, Frances S. Mair and Jan Hartvigsen
    Citation: BMC Medicine 2022 20:53
  36. The evolution of SARS-CoV-2 has led to the emergence of several new variants, and few data are available on the impact of vaccination on SARS-CoV-2 variants. We aimed to assess the association between natural ...

    Authors: Giovanni Corrao, Matteo Franchi, Federico Rea, Danilo Cereda, Antonio Barone, Catia Rosanna Borriello, Petra Giulia Della Valle, Michele Ercolanoni, Ida Fortino, Jose Jara, Olivia Leoni, Francesco Mazziotta, Elisabetta Pierini, Giuseppe Preziosi, Marcello Tirani, Massimo Galli…
    Citation: BMC Medicine 2022 20:52
  37. DNA methylation-associated studies on biliary tract cancer (BTC), including cholangiocarcinoma (CCA) and gallbladder cancer (GBC), may improve the BTC classification scheme. We proposed to identify the shared ...

    Authors: Zhiquan Qiu, Jun Ji, Yu Xu, Yan Zhu, Chunfang Gao, Guoqiang Wang, Chengcheng Li, Yuzi Zhang, Jing Zhao, Chenyang Wang, Xiaofang Wen, Zhou Zhang, Bingsi Li, Zhihong Zhang, Shangli Cai, Bin Li…
    Citation: BMC Medicine 2022 20:64
  38. Cardiovascular and renal diseases (CVRD) are major causes of mortality in individuals with type 2 diabetes (T2D). Studies of lifetime risk have neither considered all CVRD together nor the relative contributio...

    Authors: Ruiqi Zhang, Jil Billy Mamza, Tamsin Morris, George Godfrey, Folkert W. Asselbergs, Spiros Denaxas, Harry Hemingway and Amitava Banerjee
    Citation: BMC Medicine 2022 20:63

    The Correction to this article has been published in BMC Medicine 2022 20:121

  39. Prostate-specific antigen (PSA) is a commonly used test to detect prostate cancer. Attention has mostly focused on the use of PSA in screening asymptomatic patients, but the diagnostic accuracy of PSA for pros...

    Authors: Samuel W. D. Merriel, Lucy Pocock, Emma Gilbert, Sam Creavin, Fiona M. Walter, Anne Spencer and Willie Hamilton
    Citation: BMC Medicine 2022 20:54
  40. The Kingdom of Saudi Arabia (KSA) quickly controlled the spread of SARS-CoV-2 by implementing several non-pharmaceutical interventions (NPIs), including suspension of international and national travel, local c...

    Authors: Donal Bisanzio, Richard Reithinger, Ada Alqunaibet, Sami Almudarra, Reem F. Alsukait, Di Dong, Yi Zhang, Sameh El-Saharty and Christopher H. Herbst
    Citation: BMC Medicine 2022 20:51
  41. A substantial portion of people with COVID-19 subsequently experience lasting symptoms including fatigue, shortness of breath, and neurological complaints such as cognitive dysfunction many months after acute ...

    Authors: Daniel Munblit, Timothy R. Nicholson, Dale M. Needham, Nina Seylanova, Callum Parr, Jessica Chen, Alisa Kokorina, Louise Sigfrid, Danilo Buonsenso, Shinjini Bhatnagar, Ramachandran Thiruvengadam, Ann M. Parker, Jacobus Preller, Sergey Avdeev, Frederikus A. Klok, Allison Tong…
    Citation: BMC Medicine 2022 20:50
  42. Fractures are a major health problem in aging societies. Preventive approaches combining bone health and fall prevention are rare. The osteoporotic fracture prevention program in rural areas (OFRA) is a health...

    Authors: Kilian Rapp, Sarah E. Lamb, Patrick Roigk, Clemens Becker, Claudia Konnopka, Hans-Helmut König, Raphael S. Peter, Dietrich Rothenbacher and Gisela Büchele
    Citation: BMC Medicine 2022 20:49
  43. Limitations to accessing delivery care services increase the risks of adverse outcomes during pregnancy and delivery for all pregnant women, particularly among adolescents in LMICs. In order to inform adolesce...

    Authors: Md. Mizanur Rahman, Hiroko Taniguchi, Raïssa Shiyghan Nsashiyi, Rashedul Islam, Syed Riaz Mahmud, Shafiur Rahman, Jenny Jung and Shahjahan Khan
    Citation: BMC Medicine 2022 20:46
  44. Previous observational studies suggested that a reduction in estimated glomerular filtration rate (eGFR) or a supranormal eGFR value was associated with adverse cardiovascular risks. However, a previous Mendel...

    Authors: Sehoon Park, Soojin Lee, Yaerim Kim, Semin Cho, Hyeok Huh, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim and Dong Ki Kim
    Citation: BMC Medicine 2022 20:44
  45. Evidence associating diet with the incidence of renal cell carcinoma (RCC) is inconclusive. We aimed to summarize evidence associating dietary factors with RCC incidence and assess the strength and validity of...

    Authors: Zhanchen Liao, Zhitao Fang, Siqi Gou, Yong Luo, Yiqi Liu, Zhun He, Xin Li, Yansong Peng, Zheng Fu, Dongjin Li, Haiyun Chen and Zhigang Luo
    Citation: BMC Medicine 2022 20:39
  46. Studies have reported an increased risk of mortality among people prescribed mirtazapine compared to other antidepressants. The study aimed to compare all-cause and cause-specific mortality between adults pres...

    Authors: Rebecca M. Joseph, Ruth H. Jack, Richard Morriss, Roger David Knaggs, Debbie Butler, Chris Hollis, Julia Hippisley-Cox and Carol Coupland
    Citation: BMC Medicine 2022 20:43
  47. We aimed to map and describe the current state of Mendelian randomization (MR) literature on cancer risk and to identify associations supported by robust evidence.

    Authors: Georgios Markozannes, Afroditi Kanellopoulou, Olympia Dimopoulou, Dimitrios Kosmidis, Xiaomeng Zhang, Lijuan Wang, Evropi Theodoratou, Dipender Gill, Stephen Burgess and Konstantinos K. Tsilidis
    Citation: BMC Medicine 2022 20:41
  48. Donepezil, galantamine, rivastigmine and memantine are potentially effective interventions for cognitive impairment in dementia, but the use of these drugs has not been personalised to individual patients yet....

    Authors: Qiang Liu, Nemanja Vaci, Ivan Koychev, Andrey Kormilitzin, Zhenpeng Li, Andrea Cipriani and Alejo Nevado-Holgado
    Citation: BMC Medicine 2022 20:45