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  1. Indobufen is widely used in patients with aspirin intolerance in East Asia. The OPTION trial launched by our cardiac center examined the performance of indobufen based dual antiplatelet therapy (DAPT) after pe...

    Authors: Chunfeng Dai, Muyin Liu, Zheng Yang, Youran Li, You Zhou, Danbo Lu, Yan Xia, Ao Chen, Chenguang Li, Hao Lu, Yuxiang Dai, Jianying Ma, Zhangwei Chen, Juying Qian and Junbo Ge
    Citation: BMC Medicine 2024 22:148
  2. Thyroid nodule (TN) patients in China are subject to overdiagnosis and overtreatment. The implementation of existing technologies such as thyroid ultrasonography has indeed contributed to the improved diagnost...

    Authors: Feihang Wang, Danyang Zhao, Wang-yang Xu, Yiying Liu, Huiyi Sun, Shanshan Lu, Yuan Ji, Jingjing Jiang, Yi Chen, Qiye He, Chengxiang Gong, Rui Liu, Zhixi Su, Yi Dong, Zhiping Yan and Lingxiao Liu
    Citation: BMC Medicine 2024 22:147
  3. Childhoods in urban or rural environments may differentially affect the risk of neuropsychiatric disorders, possibly through memory processing and neural response to emotional stimuli. Genetic factors may not ...

    Authors: Xiao Zhang, Yuyanan Zhang, Hao Yan, Hao Yu, Dai Zhang, Venkata S. Mattay, Hao Yang Tan and Weihua Yue
    Citation: BMC Medicine 2024 22:146
  4. Type 2 diabetes in young people is an aggressive disease with a greater risk of complications leading to increased morbidity and mortality during the most productive years of life. Prevalence in the UK and glo...

    Authors: Billy White, S. M. Ng, J. C. Agwu, T. G. Barrett, N. Birchmore, M. Kershaw, J. Drew, F. Kavvoura, J. Law, C. Moudiotis, E. Procter, P. Paul, F. Regan, P. Reilly, P. Sachdev, R. Sakremath…
    Citation: BMC Medicine 2024 22:144
  5. Temporary doctors, known as locums, are a key component of the medical workforce in the NHS but evidence on differences in quality and safety between locum and permanent doctors is limited. We aimed to examine...

    Authors: Christos Grigoroglou, Kieran Walshe, Evangelos Kontopantelis, Jane Ferguson, Gemma Stringer, Darren M. Ashcroft and Thomas Allen
    Citation: BMC Medicine 2024 22:126
  6. Syndromic surveillance often relies on patients presenting to healthcare. Community cohorts, although more challenging to recruit, could provide additional population-wide insights, particularly with SARS-CoV-...

    Authors: Elisabeth Dietz, Emma Pritchard, Koen Pouwels, Muhammad Ehsaan, Joshua Blake, Charlotte Gaughan, Eric Haduli, Hugh Boothe, Karina-Doris Vihta, Tim Peto, Nicole Stoesser, Philippa Matthews, Nick Taylor, Ian Diamond, Ruth Studley, Emma Rourke…
    Citation: BMC Medicine 2024 22:143
  7. Chronic graft-versus-host disease (cGVHD) is an immune-related disorder that is the most common complication post-allogenic hematopoietic stem cell transplant. Corticosteroids with or without calcineurin inhib...

    Authors: Ying Wang, Depei Wu, Xiang Zhang, Yuhua Li, Yanjie He, Qifa Liu, Li Xuan, Zhenyu Li, Kunming Qi, Yuqian Sun, Shunqing Wang, Wenjian Mo, Lei Gao, Ye Hua, Yu Wang and Ying Zhang
    Citation: BMC Medicine 2024 22:142
  8. Previous studies have shown that lifestyle/environmental factors could accelerate the development of age-related hearing loss (ARHL). However, there has not yet been a study investigating the joint association...

    Authors: Sang-Hyuk Jung, Young Chan Lee, Manu Shivakumar, Jaeyoung Kim, Jae-Seung Yun, Woong-Yang Park, Hong-Hee Won and Dokyoon Kim
    Citation: BMC Medicine 2024 22:141
  9. It is well-established that parental obesity is a strong risk factor for offspring obesity. Further, a converging body of evidence now suggests that maternal weight profiles may affect the developing offspring...

    Authors: Aylin Rosberg, Harri Merisaari, John D. Lewis, Niloofar Hashempour, Minna Lukkarinen, Jerod M. Rasmussen, Noora M. Scheinin, Linnea Karlsson, Hasse Karlsson and Jetro J. Tuulari
    Citation: BMC Medicine 2024 22:140
  10. The National Health Service in England aims to implement tobacco dependency treatment services in all hospitals by 2024. We aimed to assess the uptake of a new service, adapted from the Ottawa Model of Smoking...

    Authors: John Robins, Irem Patel, Ann McNeill, John Moxham, Arran Woodhouse, Gareth Absalom, Buljana Shehu, Geraldine Bruce, Amy Dewar, Alanna Molloy, Stephanie Duckworth Porras, Michael Waring, Andrew Stock and Debbie Robson
    Citation: BMC Medicine 2024 22:139
  11. Synaptic dysfunction with reduced synaptic protein levels is a core feature of Alzheimer’s disease (AD). Synaptic proteins play a central role in memory processing, learning, and AD pathogenesis. Evidence sugg...

    Authors: Huimin Cai, Yana Pang, Ziye Ren, Xiaofeng Fu and Longfei Jia
    Citation: BMC Medicine 2024 22:138
  12. Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), has been associated with several cancer risks in observational studies, but the observed associations have bee...

    Authors: Di Liu, Meiling Cao, Haotian Wang, Weijie Cao, Chenguang Zheng, Yun Li and Youxin Wang
    Citation: BMC Medicine 2024 22:137
  13. Despite the importance of medication adherence in treatment effectiveness, little is known about the association between medication non-adherence and self-inflicted violence behaviors. We aimed to assess wheth...

    Authors: Chuanlong Zuo, Xianmei Yang, Xiangrui Wu, Ruoxin Fan, Jun Liu, Hu Xiang, Yang Li, Xing Zhao, Xiang Liu and Yuanyuan Liu
    Citation: BMC Medicine 2024 22:136
  14. Childhood maltreatment is common globally and impacts morbidity, mortality, and well-being. Our understanding of its impact is constrained by key substantive and methodological limitations of extant research, ...

    Authors: Ana Lucia Espinosa Dice, Rebecca B. Lawn, Andrew Ratanatharathorn, Andrea L. Roberts, Christy A. Denckla, Ariel H. Kim, Pedro A. de la Rosa, Yiwen Zhu, Tyler J. VanderWeele and Karestan C. Koenen
    Citation: BMC Medicine 2024 22:135
  15. Alterations in sleep have been described in multiple health conditions and as a function of several medication effects. However, evidence generally stems from small univariate studies. Here, we apply a large-s...

    Authors: Péter Przemyslaw Ujma and Róbert Bódizs
    Citation: BMC Medicine 2024 22:134
  16. Sarcopenic obesity, a clinical and functional condition characterized by the coexistence of obesity and sarcopenia, has not been investigated in relation to dementia risk and its onset.

    Authors: Junhan Zhang, Xiaona Na, Zhihui Li, John S. Ji, Guowei Li, Haibing Yang, Yucheng Yang, Yuefeng Tan, Jian Zhang, Menglu Xi, Donghan Su, Huatang Zeng, Liqun Wu and Ai Zhao
    Citation: BMC Medicine 2024 22:133
  17. The impact of sodium intake on cardiovascular disease (CVD) health and mortality has been studied for decades, including the well-established association with blood pressure. However, non-linear patterns, dose...

    Authors: Lu Gan, Bin Zhao, Maki Inoue-Choi, Linda M. Liao, Barry I. Graubard, Stephanie J. Weinstein, Demetrius Albanes and Jiaqi Huang
    Citation: BMC Medicine 2024 22:132
  18. Pandemics and climate change each challenge health systems through increasing numbers and new types of patients. To adapt to these challenges, leading health systems have embraced a Learning Health System (LHS...

    Authors: Carolynn L. Smith, Georgia Fisher, Putu Novi Arfirsta Dharmayani, Shalini Wijekulasuriya, Louise A. Ellis, Samantha Spanos, Genevieve Dammery, Yvonne Zurynski and Jeffrey Braithwaite
    Citation: BMC Medicine 2024 22:131
  19. Comprehensive data on patients at high risk of sudden cardiac death (SCD) in emerging countries are lacking. The aim was to deepen our understanding of the SCD phenotype and identify risk factors for death amo...

    Authors: Shuang Zhao, Chi-Keong Ching, Dejia Huang, Yen-Bin Liu, Diego A. Rodriguez-Guerrero, Azlan Hussin, Young-Hoon Kim, Brian Van Dorn, Xiaohong Zhou, Balbir Singh and Shu Zhang
    Citation: BMC Medicine 2024 22:130
  20. There is a growing population of children with in utero HIV exposure who are at risk of poor neurodevelopmental outcomes despite avoiding HIV infection. However, the underlying neurobiological pathways are not...

    Authors: Catherine J. Wedderburn, Shunmay Yeung, Sivenesi Subramoney, Jean-Paul Fouche, Shantanu H. Joshi, Katherine L. Narr, Andrea M. Rehman, Annerine Roos, Diana M. Gibb, Heather J. Zar, Dan J. Stein and Kirsten A. Donald
    Citation: BMC Medicine 2024 22:129
  21. Authors: Naomi R. Waterlow, Jackie Kleynhans, Nicole Wolter, Stefano Tempia, Rosalind M. Eggo, Orienka Hellferscee, Limakatso Lebina, Neil Martinson, Ryan G. Wagner, Jocelyn Moyes, Anne von Gottberg, Cheryl Cohen and Stefan Flasche
    Citation: BMC Medicine 2024 22:128

    The original article was published in BMC Medicine 2023 21:441

  22. While the augmented incidence of diabetes after COVID-19 has been widely confirmed, controversial results are available on the risk of developing hypertension during the COVID-19 pandemic.

    Authors: Valentina Trimarco, Raffaele Izzo, Daniela Pacella, Ugo Trama, Maria Virginia Manzi, Angela Lombardi, Roberto Piccinocchi, Paola Gallo, Giovanni Esposito, Gaetano Piccinocchi, Maria Lembo, Carmine Morisco, Francesco Rozza, Gaetano Santulli and Bruno Trimarco
    Citation: BMC Medicine 2024 22:127
  23. Highlighted by the rise of COVID-19, climate change, and conflict, socially vulnerable populations are least resilient to disaster. In infectious disease management, mathematical models are a commonly used too...

    Authors: Megan Naidoo, Whitney Shephard, Innocensia Kambewe, Nokuthula Mtshali, Sky Cope, Felipe Alves Rubio and Davide Rasella
    Citation: BMC Medicine 2024 22:125
  24. Several neurological manifestations shortly after a receipt of coronavirus infectious disease 2019 (COVID-19) vaccine have been described in the recent case reports. Among those, we sought to evaluate the risk...

    Authors: Ju Hwan Kim, Dongwon Yoon, Hwa Yeon Ko, Kyungyeon Jung, Jun-Sang Sunwoo, Won Chul Shin, Jung-Ick Byun and Ju-Young Shin
    Citation: BMC Medicine 2024 22:123
  25. Patients with fibro-calcific aortic valve disease (FCAVD) have lipid depositions in their aortic valve that engender a proinflammatory impetus toward fibrosis and calcification and ultimately valve leaflet ste...

    Authors: Dohee Yoon, Bongkun Choi, Ji-Eun Kim, Eun-Young Kim, Soo-Hyun Chung, Hyo-Jin Min, Yoolim Sung, Eun-Ju Chang and Jae-Kwan Song
    Citation: BMC Medicine 2024 22:122

    The Correction to this article has been published in BMC Medicine 2024 22:178

  26. Socio-emotional impairments are among the diagnostic criteria for autism spectrum disorder (ASD), but the actual knowledge has substantiated both altered and intact emotional prosodies recognition. Here, a Bay...

    Authors: Mathilde Marie Duville, Luz María Alonso-Valerdi and David I. Ibarra-Zarate
    Citation: BMC Medicine 2024 22:121
  27. Numerous observational studies have highlighted associations of genetic predisposition of head and neck squamous cell carcinoma (HNSCC) with diverse risk factors, but these findings are constrained by design l...

    Authors: Young Chan Lee, Sang-Hyuk Jung, Manu Shivakumar, Soojin Cha, Woong-Yang Park, Hong-Hee Won, Young-Gyu Eun, Penn Medicine Biobank and Dokyoon Kim
    Citation: BMC Medicine 2024 22:120
  28. Intravenous leiomyomatosis (IVL), pulmonary benign metastatic leiomyomatosis (PBML), and leiomyomatosis peritonealis disseminata (LPD) are leiomyomas with special growth patterns and high postoperative recurre...

    Authors: Guorui Zhang, Rong Fan, Hua Yang, Hao Su, Xin Yu, Yutong Wang, Fengzhi Feng and Lan Zhu
    Citation: BMC Medicine 2024 22:119
  29. Few previous studies have assessed overall morbidity at the individual level with respect to future risk of hip fracture. The aim of this register-based cohort study was to examine the association between morb...

    Authors: Siri Marie Solbakken, Haakon Eduard Meyer, Cecilie Dahl, Trine Elisabeth Finnes, Vidar Hjellvik, Christopher Sivert Nielsen, Tone Kristin Omsland, Hein Stigum and Kristin Holvik
    Citation: BMC Medicine 2024 22:118
  30. Paxlovid has been shown to be effective in reducing mortality and hospitalization rates in patients with coronavirus disease 2019 (COVID-19). It is not known whether Paxlovid can reduce the risk of cardiovascu...

    Authors: Weijie Wang, Yu-Hsun Wang, Ching-Hua Huang, Tsung-Hsueh Hsieh, Gema Hernández Ibarburu and James Cheng-Chung Wei
    Citation: BMC Medicine 2024 22:117
  31. Experiences during childhood and adolescence have enduring impacts on physical and mental well-being, overall quality of life, and socioeconomic status throughout one’s lifetime. This underscores the importanc...

    Authors: Chengchen Duan, Liu Liu, Tianyi Wang, Guanru Wang, Zhishen Jiang, Honglin Li, Gaowei Zhang, Li Ye, Chunjie Li and Yubin Cao
    Citation: BMC Medicine 2024 22:116
  32. The global dementia prevalence is surging, necessitating research into contributing factors. We aimed to investigate the association between metabolic syndrome (MetS), its components, serum uric acid (SUA) lev...

    Authors: Tara SR Chen, Ning-Ning Mi, Hubert Yuenhei Lao, Chen-Yu Wang, Wai Leung Ambrose Lo, Yu-Rong Mao, Yan Tang, Zhong Pei, Jin-Qiu Yuan and Dong-Feng Huang
    Citation: BMC Medicine 2024 22:115
  33. Type 2 diabetes (T2D) is associated with an increased risk of premature death. Whether multifactorial risk factor modification could attenuate T2D-related excess risk of death is unclear. We aimed to examine t...

    Authors: Bin Wang, Yanqi Fu, Xiao Tan, Ningjian Wang, Lu Qi and Yingli Lu
    Citation: BMC Medicine 2024 22:114
  34. In post-stroke atrial fibrillation (AF) patients who have indications for both oral anticoagulant (OAC) and antiplatelet agent (AP), e.g., those with carotid artery stenosis, there is debate over the best anti...

    Authors: Chuan-Tsai Tsai, Yi-Hsin Chan, Jo-Nan Liao, Tzeng-Ji Chen, Gregory Y. H. Lip, Shih-Ann Chen and Tze-Fan Chao
    Citation: BMC Medicine 2024 22:113
  35. The transitivity assumption is the cornerstone of network meta-analysis (NMA). Violating transitivity compromises the credibility of the indirect estimates and, by extent, the estimated treatment effects of th...

    Authors: Loukia M. Spineli, Chrysostomos Kalyvas, Juan Jose Yepes-Nuñez, Andrés Mauricio García-Sierra, Diana C. Rivera-Pinzón, Svenja E. Seide and Katerina Papadimitropoulou
    Citation: BMC Medicine 2024 22:112
  36. Previous randomized controlled trials (RCTs) suggested that gut microbiota-based therapies may be effective in treating autoimmune diseases, but a systematic summary is lacking.

    Authors: Liuting Zeng, Kailin Yang, Qi He, Xiaofei Zhu, Zhiyong Long, Yang Wu, Junpeng Chen, Yuwei Li, Jinsong Zeng, Ge Cui, Wang Xiang, Wensa Hao and Lingyun Sun
    Citation: BMC Medicine 2024 22:110
  37. Omega-3 polyunsaturated fatty acids (n-3 PUFA) have been suggested as a cognitive enhancing agent, though their effect is doubtful. We aimed to examine the effect of n-3 PUFA on the cognitive function of middl...

    Authors: Seung Wan Suh, Eunji Lim, Suh-Yuhn Burm, Hyungji Lee, Jong Bin Bae, Ji Won Han and Ki Woong Kim
    Citation: BMC Medicine 2024 22:109
  38. The emergence of new SARS-CoV-2 variants and the waning of immunity raise concerns about vaccine effectiveness and protection against COVID-19. While antibody response has been shown to correlate with the risk...

    Authors: Carla Martín Pérez, Ruth Aguilar, Alfons Jiménez, Gemma Salmerón, Mar Canyelles, Rocío Rubio, Marta Vidal, Inocencia Cuamba, Diana Barrios, Natalia Díaz, Rebeca Santano, Pau Serra, Pere Santamaria, Luis Izquierdo, Antoni Trilla, Anna Vilella…
    Citation: BMC Medicine 2024 22:103
  39. Diabetes patients are at higher risk for mortality than the general population; however, little is known about whether the excess mortality risk associated with diabetes could be mitigated or nullified via con...

    Authors: Jian Zhou, Xuan Wang, Rui Tang, Minghao Kou, Hao Ma, Xiang Li, Yoriko Heianza, Vivian Fonseca and Lu Qi
    Citation: BMC Medicine 2024 22:108
  40. Classical Hodgkin lymphoma (cHL) is a highly curable disease, while novel therapy is needed for refractory or relapsed (R/R) patients. This phase II trial aimed to evaluate the role of camrelizumab plus gemcit...

    Authors: Yanfei Liu, Lingyan Ping, Yuqin Song, Yongjing Tang, Wen Zheng, Weiping Liu, Zhitao Ying, Chen Zhang, Meng Wu, Feier Feng, Ningjing Lin, Meifeng Tu, Jun Zhu and Yan Xie
    Citation: BMC Medicine 2024 22:107
  41. The relaxation of the “zero-COVID” policy on Dec. 7, 2022, in China posed a major public health threat recently. Complete blood count test was discovered to have complicated relationships with COVID-19 after t...

    Authors: Yifei Lin, Yong Yang, Nanyan Xiang, Le Wang, Tao Zheng, Xuejun Zhuo, Rui Shi, Xiaoyi Su, Yan Liu, Ga Liao, Liang Du and Jin Huang
    Citation: BMC Medicine 2024 22:105
  42. The specific microbiota and associated metabolites linked to non-alcoholic fatty liver disease (NAFLD) are still controversial. Thus, we aimed to understand how the core gut microbiota and metabolites impact N...

    Authors: Fangfang Zeng, Xin Su, Xinxiu Liang, Minqi Liao, Haili Zhong, Jinjian Xu, Wanglong Gou, Xiangzhou Zhang, Luqi Shen, Ju-Sheng Zheng and Yu-ming Chen
    Citation: BMC Medicine 2024 22:104
  43. Empirical evidence suggests that lack of blinding may be associated with biased estimates of treatment benefit in randomized controlled trials, but the influence on medication-related harms is not well-recogni...

    Authors: Chang Xu, Fengying Zhang, Suhail A. R. Doi, Luis Furuya-Kanamori, Lifeng Lin, Haitao Chu, Xi Yang, Sheyu Li, Liliane Zorzela, Su Golder, Yoon Loke and Sunita Vohra
    Citation: BMC Medicine 2024 22:83
  44. Effectively managing the coexistence of both diabetes and disability necessitates substantial effort. Whether disability onset affects adherence to type 2 diabetes medication remains unclear. This study invest...

    Authors: Szu-Han Chen, Miaw-Chwen Lee and Christy Pu
    Citation: BMC Medicine 2024 22:102
  45. Non-alcoholic fatty liver disease (NAFLD) and metabolic-associated fatty liver disease (MAFLD) shares common pathophysiological mechanisms with type 2 diabetes, making them significant risk factors for type 2 ...

    Authors: Limin Cao, Yu An, Huiyuan Liu, Jinguo Jiang, Wenqi Liu, Yuhan Zhou, Mengyuan Shi, Wei Dai, Yanling Lv, Yuhong Zhao, Yanhui Lu, Liangkai Chen and Yang Xia
    Citation: BMC Medicine 2024 22:101
  46. In 2021, whilst societies were emerging from major social restrictions during the SARS-CoV-2 pandemic, the UK government instigated an Events Research Programme to examine the risk of COVID-19 transmission fro...

    Authors: Ian J. Douglas, Jerlyn Peh, Kathryn E. Mansfield, Anna Trelfa, Tom Fowler, Matthew Boulter, Paul Cleary, Jenifer Smith and W. John Edmunds
    Citation: BMC Medicine 2024 22:100
  47. The key role of thrombospondin 1 (THBS1) in the pathogenesis of acute-on-chronic liver failure (ACLF) is unclear. Here, we present a transcriptome approach to evaluate THBS1 as a potential biomarker in ACLF di...

    Authors: Hozeifa Mohamed Hassan, Xi Liang, Jiaojiao Xin, Yingyan Lu, Qun Cai, Dongyan Shi, Keke Ren, Jun Li, Qi Chen, Jiang Li, Peng Li, Beibei Guo, Hui Yang, Jinjin Luo, Heng Yao, Xingping Zhou…
    Citation: BMC Medicine 2024 22:95