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  1. The pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) of breast cancer is closely related to a better prognosis. However, there are no reliable indicators to accurately identify which pati...

    Authors: Zhaoyun Liu, Bo Yu, Mu Su, Chenxi Yuan, Cuicui Liu, Xinzhao Wang, Xiang Song, Chao Li, Fukai Wang, Jianli Ma, Meng Wu, Dawei Chen, Jinming Yu and Zhiyong Yu
    Citation: BMC Medicine 2023 21:493
  2. Globally, detections of carbapenemase-producing Enterobacterales (CPE) colonisations and infections are increasing. The spread of these highly resistant bacteria poses a serious threat to public health. Howeve...

    Authors: Diane Pople, Theodore Kypraios, Tjibbe Donker, Nicole Stoesser, Anna C. Seale, Ryan George, Andrew Dodgson, Rachel Freeman, Russell Hope, Ann Sarah Walker, Susan Hopkins and Julie Robotham
    Citation: BMC Medicine 2023 21:492
  3. Major psychiatric disorders such as schizophrenia (SCZ) and bipolar disorder (BPD) are complex genetic mental illnesses. Their non-Mendelian features, such as those observed in monozygotic twins discordant for...

    Authors: Junping Ye, Zhanwang Huang, Qiyang Li, Zhongwei Li, Yuting Lan, Zhongju Wang, Chaoying Ni, Xiaohui Wu, Tingyun Jiang, Yujing Li, Qiong Yang, Junghwa Lim, Cun-Yan Ren, Meijun Jiang, Shufen Li, Peng Jin…
    Citation: BMC Medicine 2023 21:491
  4. Olfactory disorders are common in COVID-19. While many patients recover within weeks, a notable number of patients suffer from prolonged olfactory disorders. Much research has focused on the acute phase of olf...

    Authors: Emma J. A. Schepens, Wilbert M. Boek, Sanne Boesveldt, Robert J. Stokroos, Inge Stegeman and Digna M. A. Kamalski
    Citation: BMC Medicine 2023 21:490
  5. Pancreatic cancer (PC) is influenced by both genetic and lifestyle factors. However, further research is still needed to comprehensively clarify the relationships among lifestyle, genetic factors, their combin...

    Authors: Liangtang Zeng, Zhuo Wu, Jiabin Yang, Yu Zhou and Rufu Chen
    Citation: BMC Medicine 2023 21:489
  6. Preliminary evidence demonstrates some parameters of metabolic control, including glycaemic control, lipid control and insulin resistance, vary across the menstrual cycle. However, the literature is inconsiste...

    Authors: Kirstin A. MacGregor, Frederick K. Ho, Carlos A. Celis-Morales, Jill P. Pell, Iain J. Gallagher and Colin N. Moran
    Citation: BMC Medicine 2023 21:488
  7. Glioma is one of the leading types of brain tumor, but few etiologic factors of primary glioma have been identified. Previous observational research has shown an association between viral infection and glioma ...

    Authors: Sheng Zhong, Wenzhuo Yang, Zhiyun Zhang, Yangyiran Xie, Lin Pan, Jiaxin Ren, Fei Ren, Yifan Li, Haoqun Xie, Hongyu Chen, Davy Deng, Jie Lu, Hui Li, Bo Wu, Youqi Chen, Fei Peng…
    Citation: BMC Medicine 2023 21:487
  8. A protracted Ebola Virus Disease (EVD) epidemic in the eastern Ituri, North and South Kivu provinces of the Democratic Republic of Congo (DRC) caused 3470 confirmed and probable cases between July 2018 and Apr...

    Authors: Abdihamid Warsame, Gwendolen Eamer, Alaria Kai, Lucia Robles Dios, Hana Rohan, Patrick Keating, Jacques Katshishi and Francesco Checchi
    Citation: BMC Medicine 2023 21:484
  9. Whether a low-inflammatory diet relates to type 2 diabetes risk remains unclear. We examined the association between a low-inflammatory diet and risk of type 2 diabetes among normoglycemic and prediabetic part...

    Authors: Rongrong Yang, Jing Lin, Hongxi Yang, Michelle M. Dunk, Jiao Wang, Weili Xu and Yaogang Wang
    Citation: BMC Medicine 2023 21:483
  10. Endometriosis affects 1 in 9 women, yet it is poorly understood with long diagnostic delays, invasive diagnoses, and poor treatment outcomes. Characterised by the presence of endometrial-like tissue outside of...

    Authors: Isabelle M. McGrath, Grant W. Montgomery and Sally Mortlock
    Citation: BMC Medicine 2023 21:482
  11. Microvascular invasion (MVI) is the main factor affecting the prognosis of patients with hepatocellular carcinoma (HCC). The aim of this study was to identify accurate diagnostic biomarkers from urinary protei...

    Authors: Yaru Wang, Bo Meng, Xijun Wang, Anke Wu, Xiaoyu Li, Xiaohong Qian, Jianxiong Wu, Wantao Ying, Ting Xiao and Weiqi Rong
    Citation: BMC Medicine 2023 21:481
  12. Few studies have directly compared the risk and magnitude of post-acute sequelae following COVID-19 and influenza, and most of these studies were conducted before emergence of the Omicron. This study investiga...

    Authors: Ting-Hui Liu, Po-Yu Huang, Jheng-Yan Wu, Min-Hsiang Chuang, Wan-Hsuan Hsu, Ya-Wen Tsai and Chih-Cheng Lai
    Citation: BMC Medicine 2023 21:480
  13. This study aimed to investigate the neuroanatomical subtypes among early-onset schizophrenia (EOS) patients by exploring the association between structural alterations and molecular mechanisms using a combined...

    Authors: Guanqun Yao, Ting Zou, Jing Luo, Shuang Hu, Langxiong Yang, Jing Li, Xinrong Li, Yuqi Zhang, Kun Feng, Yong Xu and Pozi Liu
    Citation: BMC Medicine 2023 21:479
  14. The association between the vaginal microbiome and polycystic ovary syndrome (PCOS) is reported, but the longitudinal changes in the vaginal microbiome that accompany oral contraceptive therapy have not been d...

    Authors: Xiang Hong, Pengfei Qin, Liting Gao, Lingling Huang, Yong Shi, Danhong Peng and Bei Wang
    Citation: BMC Medicine 2023 21:478
  15. As a professional group, physicians are at increased risk of burnout and job stress, both of which are associated with an increased risk of coronary heart disease that is at least as high as that of other prof...

    Authors: Roland von Känel, Mary Princip, Sarah A. Holzgang, Chrysoula Garefa, Alexia Rossi, Dominik C. Benz, Andreas A. Giannopoulos, Philipp A. Kaufmann, Ronny R. Buechel, Claudia Zuccarella-Hackl and Aju P. Pazhenkottil
    Citation: BMC Medicine 2023 21:477

    The Correction to this article has been published in BMC Medicine 2024 22:71

  16. Intra-tumour heterogeneity (ITH) presents a significant obstacle in formulating effective treatment strategies in clinical practice. Single-cell RNA sequencing (scRNA-seq) has evolved as a powerful instrument ...

    Authors: Simona Pellecchia, Gaetano Viscido, Melania Franchini and Gennaro Gambardella
    Citation: BMC Medicine 2023 21:476

    The Correction to this article has been published in BMC Medicine 2024 22:70

  17. Healthcare workers’ (HCW) well-being has a direct effect on patient care. However, little is known about the prevalence and patterns of long-term medical conditions in HCWs, especially those from ethnic minori...

    Authors: Winifred Ekezie, Christopher A. Martin, Rebecca F. Baggaley, Lucy Teece, Joshua Nazareth, Daniel Pan, Shirley Sze, Luke Bryant, Katherine Woolf, Laura J. Gray, Kamlesh Khunti and Manish Pareek
    Citation: BMC Medicine 2023 21:433
  18. The results of clinical trials should be completely and rapidly reported during public health emergencies such as COVID-19. This study aimed to examine when, and where, the results of COVID-19 clinical trials ...

    Authors: Maia Salholz-Hillel, Molly Pugh-Jones, Nicole Hildebrand, Tjada A. Schult, Johannes Schwietering, Peter Grabitz, Benjamin Gregory Carlisle, Ben Goldacre, Daniel Strech and Nicholas J. DeVito
    Citation: BMC Medicine 2023 21:475
  19. Sodium bicarbonate (SB) infusion is commonly used to correct metabolic acidosis, but its clinical efficacy remains controversial. This study aims to investigate whether acid–base balance parameters should be a...

    Authors: Huaqing Liu, Yanmei Cao, Xiaoyan Xue, Zhenjiang Bai and Shuiyan Wu
    Citation: BMC Medicine 2023 21:473
  20. Increasing maternal glycaemia across the continuum during pregnancy may predispose offspring to subsequent cardiometabolic risk later in life. However, evidence of long-term impacts of maternal glycemic status...

    Authors: Mengjiao Liu, Shiao-Yng Chan, Johan G. Eriksson, Yap Seng Chong, Yung Seng Lee, Fabian Yap, Mary Foong-Fong Chong, Mya Thway Tint, Jiaxi Yang, David Burgner, Cuilin Zhang and Ling-Jun Li
    Citation: BMC Medicine 2023 21:472
  21. There are increasing concerns that participants in health research in the UK are not representative of the UK population, risking widening health inequities. However, detailed information on the magnitude of t...

    Authors: Kathryn M. Abel, Maja R. Radojčić, Archie Rayner, Rabia Butt, Pauline Whelan, Isaac Parr, Lauren F. Gledhill, Ashley Minchin, Peter Bower and Holly Hope
    Citation: BMC Medicine 2023 21:471
  22. Cell-based  immunotherapy shows the therapeutic potential in sarcomas, in addition to angiogenesis-targeted tyrosine kinase inhibitor (TKI) and immune checkpoint inhibitor (ICI). Multi-antigen stimulated cell ...

    Authors: Yan Zhou, Mei Li, Bing Zhang, Cheng Yang, Yaling Wang, Shuier Zheng, Lina Tang, Chenliang Zhou, Guowei Qian, Yujing Huang, Wenxi Yu, Hongtao Li, Yonggang Wang, Aina He, Zan Shen, Jianjun Zhang…
    Citation: BMC Medicine 2023 21:470
  23. Emerging metabolomics-based studies suggested links between amino acid metabolism and metabolic dysfunction-associated fatty liver disease (MAFLD) risk; however, whether there exists an aetiological role of am...

    Authors: Jian Zhao, Jing Zeng, Cairong Zhu, Xuechao Li, Dong Liu, Jun Zhang, Fei Li, Giovanni Targher and Jian-Gao Fan
    Citation: BMC Medicine 2023 21:469
  24. Prior reviews synthesized findings of studies on long-term cardiac complications of COVID-19. However, the reporting and methodological quality of these studies has not been systematically evaluated. Here, we ...

    Authors: Boya Guo, Chenya Zhao, Mike Z. He, Camilla Senter, Zhenwei Zhou, Jin Peng, Song Li, Annette L. Fitzpatrick, Sara Lindström, Rebecca C. Stebbins, Grace A. Noppert and Chihua Li
    Citation: BMC Medicine 2023 21:468
  25. The World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) Cancer Prevention Recommendations are lifestyle-based recommendations which aim to reduce cancer risk. This study investigate...

    Authors: Fiona C. Malcomson, Solange Parra-Soto, Frederick K. Ho, Liya Lu, Carlos Celis-Morales, Linda Sharp and John C. Mathers
    Citation: BMC Medicine 2023 21:407

    The Comment to this article has been published in BMC Global and Public Health 2024 2:7

  26. This reconstructed individual patient data (IPD)-based meta-analysis is aimed to summarize the current findings and comprehensively investigate the predictive value of circulating tumor DNA (ctDNA) in operable...

    Authors: Dali Chen, Jinbao Guo, Hao Huang, Lei Tian, Yunbo Xie and Qingchen Wu
    Citation: BMC Medicine 2023 21:467
  27. Each mother–child dyad represents a unique combination of genetic and environmental factors. This constellation of variables impacts the expression of countless genes. Numerous studies have uncovered changes i...

    Authors: Jane W. Y. Ng, Janine F. Felix and David M. Olson
    Citation: BMC Medicine 2023 21:466
  28. Post-radiation nasopharyngeal necrosis (PRNN) is a severe adverse event following re-radiotherapy for patients with locally recurrent nasopharyngeal carcinoma (LRNPC) and associated with decreased survival. Bi...

    Authors: Ting Liu, Di Dong, Xun Zhao, Xiao-Min Ou, Jun-Lin Yi, Jian Guan, Ye Zhang, Lv Xiao-Fei, Chuan-Miao Xie, Dong-Hua Luo, Rui Sun, Qiu-Yan Chen, Lv Xing, Shan-Shan Guo, Li-Ting Liu, Da-Feng Lin…
    Citation: BMC Medicine 2023 21:464

    The Commentary to this article has been published in BMC Medicine 2023 21:465

  29. High rates of discontinuation undermine the effectiveness of adjuvant endocrine therapy (AET) among hormone-receptive breast cancer patients. Patient prognosis also relies on the successful management of cardi...

    Authors: Juliette Artignan, Perrine Capmas, Henri Panjo, Panayotis Constantinou and Nathalie Pelletier-Fleury
    Citation: BMC Medicine 2023 21:463
  30. High-power short-duration (HPSD) ablation strategy has emerged as a popular approach for treating atrial fibrillation (AF), with shorter ablation time. The utilized Smart Touch Surround Flow (STSF) catheter, w...

    Authors: Wei-Jie Chen, Chun-Xia Gan, Yang-Wei Cai, Yang-Yang Liu, Pei-Lin Xiao, Li-Li Zou, Qing-Song Xiong, Fang Qin, Xie-Xin Tao, Ran Li, Hua-An Du, Zeng-Zhang Liu, Yue-Hui Yin and Zhi-Yu Ling
    Citation: BMC Medicine 2023 21:461
  31. Endometriosis is a common, gynaecological disease characterised by the presence of endometrial-like cells growing outside the uterus. Lesions appear at multiple locations, present with variation in appearance,...

    Authors: Sushma Marla, Sally Mortlock, Taija Heinosalo, Matti Poutanen, Grant W. Montgomery and Brett David McKinnon
    Citation: BMC Medicine 2023 21:460
  32. AD16 is a Class 1.1 new drug candidate for Alzheimer’s disease (AD), which has demonstrated potential benefits in AD by reducing neuroinflammation in preclinical studies. Herein, the pharmacokinetics (PK), saf...

    Authors: Daizhuang Peng, Sumei Xu, Ting Zou, Yahui Wang, Wenjuan Ouyang, Yalan Zhang, Chengmei Dong, Dai Li, Jie Guo, Qiuying Shen, Xiaolei Hu, Wenzhi Zhou, Xiaomin Li and Qun Qin
    Citation: BMC Medicine 2023 21:459
  33. Circulating extracellular vesicles (EVs) are increased in preeclampsia (PE) and are associated with severity and progression. We examined in this exploratory cohort study if the mRNAs and long noncoding RNAs (...

    Authors: Tove Lekva, Arvind Y.FM. Sundaram, Marie Cecilie Paasche Roland, June Åsheim, Annika E. Michelsen, Errol R. Norwitz, Pål Aukrust, Gregor D. Gilfillan and Thor Ueland
    Citation: BMC Medicine 2023 21:458
  34. Sex difference exists in the prevalence of dementia and cognitive decline. The impacts of sex-specific reproductive risk factors across the lifespan on the risk of dementia or cognitive decline are still uncle...

    Authors: Shuang-Ling Han, De-Chun Liu, Chen-Chen Tan, Lan Tan and Wei Xu
    Citation: BMC Medicine 2023 21:457
  35. The European Society of Intensive Care Medicine (ESICM) recently recommended changes to the criteria of acute respiratory distress syndrome (ARDS), patients with high-flow oxygen were included, however, the ef...

    Authors: Lina Zhao, Fuhong Su, Nannan Zhang, Hening Wu, Yuehao Shen, Haiying Liu, Xuguang Li, Yun Li and Keliang Xie
    Citation: BMC Medicine 2023 21:456
  36. Selective fetal growth restriction (sFGR) is an extreme complication that significantly increases the risk of perinatal mortality and long-term adverse neurological outcomes in offspring, affecting approximate...

    Authors: Nana Huang, Wei Chen, Hai Jiang, Jing Yang, Youzhen Zhang, Huifeng Shi, Ying Wang, Pengbo Yuan, Jie Qiao, Yuan Wei and Yangyu Zhao
    Citation: BMC Medicine 2023 21:455
  37. Whether cancer risk associated with a higher body mass index (BMI), a surrogate measure of adiposity, differs among adults with and without cardiovascular diseases (CVD) and/or type 2 diabetes (T2D) is unclear...

    Authors: Emma Fontvieille, Vivian Viallon, Martina Recalde, Reynalda Cordova, Anna Jansana, Laia Peruchet-Noray, Hannah Lennon, Alicia K. Heath, Dagfinn Aune, Sofia Christakoudi, Verena Katzke, Rudolf Kaaks, Elif Inan-Eroglu, Matthias B. Schulze, Lene Mellemkjær, Anne Tjønneland…
    Citation: BMC Medicine 2023 21:418
  38. The progression of sleep disturbances remains unclear in patients with early multiple system atrophy (MSA). We aimed to explore the frequency, severity, and coexistence of 2-year longitudinal changes of sleep ...

    Authors: Lingyu Zhang, Yanbing Hou, Chunyu Li, Qianqian Wei, Ruwei Ou, Kuncheng Liu, Junyu Lin, Tianmi Yang, Yi Xiao, Qirui Jiang, Bi Zhao and Huifang Shang
    Citation: BMC Medicine 2023 21:454
  39. The epididymis is crucial for post-testicular sperm development which is termed sperm maturation. During this process, fertilizing ability is acquired through the epididymis-sperm communication via exchange of...

    Authors: Zhuoyao Ma, Jinyu Li, Li Fu, Rong Fu, Ningyuan Tang, Yanmei Quan, Zhixiang Xin, Zhide Ding and Yue Liu
    Citation: BMC Medicine 2023 21:453
  40. Emerging research suggests that attention-deficit/hyperactivity disorder (ADHD) increases the risk for cardiovascular (CVDs) and metabolic disorders (i.e., cardiometabolic disorders) in adulthood. Yet, availab...

    Authors: Maja Dobrosavljevic, Ralf Kuja-Halkola, Lin Li, Zheng Chang, Henrik Larsson and Ebba Du Rietz
    Citation: BMC Medicine 2023 21:452
  41. Widely adopted criteria suggest using either low handgrip strength or poor chair stand performance to identify probable sarcopenia. However, there are limited direct comparisons of these measures in relation t...

    Authors: Jonas Johansson, Sameline Grimsgaard, Bjørn Heine Strand, Avan A. Sayer and Rachel Cooper
    Citation: BMC Medicine 2023 21:451
  42. Leveraging a large nationwide study of Icelandic women, we aimed to narrow the evidence gap around female attention-deficit/hyperactivity disorder (ADHD) and cardiometabolic comorbidities by determining the pr...

    Authors: Unnur Jakobsdottir Smari, Unnur Anna Valdimarsdottir, Thor Aspelund, Arna Hauksdottir, Edda Bjork Thordardottir, Catharina A. Hartman, Pontus Andell, Henrik Larsson and Helga Zoega
    Citation: BMC Medicine 2023 21:450
  43. The immunologic milieu at the maternal–fetal interface has profound effects on propelling the development of the fetal brain. However, accessible epidemiological studies concerning the association between plac...

    Authors: Jixing Zhou, Juan Tong, Xue Ru, Yuzhu Teng, Menglong Geng, Shuangqin Yan, Fangbiao Tao and Kun Huang
    Citation: BMC Medicine 2023 21:449
  44. Acquired brain injury (ABI) is linked to increased depression risk. Existing therapies for depression in ABI (e.g., cognitive behavioural therapy) have mixed efficacy. Behavioural activation (BA), an intervent...

    Authors: Andrea Kusec, Fionnuala C. Murphy, Polly V. Peers, Ron Bennett, Estela Carmona, Aleksandra Korbacz, Cara Lawrence, Emma Cameron, Andrew Bateman, Peter Watson, Judith Allanson, Pieter duToit and Tom Manly
    Citation: BMC Medicine 2023 21:445
  45. Excess energy intake can lead to metabolic dysfunction-associated steatotic liver disease (MASLD), but the relationship between dietary carbohydrate intake and liver fat content remains unclear. This study aim...

    Authors: Josefina Orliacq, Aurora Pérez-Cornago, Siôn A Parry, Rebecca K Kelly, Dimitrios A Koutoukidis and Jennifer L Carter
    Citation: BMC Medicine 2023 21:444
  46. There is growing evidence that substituting animal-based with plant-based foods is associated with a lower risk of cardiovascular diseases (CVD), type 2 diabetes (T2D), and all-cause mortality. Our aim was to ...

    Authors: Manuela Neuenschwander, Julia Stadelmaier, Julian Eble, Kathrin Grummich, Edyta Szczerba, Eva Kiesswetter, Sabrina Schlesinger and Lukas Schwingshackl
    Citation: BMC Medicine 2023 21:404

    The Comment to this article has been published in BMC Global and Public Health 2024 2:3