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  1. There is currently a lack of effective treatments for non-small cell lung cancer (NSCLC) patients harboring HER2 mutations. We examined the efficacy and safety of, and potential resistance mechanism to, pyrotinib...

    Authors: Zhengbo Song, Yuping Li, Shiqing Chen, Shenpeng Ying, Shuguang Xu, Jianjin Huang, Dan Wu, Dongqing Lv, Ting Bei, Shuxun Liu, Xiaoping Huang, Congying Xie, Xiaoyu Wu, Jianfei Fu, Feng Hua, Wenxian Wang…
    Citation: BMC Medicine 2022 20:42
  2. Cabazitaxel improves overall survival (OS) in metastatic castration-resistant prostate cancer (mCRPC) patients progressing after docetaxel. In this prospective study, we evaluated the prognostic role of CTC ge...

    Authors: Giorgia Gurioli, Vincenza Conteduca, Nicole Brighi, Emanuela Scarpi, Umberto Basso, Giuseppe Fornarini, Alessandra Mosca, Maurizio Nicodemo, Giuseppe Luigi Banna, Cristian Lolli, Giuseppe Schepisi, Giorgia Ravaglia, Isabella Bondi, Paola Ulivi and Ugo De Giorgi
    Citation: BMC Medicine 2022 20:48
  3. Human papilloma virus infection is known to influence oropharyngeal cancer (OPC) risk, likely via sexual transmission. However, sexual behaviour has been correlated with other risk factors including smoking an...

    Authors: Mark Gormley, Tom Dudding, Linda Kachuri, Kimberley Burrows, Amanda H. W. Chong, Richard M. Martin, Steven J. Thomas, Jessica Tyrrell, Andrew R. Ness, Paul Brennan, Marcus R. Munafò, Miranda Pring, Stefania Boccia, Andrew F. Olshan, Brenda Diergaarde, Rayjean J. Hung…
    Citation: BMC Medicine 2022 20:40
  4. To allow a return to a pre-COVID-19 lifestyle, virtually every country has initiated a vaccination program to mitigate severe disease burden and control transmission. However, it remains to be seen whether her...

    Authors: Hengcong Liu, Juanjuan Zhang, Jun Cai, Xiaowei Deng, Cheng Peng, Xinghui Chen, Juan Yang, Qianhui Wu, Xinhua Chen, Zhiyuan Chen, Wen Zheng, Cécile Viboud, Wenhong Zhang, Marco Ajelli and Hongjie Yu
    Citation: BMC Medicine 2022 20:37
  5. Metabolic syndrome (MetS) is a risk factor in surgery. MetS can progress to metabolic (dysfunction)-associated fatty liver disease (MAFLD), a vast-growing etiology of primary liver tumors which are major indic...

    Authors: Anastasia Murtha-Lemekhova, Juri Fuchs, Svenja Feiler, Erik Schulz, Miriam Teroerde, Eva Kalkum, Rosa Klotz, Adrian Billeter, Pascal Probst and Katrin Hoffmann
    Citation: BMC Medicine 2022 20:47
  6. Emerging evidence supports an association between vaginal microbiota composition and risk of miscarriage; however, the underlying mechanisms are poorly understood. We aim to investigate the vaginal microbial c...

    Authors: Karen Grewal, Yun S. Lee, Ann Smith, Jan J. Brosens, Tom Bourne, Maya Al-Memar, Samit Kundu, David A. MacIntyre and Phillip R. Bennett
    Citation: BMC Medicine 2022 20:38
  7. Evidence on vaccine-specific protection over time, in particular against the Delta variant, and protection afforded by a homologous third dose is urgently needed.

    Authors: Xinhua Chen, Wei Wang, Xinghui Chen, Qianhui Wu, Ruijia Sun, Shijia Ge, Nan Zheng, Wanying Lu, Juan Yang, Lance Rodewald and Hongjie Yu
    Citation: BMC Medicine 2022 20:36
  8. The development of the human placenta is tightly coordinated by a multitude of placental cell types, including human chorionic villi mesenchymal stromal cells (hCV-MSCs). Defective hCV-MSCs have been reported ...

    Authors: Sophia Indira Romberg, Nina-Naomi Kreis, Alexandra Friemel, Susanne Roth, Alice Steglich Souto, Samira Catharina Hoock, Kyra Fischer, Thorsten Nowak, Christine Solbach, Frank Louwen, Andreas Ritter and Juping Yuan
    Citation: BMC Medicine 2022 20:35
  9. Understanding the age patterns of disease is necessary to target interventions to maximise cost-effective impact. New malaria chemoprevention and vaccine initiatives target young children attending routine imm...

    Authors: Alice Kamau, Robert S. Paton, Samuel Akech, Arthur Mpimbaza, Cynthia Khazenzi, Morris Ogero, Eda Mumo, Victor A. Alegana, Ambrose Agweyu, Neema Mturi, Shebe Mohammed, Godfrey Bigogo, Allan Audi, James Kapisi, Asadu Sserwanga, Jane F. Namuganga…
    Citation: BMC Medicine 2022 20:28
  10. The prevalence of overweight and obesity is increasing among African children potentially predisposing them to greater obesity and non-communicable diseases (NCDs) in adulthood. This risk may be higher among g...

    Authors: Kurt Z. Long, Johanna Beckmann, Christin Lang, Harald Seelig, Siphesihle Nqweniso, Nicole Probst-Hensch, Ivan Müller, Uwe Pühse, Peter Steinmann, Rosa du Randt, Cheryl Walter, Jürg Utzinger and Markus Gerber
    Citation: BMC Medicine 2022 20:27
  11. Clinical trials have demonstrated that initiating oral anti-diabetic drugs (OADs) significantly reduce glycated hemoglobin (HbA1c) levels. However, variability in lifestyle modifications and OAD adherence impa...

    Authors: Hao Sen Andrew Fang, Qiao Gao, Wei Ying Tan, Mong Li Lee, Wynne Hsu and Ngiap Chuan Tan
    Citation: BMC Medicine 2022 20:22
  12. Heart failure with preserved ejection fraction (HFpEF) is the dominant form of heart failure (HF). We here aimed to investigate the characteristics and prognosis of HFpEF in patients with hypertrophic cardiomy...

    Authors: Jie Liu, Dong Wang, Jieyun Ruan, Guixin Wu, Lianjun Xu, Wen Jiang, Jizheng Wang, Xiaolu Sun, Lianming Kang and Lei Song
    Citation: BMC Medicine 2022 20:21
  13. Protection from severe disease and hospitalization by SARS-CoV-2 vaccination has been amply demonstrated by real-world data. However, the rapidly evolving pandemic raises new concerns. One pertains efficacy of...

    Authors: Rahul Ukey, Natalie Bruiners, Hridesh Mishra, Pankaj K. Mishra, Deborah McCloskey, Alberta Onyuka, Fei Chen, Abraham Pinter, Daniela Weiskopf, Alessandro Sette, Jason Roy, Sunanda Gaur and Maria Laura Gennaro
    Citation: BMC Medicine 2022 20:32
  14. Telomere length (TL) and its attrition are important indicators of physiological stress and biological aging and hence may vary among individuals of the same age. This variation is apparent even in newborns, s...

    Authors: Li Chen, Karen Mei Ling Tan, Min Gong, Mary F. F. Chong, Kok Hian Tan, Yap Seng Chong, Michael J. Meaney, Peter D. Gluckman, Johan G. Eriksson and Neerja Karnani
    Citation: BMC Medicine 2022 20:20
  15. Hypertensive disorders of pregnancy are common pregnancy complications that are associated with greater cardiovascular disease risk for mothers. However, risk of cardiovascular disease subtypes associated with...

    Authors: Clare Oliver-Williams, David Stevens, Rupert A. Payne, Ian B. Wilkinson, Gordon C. S. Smith and Angela Wood
    Citation: BMC Medicine 2022 20:19
  16. Alanine aminotransferase (ALT) levels are widely used to screen liver disease, and many asymptomatic individuals show elevated ALT levels. As elevated ALT level indicates liver injury, even a small amount of a...

    Authors: Dong Hyun Sinn, Danbee Kang, Eliseo Guallar, Yun Soo Hong, Juhee Cho and Geum-Youn Gwak
    Citation: BMC Medicine 2022 20:18
  17. The humoral immune response after primary immunisation with a SARS-CoV-2 vector vaccine (AstraZeneca AZD1222, ChAdOx1 nCoV-19, Vaxzevria) followed by an mRNA vaccine boost (Pfizer/BioNTech, BNT162b2; Moderna, ...

    Authors: Ruben Rose, Franziska Neumann, Olaf Grobe, Thomas Lorentz, Helmut Fickenscher and Andi Krumbholz
    Citation: BMC Medicine 2022 20:31
  18. With the recent certification by World Health Organization that the People’s Republic of China is malaria-free, it is timely to consider how elimination of malaria was completed in People’s Republic of China o...

    Authors: Guo-Jing Yang, Le-Yuan Shang, Xiao-Nong Zhou, Tamsin E. Lee, Bo Bi, Michael White, Thomas A. Smith and Melissa A. Penny
    Citation: BMC Medicine 2022 20:17
  19. Surgical resection followed by chemo-radiation postpones glioblastoma (GBM) progression and extends patient survival, but these tumours eventually recur. Multimodal treatment plans combining intraoperative tec...

    Authors: Justyna Mączyńska, Florian Raes, Chiara Da Pieve, Stephen Turnock, Jessica K. R. Boult, Julia Hoebart, Marcin Niedbala, Simon P. Robinson, Kevin J. Harrington, Wojciech Kaspera and Gabriela Kramer-Marek
    Citation: BMC Medicine 2022 20:16

    The Correction to this article has been published in BMC Medicine 2022 20:179

  20. Heart failure (HF) is increasingly prevalent in the growing elderly population and commonly associated with cognitive impairment. We compared trends in place of death (PoD) of HF patients with/without comorbid...

    Authors: James M. Beattie, Irene J. Higginson, Theresa A. McDonagh and Wei Gao
    Citation: BMC Medicine 2022 20:30
  21. COVID-19 is an infectious disease characterized by multiple respiratory and extrapulmonary manifestations, including gastrointestinal symptoms. Although recent studies have linked gut microbiota to infectious ...

    Authors: Zhonghan Sun, Zhi-Gang Song, Chenglin Liu, Shishang Tan, Shuchun Lin, Jiajun Zhu, Fa-Hui Dai, Jian Gao, Jia-Lei She, Zhendong Mei, Tao Lou, Jiao-Jiao Zheng, Yi Liu, Jiang He, Yuanting Zheng, Chen Ding…
    Citation: BMC Medicine 2022 20:24
  22. Sex influences outcome of patients with acute coronary syndrome (ACS). If there is a relationship between sex and physical performance is unknown.

    Authors: Elisabetta Tonet, Albert Ariza-Solé, Matteo Serenelli, Francesc Formiga, Juan Sanchis, Rita Pavasini, Pablo Diez-Villanueva, Francesco Vitali, Clara Bonanad, Giovanni Grazzi, Antoni Carol, Giorgio Chiaranda, Graziella Pompei, Laura Sofia Cardelli, Serena Caglioni, Federico Gibiino…
    Citation: BMC Medicine 2022 20:15
  23. While vaccination programs against the severe acute respiratory syndrome virus 2 (SARS-CoV-2) are globally ongoing, disparate strategies for the deployment of spike antigen show varying effectiveness.

    Authors: Michael Müller, Johann Volzke, Behnam Subin, Silke Müller, Martina Sombetzki, Emil C. Reisinger and Brigitte Müller-Hilke
    Citation: BMC Medicine 2022 20:29
  24. Chronic kidney disease (CKD) is associated with increased propensity for arrhythmias. In this context, ventricular repolarization alterations have been shown to predispose to fatal arrhythmias and sudden cardi...

    Authors: José Alberto Navarro-García, Rafael Salguero-Bodes, Laura González-Lafuente, Laura Martín-Nunes, Elena Rodríguez-Sánchez, Teresa Bada-Bosch, Eduardo Hernández, Evangelina Mérida-Herrero, Manuel Praga, Jorge Solís, Fernando Arribas, Héctor Bueno, Makoto Kuro-O, María Fernández-Velasco, Luis Miguel Ruilope, Carmen Delgado…
    Citation: BMC Medicine 2022 20:14
  25. Recaticimab (SHR-1209, a humanized monoclonal antibody against PCSK9) showed robust LDL-C reduction in healthy volunteers. This study aimed to further assess the efficacy and safety of recaticimab in patients ...

    Authors: Mingtong Xu, Xiaoxue Zhu, Junyan Wu, Yuling Zhang, Dong Zhao, Xuhong Wang, Yanhua Ding, Yu Cao, Chengqian Li, Wei Hu, Jianlong Sheng, Zhu Luo, Zeqi Zheng, Jinfang Hu, Jianying Liu, Xiaoyang Zhou…
    Citation: BMC Medicine 2022 20:13
  26. Central nervous system (CNS) metastases in patients with ALK-positive non-small cell lung cancer (NSCLC) are a cause of substantial morbidity and mortality. Although alectinib had demonstrated promising intrac...

    Authors: Zihua Zou, Puyuan Xing, Xuezhi Hao, Yan Wang, Xia Song, Li Shan, Cuiying Zhang, Ziling Liu, Kewei Ma, Guilan Dong and Junling Li
    Citation: BMC Medicine 2022 20:12
  27. There is considerable variability in disease progression for patients with amyotrophic lateral sclerosis (ALS) including the age of disease onset, site of disease onset, and survival time. There is growing evi...

    Authors: Frances Theunissen, Loren L. Flynn, Ryan S. Anderton and P. Anthony Akkari
    Citation: BMC Medicine 2022 20:11
  28. Nudging is increasingly used to promote healthy food choices in supermarkets. Ordering groceries online is gaining in popularity and nudging seems efficacious there as well, but is never comprehensively tested...

    Authors: Josine M. Stuber, Jeroen Lakerveld, Loes W. Kievitsbosch, Joreintje D. Mackenbach and Joline W. J. Beulens
    Citation: BMC Medicine 2022 20:10
  29. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious respiratory virus which is responsible for the coronavirus disease 2019 (COVID-19) pandemic. It is increasingly clear that re...

    Authors: Feargal J. Ryan, Christopher M. Hope, Makutiro G. Masavuli, Miriam A. Lynn, Zelalem A. Mekonnen, Arthur Eng Lip Yeow, Pablo Garcia-Valtanen, Zahraa Al-Delfi, Jason Gummow, Catherine Ferguson, Stephanie O’Connor, Benjamin A. J. Reddi, Pravin Hissaria, David Shaw, Chuan Kok-Lim, Jonathan M. Gleadle…
    Citation: BMC Medicine 2022 20:26
  30. Mother-to-baby transmission of group B Streptococcus (GBS) is the main cause of early-onset infection. We evaluated whether, in women with clinical risk factors for early neonatal infection, the use of point-of-c...

    Authors: Jane P. Daniels, Emily Dixon, Alicia Gill, Jon Bishop, Mark Wilks, Michael Millar, Jim Gray, Tracy E. Roberts, Jane Plumb, Jonathan J. Deeks, Karla Hemming, Khalid S. Khan and Shakila Thangaratinam
    Citation: BMC Medicine 2022 20:9
  31. Aberrant DNA methylation may offer opportunities in revolutionizing cancer screening and diagnosis. We sought to identify a non-invasive DNA methylation-based screening approach using cell-free DNA (cfDNA) for...

    Authors: Biyuan Luo, Fang Ma, Hao Liu, Jixiong Hu, Le Rao, Chun Liu, Yongfang Jiang, Shuyu Kuangzeng, Xuan Lin, Chenyang Wang, Yiyu Lei, Zhongzhou Si, Guangshun Chen, Ning Zhou, Chengbai Liang, Fangqing Jiang…
    Citation: BMC Medicine 2022 20:8
  32. Relationships between viral load, severity of illness, and transmissibility of virus are fundamental to understanding pathogenesis and devising better therapeutic and prevention strategies for COVID-19. Here w...

    Authors: Joseph D. Challenger, Cher Y. Foo, Yue Wu, Ada W. C. Yan, Mahdi Moradi Marjaneh, Felicity Liew, Ryan S. Thwaites, Lucy C. Okell and Aubrey J. Cunnington
    Citation: BMC Medicine 2022 20:25
  33. The overall consumption of ultra-processed food (UPF) has previously been associated with type 2 diabetes. However, due to the substantial heterogeneity of this food category, in terms of their nutritional com...

    Authors: Ming-Jie Duan, Petra C. Vinke, Gerjan Navis, Eva Corpeleijn and Louise H. Dekker
    Citation: BMC Medicine 2022 20:7
  34. The relation of the variety and quantity of different sources of dietary proteins intake and diabetes remains uncertain. We aimed to investigate the associations between the variety and quantity of proteins in...

    Authors: Chun Zhou, Chengzhang Liu, Zhuxian Zhang, Mengyi Liu, Yuanyuan Zhang, Huan Li, Panpan He, Qinqin Li and Xianhui Qin
    Citation: BMC Medicine 2022 20:6
  35. Health economic evaluations are comparative analyses of alternative courses of action in terms of their costs and consequences. The Consolidated Health Economic Evaluation Reporting Standards (CH...

    Authors: Don Husereau, Michael Drummond, Federico Augustovski, Esther de Bekker-Grob, Andrew H. Briggs, Chris Carswell, Lisa Caulley, Nathorn Chaiyakunapruk, Dan Greenberg, Elizabeth Loder, Josephine Mauskopf, C. Daniel Mullins, Stavros Petrou, Raoh-Fang Pwu and Sophie Staniszewska
    Citation: BMC Medicine 2022 20:23
  36. Genetic and lifestyle factors have considerable effects on obesity and related diseases, yet their effects in a clinical cohort are unknown. This study in a patient biobank examined associations of a BMI polyg...

    Authors: Hassan S. Dashti, Nicole Miranda, Brian E. Cade, Tianyi Huang, Susan Redline, Elizabeth W. Karlson and Richa Saxena
    Citation: BMC Medicine 2022 20:5
  37. The associations of maternal cigarette smoking with congenital anomalies in offspring have been inconsistent. This study aimed to clarify the associations of the timing and intensity of maternal cigarette smok...

    Authors: Lili Yang, Huan Wang, Liu Yang, Min Zhao, Yajun Guo, Pascal Bovet and Bo Xi
    Citation: BMC Medicine 2022 20:4
  38. Epidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due to bias. In order to exa...

    Authors: Emmanouil Bouras, Ville Karhunen, Dipender Gill, Jian Huang, Philip C. Haycock, Marc J. Gunter, Mattias Johansson, Paul Brennan, Tim Key, Sarah J. Lewis, Richard M. Martin, Neil Murphy, Elizabeth A. Platz, Ruth Travis, James Yarmolinsky, Verena Zuber…
    Citation: BMC Medicine 2022 20:3
  39. Clinical practice guidelines recommend sodium-glucose co-transporter 2 inhibitors (SGLT2is) to mitigate adverse kidney and cardiovascular outcomes in patients with type 2 diabetes (T2D), including patients wit...

    Authors: Csaba Kovesdy, Niklas Schmedt, Kerstin Folkerts, Kevin Bowrin, Hanaya Raad, Michael Batech and Linda Fried
    Citation: BMC Medicine 2022 20:2
  40. Previous studies have shown an association between experience of intimate partner violence and abuse (IPVA) and depression. Whether this is a causal relationship or explained by prior vulnerability that influe...

    Authors: Annie Herbert, Jon Heron, Maria Barnes, Christine Barter, Gene Feder, Khadija Meghrawi, Eszter Szilassy, Abigail Fraser and Laura D. Howe
    Citation: BMC Medicine 2022 20:1
  41. To investigate the prevalence of robust conclusions in systematic reviews addressing missing (participant) outcome data via a novel framework of sensitivity analyses and examine the agreement with the current ...

    Authors: Loukia M. Spineli, Chrysostomos Kalyvas and Katerina Papadimitropoulou
    Citation: BMC Medicine 2021 19:323
  42. It is not a rare clinical scenario to have patients presenting with coexisting malignant tumor and tuberculosis. Whether it is feasible to conduct programmed death-(ligand) 1 [PD-(L)1] inhibitors to these pati...

    Authors: Shan Su, Mei-Feng Ye, Xiao-Ting Cai, Xue Bai, Zhi-Hao Huang, Si-Cong Ma, Jian-Jun Zou, Yu-Xiang Wen, Li-Juan Wu, Xue-Jun Guo, Xian-Lan Zhang, Wen-Chang Cen, Duo-Hua Su, Hui-Yi Huang and Zhong-Yi Dong
    Citation: BMC Medicine 2021 19:322
  43. Transcranial direct current stimulation (tDCS) has shown mixed results for depression treatment. The efficacies of tDCS combination therapies have not been investigated deliberately. This review aims to evalua...

    Authors: Jingying Wang, Huichun Luo, Rasmus Schülke, Xinyi Geng, Barbara J. Sahakian and Shouyan Wang
    Citation: BMC Medicine 2021 19:319
  44. Polypharmacy is common among older people and is associated with an increased mortality risk. However, little is known about whether the mortality risk is related to specific medications among older adults wit...

    Authors: Yun-Ting Huang, Andrew Steptoe, Li Wei and Paola Zaninotto
    Citation: BMC Medicine 2021 19:321
  45. Obesity is a worldwide epidemic that has been associated with a plurality of diseases in observational studies. The aim of this study was to summarize the evidence from Mendelian randomization (MR) studies of ...

    Authors: Susanna C. Larsson and Stephen Burgess
    Citation: BMC Medicine 2021 19:320
  46. Short-course, rifamycin-based regimens could facilitate scale-up of tuberculosis preventive therapy (TPT), but it is unclear how stringently tuberculosis (TB) disease should be ruled out before TPT use.

    Authors: Emily A. Kendall, Hamidah Hussain, Amber Kunkel, Rachel W. Kubiak, Anete Trajman, Richard Menzies and Paul K. Drain
    Citation: BMC Medicine 2021 19:315
  47. Recent genome-wide association studies (GWASs) have revealed the polygenic nature of psychiatric disorders and discovered a few of single-nucleotide polymorphisms (SNPs) associated with multiple psychiatric di...

    Authors: Haojie Lu, Jiahao Qiao, Zhonghe Shao, Ting Wang, Shuiping Huang and Ping Zeng
    Citation: BMC Medicine 2021 19:314
  48. Metabolomics is a promising molecular tool for identifying novel etiological pathways leading to cancer. In an earlier prospective study among pre- and postmenopausal women not using exogenous hormones, we obs...

    Authors: Mathilde His, Vivian Viallon, Laure Dossus, Julie A. Schmidt, Ruth C. Travis, Marc J. Gunter, Kim Overvad, Cecilie Kyrø, Anne Tjønneland, Lucie Lécuyer, Joseph A. Rothwell, Gianluca Severi, Theron Johnson, Verena Katzke, Matthias B. Schulze, Giovanna Masala…
    Citation: BMC Medicine 2021 19:312
  49. During starvation, fasting, or a diet containing little digestible carbohydrates, the circulating insulin levels are decreased. This promotes lipolysis, and the breakdown of fat becomes the major source of ene...

    Authors: Hubert Kolb, Kerstin Kempf, Martin Röhling, Martina Lenzen-Schulte, Nanette C. Schloot and Stephan Martin
    Citation: BMC Medicine 2021 19:313