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  1. Content type: Research article

    Studies have shown that alcohol intake trajectories differ in their associations with biomarkers of cardiovascular functioning, but it remains unclear if they also differ in their relationship to actual corona...

    Authors: Dara O’Neill, Annie Britton, Mary K. Hannah, Marcel Goldberg, Diana Kuh, Kay Tee Khaw and Steven Bell

    Citation: BMC Medicine 2018 16:124

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  2. Content type: Research article

    The prognosis of pancreatic cancer (PaC) strongly varies across different stages and age groups, which has unfortunately not been well recorded in the literature. This international population-based study aime...

    Authors: Lei Huang, Lina Jansen, Yesilda Balavarca, Masoud Babaei, Lydia van der Geest, Valery Lemmens, Liesbet Van Eycken, Harlinde De Schutter, Tom B. Johannesen, Maja Primic-Žakelj, Vesna Zadnik, Marc G. Besselink, Petra Schrotz-King and Hermann Brenner

    Citation: BMC Medicine 2018 16:125

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  3. Content type: Research article

    Although routine vaccination of females before sexual debut against human papillomavirus (HPV) has been found to be cost-effective around the world, its cost-benefit has rarely been examined. We evaluate both ...

    Authors: Horace C. W. Choi, Mark Jit, Gabriel M. Leung, Kwok-Leung Tsui and Joseph T. Wu

    Citation: BMC Medicine 2018 16:127

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  4. Content type: Research article

    Enterobacteriaceae are a common cause of hospital infections. Carbapenems are a clinically effective treatment of such infections. However, resistance is on the rise. In particular, carbapenemase-producing car...

    Authors: Gwenan M. Knight, Eleonora Dyakova, Siddharth Mookerjee, Frances Davies, Eimear T. Brannigan, Jonathan A. Otter and Alison H. Holmes

    Citation: BMC Medicine 2018 16:141

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  5. Content type: Opinion

    In an era when obesity prevalence is high throughout much of the world, there is a correspondingly pervasive and strong culture of weight stigma. For example, representative studies show that some forms of wei...

    Authors: A. Janet Tomiyama, Deborah Carr, Ellen M. Granberg, Brenda Major, Eric Robinson, Angelina R. Sutin and Alexandra Brewis

    Citation: BMC Medicine 2018 16:123

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  6. Content type: Research article

    Whilst observational studies establish that lower plasma 25-hydroxyvitamin D (25-OHD) levels are associated with higher risk of colorectal cancer (CRC), establishing causality has proven challenging. Since vit...

    Authors: Yazhou He, Maria Timofeeva, Susan M. Farrington, Peter Vaughan-Shaw, Victoria Svinti, Marion Walker, Lina Zgaga, Xiangrui Meng, Xue Li, Athina Spiliopoulou, Xia Jiang, Elina Hyppönen, Peter Kraft, Douglas P. Kiel, Caroline Hayward, Archie Campbell…

    Citation: BMC Medicine 2018 16:142

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  7. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease worldwide. It affects an estimated 20% of the general population, based on cohort studies of varying size and heterogeneous s...

    Authors: Myriam Alexander, A. Katrina Loomis, Jolyon Fairburn-Beech, Johan van der Lei, Talita Duarte-Salles, Daniel Prieto-Alhambra, David Ansell, Alessandro Pasqua, Francesco Lapi, Peter Rijnbeek, Mees Mosseveld, Paul Avillach, Peter Egger, Stuart Kendrick, Dawn M. Waterworth, Naveed Sattar…

    Citation: BMC Medicine 2018 16:130

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    The Commentary to this article has been published in BMC Medicine 2018 16:148

  8. Content type: Retraction Note

    The authors have retracted this article, The impact of repeated vaccination on influenza vaccine effectiveness: a systematic review and meta-analysis.

    Authors: Lauren C. Ramsay, Sarah A. Buchan, Robert G. Stirling, Benjamin J. Cowling, Shou Feng, Jeffrey C. Kwong and Bryna F. Warshawsky

    Citation: BMC Medicine 2018 16:133

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    The original article was published in BMC Medicine 2017 15:159

  9. Content type: Correction

    The original article [1] contains an error affecting the actigraphy time-stamps throughout the article, particularly in Table 1.

    Authors: D. Cruse, A. Thibaut, A. Demertzi, J. C. Nantes, M. A. Bruno, O. Gosseries, A. Vanhaudenhuyse, T. A. Bekinschtein, A. M. Owen and S. Laureys

    Citation: BMC Medicine 2018 16:134

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    The original article was published in BMC Medicine 2013 11:18

  10. Content type: Research article

    A recent concept is that obesity, assessed by body mass index (BMI), is not always a sign of poor health. Thus, in order to use obesity metrics in clinical decision making, it is important to clarify the relat...

    Authors: Geum Joon Cho, Hye Jin Yoo, Soon Young Hwang, Jun Choi, Kyu-Min Lee, Kyung Mook Choi, Sei Hyun Baik, Sung Won Han and Tak Kim

    Citation: BMC Medicine 2018 16:131

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  11. Content type: Research article

    Online dietary assessment tools can reduce administrative costs and facilitate repeated dietary assessment during follow-up in large-scale studies. However, information on bias due to measurement error of such...

    Authors: Petra A. Wark, Laura J. Hardie, Gary S. Frost, Nisreen A. Alwan, Michelle Carter, Paul Elliott, Heather E. Ford, Neil Hancock, Michelle A. Morris, Umme Z. Mulla, Essra A. Noorwali, K. Petropoulou, David Murphy, Gregory D. M. Potter, Elio Riboli, Darren C. Greenwood…

    Citation: BMC Medicine 2018 16:136

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  12. Content type: Research article

    In Canada, tuberculosis disproportionately affects foreign-born and First Nations populations. Within First Nations’ peoples, a high proportion of cases occur in association with outbreaks. Tuberculosis transm...

    Authors: Alexander Doroshenko, Caitlin S. Pepperell, Courtney Heffernan, Mary Lou Egedahl, Tatum D. Mortimer, Tracy M. Smith, Hailey E. Bussan, Gregory J. Tyrrell and Richard Long

    Citation: BMC Medicine 2018 16:128

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  13. Content type: Research article

    Antibiotic resistance is an urgent global problem, but reversibility is poorly understood. We examined the development and decay of bacterial resistance in community patients after antibiotic use.

    Authors: Mina Bakhit, Tammy Hoffmann, Anna Mae Scott, Elaine Beller, John Rathbone and Chris Del Mar

    Citation: BMC Medicine 2018 16:126

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  14. Content type: Research article

    Dengue, a vector-borne infectious disease caused by the dengue virus, has spread through tropical and subtropical regions of the world. All four serotypes of dengue viruses are endemic in the equatorial city s...

    Authors: Yirong Chen, Janet Hui Yi Ong, Jayanthi Rajarethinam, Grace Yap, Lee Ching Ng and Alex R. Cook

    Citation: BMC Medicine 2018 16:129

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  15. Content type: Research article

    Congregate settings may serve as institutional amplifiers of tuberculosis (TB) and multidrug-resistant tuberculosis (MDR-TB). We analyze spatial, epidemiological, and pathogen genetic data prospectively collec...

    Authors: Joshua L. Warren, Louis Grandjean, David A. J. Moore, Anna Lithgow, Jorge Coronel, Patricia Sheen, Jonathan L. Zelner, Jason R. Andrews and Ted Cohen

    Citation: BMC Medicine 2018 16:122

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  16. Content type: Research article

    Coeliac disease affects approximately 1% of the population and is increasingly diagnosed in the United Kingdom. A nationwide consultation in England has recommend that state-funded provisions for gluten-free (...

    Authors: Myles-Jay Linton, Tim Jones, Amanda Owen-Smith, Rupert A. Payne, Joanna Coast, Joel Glynn and William Hollingworth

    Citation: BMC Medicine 2018 16:119

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  17. Content type: Opinion

    The results of liver transplantation are excellent, with survival rates of over 90 and 80% at 1 and 5 years, respectively. The success of liver transplantation has led to an increase in the indications for liv...

    Authors: Didier Samuel and Audrey Coilly

    Citation: BMC Medicine 2018 16:113

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  18. Content type: Research article

    Rates of emergency hospitalisations are increasing in many countries, leading to disruption in the quality of care and increases in cost. Therefore, identifying strategies to reduce emergency admission rates i...

    Authors: Niklas Bobrovitz, Carl Heneghan, Igho Onakpoya, Benjamin Fletcher, Dylan Collins, Alice Tompson, Joseph Lee, David Nunan, Rebecca Fisher, Brittney Scott, Jack O’Sullivan, Oliver Van Hecke, Brian D. Nicholson, Sarah Stevens, Nia Roberts and Kamal R. Mahtani

    Citation: BMC Medicine 2018 16:115

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    The Commentary to this article has been published in BMC Medicine 2018 16:169

  19. Content type: Research article

    Sub-Saharan Africa (SSA) continues to suffer high communicable disease burdens as its demographic transition (DT) proceeds. Although the consequent changes in population structures influence age-specific conta...

    Authors: John R. Williams, Piero Manfredi and Alessia Melegaro

    Citation: BMC Medicine 2018 16:118

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  20. Content type: Research article

    The presence of concomitant medical conditions in people with dementia is common. Dementia may be related to differential use of health, social and informal care.

    Authors: Holly Q. Bennett, Sam Norton, Frances Bunn, Louise Robinson, Greta Rait, Claire Goodman, Carol Brayne and Fiona E. Matthews

    Citation: BMC Medicine 2018 16:114

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  21. Content type: Research article

    Most evidence about what works in transitional care comes from small studies in single clinical specialties. We tested the hypothesis that exposures to nine recommended features of transitional healthcare were...

    Authors: A. Colver, H. McConachie, A. Le Couteur, G. Dovey-Pearce, K. D. Mann, J. E. McDonagh, M. S. Pearce, L. Vale, H. Merrick and J. R. Parr

    Citation: BMC Medicine 2018 16:111

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  22. Content type: Research article

    Depression is a prevalent and disabling mental disorder that frequently co-occurs with a wide range of chronic conditions. Evidence has suggested that depression could be associated with excess all-cause morta...

    Authors: Myrela O. Machado, Nicola Veronese, Marcos Sanches, Brendon Stubbs, Ai Koyanagi, Trevor Thompson, Ioanna Tzoulaki, Marco Solmi, Davy Vancampfort, Felipe B. Schuch, Michael Maes, Giovanni A. Fava, John P. A. Ioannidis and André F. Carvalho

    Citation: BMC Medicine 2018 16:112

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    The Commentary to this article has been published in BMC Medicine 2018 16:147

  23. Content type: Research article

    As complete reporting is essential to judge the validity and applicability of multivariable prediction models, a guideline for the Transparent Reporting of a multivariable prediction model for Individual Progn...

    Authors: Pauline Heus, Johanna A. A. G. Damen, Romin Pajouheshnia, Rob J. P. M. Scholten, Johannes B. Reitsma, Gary S. Collins, Douglas G. Altman, Karel G. M. Moons and Lotty Hooft

    Citation: BMC Medicine 2018 16:120

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  24. Content type: Research article

    Human papillomavirus (HPV) vaccination is safe and effective in preventing cervical cancer in females. As HPV infections can also induce cancers of the anus, penis and oral cavity, male vaccination is also adv...

    Authors: Thomas Harder, Ole Wichmann, Stefanie J. Klug, Marianne A. B. van der Sande and Miriam Wiese-Posselt

    Citation: BMC Medicine 2018 16:110

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  25. Content type: Research article

    The present study aims to evaluate the cost-effectiveness of the newly introduced varicella and herpes zoster (HZ) vaccination programmes in Italy. The appropriateness of the introduction of the varicella vacc...

    Authors: Alessia Melegaro, Valentina Marziano, Emanuele Del Fava, Piero Poletti, Marcello Tirani, Caterina Rizzo and Stefano Merler

    Citation: BMC Medicine 2018 16:117

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  26. Content type: Research article

    Intensification of metformin monotherapy with additional glucose-lowering drugs is often required in patients with type 2 diabetes (T2D). This study evaluated changes in HbA1c and weight, as well as treatment ...

    Authors: John Wilding, Thomas Godec, Kamlesh Khunti, Stuart Pocock, Robin Fox, Liam Smeeth, Per Clauson, Peter Fenici, Niklas Hammar and Jesús Medina

    Citation: BMC Medicine 2018 16:116

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  27. Content type: Research article

    The RTS,S/AS01 vaccine for Plasmodium falciparum malaria demonstrated moderate efficacy in 5–17-month-old children in phase 3 trials, and from 2018, the vaccine will be evaluated through a large-scale pilot imple...

    Authors: Alexandra B. Hogan, Peter Winskill, Robert Verity, Jamie T. Griffin and Azra C. Ghani

    Citation: BMC Medicine 2018 16:109

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  28. Content type: Research article

    Caregivers may promote the uptake of science into patient care and the practice of evidence-informed medicine. The purpose of this study was to determine whether caregiver-mediated (non-clinical caregiver-deli...

    Authors: Kirsten M. Fiest, Christiane Job McIntosh, Danielle Demiantschuk, Jeanna Parsons Leigh and Henry T. Stelfox

    Citation: BMC Medicine 2018 16:105

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  29. Content type: Research article

    For patients starting treatment for depression, current guidelines recommend titrating the antidepressant dosage to the maximum of the licenced range if tolerated. When patients do not achieve remission within...

    Authors: Tadashi Kato, Toshi A. Furukawa, Akio Mantani, Ken’ichi Kurata, Hajime Kubouchi, Susumu Hirota, Hirotoshi Sato, Kazuyuki Sugishita, Bun Chino, Kahori Itoh, Yoshio Ikeda, Yoshihiro Shinagawa, Masaki Kondo, Yasumasa Okamoto, Hirokazu Fujita, Motomu Suga…

    Citation: BMC Medicine 2018 16:103

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  30. Content type: Research article

    Genotype-guided warfarin dosing has been shown in some randomized trials to improve anticoagulation outcomes in individuals of European ancestry, yet its utility in Asian patients remains unresolved.

    Authors: Nicholas L. Syn, Andrea Li-Ann Wong, Soo-Chin Lee, Hock-Luen Teoh, James Wei Luen Yip, Raymond CS Seet, Wee Tiong Yeo, William Kristanto, Ping-Chong Bee, LM Poon, Patrick Marban, Tuck Seng Wu, Michael D. Winther, Liam R. Brunham, Richie Soong, Bee-Choo Tai…

    Citation: BMC Medicine 2018 16:104

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  31. Content type: Research article

    The effects of community health worker (CHW) home visiting during the antenatal and postnatal periods in fragile- and conflicted-affected countries such as Afghanistan are not known.

    Authors: Karen M. Edmond, Khaksar Yousufi, Zelaikha Anwari, Sayed Masoud Sadat, Shah Mansoor Staniczai, Ariel Higgins-Steele, Alexandra L. Bellows and Emily R. Smith

    Citation: BMC Medicine 2018 16:106

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  32. Content type: Research article

    The Choosing Wisely campaign highlights the importance of clinical reasoning abilities for competent and reflective physicians. The principles of this campaign should be addressed in undergraduate medical educati...

    Authors: Sascha Ludwig, Nikolai Schuelper, Jamie Brown, Sven Anders and Tobias Raupach

    Citation: BMC Medicine 2018 16:107

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  33. Content type: Research article

    Stratification of cancer patients to identify those with worse prognosis is increasingly important. Through in silico analyses, we recently developed a gene expression-based prognostic score (S3-score) for cle...

    Authors: Florian Büttner, Stefan Winter, Steffen Rausch, Jörg Hennenlotter, Stephan Kruck, Arnulf Stenzl, Marcus Scharpf, Falko Fend, Abbas Agaimy, Arndt Hartmann, Jens Bedke, Matthias Schwab and Elke Schaeffeler

    Citation: BMC Medicine 2018 16:108

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  34. Content type: Research article

    Equitable access to vaccines has been suggested as a priority for low- and middle-income countries (LMICs). However, it is unclear whether providing equitable access is enough to ensure health equity. Furtherm...

    Authors: Angela Y. Chang, Carlos Riumallo-Herl, Joshua A. Salomon, Stephen C. Resch, Logan Brenzel and Stéphane Verguet

    Citation: BMC Medicine 2018 16:102

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  35. Content type: Research article

    Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a worldwide prevalence of 1–2%. In low-resource environments, in particular, early identification and diagnosis is a significant challenge. ...

    Authors: T. Heunis, C. Aldrich, J. M. Peters, S. S. Jeste, M. Sahin, C. Scheffer and P. J. de Vries

    Citation: BMC Medicine 2018 16:101

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  36. Content type: Research article

    The Mediterranean Diet (MedDiet) has been acknowledged as a healthy diet. However, its relation with risk of major chronic diseases in non-Mediterranean countries is inconclusive. The Nordic diet is proposed a...

    Authors: Cecilia Galbete, Janine Kröger, Franziska Jannasch, Khalid Iqbal, Lukas Schwingshackl, Carolina Schwedhelm, Cornelia Weikert, Heiner Boeing and Matthias B. Schulze

    Citation: BMC Medicine 2018 16:99

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  37. Content type: Correspondence

    Malaria at international borders presents particular challenges with regards to elimination. International borders share common malaria ecologies, yet neighboring countries are often at different stages of the...

    Authors: Mohammed H. Al Zahrani, Abdiasiis I. Omar, Abdelmohsin M. O. Abdoon, Ali Adam Ibrahim, Abdullah Alhogail, Mohamed Elmubarak, Yousif Eldirdiry Elamin, Mohammed A. AlHelal, Ali M. Alshahrani, Tarig M. Abdelgader, Ibrahim Saeed, Tageddin B. El Gamri, Mohammed S. Alattas, Abdu A. Dahlan, Abdullah M. Assiri, Joseph Maina…

    Citation: BMC Medicine 2018 16:98

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  38. Content type: Research article

    Globally, illness and life expectancy follow a social gradient that puts people of lower socioeconomic status (SES) at higher risk of dying prematurely. Alcohol consumption has been shown to be a factor contri...

    Authors: Charlotte Probst, Charles D. H. Parry, Hans-Ulrich Wittchen and Jürgen Rehm

    Citation: BMC Medicine 2018 16:97

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  39. Content type: Opinion

    The healthcare system has proved a challenging environment for innovation, especially in the area of health services management and research. This is often attributed to the complexity of the healthcare sector...

    Authors: Katrina M. Long, Fiona McDermott and Graham N. Meadows

    Citation: BMC Medicine 2018 16:94

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  40. Content type: Research article

    Despite limited information on neonatal safety, the transfer of frozen-thawed cleavage-stage embryos with blastomere loss is common in women undergoing in vitro fertilization. We aimed to evaluate the pregnanc...

    Authors: Yan-Ting Wu, Cheng Li, Yi-Min Zhu, Shu-Hua Zou, Qiong-Fang Wu, Li-Ping Wang, Yan Wu, Rong Yin, Chao-Yi Shi, Jing Lin, Zi-Ru Jiang, Yi-Jing Xu, Yun-Fei Su, Jian Zhang, Jian-Zhong Sheng, William D. Fraser…

    Citation: BMC Medicine 2018 16:96

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  41. Content type: Research article

    Existing evidence remains inconclusive as to the association between chronic hepatitis B virus (HBV) infection and the risk of chronic kidney disease (CKD). We prospectively examined the association between ch...

    Authors: Jiahui Si, Canqing Yu, Yu Guo, Zheng Bian, Chenxi Qin, Ling Yang, Yiping Chen, Li Yin, Hui Li, Jian Lan, Junshi Chen, Zhengming Chen, Jun Lv and Liming Li

    Citation: BMC Medicine 2018 16:93

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  42. Content type: Debate

    More than 65 million persons are currently forcibly displaced, of whom more than 22 million are refugees. Conflicts are increasing, and existing ones are becoming more protracted; a refugee remains a refugee f...

    Authors: Paul Spiegel, Rebecca Chanis and Antonio Trujillo

    Citation: BMC Medicine 2018 16:90

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  43. Content type: Research article

    Media depictions and laws passed in state legislatures regulating abortion suggest abortion-related medical emergencies are common. An accurate understanding of abortion-related emergencies is important for in...

    Authors: Ushma D. Upadhyay, Nicole E. Johns, Rebecca Barron, Alice F. Cartwright, Chantal Tapé, Alyssa Mierjeski and Alyson J. McGregor

    Citation: BMC Medicine 2018 16:88

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  44. Content type: Research article

    Polypharmacy is an increasing challenge for primary care. Although sometimes clinically justified, polypharmacy can be inappropriate, leading to undesirable outcomes. Optimising care for polypharmacy necessita...

    Authors: Jenni Burt, Natasha Elmore, Stephen M. Campbell, Sarah Rodgers, Anthony J. Avery and Rupert A. Payne

    Citation: BMC Medicine 2018 16:91

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