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  1. Accurate prediction of bacteremia is essential for guiding blood culture collection and optimal antibiotic treatment. Shaking chills, defined as a subjective chill sensation with objective body shivering, have...

    Authors: Tetsuro Aita, Hiroaki Nakagawa, Sei Takahashi, Toru Naganuma, Keisuke Anan, Masahiro Banno and Sugihiro Hamaguchi
    Citation: BMC Medicine 2024 22:240
    Content type: Research article Published on:

  2. Mitochondrial (MT) dysfunction is a hallmark of liver diseases. However, the effects of functional variants such as protein truncating variants (PTVs) in MT-related genes on the risk of liver diseases have not...

    Authors: Huangbo Yuan, Zhenqiu Liu, Mingyang Chen, Qiaoyi Xu, Yanfeng Jiang, Tiejun Zhang, Chen Suo and Xingdong Chen
    Citation: BMC Medicine 2024 22:239
    Content type: Research article Published on:

  3. Cerebral palsy (CP), the most common physical disability of childhood, is often accompanied by a range of comorbidities including pain. Pain is highly prevalent in children and young people with CP, yet has be...

    Authors: Adrienne Harvey, Nadine Smith, Meredith Smith, Katarina Ostojic and Carolyn Berryman
    Citation: BMC Medicine 2024 22:238
    Content type: Review Published on:

  4. Immunocompromised individuals are at increased risk of severe COVID-19 outcomes, underscoring the importance of COVID-19 vaccination in this population. The lack of comprehensive real-world data on vaccine upt...

    Authors: Daniel Tzu-Hsuan Chen, Emma Copland, Jennifer A. Hirst, Emma Mi, Sharon Dixon, Carol Coupland and Julia Hippisley-Cox
    Citation: BMC Medicine 2024 22:237
    Content type: Research article Published on:

  5. As global aging accelerates, routinely assessing the functional status and morbidity burden of older patients becomes paramount. The aim of this study is to assess the validity of the comprehensive clinical an...

    Authors: Ahmad Abbadi, Emmanouil Kokoroskos, Matthew Stamets, Davide L. Vetrano, Nicola Orsini, Sölve Elmståhl, Cecilia Fagerström, Anders Wimo, Anders Sköldunger, Johan Sanmartin Berglund, Christina B. Olsson, Caroline Wachtler, Laura Fratiglioni and Amaia Calderón-Larrañaga
    Citation: BMC Medicine 2024 22:236
    Content type: Research article Published on:

  6. Although missed appointments in healthcare have been an area of concern for policy, practice and research, the primary focus has been on reducing single ‘situational’ missed appointments to the benefit of serv...

    Authors: Calum Lindsay, David Baruffati, Mhairi Mackenzie, David A. Ellis, Michelle Major, Catherine A. O’Donnell, Sharon A. Simpson, Andrea E. Williamson and Geoff Wong
    Citation: BMC Medicine 2024 22:235
    Content type: Research Published on:

  7. The standard care for resectable non-small cell lung cancer (NSCLC) involves perioperative therapy combining chemotherapy and immune checkpoint inhibitors, typically lasting 6 to 12 months. However, the optima...

    Authors: Jianzhen Shan, Zhen Liu, Songan Chen, Chengli Du, Bing Li, Lingxiang Ruan, Mei Kong, Lingjie Wang, Miaoyan Du, Shuo Shi, Guoliang Qiao, Tian Tian and Zhengliang Tu
    Citation: BMC Medicine 2024 22:234
    Content type: Research article Published on:

  8. Among patients diagnosed with schizophrenia, the presence of substance use poses an aggravating comorbidity, exerting a negative impact on the course of the disease, adherence to therapeutic regimens, treatmen...

    Authors: Achim Burrer, Stephan T. Egger, Tobias R. Spiller, Matthias Kirschner, Philipp Homan, Erich Seifritz and Stefan Vetter
    Citation: BMC Medicine 2024 22:233
    Content type: Research article Published on:

  9. Geriatric assessment and management (GAM) improve outcomes in older patients with cancer treated with surgery or chemotherapy. It is unclear whether GAM may provide better function and quality of life (QoL), o...

    Authors: Marit Slaaen, Inga Marie Røyset, Ingvild Saltvedt, Bjørn Henning Grønberg, Vidar Halsteinli, Øystein Døhl, Corinna Vossius, Øyvind Kirkevold, Sverre Bergh, Siri Rostoft, Line Oldervoll, Asta Bye, Line Melby, Tove Røsstad, Guro Falk Eriksen, May Ingvild Volungholen Sollid…
    Citation: BMC Medicine 2024 22:232
    Content type: Research article Published on:

  10. Global progress on malaria control has stalled recently, partly due to challenges in universal access to malaria diagnosis and treatment. Community health workers (CHWs) can play a key role in improving access...

    Authors: Andres Garchitorena, Aina Harimanana, Judickaelle Irinantenaina, Hobisoa Léa Razanadranaivo, Tsinjo Fehizoro Rasoanaivo, Dean Sayre, Julie R. Gutman, Reziky Tiandraza Mangahasimbola, Masiarivony Ravaoarimanga, Oméga Raobela, Lala Yvette Razafimaharo, Nicolas Ralemary, Mahefa Andrianasolomanana, Julie Pontarollo, Aline Mukerabirori, Walter Ochieng…
    Citation: BMC Medicine 2024 22:231
    Content type: Research article Published on:

  11. Obesity and central obesity are multifactorial conditions with genetic and non-genetic (lifestyle and environmental) contributions. There is incomplete understanding of whether lifestyle modifies the translati...

    Authors: Mengrong Zhang, Joey Ward, Rona J. Strawbridge, Carlos Celis-Morales, Jill P. Pell, Donald M. Lyall and Frederick K. Ho
    Citation: BMC Medicine 2024 22:230
    Content type: Research article Published on:

  12. Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive ages. Our previous study has implicated a possible link between RNA editing and PCOS, yet the actual role of R...

    Authors: Fan-Sheng Kong, Junjie Feng, Jin-Ping Yao, Yinghua Lu, Tao Guo, Meng Sun, Chun-Yan Ren, Yun-Yun Jin, Yaping Ma and Jian-Huan Chen
    Citation: BMC Medicine 2024 22:229
    Content type: Research article Published on:

  13. Supermarket interventions are promising to promote healthier dietary patterns, but not all individuals may be equally susceptible. We explored whether the effectiveness of nudging and pricing strategies on die...

    Authors: Josine M. Stuber, Joline W. J. Beulens, Juul J. E. van Lierop, Esmee Schuurman, Jeroen Lakerveld and Joreintje D. Mackenbach
    Citation: BMC Medicine 2024 22:228
    Content type: Research Published on:

  14. We quantified SARS-CoV-2 dynamics in different community settings and the direct and indirect effect of the BNT162b2 mRNA vaccine in Monaco for different variants of concern (VOC).

    Authors: Thomas Althaus, Christopher E. Overton, Isabelle Devaux, Thomas House, Arnaud Lapouze, Alexa Troel, Bertrand Vanzo, Margaux Laroche, Alexandre Bordero, Pernille Jorgensen, Richard Pebody and Eric J. Voiglio
    Citation: BMC Medicine 2024 22:227
    Content type: Research article Published on:

  15. Previous studies have linked adolescent motherhood to adverse neurodevelopmental outcomes in offspring, yet the sex-specific effect and underlying mechanisms remain unclear.

    Authors: Tai Ren, Lingli Zhang, Yongjie Liu, Qingli Zhang, Yunjun Sun, Wei Zhou, Like Huang, Ming Wang, Yiwei Pu, Runqi Huang, Jingyu Chen, Hua He, Tailin Zhu, Susu Wang, Weiran Chen, Qianlong Zhang…
    Citation: BMC Medicine 2024 22:226
    Content type: Research article Published on:

  16. Depression and sleep disturbances are associated with increased risks of various diseases and mortality, but their impacts on mortality in cancer survivors remain unclear. The objective of this study was to ch...

    Authors: Ailin Lan, Han Li, Meiying Shen, Daxue Li, Dan Shu, Yang Liu, Haozheng Tang, Kang Li, Yang Peng and Shengchun Liu
    Citation: BMC Medicine 2024 22:225
    Content type: Research article Published on:

  17. Type 2 diabetes is associated with a variety of complications, including micro- and macrovascular complications, neurological manifestations and poor wound healing. Adhering to a Mediterranean Diet (MED) is ge...

    Authors: Changbo Qu, Jinyu Zhao, Jicai Lai, Xinxiang Wu, Peng Huang, Ting Zhu, Yan Li, Taoli Liu, Jinqiu Yuan, Ning Wang, Maikel P Peppelenbosch, Hongda Chen, Bin Xia and Jian Qin
    Citation: BMC Medicine 2024 22:224
    Content type: Research article Published on:

  18. The trajectory of attention-deficit hyperactivity disorder (ADHD) symptoms in children and adolescents, encompassing descending, stable, and ascending patterns, delineates their ADHD status as remission, persi...

    Authors: Yanpei Wang, Leilei Ma, Jiali Wang, Yuyin Ding, Ningyu Liu, Weiwei Men, Shuping Tan, Jia-Hong Gao, Shaozheng Qin, Yong He, Qi Dong and Sha Tao
    Citation: BMC Medicine 2024 22:223
    Content type: Research article Published on:

  19. It is a requirement that medical students are educated in emergencies and feel well prepared for practice as a doctor, yet national surveys show that many students feel underprepared. Virtual reality (VR), com...

    Authors: Risheka Walls, Priyanka Nageswaran, Adrian Cowell, Tunav Sehgal, Thomas White, James McVeigh, Stefan Staykov, Paul Basett, Daniel Mitelpunkt and Amir H. Sam
    Citation: BMC Medicine 2024 22:222
    Content type: Research article Published on:

  20. Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) are implicated in the aetiology of non-communicable diseases. Our study aimed to evaluate associations between NAFLD and MetS with overal...

    Authors: Ana-Lucia Mayén, Mirna Sabra, Elom K. Aglago, Gabriel Perlemuter, Cosmin Voican, Ines Ramos, Charlotte Debras, Jessica Blanco, Vivian Viallon, Pietro Ferrari, Anja Olsen, Anne Tjønneland, Fie Langmann, Christina C. Dahm, Joseph Rothwell, Nasser Laouali…
    Citation: BMC Medicine 2024 22:221
    Content type: Research article Published on:

  21. The patterns of blood pressure (BP) change throughout the pregnancy were related to adverse birth outcomes. However, little is known about the long-term effect of BP change patterns on child neurodevelopment. ...

    Authors: Luli Xu, Jiayi Cheng, Xiaohan Dong, Menglan Guo, Kai Chen, Xiaoxuan Fan, Xiaofeng Mu, Yuji Wang, Zhiguo Xia, Jun Li, Youjie Wang, Chao Xiong and Aifen Zhou
    Citation: BMC Medicine 2024 22:220
    Content type: Research article Published on:

  22. Although many individuals with alcohol dependence (AD) are recognized in the German healthcare system, only a few utilize addiction-specific treatment services. Those who enter treatment are not well character...

    Authors: Justin Möckl, Jakob Manthey, Monika Murawski, Christina Lindemann, Bernd Schulte, Jens Reimer, Oliver Pogarell and Ludwig Kraus
    Citation: BMC Medicine 2024 22:219
    Content type: Research article Published on:

  23. Deep brain stimulation (DBS) is a promising therapy for refractory Gilles de la Tourette syndrome (GTS). However, its long-term efficacy, safety, and recommended surgical age remain controversial, requiring ev...

    Authors: Yuan Gao, Shu Wang, Anni Wang, Shiying Fan, Yan Ge, Huimin Wang, Dongmei Gao, Jian Wang, Zhiqi Mao, Hulin Zhao, Hua Zhang, Lin Shi, Huanguang Liu, Guanyu Zhu, Anchao Yang, Yutong Bai…
    Citation: BMC Medicine 2024 22:218
    Content type: Research article Published on:

  25. In 2020, the Lancet Commission identified 12 risk factors as priorities for prevention of dementia, and other studies identified APOE e4/e4 genotype and family history of Alzheimer’s disease strongly associated w...

    Authors: Renhao Luo, Dena Zeraatkar, Maria Glymour, Randall J. Ellis, Hossein Estiri and Chirag J. Patel
    Citation: BMC Medicine 2024 22:216
    Content type: Research article Published on:

  26. Mucosal melanoma (MM) is a rare but devastating subtype of melanoma. Our previous studies have demonstrated robust anti-tumor effects of cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors in head and neck MM (HN...

    Authors: Chaoji Shi, Houyu Ju, Rong Zhou, Shengming Xu, Yunteng Wu, Ziyue Gu, Ying Wang, Wanling Chen, Xinyi Huang, Yong Han, Shuyang Sun, Chuwen Li, Min Wang, Guoyu Zhou, Zhiyuan Zhang, Jiang Li…
    Citation: BMC Medicine 2024 22:215
    Content type: Research article Published on:

  28. Prevalence of youth nicotine vaping has increased, heightening concerns around negative health effects. This study aimed to compare self-reported respiratory symptoms among youth by vaping behaviours.

    Authors: Leonie S. Brose, Jessica L. Reid, Debbie Robson, Ann McNeill and David Hammond
    Citation: BMC Medicine 2024 22:213
    Content type: Research article Published on:

  29. To examine the effectiveness and safety of a data sharing and comprehensive management platform for institutionalized older patients.

    Authors: Jung-Yeon Choi, Hongsoo Kim, Seungyeon Chun, Young-il Jung, Sooyoung Yoo, In-Hwan Oh, Gi-Soo Kim, Jin Young Ko, Jae-Young Lim, Minho Lee, Jongseon Lee and Kwang-il Kim
    Citation: BMC Medicine 2024 22:212
    Content type: Research article Published on:

  30. This study evaluates longitudinal associations between glycaemic control, measured by mean and within-patient variability of glycated haemaglobin (HbA1c) levels, and major depressive disorder (MDD) in individu...

    Authors: Alexandra C. Gillett, Saskia P. Hagenaars, Dale Handley, Francesco Casanova, Katherine G. Young, Harry Green, Cathryn M. Lewis and Jess Tyrrell
    Citation: BMC Medicine 2024 22:211
    Content type: Research article Published on:

  31. Healthy lifestyles are inversely associated with the risk of noncommunicable diseases, which are leading causes of death. However, few studies have used longitudinal data to assess the impact of changing lifes...

    Authors: Komodo Matta, Vivian Viallon, Edoardo Botteri, Giulia Peveri, Christina Dahm, Anne Østergaard Nannsen, Anja Olsen, Anne Tjønneland, Alexis Elbaz, Fanny Artaud, Chloé Marques, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Erand Llanaj, Giovanna Masala…
    Citation: BMC Medicine 2024 22:210
    Content type: Research article Published on:

  32. TG103, a glucagon-like peptide-1 analog, is being investigated as an option for weight management. We aimed to determine the safety, tolerability, pharmacokinetics, and pharmacodynamics of TG103 injection in p...

    Authors: Diaozhu Lin, Huisheng Xiao, Kexu Yang, Juan Li, Suiwen Ye, Yanqiong Liu, Shan Jing, Yang Lin, Yuanxun Yang, Lei Huang, Jing Yuan, Ziyan Li, Jinlan Yang, Huanhuan Gao, Ying Xie, Mingtong Xu…
    Citation: BMC Medicine 2024 22:209
    Content type: Research article Published on:

  33. Heavy menstrual bleeding (HMB) is a common menstrual disorder associated with multiple risk factors of cardiovascular disease (CVD) in women. In addition, HMB is often present with irregular menstruation (IM) ...

    Authors: Pallavi Dubey, Sireesha Reddy, Vishwajeet Singh, Abdelrehman Yousif and Alok Kumar Dwivedi
    Citation: BMC Medicine 2024 22:208
    Content type: Research article Published on:

  34. Tumor-infiltrating lymphocyte (TIL) therapy has been restricted by intensive lymphodepletion and high-dose intravenous interleukin-2 (IL-2) administration. To address these limitations, we conducted preclinica...

    Authors: Jing Guo, Chunyan Wang, Ning Luo, Yuliang Wu, Wei Huang, Jihui Zhu, Weihui Shi, Jinye Ding, Yao Ge, Chunhong Liu, Zhen Lu, Robert C. Bast Jr, Guihai Ai, Weihong Yang, Rui Wang, Caixia Li…
    Citation: BMC Medicine 2024 22:207
    Content type: Research article Published on:

  35. Numerous studies have been conducted to investigate the relationship between ABO and Rhesus (Rh) blood groups and various health outcomes. However, a comprehensive evaluation of the robustness of these associa...

    Authors: Fang-Hua Liu, Jia-Kai Guo, Wei-Yi Xing, Xue-Li Bai, Yu-Jiao Chang, Zhao Lu, Miao Yang, Ying Yang, Wen-Jing Li, Xian-Xian Jia, Tao Zhang, Jing Yang, Jun-Tong Chen, Song Gao, Lang Wu, De-Yu Zhang…
    Citation: BMC Medicine 2024 22:206
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Medicine 2024 22:291

  36. It is unclear whether brief interventions using the combined classification of alcohol-metabolizing enzymes aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) together with behavioral changes i...

    Authors: Yukiko Owaki, Hisashi Yoshimoto, Go Saito, Shohei Dobashi, Satoshi Kushio, Akihiro Nakamura, Takahiro Goto, Yusuke Togo, Kazumasa Mori and Hideki Hokazono
    Citation: BMC Medicine 2024 22:205
    Content type: Research article Published on:

  37. Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease, and its morbidity and mortality are increasing. At present, there is no specific therapy available. An exacerbat...

    Authors: Sai Wen, Nannan Xu, Lianhui Zhao, Lulu Yang, Hui Yang, Caiyun Chang, Shanshan Wang, Chunmei Qu, Li Song, Wenlu Zou, Yishan He and Gang Wang
    Citation: BMC Medicine 2024 22:204
    Content type: Research article Published on:

  38. To the best of our knowledge, no study has investigated the potential joint effect of large for gestational age (LGA) and assisted reproductive technology (ART) on the long-term health of children.

    Authors: Yiyuan Zhang, Kexin Dai, Xiaojing Chen, Linlin Cui and Zi-Jiang Chen
    Citation: BMC Medicine 2024 22:203
    Content type: Research article Published on:

  40. Lipid-lowering drugs and antihypertensive drugs are commonly combined for cardiovascular disease (CVD). However, the relationship of combined medications with CVD remains controversial. We aimed to explore the...

    Authors: Ying Li, Hongwei Liu, Chong Shen, Jianxin Li, Fangchao Liu, Keyong Huang, Dongfeng Gu, Yun Li and Xiangfeng Lu
    Citation: BMC Medicine 2024 22:201
    Content type: Research article Published on:

  41. Osteosarcoma (OS) is the most common primary malignant bone tumor and is highly prone to metastasis. OS can metastasize to the lymph node (LN) through the lymphatics, and the metastasis of tumor cells reestabl...

    Authors: Yun Liu, Mingwei He, Haijun Tang, Tianyu Xie, Yunhua Lin, Shangyu Liu, Jiming Liang, Feicui Li, Kai Luo, Mingxiu Yang, Hongcai Teng, Xiaoting Luo, Juliang He, Shijie Liao, Qian Huang, Wenyu Feng…
    Citation: BMC Medicine 2024 22:200
    Content type: Research article Published on:

  42. The prospective phase III multi-centre L-MOCA trial (NCT03534453) has demonstrated the encouraging efficacy and manageable safety profile of olaparib maintenance therapy in the Asian (mainly Chinese) patients ...

    Authors: Huayi Li, Zikun Peng, Jianqing Zhu, Weidong Zhao, Yi Huang, Ruifang An, Hong Zheng, Pengpeng Qu, Li Wang, Qi Zhou, Danbo Wang, Ge Lou, Jing Wang, Ke Wang, Beihua Kong, Xing Xie…
    Citation: BMC Medicine 2024 22:199
    Content type: Research article Published on:

  43. In the context of expanding digital health tools, the health system is ready for Learning Health System (LHS) models. These models, with proper governance and stakeholder engagement, enable the integration of ...

    Authors: Helena Teede, Dominique A. Cadilhac, Tara Purvis, Monique F. Kilkenny, Bruce C.V. Campbell, Coralie English, Alison Johnson, Emily Callander, Rohan S. Grimley, Christopher Levi, Sandy Middleton, Kelvin Hill and Joanne Enticott
    Citation: BMC Medicine 2024 22:198
    Content type: Opinion Published on:

  44. The aim of this study was to evaluate commonly assumed causal relationships between body mass index (BMI), gestational weight gain (GWG), and adverse pregnancy outcomes, which have formed the basis of guidelin...

    Authors: Jodie M. Dodd, Jennie Louise, Andrea R. Deussen, Megan Mitchell and Lucilla Poston
    Citation: BMC Medicine 2024 22:197
    Content type: Research article Published on:

  45. Mobile health (mHealth) technologies have been harnessed in low- and middle-income countries (LMICs) to address the intricate challenges confronting maternal, newborn, and child health (MNCH). This review aspi...

    Authors: Marianne Ravn Knop, Michiko Nagashima-Hayashi, Ruixi Lin, Chan Hang Saing, Mengieng Ung, Sreymom Oy, Esabelle Lo Yan Yam, Marina Zahari and Siyan Yi
    Citation: BMC Medicine 2024 22:196
    Content type: Review Published on:

  46. Diabetic cardiomyopathy (DbCM) is characterized by asymptomatic stage B heart failure (SBHF) caused by diabetes-related metabolic alterations. DbCM is associated with an increased risk of progression to overt ...

    Authors: Iwona Swiatkiewicz, Neeja T. Patel, MaryAnn Villarreal-Gonzalez and Pam R. Taub
    Citation: BMC Medicine 2024 22:195
    Content type: Research article Published on:

  47. The reason for higher incidence of atrial fibrillation (AF) in Europe compared with East Asia is unclear. We aimed to investigate the association between modifiable lifestyle factors and lifetime risk of AF in...

    Authors: Hanjin Park, Daehoon Kim, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Dong-min Kim, Jung-Hoon Sung, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y. H. Lip, Pil-Sung Yang and Boyoung Joung
    Citation: BMC Medicine 2024 22:194
    Content type: Research article Published on:

  48. Antidepressants are first-line medications for many psychiatric disorders. However, their widespread long-term use in some indications (e.g., mild depression and insomnia) is concerning. Particularly in older ...

    Authors: Vita Brisnik, Jochen Vukas, Caroline Jung-Sievers, Karoline Lukaschek, G Caleb Alexander, Ulrich Thiem, Petra Thürmann, Cornelius Schüle, Sebastian Fischer, Erika Baum, Michael Drey, Sebastian Harder, Wilhelm Niebling, Ulrike Janka, Olaf Krause, Jochen Gensichen…
    Citation: BMC Medicine 2024 22:193
    Content type: Research article Published on:

  49. Peripheral glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) are sensitive markers of neuroinflammation and neuronal damage. Previous studies with highly selected participants have sho...

    Authors: Xiaofei Wang, Ziyan Shi, Yuhan Qiu, Dongren Sun and Hongyu Zhou
    Citation: BMC Medicine 2024 22:192
    Content type: Research article Published on:

  50. Healthy Start (HS) is a government scheme in England, Wales and Northern Ireland that offers a financial payment card and free vitamins to families experiencing low income. Pregnant women and families with chi...

    Authors: Millie Barrett, Mark Spires and Christina Vogel
    Citation: BMC Medicine 2024 22:177
    Content type: Research article Published on:
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