Skip to main content

Articles

Page 4 of 73

  1. Circulating levels of amino acids were associated with blood pressure (BP) in observational studies. However, the causation of such associations has been hypothesized but is difficult to prove in human studies...

    Authors: Chenhao Lin, Zhonghan Sun, Zhendong Mei, Hailuan Zeng, Manying Zhao, Jianying Hu, Mingfeng Xia, Tao Huang, Chaolong Wang, Xin Gao and Yan Zheng
    Citation: BMC Medicine 2022 20:414
  2. Parkinson’s disease (PD) is the second most common neurodegenerative disease in middle-aged and elderly populations, whereas there is no cure for PD so far. Novel animal models and medications await developmen...

    Authors: Jiangbo Song, Lian Liu, Zhiquan Li, Ting Mao, Jianfei Zhang, Lei Zhou, Xin Chen, Yunzhu Shang, Tao Sun, Yuxin Luo, Yu Jiang, Duan Tan, Xiaoling Tong and Fangyin Dai
    Citation: BMC Medicine 2022 20:412
  3. The application of combination therapy for cancer treatment is limited due to poor tumor-specific drug delivery and the abscopal effect.

    Authors: Yibin Cheng, Caixia Wang, Huihui Wang, Zhiwei Zhang, Xiaopeng Yang, Yanming Dong, Lixin Ma and Jingwen Luo
    Citation: BMC Medicine 2022 20:411
  4. Pragmatic trials aim to generate evidence to directly inform patient, caregiver and health-system manager policies and decisions. Heterogeneity in patient characteristics contributes to heterogeneity in their ...

    Authors: Bruno Giraudeau, Agnès Caille, Sandra M. Eldridge, Charles Weijer, Merrick Zwarenstein and Monica Taljaard
    Citation: BMC Medicine 2022 20:372
  5. Type 2 diabetes mellitus (T2DM) is one of the most widely spread diseases, affecting around 90% of the patients with diabetes. Metabolomics has proven useful in diabetes research discovering new biomarkers to ...

    Authors: Marina Mora-Ortiz, Juan F. Alcala-Diaz, Oriol Alberto Rangel-Zuñiga, Antonio Pablo Arenas-de Larriva, Fernando Abollo-Jimenez, Diego Luque-Cordoba, Feliciano Priego-Capote, Maria M. Malagon, Javier Delgado-Lista, Jose M. Ordovas, Pablo Perez-Martinez, Antonio Camargo and Jose Lopez-Miranda
    Citation: BMC Medicine 2022 20:373
  6. Although guidelines recommend lipid injectable emulsions (ILEs) be used as a part of parenteral nutrition, many patients in Japan receive lipid-free parenteral nutrition. Furthermore, little is known about the...

    Authors: Kosei Takagi, Kenta Murotani, Satoru Kamoshita and Akiyoshi Kuroda
    Citation: BMC Medicine 2022 20:371
  7. Observational studies support a role for oral anticoagulation to reduce the risk of dementia in atrial fibrillation patients, but conclusive data are lacking. Since dabigatran offers a more stable anticoagulat...

    Authors: Bruno Caramelli, Pai Ching Yu, Francisco A. M. Cardozo, Iuri R. Magalhães, Raphael R. Spera, Daniel K. Amado, Maria C. Escalante-Rojas, Danielle M. Gualandro, Daniela Calderaro, Caio A. M. Tavares, Flavio A. Borges-Junior, Adriana F. Pastana, Mariana G. Matheus, Sonia M. D. Brucki, Ana Carolina O. Rodrigues, Ricardo Nitrini…
    Citation: BMC Medicine 2022 20:374
  8. Chronic kidney disease patients are at increased risk of mortality with cardiovascular diseases and infections as the two leading causes of death for end-stage kidney disease treated with hemodialysis (HD). Mo...

    Authors: Salti Talal, Khoury Mona, Awad Karem, Lerenthal Yaniv, Harari-Misgav Reut, Shemesh Ariel, Avraham-Kelbert Moran, Eitam Harel, Salvatore Campisi-Pinto, Abu-Amna Mahmoud, Colodner Raul, Tovbin David, Bar-Sela Gil and Cohen Idan
    Citation: BMC Medicine 2022 20:364
  9. Dose fractionation of a coronavirus disease 2019 (COVID-19) vaccine could effectively accelerate global vaccine coverage, while supporting evidence of efficacy, immunogenicity, and safety are unavailable, espe...

    Authors: Bingyi Yang, Xiaotong Huang, Huizhi Gao, Nancy H. Leung, Tim K. Tsang and Benjamin J. Cowling
    Citation: BMC Medicine 2022 20:409
  10. Dual inhibition of PD-1/PD-L1 and TGF-β pathways is a rational therapeutic strategy for malignancies. SHR-1701 is a new bifunctional fusion protein composed of a monoclonal antibody against PD-L1 fused with th...

    Authors: Dan Liu, Jun Zhou, Yongsheng Wang, Mingjun Li, Haiping Jiang, Yunpeng Liu, Xianli Yin, Minghua Ge, Xiaojun Xiang, Jieer Ying, Jian Huang, Yan-qiao Zhang, Ying Cheng, Zhigang Huang, Xianglin Yuan, Weiqing Han…
    Citation: BMC Medicine 2022 20:408
  11. For hypertensive patients without a history of stroke or myocardial infarction (MI), the China Stroke Primary Prevention Trial (CSPPT) demonstrated that treatment with enalapril-folic acid reduced the risk of ...

    Authors: Tiantian Zhang, Zhuoru Liang, Tengfei Lin, David J. Cohen, Alejandro Arrieta, Xiaobin Wang, Xianhui Qin, Binyan Wang, Yong Huo, Gordon G. Liu, Jie Jiang and Zugui Zhang
    Citation: BMC Medicine 2022 20:407
  12. Circulating tumor DNA (ctDNA) has been proven to be a promising tumor-specific biomarker in solid tumors, but its clinical utility in risk stratification and early prediction of relapse for diffuse large B cel...

    Authors: Miaomiao Li, Lan Mi, Chunyang Wang, Xiaojuan Wang, Jianhua Zhu, Fei Qi, Hui Yu, Yingying Ye, Dedao Wang, Jiaowu Cao, Dingyao Hu, Quanyu Yang, Dandan Zhao, Tonghui Ma, Yuqin Song and Jun Zhu
    Citation: BMC Medicine 2022 20:369
  13. Abnormal metabolism and perturbations in metabolic pathways play significant roles in the development and progression of prostate cancer; however, comprehensive metabolomic analyses of human data are lacking a...

    Authors: Jiaqi Huang, Bin Zhao, Stephanie J. Weinstein, Demetrius Albanes and Alison M. Mondul
    Citation: BMC Medicine 2022 20:362
  14. The diagnostic accuracy of unsupervised self-testing with rapid antigen diagnostic tests (Ag-RDTs) is mostly unknown. We studied the diagnostic accuracy of a self-performed SARS-CoV-2 saliva and nasal Ag-RDT i...

    Authors: Ewoud Schuit, Roderick P. Venekamp, Irene K. Veldhuijzen, Wouter van den Bijllaardt, Suzan D. Pas, Joep J. J. M. Stohr, Esther B. Lodder, Marloes Hellwich, Richard Molenkamp, Zsofia Igloi, Constantijn Wijers, Irene H. Vroom, Carla R. S. Nagel-Imming, Wanda G. H. Han, Jan A. J. W. Kluytmans, Susan van den Hof…
    Citation: BMC Medicine 2022 20:406
  15. The ongoing opioid epidemic and increases in alcohol-related mortality are key public health concerns in the USA, with well-documented inequalities in the degree to which groups with low and high education are...

    Authors: Charlotte Buckley, Yu Ye, William C. Kerr, Nina Mulia, Klajdi Puka, Jürgen Rehm and Charlotte Probst
    Citation: BMC Medicine 2022 20:405
  16. Parallel to growth of aging and obese populations, the prevalence of metabolic diseases is rising. How body mass index (BMI) relates to frailty and mortality across frailty levels is controversial. We examined...

    Authors: Kulapong Jayanama, Olga Theou, Judith Godin, Andrea Mayo, Leah Cahill and Kenneth Rockwood
    Citation: BMC Medicine 2022 20:404
  17. Although neoadjuvant anti-PD-1 immunotherapies have shown good efficacy in non-small cell lung cancer (NSCLC) patients, there is still a lack of effective predictive markers. We aimed to develop a pretreatment...

    Authors: Pei Yuan, Changyuan Guo, Lin Li, Yun Ling, Lei Guo and Jianming Ying
    Citation: BMC Medicine 2022 20:403
  18. To investigate whether metformin monotherapy or adjunctive therapy improves the prognosis in patients with any type of cancer compared to non-metformin users (age ≥18).

    Authors: Jie Wen, Zhenjie Yi, Yuyao Chen, Jing Huang, Xueyi Mao, Liyang Zhang, Yu Zeng, Quan Cheng, Wenrui Ye, Zhixiong Liu, Fangkun Liu and Jingfang Liu
    Citation: BMC Medicine 2022 20:402
  19. Structured and harmonized implementation of molecular tumor boards (MTB) for the clinical interpretation of molecular data presents a current challenge for precision oncology. Heterogeneity in the interpretati...

    Authors: Damian T. Rieke, Till de Bortoli, Peter Horak, Mario Lamping, Manuela Benary, Ivan Jelas, Gina Rüter, Johannes Berger, Marit Zettwitz, Niklas Kagelmann, Andreas Kind, Falk Fabian, Dieter Beule, Hanno Glimm, Benedikt Brors, Albrecht Stenzinger…
    Citation: BMC Medicine 2022 20:367
  20. Randomized controlled trials (RCTs) and cohort studies are the most common study design types used to assess treatment effects of medical interventions. We aimed to hypothetically pool bodies of evidence (BoE)...

    Authors: Nils Bröckelmann, Julia Stadelmaier, Louisa Harms, Charlotte Kubiak, Jessica Beyerbach, Martin Wolkewitz, Jörg J. Meerpohl and Lukas Schwingshackl
    Citation: BMC Medicine 2022 20:355
  21. The severe fever with thrombocytopenia syndrome disease (SFTS), caused by the novel tick-borne SFTS virus (SFTSV), was listed among the top 10 priority infectious disease by World Health Organization due to th...

    Authors: Shu Shen, Yaxian Zhang, Zhiyun Yin, Qiong Zhu, Jingyuan Zhang, Tiantian Wang, Yaohui Fang, Xiaoli Wu, Yuan Bai, Shiyu Dai, Xijia Liu, Jiayin Jin, Shuang Tang, Jia Liu, Manli Wang, Yu Guo…
    Citation: BMC Medicine 2022 20:359
  22. Authors: Amadea Turk, Geoffrey Wong, Kamal R. Mahtani, Michelle Maden, Ruaraidh Hill, Ed Ranson, Emma Wallace, Janet Krska, Dee Mangin, Richard Byng, Daniel Lasserson and Joanne Reeve
    Citation: BMC Medicine 2022 20:401

    The original article was published in BMC Medicine 2022 20:297

  23. Limited data are available on the effectiveness of inactivated and Ad5-nCoV COVID-19 vaccines in real-world use—especially against Omicron variants in SARS-CoV-2 infection-naïve population.

    Authors: Zhuoying Huang, Shuangfei Xu, Jiechen Liu, Linlin Wu, Jing Qiu, Nan Wang, Jia Ren, Zhi Li, Xiang Guo, Fangfang Tao, Jian Chen, Donglei Lu, Xiaodong Sun and Weibing Wang
    Citation: BMC Medicine 2022 20:400
  24. Reduced androgen action during early fetal development has been suggested as the origin of reproductive disorders comprised within the testicular dysgenesis syndrome (TDS). This hypothesis has been supported b...

    Authors: Malene Lundgaard Riis, Gabriele Matilionyte, John E. Nielsen, Cecilie Melau, David Greenald, Kristine Juul Hare, Lea Langhoff Thuesen, Eva Dreisler, Kasper Aaboe, Pia Tutein Brenøe, Anna-Maria Andersson, Jakob Albrethsen, Hanne Frederiksen, Ewa Rajpert-De Meyts, Anders Juul, Rod T. Mitchell…
    Citation: BMC Medicine 2022 20:399
  25. Maternal blood pressure levels reflect cardiovascular adaptation to pregnancy and proper maternal-fetal exchanges through the placenta and are very sensitive to numerous environmental stressors. Maternal hyper...

    Authors: Lucile Broséus, Daniel Vaiman, Jörg Tost, Camino Ruano San Martin, Milan Jacobi, Joel D. Schwartz, Rémi Béranger, Rémy Slama, Barbara Heude and Johanna Lepeule
    Citation: BMC Medicine 2022 20:397
  26. Health information and patient education on lifestyle changes may have a positive effect on the prevention of many chronic conditions, especially cardiovascular diseases (CVDs). We performed a parallel, three-...

    Authors: Slavica Jurić Petričević, Ivan Buljan, Dora Bjelanović, Nataša Mrduljaš-Đujić, Tanja Pekez, Mario Ćurković, Željko Vojvodić, Ivančica Pavličević, Matko Marušić and Ana Marušić
    Citation: BMC Medicine 2022 20:381
  27. The benefits and risks of intensive versus standard systolic blood pressure (SBP) treatment in older patients with arterial stiffness (AS) remains unclear. This study aims to investigate the interaction betwee...

    Authors: Qirui Song, Qianhui Ling, Jingjing Bai, Hongwei Zhang, Peili Bu, Fang Chen, Shouling Wu, Weili Zhang, Mulei Chen and Jun Cai
    Citation: BMC Medicine 2022 20:358
  28. Radiotherapy (RT) is one of the major therapeutic approaches to hepatocellular carcinoma (HCC). Ionizing radiation (IR) inducing the generation of reactive oxygen species (ROS) leads to a promising antitumor e...

    Authors: Yizhi Zhan, Zhanqiao Zhang, Yuechen Liu, Yuan Fang, Yuwen Xie, Yilin Zheng, Guoxin Li, Li Liang and Yi Ding
    Citation: BMC Medicine 2022 20:365
  29. Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metaboli...

    Authors: Marie Breeur, Pietro Ferrari, Laure Dossus, Mazda Jenab, Mattias Johansson, Sabina Rinaldi, Ruth C. Travis, Mathilde His, Tim J. Key, Julie A. Schmidt, Kim Overvad, Anne Tjønneland, Cecilie Kyrø, Joseph A. Rothwell, Nasser Laouali, Gianluca Severi…
    Citation: BMC Medicine 2022 20:351
  30. Acute febrile respiratory illness (AFRI) patients are susceptible to pneumonia and suffer from significant morbidity and mortality throughout the world. In primary care settings, the situation is worse. Limite...

    Authors: Fengming Ding, Lei Han, Dongning Yin, Yan Zhou, Yong Ji, Pengyu Zhang, Wensheng Wu, Jijing Chen, Zufang Wang, Xinxin Fan, Guoqing Zhang and Min Zhang
    Citation: BMC Medicine 2022 20:360
  31. The prevention of type 2 diabetes is challenging due to the variable effects of risk factors at an individual level. Data-driven methods could be useful to detect more homogeneous groups based on risk factor v...

    Authors: Diego Yacamán Méndez, Minhao Zhou, Ylva Trolle Lagerros, Donaji V. Gómez Velasco, Per Tynelius, Hrafnhildur Gudjonsdottir, Antonio Ponce de Leon, Katarina Eeg-Olofsson, Claes-Göran Östenson, Boel Brynedal, Carlos A. Aguilar Salinas, David Ebbevi and Anton Lager
    Citation: BMC Medicine 2022 20:356
  32. Considering the heterogeneity of tumors, it is a key issue in precision medicine to predict the drug response of each individual. The accumulation of various types of drug informatics and multi-omics data faci...

    Authors: Xiaoxiao Cheng, Chong Dai, Yuqi Wen, Xiaoqi Wang, Xiaochen Bo, Song He and Shaoliang Peng
    Citation: BMC Medicine 2022 20:368
  33. Extraintestinal symptoms are common in inflammatory bowel diseases (IBD) and include depression and fatigue. These are highly prevalent especially in active disease, potentially due to inflammation-mediated ch...

    Authors: Anne Kerstin Thomann, Torsten Wüstenberg, Jakob Wirbel, Laura-Louise Knoedler, Philipp Arthur Thomann, Georg Zeller, Matthias Philip Ebert, Stefanie Lis and Wolfgang Reindl
    Citation: BMC Medicine 2022 20:366
  34. In view of accumulating case reports of thyroid dysfunction following COVID-19 vaccination, we evaluated the risks of incident thyroid dysfunction following inactivated (CoronaVac) and mRNA (BNT162b2) COVID-19...

    Authors: Carlos King Ho Wong, David Tak Wai Lui, Xi Xiong, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Xue Li, Eric Yuk Fai Wan, Ching Lung Cheung, Chi Ho Lee, Yu Cho Woo, Ivan Chi Ho Au, Matthew Shing Hin Chung, Franco Wing Tak Cheng, Kathryn Choon Beng Tan and Ian Chi Kei Wong
    Citation: BMC Medicine 2022 20:339
  35. This study evaluated the persistence of IgM, IgA, and IgG to SARS-CoV-2 spike and nucleocapsid antigens up to 616 days since the onset of symptoms in a longitudinal cohort of 247 primary health care workers fr...

    Authors: Carlota Dobaño, Anna Ramírez-Morros, Selena Alonso, Rocío Rubio, Gemma Ruiz-Olalla, Josep Vidal-Alaball, Dídac Macià, Queralt Miró Catalina, Marta Vidal, Aina Fuster Casanovas, Esther Prados de la Torre, Diana Barrios, Alfons Jiménez, Jasmina Zanoncello, Natalia Rodrigo Melero, Carlo Carolis…
    Citation: BMC Medicine 2022 20:379
  36. The prevalence of some immune-mediated diseases (IMDs) shows distinct differences between populations of different ethnicities. The aim of this study was to determine if the age at diagnosis of common IMDs als...

    Authors: Archana Sharma-Oates, Dawit T. Zemedikun, Kanta Kumar, John A. Reynolds, Avinash Jain, Karim Raza, John A. Williams, Laura Bravo, Victor Roth Cardoso, Georgios Gkoutos, Krishnarajah Nirantharakumar and Janet M. Lord
    Citation: BMC Medicine 2022 20:346
  37. Current guidelines recommend rhythm control for improving symptoms and quality of life in symptomatic patients with atrial fibrillation (AF). However, the long-term prognostic outcomes of rhythm control compar...

    Authors: Wengen Zhu, Zexuan Wu, Yugang Dong, Gregory Y. H. Lip and Chen Liu
    Citation: BMC Medicine 2022 20:340
  38. Cervical insufficiency is one of the underlying causes of late miscarriage and preterm birth. Although many risk factors have been identified, the relative magnitude of their association with risk in nulliparo...

    Authors: Lili Meng, Sara Öberg, Anna Sandström, Chen Wang and Marie Reilly
    Citation: BMC Medicine 2022 20:348
  39. Early in the COVID-19 pandemic, countries adopted non-pharmaceutical interventions (NPIs) such as lockdowns to limit SARS-CoV-2 transmission. Social contact studies help measure the effectiveness of NPIs and e...

    Authors: Zlatina Dobreva, Amy Gimma, Hana Rohan, Benjamin Djoudalbaye, Akhona Tshangela, Christopher I. Jarvis, Kevin van Zandvoort and Matthew Quaife
    Citation: BMC Medicine 2022 20:344
  40. To prevent child deaths from severe malaria, early parenteral treatment is essential. Yet, in remote rural areas, accessing facilities offering parenteral antimalarials may be difficult. A randomised controlle...

    Authors: Manuel W. Hetzel, Jean Okitawutshu, Antoinette Tshefu, Elizabeth Omoluabi, Phyllis Awor, Aita Signorell, Nina C. Brunner, Jean-Claude Kalenga, Babatunde K. Akano, Kazeem Ayodeji, Charles Okon, Ocheche Yusuf, Proscovia Athieno, Joseph Kimera, Gloria Tumukunde, Irene Angiro…
    Citation: BMC Medicine 2022 20:343
  41. Instruments to critically appraise randomised controlled trials (RCTs) are based on evidence from meta-epidemiological studies. We aim to conduct a meta-epidemiological study on the average bias associated wit...

    Authors: Julia Stadelmaier, Isabelle Roux, Maria Petropoulou and Lukas Schwingshackl
    Citation: BMC Medicine 2022 20:330
  42. Regular vaccination against SARS-CoV-2 may be needed to maintain immunity in ‘at-risk’ populations, which include healthcare workers (HCWs). However, little is known about the proportion of HCWs who might be h...

    Authors: Neyme Veli, Christopher A. Martin, Katherine Woolf, Joshua Nazareth, Daniel Pan, Amani Al-Oraibi, Rebecca F. Baggaley, Luke Bryant, Laura B. Nellums, Laura J. Gray, Kamlesh Khunti and Manish Pareek
    Citation: BMC Medicine 2022 20:386
  43. Antiretroviral therapy (ART) adherence is still suboptimal among some key populations, highlighting the need for innovative tailored strategies. This randomized controlled trial (RCT) aimed to evaluate the eff...

    Authors: Kedi Jiao, Chunmei Wang, Meizhen Liao, Jing Ma, Dianmin Kang, Weiming Tang, Joseph D. Tucker and Wei Ma
    Citation: BMC Medicine 2022 20:341
  44. Diabetic kidney disease (DKD), the most common cause of kidney failure and end-stage kidney disease worldwide, will develop in almost half of all people with type 2 diabetes. With the incidence of type 2 diabe...

    Authors: Thomas Forst, Chantal Mathieu, Francesco Giorgino, David C. Wheeler, Nikolaos Papanas, Roland E. Schmieder, Atef Halabi, Oliver Schnell, Marina Streckbein and Katherine R. Tuttle
    Citation: BMC Medicine 2022 20:337
  45. Varicella zoster virus (VZV) is one of the eight known human herpesviruses. Initial VZV infection results in chickenpox, while viral reactivation following a period of latency manifests as shingles. Separate v...

    Authors: Kevin M Bakker, Marisa C Eisenberg, Robert J Woods and Micaela E Martinez
    Citation: BMC Medicine 2022 20:387
  46. A recent trial of 5920 children in Burkina Faso and Mali showed that the combination of seasonal vaccination with the RTS,S/AS01E malaria vaccine (primary series and two seasonal boosters) and seasonal malaria ch...

    Authors: Matthew Cairns, Amadou Barry, Issaka Zongo, Issaka Sagara, Serge R. Yerbanga, Modibo Diarra, Charles Zoungrana, Djibrilla Issiaka, Abdoul Aziz Sienou, Amadou Tapily, Koualy Sanogo, Mahamadou Kaya, Seydou Traore, Kalifa Diarra, Hama Yalcouye, Youssoufa Sidibe…
    Citation: BMC Medicine 2022 20:352
  47. Up to one of every six individuals diagnosed with one cancer will be diagnosed with a second primary cancer in their lifetime. Genetic factors contributing to the development of multiple primary cancers, beyon...

    Authors: Taylor B. Cavazos, Linda Kachuri, Rebecca E. Graff, Jovia L. Nierenberg, Khanh K. Thai, Stacey Alexeeff, Stephen Van Den Eeden, Douglas A. Corley, Lawrence H. Kushi, Thomas J. Hoffmann, Elad Ziv, Laurel A. Habel, Eric Jorgenson, Lori C. Sakoda and John S. Witte
    Citation: BMC Medicine 2022 20:332