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  1. Content type: Opinion

    Various Zika virus (ZIKV) vaccine candidates are currently in development. Nevertheless, unique challenges in clinical development and regulatory pathways may hinder the licensure of high-quality, safe, and ef...

    Authors: Annelies Wilder-Smith, Kirsten Vannice, Anna Durbin, Joachim Hombach, Stephen J. Thomas, Irani Thevarjan and Cameron P. Simmons

    Citation: BMC Medicine 2018 16:84

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  2. Content type: Minireview

    In real-world clinical practice, the acceptance of anticoagulation therapy in the management of portal vein thrombosis (PVT) in patients with cirrhosis is limited by the fear of an increased bleeding risk. Add...

    Authors: Xingshun Qi, Xiaozhong Guo, Eric M. Yoshida, Nahum Méndez-Sánchez, Valerio De Stefano, Frank Tacke, Andrea Mancuso, Yasuhiko Sugawara, Sien-Sing Yang, Rolf Teschke, Ankur Arora and Dominique-Charles Valla

    Citation: BMC Medicine 2018 16:83

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  3. Content type: Commentary

    The increasing number and global distribution of pathogens resistant to antimicrobial drugs is potentially one of the greatest threats to global health, leading to health crises arising from infections that we...

    Authors: Simon I. Hay, Puja C. Rao, Christiane Dolecek, Nicholas P. J. Day, Andy Stergachis, Alan D. Lopez and Christopher J. L. Murray

    Citation: BMC Medicine 2018 16:78

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  4. Content type: Research article

    Despite decades of experience with praziquantel treatment in school-aged children (SAC) and adults, we still face considerable knowledge gaps relevant to the successful treatment of preschool-aged children (PS...

    Authors: Jean T. Coulibaly, Gordana Panic, Richard B. Yapi, Jana Kovač, Beatrice Barda, Yves K. N’Gbesso, Jan Hattendorf and Jennifer Keiser

    Citation: BMC Medicine 2018 16:81

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  5. Content type: Research article

    Innovative ways of delivering care are needed to improve outcomes for older people with multimorbidity. Health coaching involves ‘a regular series of phone calls between patient and health professional to prov...

    Authors: Maria Panagioti, David Reeves, Rachel Meacock, Beth Parkinson, Karina Lovell, Mark Hann, Kelly Howells, Amy Blakemore, Lisa Riste, Peter Coventry, Thomas Blakeman, Mark Sidaway and Peter Bower

    Citation: BMC Medicine 2018 16:80

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  6. Content type: Research article

    The CD4/CD8 ratio has been associated with the risk of AIDS and non-AIDS events. We describe trends in immunological parameters in people who underwent a switch to monotherapy or dual therapy, compared to a co...

    Authors: Cristina Mussini, Patrizia Lorenzini, Alessandro Cozzi-Lepri, Giulia Marchetti, Stefano Rusconi, Andrea Gori, Silvia Nozza, Miriam Lichtner, Andrea Antinori, Andrea Cossarizza and Antonella d’Arminio Monforte

    Citation: BMC Medicine 2018 16:79

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  7. Content type: Research article

    The relationship between long-term exposure to whole body or central obesity and cognitive function, as well as its potential determinants, remain controversial. In this study, we assessed (1) the potential im...

    Authors: Stefano Masi, Georgios Georgiopoulos, Tauseef Khan, William Johnson, Andrew Wong, Marietta Charakida, Peter Whincup, Alun D. Hughes, Marcus Richards, Rebecca Hardy and John Deanfield

    Citation: BMC Medicine 2018 16:75

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  8. Content type: Research article

    The appropriate limit to the amount of daily sedentary time (ST) required to minimize mortality is uncertain. This meta-analysis aimed to quantify the dose-response association between daily ST and all-cause m...

    Authors: Po-Wen Ku, Andrew Steptoe, Yung Liao, Ming-Chun Hsueh and Li-Jung Chen

    Citation: BMC Medicine 2018 16:74

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  9. Content type: Research article

    Discretionary screen time (time spent viewing a television or computer screen during leisure time) is an important contributor to total sedentary behaviour, which is associated with increased risk of mortality...

    Authors: Carlos A. Celis-Morales, Donald M. Lyall, Lewis Steell, Stuart R. Gray, Stamatina Iliodromiti, Jana Anderson, Daniel F. Mackay, Paul Welsh, Thomas Yates, Jill P. Pell, Naveed Sattar and Jason M. R. Gill

    Citation: BMC Medicine 2018 16:77

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  10. Content type: Research article

    Reliable measures of disease burden over time are necessary to evaluate the impact of interventions and assess sub-national trends in the distribution of infection. Three Malaria Indicator Surveys (MISs) have ...

    Authors: Su Yun Kang, Katherine E. Battle, Harry S. Gibson, Arsène Ratsimbasoa, Milijaona Randrianarivelojosia, Stéphanie Ramboarina, Peter A. Zimmerman, Daniel J. Weiss, Ewan Cameron, Peter W. Gething and Rosalind E. Howes

    Citation: BMC Medicine 2018 16:71

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  11. Content type: Research article

    Effective coverage requires that those in need can access skilled care supported by adequate resources. There are, however, few studies of effective coverage of facility-based neonatal care in low-income setti...

    Authors: Georgina A. V. Murphy, David Gathara, Jacintah Mwachiro, Nancy Abuya, Jalemba Aluvaala and Mike English

    Citation: BMC Medicine 2018 16:72

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  12. Content type: Research article

    Chest radiographs are used for diagnosis and severity assessment in tuberculosis (TB). The extent of disease as determined by smear grade and cavitation as a binary measure can predict 2-month smear results, b...

    Authors: S. E. Murthy, F. Chatterjee, A. Crook, R. Dawson, C. Mendel, M. E. Murphy, S. R. Murray, A. J. Nunn, P. P. J. Phillips, Kasha P. Singh, T. D. McHugh and S. H. Gillespie

    Citation: BMC Medicine 2018 16:73

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  13. Content type: Research article

    Previous studies on high-risk opioid use have only focused on patients diagnosed with an opioid disorder. This study evaluates the impact of various high-risk prescription opioid use groups on healthcare costs...

    Authors: Hsien-Yen Chang, Hadi Kharrazi, Dave Bodycombe, Jonathan P. Weiner and G. Caleb Alexander

    Citation: BMC Medicine 2018 16:69

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  14. Content type: Research article

    Countries with ongoing outbreaks of Zika virus have observed a notable rise in reported cases of Guillain–Barré syndrome (GBS), with mounting evidence of a causal link between Zika virus infection and the neur...

    Authors: Luis Mier-y-Teran-Romero, Mark J. Delorey, James J. Sejvar and Michael A. Johansson

    Citation: BMC Medicine 2018 16:67

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  15. Content type: Research article

    Failures and partial successes are common in technology-supported innovation programmes in health and social care. Complexity theory can help explain why. Phenomena may be simple (straightforward, predictable,...

    Authors: Trisha Greenhalgh, Joe Wherton, Chrysanthi Papoutsi, Jenni Lynch, Gemma Hughes, Christine A’Court, Sue Hinder, Rob Procter and Sara Shaw

    Citation: BMC Medicine 2018 16:66

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  16. Content type: Opinion

    After 7 years of increasing conflict and violence, the Syrian civil war now constitutes the largest displacement crisis in the world, with more than 6 million people who have been internally displaced. Among t...

    Authors: Rahma Aburas, Amina Najeeb, Laila Baageel and Tim K. Mackey

    Citation: BMC Medicine 2018 16:65

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  17. Content type: Research article

    The Daily Mile is a physical activity programme made popular by a school in Stirling, Scotland. It is promoted by the Scottish Government and is growing in popularity nationally and internationally. The aim is...

    Authors: Ross A. Chesham, Josephine N. Booth, Emma L. Sweeney, Gemma C. Ryde, Trish Gorely, Naomi E. Brooks and Colin N. Moran

    Citation: BMC Medicine 2018 16:64

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  18. Content type: Research article

    Many clinical trials conducted by academic organizations are not published, or are not published completely. Following the US Food and Drug Administration Amendments Act of 2007, “The Final Rule” (compliance d...

    Authors: Evan Mayo-Wilson, James Heyward, Anthony Keyes, Jesse Reynolds, Sarah White, Nidhi Atri, G. Caleb Alexander, Audrey Omar and Daniel E. Ford

    Citation: BMC Medicine 2018 16:60

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  19. Content type: Research article

    Little is known about the impact of growing migration on the pattern of tuberculosis (TB) transmission in middle-income countries. We estimated TB recent transmission and its associated factors and investigate...

    Authors: Julia Moreira Pescarini, Vera Simonsen, Lucilaine Ferrazoli, Laura C. Rodrigues, Rosangela S. Oliveira, Eliseu Alves Waldman and Rein Houben

    Citation: BMC Medicine 2018 16:62

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  20. Content type: Opinion

    Implementation science has a core aim – to get evidence into practice. Early in the evidence-based medicine movement, this task was construed in linear terms, wherein the knowledge pipeline moved from evidence...

    Authors: Jeffrey Braithwaite, Kate Churruca, Janet C. Long, Louise A. Ellis and Jessica Herkes

    Citation: BMC Medicine 2018 16:63

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  21. Content type: Research article

    Antibodies targeting Plasmodium falciparum sporozoites play a key role in human immunity to malaria. However, antibody mechanisms that neutralize sporozoites are poorly understood. This has been a major constrain...

    Authors: Liriye Kurtovic, Marije C. Behet, Gaoqian Feng, Linda Reiling, Kiprotich Chelimo, Arlene E. Dent, Ivo Mueller, James W. Kazura, Robert W. Sauerwein, Freya J. I. Fowkes and James G. Beeson

    Citation: BMC Medicine 2018 16:61

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  22. Content type: Research article

    Methylene blue (MB) was the first synthetic antimalarial to be discovered and was used during the late 19th and early 20th centuries against all types of malaria. MB has been shown to be effective in inhibiting P...

    Authors: G. Lu, M. Nagbanshi, N. Goldau, M. Mendes Jorge, P. Meissner, A. Jahn, F. P. Mockenhaupt and O. Müller

    Citation: BMC Medicine 2018 16:59

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  23. Content type: Research article

    Poor adherence to either antiretroviral treatment (ART) or pre-exposure prophylaxis (PrEP) can promote drug resistance, though this risk is thought to be considerably higher for ART. In the population of men w...

    Authors: Mingwang Shen, Yanni Xiao, Libin Rong, Lauren Ancel Meyers and Steven E. Bellan

    Citation: BMC Medicine 2018 16:58

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  24. Content type: Research article

    Most previous research on migrant health in Europe has taken a cross-sectional perspective, without a specific focus on the older population. Having knowledge about inequalities in health transitions over the ...

    Authors: Matias Reus-Pons, Clara H. Mulder, Eva U. B. Kibele and Fanny Janssen

    Citation: BMC Medicine 2018 16:57

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  25. Content type: Research article

    Recently, a new algorithm for automatic computer certification of verbal autopsy data named InSilicoVA was published. The authors presented their algorithm as a statistical method and assessed its performance ...

    Authors: Abraham D. Flaxman, Jonathan C. Joseph, Christopher J. L. Murray, Ian Douglas Riley and Alan D. Lopez

    Citation: BMC Medicine 2018 16:56

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  26. Content type: Research article

    Ethnic minority service users with schizophrenia and schizoaffective disorders may experience inequalities in care. There have been no recent studies assessing access to evidence-based treatments for psychosis...

    Authors: Jayati Das-Munshi, Dinesh Bhugra and Mike J. Crawford

    Citation: BMC Medicine 2018 16:55

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  27. Content type: Research article

    Autonomic dysreflexia is a severe and potentially life-threatening condition in patients with spinal cord injury, as it can lead to myocardial ischemia, brain hemorrhage, or even death. Urodynamic investigatio...

    Authors: Matthias Walter, Stephanie C. Knüpfer, Jacquelyn J. Cragg, Lorenz Leitner, Marc P. Schneider, Ulrich Mehnert, Andrei V. Krassioukov, Martin Schubert, Armin Curt and Thomas M. Kessler

    Citation: BMC Medicine 2018 16:53

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  28. Content type: Research article

    Gold mines represent a potential hotspot for Mycobacterium tuberculosis (Mtb) transmission and may be exacerbating the tuberculosis (TB) epidemic in South Africa. However, the presence of multiple factors complic...

    Authors: Stewart T. Chang, Violet N. Chihota, Katherine L. Fielding, Alison D. Grant, Rein M. Houben, Richard G. White, Gavin J. Churchyard, Philip A. Eckhoff and Bradley G. Wagner

    Citation: BMC Medicine 2018 16:52

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  29. Content type: Correspondence

    Despite the gender parity existing in medical schools for over three decades, women remain underrepresented in academic medical centers, particularly in senior ranks and in leadership roles. This has consequen...

    Authors: Reena Pattani, Christine Marquez, Camellia Dinyarian, Malika Sharma, Julie Bain, Julia E. Moore and Sharon E. Straus

    Citation: BMC Medicine 2018 16:48

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  30. Content type: Research article

    While the heterogeniety of pain progression has been studied in chronic diseases, the extent to which patterns of pain progression among people in general as well as across different diseases affect social, ci...

    Authors: Richard J. E. James, David A. Walsh and Eamonn Ferguson

    Citation: BMC Medicine 2018 16:51

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  31. Content type: Research article

    Meat is an important source of high-quality protein and vitamin B but also has a relatively high content of saturated and trans fatty acids. Although protein and vitamin B intake seems to protect people from func...

    Authors: Ellen A. Struijk, José R. Banegas, Fernando Rodríguez-Artalejo and Esther Lopez-Garcia

    Citation: BMC Medicine 2018 16:50

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  32. Content type: Research article

    In November 2016, the Dutch Health Council recommended hepatitis B (HBV) screening for first-generation immigrants from HBV endemic countries. However, these communities show relatively low attendance rates fo...

    Authors: Nora Hamdiui, Mart L. Stein, Aura Timen, Danielle Timmermans, Albert Wong, Maria E. T. C. van den Muijsenbergh and Jim E. van Steenbergen

    Citation: BMC Medicine 2018 16:47

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  33. Content type: Research article

    Drug-induced liver injury (DILI) is a common complication of tuberculosis treatment. We utilised data from the REMoxTB clinical trial to describe the incidence of predisposing factors and the natural history i...

    Authors: Conor Duncan Tweed, Genevieve Helen Wills, Angela M. Crook, Rodney Dawson, Andreas H. Diacon, Cheryl E. Louw, Timothy D. McHugh, Carl Mendel, Sarah Meredith, Lerato Mohapi, Michael E. Murphy, Stephen Murray, Sara Murthy, Andrew J. Nunn, Patrick P. J. Phillips, Kasha Singh…

    Citation: BMC Medicine 2018 16:46

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  34. Content type: Research article

    The U.S. Food and Drug Administration (FDA) often approves new drugs based on trials that use surrogate markers for endpoints, which involve certain trade-offs and may risk making erroneous inferences about th...

    Authors: Joshua D. Wallach, Oriana Ciani, Alison M. Pease, Gregg S. Gonsalves, Harlan M. Krumholz, Rod S. Taylor and Joseph S. Ross

    Citation: BMC Medicine 2018 16:45

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  35. Content type: Research article

    Insufficient sleep duration and obstructive sleep apnea, two common causes of sleep deficiency in adults, can result in excessive sleepiness, a well-recognized cause of motor vehicle crashes, although their co...

    Authors: Daniel J. Gottlieb, Jeffrey M. Ellenbogen, Matt T. Bianchi and Charles A. Czeisler

    Citation: BMC Medicine 2018 16:44

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  36. Content type: Research article

    Refugees may have an increased vulnerability to infectious diseases, and the consequences of an outbreak are more severe in a refugee camp. When an outbreak is suspected, access to clinical information is crit...

    Authors: Amanda M. Rojek, Kassiani Gkolfinopoulou, Apostolos Veizis, Angeliki Lambrou, Lyndsey Castle, Theano Georgakopoulou, Karl Blanchet, Takis Panagiotopoulos and Peter W. Horby

    Citation: BMC Medicine 2018 16:43

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  37. Content type: Research article

    An inverse relationship between allergies with glioma risk has been reported in several but not all epidemiological observational studies. We performed an analysis of genetic variants associated with atopy to ...

    Authors: Linden Disney-Hogg, Alex J. Cornish, Amit Sud, Philip J. Law, Ben Kinnersley, Daniel I. Jacobs, Quinn T. Ostrom, Karim Labreche, Jeanette E. Eckel-Passow, Georgina N. Armstrong, Elizabeth B. Claus, Dora Il’yasova, Joellen Schildkraut, Jill S. Barnholtz-Sloan, Sara H. Olson, Jonine L. Bernstein…

    Citation: BMC Medicine 2018 16:42

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  38. Content type: Research article

    Clusterin, also known as apolipoprotein J (apoJ), is one of the most abundantly expressed apolipoproteins in the brain after apolipoprotein E (apoE). Like the ε4 allele of the apolipoprotein E gene (APOE), the cl...

    Authors: Liv Tybjærg Nordestgaard, Anne Tybjærg-Hansen, Katrine Laura Rasmussen, Børge G. Nordestgaard and Ruth Frikke-Schmidt

    Citation: BMC Medicine 2018 16:39

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  39. Content type: Research article

    Since 2015, Europe has been facing an unprecedented arrival of refugees and migrants: more than one million people entered via land and sea routes. During their travels, refugees and migrants often face harsh ...

    Authors: Jihane Ben Farhat, Karl Blanchet, Pia Juul Bjertrup, Apostolos Veizis, Clément Perrin, Rebecca M. Coulborn, Philippe Mayaud and Sandra Cohuet

    Citation: BMC Medicine 2018 16:40

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  40. Content type: Research article

    Marine resources including fatty fish are important sources of n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFAs), which are important for brain development. To our knowledge, this is the first randomiz...

    Authors: Jannike Øyen, Ingrid Kvestad, Lisa Kolden Midtbø, Ingvild Eide Graff, Mari Hysing, Kjell Morten Stormark, Maria Wik Markhus, Valborg Baste, Livar Frøyland, Berthold Koletzko, Hans Demmelmair, Lisbeth Dahl, Øyvind Lie and Marian Kjellevold

    Citation: BMC Medicine 2018 16:41

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  41. Content type: Research article

    Hyperlactataemia (HL) is a biomarker of disease severity that predicts mortality in patients with sepsis and malaria. Lactate clearance (LC) during resuscitation has been shown to be a prognostic factor of sur...

    Authors: A. Aramburo, Jim Todd, Elizabeth C. George, Sarah Kiguli, Peter Olupot-Olupot, Robert O. Opoka, Charles Engoru, Samuel O. Akech, Richard Nyeko, George Mtove, Diana M. Gibb, Abdel G. Babiker and Kathryn Maitland

    Citation: BMC Medicine 2018 16:37

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  42. Content type: Research article

    Antidepressants are one of the most commonly prescribed medications in young and middle-aged adults, but there is relatively little information on their safety across a range of adverse outcomes in this age gr...

    Authors: Carol Coupland, Trevor Hill, Richard Morriss, Michael Moore, Antony Arthur and Julia Hippisley-Cox

    Citation: BMC Medicine 2018 16:36

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  43. Content type: Research article

    Acute symptomatic seizures and febrile seizures are common in children admitted to hospitals in Africa and may be markers of brain dysfunction. They may be associated with behavioural and emotional problems, b...

    Authors: Symon M. Kariuki, Amina Abubakar, Martha Kombe, Michael Kazungu, Rachael Odhiambo, Alan Stein and Charles R. J. C. Newton

    Citation: BMC Medicine 2018 16:35

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  44. Content type: Correction

    The original article [1] contains a major error whereby all rates in Table 2 are mistakenly presented as 50% of their true values; this error was caused by a miscalculation in annualising the original values t...

    Authors: Matthew J. Spittal, David M. Studdert, Ron Paterson and Marie M. Bismark

    Citation: BMC Medicine 2018 16:38

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    The original article was published in BMC Medicine 2016 14:198

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