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  1. Ketone bodies (KBs) are an alternative energy supply for brain functions when glucose is limited. The most abundant ketone metabolite, 3-β-hydroxybutyrate (BOHBUT), has been suggested to prevent or delay cogni...

    Authors: Wichanon Sae-jie, Suangsuda Supasai, Mika Kivimaki, Jackie F. Price, Andrew Wong, Meena Kumari, Jorgen Engmann, Tina Shah, Amand F. Schmidt, Tom R. Gaunt, Aroon Hingorani and Pimphen Charoen
    Citation: BMC Medicine 2023 21:340
    Content type: Research article Published on:

  2. Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with a 5-year survival rate of 6% following a diagnosis, and novel therapeutic modalities are needed. Protease-activated receptor 1 (PAR1) is...

    Authors: Hao-Chien Hung, Ming-Huei Fan, Daniel Wang, Carol H. Miao, Pong Su and Chao-Lien Liu
    Citation: BMC Medicine 2023 21:338
    Content type: Research article Published on:

  3. Evidence on the role of exogenous female sex steroid hormones in asthma development in women remains conflicting. We sought to quantify the potential causal role of hormonal contraceptives and menopausal hormo...

    Authors: Guoqiang Zhang, Rani Basna, Maya B. Mathur, Cecilia Lässer, Roxana Mincheva, Linda Ekerljung, Göran Wennergren, Madeleine Rådinger, Bo Lundbäck, Hannu Kankaanranta and Bright I. Nwaru
    Citation: BMC Medicine 2023 21:337
    Content type: Research article Published on:

  5. Numerous studies over the past four decades have revealed that breast cancer screening (BCS) significantly reduces breast cancer (BC) mortality. However, in BRICS-plus countries, the association between BCS an...

    Authors: Sumaira Mubarik, Saima Shakil Malik, Zhang Yanran, Eelko Hak, Nawsherwan, Fang Wang and Chuanhua Yu
    Citation: BMC Medicine 2023 21:299
    Content type: Research article Published on:

  6. For decades, antenatal care in high-resource settings has involved 12–14 face-to-face visits across pregnancy. The COVID-19 pandemic forced many care providers to rapidly embrace telehealth to reduce face-to-f...

    Authors: Jessica Atkinson, Roxanne Hastie, Susan Walker, Anthea Lindquist and Stephen Tong
    Citation: BMC Medicine 2023 21:332
    Content type: Review Published on:

  7. In the United States, the tuberculosis (TB) disease burden and associated factors vary substantially across states. While public health agencies must choose how to deploy resources to combat TB and latent tube...

    Authors: Nicole A. Swartwood, Christian Testa, Ted Cohen, Suzanne M. Marks, Andrew N. Hill, Garrett Beeler Asay, Jennifer Cochran, Kevin Cranston, Liisa M. Randall, Andrew Tibbs, C. Robert Horsburgh Jr, Joshua A. Salomon and Nicolas A. Menzies
    Citation: BMC Medicine 2023 21:331
    Content type: Software Published on:

  8. Natural killer/T cell lymphoma (NKTCL) is an aggressive lymphoma with a poor prognosis. Chimeric antigen receptor-transduced T (CAR-T) cell therapy has become a promising immunotherapeutic strategy against hae...

    Authors: Hongwen Li, Wenting Song, Jiazhuo Wu, Zhuangzhuang Shi, Yuyang Gao, Jiwei Li, Lijuan Han, Jianxiang Zhang, Zhaoming Li, Yong Li and Mingzhi Zhang
    Citation: BMC Medicine 2023 21:330
    Content type: Research article Published on:

  9. Patients with acute pancreatitis (AP) exhibit specific phenotypes of gut microbiota associated with severity. Gut microbiota and host interact primarily through metabolites; regrettably, little is known about ...

    Authors: Qi Zhou, Xufeng Tao, Fangyue Guo, Yu Wu, Dawei Deng, Linlin Lv, Deshi Dong, Dong Shang and Hong Xiang
    Citation: BMC Medicine 2023 21:329
    Content type: Research article Published on:

  10. Deoxynivalenol (DON), one of the most prevalent mycotoxins, has been found to cause fetal growth retardation in animals. However, limited evidence exists regarding its effects on pregnant women.

    Authors: Tianqi Tan, Tingting Chen, Wenwen Zhu, Lin Gong, Yizhong Yan, Qian Li, Li Chen, Yiling Li, Jialin Liu, Yanan Li, Xuefeng Yang, Liping Hao, Huaiji Wang, Nianhong Yang and Sheng Wei
    Citation: BMC Medicine 2023 21:328
    Content type: Research article Published on:

  11. CD133 is considered a marker for cancer stem cells (CSCs) in several types of tumours, including hepatocellular carcinoma (HCC). Chimeric antigen receptor-specific T (CAR-T) cells targeting CD133-positive CSCs...

    Authors: Chaopin Yang, Jinqi You, Qiuzhong Pan, Yan Tang, Liming Cai, Yue Huang, Jiamei Gu, Yizhi Wang, Xinyi Yang, Yufei Du, Dijun Ouyang, Hao Chen, Haoran Zhong, Yongqiang Li, Jieying Yang, Yulong Han…
    Citation: BMC Medicine 2023 21:327
    Content type: Research article Published on:

  12. To eliminate cervical cancer as a public health problem, the World Health Organization had recommended routine vaccination of adolescent girls with two doses of the human papillomavirus (HPV) vaccine before se...

    Authors: Kiesha Prem, Yoon Hong Choi, Élodie Bénard, Emily A. Burger, Liza Hadley, Jean-François Laprise, Mary Caroline Regan, Mélanie Drolet, Stephen Sy, Kaja Abbas, Allison Portnoy, Jane J. Kim, Marc Brisson and Mark Jit
    Citation: BMC Medicine 2023 21:313
    Content type: Research article Published on:

    The Commentary to this article has been published in BMC Medicine 2023 21:387

  13. Moderate and late preterm (MLPT) birth accounts for the vast majority of preterm births, which is a global public health problem. The association between MLPT and neurobehavioral developmental delays in childr...

    Authors: Yumin Zhu, Yimin Zhang, Yunfan Jin, Heyue Jin, Kun Huang, Juan Tong, Hong Gan, Chen Rui, Jia Lv, Xianyan Wang, Qu’nan Wang and Fangbiao Tao
    Citation: BMC Medicine 2023 21:326
    Content type: Research article Published on:

  15. Chronic remote ischemic conditioning (CRIC) has been shown to improve myocardial ischemia in experimental animal studies; however, its effectiveness in patients with chronic stable angina (CSA) has not been in...

    Authors: Quan Guo, Zhenzhou Zhao, Fan Yang, Zhiwen Zhang, Xiaoyu Rao, Jing Cui, Qingbo Shi, Kaiyuan Liu, Kang Zhao, Haiyu Tang, Liang Peng, Cao Ma, Jun Pu and Muwei Li
    Citation: BMC Medicine 2023 21:324
    Content type: Research article Published on:

  16. Precocious puberty (PP) in girls is traditionally defined as the onset of breast development before the age of 8 years. The specific biomarkers of premature thelarche (PT) and central precocious puberty (CPP) ...

    Authors: Jinxia Wu, Jing Chen, Rong Huang, Hongwei Zhu, Lin Che, Yanyan Lin, Yajie Chang, Guiping Shen and Jianghua Feng
    Citation: BMC Medicine 2023 21:323
    Content type: Research article Published on:

  17. There is limited evidence to support the use of vestibular rehabilitation therapy (VRT) on improving balance and gait in patients after stroke. This systematic review aimed to evaluate the effects of VRT in ad...

    Authors: Lijiao Meng, Qiu Liang, Jianrong Yuan, Siyi Li, Yanlei Ge, Jingyi Yang, Raymond C C Tsang and Quan Wei
    Citation: BMC Medicine 2023 21:322
    Content type: Research article Published on:

  18. As we continue the fourth year of the COVID-19 epidemic, SARS-CoV-2 infections still cause high morbidity and mortality in the United States. During 2020–2022, COVID-19 was one of the leading causes of death i...

    Authors: Fuhan Yang, Thu Nguyen-Anh Tran, Emily Howerton, Maciej F. Boni and Joseph L. Servadio
    Citation: BMC Medicine 2023 21:321
    Content type: Research article Published on:

  19. Severe malaria in pregnancy causes maternal mortality, morbidity, and adverse foetal outcomes. The factors contributing to adverse maternal and foetal outcomes are not well defined. We aimed to identify the fa...

    Authors: Makoto Saito, Aung Pyae Phyo, Cindy Chu, Stephane Proux, Marcus J. Rijken, Candy Beau, Htun Htun Win, Laypaw Archasuksan, Jacher Wiladphaingern, Nguyen H. Phu, Tran T. Hien, Nick P. Day, Arjen M. Dondorp, Nicholas J. White, François Nosten and Rose McGready
    Citation: BMC Medicine 2023 21:320
    Content type: Research article Published on:

  20. Many countries have introduced reforms with the aim of primary care transformation (PCT). Common objectives include meeting service delivery challenges associated with ageing populations and health inequalitie...

    Authors: D. A. G Henderson, E Donaghy, M Dozier, B Guthrie, H Huang, M Pickersgill, E Stewart, A Thompson, H. H. X Wang and S. W Mercer
    Citation: BMC Medicine 2023 21:319
    Content type: Research article Published on:

  21. Prenatal alcohol exposure (PAE) is a worldwide public health concern. While PAE is known to be associated with low birth weight, little is known about timing and quantity of PAE on fetal growth. This study inv...

    Authors: Marin Pielage, Hanan El Marroun, Hein J. Odendaal, Sten P. Willemsen, Manon H. J. Hillegers, Eric A. P. Steegers and Melek Rousian
    Citation: BMC Medicine 2023 21:318
    Content type: Research article Published on:

  22. Maternal pre-pregnancy obesity is an established risk factor for childhood obesity. Investigating epigenetic alterations induced by maternal obesity during fetal development could gain mechanistic insight into...

    Authors: Jiahui Si, Anat Yaskolka Meir, Xiumei Hong, Guoying Wang, Wanyu Huang, Colleen Pearson, William G. Adams, Xiaobin Wang and Liming Liang
    Citation: BMC Medicine 2023 21:317
    Content type: Research article Published on:

  23. Micronutrients, namely vitamins and minerals, are associated with cancer outcomes; however, their reported effects have been inconsistent across studies. We aimed to identify the causally estimated effects of ...

    Authors: Jong Yeob Kim, Minku Song, Min Seo Kim, Pradeep Natarajan, Ron Do, Woojae Myung and Hong-Hee Won
    Citation: BMC Medicine 2023 21:316
    Content type: Research article Published on:

  24. Variated anti-cancer therapies are combined with immune checkpoint blockades (ICBs) for improving ICB therapeutic efficacy. Occurrence of tissue damage is common that triggers multiple inflammatory cytokine ge...

    Authors: Ruochan Zhang, Kun Chen, Caifeng Gong, Zhiyuan Wu, Chungui Xu, Xing-Ning Li, Fei Zhao, Dongmei Wang, Jianqiang Cai, Aiping Zhou and Chunfeng Qu
    Citation: BMC Medicine 2023 21:315
    Content type: Research article Published on:

  25. Heterogeneity in reported outcomes can limit the synthesis of research evidence. A core outcome set informs what outcomes are important and should be measured as a minimum in all future studies. We report the ...

    Authors: Siang Ing Lee, Stephanie Hanley, Zoe Vowles, Rachel Plachcinski, Ngawai Moss, Megha Singh, Chris Gale, Adeniyi Francis Fagbamigbe, Amaya Azcoaga-Lorenzo, Anuradhaa Subramanian, Beck Taylor, Catherine Nelson-Piercy, Christine Damase-Michel, Christopher Yau, Colin McCowan, Dermot O’Reilly…
    Citation: BMC Medicine 2023 21:314
    Content type: Research article Published on:

  26. All health overuse implies an unnecessary risk of patients suffering adverse events (AEs). However, this hypothesis has not been corroborated by direct estimates for inappropriate hospital admission (IHA). The...

    Authors: Diego San Jose-Saras, Jorge Vicente-Guijarro, Paulo Sousa, Paloma Moreno-Nunez and Jesús María Aranaz-Andres
    Citation: BMC Medicine 2023 21:312
    Content type: Research article Published on:

  28. Aging is a dynamic and heterogeneous process that may better be captured by trajectories of aging biomarkers. Biological age has been advocated as a better biomarker of aging than chronological age, and plant-...

    Authors: Sicong Wang, Wenyuan Li, Shu Li, Huakang Tu, Junlin Jia, Wenting Zhao, Andi Xu, Wenxin Xu, Min Kuang Tsai, David Ta-Wei Chu, Chi Pang Wen and Xifeng Wu
    Citation: BMC Medicine 2023 21:310
    Content type: Research article Published on:

  29. Measurement of multimorbidity in research is variable, including the choice of the data source used to ascertain conditions. We compared the estimated prevalence of multimorbidity and associations with mortali...

    Authors: Clare MacRae, Daniel Morales, Stewart W. Mercer, Nazir Lone, Andrew Lawson, Emily Jefferson, David McAllister, Marjan van den Akker, Alan Marshall, Sohan Seth, Anna Rawlings, Jane Lyons, Ronan A. Lyons, Amy Mizen, Eleojo Abubakar, Chris Dibben…
    Citation: BMC Medicine 2023 21:309
    Content type: Research article Published on:

  31. Diet is increasingly recognized as an important risk factor for mental health. However, evidence regarding the association between diet pattern and depressive and anxiety symptoms is limited. We aimed to inves...

    Authors: Han Chen, Zhi Cao, Yabing Hou, Hongxi Yang, Xiaohe Wang and Chenjie Xu
    Citation: BMC Medicine 2023 21:307
    Content type: Research article Published on:

  32. There is increasing interest in the use of liquid biopsies, but data on longitudinal analyses of circulating tumor DNA (ctDNA) remain relatively limited. Here, we report a longitudinal ctDNA analysis of MONALE...

    Authors: Joanne Chiu, Fei Su, Mukta Joshi, Norikazu Masuda, Takashi Ishikawa, Tomoyuki Aruga, Juan Pablo Zarate, Naveen Babbar, O. Alejandro Balbin and Yoon-Sim Yap
    Citation: BMC Medicine 2023 21:306
    Content type: Research article Published on:

  33. Patients with multimorbidity are frequent users of healthcare, but fragmented care may lead to suboptimal treatment. Yet, this has never been examined across healthcare sectors on a national scale. We aimed to...

    Authors: Anders Prior, Claus Høstrup Vestergaard, Peter Vedsted, Susan M. Smith, Line Flytkjær Virgilsen, Linda Aagaard Rasmussen and Morten Fenger-Grøn
    Citation: BMC Medicine 2023 21:305
    Content type: Research article Published on:

  34. Diabetic retinopathy (DR) is a major sight-threatening microvascular complication in individuals with diabetes. Systemic inflammation combined with oxidative stress is thought to capture most of the complexiti...

    Authors: Aravind Lathika Rajendrakumar, Simona M. Hapca, Anand Thakarakkattil Narayanan Nair, Yu Huang, Mehul Kumar Chourasia, Ryan Shun-Yuen Kwan, Charvi Nangia, Moneeza K. Siddiqui, Prathiba Vijayaraghavan, Shona Z. Matthew, Graham P. Leese, Viswanathan Mohan, Ewan R. Pearson, Alexander S. F. Doney and Colin N. A. Palmer
    Citation: BMC Medicine 2023 21:304
    Content type: Research article Published on:

  35. Children and young people’s (CYP) mental health is worsening, and an increasing number are seeking psychiatric and mental health care. Whilst many CYPs with low-to-medium levels of psychiatric distress can be ...

    Authors: Eleanor Keiller, Saba Masood, Ben Hoi-ching Wong, Cerian Avent, Kofi Bediako, Rebecca Margaret Bird, Isabel Boege, Marta Casanovas, Veronika Beatrice Dobler, Maya James, Jane Kiernan, Maria Martinez-Herves, Thinh Vinh Thanh Ngo, Ana Pascual-Sanchez, Izabela Pilecka, Paul L Plener…
    Citation: BMC Medicine 2023 21:303
    Content type: Guideline Published on:

  36. The results of human observational studies on the correlation between gut microbiota perturbations and polycystic ovary syndrome (PCOS) have been contradictory. This study aimed to perform the first systematic...

    Authors: Pan Li, Ping Shuai, Sj Shen, Huimin Zheng, Ping Sun, Renfang Zhang, Shanwei Lan, Zixin Lan, Thisun Jayawardana, Yumei Yang, Jianhui Zhao, Yuping Liu, Xia Chen, Emad M. El-Omar and Zhengwei Wan
    Citation: BMC Medicine 2023 21:302
    Content type: Research article Published on:

  37. We recently published an article in BMC Medicine looking at the potential health and economic impact of paediatric vaccination using next-generation influenza vaccines in Kenya: a modelling study. In their commen...

    Authors: Naomi R. Waterlow, Simon R. Procter, Rosalind M. Eggo and Mark Jit
    Citation: BMC Medicine 2023 21:301
    Content type: Correspondence Published on:

    The original article was published in BMC Medicine 2023 21:273

    The Research article to this article has been published in BMC Medicine 2023 21:106

  38. Patients with human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer and primary resistance to trastuzumab have a poor clinical outcome and lack good evidence to inform clinical decisi...

    Authors: Jun Cao, Yuee Teng, Huiping Li, Lili Zhang, Quchang Ouyang, Weimin Xie, Yueyin Pan, Zhenchuan Song, Xiaoling Ling, Xiaohong Wu, Jingwei Xu, Li Li, Liping Ren, Hong Wang, Dongxian Zhou, Jing Luo…
    Citation: BMC Medicine 2023 21:300
    Content type: Research article Published on:

  39. Tuberous sclerosis complex (TSC) is a rare and complex genetic disorder, associated with tumor growth in various organ systems, epilepsy, and a range of neuropsychiatric manifestations including intellectual d...

    Authors: Annelieke R. Müller, Michiel A. J. Luijten, Lotte Haverman, Wendela L. de Ranitz-Greven, Peter Janssens, André B. Rietman, Leontine W. ten Hoopen, Laura C. G. de Graaff, Marie-Claire de Wit, Anna C. Jansen, Tanjala Gipson, Jamie K. Capal, Petrus J. de Vries and Agnies M. van Eeghen
    Citation: BMC Medicine 2023 21:298
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Medicine 2023 21:401

  40. The relationship between adverse childhood experiences (ACEs) and adverse adulthood experiences (AAEs) and their association with incident cardiovascular disease (CVD) have not been extensively studied. Consid...

    Authors: Wanxin Wang, Yifeng Liu, Yuwei Yang, Weiqing Jiang, Yanyan Ni, Xue Han, Ciyong Lu and Lan Guo
    Citation: BMC Medicine 2023 21:297
    Content type: Research article Published on:

  41. Caffeine exposure modifies the turnover of monoamine neurotransmitters, which play a role in several neuropsychiatric disorders. We conducted a Mendelian randomization study to investigate whether higher plasm...

    Authors: Benjamin Woolf, Héléne T. Cronjé, Loukas Zagkos, Stephen Burgess, Dipender Gill and Susanna C. Larsson
    Citation: BMC Medicine 2023 21:296
    Content type: Research article Published on:

  43. Cholangiocarcinoma (CCA) is a highly aggressive malignant tumor, and its diagnosis is still a challenge. This study aimed to identify a novel bile marker for CCA diagnosis based on proteomics and establish a d...

    Authors: Long Gao, Yanyan Lin, Ping Yue, Shuyan Li, Yong Zhang, Ningning Mi, Mingzhen Bai, Wenkang Fu, Zhili Xia, Ningzu Jiang, Jie Cao, Man Yang, Yanni Ma, Fanxiang Zhang, Chao Zhang, Joseph W. Leung…
    Citation: BMC Medicine 2023 21:294
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Medicine 2023 21:368

  44. Exercise training is beneficial in enhancing physical function and quality of life in cancer patients. Its comprehensive implementation remains challenging, and underlying cardiopulmonary adaptations are poorl...

    Authors: Roberto Falz, Christian Bischoff, René Thieme, Uwe Tegtbur, Peter Hillemanns, Jens-Uwe Stolzenburg, Bahriye Aktas, Ulrich Bork, Jürgen Weitz, Johannes Lässing, Christian Leps, Johannes Voß, Florian Lordick, Antina Schulze, Ines Gockel and Martin Busse
    Citation: BMC Medicine 2023 21:293
    Content type: Research article Published on:

  45. Folic acid (FA) supplementation is associated with a lower risk of the neural tube and heart defects and is recommended for women of childbearing age. Although there are detailed recommendations, differences i...

    Authors: Jing Dong, Lin-Liang Yin, Xue-Dong Deng, Chun-Ya Ji, Qi Pan, Zhong Yang, Ting Peng and Jiang-Nan Wu
    Citation: BMC Medicine 2023 21:292
    Content type: Research article Published on:

  46. Comorbidity is the rule rather than the exception for childhood and adolescent onset mental disorders, but we cannot predict its occurrence and do not know the neural mechanisms underlying comorbidity. We inve...

    Authors: Nanyu Kuang, Zhaowen Liu, Gechang Yu, Xinran Wu, Benjamin Becker, Huaxin Fan, Songjun Peng, Kai Zhang, Jiajia Zhao, Jujiao Kang, Guiying Dong, Xingming Zhao, Barbara J. Sahakian, Trevor W. Robbins, Wei Cheng, Jianfeng Feng…
    Citation: BMC Medicine 2023 21:291
    Content type: Research article Published on:

  48. India had an estimated 2.9 million tuberculosis cases and 506 thousand deaths in 2021. Novel vaccines effective in adolescents and adults could reduce this burden. M72/AS01E and BCG-revaccination have recently co...

    Authors: Rebecca A. Clark, Chathika K. Weerasuriya, Allison Portnoy, Christinah Mukandavire, Matthew Quaife, Roel Bakker, Danny Scarponi, Rebecca C. Harris, Kirankumar Rade, Sanjay Kumar Mattoo, Dheeraj Tumu, Nicolas A. Menzies and Richard G. White
    Citation: BMC Medicine 2023 21:288
    Content type: Research article Published on:

  49. Disrupted intestinal epithelial barrier is one of the major causes of Crohn’s disease (CD). Novel molecular targets for intestinal epithelial barrier are essential to treatment of CD. Transmembrane and immunog...

    Authors: Longyuan Zhou, Liguo Zhu, Xiaomin Wu, Shixian Hu, Shenghong Zhang, Min Ning, Jun Yu and Minhu Chen
    Citation: BMC Medicine 2023 21:287
    Content type: Research article Published on:

  50. Microglia are known to regulate stress and anxiety in both humans and animal models. Psychosocial stress is the most common risk factor for the development of schizophrenia. However, how microglia/brain macrop...

    Authors: Ling Yan, Yanli Li, Fengmei Fan, Mengzhuang Gou, Fangling Xuan, Wei Feng, Keerthana Chithanathan, Wei Li, Junchao Huang, Hongna Li, Wenjin Chen, Baopeng Tian, Zhiren Wang, Shuping Tan, Alexander Zharkovsky, L. Elliot Hong…
    Citation: BMC Medicine 2023 21:286
    Content type: Research article Published on:
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