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  1. The past decade has seen considerable interest in the development and evaluation of complex interventions to improve health. Such interventions can only have a significant impact on health and health care if t...

    Authors: Elizabeth Murray, Shaun Treweek, Catherine Pope, Anne MacFarlane, Luciana Ballini, Christopher Dowrick, Tracy Finch, Anne Kennedy, Frances Mair, Catherine O'Donnell, Bie Nio Ong, Tim Rapley, Anne Rogers and Carl May
    Citation: BMC Medicine 2010 8:63
  2. The objectives of this research were (a) to describe the current status of grant review for biomedical projects and programmes from the perspectives of international funding organisations and grant reviewers, ...

    Authors: Sara Schroter, Trish Groves and Liselotte Højgaard
    Citation: BMC Medicine 2010 8:62
  3. Internet addiction, while not yet officially codified within a psychopathological framework, is growing both in prevalence and within the public consciousness as a potentially problematic condition with many p...

    Authors: Dimitri A Christakis
    Citation: BMC Medicine 2010 8:61
  4. Exercise-based therapy is known to enhance motor recovery after stroke but the most appropriate amount, i.e. the dose, of therapy is unknown. To determine the strength of current evidence for provision of a hi...

    Authors: Emma V Cooke, Kathryn Mares, Allan Clark, Raymond C Tallis and Valerie M Pomeroy
    Citation: BMC Medicine 2010 8:60
  5. The Internet is used increasingly by providers as a tool for disseminating pain-related health information and by patients as a resource about health conditions and treatment options. However, health informati...

    Authors: Jatin Kaicker, Victoria Borg Debono, Wilfred Dang, Norman Buckley and Lehana Thabane
    Citation: BMC Medicine 2010 8:59
  6. Herpes zoster (HZ) is a common disease, characterized by rash-associated localized pain. Its main complication, post-herpetic neuralgia (PHN), is difficult to treat and may last for months to years in the wake...

    Authors: Giustino Parruti, Monica Tontodonati, Cristina Rebuzzi, Ennio Polilli, Federica Sozio, Augusta Consorte, Adriana Agostinone, Francesco Di Masi, Gabriele Congedo, Domenico D'Antonio, Carla Granchelli, Claudio D'Amario, Carlo Carunchio, Lucio Pippa, Lamberto Manzoli and Antonio Volpi
    Citation: BMC Medicine 2010 8:58
  7. Decision making is a complex process and it is particularly challenging to make decisions with, or for, patients who are near the end of their life. Some of those challenges will not be resolved - due to our h...

    Authors: Linda Emanuel and Karen Glasser Scandrett
    Citation: BMC Medicine 2010 8:57
  8. Although the assessment of cardiovascular risk in individual patients takes into account a range of risk factors, the diagnosis and management of hypertension (high blood pressure) is largely determined by a s...

    Authors: Paul L Padfield
    Citation: BMC Medicine 2010 8:55
  9. Plant-based diets rich in fruit and vegetables can prevent development of several chronic age-related diseases. However, the mechanisms behind this protective effect are not elucidated. We have tested the hypo...

    Authors: Siv K Bøhn, Mari C Myhrstad, Magne Thoresen, Marit Holden, Anette Karlsen, Siv Haugen Tunheim, Iris Erlund, Mette Svendsen, Ingebjørg Seljeflot, Jan Ø Moskaug, Asim K Duttaroy, Petter Laake, Harald Arnesen, Serena Tonstad, Andrew Collins, Christan A Drevon…
    Citation: BMC Medicine 2010 8:54
  10. Peripheral intravenous device (IVD) complications were traditionally thought to be reduced by limiting dwell time. Current recommendations are to resite IVDs by 96 hours with the exception of children and pati...

    Authors: Claire M Rickard, Damhnat McCann, Jane Munnings and Matthew R McGrail
    Citation: BMC Medicine 2010 8:53
  11. Current 2005 guidelines for advanced cardiac life support strongly recommend immediate defibrillation for out-of-hospital cardiac arrest. However, findings from experimental and clinical studies have indicated...

    Authors: Pascal Meier, Paul Baker, Daniel Jost, Ian Jacobs, Bettina Henzi, Guido Knapp and Comilla Sasson
    Citation: BMC Medicine 2010 8:52
  12. Melatonin is extensively used in the USA in a non-regulated manner for sleep disorders. Prolonged release melatonin (PRM) is licensed in Europe and other countries for the short term treatment of primary insom...

    Authors: Alan G Wade, Ian Ford, Gordon Crawford, Alex McConnachie, Tali Nir, Moshe Laudon and Nava Zisapel
    Citation: BMC Medicine 2010 8:51
  13. Exercise is widely recommended to reduce osteoporosis, falls and related fragility fractures, but its effect on whole bone strength has remained inconclusive. The primary purpose of this systematic review and ...

    Authors: Riku Nikander, Harri Sievänen, Ari Heinonen, Robin M Daly, Kirsti Uusi-Rasi and Pekka Kannus
    Citation: BMC Medicine 2010 8:47
  14. Up to 90% of pregnant women experience nausea and vomiting. When prolonged or severe, this is known as hyperemesis gravidarum (HG), which can, in individual cases, be life threatening. In this article the aeti...

    Authors: JK Jueckstock, R Kaestner and I Mylonas
    Citation: BMC Medicine 2010 8:46
  15. Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional regulator of genes regulating oxygen homeostasis. The HIF-1 protein is composed of two HIF-1α and HIF-1β/aryl hydrocarbon receptor nuclear translo...

    Authors: Jean-Philippe Dales, Nathalie Beaufils, Monique Silvy, Christophe Picard, Vanessa Pauly, Vincent Pradel, Christine Formisano-Tréziny, Pascal Bonnier, Sophie Giusiano, Colette Charpin and Jean Gabert
    Citation: BMC Medicine 2010 8:44
  16. Neonatal hypothermia is associated with an increased mortality risk for 28 days. There are few community-based data on specific risk factors for neonatal hypothermia. Estimates of association between neonatal ...

    Authors: Luke C Mullany, Joanne Katz, Subarna K Khatry, Steven C LeClerq, Gary L Darmstadt and James M Tielsch
    Citation: BMC Medicine 2010 8:43
  17. Polycystic ovary syndrome (PCOS) is of clinical and public health importance as it is very common, affecting up to one in five women of reproductive age. It has significant and diverse clinical implications in...

    Authors: H Teede, A Deeks and L Moran
    Citation: BMC Medicine 2010 8:41
  18. Treatment of women for high-grade cervical cancer precursors frequently results in clearance of the associated high-risk human papillomavirus (hrHPV) infection but the role of treatment among women without hrH...

    Authors: Sylvia Taylor, Chunhui Wang, Thomas C Wright, Lynette Denny, Wei-Yann Tsai and Louise Kuhn
    Citation: BMC Medicine 2010 8:40
  19. Dark chocolate and flavanol-rich cocoa products have attracted interest as an alternative treatment option for hypertension, a known risk factor for cardiovascular disease. Previous meta-analyses concluded tha...

    Authors: Karin Ried, Thomas Sullivan, Peter Fakler, Oliver R Frank and Nigel P Stocks
    Citation: BMC Medicine 2010 8:39
  20. Psychological therapies provided in primary care are usually briefer than in secondary care. There has been no recent comprehensive review comparing their effectiveness for common mental health problems. We ai...

    Authors: John Cape, Craig Whittington, Marta Buszewicz, Paul Wallace and Lisa Underwood
    Citation: BMC Medicine 2010 8:38
  21. The potentially serious nature of herpes zoster (HZ) and the long-term complication post-herpetic neuralgia (PHN) are often underestimated. One in four people will contract herpes zoster in their lifetime, wit...

    Authors: Robert W Johnson, Didier Bouhassira, George Kassianos, Alain Leplège, Kenneth E Schmader and Thomas Weinke
    Citation: BMC Medicine 2010 8:37
  22. In a recently published paper, Harvey and Wessely put forward a 'biopsychosocial' explanatory model for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), which is proposed to be applicable to (chron...

    Authors: Michael Maes and Frank NM Twisk
    Citation: BMC Medicine 2010 8:35
  23. Myocardial infarction causes significant mortality and morbidity. Timely diagnosis allows clinicians to risk stratify their patients and select appropriate treatment. Biomarkers have been used to assist with t...

    Authors: Daniel Chan and Leong L Ng
    Citation: BMC Medicine 2010 8:34
  24. In both Europe and the US, resident physician work hour reduction has been a source of controversy within academic medicine. In 2008, the Institute of Medicine (IOM) recommended a reduction in resident physici...

    Authors: Alexander B Blum, Farbod Raiszadeh, Sandra Shea, David Mermin, Peter Lurie, Christopher P Landrigan and Charles A Czeisler
    Citation: BMC Medicine 2010 8:33
  25. The frequency of mental illness amongst adolescents and its potential long-term consequences make it an important topic to research in relation to risk and protective factors. Research on the relationship betw...

    Authors: Catherine Rothon, Phil Edwards, Kamaldeep Bhui, Russell M Viner, Stephanie Taylor and Stephen A Stansfeld
    Citation: BMC Medicine 2010 8:32
  26. Uncomplicated lower urinary tract infections (UTI) are usually treated with antibiotics. However, there is little evidence for alternative therapeutic options.

    Authors: Jutta Bleidorn, Ildikó Gágyor, Michael M Kochen, Karl Wegscheider and Eva Hummers-Pradier
    Citation: BMC Medicine 2010 8:30
  27. Forced expiratory volume in one second (FEV1) is used to diagnose and establish a prognosis in chronic obstructive pulmonary disease (COPD). Using multi-dimensional scores improves this predictive capacity.Two in...

    Authors: Cristóbal Esteban, José M Quintana, Javier Moraza, Myriam Aburto, Urko Aguirre, José I Aguirregomoscorta, Susana Aizpiri, Luis V Basualdo and Alberto Capelastegui
    Citation: BMC Medicine 2010 8:28
  28. Breast cancer studies frequently focus on the role of the tumor microenvironment in the promotion of cancer; however, the influence of the normal breast microenvironment on cancer cells remains relatively unkn...

    Authors: Jodie M Fleming, Tyler C Miller, Mariam Quinones, Zhen Xiao, Xia Xu, Matthew J Meyer, Erika Ginsburg, Timothy D Veenstra and Barbara K Vonderhaar
    Citation: BMC Medicine 2010 8:27
  29. Oncogenic point mutations in KIT or PDGFRA are recognized as the primary events responsible for the pathogenesis of most gastrointestinal stromal tumors (GIST), but additional genomic alterations are frequent and...

    Authors: Mara Silva, Isabel Veiga, Franclim R Ribeiro, Joana Vieira, Carla Pinto, Manuela Pinheiro, Bárbara Mesquita, Catarina Santos, Marta Soares, José Dinis, Lúcio Santos, Paula Lopes, Mariana Afonso, Carlos Lopes and Manuel R Teixeira
    Citation: BMC Medicine 2010 8:26
  30. Radiation therapy has come a long way from treatment planning based on orthogonal radiographs with large margins around tumours. Advances in imaging and radiation planning software have led to three-dimensiona...

    Authors: SA Bhide and CM Nutting
    Citation: BMC Medicine 2010 8:25
  31. Although current electronic methods of scientific publishing offer increased opportunities for publishing all research studies and describing them in sufficient detail, health research literature still suffers...

    Authors: Iveta Simera, David Moher, Allison Hirst, John Hoey, Kenneth F Schulz and Douglas G Altman
    Citation: BMC Medicine 2010 8:24
  32. There are few studies that have investigated temporal trends in risk of recurrent stroke. The aim of this study was to examine temporal trends in hospitalisation for stroke recurrence following incident hospit...

    Authors: James Lewsey, Pardeep S Jhund, Michelle Gillies, Jim WT Chalmers, Adam Redpath, Andrew Briggs, Matthew Walters, Peter Langhorne, Simon Capewell, John JV McMurray and Kate MacIntyre
    Citation: BMC Medicine 2010 8:23
  33. A central element in the current debate about best practice management of non-specific low back pain (NSLBP) is the efficacy of targeted versus generic (non-targeted) treatment. Many clinicians and researchers...

    Authors: Peter Kent, Hanne L Mjøsund and Ditte HD Petersen
    Citation: BMC Medicine 2010 8:22
  34. Appropriate choice and use of prognostic models in clinical practice require the use of good methods for both model development, and for developing prognostic indices and risk groups from the models. In order ...

    Authors: Susan Mallett, Patrick Royston, Rachel Waters, Susan Dutton and Douglas G Altman
    Citation: BMC Medicine 2010 8:21
  35. Amifostine (WR-2721, delivered as Ethyol®) is a phosphorylated aminothiol compound clinically used in addition to cis-platinum to reduce the toxic side effects of therapeutic treatment on normal cells without red...

    Authors: S Dedieu, X Canron, HR Rezvani, M Bouchecareilh, F Mazurier, R Sinisi, M Zanda, M Moenner, A Bikfalvi and S North
    Citation: BMC Medicine 2010 8:19
  36. Acute seizures are common among children admitted to hospitals in resource poor countries. However, there is little data on the burden, causes and outcome of neonatal seizures in sub-Saharan Africa. We determi...

    Authors: Michael Mwaniki, Ali Mathenge, Samson Gwer, Neema Mturi, Evasius Bauni, Charles RJC Newton, James Berkley and Richard Idro
    Citation: BMC Medicine 2010 8:16
  37. The use of placebo interventions outside clinical trials is ethically, professionally and legally controversial. Little is known about the frequency and circumstances of placebo use in clinical practice. Our a...

    Authors: Margrit Fässler, Karin Meissner, Antonius Schneider and Klaus Linde
    Citation: BMC Medicine 2010 8:15
  38. Melanoma incidence is on the rise and advanced melanoma carries an extremely poor prognosis. Treatment options, including chemotherapy and immunotherapy, are limited and offer low response rates and transient ...

    Authors: Yixiang Wang, Soroosh Radfar, Suhu Liu, Adam I Riker and Hung T Khong
    Citation: BMC Medicine 2010 8:14