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  1. Considerable controversy exists regarding the association between dietary calcium intake and risk of mortality from cardiovascular disease and all causes. Therefore, we performed a meta-analysis of prospective...

    Authors: Xia Wang, Hongxia Chen, Yingying Ouyang, Jun Liu, Gang Zhao, Wei Bao and Maosheng Yan
    Citation: BMC Medicine 2014 12:158
  2. Policy decisions about opt-in and opt-out consent for organ donation are based on limited evidence. To fill this gap we investigated the difference between deceased and living organ donation rates in opt-in an...

    Authors: Lee Shepherd, Ronan E O’Carroll and Eamonn Ferguson
    Citation: BMC Medicine 2014 12:131
  3. Pre-eclampsia is a common pregnancy related condition, which contributes significantly both to maternal and perinatal morbidity and mortality. The precise pathophysiology of pre-eclampsia is uncertain, and the...

    Authors: Jodie M Dodd, Cecelia O’Brien and Rosalie M Grivell
    Citation: BMC Medicine 2014 12:176
  4. Dietary factors have been suggested to play a role in the prevention of hypertensive disorders of pregnancy (HDP), including gestational hypertension and pre-eclampsia, but inconsistent findings have been repo...

    Authors: Danielle AJM Schoenaker, Sabita S Soedamah-Muthu and Gita D Mishra
    Citation: BMC Medicine 2014 12:157
  5. Considerable controversy exists regarding the relation between maternal caffeine intake during pregnancy and risk of low birth weight (birth weight <2,500 g). We aim to assess this association using a systemat...

    Authors: Ling-Wei Chen, Yi Wu, Nithya Neelakantan, Mary Foong-Fong Chong, An Pan and Rob M van Dam
    Citation: BMC Medicine 2014 12:174
  6. Liver cirrhosis is a major yet largely preventable and underappreciated cause of global health loss. Variations in cirrhosis mortality at the country level reflect differences in prevalence of risk factors suc...

    Authors: Ali A Mokdad, Alan D Lopez, Saied Shahraz, Rafael Lozano, Ali H Mokdad, Jeff Stanaway, Christopher JL Murray and Mohsen Naghavi
    Citation: BMC Medicine 2014 12:145
  7. Most of newly discovered cancer biomarkers fail in the clinic because they lack sensitivity and/or specificity. The current explosion in knowledge of the mutational spectrum of many cancer types, as a result o...

    Authors: Eleftherios P Diamandis
    Citation: BMC Medicine 2014 12:156
  8. Several non-invasive prediction scores for non-alcoholic fatty liver disease (NAFLD) have been developed, but their performance has not been compared and validated in the same population, and whether these pre...

    Authors: Ching-Lung Cheung, Karen SL Lam, Ian CK Wong and Bernard MY Cheung
    Citation: BMC Medicine 2014 12:154
  9. Identifying Plasmodium vivax antigen-specific antibodies associated with P. vivax infection and protective immunity is key to the development of serosurveillance tools and vaccines for malaria. Antibody targets o...

    Authors: Julia C Cutts, Rosanna Powell, Paul A Agius, James G Beeson, Julie A Simpson and Freya J I Fowkes
    Citation: BMC Medicine 2014 12:150
  10. Dengue is emerging as one of the most abundant vector-borne disease globally. Although the majority of infections are asymptomatic or result in only a brief systemic viral illness, a small proportion of patien...

    Authors: Sophie Yacoub and Bridget Wills
    Citation: BMC Medicine 2014 12:147
  11. Do-Not-Resuscitate (DNR) patients tend to receive less medical care after the order is written. To provide a clearer approach, the Ohio Department of Health adopted the Do-Not-Resuscitate law in 1998, indicati...

    Authors: Yen-Yuan Chen, Nahida H Gordon, Alfred F Connors, Allan Garland, Shan-Chwen Chang and Stuart J Youngner
    Citation: BMC Medicine 2014 12:146
  12. A link between measles virus and Crohn’s disease (CD) has been postulated. We assessed through bioinformatic and immunological approaches whether measles is implicated in CD induction, through molecular mimicry.

    Authors: Dimitrios Polymeros, Zacharias P Tsiamoulos, Andreas L Koutsoumpas, Daniel S Smyk, Maria G Mytilinaiou, Konstantinos Triantafyllou, Dimitrios P Bogdanos and Spiros D Ladas
    Citation: BMC Medicine 2014 12:139
  13. Obesity and metabolic syndrome are healthcare problems that continue to rise in frequency worldwide. Both phenotypes are a strong predictor for development of liver steatosis in the context of non-alcoholic fa...

    Authors: Bark Betzel and Joost PH Drenth
    Citation: BMC Medicine 2014 12:152
  14. Non-alcoholic fatty liver disease (NAFLD) is caused by abnormal accumulation of lipids within liver cells. Its prevalence is increasing in developed countries in association with obesity, and it represents a r...

    Authors: Raúl Jiménez-Agüero, José I Emparanza, Adolfo Beguiristain, Luis Bujanda, José M Alustiza, Elisabeth García, Elizabeth Hijona, Lander Gallego, Javier Sánchez-González, María J Perugorria, José I Asensio, Santiago Larburu, Maddi Garmendia, Mikel Larzabal, María P Portillo, Leixuri Aguirre…
    Citation: BMC Medicine 2014 12:137
  15. Although obesity and diabetes commonly co-exist, the evidence base to support obesity as the major driver of type 2 diabetes mellitus (T2DM), and the mechanisms by which this occurs, are now better appreciated.

    Authors: Naveed Sattar and Jason MR Gill
    Citation: BMC Medicine 2014 12:123
  16. Much research is underway on the links between diet and obesity. So too are long-running disputes among nutritionists on core questions about the relationship. This editorial reviews the state-of-play on four ...

    Authors: Jack Winkler
    Citation: BMC Medicine 2014 12:114
  17. Adherence to combination antiretroviral therapy (ART) is a key predictor of the success of human immunodeficiency virus (HIV) treatment, and is potentially amenable to intervention. Insight into predictors or ...

    Authors: Nienke Langebeek, Elizabeth H Gisolf, Peter Reiss, Sigrid C Vervoort, Thóra B Hafsteinsdóttir, Clemens Richter, Mirjam AG Sprangers and Pythia T Nieuwkerk
    Citation: BMC Medicine 2014 12:142
  18. The impact of mental disorders among homeless people is likely to be substantial in low income countries because of underdeveloped social welfare and health systems. As a first step towards advocacy and provis...

    Authors: Abebaw Fekadu, Charlotte Hanlon, Emebet Gebre-Eyesus, Melkamu Agedew, Haddis Solomon, Solomon Teferra, Tsehaysina Gebre-Eyesus, Yonas Baheretibeb, Girmay Medhin, Teshome Shibre, Abraham Workneh, Teketel Tegegn, Alehegn Ketema, Philip Timms, Graham Thornicroft and Martin Prince
    Citation: BMC Medicine 2014 12:138
  19. Text recycling, also referred to as self-plagiarism, is the reproduction of an author’s own text from a previous publication in a new publication. Opinions on the acceptability of this practice vary, with some...

    Authors: Stephanie Harriman and Jigisha Patel
    Citation: BMC Medicine 2014 12:148
  20. Environmental enteric dysfunction (EED) is an acquired syndrome of impaired gastrointestinal mucosal barrier function that is thought to play a key role in the pathogenesis of stunting in early life. It has be...

    Authors: Kelsey DJ Jones, Barbara Hünten-Kirsch, Ahmed MR Laving, Caroline W Munyi, Moses Ngari, Jenifer Mikusa, Musa M Mulongo, Dennis Odera, H Samira Nassir, Molline Timbwa, Moses Owino, Greg Fegan, Simon H Murch, Peter B Sullivan, John O Warner and James A Berkley
    Citation: BMC Medicine 2014 12:133
  21. Next generation sequencing (NGS) coupled with sophisticated bioinformatics tools yields an unprecedented amount of information regarding tumor genetics, with the potential to reveal insights into tumor behavio...

    Authors: Debu Tripathy, Kathleen Harnden, Kimberly Blackwell and Mark Robson
    Citation: BMC Medicine 2014 12:140
  22. Chronic stress is considered to be one of many causes of human preterm birth (PTB), but no direct evidence has yet been provided. Here we show in rats that stress across generations has downstream effects on e...

    Authors: Youli Yao, Alexandra M Robinson, Fabiola CR Zucchi, Jerrah C Robbins, Olena Babenko, Olga Kovalchuk, Igor Kovalchuk, David M Olson and Gerlinde AS Metz
    Citation: BMC Medicine 2014 12:121
  23. Human infections with avian influenza A(H7N9) virus are associated with severe illness and high mortality. To better inform triage decisions of hospitalization and management, we developed a clinical predictio...

    Authors: Qiaohong Liao, Dennis K M Ip, Tim K Tsang, Bin Cao, Hui Jiang, Fengfeng Liu, Jiandong Zheng, Zhibin Peng, Peng Wu, Yang Huai, Eric H Y Lau, Luzhao Feng, Gabriel M Leung, Hongjie Yu and Benjamin J Cowling
    Citation: BMC Medicine 2014 12:127
  24. With escalating health expenditure and a shrinking purse, there is increased focus on the cost efficacy of still patented versus generic medications in general, and for atypical antipsychotics in particular. I...

    Authors: Ajeet B Singh, Andrew A Nierenberg, Lakshmi N Yatham and Michael Berk
    Citation: BMC Medicine 2014 12:126
  25. Intimate partner violence (IPV) and HIV are important and interconnected public health concerns. While it is recognized that they share common social drivers, there is limited evidence surrounding the potentia...

    Authors: Tanya Abramsky, Karen Devries, Ligia Kiss, Janet Nakuti, Nambusi Kyegombe, Elizabeth Starmann, Bonnie Cundill, Leilani Francisco, Dan Kaye, Tina Musuya, Lori Michau and Charlotte Watts
    Citation: BMC Medicine 2014 12:122
  26. The epidemics of HIV and hypertension are converging in sub-Saharan Africa. Due to antiretroviral therapy (ART), more HIV-infected adults are living longer and gaining weight, putting them at greater risk for ...

    Authors: Robert N Peck, Rehema Shedafa, Samuel Kalluvya, Jennifer A Downs, Jim Todd, Manikkam Suthanthiran, Daniel W Fitzgerald and Johannes B Kataraihya
    Citation: BMC Medicine 2014 12:125
  27. The Mediterranean diet has been linked to a number of health benefits, including reduced mortality risk and lower incidence of cardiovascular disease. Definitions of the Mediterranean diet vary across some set...

    Authors: Antonia Trichopoulou, Miguel A Martínez-González, Tammy YN Tong, Nita G Forouhi, Shweta Khandelwal, Dorairaj Prabhakaran, Dariush Mozaffarian and Michel de Lorgeril
    Citation: BMC Medicine 2014 12:112
  28. Recent transcriptomic studies revived a hypothesis suggested by historical studies in rabbits that the ratio of peripheral blood monocytes to lymphocytes (ML) is associated with risk of tuberculosis (TB) disea...

    Authors: Vivek Naranbhai, Soyeon Kim, Helen Fletcher, Mark F Cotton, Avy Violari, Charles Mitchell, Sharon Nachman, George McSherry, Helen McShane, Adrian VS Hill and Shabir A Madhi
    Citation: BMC Medicine 2014 12:120
  29. The impact of diabetes mellitus in patients with multiple system injuries remains obscure. This study was designed to increase knowledge of outcomes of polytrauma in patients who have diabetes mellitus.

    Authors: James Tebby, Fiona Lecky, Antoinette Edwards, Tom Jenks, Omar Bouamra, Rozalia Dimitriou and Peter V Giannoudis
    Citation: BMC Medicine 2014 12:111
  30. Preterm birth (PB) and fetal growth restriction (FGR) convey the highest risk of perinatal mortality and morbidity, as well as increasing the chance of developing chronic disease in later life. Identifying ear...

    Authors: Léa Maitre, Eleni Fthenou, Toby Athersuch, Muireann Coen, Mireille B Toledano, Elaine Holmes, Manolis Kogevinas, Leda Chatzi and Hector C Keun
    Citation: BMC Medicine 2014 12:110
  31. The RTS,S malaria vaccine is currently undergoing phase 3 trials. High vaccine-induced antibody titres to the circumsporozoite protein (CSP) antigen have been associated with protection from infection and epis...

    Authors: Michael T White, Philip Bejon, Ally Olotu, Jamie T Griffin, Kalifa Bojang, John Lusingu, Nahya Salim, Salim Abdulla, Nekoye Otsyula, Selidji T Agnandji, Bertrand Lell, Kwaku Poku Asante, Seth Owusu-Agyei, Emmanuel Mahama, Tsiri Agbenyega, Daniel Ansong…
    Citation: BMC Medicine 2014 12:117
  32. Recently, the World Health Organization (WHO) declared that the spread of polio is an international public health emergency, and a coordinated international response is sought. Although the importance of such ...

    Authors: Mohammad Ali and David A Sack
    Citation: BMC Medicine 2014 12:116
  33. Treatment burden refers to the workload imposed by healthcare on patients, and the effect this has on quality of life. The Treatment Burden Questionnaire (TBQ) aims to assess treatment burden in different cond...

    Authors: Viet-Thi Tran, Magdalena Harrington, Victor M Montori, Caroline Barnes, Paul Wicks and Philippe Ravaud
    Citation: BMC Medicine 2014 12:109