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  1. Despite the worldwide increasing burden of diabetes, there has been no corresponding scale-up of treatment in developing countries and limited evidence of program effectiveness. In 2002, in collaboration with ...

    Authors: Marie-Eve Raguenaud, Petros Isaakidis, Tony Reid, Say Chy, Lim Keuky, Gemma Arellano and Wim Van Damme
    Citation: BMC Medicine 2009 7:33
  2. A meta-analysis was performed to evaluate the use of clinical pathways for hip and knee joint replacements when compared with standard medical care. The impact of clinical pathways was evaluated assessing the ...

    Authors: A Barbieri, K Vanhaecht, P Van Herck, W Sermeus, F Faggiano, S Marchisio and M Panella
    Citation: BMC Medicine 2009 7:32
  3. Unprecedented declines in invasive breast cancer rates occurred in the United States between 2001 and 2004, particularly for estrogen receptor-positive tumors among non-Hispanic white women over 50 years. To u...

    Authors: Amelia K Hausauer, Theresa HM Keegan, Ellen T Chang, Sally L Glaser, Holly Howe and Christina A Clarke
    Citation: BMC Medicine 2009 7:31
  4. Increasing hospital-acquired infections have generated much attention over the last decade. There is evidence that hygienic cleaning has a role in the control of hospital-acquired infections. This study aimed ...

    Authors: Stephanie J Dancer, Liza F White, Jim Lamb, E Kirsty Girvan and Chris Robertson
    Citation: BMC Medicine 2009 7:28
  5. Mobile health clinics provide an alternative portal into the healthcare system for the medically disenfranchised, that is, people who are underinsured, uninsured or who are otherwise outside of mainstream heal...

    Authors: Nancy E Oriol, Paul J Cote, Anthony P Vavasis, Jennifer Bennet, Darien DeLorenzo, Philip Blanc and Isaac Kohane
    Citation: BMC Medicine 2009 7:27
  6. Varicella is a common viral disease affecting almost the entire birth cohort. Although usually self-limiting, some cases of varicella can be serious, with 2 to 6% of cases attending a general practice resultin...

    Authors: Paolo Bonanni, Judith Breuer, Anne Gershon, Michael Gershon, Waleria Hryniewicz, Vana Papaevangelou, Bernard Rentier, Hans Rümke, Catherine Sadzot-Delvaux, Jacques Senterre, Catherine Weil-Olivier and Peter Wutzler
    Citation: BMC Medicine 2009 7:26
  7. Hemodialysis patients are at risk for deficiency of essential trace elements and excess of toxic trace elements, both of which can affect health. We conducted a systematic review to summarize existing literatu...

    Authors: Marcello Tonelli, Natasha Wiebe, Brenda Hemmelgarn, Scott Klarenbach, Catherine Field, Braden Manns, Ravi Thadhani and John Gill
    Citation: BMC Medicine 2009 7:25
  8. Contrast-induced nephropathy is the leading cause of in-hospital acute renal failure. This side effect of contrast agents leads to increased morbidity, mortality, and health costs. Ensuring adequate hydration ...

    Authors: Pascal Meier, Dennis T Ko, Akira Tamura, Umesh Tamhane and Hitinder S Gurm
    Citation: BMC Medicine 2009 7:23
  9. Diarrhea causes an estimated 2.5 million child deaths in developing countries each year, 35% of which are due to acute diarrhea. Zinc and copper stores in the body are known to be depleted during acute diarrhe...

    Authors: Archana Patel, Michael J Dibley, Manju Mamtani, Neetu Badhoniya and Hemant Kulkarni
    Citation: BMC Medicine 2009 7:22
  10. Liver fibrosis is a stage of non-alcoholic fatty liver disease (NAFLD) which is responsible for liver-related morbidity and mortality in adults. Accordingly, the search for non-invasive markers of liver fibros...

    Authors: Valerio Nobili, Anna Alisi, Andrea Vania, Claudio Tiribelli, Andrea Pietrobattista and Giorgio Bedogni
    Citation: BMC Medicine 2009 7:21
  11. Anaesthesia guidelines recommend regional anaesthesia for most caesarean sections due to the risk of failed intubation and aspiration with general anaesthesia. However, general anaesthesia is considered to be ...

    Authors: Charles S Algert, Jennifer R Bowen, Warwick B Giles, Greg E Knoblanche, Samantha J Lain and Christine L Roberts
    Citation: BMC Medicine 2009 7:20
  12. Rifampin is a key drug in antituberculosis chemotherapy because it rapidly kills the majority of bacilli in tuberculosis lesions, prevents relapse and thus enables 6-month short-course chemotherapy. Little is ...

    Authors: Hendrik Simon Schaaf, Marianne Willemse, Karien Cilliers, Demetre Labadarios, Johannes Stephanus Maritz, Gregory D Hussey, Helen McIlleron, Peter Smith and Peter Roderick Donald
    Citation: BMC Medicine 2009 7:19
  13. Colorectal cancer is generally diagnosed following a symptomatic presentation to primary care. Although the presenting features of the cancer are well described, the risks they convey are less well known. This...

    Authors: William Hamilton, Robert Lancashire, Debbie Sharp, Tim J Peters, KK Cheng and Tom Marshall
    Citation: BMC Medicine 2009 7:17
  14. When this trial was initiated, the combined measles, mumps and rubella (MMR) vaccine was licensed for subcutaneous administration in all European countries and for intramuscular administration in some countrie...

    Authors: Yves Gillet, Pirmin Habermehl, Stéphane Thomas, Cécile Eymin and Anne Fiquet
    Citation: BMC Medicine 2009 7:16
  15. Hepatitis B outbreaks in healthcare settings are still a serious public health concern in high-income countries. To elucidate the most frequent infection pathways and clinical settings involved, we performed a...

    Authors: Simone Lanini, Vincenzo Puro, Francesco N Lauria, Francesco M Fusco, Carla Nisii and Giuseppe Ippolito
    Citation: BMC Medicine 2009 7:15
  16. Spinal muscular atrophy (SMA) is a neurodegenerative disorder associated with mutations of the survival motor neuron gene SMN and is characterized by muscle weakness and atrophy caused by degeneration of spinal m...

    Authors: Caterina Millino, Marina Fanin, Andrea Vettori, Paolo Laveder, Maria Luisa Mostacciuolo, Corrado Angelini and Gerolamo Lanfranchi
    Citation: BMC Medicine 2009 7:14
  17. Intradermal vaccination provides direct and potentially more efficient access to the immune system via specialised dendritic cells and draining lymphatic vessels. We investigated the immunogenicity and safety ...

    Authors: Jiri Beran, Arvydas Ambrozaitis, Alvydas Laiskonis, Narseta Mickuviene, Patrick Bacart, Yvan Calozet, Etienne Demanet, Stephane Heijmans, Paul Van Belle, Françoise Weber and Camille Salamand
    Citation: BMC Medicine 2009 7:13
  18. Proteinuria is a defining criterion for the diagnosis of pre-eclampsia. The amount of protein lost per day has been thought by some to predict both maternal and fetal outcome. The systematic review of 16 prima...

    Authors: G Justus Hofmeyr and Michael Belfort
    Citation: BMC Medicine 2009 7:11
  19. Proteinuria is one of the essential criteria for the clinical diagnosis of pre-eclampsia. Increasing levels of proteinuria is considered to be associated with adverse maternal and fetal outcomes. We aim to det...

    Authors: Shakila Thangaratinam, Arri Coomarasamy, Fidelma O'Mahony, Steve Sharp, Javier Zamora, Khalid S Khan and Khaled MK Ismail
    Citation: BMC Medicine 2009 7:10
  20. Tumor metastases pose the greatest threat to a patient's survival, and thus, understanding the biology of disseminated cancer cells is critical for developing effective therapies.

    Authors: Zhiyuan Hu, Cheng Fan, Chad Livasy, Xiaping He, Daniel S Oh, Matthew G Ewend, Lisa A Carey, Subbaya Subramanian, Robert West, Francis Ikpatt, Olufunmilayo I Olopade, Matt van de Rijn and Charles M Perou
    Citation: BMC Medicine 2009 7:9
  21. Sexually transmitted infections constitute the main health risk among adolescents. In developing countries the diagnosis and treatment of cervical infections is based on the syndromic approach. In this study w...

    Authors: Eleuse MB Guimarães, Mark DC Guimarães, Maria Aparecida S Vieira, Nádia M Bontempo, Mirian SS Seixas, Mônica SD Garcia, Lyana ES Daud, Rejane LM Côrtes and Maria de Fátima C Alves
    Citation: BMC Medicine 2009 7:8
  22. Alzheimer's disease is a devastating neurological disorder that affects more than 37 million people worldwide. The economic burden of Alzheimer's disease is massive; in the United States alone, the estimated d...

    Authors: Michael S Rafii and Paul S Aisen
    Citation: BMC Medicine 2009 7:7
  23. One of the factors that limits survival from out-of-hospital cardiac arrest is the interruption of chest compressions. During ventricular fibrillation and tachycardia the electrocardiogram reflects the probabi...

    Authors: Kenneth Gundersen, Jan Terje Kvaløy, Jo Kramer-Johansen, Petter Andreas Steen and Trygve Eftestøl
    Citation: BMC Medicine 2009 7:6
  24. Understanding how bone (BM), lean (LM) and fat mass (FM) develop through childhood, puberty and adolescence is vital since it holds key information regarding current and future health. Our study aimed to deter...

    Authors: Sulin Cheng, Eszter Völgyi, Frances A Tylavsky, Arja Lyytikäinen, Timo Törmäkangas, Leiting Xu, Shu Mei Cheng, Heikki Kröger, Markku Alèn and Urho M Kujala
    Citation: BMC Medicine 2009 7:5
  25. Vertical and horizontal trust, as dimensions of social capital, may be important determinants of health. As mass media campaigns have been used extensively to promote healthy lifestyles and convey health-relat...

    Authors: Yasuharu Tokuda, Seiji Fujii, Masamine Jimba and Takashi Inoguchi
    Citation: BMC Medicine 2009 7:4
  26. In November 2008, BMC Medicine passed the landmark of its first 5 years of publishing. When we launched the journal with the aim of publishing high quality research of general interest and special importance, we ...

    Authors: Joanne M Appleford, Robin L Cassady-Cain, Jigisha Patel and Melissa L Norton
    Citation: BMC Medicine 2009 7:3
  27. Most patients with chronic obstructive pulmonary disease (COPD) receive inhaled long-acting bronchodilators and inhaled corticosteroids. Conventional meta-analyses established that these drugs reduce COPD exac...

    Authors: Milo A Puhan, Lucas M Bachmann, Jos Kleijnen, Gerben ter Riet and Alphons G Kessels
    Citation: BMC Medicine 2009 7:2
  28. There is accumulating evidence for a link between trauma exposure, posttraumatic stress disorder (PTSD) and diminished health status. To assess PTSD-related biological burden, we measured biological factors th...

    Authors: Pia S Heppner, Eric F Crawford, Uzair A Haji, Niloofar Afari, Richard L Hauger, Boris A Dashevsky, Paul S Horn, Sarah E Nunnink and Dewleen G Baker
    Citation: BMC Medicine 2009 7:1
  29. Alzheimer's disease (AD) is characterized by neurodegeneration and changes in cellular processes, including neurogenesis. Proteolytic processing of the amyloid precursor protein (APP) plays a central role in A...

    Authors: Markus Uhrig, Peter Brechlin, Olaf Jahn, Yuri Knyazev, Annette Weninger, Laura Busia, Kamran Honarnejad, Markus Otto and Tobias Hartmann
    Citation: BMC Medicine 2008 6:38
  30. The internet has had a strong impact on how physicians access information and on the development of continuing medical education activities. Evaluation of the effectiveness of these activities has lagged behin...

    Authors: Linda Casebeer, Sally Engler, Nancy Bennett, Martin Irvine, Destry Sulkes, Marc DesLauriers and Sijian Zhang
    Citation: BMC Medicine 2008 6:37
  31. Excessive alcohol use increases risks of chronic diseases such as coronary heart disease and several types of cancer, with associated losses of quality of life and life-years. Alcohol taxes can be considered a...

    Authors: Matthijs van den Berg, Pieter HM van Baal, Luqman Tariq, Albertine J Schuit, G Ardine de Wit and Rudolf T Hoogenveen
    Citation: BMC Medicine 2008 6:36
  32. Use of fenfluramines for weight loss has been associated with the development of characteristic plaques on cardiac valves causing regurgitation. However, previously published studies of exposure to fenfluramin...

    Authors: Charles F Dahl, Marvin R Allen, Paul M Urie and Paul N Hopkins
    Citation: BMC Medicine 2008 6:34
  33. We report age-dependent penetrance estimates for leucine-rich repeat kinase 2 (LRRK2)-related Parkinson's disease (PD) in a large sample of familial PD. The most frequently seen LRRK2 mutation, Gly2019Ser (G2019S...

    Authors: Jeanne C Latourelle, Mei Sun, Mark F Lew, Oksana Suchowersky, Christine Klein, Lawrence I Golbe, Margery H Mark, John H Growdon, G Frederick Wooten, Ray L Watts, Mark Guttman, Brad A Racette, Joel S Perlmutter, Anwar Ahmed, Holly A Shill, Carlos Singer…
    Citation: BMC Medicine 2008 6:32
  34. Twenty-five years after the discovery and isolation of the human immunodeficiency virus by French and American scientists, much progress has been made in basic research, clinical treatment, and public health p...

    Authors: Mark A Wainberg and Kuan-Teh Jeang
    Citation: BMC Medicine 2008 6:31
  35. Recent genome wide association (GWA) studies identified two Single Nucleotide Polymorphisms (SNP) (rs10757278 and rs10757274) in the region of the CDK2NA and CDK2NB genes to be consistently associated with the...

    Authors: Abbas Dehghan, Mandy van Hoek, Eric JG Sijbrands, Ben A Oostra, Albert Hofman, Cornelia M van Duijn and Jacqueline CM Witteman
    Citation: BMC Medicine 2008 6:30
  36. Randomised trials comparing different drugs head-to-head are extremely valuable for clinical decision-making. However, it is scientifically and ethically sensible to demand strong evidence that a drug is effec...

    Authors: Milo A Puhan, Daniela Vollenweider, Johann Steurer, Patrick M Bossuyt and Gerben ter Riet
    Citation: BMC Medicine 2008 6:28
  37. We have engaged in an international program designated the Bank On A Cure, which has established DNA banks from multiple cooperative and institutional clinical trials, and a platform for examining the association...

    Authors: Brian Van Ness, Christine Ramos, Majda Haznadar, Antje Hoering, Jeff Haessler, John Crowley, Susanna Jacobus, Martin Oken, Vincent Rajkumar, Philip Greipp, Bart Barlogie, Brian Durie, Michael Katz, Gowtham Atluri, Gang Fang, Rohit Gupta…
    Citation: BMC Medicine 2008 6:26
  38. Animal data show that decreased activity of placental 11-beta-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which potently inactivates glucocorticoids (e.g. cortisol) to inert forms (cortisone), allows incre...

    Authors: Susanna Y Huh, Ruth Andrew, Janet W Rich-Edwards, Ken P Kleinman, Jonathan R Seckl and Matthew W Gillman
    Citation: BMC Medicine 2008 6:25
  39. Severe anemia due to Plasmodium falciparum malaria is a major cause of mortality among young children in western Kenya. The factors that lead to the age-specific incidence of this anemia are unknown. Previous stu...

    Authors: Collins O Odhiambo, Walter Otieno, Christine Adhiambo, Michael M Odera and José A Stoute
    Citation: BMC Medicine 2008 6:23
  40. Neurofibromatosis type 1 (NF1) is a dominantly inherited multi-system disorder. Major features include pigmentary abnormalities, benign tumors of the nerve sheath (neurofibromas), malignant tumors, learning di...

    Authors: Bruce R Korf
    Citation: BMC Medicine 2008 6:22