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  1. Rheumatoid arthritis (RA) is associated with increased cardiovascular risk. Treatment with tumor necrosis factor (TNF)-inhibitors leads to about a 50% reduction in the first cardiovascular event. TNF-inhibitor...

    Authors: Nemanja Damjanov, Michael T Nurmohamed and Zoltán Szekanecz
    Citation: BMC Medicine 2014 12:48
  2. Immunologic research into pathogenic mechanisms operating in autoimmune-mediated atherosclerosis initially focused on adaptive immunity. Current interest is directed to more basic inflammatory mechanisms. Chro...

    Authors: Eiji Matsuura, Fabiola Atzeni, Piercarlo Sarzi-Puttini, Maurizio Turiel, Luis R Lopez and Michael T Nurmohamed
    Citation: BMC Medicine 2014 12:47
  3. Antiretroviral therapy (ART) and oral pre-exposure prophylaxis (PrEP) are effective in reducing HIV transmission in heterosexual adults. The epidemiologic impact and cost-effectiveness of combined prevention a...

    Authors: Sabina S Alistar, Philip M Grant and Eran Bendavid
    Citation: BMC Medicine 2014 12:46
  4. Adiposity is associated with many adverse health outcomes but little direct evidence exists about its impact on the use of health care services. We aim to describe the relationship between body mass index (BMI...

    Authors: Gillian K Reeves, Angela Balkwill, Benjamin J Cairns, Jane Green and Valerie Beral
    Citation: BMC Medicine 2014 12:45
  5. In this podcast, we talk to Professor Vikram Patel about the impact of global mental health in the field of medicine, and discuss the initiatives and platforms being developed to promote capacity building, res...

    Authors: Vikram Patel
    Citation: BMC Medicine 2014 12:44
  6. Being married has been associated with a lower mortality from ischemic heart disease (IHD) in men, but there is less evidence of an association for women, and it is unclear whether the associations with being ...

    Authors: Sarah Floud, Angela Balkwill, Dexter Canoy, F Lucy Wright, Gillian K Reeves, Jane Green, Valerie Beral and Benjamin J Cairns
    Citation: BMC Medicine 2014 12:42
  7. The hypothesis of this study was that local anesthesia with monitored anesthesia care (MAC) is not harmful in comparison to general anesthesia (GA) for patients undergoing Transcatheter Aortic Valve Implantati...

    Authors: Georg M Fröhlich, Alexandra J Lansky, John Webb, Marco Roffi, Stefan Toggweiler, Markus Reinthaler, Duolao Wang, Nevil Hutchinson, Olaf Wendler, David Hildick-Smith and Pascal Meier
    Citation: BMC Medicine 2014 12:41
  8. Ten years after the first proposal, a consensus definition of healthcare-associated infection (HCAI) has not been reached, preventing the development of specific treatment recommendations. A systematic review ...

    Authors: Teresa Cardoso, Mónica Almeida, N Deborah Friedman, Irene Aragão, Altamiro Costa-Pereira, António E Sarmento and Luís Azevedo
    Citation: BMC Medicine 2014 12:40
  9. This study aims to determine the incidence of pulmonary embolism (PE) in trauma and orthopedic patients within a regional tertiary referral center and its association with the pattern of injury, type of treatm...

    Authors: Suribabu Gudipati, Evangelos M Fragkakis, Vincenzo Ciriello, Simon J Harrison, Petros Z Stavrou, Nikolaos K Kanakaris, Robert M West and Peter V Giannoudis
    Citation: BMC Medicine 2014 12:39
  10. Anti-nuclear antibody (ANA) assay is a screening test used for almost all autoimmune rheumatic diseases, and in a number of these cases, it is a diagnostic/classification parameter. In addition, ANA is also a ...

    Authors: Pier Luigi Meroni, Nicola Bizzaro, Ilaria Cavazzana, Maria Orietta Borghi and Angela Tincani
    Citation: BMC Medicine 2014 12:38
  11. An increasing number of studies show that besides the inherited genetic architecture (that is, genomic DNA), various environmental factors significantly contribute to the etiology of rheumatoid arthritis. Epig...

    Authors: Tibor T Glant, Katalin Mikecz and Tibor A Rauch
    Citation: BMC Medicine 2014 12:35
  12. Overexpression of autologous proteins can lead to the formation of autoantibodies and autoimmune diseases. MHC class I polypeptide-related sequence A (MICA) is highly expressed in the enterocytes of patients w...

    Authors: Antonio López-Vázquez, Lourdes Mozo, Rebeca Alonso-Arias, Beatriz Suárez-Álvarez, José Ramón Vidal-Castiñeira, Eduardo Arranz, Umberto Volta, Carlos Bousoño, Marcos López-Hoyos, Luís Rodrigo and Carlos López-Larrea
    Citation: BMC Medicine 2014 12:34
  13. The fast pace of technological improvement and the rapid development and adoption of healthcare applications present crucial challenges for clinicians, users and policy makers. Some of the most pressing dilemm...

    Authors: Esmita Charani, Enrique Castro-Sánchez, Luke SP Moore and Alison Holmes
    Citation: BMC Medicine 2014 12:29
  14. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are commonly prescribed to the growing number of cancer patients (more than two million in the UK alone) often to tr...

    Authors: Chris R Cardwell, Úna C Mc Menamin, Blánaid M Hicks, Carmel Hughes, Marie M Cantwell and Liam J Murray
    Citation: BMC Medicine 2014 12:28
  15. The prevalence of chronic kidney disease (CKD) increases with age, and new glomerular filtration rate-estimating equations have recently been validated. The epidemiology of CKD in older individuals and the rel...

    Authors: Gijs Van Pottelbergh, Bert Vaes, Wim Adriaensen, Cathy Matheï, Delphine Legrand, Pierre Wallemacq and Jean Marie Degryse
    Citation: BMC Medicine 2014 12:27
  16. Prostate cancer screening depends on a careful balance of benefits, in terms of reduced prostate cancer mortality, and harms, in terms of overdiagnosis and overtreatment. We aimed to estimate the effect on ove...

    Authors: Andrew J Vickers, Daniel D Sjoberg, David Ulmert, Emily Vertosick, Monique J Roobol, Ian Thompson, Eveline AM Heijnsdijk, Harry De Koning, Coral Atoria-Swartz, Peter T Scardino and Hans Lilja
    Citation: BMC Medicine 2014 12:26
  17. Despite considerable advances in the management of rheumatoid arthritis, results are still not satisfactory for all patients. The treatment goal in rheumatoid arthritis is remission, and there currently are nu...

    Authors: Ronald F van Vollenhoven, György Nagy and Paul P Tak
    Citation: BMC Medicine 2014 12:25
  18. This comment relates to articles published in archived content of the journal Head and Neck Oncology and is not related to the content of BMC Medicine in any way.

    Authors:
    Citation: BMC Medicine 2014 12:24
  19. Computer-coded verbal autopsy (CCVA) methods to assign causes of death (CODs) for medically unattended deaths have been proposed as an alternative to physician-certified verbal autopsy (PCVA). We conducted a s...

    Authors: Jordana Leitao, Nikita Desai, Lukasz Aleksandrowicz, Peter Byass, Pierre Miasnikof, Stephen Tollman, Dewan Alam, Ying Lu, Suresh Kumar Rathi, Abhishek Singh, Wilson Suraweera, Faujdar Ram and Prabhat Jha
    Citation: BMC Medicine 2014 12:22
  20. Verbal autopsy (VA) has been proposed to determine the cause of death (COD) distributions in settings where most deaths occur without medical attention or certification. We develop performance criteria for VA-...

    Authors: Lukasz Aleksandrowicz, Varun Malhotra, Rajesh Dikshit, Prakash C Gupta, Rajesh Kumar, Jay Sheth, Suresh Kumar Rathi, Wilson Suraweera, Pierre Miasnikof, Raju Jotkar, Dhirendra Sinha, Shally Awasthi, Prakash Bhatia and Prabhat Jha
    Citation: BMC Medicine 2014 12:21
  21. Physician-coded verbal autopsy (PCVA) is the most widely used method to determine causes of death (CODs) in countries where medical certification of death is uncommon. Computer-coded verbal autopsy (CCVA) meth...

    Authors: Nikita Desai, Lukasz Aleksandrowicz, Pierre Miasnikof, Ying Lu, Jordana Leitao, Peter Byass, Stephen Tollman, Paul Mee, Dewan Alam, Suresh Kumar Rathi, Abhishek Singh, Rajesh Kumar, Faujdar Ram and Prabhat Jha
    Citation: BMC Medicine 2014 12:20
  22. Verbal autopsy is a method for assessing probable causes of death from lay reporting of signs, symptoms and circumstances by family members or caregivers of a deceased person. Several methods of automated diag...

    Authors: Michel Garenne
    Citation: BMC Medicine 2014 12:18
  23. In this study, a combination of recombinant adenoviral p53 (rAd-p53) gene therapy and intra-arterial delivery of chemotherapeutic agents for treatment of oral squamous cell carcinoma was evaluated.

    Authors: Yi Li, Long-Jiang Li, Li-Juan Wang, Zhuang Zhang, Ning Gao, Chen-Yuan Liang, Yuan-Ding Huang and Bo Han
    Citation: BMC Medicine 2014 12:16
  24. Research collaboration contributes to the advancement of knowledge by exploiting the results of scientific efforts more efficiently, but the global patterns of collaboration on meta-analysis are unknown. The p...

    Authors: Ferrán Catalá-López, Adolfo Alonso-Arroyo, Brian Hutton, Rafael Aleixandre-Benavent and David Moher
    Citation: BMC Medicine 2014 12:15
  25. The United States Preventive Services Task Force (USPSTF) recommends screening adults for depression in primary care settings when staff-assisted depression management programs are available. This recommendati...

    Authors: Brett D Thombs, Roy C Ziegelstein, Michelle Roseman, Lorie A Kloda and John PA Ioannidis
    Citation: BMC Medicine 2014 12:13
  26. In recognition of Open Access week (21st-27th October 2013), we asked some BMC Medicine Editorial Board Members to share their views and experiences on open access publishing. In this short video, they highlight ...

    Authors: Michael R Carmont, Stephen D Lawn, Babill Stray-Pedersen, Yehuda Shoenfeld and Pascal Meier
    Citation: BMC Medicine 2014 12:10
  27. The editors of BMC Medicine would like to thank all our reviewers who have contributed to the journal in Volume 11 (2013).

    Authors: Sabina Alam
    Citation: BMC Medicine 2014 12:9
  28. Major depression is a disabling psychiatric illness with complex origins. Life stress (childhood adversity and recent stressful events) is a robust risk factor for depression. The relationship between life str...

    Authors: Georgina M Hosang, Celia Shiles, Katherine E Tansey, Peter McGuffin and Rudolf Uher
    Citation: BMC Medicine 2014 12:7
  29. More than three decades after the 1978 Declaration of Alma-Ata enshrined the goal of ‘health for all’, high-quality primary care services remain undelivered to the great majority of the world’s poor. This fail...

    Authors: Ashwin Vasan, Andrew Ellner, Stephen D Lawn, Sandy Gove, Manzi Anatole, Neil Gupta, Peter Drobac, Tom Nicholson, Kwonjune Seung, David C Mabey and Paul E Farmer
    Citation: BMC Medicine 2014 12:6
  30. Monitoring progress with disease and injury reduction in many populations will require widespread use of verbal autopsy (VA). Multiple methods have been developed for assigning cause of death from a VA but the...

    Authors: Christopher JL Murray, Rafael Lozano, Abraham D Flaxman, Peter Serina, David Phillips, Andrea Stewart, Spencer L James, Alireza Vahdatpour, Charles Atkinson, Michael K Freeman, Summer Lockett Ohno, Robert Black, Said Mohammed Ali, Abdullah H Baqui, Lalit Dandona, Emily Dantzer…
    Citation: BMC Medicine 2014 12:5
  31. On 24 November 2003, BMC Medicine published its first article. Ten years and over 900 articles later we look back at some of the most notable milestones for the journal and discuss advances and innovations in med...

    Authors: Sabina Alam and Jigisha Patel
    Citation: BMC Medicine 2014 12:4
  32. Asia accounts for 60% of the world population and half the global burden of cancer. The incidence of cancer cases is estimated to increase from 6.1 million in 2008 to 10.6 million in 2030, due to ageing and gr...

    Authors: Rengaswamy Sankaranarayanan, Kunnambath Ramadas and You-lin Qiao
    Citation: BMC Medicine 2014 12:3
  33. Although the use of bortezomib alone and in combination with steroids has shown efficacy in AL amyloidosis, its role in combination with high-dose melphalan and autologous stem cell transplantation (HDM/SCT) i...

    Authors: Xianghua Huang, Qingwen Wang, Wencui Chen, Caihong Zeng, Zhaohong Chen, Dehua Gong, Haitao Zhang and Zhihong Liu
    Citation: BMC Medicine 2014 12:2
  34. The ‘Older People’s Exercise intervention in Residential and nursing Accommodation’ (OPERA) cluster randomised trial evaluated the impact of training for care home staff together with twice-weekly, physiothera...

    Authors: David R Ellard, Margaret Thorogood, Martin Underwood, Clive Seale and Stephanie JC Taylor
    Citation: BMC Medicine 2014 12:1