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  1. Most of newly discovered cancer biomarkers fail in the clinic because they lack sensitivity and/or specificity. The current explosion in knowledge of the mutational spectrum of many cancer types, as a result o...

    Authors: Eleftherios P Diamandis
    Citation: BMC Medicine 2014 12:156
    Content type: Opinion Published on:

  2. Several non-invasive prediction scores for non-alcoholic fatty liver disease (NAFLD) have been developed, but their performance has not been compared and validated in the same population, and whether these pre...

    Authors: Ching-Lung Cheung, Karen SL Lam, Ian CK Wong and Bernard MY Cheung
    Citation: BMC Medicine 2014 12:154
    Content type: Research article Published on:

  3. Identifying Plasmodium vivax antigen-specific antibodies associated with P. vivax infection and protective immunity is key to the development of serosurveillance tools and vaccines for malaria. Antibody targets o...

    Authors: Julia C Cutts, Rosanna Powell, Paul A Agius, James G Beeson, Julie A Simpson and Freya J I Fowkes
    Citation: BMC Medicine 2014 12:150
    Content type: Research article Published on:

  6. Dengue is emerging as one of the most abundant vector-borne disease globally. Although the majority of infections are asymptomatic or result in only a brief systemic viral illness, a small proportion of patien...

    Authors: Sophie Yacoub and Bridget Wills
    Citation: BMC Medicine 2014 12:147
    Content type: Review Published on:

  8. Do-Not-Resuscitate (DNR) patients tend to receive less medical care after the order is written. To provide a clearer approach, the Ohio Department of Health adopted the Do-Not-Resuscitate law in 1998, indicati...

    Authors: Yen-Yuan Chen, Nahida H Gordon, Alfred F Connors, Allan Garland, Shan-Chwen Chang and Stuart J Youngner
    Citation: BMC Medicine 2014 12:146
    Content type: Research article Published on:

  9. A link between measles virus and Crohn’s disease (CD) has been postulated. We assessed through bioinformatic and immunological approaches whether measles is implicated in CD induction, through molecular mimicry.

    Authors: Dimitrios Polymeros, Zacharias P Tsiamoulos, Andreas L Koutsoumpas, Daniel S Smyk, Maria G Mytilinaiou, Konstantinos Triantafyllou, Dimitrios P Bogdanos and Spiros D Ladas
    Citation: BMC Medicine 2014 12:139
    Content type: Research article Published on:

  10. Obesity and metabolic syndrome are healthcare problems that continue to rise in frequency worldwide. Both phenotypes are a strong predictor for development of liver steatosis in the context of non-alcoholic fa...

    Authors: Bark Betzel and Joost PH Drenth
    Citation: BMC Medicine 2014 12:152
    Content type: Commentary Published on:

  12. Non-alcoholic fatty liver disease (NAFLD) is caused by abnormal accumulation of lipids within liver cells. Its prevalence is increasing in developed countries in association with obesity, and it represents a r...

    Authors: Raúl Jiménez-Agüero, José I Emparanza, Adolfo Beguiristain, Luis Bujanda, José M Alustiza, Elisabeth García, Elizabeth Hijona, Lander Gallego, Javier Sánchez-González, María J Perugorria, José I Asensio, Santiago Larburu, Maddi Garmendia, Mikel Larzabal, María P Portillo, Leixuri Aguirre…
    Citation: BMC Medicine 2014 12:137
    Content type: Research article Published on:

  14. Although obesity and diabetes commonly co-exist, the evidence base to support obesity as the major driver of type 2 diabetes mellitus (T2DM), and the mechanisms by which this occurs, are now better appreciated.

    Authors: Naveed Sattar and Jason MR Gill
    Citation: BMC Medicine 2014 12:123
    Content type: Opinion Published on:

  16. Much research is underway on the links between diet and obesity. So too are long-running disputes among nutritionists on core questions about the relationship. This editorial reviews the state-of-play on four ...

    Authors: Jack Winkler
    Citation: BMC Medicine 2014 12:114
    Content type: Editorial Published on:

  17. Adherence to combination antiretroviral therapy (ART) is a key predictor of the success of human immunodeficiency virus (HIV) treatment, and is potentially amenable to intervention. Insight into predictors or ...

    Authors: Nienke Langebeek, Elizabeth H Gisolf, Peter Reiss, Sigrid C Vervoort, Thóra B Hafsteinsdóttir, Clemens Richter, Mirjam AG Sprangers and Pythia T Nieuwkerk
    Citation: BMC Medicine 2014 12:142
    Content type: Research article Published on:

  18. The impact of mental disorders among homeless people is likely to be substantial in low income countries because of underdeveloped social welfare and health systems. As a first step towards advocacy and provis...

    Authors: Abebaw Fekadu, Charlotte Hanlon, Emebet Gebre-Eyesus, Melkamu Agedew, Haddis Solomon, Solomon Teferra, Tsehaysina Gebre-Eyesus, Yonas Baheretibeb, Girmay Medhin, Teshome Shibre, Abraham Workneh, Teketel Tegegn, Alehegn Ketema, Philip Timms, Graham Thornicroft and Martin Prince
    Citation: BMC Medicine 2014 12:138
    Content type: Research article Published on:

  20. Text recycling, also referred to as self-plagiarism, is the reproduction of an author’s own text from a previous publication in a new publication. Opinions on the acceptability of this practice vary, with some...

    Authors: Stephanie Harriman and Jigisha Patel
    Citation: BMC Medicine 2014 12:148
    Content type: Editorial Published on:

  21. Environmental enteric dysfunction (EED) is an acquired syndrome of impaired gastrointestinal mucosal barrier function that is thought to play a key role in the pathogenesis of stunting in early life. It has be...

    Authors: Kelsey DJ Jones, Barbara Hünten-Kirsch, Ahmed MR Laving, Caroline W Munyi, Moses Ngari, Jenifer Mikusa, Musa M Mulongo, Dennis Odera, H Samira Nassir, Molline Timbwa, Moses Owino, Greg Fegan, Simon H Murch, Peter B Sullivan, John O Warner and James A Berkley
    Citation: BMC Medicine 2014 12:133
    Content type: Research article Published on:

  22. Next generation sequencing (NGS) coupled with sophisticated bioinformatics tools yields an unprecedented amount of information regarding tumor genetics, with the potential to reveal insights into tumor behavio...

    Authors: Debu Tripathy, Kathleen Harnden, Kimberly Blackwell and Mark Robson
    Citation: BMC Medicine 2014 12:140
    Content type: Forum Published on:

  26. Chronic stress is considered to be one of many causes of human preterm birth (PTB), but no direct evidence has yet been provided. Here we show in rats that stress across generations has downstream effects on e...

    Authors: Youli Yao, Alexandra M Robinson, Fabiola CR Zucchi, Jerrah C Robbins, Olena Babenko, Olga Kovalchuk, Igor Kovalchuk, David M Olson and Gerlinde AS Metz
    Citation: BMC Medicine 2014 12:121
    Content type: Research article Published on:

  27. Human infections with avian influenza A(H7N9) virus are associated with severe illness and high mortality. To better inform triage decisions of hospitalization and management, we developed a clinical predictio...

    Authors: Qiaohong Liao, Dennis K M Ip, Tim K Tsang, Bin Cao, Hui Jiang, Fengfeng Liu, Jiandong Zheng, Zhibin Peng, Peng Wu, Yang Huai, Eric H Y Lau, Luzhao Feng, Gabriel M Leung, Hongjie Yu and Benjamin J Cowling
    Citation: BMC Medicine 2014 12:127
    Content type: Research article Published on:

  28. With escalating health expenditure and a shrinking purse, there is increased focus on the cost efficacy of still patented versus generic medications in general, and for atypical antipsychotics in particular. I...

    Authors: Ajeet B Singh, Andrew A Nierenberg, Lakshmi N Yatham and Michael Berk
    Citation: BMC Medicine 2014 12:126
    Content type: Commentary Published on:

  29. Intimate partner violence (IPV) and HIV are important and interconnected public health concerns. While it is recognized that they share common social drivers, there is limited evidence surrounding the potentia...

    Authors: Tanya Abramsky, Karen Devries, Ligia Kiss, Janet Nakuti, Nambusi Kyegombe, Elizabeth Starmann, Bonnie Cundill, Leilani Francisco, Dan Kaye, Tina Musuya, Lori Michau and Charlotte Watts
    Citation: BMC Medicine 2014 12:122
    Content type: Research article Published on:

  31. The epidemics of HIV and hypertension are converging in sub-Saharan Africa. Due to antiretroviral therapy (ART), more HIV-infected adults are living longer and gaining weight, putting them at greater risk for ...

    Authors: Robert N Peck, Rehema Shedafa, Samuel Kalluvya, Jennifer A Downs, Jim Todd, Manikkam Suthanthiran, Daniel W Fitzgerald and Johannes B Kataraihya
    Citation: BMC Medicine 2014 12:125
    Content type: Research article Published on:

  32. The Mediterranean diet has been linked to a number of health benefits, including reduced mortality risk and lower incidence of cardiovascular disease. Definitions of the Mediterranean diet vary across some set...

    Authors: Antonia Trichopoulou, Miguel A Martínez-González, Tammy YN Tong, Nita G Forouhi, Shweta Khandelwal, Dorairaj Prabhakaran, Dariush Mozaffarian and Michel de Lorgeril
    Citation: BMC Medicine 2014 12:112
    Content type: Forum Published on:

  34. Recent transcriptomic studies revived a hypothesis suggested by historical studies in rabbits that the ratio of peripheral blood monocytes to lymphocytes (ML) is associated with risk of tuberculosis (TB) disea...

    Authors: Vivek Naranbhai, Soyeon Kim, Helen Fletcher, Mark F Cotton, Avy Violari, Charles Mitchell, Sharon Nachman, George McSherry, Helen McShane, Adrian VS Hill and Shabir A Madhi
    Citation: BMC Medicine 2014 12:120
    Content type: Research article Published on:

  35. The impact of diabetes mellitus in patients with multiple system injuries remains obscure. This study was designed to increase knowledge of outcomes of polytrauma in patients who have diabetes mellitus.

    Authors: James Tebby, Fiona Lecky, Antoinette Edwards, Tom Jenks, Omar Bouamra, Rozalia Dimitriou and Peter V Giannoudis
    Citation: BMC Medicine 2014 12:111
    Content type: Research article Published on:

  37. Preterm birth (PB) and fetal growth restriction (FGR) convey the highest risk of perinatal mortality and morbidity, as well as increasing the chance of developing chronic disease in later life. Identifying ear...

    Authors: Léa Maitre, Eleni Fthenou, Toby Athersuch, Muireann Coen, Mireille B Toledano, Elaine Holmes, Manolis Kogevinas, Leda Chatzi and Hector C Keun
    Citation: BMC Medicine 2014 12:110
    Content type: Research article Published on:

  38. The RTS,S malaria vaccine is currently undergoing phase 3 trials. High vaccine-induced antibody titres to the circumsporozoite protein (CSP) antigen have been associated with protection from infection and epis...

    Authors: Michael T White, Philip Bejon, Ally Olotu, Jamie T Griffin, Kalifa Bojang, John Lusingu, Nahya Salim, Salim Abdulla, Nekoye Otsyula, Selidji T Agnandji, Bertrand Lell, Kwaku Poku Asante, Seth Owusu-Agyei, Emmanuel Mahama, Tsiri Agbenyega, Daniel Ansong…
    Citation: BMC Medicine 2014 12:117
    Content type: Research article Published on:

  40. Recently, the World Health Organization (WHO) declared that the spread of polio is an international public health emergency, and a coordinated international response is sought. Although the importance of such ...

    Authors: Mohammad Ali and David A Sack
    Citation: BMC Medicine 2014 12:116
    Content type: Commentary Published on:

  41. Treatment burden refers to the workload imposed by healthcare on patients, and the effect this has on quality of life. The Treatment Burden Questionnaire (TBQ) aims to assess treatment burden in different cond...

    Authors: Viet-Thi Tran, Magdalena Harrington, Victor M Montori, Caroline Barnes, Paul Wicks and Philippe Ravaud
    Citation: BMC Medicine 2014 12:109
    Content type: Research article Published on:

  42. An understanding of the mechanisms mediating protective immunity against malaria in humans is currently lacking, but critically important to advance the development of highly efficacious vaccines. Antibodies p...

    Authors: Faith HA Osier, Gaoqian Feng, Michelle J Boyle, Christine Langer, Jingling Zhou, Jack S Richards, Fiona J McCallum, Linda Reiling, Anthony Jaworowski, Robin F Anders, Kevin Marsh and James G Beeson
    Citation: BMC Medicine 2014 12:108
    Content type: Research article Published on:

  43. Daycare attendance is an established risk factor for upper respiratory tract infections (URTI) and acute otitis media (AOM). Whether this results in higher use of healthcare resources during childhood remains ...

    Authors: Marieke LA de Hoog, Roderick P Venekamp, Cornelis K van der Ent, Anne Schilder, Elisabeth AM Sanders, Roger AMJ Damoiseaux, Debby Bogaert, Cuno SPM Uiterwaal, Henriette A Smit and Patricia Bruijning-Verhagen
    Citation: BMC Medicine 2014 12:107
    Content type: Research article Published on:

  44. In a meta-analysis published in BMC Medicine, we explored whether evidence-based medicine can actually be sure that ‘sucrose = sucrose’ in the treatment of depression. This paper, based upon a reductio ad absurdu...

    Authors: Florian Naudet and Bruno Falissard
    Citation: BMC Medicine 2014 12:106
    Content type: Comment Published on:

  45. The placebo response plays a major role in psychiatry, particularly in depression. A new network meta-analysis investigates whether the effects of placebo vary in studies comparing fluoxetine and venlafaxine, ...

    Authors: Andrea Cipriani and John R Geddes
    Citation: BMC Medicine 2014 12:105
    Content type: Commentary Published on:

  46. Palmitic acid, or hexadecanoic acid, a 16-carbon saturated fatty acid (FA), accounts for approximately 38% of the total circulating FA in lean or obese humans. In an article published in BMC Medicine, Hall et al....

    Authors: Delphine Fradin and Pierre Bougnères
    Citation: BMC Medicine 2014 12:104
    Content type: Commentary Published on:

  47. Circulating free fatty acids are often elevated in patients with type 2 diabetes (T2D) and obese individuals. Chronic exposure to high levels of saturated fatty acids has detrimental effects on islet function ...

    Authors: Elin Hall, Petr Volkov, Tasnim Dayeh, Karl Bacos, Tina Rönn, Marloes Dekker Nitert and Charlotte Ling
    Citation: BMC Medicine 2014 12:103
    Content type: Research article Published on:

  49. Tuberculous pericarditis (TBP) is associated with high morbidity and mortality, and is an important treatable cause of heart failure in developing countries. Tuberculous aetiology of pericarditis is difficult ...

    Authors: Shaheen Pandie, Jonathan G Peter, Zita S Kerbelker, Richard Meldau, Grant Theron, Ureshnie Govender, Mpiko Ntsekhe, Keertan Dheda and Bongani M Mayosi
    Citation: BMC Medicine 2014 12:101
    Content type: Research article Published on:
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