Skip to main content

Articles

Page 71 of 86

  1. The furore preceding the release of the new edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) is in contrast to the incremental changes to several diagnostic categories, which are de...

    Authors: Michael Berk
    Citation: BMC Medicine 2013 11:128
  2. After 30 years of consensus-derived diagnostic categories in mental health, it is time to head in new directions. Those categories placed great emphasis on enhanced reliability and the capacity to identify the...

    Authors: Ian B Hickie, Jan Scott, Daniel F Hermens, Elizabeth M Scott, Sharon L Naismith, Adam J Guastella, Nick Glozier and Patrick D McGorry
    Citation: BMC Medicine 2013 11:125
  3. A precise understanding of the genomic and epigenomic features of chronic lymphocytic leukemia (CLL) may benefit the study of the disease’s staging and treatment. While recent reports have shed some light on t...

    Authors: Víctor Quesada, Andrew J Ramsay, David Rodríguez, Xose S Puente, Elías Campo and Carlos López-Otín
    Citation: BMC Medicine 2013 11:124
  4. The role of drug-eluting balloons (DEB) is unclear. Increasing evidence has shown a benefit for the treatment of in-stent restenosis. Its effect on de novo coronary lesions is more controversial. Several smaller ...

    Authors: Georg M Fröhlich, Alexandra J Lansky, Dennis T Ko, Olga Archangelidi, Rodney De Palma, Adam Timmis and Pascal Meier
    Citation: BMC Medicine 2013 11:123
  5. Almost nothing is known about the medical aspects of runners doing a transcontinental ultramarathon over several weeks. The results of differentiated measurements of changes in body composition during the Tran...

    Authors: Uwe HW Schütz, Christian Billich, Kathrin König, Christian Würslin, Heike Wiedelbach, Hans-Jürgen Brambs and Jürgen Machann
    Citation: BMC Medicine 2013 11:122
  6. An ancillary finding in previous research has suggested that the use of antidepressant medications increases the risk of developing Clostridium difficile infection (CDI). Our objective was to evaluate whether dep...

    Authors: Mary AM Rogers, M Todd Greene, Vincent B Young, Sanjay Saint, Kenneth M Langa, John Y Kao and David M Aronoff
    Citation: BMC Medicine 2013 11:121
  7. Atherosclerosis, the major cause of cardiovascular disease (CVD), is a chronic inflammatory condition with immune competent cells in lesions producing mainly pro-inflammatory cytokines. Dead cells and oxidized...

    Authors: Johan Frostegård
    Citation: BMC Medicine 2013 11:117
  8. The cost-effectiveness of universal rotavirus (RV) vaccination is controversial in developed countries. As a result, RV vaccination programs do not currently exist in most European countries. Hospitalization i...

    Authors: Patricia Bruijning-Verhagen, Marie-Josée J Mangen, Mariet Felderhof, Nico G Hartwig, Marlies van Houten, Léon Winkel, Wouter J de Waal and Marc JM Bonten
    Citation: BMC Medicine 2013 11:112
  9. Despite being a core business of medicine, end of life care (EoLC) is neglected. It is hampered by research that is difficult to conduct with no common standards. We aimed to develop evidence-based guidance on...

    Authors: Irene J Higginson, Catherine J Evans, Gunn Grande, Nancy Preston, Myfanwy Morgan, Paul McCrone, Penney Lewis, Peter Fayers, Richard Harding, Matthew Hotopf, Scott A Murray, Hamid Benalia, Marjolein Gysels, Morag Farquhar and Chris Todd
    Citation: BMC Medicine 2013 11:111
  10. The mind-body nexus has been a topic of growing interest. Further data are however required to understand the specific relationship between mood and anxiety disorders and individual physical health conditions,...

    Authors: Livia Sanna, Amanda L Stuart, Julie A Pasco, Mark A Kotowicz, Michael Berk, Paolo Girardi, Sharon L Brennan and Lana J Williams
    Citation: BMC Medicine 2013 11:110
  11. Neurofibromatosis type 1 (NF1) is a hereditary tumor syndrome characterized by the development of benign nerve-sheath tumors, which transform to malignant peripheral nerve-sheath tumors (MPNST) in about 8 to 1...

    Authors: Su-Jin Park, Birgit Sawitzki, Lan Kluwe, Victor F Mautner, Nikola Holtkamp and Andreas Kurtz
    Citation: BMC Medicine 2013 11:109
  12. Testosterone therapy is increasingly promoted. No randomized placebo-controlled trial has been implemented to assess the effect of testosterone therapy on cardiovascular events, although very high levels of an...

    Authors: Lin Xu, Guy Freeman, Benjamin J Cowling and C Mary Schooling
    Citation: BMC Medicine 2013 11:108
  13. Several factors contribute to the high mortality attributed to severe infections in resource-limited settings. While improvements in survival and processes of care have been made in high-income settings among ...

    Authors: Shevin T Jacob, Matthew Lim, Patrick Banura, Satish Bhagwanjee, Julian Bion, Allen C Cheng, Hillary Cohen, Jeremy Farrar, Sandy Gove, Philip Hopewell, Christopher C Moore, Cathy Roth and T Eoin West
    Citation: BMC Medicine 2013 11:107
  14. Chemosensitivity and tumor metastasis are two primary issues in cancer management. Cancer cells often exhibit a wide range of sensitivity to anti-cancer compounds. To gain insight on the genetic mechanism of d...

    Authors: Yi-Chiung Hsu, Hsuan-Yu Chen, Shinsheng Yuan, Sung-Liang Yu, Chia-Hung Lin, Guani Wu, Pan-Chyr Yang and Ker-Chau Li
    Citation: BMC Medicine 2013 11:106
  15. Patients with dementia frequently do not receive adequate palliative care which may relate to poor understanding of the natural course of dementia. We hypothesized that understanding that dementia is a progres...

    Authors: Jenny T van der Steen, Bregje D Onwuteaka-Philipsen, Dirk L Knol, Miel W Ribbe and Luc Deliens
    Citation: BMC Medicine 2013 11:105
  16. The purpose of this article is to review the imaging techniques that have changed and are anticipated to change bladder cancer evaluation. The use of multidetector 64-slice computed tomography (CT) and magneti...

    Authors: Shaista Hafeez and Robert Huddart
    Citation: BMC Medicine 2013 11:104
  17. Current policies encourage healthcare institutions to acquire clinical information systems (CIS) so that captured data can be used for secondary purposes, including clinical process improvement. Such policies ...

    Authors: Cecily Morrison, Matthew Jones, Rachel Jones and Alain Vuylsteke
    Citation: BMC Medicine 2013 11:103
  18. Surgeons are usually exposed to high workloads leading to fatigue and stress. This not only increases the likelihood of mistakes during surgery but also puts pressure on surgeons to use drugs to counteract fat...

    Authors: Andreas G Franke, Christiana Bagusat, Pavel Dietz, Isabell Hoffmann, Perikles Simon, Rolf Ulrich and Klaus Lieb
    Citation: BMC Medicine 2013 11:102
  19. Almost 25 years ago, the concept of the ‘mosaic of autoimmunity’ was introduced to the scientific community, and since then this concept has continuously evolved, with new pebbles being added regularly. We are...

    Authors: Carlo Perricone, Nancy Agmon-Levin and Yehuda Shoenfeld
    Citation: BMC Medicine 2013 11:101
  20. Long-term biodistribution of nanomaterials used in medicine is largely unknown. This is the case for alum, the most widely used vaccine adjuvant, which is a nanocrystalline compound spontaneously forming micro...

    Authors: Zakir Khan, Christophe Combadière, François-Jérôme Authier, Valérie Itier, François Lux, Christopher Exley, Meriem Mahrouf-Yorgov, Xavier Decrouy, Philippe Moretto, Olivier Tillement, Romain K Gherardi and Josette Cadusseau
    Citation: BMC Medicine 2013 11:99
  21. This study was devised to assess the performance of anti-ribosomal P (anti-Rib-P) antibodies in the diagnosis of systemic lupus erythematosus (SLE) and the association of these antibodies with the clinical fea...

    Authors: Diana Carmona-Fernandes, Maria José Santos, Helena Canhão and João Eurico Fonseca
    Citation: BMC Medicine 2013 11:98
  22. Advancements in phosphodiesterase (PDE)-targeted therapies have shown promise in recent years for treating patients with a variety of autoimmune diseases. This review summarizes the development of PDE4 inhibit...

    Authors: Neal Kumar, Ari M Goldminz, Noori Kim and Alice B Gottlieb
    Citation: BMC Medicine 2013 11:96
  23. Connective tissue diseases (CTDs) are a heterogeneous group of disorders that share certain clinical presentations and a disturbed immunoregulation, leading to autoantibody production. Subclinical or overt ren...

    Authors: Andreas Kronbichler and Gert Mayer
    Citation: BMC Medicine 2013 11:95
  24. Older persons have higher autoimmunity but a lower prevalence of autoimmune diseases. A possible explanation for this is the expansion of many protective regulatory mechanisms highly characteristic in the elde...

    Authors: Zahava Vadasz, Tharwat Haj, Aharon Kessel and Elias Toubi
    Citation: BMC Medicine 2013 11:94
  25. Sjögren’s syndrome (SS) is a systemic progressive autoimmune disease characterized by a complex pathogenesis requiring a predisposing genetic background and involving immune cell activation and autoantibody pr...

    Authors: Angela Tincani, Laura Andreoli, Ilaria Cavazzana, Andrea Doria, Marta Favero, Maria-Giulia Fenini, Franco Franceschini, Andrea Lojacono, Giuseppe Nascimbeni, Amerigo Santoro, Francesco Semeraro, Paola Toniati and Yehuda Shoenfeld
    Citation: BMC Medicine 2013 11:93
  26. We investigated interactions between genetically and autoimmune-mediated coagulopathies by inducing experimental antiphospholipid syndrome (eAPS) in mice carrying the factor V Leiden (FVL) mutation.

    Authors: Aviva Katzav, Nikolaos C Grigoriadis, Tania Ebert, Olga Touloumi, Miri Blank, Chaim G Pick, Yehuda Shoenfeld and Joab Chapman
    Citation: BMC Medicine 2013 11:92
  27. The 16/6-idiotype (16/6-Id) of the human anti-DNA antibody was found to induce experimental lupus in naïve mice, manifested by production of autoantibodies, leukopenia and elevated inflammatory markers, as wel...

    Authors: Shaye Kivity, Aviva Katzav, Maria Teresa Arango, Moran Landau-Rabi, Yaron Zafrir, Nancy Agmon-Levin, Miri Blank, Juan-Manuel Anaya, Edna Mozes, Joab Chapman and Yehuda Shoenfeld
    Citation: BMC Medicine 2013 11:90
  28. Celiac disease is a life-long autoimmune condition, affecting genetically susceptible individuals that may present with thromboembolic phenomena. This thrombophilia represents a puzzle with multiple constituen...

    Authors: Aaron Lerner, Nancy Agmon-Levin, Yinon Shapira, Boris Gilburd, Sandra Reuter, Idit Lavi and Yehuda Shoenfeld
    Citation: BMC Medicine 2013 11:89
  29. Biologic therapies for rheumatologic diseases, which are targeted at molecules involved in the mechanisms of the immune system, provide an alternative to the existing treatment methods of disease-modifying ant...

    Authors: Ziv Rosman, Yehuda Shoenfeld and Gisele Zandman-Goddard
    Citation: BMC Medicine 2013 11:88
  30. A high body mass index (BMI) is associated with an increased risk of mortality from coronary heart disease (CHD); however, a low BMI may also be associated with an increased mortality risk. There is limited in...

    Authors: Dexter Canoy, Benjamin J Cairns, Angela Balkwill, F Lucy Wright, Jane Green, Gillian Reeves and Valerie Beral
    Citation: BMC Medicine 2013 11:87
  31. Calcium deficiency is a global public-health problem. Although the initial stage of calcium deficiency can lead to metabolic alterations or potential pathological changes, calcium deficiency is difficult to di...

    Authors: Maoqing Wang, Xue Yang, Fan Wang, Ran Li, Hua Ning, Lixin Na, Yifan Huang, Yue Song, Liyan Liu, Hongzhi Pan, Qiuju Zhang, Lijun Fan, Ying Li and Changhao Sun
    Citation: BMC Medicine 2013 11:86
  32. Despite over 40 years of research, there is no specific lung-directed therapy for the acute respiratory distress syndrome (ARDS). Although much has evolved in our understanding of its pathogenesis and factors ...

    Authors: Eddy Fan, Jesus Villar and Arthur S Slutsky
    Citation: BMC Medicine 2013 11:85
  33. Multiple-arm randomized trials can be more complex in their design, data analysis, and result reporting than two-arm trials. We conducted a systematic review to assess the reporting of analyses in reports of r...

    Authors: Gabriel Baron, Elodie Perrodeau, Isabelle Boutron and Philippe Ravaud
    Citation: BMC Medicine 2013 11:84
  34. Diuretics are among the most commonly prescribed medications and, due to their mechanisms of action, electrolyte disorders are common side effects of their use. In the present work we investigated the associat...

    Authors: Spyridon Arampatzis, Georg-Christian Funk, Alexander Benedikt Leichtle, Georg-Martin Fiedler, Christoph Schwarz, Heinz Zimmermann, Aristomenis Konstantinos Exadaktylos and Gregor Lindner
    Citation: BMC Medicine 2013 11:83
  35. Currently available therapies for Alzheimer's disease (AD) do not treat the underlying cause of AD. Anecdotal observations in nursing homes from multiple studies strongly suggest an inverse relationship betwee...

    Authors: Crystal D Hayes, Debleena Dey, Juan Pablo Palavicini, Hongjie Wang, Kshitij A Patkar, Dimitriy Minond, Adel Nefzi and Madepalli K Lakshmana
    Citation: BMC Medicine 2013 11:81
  36. Economic evaluations of health interventions pose a particular challenge for reporting. There is also a need to consolidate and update existing guidelines and promote their use in a user friendly manner. The C...

    Authors: Don Husereau, Michael Drummond, Stavros Petrou, Chris Carswell, David Moher, Dan Greenberg, Federico Augustovski, Andrew H Briggs, Josephine Mauskopf and Elizabeth Loder
    Citation: BMC Medicine 2013 11:80