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  1. Patients with multimorbidity are frequent users of healthcare, but fragmented care may lead to suboptimal treatment. Yet, this has never been examined across healthcare sectors on a national scale. We aimed to...

    Authors: Anders Prior, Claus Høstrup Vestergaard, Peter Vedsted, Susan M. Smith, Line Flytkjær Virgilsen, Linda Aagaard Rasmussen and Morten Fenger-Grøn
    Citation: BMC Medicine 2023 21:305
  2. Diabetic retinopathy (DR) is a major sight-threatening microvascular complication in individuals with diabetes. Systemic inflammation combined with oxidative stress is thought to capture most of the complexiti...

    Authors: Aravind Lathika Rajendrakumar, Simona M. Hapca, Anand Thakarakkattil Narayanan Nair, Yu Huang, Mehul Kumar Chourasia, Ryan Shun-Yuen Kwan, Charvi Nangia, Moneeza K. Siddiqui, Prathiba Vijayaraghavan, Shona Z. Matthew, Graham P. Leese, Viswanathan Mohan, Ewan R. Pearson, Alexander S. F. Doney and Colin N. A. Palmer
    Citation: BMC Medicine 2023 21:304
  3. Children and young people’s (CYP) mental health is worsening, and an increasing number are seeking psychiatric and mental health care. Whilst many CYPs with low-to-medium levels of psychiatric distress can be ...

    Authors: Eleanor Keiller, Saba Masood, Ben Hoi-ching Wong, Cerian Avent, Kofi Bediako, Rebecca Margaret Bird, Isabel Boege, Marta Casanovas, Veronika Beatrice Dobler, Maya James, Jane Kiernan, Maria Martinez-Herves, Thinh Vinh Thanh Ngo, Ana Pascual-Sanchez, Izabela Pilecka, Paul L Plener…
    Citation: BMC Medicine 2023 21:303
  4. The results of human observational studies on the correlation between gut microbiota perturbations and polycystic ovary syndrome (PCOS) have been contradictory. This study aimed to perform the first systematic...

    Authors: Pan Li, Ping Shuai, Sj Shen, Huimin Zheng, Ping Sun, Renfang Zhang, Shanwei Lan, Zixin Lan, Thisun Jayawardana, Yumei Yang, Jianhui Zhao, Yuping Liu, Xia Chen, Emad M. El-Omar and Zhengwei Wan
    Citation: BMC Medicine 2023 21:302
  5. We recently published an article in BMC Medicine looking at the potential health and economic impact of paediatric vaccination using next-generation influenza vaccines in Kenya: a modelling study. In their commen...

    Authors: Naomi R. Waterlow, Simon R. Procter, Rosalind M. Eggo and Mark Jit
    Citation: BMC Medicine 2023 21:301

    The original article was published in BMC Medicine 2023 21:273

    The Research article to this article has been published in BMC Medicine 2023 21:106

  6. Patients with human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer and primary resistance to trastuzumab have a poor clinical outcome and lack good evidence to inform clinical decisi...

    Authors: Jun Cao, Yuee Teng, Huiping Li, Lili Zhang, Quchang Ouyang, Weimin Xie, Yueyin Pan, Zhenchuan Song, Xiaoling Ling, Xiaohong Wu, Jingwei Xu, Li Li, Liping Ren, Hong Wang, Dongxian Zhou, Jing Luo…
    Citation: BMC Medicine 2023 21:300
  7. Tuberous sclerosis complex (TSC) is a rare and complex genetic disorder, associated with tumor growth in various organ systems, epilepsy, and a range of neuropsychiatric manifestations including intellectual d...

    Authors: Annelieke R. Müller, Michiel A. J. Luijten, Lotte Haverman, Wendela L. de Ranitz-Greven, Peter Janssens, André B. Rietman, Leontine W. ten Hoopen, Laura C. G. de Graaff, Marie-Claire de Wit, Anna C. Jansen, Tanjala Gipson, Jamie K. Capal, Petrus J. de Vries and Agnies M. van Eeghen
    Citation: BMC Medicine 2023 21:298

    The Correction to this article has been published in BMC Medicine 2023 21:401

  8. The relationship between adverse childhood experiences (ACEs) and adverse adulthood experiences (AAEs) and their association with incident cardiovascular disease (CVD) have not been extensively studied. Consid...

    Authors: Wanxin Wang, Yifeng Liu, Yuwei Yang, Weiqing Jiang, Yanyan Ni, Xue Han, Ciyong Lu and Lan Guo
    Citation: BMC Medicine 2023 21:297
  9. Caffeine exposure modifies the turnover of monoamine neurotransmitters, which play a role in several neuropsychiatric disorders. We conducted a Mendelian randomization study to investigate whether higher plasm...

    Authors: Benjamin Woolf, Héléne T. Cronjé, Loukas Zagkos, Stephen Burgess, Dipender Gill and Susanna C. Larsson
    Citation: BMC Medicine 2023 21:296
  10. Cholangiocarcinoma (CCA) is a highly aggressive malignant tumor, and its diagnosis is still a challenge. This study aimed to identify a novel bile marker for CCA diagnosis based on proteomics and establish a d...

    Authors: Long Gao, Yanyan Lin, Ping Yue, Shuyan Li, Yong Zhang, Ningning Mi, Mingzhen Bai, Wenkang Fu, Zhili Xia, Ningzu Jiang, Jie Cao, Man Yang, Yanni Ma, Fanxiang Zhang, Chao Zhang, Joseph W. Leung…
    Citation: BMC Medicine 2023 21:294

    The Correction to this article has been published in BMC Medicine 2023 21:368

  11. Exercise training is beneficial in enhancing physical function and quality of life in cancer patients. Its comprehensive implementation remains challenging, and underlying cardiopulmonary adaptations are poorl...

    Authors: Roberto Falz, Christian Bischoff, René Thieme, Uwe Tegtbur, Peter Hillemanns, Jens-Uwe Stolzenburg, Bahriye Aktas, Ulrich Bork, Jürgen Weitz, Johannes Lässing, Christian Leps, Johannes Voß, Florian Lordick, Antina Schulze, Ines Gockel and Martin Busse
    Citation: BMC Medicine 2023 21:293
  12. Folic acid (FA) supplementation is associated with a lower risk of the neural tube and heart defects and is recommended for women of childbearing age. Although there are detailed recommendations, differences i...

    Authors: Jing Dong, Lin-Liang Yin, Xue-Dong Deng, Chun-Ya Ji, Qi Pan, Zhong Yang, Ting Peng and Jiang-Nan Wu
    Citation: BMC Medicine 2023 21:292
  13. Comorbidity is the rule rather than the exception for childhood and adolescent onset mental disorders, but we cannot predict its occurrence and do not know the neural mechanisms underlying comorbidity. We inve...

    Authors: Nanyu Kuang, Zhaowen Liu, Gechang Yu, Xinran Wu, Benjamin Becker, Huaxin Fan, Songjun Peng, Kai Zhang, Jiajia Zhao, Jujiao Kang, Guiying Dong, Xingming Zhao, Barbara J. Sahakian, Trevor W. Robbins, Wei Cheng, Jianfeng Feng…
    Citation: BMC Medicine 2023 21:291
  14. The current guidelines for survivorship in adolescents and young adults (AYA) cancer are based on studies conducted in the United States and European AYA survivors. However, previous studies have shown that th...

    Authors: Sooyeon Kim, Juhee Cho, Dong Wook Shin, Su-Min Jeong and Danbee Kang
    Citation: BMC Medicine 2023 21:289
  15. India had an estimated 2.9 million tuberculosis cases and 506 thousand deaths in 2021. Novel vaccines effective in adolescents and adults could reduce this burden. M72/AS01E and BCG-revaccination have recently co...

    Authors: Rebecca A. Clark, Chathika K. Weerasuriya, Allison Portnoy, Christinah Mukandavire, Matthew Quaife, Roel Bakker, Danny Scarponi, Rebecca C. Harris, Kirankumar Rade, Sanjay Kumar Mattoo, Dheeraj Tumu, Nicolas A. Menzies and Richard G. White
    Citation: BMC Medicine 2023 21:288
  16. Disrupted intestinal epithelial barrier is one of the major causes of Crohn’s disease (CD). Novel molecular targets for intestinal epithelial barrier are essential to treatment of CD. Transmembrane and immunog...

    Authors: Longyuan Zhou, Liguo Zhu, Xiaomin Wu, Shixian Hu, Shenghong Zhang, Min Ning, Jun Yu and Minhu Chen
    Citation: BMC Medicine 2023 21:287
  17. Microglia are known to regulate stress and anxiety in both humans and animal models. Psychosocial stress is the most common risk factor for the development of schizophrenia. However, how microglia/brain macrop...

    Authors: Ling Yan, Yanli Li, Fengmei Fan, Mengzhuang Gou, Fangling Xuan, Wei Feng, Keerthana Chithanathan, Wei Li, Junchao Huang, Hongna Li, Wenjin Chen, Baopeng Tian, Zhiren Wang, Shuping Tan, Alexander Zharkovsky, L. Elliot Hong…
    Citation: BMC Medicine 2023 21:286
  18. Psoriasis and atopic eczema are common inflammatory skin diseases. Existing research has identified increased risks of common mental disorders (anxiety, depression) in people with eczema and psoriasis; however...

    Authors: Alasdair D. Henderson, Elizabeth Adesanya, Amy Mulick, Julian Matthewman, Nhung Vu, Firoza Davies, Catherine H. Smith, Joseph Hayes, Kathryn E. Mansfield and Sinéad M. Langan
    Citation: BMC Medicine 2023 21:285
  19. Tinnitus affects 10 to 15% of the population, but its underlying causes are not yet fully understood. Hearing loss has been established as the most important risk factor. Ageing is also known to accompany incr...

    Authors: Lisa Reisinger, Fabian Schmidt, Kaja Benz, Lorenzo Vignali, Sebastian Roesch, Martin Kronbichler and Nathan Weisz
    Citation: BMC Medicine 2023 21:283
  20. Self-harm is an important predictor of a suicide death. Culturally appropriate strategies for the prevention of self-harm and suicide are needed but the evidence is very limited from low- and middle-income cou...

    Authors: Nusrat Husain, Tayyeba Kiran, Imran Bashir Chaudhry, Christopher Williams, Richard Emsley, Usman Arshad, Moin Ahmed Ansari, Paul Bassett, Penny Bee, Moti Ram Bhatia, Carolyn Chew-Graham, Muhammad Omair Husain, Muhammad Irfan, Ayesha Khaliq, Fareed A. Minhas, Farooq Naeem…
    Citation: BMC Medicine 2023 21:282
  21. The EAT-Lancet Commission proposed a global reference diet with both human health benefits and environmental sustainability in 2019. However, evidence regarding the association of such a diet with the risk of ...

    Authors: Shunming Zhang, Anna Stubbendorff, Ulrika Ericson, Per Wändell, Kaijun Niu, Lu Qi, Yan Borné and Emily Sonestedt
    Citation: BMC Medicine 2023 21:280
  22. HCV self-testing (HCVST) may be an effective strategy to address low rates of HCV test uptake among men who have sex with men (MSM). We evaluated the effectiveness and cost of providing HCVST to increase HCV t...

    Authors: Cheng Wang, Peizhen Zhao, Ann Marie Weideman, Wenqian Xu, Jason J. Ong, Muhammad S. Jamil, Bin Yang and Joseph D. Tucker
    Citation: BMC Medicine 2023 21:279
  23. Meat-free diets may be associated with a higher risk of hip fracture, but prospective evidence is limited. We aimed to investigate the risk of hip fracture in occasional meat-eaters, pescatarians, and vegetari...

    Authors: James Webster, Darren C. Greenwood and Janet E. Cade
    Citation: BMC Medicine 2023 21:278
  24. China has one of the highest numbers of liver disease cases in the world, including 6.4 million cirrhosis associated with alcohol-related liver disease (ALD) cases. However, there is still a lack of urgent awa...

    Authors: Meiyu Wu, Shuxia Qin, Chongqing Tan, Sini Li, Ouyang Xie and Xiaomin Wan
    Citation: BMC Medicine 2023 21:277
  25. Homozygous familial hypercholesterolemia (HoFH) is an orphan metabolic disease characterized by extremely elevated low-density lipoprotein cholesterol (LDL-C), xanthomas, aortic stenosis, and premature atheros...

    Authors: Zhiyong Du, Fan Li, Long Jiang, Linyi Li, Yunhui Du, Huahui Yu, Yan Luo, Yu Wang, Haili Sun, Chaowei Hu, Jianping Li, Ya Yang, Xiaolu Jiao, Luya Wang and Yanwen Qin
    Citation: BMC Medicine 2023 21:275
  26. Persistent infection by oncogenic human papillomavirus (HPV) is necessary although not sufficient for development of cervical cancer. Behavioural, environmental, or comorbid exposures may promote or protect ag...

    Authors: Sarah J. Bowden, Triada Doulgeraki, Emmanouil Bouras, Georgios Markozannes, Antonios Athanasiou, Harriet Grout-Smith, Konstantinos S. Kechagias, Laura Burney Ellis, Verena Zuber, Marc Chadeau-Hyam, James M. Flanagan, Konstantinos K. Tsilidis, Ilkka Kalliala and Maria Kyrgiou
    Citation: BMC Medicine 2023 21:274
  27. In the dynamic landscape of respiratory virus vaccines, it is crucial to assess the value of novel mRNA and combination influenza/COVID-19 vaccines in low- and middle-income countries. Modeling studies, such a...

    Authors: K. E. Lafond, R. Gharpure, V. G. Dugan and E. Azziz-Baumgartner
    Citation: BMC Medicine 2023 21:273

    The Correspondence to this article has been published in BMC Medicine 2023 21:301

    The original article was published in BMC Medicine 2023 21:106

  28. Coffee is the most widely consumed psychostimulant worldwide. Emerging evidence indicates that coffee consumption habit significantly reduces the risk of developing Parkinson’s disease (PD). However, the effec...

    Authors: Chao Wang, Cheng Zhou, Tao Guo, Yeerfan Jiaerken, Siyu Yang, Xiaopei Xu, Ling Hu, Peiyu Huang, Xiaojun Xu and Minming Zhang
    Citation: BMC Medicine 2023 21:272
  29. Stroke is a major cause of mortality and long-term disability worldwide. Whether the associations between brain imaging-derived phenotypes (IDPs) and stroke are causal is uncertain.

    Authors: Ke Yu, Xiao-Feng Chen, Jing Guo, Sen Wang, Xiao-Ting Huang, Yan Guo, Shan-Shan Dong and Tie-Lin Yang
    Citation: BMC Medicine 2023 21:271
  30. The introduction of multiparameter MRI and novel biomarkers has greatly improved the prediction of clinically significant prostate cancer (csPCa). However, decision-making regarding prostate biopsy and prebiop...

    Authors: Huiyong Zhang, Jin Ji, Zhe Liu, Huiru Lu, Chong Qian, Chunmeng Wei, Shaohua Chen, Wenhao Lu, Chengbang Wang, Huan Xu, Yalong Xu, Xi Chen, Xing He, Zuheng Wang, Xiaodong Zhao, Wen Cheng…
    Citation: BMC Medicine 2023 21:270
  31. Chronic disease management (CDM) through sustained knowledge translation (KT) interventions ensures long-term, high-quality care. We assessed implementation of KT interventions for supporting CDM and their eff...

    Authors: Areti Angeliki Veroniki, Charlene Soobiah, Vera Nincic, Yonda Lai, Patricia Rios, Heather MacDonald, Paul A. Khan, Marco Ghassemi, Fatemeh Yazdi, Ross C. Brownson, David A. Chambers, Lisa R. Dolovich, Annemarie Edwards, Paul P. Glasziou, Ian D. Graham, Brenda R. Hemmelgarn…
    Citation: BMC Medicine 2023 21:269

    The Commentary to this article has been published in BMC Medicine 2023 21:325

  32. Tumour-infiltrating lymphocytes (TILs), including T and B cells, have been demonstrated to be associated with tumour progression. However, the different subpopulations of TILs and their roles in breast cancer ...

    Authors: Zi-An Xia, Can Lu, Can Pan, Jia Li, Jun Li, Yitao Mao, Lunquan Sun and Jiang He
    Citation: BMC Medicine 2023 21:268
  33. Comorbidities are expected to impact the pathophysiology of heart failure (HF) with preserved ejection fraction (HFpEF). However, comorbidity profiles are usually reduced to a few comorbid disorders. Systems m...

    Authors: Jan D. Lanzer, Alberto Valdeolivas, Mark Pepin, Hauke Hund, Johannes Backs, Norbert Frey, Hans-Christoph Friederich, Jobst-Hendrik Schultz, Julio Saez-Rodriguez and Rebecca T. Levinson
    Citation: BMC Medicine 2023 21:267
  34. Increasing evidence suggests an association between pro-inflammatory diets and cognitive function. However, only a few studies based on small sample sizes have explored the association between pro-inflammatory...

    Authors: Yisen Shi, Fabin Lin, Yueping Li, Yingqing Wang, Xiaochun Chen, Fangang Meng, Qinyong Ye and Guoen Cai
    Citation: BMC Medicine 2023 21:266
  35. Prehabilitation aims at enhancing patients’ functional capacity and overall health status to enable them to withstand a forthcoming stressor like surgery. Our aim was to synthesise the evidence on the cost-eff...

    Authors: Tanja Rombey, Helene Eckhardt, Jörn Kiselev, Julia Silzle, Tim Mathes and Wilm Quentin
    Citation: BMC Medicine 2023 21:265
  36. Since the coronavirus disease 2019 (COVID-19) outbreak, many COVID-19 variants have emerged, causing several waves of pandemics and many infections. Long COVID-19, or long-term sequelae after recovery from COV...

    Authors: Deyu Zhang, Siyuan Weng, Chuanchao Xia, Yuqing Ren, Zaoqu Liu, Yudi Xu, Xiaoli Yang, Ruhao Wu, Lisi Peng, Liqi Sun, Jiaqi Zhu, Xuesong Liang, Yin Jia, Huaizhou Wang, Qian Chen, Dongtian Liu…
    Citation: BMC Medicine 2023 21:264
  37. It remains a challenge to predict the long-term response to antipsychotics in patients with schizophrenia who do not respond at an early stage. This study aimed to investigate the optimal predictive cut-off va...

    Authors: Yujun Long, Qiongqiong Wu, Ye Yang, Jingda Cai, Jingmei Xiao, Zhaoqian Liu, Yifeng Xu, Ying Chen, Manli Huang, Ruiguo Zhang, Xijia Xu, Jian Hu, Zhifen Liu, Fang Liu, Yingjun Zheng, Huaqing Meng…
    Citation: BMC Medicine 2023 21:263
  38. Probiotics are often used to prevent antibiotic-induced low-diversity dysbiosis, however their effect is not yet sufficiently summarized in this regard. We aimed to investigate the effects of concurrent probio...

    Authors: Anna Júlia Éliás, Viktória Barna, Cristina Patoni, Dóra Demeter, Dániel Sándor Veres, Stefania Bunduc, Bálint Erőss, Péter Hegyi, László Földvári-Nagy and Katalin Lenti
    Citation: BMC Medicine 2023 21:262
  39. Previous studies have found a correlation between coronavirus disease 2019 (COVID-19) and changes in brain structure and cognitive function, but it remains unclear whether COVID-19 causes brain structural chan...

    Authors: Shaojiong Zhou, Tao Wei, Xiaoduo Liu, Yufei Liu, Weiyi Song, Xinwei Que, Yi Xing, Zhibin Wang and Yi Tang
    Citation: BMC Medicine 2023 21:261
  40. Gestational diabetes mellitus (GDM) is associated with both short- and long-term risks, although it is unknown if risks vary by severity, timing, and duration of gestational hyperglycemia. We aimed to identify...

    Authors: Shuyun Chen, Margareta Persson, Rui Wang, Christina Dalman, Brian K. Lee, HÃ¥kan Karlsson and Renee M. Gardner
    Citation: BMC Medicine 2023 21:260
  41. To determine the extent and nature of changes associated with COVID-19 infection in terms of healthcare utilisation, this study observed healthcare contact 1 to 4 and 5 to 24 weeks following a COVID-19 diagnos...

    Authors: J Kennedy, M Parker, M Seaborne, M Mhereeg, A Walker, V Walker, S Denaxas, N Kennedy, S. V Katikireddi and S Brophy
    Citation: BMC Medicine 2023 21:259
  42. Preterm birth (PTB), defined as delivery before 37 gestational weeks, imposes significant public health burdens. A recent maternal genome-wide association study of spontaneous PTB identified a noncoding locus ...

    Authors: Li Wang, Robert M. Rossi, Xiaoting Chen, Jing Chen, Jilian Runyon, Mehak Chawla, Daniel Miller, Carmy Forney, Arthur Lynch, Xuzhe Zhang, Fansheng Kong, Bo Jacobsson, Leah C. Kottyan, Matthew T. Weirauch, Ge Zhang and Louis J. Muglia
    Citation: BMC Medicine 2023 21:258
  43. Valvular heart disease (VHD) can cause damage to extra-cardiac organs, and lead to multi-organ dysfunction. However, little is known about the cardio-renal-hepatic co-dysfunction, as well as its prognostic imp...

    Authors: Junxing Lv, Bin Zhang, Yunqing Ye, Zhe Li, Weiwei Wang, Qinghao Zhao, Qingrong Liu, Zhenyan Zhao, Haitong Zhang, Bincheng Wang, Zikai Yu, Zhenya Duan, Shuai Guo, Yanyan Zhao, Runlin Gao, Haiyan Xu…
    Citation: BMC Medicine 2023 21:257
  44. Genome-wide association studies (GWAS) have reported single-nucleotide polymorphisms (SNPs) in the VRK serine/threonine kinase 2 gene (VRK2) showing genome-wide significant associations with major depression, but...

    Authors: Mei-Yu Yin, Lei Guo, Li-Juan Zhao, Chen Zhang, Wei-Peng Liu, Chu-Yi Zhang, Jin-Hua Huo, Lu Wang, Shi-Wu Li, Chang-Bo Zheng, Xiao Xiao, Ming Li, Chuang Wang and Hong Chang
    Citation: BMC Medicine 2023 21:256
  45. The feasibility of DNA methylation-based assays in detecting minimal residual disease (MRD) and postoperative monitoring remains unestablished. We aim to investigate the dynamic characteristics of cancer-relat...

    Authors: Kezhong Chen, Guannan Kang, Zhihong Zhang, Analyn Lizaso, Stephan Beck, Iben Lyskjær, Olga Chervova, Bingsi Li, Haifeng Shen, Chenyang Wang, Bing Li, Heng Zhao, Xi Li, Fan Yang, Nnennaya Kanu and Jun Wang
    Citation: BMC Medicine 2023 21:255