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  1. Preeclampsia (PE) is a pregnancy-related vascular disorder which is the leading cause of maternal morbidity and mortality. We sought to identify novel serological protein markers to diagnose PE with a multi-’o...

    Authors: Linda Y Liu, Ting Yang, Jun Ji, Qiaojun Wen, Alexander A Morgan, Bo Jin, Gongxing Chen, Deirdre J Lyell, David K Stevenson, Xuefeng B Ling and Atul J Butte
    Citation: BMC Medicine 2013 11:236
  2. The recent discovery of a new myokine (irisin) potentially involved in health-related training effects has gained great attention, but evidence for a training-induced increase in irisin remains preliminary. Th...

    Authors: Anne Hecksteden, Melissa Wegmann, Anke Steffen, Jochen Kraushaar, Arne Morsch, Sandra Ruppenthal, Lars Kaestner and Tim Meyer
    Citation: BMC Medicine 2013 11:235
  3. Reducing mortality from HIV-associated tuberculosis (TB) requires diagnostic tools that are rapid and have high sensitivity among patients with poor prognosis. We determined the relationship between disease se...

    Authors: Stephen D Lawn, Andrew D Kerkhoff, Monica Vogt and Robin Wood
    Citation: BMC Medicine 2013 11:231
  4. Antidepressants are often considered to be mere placebos despite the fact that meta-analyses are able to rank them. It follows that it should also be possible to rank different placebos, which are all made of ...

    Authors: Florian Naudet, Bruno Millet, Philippe Charlier, Jean Michel Reymann, Anne Solène Maria and Bruno Falissard
    Citation: BMC Medicine 2013 11:230
  5. Ancestral environmental exposures to a variety of environmental factors and toxicants have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. The present work examined t...

    Authors: Michael K Skinner, Mohan Manikkam, Rebecca Tracey, Carlos Guerrero-Bosagna, Muksitul Haque and Eric E Nilsson
    Citation: BMC Medicine 2013 11:228
  6. Australia was one of the first countries to introduce a publicly funded national human papillomavirus (HPV) vaccination program that commenced in April 2007, using the quadrivalent HPV vaccine targeting 12- to...

    Authors: Dorota M Gertig, Julia ML Brotherton, Alison C Budd, Kelly Drennan, Genevieve Chappell and A Marion Saville
    Citation: BMC Medicine 2013 11:227
  7. High-throughput ‘omics’ technologies that generate molecular profiles for biospecimens have been extensively used in preclinical studies to reveal molecular subtypes and elucidate the biological mechanisms of ...

    Authors: Lisa M McShane, Margaret M Cavenagh, Tracy G Lively, David A Eberhard, William L Bigbee, P Mickey Williams, Jill P Mesirov, Mei-Yin C Polley, Kelly Y Kim, James V Tricoli, Jeremy MG Taylor, Deborah J Shuman, Richard M Simon, James H Doroshow and Barbara A Conley
    Citation: BMC Medicine 2013 11:220
  8. The Millennium Development Goals have galvanized efforts to improve child survival (MDG-4) and maternal health (MDG-5). There has been important progress on both MDGs at global level, although it now appears t...

    Authors: Jennifer Bryce, Robert E Black and Cesar G Victora
    Citation: BMC Medicine 2013 11:225
  9. The most severe HIV epidemics worldwide occur in Lesotho, Botswana and Swaziland. Here we focus on the Lesotho epidemic, which has received little attention. We determined the within-country heterogeneity in t...

    Authors: Brian J Coburn, Justin T Okano and Sally Blower
    Citation: BMC Medicine 2013 11:224
  10. Global health is a varied field that comprises research, evaluation and policy that, by its definition, also occurs in disparate locations across the world. This forum article is introduced by our guest editor...

    Authors: Gretchen L Birbeck, Charles S Wiysonge, Edward J Mills, Julio J Frenk, Xiao-Nong Zhou and Prabhat Jha
    Citation: BMC Medicine 2013 11:223
  11. Herbal products available to consumers in the marketplace may be contaminated or substituted with alternative plant species and fillers that are not listed on the labels. According to the World Health Organiza...

    Authors: Steven G Newmaster, Meghan Grguric, Dhivya Shanmughanandhan, Sathishkumar Ramalingam and Subramanyam Ragupathy
    Citation: BMC Medicine 2013 11:222
  12. The role of the venous system in the pathogenesis of inflammatory neurological/neurodegenerative diseases remains largely unknown and underinvestigated. Aside from cerebral venous infarcts, thromboembolic even...

    Authors: Jonathan S Alexander, Leonard Prouty, Ikuo Tsunoda, Chaitanya Vijay Ganta and Alireza Minagar
    Citation: BMC Medicine 2013 11:219
  13. The incidence of cancer increases with advanced age. And as the world populationages, clinicians will be faced with a growing number of older patients withcancer. The challenge that clinicians face involves ca...

    Authors: Maxine de la Cruz and Eduardo Bruera
    Citation: BMC Medicine 2013 11:218
  14. The development of cardiovascular dysfunction and shock in patients with invasive Bacillus anthracis infection has a particularly poor prognosis. Growing evidence indicates that several bacterial components likel...

    Authors: Kenneth E Remy, Ping Qiu, Yan Li, Xizhong Cui and Peter Q Eichacker
    Citation: BMC Medicine 2013 11:217
  15. A beneficial effect of a high n-3 long-chain polyunsaturated fatty acid (LCPUFA) intake has been observed in heart failure patients, who are frequently insulin resistant. We investigated the potential influenc...

    Authors: Elin Strand, Eva R Pedersen, Gard FT Svingen, Hall Schartum-Hansen, Eirik W Rebnord, Bodil Bjørndal, Reinhard Seifert, Pavol Bohov, Klaus Meyer, J Kalervo Hiltunen, Jan E Nordrehaug, Dennis WT Nilsen, Rolf K Berge and Ottar Nygård
    Citation: BMC Medicine 2013 11:216
  16. Fetal and neonatal mortality rates in low-income countries are at least 10-fold greater than in high-income countries. These differences have been related to poor access to and poor quality of obstetric and ne...

    Authors: Omrana Pasha, Elizabeth M McClure, Linda L Wright, Sarah Saleem, Shivaprasad S Goudar, Elwyn Chomba, Archana Patel, Fabian Esamai, Ana Garces, Fernando Althabe, Bhala Kodkany, Hillary Mabeya, Albert Manasyan, Waldemar A Carlo, Richard J Derman, Patricia L Hibberd…
    Citation: BMC Medicine 2013 11:215
  17. On 31 March 2013, the first human infections with the novel influenza A/H7N9 virus were reported in Eastern China. The outbreak expanded rapidly in geographic scope and size, with a total of 132 laboratory-con...

    Authors: Gerardo Chowell, Lone Simonsen, Sherry Towers, Mark A Miller and Cécile Viboud
    Citation: BMC Medicine 2013 11:214
  18. There are widespread concerns about communication and support for patients and families, especially when they face clinical uncertainty, a situation most marked in intensive care units (ICUs). Therefore, we ai...

    Authors: Irene J Higginson, Jonathan Koffman, Philip Hopkins, Wendy Prentice, Rachel Burman, Sara Leonard, Caroline Rumble, Jo Noble, Odette Dampier, William Bernal, Sue Hall, Myfanwy Morgan and Cathy Shipman
    Citation: BMC Medicine 2013 11:213
  19. Hypnotics are widely used by the elderly, and their impact on mortality remains controversial. The inconsistent findings could be due to methodological limitations, notably the lack of control for underlying s...

    Authors: Isabelle Jaussent, Marie-Laure Ancelin, Claudine Berr, Karine Pérès, Jacqueline Scali, Alain Besset, Karen Ritchie and Yves Dauvilliers
    Citation: BMC Medicine 2013 11:212
  20. Hypertension is one of the most important and common cardiovascular risk factors. Defining the level at which blood pressure starts causing end-organ damage is challenging, and is not easily answered. The thre...

    Authors: Pascal Meier, Franz H Messerli, Andreas Baumbach and Alexandra J Lansky
    Citation: BMC Medicine 2013 11:211
  21. This study was conducted to assess whether patient-reported outcomes (PROs) differ by the underlying diagnosis (rheumatoid arthritis (RA)/inflammatory arthritis, osteoarthritis (OA), avascular necrosis of bone...

    Authors: Jasvinder A Singh and David G Lewallen
    Citation: BMC Medicine 2013 11:210
  22. Perineal trauma during childbirth affects millions of women worldwide every year. The aim of the Perineal Assessment and Repair Longitudinal Study (PEARLS) was to improve maternal clinical outcomes following c...

    Authors: Khaled M K Ismail, Christine Kettle, Sue E Macdonald, Sue Tohill, Peter W Thomas and Debra Bick
    Citation: BMC Medicine 2013 11:209
  23. A few observational studies have found an inverse association between adherence to a Mediterranean diet and the risk of depression. Randomized trials with an intervention based on this dietary pattern could pr...

    Authors: Almudena Sánchez-Villegas, Miguel Angel Martínez-González, Ramón Estruch, Jordi Salas-Salvadó, Dolores Corella, Maria Isabel Covas, Fernando Arós, Dora Romaguera, Enrique Gómez-Gracia, José Lapetra, Xavier Pintó, Jose Alfredo Martínez, Rosa María Lamuela-Raventós, Emilio Ros, Alfredo Gea, Julia Wärnberg…
    Citation: BMC Medicine 2013 11:208
  24. Hypertension can be prevented by adopting healthy dietary patterns. Our aim was to assess the 4-year effect on blood pressure (BP) control of a randomized feeding trial promoting the traditional Mediterranean ...

    Authors: Estefania Toledo, Frank B Hu, Ramon Estruch, Pilar Buil-Cosiales, Dolores Corella, Jordi Salas-Salvadó, M Isabel Covas, Fernando Arós, Enrique Gómez-Gracia, Miquel Fiol, Jose Lapetra, Luis Serra-Majem, Xavier Pinto, Rosa M Lamuela-Raventós, Guillermo Saez, Mònica Bulló…
    Citation: BMC Medicine 2013 11:207
  25. Cholera mainly affects developing countries where safe water supply and sanitation infrastructure are often rudimentary. Sub-Saharan Africa is a cholera hotspot. Effective cholera control requires not only a p...

    Authors: Christian Schaetti, Neisha Sundaram, Sonja Merten, Said M Ali, Erick O Nyambedha, Bruno Lapika, Claire-Lise Chaignat, Raymond Hutubessy and Mitchell G Weiss
    Citation: BMC Medicine 2013 11:206
  26. ‘Encephalomyelitis disseminata’ (multiple sclerosis) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are both classified as diseases of the central nervous system by the World Health Organizati...

    Authors: Gerwyn Morris and Michael Maes
    Citation: BMC Medicine 2013 11:205
  27. In this podcast we talk to Prof Eric Taylor about the changes to the diagnosis of Attention Deficit Hyperactivity Disorder (ADHD) in DSM-5 and how these changes will affect clinical practice.

    Authors: Eric Taylor
    Citation: BMC Medicine 2013 11:204
  28. In this podcast we talk to Prof David Kupfer about the challenges, controversies and future directions of DSM-5 by considering other research frameworks and classification systems of disease, and how this revi...

    Authors: David Kupfer
    Citation: BMC Medicine 2013 11:203
  29. The recent release of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) by the American Psychiatric Association has led to much debate. For this forum article, we asked BMC Me...

    Authors: Charles B Nemeroff, Daniel Weinberger, Michael Rutter, Harriet L MacMillan, Richard A Bryant, Simon Wessely, Dan J Stein, Carmine M Pariante, Florian Seemüller, Michael Berk, Gin S Malhi, Martin Preisig, Martin Brüne and Paul Lysaker
    Citation: BMC Medicine 2013 11:202
  30. We now know that depression is associated with a chronic, low-grade inflammatory response and activation of cell-mediated immunity, as well as activation of the compensatory anti-inflammatory reflex system. It...

    Authors: Michael Berk, Lana J Williams, Felice N Jacka, Adrienne O’Neil, Julie A Pasco, Steven Moylan, Nicholas B Allen, Amanda L Stuart, Amie C Hayley, Michelle L Byrne and Michael Maes
    Citation: BMC Medicine 2013 11:200
  31. Rehabilitation interventions, including physiotherapy and occupational therapy, can improve patient outcomes; however, the optimal duration and frequency of inpatient rehabilitation interventions is uncertain....

    Authors: Ann M Parker, Robert K Lord and Dale M Needham
    Citation: BMC Medicine 2013 11:199
  32. Many inpatients receive little or no rehabilitation on weekends. Our aim was to determine what effect providing additional Saturday rehabilitation during inpatient rehabilitation had on functional independence...

    Authors: Casey L Peiris, Nora Shields, Natasha K Brusco, Jennifer J Watts and Nicholas F Taylor
    Citation: BMC Medicine 2013 11:198

    The Erratum to this article has been published in BMC Medicine 2013 11:262

  33. Clinical pathologies draw us to envisage disease as either an independent entity or a diverse set of traits governed by common physiopathological mechanisms, prompted by environmental assaults throughout life....

    Authors: John Castiblanco, Mauricio Arcos-Burgos and Juan-Manuel Anaya
    Citation: BMC Medicine 2013 11:197
  34. The clustering of metabolic and cardiovascular risk factors is known as metabolic syndrome (MetS). The risk of having MetS is strongly associated with increased adiposity and can be further modified by smoking...

    Authors: Sandra N Slagter, Jana V van Vliet-Ostaptchouk, Judith M Vonk, H Marike Boezen, Robin PF Dullaart, Anneke C Muller Kobold, Edith J Feskens, André P van Beek, Melanie M van derKlauw and Bruce HR Wolffenbuttel
    Citation: BMC Medicine 2013 11:195
  35. Clinical decision support systems assist physicians in interpreting complex patient data. However, they typically operate on a per-patient basis and do not exploit the extensive latent medical knowledge in ele...

    Authors: Assaf Gottlieb, Gideon Y Stein, Eytan Ruppin, Russ B Altman and Roded Sharan
    Citation: BMC Medicine 2013 11:194
  36. Alcoholic beverages are widely consumed. Depression, the most prevalent mental disorder worldwide, has been related to alcohol intake. We aimed to prospectively assess the association between alcohol intake an...

    Authors: Alfredo Gea, Juan J Beunza, Ramón Estruch, Almudena Sánchez-Villegas, Jordi Salas-Salvadó, Pilar Buil-Cosiales, Enrique Gómez-Gracia, María-Isabel Covas, Dolores Corella, Miquel Fiol, Fernando Arós, José Lapetra, Rosa-María Lamuela-Raventós, Julia Wärnberg, Xavier Pintó, Lluis Serra-Majem…
    Citation: BMC Medicine 2013 11:192
  37. Given the uncertainties regarding thyroid nodule assessment and management, physicians require systematically and transparently developed recommendations. This systematic review assesses the quality and consis...

    Authors: Tsai-Wei Huang, Jun-Hung Lai, Mei-Yi Wu, Shiah-Lian Chen, Chih-Hsiung Wu and Ka-Wai Tam
    Citation: BMC Medicine 2013 11:191
  38. In this article, we give an overview of new technologies for the diagnosis of tuberculosis (TB) and drug resistance, consider their advantages over existing methodologies, broad issues of cost, cost-effectiven...

    Authors: Francis Drobniewski, Vladyslav Nikolayevskyy, Horst Maxeiner, Yanina Balabanova, Nicola Casali, Irina Kontsevaya and Olga Ignatyeva
    Citation: BMC Medicine 2013 11:190
  39. Changing perspectives on the natural history of celiac disease (CD), new serology and genetic tests, and amended histological criteria for diagnosis cast doubt on past prevalence estimates for CD. We set out t...

    Authors: Robert P Anderson, Margaret J Henry, Roberta Taylor, Emma L Duncan, Patrick Danoy, Marylia J Costa, Kathryn Addison, Jason A Tye-Din, Mark A Kotowicz, Ross E Knight, Wendy Pollock, Geoffrey C Nicholson, Ban-Hock Toh, Matthew A Brown and Julie A Pasco
    Citation: BMC Medicine 2013 11:188
  40. Magnesium plays an essential role in the synthesis and metabolism of vitamin D and magnesium supplementation substantially reversed the resistance to vitamin D treatment in patients with magnesium-dependent vi...

    Authors: Xinqing Deng, Yiqing Song, JoAnn E Manson, Lisa B Signorello, Shumin M Zhang, Martha J Shrubsole, Reid M Ness, Douglas L Seidner and Qi Dai
    Citation: BMC Medicine 2013 11:187