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  1. Meat-free diets may be associated with a higher risk of hip fracture, but prospective evidence is limited. We aimed to investigate the risk of hip fracture in occasional meat-eaters, pescatarians, and vegetari...

    Authors: James Webster, Darren C. Greenwood and Janet E. Cade
    Citation: BMC Medicine 2023 21:278
  2. China has one of the highest numbers of liver disease cases in the world, including 6.4 million cirrhosis associated with alcohol-related liver disease (ALD) cases. However, there is still a lack of urgent awa...

    Authors: Meiyu Wu, Shuxia Qin, Chongqing Tan, Sini Li, Ouyang Xie and Xiaomin Wan
    Citation: BMC Medicine 2023 21:277
  3. Persistent infection by oncogenic human papillomavirus (HPV) is necessary although not sufficient for development of cervical cancer. Behavioural, environmental, or comorbid exposures may promote or protect ag...

    Authors: Sarah J. Bowden, Triada Doulgeraki, Emmanouil Bouras, Georgios Markozannes, Antonios Athanasiou, Harriet Grout-Smith, Konstantinos S. Kechagias, Laura Burney Ellis, Verena Zuber, Marc Chadeau-Hyam, James M. Flanagan, Konstantinos K. Tsilidis, Ilkka Kalliala and Maria Kyrgiou
    Citation: BMC Medicine 2023 21:274
  4. Coffee is the most widely consumed psychostimulant worldwide. Emerging evidence indicates that coffee consumption habit significantly reduces the risk of developing Parkinson’s disease (PD). However, the effec...

    Authors: Chao Wang, Cheng Zhou, Tao Guo, Yeerfan Jiaerken, Siyu Yang, Xiaopei Xu, Ling Hu, Peiyu Huang, Xiaojun Xu and Minming Zhang
    Citation: BMC Medicine 2023 21:272
  5. Stroke is a major cause of mortality and long-term disability worldwide. Whether the associations between brain imaging-derived phenotypes (IDPs) and stroke are causal is uncertain.

    Authors: Ke Yu, Xiao-Feng Chen, Jing Guo, Sen Wang, Xiao-Ting Huang, Yan Guo, Shan-Shan Dong and Tie-Lin Yang
    Citation: BMC Medicine 2023 21:271
  6. The introduction of multiparameter MRI and novel biomarkers has greatly improved the prediction of clinically significant prostate cancer (csPCa). However, decision-making regarding prostate biopsy and prebiop...

    Authors: Huiyong Zhang, Jin Ji, Zhe Liu, Huiru Lu, Chong Qian, Chunmeng Wei, Shaohua Chen, Wenhao Lu, Chengbang Wang, Huan Xu, Yalong Xu, Xi Chen, Xing He, Zuheng Wang, Xiaodong Zhao, Wen Cheng…
    Citation: BMC Medicine 2023 21:270
  7. Chronic disease management (CDM) through sustained knowledge translation (KT) interventions ensures long-term, high-quality care. We assessed implementation of KT interventions for supporting CDM and their eff...

    Authors: Areti Angeliki Veroniki, Charlene Soobiah, Vera Nincic, Yonda Lai, Patricia Rios, Heather MacDonald, Paul A. Khan, Marco Ghassemi, Fatemeh Yazdi, Ross C. Brownson, David A. Chambers, Lisa R. Dolovich, Annemarie Edwards, Paul P. Glasziou, Ian D. Graham, Brenda R. Hemmelgarn…
    Citation: BMC Medicine 2023 21:269

    The Commentary to this article has been published in BMC Medicine 2023 21:325

  8. Tumour-infiltrating lymphocytes (TILs), including T and B cells, have been demonstrated to be associated with tumour progression. However, the different subpopulations of TILs and their roles in breast cancer ...

    Authors: Zi-An Xia, Can Lu, Can Pan, Jia Li, Jun Li, Yitao Mao, Lunquan Sun and Jiang He
    Citation: BMC Medicine 2023 21:268
  9. Comorbidities are expected to impact the pathophysiology of heart failure (HF) with preserved ejection fraction (HFpEF). However, comorbidity profiles are usually reduced to a few comorbid disorders. Systems m...

    Authors: Jan D. Lanzer, Alberto Valdeolivas, Mark Pepin, Hauke Hund, Johannes Backs, Norbert Frey, Hans-Christoph Friederich, Jobst-Hendrik Schultz, Julio Saez-Rodriguez and Rebecca T. Levinson
    Citation: BMC Medicine 2023 21:267
  10. Increasing evidence suggests an association between pro-inflammatory diets and cognitive function. However, only a few studies based on small sample sizes have explored the association between pro-inflammatory...

    Authors: Yisen Shi, Fabin Lin, Yueping Li, Yingqing Wang, Xiaochun Chen, Fangang Meng, Qinyong Ye and Guoen Cai
    Citation: BMC Medicine 2023 21:266
  11. Prehabilitation aims at enhancing patients’ functional capacity and overall health status to enable them to withstand a forthcoming stressor like surgery. Our aim was to synthesise the evidence on the cost-eff...

    Authors: Tanja Rombey, Helene Eckhardt, Jörn Kiselev, Julia Silzle, Tim Mathes and Wilm Quentin
    Citation: BMC Medicine 2023 21:265
  12. Since the coronavirus disease 2019 (COVID-19) outbreak, many COVID-19 variants have emerged, causing several waves of pandemics and many infections. Long COVID-19, or long-term sequelae after recovery from COV...

    Authors: Deyu Zhang, Siyuan Weng, Chuanchao Xia, Yuqing Ren, Zaoqu Liu, Yudi Xu, Xiaoli Yang, Ruhao Wu, Lisi Peng, Liqi Sun, Jiaqi Zhu, Xuesong Liang, Yin Jia, Huaizhou Wang, Qian Chen, Dongtian Liu…
    Citation: BMC Medicine 2023 21:264
  13. It remains a challenge to predict the long-term response to antipsychotics in patients with schizophrenia who do not respond at an early stage. This study aimed to investigate the optimal predictive cut-off va...

    Authors: Yujun Long, Qiongqiong Wu, Ye Yang, Jingda Cai, Jingmei Xiao, Zhaoqian Liu, Yifeng Xu, Ying Chen, Manli Huang, Ruiguo Zhang, Xijia Xu, Jian Hu, Zhifen Liu, Fang Liu, Yingjun Zheng, Huaqing Meng…
    Citation: BMC Medicine 2023 21:263
  14. Probiotics are often used to prevent antibiotic-induced low-diversity dysbiosis, however their effect is not yet sufficiently summarized in this regard. We aimed to investigate the effects of concurrent probio...

    Authors: Anna Júlia Éliás, Viktória Barna, Cristina Patoni, Dóra Demeter, Dániel Sándor Veres, Stefania Bunduc, Bálint Erőss, Péter Hegyi, László Földvári-Nagy and Katalin Lenti
    Citation: BMC Medicine 2023 21:262
  15. Previous studies have found a correlation between coronavirus disease 2019 (COVID-19) and changes in brain structure and cognitive function, but it remains unclear whether COVID-19 causes brain structural chan...

    Authors: Shaojiong Zhou, Tao Wei, Xiaoduo Liu, Yufei Liu, Weiyi Song, Xinwei Que, Yi Xing, Zhibin Wang and Yi Tang
    Citation: BMC Medicine 2023 21:261
  16. Gestational diabetes mellitus (GDM) is associated with both short- and long-term risks, although it is unknown if risks vary by severity, timing, and duration of gestational hyperglycemia. We aimed to identify...

    Authors: Shuyun Chen, Margareta Persson, Rui Wang, Christina Dalman, Brian K. Lee, Håkan Karlsson and Renee M. Gardner
    Citation: BMC Medicine 2023 21:260
  17. To determine the extent and nature of changes associated with COVID-19 infection in terms of healthcare utilisation, this study observed healthcare contact 1 to 4 and 5 to 24 weeks following a COVID-19 diagnos...

    Authors: J Kennedy, M Parker, M Seaborne, M Mhereeg, A Walker, V Walker, S Denaxas, N Kennedy, S. V Katikireddi and S Brophy
    Citation: BMC Medicine 2023 21:259
  18. Preterm birth (PTB), defined as delivery before 37 gestational weeks, imposes significant public health burdens. A recent maternal genome-wide association study of spontaneous PTB identified a noncoding locus ...

    Authors: Li Wang, Robert M. Rossi, Xiaoting Chen, Jing Chen, Jilian Runyon, Mehak Chawla, Daniel Miller, Carmy Forney, Arthur Lynch, Xuzhe Zhang, Fansheng Kong, Bo Jacobsson, Leah C. Kottyan, Matthew T. Weirauch, Ge Zhang and Louis J. Muglia
    Citation: BMC Medicine 2023 21:258
  19. Valvular heart disease (VHD) can cause damage to extra-cardiac organs, and lead to multi-organ dysfunction. However, little is known about the cardio-renal-hepatic co-dysfunction, as well as its prognostic imp...

    Authors: Junxing Lv, Bin Zhang, Yunqing Ye, Zhe Li, Weiwei Wang, Qinghao Zhao, Qingrong Liu, Zhenyan Zhao, Haitong Zhang, Bincheng Wang, Zikai Yu, Zhenya Duan, Shuai Guo, Yanyan Zhao, Runlin Gao, Haiyan Xu…
    Citation: BMC Medicine 2023 21:257
  20. Genome-wide association studies (GWAS) have reported single-nucleotide polymorphisms (SNPs) in the VRK serine/threonine kinase 2 gene (VRK2) showing genome-wide significant associations with major depression, but...

    Authors: Mei-Yu Yin, Lei Guo, Li-Juan Zhao, Chen Zhang, Wei-Peng Liu, Chu-Yi Zhang, Jin-Hua Huo, Lu Wang, Shi-Wu Li, Chang-Bo Zheng, Xiao Xiao, Ming Li, Chuang Wang and Hong Chang
    Citation: BMC Medicine 2023 21:256
  21. The feasibility of DNA methylation-based assays in detecting minimal residual disease (MRD) and postoperative monitoring remains unestablished. We aim to investigate the dynamic characteristics of cancer-relat...

    Authors: Kezhong Chen, Guannan Kang, Zhihong Zhang, Analyn Lizaso, Stephan Beck, Iben Lyskjær, Olga Chervova, Bingsi Li, Haifeng Shen, Chenyang Wang, Bing Li, Heng Zhao, Xi Li, Fan Yang, Nnennaya Kanu and Jun Wang
    Citation: BMC Medicine 2023 21:255
  22. Schizophrenia and bipolar disorder (BD) are believed to share clinical symptoms, genetic risk, etiological factors, and pathogenic mechanisms. We previously reported that single nucleotide polymorphisms spanni...

    Authors: Zhi-Hui Yang, Xin Cai, Zhong-Li Ding, Wei Li, Chu-Yi Zhang, Jin-Hua Huo, Yue Zhang, Lu Wang, Lin-Ming Zhang, Shi-Wu Li, Ming Li, Chen Zhang, Hong Chang and Xiao Xiao
    Citation: BMC Medicine 2023 21:254
  23. PARP inhibitor (PARPi), as a kind of DNA damage repair inhibitor, has been shown to be effective in various solid tumors and hematologic malignancies. Natural killer/T cell lymphoma (NKTCL) is a highly aggress...

    Authors: Jiazhuo Wu, Cunzhen Shi, Hongwen Li, Wenting Song, Shuo Huang, Jianxiang Zhang, Wencai Li, Zhaoming Li and Mingzhi Zhang
    Citation: BMC Medicine 2023 21:253
  24. Calcific aortic valve disease (CAVD) is the most prevalent valvular disease and has high morbidity and mortality. CAVD is characterized by complex pathophysiological processes, including inflammation-induced o...

    Authors: Shunyi Li, Zichao Luo, Shuwen Su, Liming Wen, Gaopeng Xian, Jing Zhao, Xingbo Xu, Dingli Xu and Qingchun Zeng
    Citation: BMC Medicine 2023 21:252
  25. Cannabis consumption by pregnant women continues to increase worldwide, raising concerns about adverse effects on fetal growth and deleterious impacts on the newborn, in connection with evidence of placental t...

    Authors: J. Dochez-Arnault, C. Desdoits-Lethimonier, I. Matias, B. Evrard, M. Lagarrigue, M. Toupin, A. Lardenois, F. Chalmel, S. Mazaud-Guittot, N. Dejucq-Rainsford and A. Gely-Pernot
    Citation: BMC Medicine 2023 21:219
  26. A dietary pattern (DP) may impact on cancer incidence more strongly than individual foods, but this association remains uncertain. Here, we aimed to broadly explore the associations of an obesity-related DP wi...

    Authors: Maiwulamujiang Maimaitiyiming, Hongxi Yang, Lihui Zhou, Xinyu Zhang, Qiliang Cai and Yaogang Wang
    Citation: BMC Medicine 2023 21:251
  27. Inflammation has been implicated in the pathology of schizophrenia and may cause neuronal cell death and dendrite loss. Neuroimaging studies have highlighted longitudinal brain structural changes in patients w...

    Authors: Long-Biao Cui, Xian-Yang Wang, Yu-Fei Fu, Xiao-Fan Liu, Yongbin Wei, Shu-Wan Zhao, Yue-Wen Gu, Jing-Wen Fan, Wen-Jun Wu, Hengfen Gong, Bochao Danae Lin, Hong Yin, Fanglin Guan and Xiao Chang
    Citation: BMC Medicine 2023 21:250
  28. This study aimed to determine whether primary parathyroid cancer patients were associated with increased metabolic and cardiovascular comorbidities in comparison to the general population.

    Authors: Ming-Chieh Tsai, Min-Shu Hsu, Hsin-Yin Hsu, Tzu-Lin Yeh, Chun-Ju Chiang, Wen-Chung Lee, Jing-Rong Jhuang, Shih-Ping Cheng, Po-Jung Tseng and Kuo-Liong Chien
    Citation: BMC Medicine 2023 21:249
  29. The COVID-19 Vaccine Introduction and deployment Costing (CVIC) tool was developed to assist countries to estimate incremental financial costs to roll out COVID-19 vaccines. This article describes the purposes...

    Authors: Karene Hoi Ting Yeung, Eunkyoung Kim, Wei Aun Yap, Chansay Pathammavong, Lauren Franzel, Yu Lee Park, Peter Cowley, Ulla Kou Griffiths and Raymond Christiaan W. Hutubessy
    Citation: BMC Medicine 2023 21:248
  30. Providing informal care for a person with Parkinson’s disease (PD) can be a demanding process affecting several dimensions of a caregiver’s life and potentially causing caregiver burden. Despite the emerging l...

    Authors: Angelika D. Geerlings, Willanka M. Kapelle, Charlotte J. Sederel, Emma Tenison, Hilde Wijngaards-Berenbroek, Marjan J. Meinders, Marten Munneke, Yoav Ben-Shlomo, Bastiaan R. Bloem and Sirwan K. L. Darweesh
    Citation: BMC Medicine 2023 21:247
  31. Early phase dose-finding (EPDF) trials are crucial for the development of a new intervention and influence whether it should be investigated in further trials. Guidance exists for clinical trial protocols and ...

    Authors: Olga Solovyeva, Munyaradzi Dimairo, Christopher J. Weir, Siew Wan Hee, Aude Espinasse, Moreno Ursino, Dhrusti Patel, Andrew Kightley, Sarah Hughes, Thomas Jaki, Adrian Mander, Thomas R. Jeffry Evans, Shing Lee, Sally Hopewell, Khadija Rerhou Rantell, An-Wen Chan…
    Citation: BMC Medicine 2023 21:246
  32. Due to the asymptomatic nature of the early stages, chronic kidney disease (CKD) is usually diagnosed at late stages and lacks targeted therapy, highlighting the need for new biomarkers to better understand it...

    Authors: Jie-sheng Lin, Jana Nano, Agnese Petrera, Stefanie M. Hauck, Tanja Zeller, Wolfgang Koenig, Christian L. Müller, Annette Peters and Barbara Thorand
    Citation: BMC Medicine 2023 21:245
  33. Vaping cessation is virtually unexplored. The efficacy and safety of varenicline for vaping cessation has not been studied and rigorous research is required to advance best practice and outcomes for people who...

    Authors: Pasquale Caponnetto, Davide Campagna, Jasjit S. Ahluwalia, Christopher Russell, Marilena Maglia, Paolo Marco Riela, Carmelo Fabio Longo, Barbara Busa and Riccardo Polosa
    Citation: BMC Medicine 2023 21:220
  34. Randomised controlled trials are often beset by problems with poor recruitment and retention. Information to support decisions on trial participation is usually provided as printed participant information shee...

    Authors: Peter Knapp, Thirimon Moe-Byrne, Jacqueline Martin-Kerry, Rebecca Sheridan, Jenny Roche, Elizabeth Coleman, Peter Bower, Steven Higgins, Catherine Stones, Jonathan Graffy, Jenny Preston, Carrol Gamble, Bridget Young, Daniel Perry, Annegret Dahlmann-Noor, Mohamed Abbas…
    Citation: BMC Medicine 2023 21:244
  35. Elimination of mother-to-child transmission of hepatitis B virus (HBV) requires infant immunoprophylaxis and antiviral prophylaxis for pregnant women with high viral loads. Since real-time polymerase chain rea...

    Authors: Yasir Shitu Isa, Jonathan Sicsic, Henry Njuguna, John Ward, Mohamed Chakroun, Mohamed El-Kassas, Rado Ramanampamonjy, Salim Chalal, Jeanne Perpétue Vincent, Monique Andersson, Hailemichael Desalegn, Fatou Fall, Asgeir Johannessen, Philippa C. Matthews, Gibril Ndow, Edith Okeke…
    Citation: BMC Medicine 2023 21:243
  36. Several economic obstacles can deter the development and use of vaccines. This can lead to limited product options for some diseases, delays in new product development, and inequitable access to vaccines. Alth...

    Authors: Raymond Hutubessy, Jeremy A. Lauer, Birgitte Giersing, So Yoon Sim, Mark Jit, David Kaslow and Siobhan Botwright
    Citation: BMC Medicine 2023 21:229
  37. Whether diet has beneficial effects on cardiovascular disease (CVD) in childhood cancer survivors as in the general population is unknown. Therefore, we examined associations between dietary patterns and risk ...

    Authors: Tuo Lan, Mei Wang, Matthew J. Ehrhardt, Shu Jiang, Jennifer Q. Lanctot, Gregory T. Armstrong, Melissa M. Hudson, Graham A. Colditz, Leslie L. Robison and Yikyung Park
    Citation: BMC Medicine 2023 21:242
  38. The development of machine learning models for aiding in the diagnosis of mental disorder is recognized as a significant breakthrough in the field of psychiatry. However, clinical practice of such models remai...

    Authors: Zhiyi Chen, Bowen Hu, Xuerong Liu, Benjamin Becker, Simon B. Eickhoff, Kuan Miao, Xingmei Gu, Yancheng Tang, Xin Dai, Chao Li, Artemiy Leonov, Zhibing Xiao, Zhengzhi Feng, Ji Chen and Hu Chuan-Peng
    Citation: BMC Medicine 2023 21:241
  39. Breast cancer (BC) is the most common cancer type in women. The purpose of this study was to assess the eligibility criteria in recent clinical trials in BC, especially those that can limit the enrollment of o...

    Authors: Katarzyna Szlezinger, Katarzyna Pogoda, Agnieszka Jagiełło-Gruszfeld, Danuta Kłosowska, Andrzej Górski and Jan Borysowski
    Citation: BMC Medicine 2023 21:240
  40. It is unclear whether dobutamine, commonly used clinically in echocardiography and short-term congestive heart failure treatment for promoting increased myocardial contractility, affects brain microcirculatory...

    Authors: Tingting Zhang, Haijun Niu, Yawen Liu, Linkun Cai, Dong Liu, Erwei Zhao, Min Li, Wenjuan Liu, Jing Li, PengGang Qiao, Wei Zheng, Pengling Ren and Zhenchang Wang
    Citation: BMC Medicine 2023 21:238
  41. Schizophrenia is characterized by complex psychiatric symptoms and unclear pathological mechanisms. Most previous studies have focused on the morphological changes that occur over the development of the diseas...

    Authors: Sisi Jiang, Huan Huang, Jingyu Zhou, Hechun Li, Mingjun Duan, Dezhong Yao and Cheng Luo
    Citation: BMC Medicine 2023 21:237
  42. Primary care has been described as the ‘bedrock’ of the National Health Service (NHS) accounting for approximately 90% of patient contacts but is facing significant challenges. Against a backdrop of a rapidly ...

    Authors: Alexandra Jager, Geoff Wong, Chrysanthi Papoutsi and Nia Roberts
    Citation: BMC Medicine 2023 21:236
  43. Asialoglycoprotein receptor 1 (ASGR1) is emerging as a potential drug target to reduce low-density lipoprotein (LDL)-cholesterol and coronary artery disease (CAD) risk. Here, we investigated genetically mimick...

    Authors: Guoyi Yang and C. Mary Schooling
    Citation: BMC Medicine 2023 21:235
  44. In addition to improving survival outcomes, new oncology treatments should lead to amelioration of patients’ quality of life (QoL). Herein, we examined whether QoL results correlated with PFS and OS outcomes i...

    Authors: Alberto Servetto, Massimo Di Maio, Fabio Salomone, Fabiana Napolitano, Chiara Paratore, Fabrizio Di Costanzo, Giuseppe Viscardi, Antonio Santaniello, Luigi Formisano and Roberto Bianco
    Citation: BMC Medicine 2023 21:234
  45. Several COVID-19 vaccines are in widespread use in China. Few data exist on comparative immunogenicity of different COVID-19 vaccines given as booster doses. We aimed to assess neutralizing antibody levels rai...

    Authors: Fuzhen Wang, Baoying Huang, Yao Deng, Shaobai Zhang, Xiaoqiang Liu, Lei Wang, Qianqian Liu, Li Zhao, Lin Tang, Wenling Wang, Xiaoqi Wang, Fei Ye, Weijun Hu, Haitao Yang, Siquan Wang, Jiao Ren…
    Citation: BMC Medicine 2023 21:233
  46. Post-acute care (PAC) services after hospitalization for hip fracture are typically provided in skilled nursing facilities (SNFs), inpatient rehabilitation facilities (IRFs), or at home via home health care (H...

    Authors: Melissa R. Riester, Francesca L. Beaudoin, Richa Joshi, Kaleen N. Hayes, Meghan A. Cupp, Sarah D. Berry and Andrew R. Zullo
    Citation: BMC Medicine 2023 21:232
  47. A dysregulated postprandial metabolic response is a risk factor for chronic diseases, including type 2 diabetes mellitus (T2DM). The plasma protein N-glycome is implicated in both lipid metabolism and T2DM ris...

    Authors: Panayiotis Louca, Tamara Štambuk, Azra Frkatović-Hodžić, Ana Nogal, Massimo Mangino, Sarah E. Berry, Helena Deriš, George Hadjigeorgiou, Jonathan Wolf, Martina Vinicki, Paul W. Franks, Ana M. Valdes, Tim D. Spector, Gordan Lauc and Cristina Menni
    Citation: BMC Medicine 2023 21:231
  48. Surgery is a common treatment strategy for patients with neurofibromatosis type 1 (NF1)-related plexiform neurofibroma (PN) and has limited efficacy. FCN-159 is a novel anti-tumorigenic drug via selective inhi...

    Authors: Xiaojie Hu, Wenbin Li, Kang Zeng, Zhongyuan Xu, Changxing Li, Zhuang Kang, Shenglan Li, Xin Huang, Pu Han, Hongmei Lin, Ai-Min Hui, Yan Tan, Lei Diao, Ben Li, Xingli Wang, Zhuli Wu…
    Citation: BMC Medicine 2023 21:230