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  1. Congenital long QT syndrome (LQTS) is a rare heart disease caused by various underlying mutations. Most general cardiologists do not routinely see patients with congenital LQTS and may not always recognize the...

    Authors: Simona Aufiero, Hidde Bleijendaal, Tomas Robyns, Bert Vandenberk, Christian Krijger, Connie Bezzina, Aeilko H. Zwinderman, Arthur A. M. Wilde and Yigal M. Pinto
    Citation: BMC Medicine 2022 20:162
  2. Although social isolation has been associated with a higher mortality risk, little is known about the potential different impacts of face-to-face and non-face-to-face isolation on mortality. We examined the pr...

    Authors: Jiao Wang, Wei Sen Zhang, Chao Qiang Jiang, Feng Zhu, Ya Li Jin, Kar Keung Cheng, Tai Hing Lam and Lin Xu
    Citation: BMC Medicine 2022 20:178
  3. In December 2019, a new coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and associated disease, coronavirus disease 2019 (COVID-19), was identified in China. This virus spread quickly...

    Authors: Godfrey Bwire, Alex Riolexus Ario, Patricia Eyu, Felix Ocom, Joseph F. Wamala, Kwadwo A. Kusi, Latif Ndeketa, Kondwani C. Jambo, Rhoda K. Wanyenze and Ambrose O. Talisuna
    Citation: BMC Medicine 2022 20:167
  4. Over the last two centuries, researchers developed several assessments to evaluate the multidimensional construct of imagery. However, no comprehensive systematic review (SR) exists for imagery ability evaluat...

    Authors: Zorica Suica, Frank Behrendt, Szabina Gäumann, Ulrich Gerth, Arno Schmidt-Trucksäss, Thierry Ettlin and Corina Schuster-Amft
    Citation: BMC Medicine 2022 20:166
  5. Persistent fever, defined as fever lasting for 7 days or more at first medical evaluation, has been hardly investigated as a separate clinical entity in the tropics. This study aimed at exploring the frequenci...

    Authors: Emmanuel Bottieau, Lukas Van Duffel, Sayda El Safi, Kanika Deshpande Koirala, Basudha Khanal, Suman Rijal, Narayan Raj Bhattarai, Thong Phe, Kruy Lim, Deby Mukendi, Jean-Roger Lilo Kalo, Pascal Lutumba, Barbara Barbé, Jan Jacobs, Marjan Van Esbroeck, Nikki Foqué…
    Citation: BMC Medicine 2022 20:144
  6. HER2-low breast cancers were reported to have distinct clinicopathological characteristics from HER2-zero; however, the difference in their genetic features remains unclear. This study investigated the clinica...

    Authors: Guochun Zhang, Chongyang Ren, Cheukfai Li, Yulei Wang, Bo Chen, Lingzhu Wen, Minghan Jia, Kai Li, Hsiaopei Mok, Li Cao, Xiaoqing Chen, Jiali Lin, Guangnan Wei, Yingzhi Li, Yuchen Zhang, Charles M. Balch…
    Citation: BMC Medicine 2022 20:142
  7. Risk genes linked to the development of gout have been identified, and lifestyle factors are related to gout risk. It remains unclear whether healthy lifestyle factors can mitigate the genetic risk of gout. Th...

    Authors: Yuan Zhang, Rongrong Yang, Abigail Dove, Xuerui Li, Hongxi Yang, Shu Li, Ju Wang, Wei-Dong Li, Hongyu Zhao, Weili Xu and Yaogang Wang
    Citation: BMC Medicine 2022 20:138
  8. Individuals with autism spectrum disorder (ASD) are at particularly high risk of suicide and suicide attempts. Presentation to a hospital with self-harm is one of the strongest risk factors for later suicide. ...

    Authors: Emily Widnall, Sophie Epstein, Catherine Polling, Sumithra Velupillai, Amelia Jewell, Rina Dutta, Emily Simonoff, Robert Stewart, Ruth Gilbert, Tamsin Ford, Matthew Hotopf, Richard D. Hayes and Johnny Downs
    Citation: BMC Medicine 2022 20:137
  9. Prenatal maternal tobacco smoking is a predictor of child attention-deficit/hyperactivity disorder (ADHD) and is associated with offspring telomere length (TL). In this study, we examine the relationship betwe...

    Authors: Meghan P. Howell, Christopher W. Jones, Cade A. Herman, Celia V. Mayne, Camilo Fernandez, Katherine P. Theall, Kyle C. Esteves and Stacy S. Drury
    Citation: BMC Medicine 2022 20:153
  10. Preterm birth is defined as live birth before 37 completed weeks of pregnancy, and it is a major problem worldwide. The molecular mechanisms that lead to onset of spontaneous preterm birth are incompletely und...

    Authors: Heli Tiensuu, Antti M. Haapalainen, Pinja Tissarinen, Anu Pasanen, Tomi A. Määttä, Johanna M. Huusko, Steffen Ohlmeier, Ulrich Bergmann, Marja Ojaniemi, Louis J. Muglia, Mikko Hallman and Mika Rämet
    Citation: BMC Medicine 2022 20:141
  11. Ethnic differences in cardiovascular disease (CVD) risk have been known for decades, but a systematic exploration of how exposure and susceptibility to risk factors may contribute is lacking. This study aimed ...

    Authors: Frederick K. Ho, Stuart R. Gray, Paul Welsh, Jason M. R. Gill, Naveed Sattar, Jill P. Pell and Carlos Celis-Morales
    Citation: BMC Medicine 2022 20:149
  12. Poor graft function (PGF) or prolonged isolated thrombocytopenia (PT), which are characterized by pancytopenia or thrombocytopenia, have become serious complications after allogeneic hematopoietic stem cell tr...

    Authors: Yu Wang, Yuan Kong, Hong-Yan Zhao, Yuan-Yuan Zhang, Ya-Zhe Wang, Lan-Ping Xu, Xiao-Hui Zhang, Kai-Yan Liu and Xiao-Jun Huang
    Citation: BMC Medicine 2022 20:140
  13. There is evidence indicating that pesticide exposure is a risk factor for non-Hodgkin lymphoma (NHL) development. However, the association between pesticide exposure and NHL survival is not well-established.

    Authors: Christina Poh, John D. McPherson, Joseph Tuscano, Qian Li, Arti Parikh-Patel, Christoph F. A. Vogel, Myles Cockburn and Theresa Keegan
    Citation: BMC Medicine 2022 20:165
  14. Increasing age, male sex, and pre-existing comorbidities are associated with lower survival from SARS-CoV-2 infection. The interplay between different comorbidities, age, and sex is not fully understood, and i...

    Authors: Nanina Anderegg, Radoslaw Panczak, Matthias Egger, Nicola Low and Julien Riou
    Citation: BMC Medicine 2022 20:164
  15. Family history, and genetic and non-genetic risk factors can stratify women according to their individual risk of developing breast cancer. The extent of overlap between these risk predictors is not clear.

    Authors: Peh Joo Ho, Weang Kee Ho, Alexis J. Khng, Yen Shing Yeoh, Benita Kiat-Tee Tan, Ern Yu Tan, Geok Hoon Lim, Su-Ming Tan, Veronique Kiak Mien Tan, Cheng-Har Yip, Nur-Aishah Mohd-Taib, Fuh Yong Wong, Elaine Hsuen Lim, Joanne Ngeow, Wen Yee Chay, Lester Chee Hao Leong…
    Citation: BMC Medicine 2022 20:150
  16. Triple-negative breast cancer (TNBC) is a biologically diverse disease, with characteristics such as homologous recombination deficiency (HRD), gene mutation, and immune reactions. Japan Breast Cancer Research...

    Authors: Takayuki Ueno, Shigehisa Kitano, Norikazu Masuda, Daiki Ikarashi, Makiko Yamashita, Tomohiro Chiba, Takayuki Kadoya, Hiroko Bando, Takashi Yamanaka, Shoichiro Ohtani, Shigenori Nagai, Takahiro Nakayama, Masato Takahashi, Shigehira Saji, Kenjiro Aogi, Ravi Velaga…
    Citation: BMC Medicine 2022 20:136
  17. Data on the association between free-living daytime sunlight exposure and incident dementia are scarce. The objective is to evaluate whether the time spent in outdoor light is related to the dementia risk and ...

    Authors: Ling-Zhi Ma, Ya-Hui Ma, Ya-Nan Ou, Shi-Dong Chen, Liu Yang, Qiang Dong, Wei Cheng, Lan Tan and Jin-Tai Yu
    Citation: BMC Medicine 2022 20:132
  18. Higher dietary fibre intakes are associated with a reduced risk of developing cardiovascular disease (CVD), and increasing intake has been shown to reduce blood pressure and other cardiometabolic risk factors....

    Authors: Andrew N. Reynolds, Ashley Akerman, Shiristi Kumar, Huyen Tran Diep Pham, Sean Coffey and Jim Mann
    Citation: BMC Medicine 2022 20:139
  19. A significant subset of mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) gastric adenocarcinomas (GAC) are resistant to immune checkpoint inhibitors (ICIs), yet the underlying mechanism...

    Authors: Zhenghang Wang, Xinyu Wang, Yu Xu, Jian Li, Xiaotian Zhang, Zhi Peng, Yajie Hu, Xinya Zhao, Kun Dong, Bei Zhang, Chan Gao, Xiaochen Zhao, Hui Chen, Jinping Cai, Yuezong Bai, Yu Sun…
    Citation: BMC Medicine 2022 20:133
  20. The global burden of cardiovascular disease and type 2 diabetes could be decreased by improving dietary factors, but identification of groups suitable for interventional approaches can be difficult. Reporting ...

    Authors: Einar Smith, Ulrika Ericson, Sophie Hellstrand, Marju Orho-Melander, Peter M. Nilsson, Céline Fernandez, Olle Melander and Filip Ottosson
    Citation: BMC Medicine 2022 20:122
  21. Sub-Saharan Africa has seen substantial reductions in cases and deaths due to malaria over the past two decades. While this reduction is primarily due to an increasing expansion of interventions, urbanisation ...

    Authors: Arran Hamlet, Dereje Dengela, J. Eric Tongren, Fitsum G. Tadesse, Teun Bousema, Marianne Sinka, Aklilu Seyoum, Seth R. Irish, Jennifer S. Armistead and Thomas Churcher
    Citation: BMC Medicine 2022 20:135
  22. Tuberous sclerosis complex (TSC) is a rare multi-system genetic disorder characterised by the presence of benign tumours throughout multiple organs including the brain, kidneys, heart, liver, eyes, lungs and s...

    Authors: Jessica Robinson, Orhan Uzun, Ne Ron Loh, Isabelle Rose Harris, Thomas E. Woolley, Adrian J. Harwood, Jennifer Frances Gardner and Yasir Ahmed Syed
    Citation: BMC Medicine 2022 20:123
  23. Endometrial cancer is the most common gynaecological cancer in high-income countries. Elevated body mass index (BMI) is an established modifiable risk factor for this condition and is estimated to confer a lar...

    Authors: Emma Hazelwood, Eleanor Sanderson, Vanessa Y. Tan, Katherine S. Ruth, Timothy M. Frayling, Niki Dimou, Marc J. Gunter, Laure Dossus, Claire Newton, Neil Ryan, Dimitri J. Pournaras, Tracy A. O’Mara, George Davey Smith, Richard M. Martin and James Yarmolinsky
    Citation: BMC Medicine 2022 20:125
  24. Hearing loss has been associated with serious health problems around the globe. Previous studies have found the positive effects of fitting hearing aids on health, but few studies were conducted in developing ...

    Authors: Xin Ye, Dawei Zhu, Siyuan Chen, Xuefeng Shi, Rui Gong, Juncheng Wang, Huibin Zuo and Ping He
    Citation: BMC Medicine 2022 20:124
  25. It is unclear whether diet affects glycaemic control in type 2 diabetes (T2D), over and above its effects on bodyweight. We aimed to assess whether changes in dietary patterns altered glycaemic control indepen...

    Authors: James Garbutt, C. England, A. G. Jones, R. C. Andrews, R. Salway and L. Johnson
    Citation: BMC Medicine 2022 20:161
  26. Inflammation has been hypothesized to play a role in the development and progression of breast cancer and might differently impact breast cancer risk among pre and postmenopausal women. We performed a nested c...

    Authors: Manon Cairat, Sabina Rinaldi, Anne-Sophie Navionis, Isabelle Romieu, Carine Biessy, Vivian Viallon, Anja Olsen, Anne Tjønneland, Agnès Fournier, Gianluca Severi, Marina Kvaskoff, Renée T. Fortner, Rudolf Kaaks, Krasimira Aleksandrova, Matthias B. Schulze, Giovanna Masala…
    Citation: BMC Medicine 2022 20:118
  27. Endometriosis is a chronic, estrogen-dependent disorder where inflammation contributes to disease-associated symptoms of pelvic pain and infertility. Immune dysfunction includes insufficient immune lesion clea...

    Authors: Júlia Vallvé-Juanico, Ashley F. George, Sushmita Sen, Reuben Thomas, Min-Gyoung Shin, Divyashree Kushnoor, Joshua J. Vásquez, Kim Chi Vo, Juan C. Irwin, Nadia R. Roan, Alexis J. Combes and Linda C. Giudice
    Citation: BMC Medicine 2022 20:158
  28. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) community transmission was eliminated in Australia from 1/11/2020 to 30/6/2021, allowing evaluation of surveillance system performance in detecting ...

    Authors: Kamalini Lokuge, Katina D’Onise, Emily Banks, Tatum Street, Sydney Jantos, Mohana Baptista and Kathryn Glass
    Citation: BMC Medicine 2022 20:157
  29. Ketone body β-hydroxybutyrate (BHB) has received more and more attentions, because it possesses a lot of beneficial, life-preserving effects in the fields of clinical science and medicine. However, the role of...

    Authors: Chongyang Huang, Jun Wang, Hongbin Liu, Ruo Huang, Xinwen Yan, Mengyao Song, Gao Tan and Fachao Zhi
    Citation: BMC Medicine 2022 20:148
  30. Obesity in pregnancy and related early-life factors place the offspring at the highest risk of being overweight. Despite convincing evidence on these associations, there is an unmet public health need to ident...

    Authors: Delphina Gomes, Lien Le, Sarah Perschbacher, Nikolaus A. Haas, Heinrich Netz, Uwe Hasbargen, Maria Delius, Kristin Lange, Uta Nennstiel, Adelbert A. Roscher, Ulrich Mansmann and Regina Ensenauer
    Citation: BMC Medicine 2022 20:156
  31. People who use illicit opioids are more likely to be admitted to hospital than people of the same age in the general population. Many admissions end in discharge against medical advice, which is associated wit...

    Authors: Magdalena Harris, Adam Holland, Dan Lewer, Michael Brown, Niamh Eastwood, Gary Sutton, Ben Sansom, Gabby Cruickshank, Molly Bradbury, Isabelle Guest and Jenny Scott
    Citation: BMC Medicine 2022 20:151
  32. Reliable assessment of glycemia is central to the management of diabetes. The kidneys play a vital role in maintaining glucose homeostasis through glucose filtration, reabsorption, consumption, and generation....

    Authors: Mohamed Hassanein and Tariq Shafi
    Citation: BMC Medicine 2022 20:117
  33. Organ-specific metastatic context has not been incorporated into the clinical practice of guiding programmed death-(ligand) 1 [PD-(L)1] blockade, due to a lack of understanding of its predictive versus prognos...

    Authors: Si-Cong Ma, Xue Bai, Xue-Jun Guo, Li Liu, Lu-Shan Xiao, Yan Lin, Jia-Le Tan, Xiao-Ting Cai, Yu-Xiang Wen, Hu Ma, Q. John Fu, Meng-Xin Leng, Yan-Pei Zhang, Li-Li Long, Ze-Qin Guo, De-Hua Wu…
    Citation: BMC Medicine 2022 20:120
  34. Previous studies have reported associations between attention-deficit/hyperactivity disorder (ADHD) and lower socioeconomic status and intelligence. We aimed to evaluate the causal directions and strengths for...

    Authors: Madeleine Michaëlsson, Shuai Yuan, Håkan Melhus, John A. Baron, Liisa Byberg, Susanna C. Larsson and Karl Michaëlsson
    Citation: BMC Medicine 2022 20:106
  35. Preterm birth (PTB) is a syndrome resulting from a complex list of underlying causes and factors, and whether these risk factors differ in the context of prior PTB history is less understood. The aim of this s...

    Authors: Aline S. Rocha, Rita de Cássia Ribeiro-Silva, Rosemeire L. Fiaccone, Enny S. Paixao, Ila R. Falcão, Flavia Jôse O. Alves, Natanael J. Silva, Naiá Ortelan, Laura C. Rodrigues, Maria Yury Ichihara, Marcia F. de Almeida and Mauricio L. Barreto
    Citation: BMC Medicine 2022 20:111
  36. Dengue shock syndrome (DSS) is one of the major clinical phenotypes of severe dengue. It is defined by significant plasma leak, leading to intravascular volume depletion and eventually cardiovascular collapse....

    Authors: Huynh Trung Trieu, Lam Phung Khanh, Damien Keng Yen Ming, Chanh Ho Quang, Tu Qui Phan, Vinh Chau Nguyen Van, Ertan Deniz, Jane Mulligan, Bridget Ann Wills, Steven Moulton and Sophie Yacoub
    Citation: BMC Medicine 2022 20:109
  37. In March 2020, the UK implemented the Coronavirus Job Retention Scheme (furlough) to minimise job losses. Our aim was to investigate associations between furlough and diet, physical activity, and sleep during ...

    Authors: Bożena Wielgoszewska, Jane Maddock, Michael J. Green, Giorgio Di Gessa, Sam Parsons, Gareth J. Griffith, Jazz Croft, Anna J. Stevenson, Charlotte Booth, Richard J. Silverwood, David Bann, Praveetha Patalay, Alun D. Hughes, Nishi Chaturvedi, Laura D. Howe, Emla Fitzsimons…
    Citation: BMC Medicine 2022 20:147

    The Correction to this article has been published in BMC Medicine 2022 20:285

  38. Adding anti-angiogenics to neoadjuvant chemotherapy for localized gastric cancer is recognized as a promising strategy, but its clinical value remains to be defined.

    Authors: Zhaoqing Tang, Yan Wang, Yiyi Yu, Yuehong Cui, Liang Liang, Chen Xu, Zhenbin Shen, Kuntang Shen, Xuefei Wang, Tianshu Liu and Yihong Sun
    Citation: BMC Medicine 2022 20:107
  39. More doses of CoronaVac have been administered worldwide than any other COVID-19 vaccine. However, the effectiveness of COVID-19 inactivated vaccines in pregnant women is still unknown. We estimated the vaccin...

    Authors: Enny S. Paixao, Kerry L. M. Wong, Flavia Jôse Oliveira Alves, Vinicius de Araújo Oliveira, Thiago Cerqueira-Silva, Juracy Bertoldo Júnior, Tales Mota Machado, Elzo Pereira Pinto Junior, Viviane S. Boaventura, Gerson O. Penna, Guilherme Loureiro Werneck, Laura C. Rodrigues, Neil Pearce, Mauricio L. Barreto and Manoel Barral-Netto
    Citation: BMC Medicine 2022 20:146
  40. Selinexor 80 mg combined with low-dose dexamethasone (Sd) demonstrated significant clinical benefit in patients with relapsed/refractory multiple myeloma (RRMM) who had disease refractory to a proteasome inhib...

    Authors: Lugui Qiu, Zhongjun Xia, Chengcheng Fu, Wenming Chen, Chunkang Chang, Baijun Fang, Gang An, Yongqiang Wei, Zhen Cai, Sujun Gao, Jianyu Weng, Lijuan Chen, Hongmei Jing, Fei Li, Zhuogang Liu, Xiequn Chen…
    Citation: BMC Medicine 2022 20:108
  41. Dietary phytoestrogens have been suggested to influence puberty timing, a critical stage for well-being in adulthood. We hypothesized that childhood soy intake might prospectively influence puberty timing and ...

    Authors: Jingyuan Xiong, Yujie Xu, Xueting Liu, Xiaoyu Wang, Shufang Shan, M. James C. Crabbe, Li Zhao, He Fang and Guo Cheng
    Citation: BMC Medicine 2022 20:145
  42. Hundreds of millions of doses of coronavirus disease 2019 (COVID-19) vaccines have been administered globally, but progress on vaccination varies considerably between countries. We aimed to provide an overall ...

    Authors: Zhiyuan Chen, Wen Zheng, Qianhui Wu, Xinghui Chen, Cheng Peng, Yuyang Tian, Ruijia Sun, Jiayi Dong, Minghan Wang, Xiaoyu Zhou, Zeyao Zhao, Guangjie Zhong, Xuemei Yan, Nuolan Liu, Feiran Hao, Sihong Zhao…
    Citation: BMC Medicine 2022 20:130
  43. Limited data exist regarding the potential impact of assisted reproductive technology (ART) on cardiac remodeling. In particular, whether different ART techniques are related to different cardiac alterations r...

    Authors: Wenjing Bi, Yangjie Xiao, Xin Wang, Li Cui, Guang Song, Zeyu Yang, Ying Zhang and Weidong Ren
    Citation: BMC Medicine 2022 20:104
  44. Dietary interventions targeting the gut microbiota have been proposed as innovative strategies to improve obesity-associated metabolic disorders. Increasing physical activity (PA) is considered as a key behavi...

    Authors: Julie Rodriguez, Audrey M. Neyrinck, Maxime Van Kerckhoven, Marco A. Gianfrancesco, Edith Renguet, Luc Bertrand, Patrice D. Cani, Nicolas Lanthier, Miriam Cnop, Nicolas Paquot, Jean-Paul Thissen, Laure B. Bindels and Nathalie M. Delzenne
    Citation: BMC Medicine 2022 20:110
  45. SARS-CoV-2 infection portends a broad range of outcomes, from a majority of asymptomatic cases to a lethal disease. Robust correlates of severe COVID-19 include old age, male sex, poverty, and co-morbidities s...

    Authors: Emily Toscano-Guerra, Mónica Martínez-Gallo, Iria Arrese-Muñoz, Anna Giné, Noelia Díaz-Troyano, Pablo Gabriel-Medina, Mar Riveiro-Barciela, Moisés Labrador-Horrillo, Fernando Martinez-Valle, Adrián Sánchez Montalvá, Manuel Hernández-González, Ricardo Pujol Borrell, Francisco Rodríguez-Frias, Roser Ferrer, Timothy M. Thomson and Rosanna Paciucci
    Citation: BMC Medicine 2022 20:129
  46. Data on the relations between kidney function abnormalities and stroke in type 2 diabetes are limited. We evaluated the associations of kidney function abnormalities and chronic kidney disease (CKD) stages wit...

    Authors: Arnaud D. Kaze, Bernard G. Jaar, Gregg C. Fonarow and Justin B. Echouffo-Tcheugui
    Citation: BMC Medicine 2022 20:127
  47. Binding and neutralising anti-Spike antibodies play a key role in immune defence against SARS-CoV-2 infection. Since it is known that antibodies wane with time and new immune-evasive variants are emerging, we ...

    Authors: Marah G. Chibwana, Thandeka Moyo-Gwete, Gaurav Kwatra, Jonathan Mandolo, Tandile Hermanaus, Thopisang Motlou, Nonkululeko Mzindle, Frances Ayres, Mphatso Chaponda, Godwin Tembo, Percy Mwenechanya, Ndaona Mitole, Chisomo Jassi, Raphael Kamng’ona, Louise Afran, David Mzinza…
    Citation: BMC Medicine 2022 20:128
  48. Thymidine phosphorylase (TP), encoded by the TYMP gene, is a cytosolic enzyme essential for the nucleotide salvage pathway. TP catalyzes the phosphorylation of the deoxyribonucleosides, thymidine and 2′-deoxyurid...

    Authors: Jérémie Gautheron, Lara Lima, Baris Akinci, Jamila Zammouri, Martine Auclair, Sema Kalkan Ucar, Samim Ozen, Canan Altay, Bridget E. Bax, Ivan Nemazanyy, Véronique Lenoir, Carina Prip-Buus, Cécile Acquaviva-Bourdain, Olivier Lascols, Bruno Fève, Corinne Vigouroux…
    Citation: BMC Medicine 2022 20:95