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  1. In view of accumulating case reports of thyroid dysfunction following COVID-19 vaccination, we evaluated the risks of incident thyroid dysfunction following inactivated (CoronaVac) and mRNA (BNT162b2) COVID-19...

    Authors: Carlos King Ho Wong, David Tak Wai Lui, Xi Xiong, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Xue Li, Eric Yuk Fai Wan, Ching Lung Cheung, Chi Ho Lee, Yu Cho Woo, Ivan Chi Ho Au, Matthew Shing Hin Chung, Franco Wing Tak Cheng, Kathryn Choon Beng Tan and Ian Chi Kei Wong
    Citation: BMC Medicine 2022 20:339
  2. This study evaluated the persistence of IgM, IgA, and IgG to SARS-CoV-2 spike and nucleocapsid antigens up to 616 days since the onset of symptoms in a longitudinal cohort of 247 primary health care workers fr...

    Authors: Carlota Dobaño, Anna Ramírez-Morros, Selena Alonso, Rocío Rubio, Gemma Ruiz-Olalla, Josep Vidal-Alaball, Dídac Macià, Queralt Miró Catalina, Marta Vidal, Aina Fuster Casanovas, Esther Prados de la Torre, Diana Barrios, Alfons Jiménez, Jasmina Zanoncello, Natalia Rodrigo Melero, Carlo Carolis…
    Citation: BMC Medicine 2022 20:379
  3. The prevalence of some immune-mediated diseases (IMDs) shows distinct differences between populations of different ethnicities. The aim of this study was to determine if the age at diagnosis of common IMDs als...

    Authors: Archana Sharma-Oates, Dawit T. Zemedikun, Kanta Kumar, John A. Reynolds, Avinash Jain, Karim Raza, John A. Williams, Laura Bravo, Victor Roth Cardoso, Georgios Gkoutos, Krishnarajah Nirantharakumar and Janet M. Lord
    Citation: BMC Medicine 2022 20:346
  4. Current guidelines recommend rhythm control for improving symptoms and quality of life in symptomatic patients with atrial fibrillation (AF). However, the long-term prognostic outcomes of rhythm control compar...

    Authors: Wengen Zhu, Zexuan Wu, Yugang Dong, Gregory Y. H. Lip and Chen Liu
    Citation: BMC Medicine 2022 20:340
  5. Cervical insufficiency is one of the underlying causes of late miscarriage and preterm birth. Although many risk factors have been identified, the relative magnitude of their association with risk in nulliparo...

    Authors: Lili Meng, Sara Öberg, Anna Sandström, Chen Wang and Marie Reilly
    Citation: BMC Medicine 2022 20:348
  6. Early in the COVID-19 pandemic, countries adopted non-pharmaceutical interventions (NPIs) such as lockdowns to limit SARS-CoV-2 transmission. Social contact studies help measure the effectiveness of NPIs and e...

    Authors: Zlatina Dobreva, Amy Gimma, Hana Rohan, Benjamin Djoudalbaye, Akhona Tshangela, Christopher I. Jarvis, Kevin van Zandvoort and Matthew Quaife
    Citation: BMC Medicine 2022 20:344
  7. To prevent child deaths from severe malaria, early parenteral treatment is essential. Yet, in remote rural areas, accessing facilities offering parenteral antimalarials may be difficult. A randomised controlle...

    Authors: Manuel W. Hetzel, Jean Okitawutshu, Antoinette Tshefu, Elizabeth Omoluabi, Phyllis Awor, Aita Signorell, Nina C. Brunner, Jean-Claude Kalenga, Babatunde K. Akano, Kazeem Ayodeji, Charles Okon, Ocheche Yusuf, Proscovia Athieno, Joseph Kimera, Gloria Tumukunde, Irene Angiro…
    Citation: BMC Medicine 2022 20:343
  8. Instruments to critically appraise randomised controlled trials (RCTs) are based on evidence from meta-epidemiological studies. We aim to conduct a meta-epidemiological study on the average bias associated wit...

    Authors: Julia Stadelmaier, Isabelle Roux, Maria Petropoulou and Lukas Schwingshackl
    Citation: BMC Medicine 2022 20:330
  9. Regular vaccination against SARS-CoV-2 may be needed to maintain immunity in ‘at-risk’ populations, which include healthcare workers (HCWs). However, little is known about the proportion of HCWs who might be h...

    Authors: Neyme Veli, Christopher A. Martin, Katherine Woolf, Joshua Nazareth, Daniel Pan, Amani Al-Oraibi, Rebecca F. Baggaley, Luke Bryant, Laura B. Nellums, Laura J. Gray, Kamlesh Khunti and Manish Pareek
    Citation: BMC Medicine 2022 20:386
  10. Antiretroviral therapy (ART) adherence is still suboptimal among some key populations, highlighting the need for innovative tailored strategies. This randomized controlled trial (RCT) aimed to evaluate the eff...

    Authors: Kedi Jiao, Chunmei Wang, Meizhen Liao, Jing Ma, Dianmin Kang, Weiming Tang, Joseph D. Tucker and Wei Ma
    Citation: BMC Medicine 2022 20:341
  11. Diabetic kidney disease (DKD), the most common cause of kidney failure and end-stage kidney disease worldwide, will develop in almost half of all people with type 2 diabetes. With the incidence of type 2 diabe...

    Authors: Thomas Forst, Chantal Mathieu, Francesco Giorgino, David C. Wheeler, Nikolaos Papanas, Roland E. Schmieder, Atef Halabi, Oliver Schnell, Marina Streckbein and Katherine R. Tuttle
    Citation: BMC Medicine 2022 20:337
  12. Varicella zoster virus (VZV) is one of the eight known human herpesviruses. Initial VZV infection results in chickenpox, while viral reactivation following a period of latency manifests as shingles. Separate v...

    Authors: Kevin M Bakker, Marisa C Eisenberg, Robert J Woods and Micaela E Martinez
    Citation: BMC Medicine 2022 20:387
  13. A recent trial of 5920 children in Burkina Faso and Mali showed that the combination of seasonal vaccination with the RTS,S/AS01E malaria vaccine (primary series and two seasonal boosters) and seasonal malaria ch...

    Authors: Matthew Cairns, Amadou Barry, Issaka Zongo, Issaka Sagara, Serge R. Yerbanga, Modibo Diarra, Charles Zoungrana, Djibrilla Issiaka, Abdoul Aziz Sienou, Amadou Tapily, Koualy Sanogo, Mahamadou Kaya, Seydou Traore, Kalifa Diarra, Hama Yalcouye, Youssoufa Sidibe…
    Citation: BMC Medicine 2022 20:352
  14. Up to one of every six individuals diagnosed with one cancer will be diagnosed with a second primary cancer in their lifetime. Genetic factors contributing to the development of multiple primary cancers, beyon...

    Authors: Taylor B. Cavazos, Linda Kachuri, Rebecca E. Graff, Jovia L. Nierenberg, Khanh K. Thai, Stacey Alexeeff, Stephen Van Den Eeden, Douglas A. Corley, Lawrence H. Kushi, Thomas J. Hoffmann, Elad Ziv, Laurel A. Habel, Eric Jorgenson, Lori C. Sakoda and John S. Witte
    Citation: BMC Medicine 2022 20:332
  15. The durability of vaccine-induced humoral immunity against SARS-CoV-2 in patients with immune-mediated inflammatory diseases (IMIDs) on immunosuppressive therapy is not known. The aim of this study was to comp...

    Authors: Ingrid Egeland Christensen, Ingrid Jyssum, Anne Therese Tveter, Joseph Sexton, Trung T. Tran, Siri Mjaaland, Grete Birkeland Kro, Tore K. Kvien, David John Warren, Jørgen Jahnsen, Ludvig A. Munthe, Espen A. Haavardsholm, John Torgils Vaage, Gunnveig Grødeland, Fridtjof Lund-Johansen, Kristin Kaasen Jørgensen…
    Citation: BMC Medicine 2022 20:378
  16. Hormonal changes during the menstrual cycle play a key role in shaping immunity in the cervicovaginal tract. Cervicovaginal fluid contains cytokines, chemokines, immunoglobulins, and other immune mediators. Ma...

    Authors: Sean M. Hughes, Claire N. Levy, Ronit Katz, Erica M. Lokken, Melis N. Anahtar, Melissa Barousse Hall, Frideborg Bradley, Philip E. Castle, Valerie Cortez, Gustavo F. Doncel, Raina Fichorova, Paul L. Fidel Jr, Keith R. Fowke, Suzanna C. Francis, Mimi Ghosh, Loris Y. Hwang…
    Citation: BMC Medicine 2022 20:353
  17. The prevalence of combined heart failure (HF) and atrial fibrillation (AF) is rising, and these patients suffer from high rates of mortality. This study aims to provide robust data on factors associated with d...

    Authors: Otilia Țica, Ovidiu Țica, Karina V. Bunting, Joseph deBono, Georgios V. Gkoutos, Mircea I. Popescu and Dipak Kotecha
    Citation: BMC Medicine 2022 20:331
  18. Birth weight is considered not only to undermine future growth, but also to induce lifelong diseases; the aim of this study is to explore the relationship between birth weight and adult bone mass.

    Authors: Jiang-Wei Xia, Lin Zhang, Jin Li, Cheng-Da Yuan, Xiao-Wei Zhu, Yu Qian, Saber Khederzadeh, Jia-Xuan Gu, Lin Xu, Jian-Hua Gao, Ke-Qi Liu, David Karasik, Shu-Yang Xie, Guo-Bo Chen and Hou-Feng Zheng
    Citation: BMC Medicine 2022 20:361
  19. Malaria remains a leading cause of morbidity and mortality worldwide, with progress in malaria control stalling in recent years. Proactive community case management (pro-CCM) has been shown to increase access ...

    Authors: Rila Ratovoson, Andres Garchitorena, Daouda Kassie, Jemima A. Ravelonarivo, Voahangy Andrianaranjaka, Seheno Razanatsiorimalala, Avotra Razafimandimby, Fanjasoa Rakotomanana, Laurie Ohlstein, Reziky Mangahasimbola, Sandro A. N. Randrianirisoa, Jocelyn Razafindrakoto, Catherine M. Dentinger, John Williamson, Laurent Kapesa, Patrice Piola…
    Citation: BMC Medicine 2022 20:322
  20. West Africa has recorded a relatively higher proportion of asymptomatic coronavirus disease 2019 (COVID-19) cases than the rest of the world, and West Africa-specific host factors could play a role in this dis...

    Authors: Kesego Tapela, Fatima O. Oyawoye, Charles Ochieng’ Olwal, Precious C. Opurum, Jones Amo Amponsah, Kekeli Aku Lumor Segbedzi, Becky Tetteh, Frederick Kumi-Ansah, Joe K. Mutungi, Evangeline Obodai, Emmanuella Amoako, Seth Agyemang, Nicaise Tuikue Ndam, William Kwabena Ampofo, Julian C. Rayner, Gordon A. Awandare…
    Citation: BMC Medicine 2022 20:370
  21. The beneficial role of gut microbiota and bacterial metabolites, including short-chain fatty acids (SCFAs), is well recognized, although the available literature around their role in colorectal cancer (CRC) ha...

    Authors: Ehsan Alvandi, Wilson K. M. Wong, Mugdha V. Joglekar, Kevin J. Spring and Anandwardhan A. Hardikar
    Citation: BMC Medicine 2022 20:323
  22. Strategies to improve activity of immune checkpoint inhibitors for triple-negative breast cancer (TNBC) are needed. Preclinical studies showed that antiangiogenic agents and poly (ADP-ribose) polymerase (PARP)...

    Authors: Qingyuan Zhang, Bin Shao, Zhongsheng Tong, Quchang Ouyang, Yuting Wang, Guoying Xu, Shaorong Li and Huiping Li
    Citation: BMC Medicine 2022 20:321
  23. Mediterranean (MED) diet is a rich source of polyphenols, which benefit adiposity by several mechanisms. We explored the effect of the green-MED diet, twice fortified in dietary polyphenols and lower in red/pr...

    Authors: Hila Zelicha, Nora Kloting, Alon Kaplan, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Yoash Chassidim, Matthias Bluher, Uta Ceglarek, Berend Isermann, Michael Stumvoll, Rita Nana Quayson, Martin von Bergen, Beatrice Engelmann, Ulrike E. Rolle-Kampczyk, Sven-Bastiaan Haange…
    Citation: BMC Medicine 2022 20:327
  24. Long noncoding RNAs (lncRNAs) have emerged as important regulators in a variety of human diseases. The dysregulation of liver sinusoidal endothelial cell (LSEC) phenotype is a critical early event in the fibro...

    Authors: Ting Chen, Zhemin Shi, Yanmian Zhao, Xiaoxiang Meng, Sicong Zhao, Lina Zheng, Xiaohui Han, Zhimei Hu, Qingbin Yao, Huajiang Lin, Xiaoxiao Du, Kun Zhang, Tao Han and Wei Hong
    Citation: BMC Medicine 2022 20:335
  25. Studies often evaluate mental health and well-being in association with individual health behaviours although evaluating multiple health behaviours that co-occur in real life may reveal important insights into...

    Authors: Pauline Hautekiet, Nelly D. Saenen, Dries S. Martens, Margot Debay, Johan Van der Heyden, Tim S. Nawrot and Eva M. De Clercq
    Citation: BMC Medicine 2022 20:328
  26. Identifying pregnancies at risk for preterm birth, one of the leading causes of worldwide infant mortality, has the potential to improve prenatal care. However, we lack broadly applicable methods to accurately...

    Authors: Abin Abraham, Brian Le, Idit Kosti, Peter Straub, Digna R. Velez-Edwards, Lea K. Davis, J. M. Newton, Louis J. Muglia, Antonis Rokas, Cosmin A. Bejan, Marina Sirota and John A. Capra
    Citation: BMC Medicine 2022 20:333
  27. Tuberculosis remains the leading cause of death from a single infectious disease worldwide. Trials evaluating digital adherence technologies for tuberculosis in low- and middle-income countries are urgently ne...

    Authors: Tsegahun Manyazewal, Yimtubezinash Woldeamanuel, David P. Holland, Abebaw Fekadu and Vincent C. Marconi
    Citation: BMC Medicine 2022 20:310
  28. In vitro drug screening studies have indicated that camostat mesilate (FOY-305) may prevent SARS-CoV-2 infection into human airway epithelial cells. This study was conducted to investigate whether camostat mes...

    Authors: Taku Kinoshita, Masahiro Shinoda, Yasuhiro Nishizaki, Katsuya Shiraki, Yuji Hirai, Yoshiko Kichikawa, Kenji Tsushima, Masaharu Sinkai, Naoyuki Komura, Kazuo Yoshida, Yasutoshi Kido, Hiroshi Kakeya, Naoto Uemura and Junichi Kadota
    Citation: BMC Medicine 2022 20:342
  29. Age is the strongest risk factor for dementia and there is considerable interest in identifying scalable, blood-based biomarkers in predicting dementia. We examined the role of midlife serum metabolites using ...

    Authors: Marcos D. Machado-Fragua, Benjamin Landré, Mathilde Chen, Aurore Fayosse, Aline Dugravot, Mika Kivimaki, Séverine Sabia and Archana Singh-Manoux
    Citation: BMC Medicine 2022 20:334
  30. In the context of the COVID-19 pandemic, randomized controlled trials (RCTs) are essential to support clinical decision-making. We aimed (1) to assess and compare the reporting characteristics of RCTs between ...

    Authors: Philipp Kapp, Laura Esmail, Lina Ghosn, Philippe Ravaud and Isabelle Boutron
    Citation: BMC Medicine 2022 20:363
  31. Capecitabine maintenance therapy is safe and efficacious for early-stage triple-negative breast cancer (TNBC) patients, but the cost-effectiveness of its long-term use has not been investigated. Here, we evalu...

    Authors: Ji-Bin Li, Zhuo-Chen Lin, Martin C. S. Wong, Harry H. X. Wang, Mengmeng Li and Su Li
    Citation: BMC Medicine 2022 20:320
  32. Delirium is common after hip fracture surgery, affecting up to 50% of patients. The incidence of delirium may be influenced by mode and conduct of anaesthesia. We examined the effect of spinal anaesthesia (wit...

    Authors: Gulraj S. Matharu, Anjali Shah, Samuel Hawley, Antony Johansen, Dominic Inman, Iain Moppett, Michael R. Whitehouse and Andrew Judge
    Citation: BMC Medicine 2022 20:319
  33. Offspring born to women with pregestational type 1 diabetes (T1DM) are exposed to an intrauterine hyperglycemic milieu and has an increased risk of metabolic disease later in life. In this present study, we hy...

    Authors: Sine Knorr, Anne Skakkebæk, Jesper Just, Emma B. Johannsen, Christian Trolle, Søren Vang, Zuzana Lohse, Birgitte Bytoft, Peter Damm, Kurt Højlund, Dorte M. Jensen and Claus H. Gravholt
    Citation: BMC Medicine 2022 20:338
  34. The type 2 diabetes risk after gestational diabetes mellitus (GDM) is twice as high in South Asian compared to European women. Current guidelines differ regarding which test to use as a screening-tool post-GDM...

    Authors: Archana Sharma, Ingrid Nermoen, Elisabeth Qvigstad, Anh T. Tran, Christine Sommer, Naveed Sattar, Jason M. R. Gill, Hanne L. Gulseth, Stina T. Sollid and Kåre I. Birkeland
    Citation: BMC Medicine 2022 20:318
  35. Home-based palliative care (HPC) is considered to moderate the problem of rising healthcare utilization of cancer patients at end-of-life. Reports however suggest a proportion of HPC patients continue to exper...

    Authors: Qingyuan Zhuang, Poh-Heng Chong, Whee Sze Ong, Zhi Zheng Yeo, Cherylyn Qun Zhen Foo, Su Yan Yap, Guozhang Lee, Grace Meijuan Yang and Sungwon Yoon
    Citation: BMC Medicine 2022 20:313
  36. Most tobacco users initiate smoking during adolescence. Little is known about the global prevalence and trends in early cigarette smoking among adolescents. This study aimed to evaluate the prevalence of early...

    Authors: Huaqing Liu, Qi Qi, Ying Duan, Chuanwei Ma and Chengchao Zhou
    Citation: BMC Medicine 2022 20:311
  37. Employment disruptions can impact smoking and alcohol consumption. During the COVID-19 pandemic, many countries implemented furlough schemes to prevent job loss. We examine how furlough was associated with smo...

    Authors: Michael J. Green, Jane Maddock, Giorgio Di Gessa, Bożena Wielgoszewska, Sam Parsons, Gareth J. Griffith, Jazz Croft, Anna J. Stevenson, Charlotte F. Huggins, Charlotte Booth, Jacques Wels, Richard J. Silverwood, Praveetha Patalay, Alun D. Hughes, Nishi Chaturvedi, Laura D. Howe…
    Citation: BMC Medicine 2022 20:345
  38. The relationship between vitamin D status and mortality in patients with osteoarthritis (OA) is unknown. This study investigated the associations of serum 25-hydroxyvitamin D [25(OH)D] concentrations with all-...

    Authors: Qingqing Xiao, Bin Cai, Anwen Yin, Huanhuan Huo, Keke Lan, Guo Zhou, Linghong Shen and Ben He
    Citation: BMC Medicine 2022 20:308
  39. The results of a randomised trial showed the safety and efficacy of Gam-COVID-Vac against COVID-19. However, compared to other vaccines used across the globe, the real-world data on the effectiveness of Gam-CO...

    Authors: Anton Barchuk, Mikhail Cherkashin, Anna Bulina, Natalia Berezina, Tatyana Rakova, Darya Kuplevatskaya, Oksana Stanevich, Dmitriy Skougarevskiy and Artemiy Okhotin
    Citation: BMC Medicine 2022 20:312
  40. Non-communicable diseases (NCDs) are a leading cause of maternal mortality and morbidity worldwide. The World Health Organization is developing new recommendations focusing on the management of NCDs for pregna...

    Authors: Jenny Jung, Eshreena K. Karwal, Steve McDonald, Tari Turner, Doris Chou and Joshua P. Vogel
    Citation: BMC Medicine 2022 20:305
  41. Obesity is a well-established risk factor for atrial fibrillation (AF). Whether body fat depots differentially associate with AF development remains unknown.

    Authors: Zuolin Lu, Martijn J. Tilly, Elif Aribas, Daniel Bos, Sven Geurts, Bruno H. Stricker, Robert de Knegt, M. Arfan Ikram, Natasja M. S. de Groot, Trudy Voortman and Maryam Kavousi
    Citation: BMC Medicine 2022 20:317
  42. Although observational studies have reported associations between serum C-reactive protein (CRP) concentration and risks of lung, breast, and colorectal cancer, inconsistent or absent evidences were showed for...

    Authors: Meng Zhu, Zhimin Ma, Xu Zhang, Dong Hang, Rong Yin, Jifeng Feng, Lin Xu and Hongbing Shen
    Citation: BMC Medicine 2022 20:301
  43. In 2012, the World Health Organization (WHO) recommended single low-dose (SLD, 0.25 mg/kg) primaquine to be added as a Plasmodium (P.) falciparum gametocytocide to artemisinin-based combination therapy (ACT) with...

    Authors: Kasia Stepniewska, Elizabeth N. Allen, Georgina S. Humphreys, Eugenie Poirot, Elaine Craig, Kalynn Kennon, Daniel Yilma, Teun Bousema, Philippe J. Guerin, Nicholas J. White, Ric N. Price, Jaishree Raman, Andreas Martensson, Richard O. Mwaiswelo, Germana Bancone, Guido J. H. Bastiaens…
    Citation: BMC Medicine 2022 20:350
  44. Heterogeneity of the population in relation to infection, COVID-19 vaccination, and host characteristics is likely reflected in the underlying SARS-CoV-2 antibody responses.

    Authors: Marianna Karachaliou, Gemma Moncunill, Ana Espinosa, Gemma Castaño-Vinyals, Rocío Rubio, Marta Vidal, Alfons Jiménez, Esther Prados, Anna Carreras, Beatriz Cortés, Natàlia Blay, Marc Bañuls, Vanessa Pleguezuelos, Natalia Rodrigo Melero, Pau Serra, Daniel Parras…
    Citation: BMC Medicine 2022 20:347
  45. Lack of representativeness in Black, Indigenous, and People of Colour (BIPOC) enrollment could compromise the generalizability of study results and health equity. This study aimed to examine trends in BIPOC gr...

    Authors: Jingyi Zhang, Harriette G. C. Van Spall, Yaoyao Wang, Lehana Thabane, Ruoting Wang and Guowei Li
    Citation: BMC Medicine 2022 20:294
  46. Endometriosis is a common, complex disorder which is underrecognized and subject to prolonged delays in diagnosis. It is accompanied by significant changes in the eutopic endometrial lining.

    Authors: Andrew J. Shih, Robert P. Adelson, Himanshu Vashistha, Houman Khalili, Ashima Nayyar, Radha Puran, Rixsi Herrera, Prodyot K. Chatterjee, Annette T. Lee, Alexander M. Truskinovsky, Kristine Elmaliki, Margaret DeFranco, Christine N. Metz and Peter K. Gregersen
    Citation: BMC Medicine 2022 20:315
  47. Gestational diabetes (GDM) is prevalent and benefits from timely and effective treatment, given the short window to impact glycemic control. Clinicians face major barriers to choosing effectively among treatme...

    Authors: Lauren D. Liao, Assiamira Ferrara, Mara B. Greenberg, Amanda L. Ngo, Juanran Feng, Zhenhua Zhang, Patrick T. Bradshaw, Alan E. Hubbard and Yeyi Zhu
    Citation: BMC Medicine 2022 20:307