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  1. The emergence of new SARS-CoV-2 variants and the waning of immunity raise concerns about vaccine effectiveness and protection against COVID-19. While antibody response has been shown to correlate with the risk...

    Authors: Carla Martín Pérez, Ruth Aguilar, Alfons Jiménez, Gemma Salmerón, Mar Canyelles, Rocío Rubio, Marta Vidal, Inocencia Cuamba, Diana Barrios, Natalia Díaz, Rebeca Santano, Pau Serra, Pere Santamaria, Luis Izquierdo, Antoni Trilla, Anna Vilella…
    Citation: BMC Medicine 2024 22:103
  2. Diabetes patients are at higher risk for mortality than the general population; however, little is known about whether the excess mortality risk associated with diabetes could be mitigated or nullified via con...

    Authors: Jian Zhou, Xuan Wang, Rui Tang, Minghao Kou, Hao Ma, Xiang Li, Yoriko Heianza, Vivian Fonseca and Lu Qi
    Citation: BMC Medicine 2024 22:108
  3. Classical Hodgkin lymphoma (cHL) is a highly curable disease, while novel therapy is needed for refractory or relapsed (R/R) patients. This phase II trial aimed to evaluate the role of camrelizumab plus gemcit...

    Authors: Yanfei Liu, Lingyan Ping, Yuqin Song, Yongjing Tang, Wen Zheng, Weiping Liu, Zhitao Ying, Chen Zhang, Meng Wu, Feier Feng, Ningjing Lin, Meifeng Tu, Jun Zhu and Yan Xie
    Citation: BMC Medicine 2024 22:107
  4. The relaxation of the “zero-COVID” policy on Dec. 7, 2022, in China posed a major public health threat recently. Complete blood count test was discovered to have complicated relationships with COVID-19 after t...

    Authors: Yifei Lin, Yong Yang, Nanyan Xiang, Le Wang, Tao Zheng, Xuejun Zhuo, Rui Shi, Xiaoyi Su, Yan Liu, Ga Liao, Liang Du and Jin Huang
    Citation: BMC Medicine 2024 22:105
  5. The specific microbiota and associated metabolites linked to non-alcoholic fatty liver disease (NAFLD) are still controversial. Thus, we aimed to understand how the core gut microbiota and metabolites impact N...

    Authors: Fangfang Zeng, Xin Su, Xinxiu Liang, Minqi Liao, Haili Zhong, Jinjian Xu, Wanglong Gou, Xiangzhou Zhang, Luqi Shen, Ju-Sheng Zheng and Yu-ming Chen
    Citation: BMC Medicine 2024 22:104
  6. Empirical evidence suggests that lack of blinding may be associated with biased estimates of treatment benefit in randomized controlled trials, but the influence on medication-related harms is not well-recogni...

    Authors: Chang Xu, Fengying Zhang, Suhail A. R. Doi, Luis Furuya-Kanamori, Lifeng Lin, Haitao Chu, Xi Yang, Sheyu Li, Liliane Zorzela, Su Golder, Yoon Loke and Sunita Vohra
    Citation: BMC Medicine 2024 22:83
  7. Effectively managing the coexistence of both diabetes and disability necessitates substantial effort. Whether disability onset affects adherence to type 2 diabetes medication remains unclear. This study invest...

    Authors: Szu-Han Chen, Miaw-Chwen Lee and Christy Pu
    Citation: BMC Medicine 2024 22:102
  8. Non-alcoholic fatty liver disease (NAFLD) and metabolic-associated fatty liver disease (MAFLD) shares common pathophysiological mechanisms with type 2 diabetes, making them significant risk factors for type 2 ...

    Authors: Limin Cao, Yu An, Huiyuan Liu, Jinguo Jiang, Wenqi Liu, Yuhan Zhou, Mengyuan Shi, Wei Dai, Yanling Lv, Yuhong Zhao, Yanhui Lu, Liangkai Chen and Yang Xia
    Citation: BMC Medicine 2024 22:101
  9. In 2021, whilst societies were emerging from major social restrictions during the SARS-CoV-2 pandemic, the UK government instigated an Events Research Programme to examine the risk of COVID-19 transmission fro...

    Authors: Ian J. Douglas, Jerlyn Peh, Kathryn E. Mansfield, Anna Trelfa, Tom Fowler, Matthew Boulter, Paul Cleary, Jenifer Smith and W. John Edmunds
    Citation: BMC Medicine 2024 22:100
  10. The increasing prevalence of gestational diabetes mellitus (GDM) is a major challenge, particularly in rural areas of China where control rates are suboptimal. This study aimed to evaluate the effectiveness of...

    Authors: Tingting Xu, Qing Xia, Xiaozhen Lai, Kun He, Dazhi Fan, Liangkun Ma and Hai Fang
    Citation: BMC Medicine 2024 22:98
  11. Carbohydrates have been implicated in colorectal cancer (CRC) risk, but the specific impact of carbohydrate quality and quantity on CRC susceptibility in US populations remains unclear.

    Authors: Yi Xiao, Ling Xiang, Yahui Jiang, Yunhao Tang, Haitao Gu, Yaxu Wang and Linglong Peng
    Citation: BMC Medicine 2024 22:97
  12. There is a lack of effective therapeutic strategies for amyotrophic lateral sclerosis (ALS); therefore, drug repurposing might provide a rapid approach to meet the urgent need for treatment.

    Authors: Qing-Qing Duan, Han Wang, Wei-Ming Su, Xiao-Jing Gu, Xiao-Fei Shen, Zheng Jiang, Yan-Ling Ren, Bei Cao, Guo-Bo Li, Yi Wang and Yong-Ping Chen
    Citation: BMC Medicine 2024 22:96
  13. The key role of thrombospondin 1 (THBS1) in the pathogenesis of acute-on-chronic liver failure (ACLF) is unclear. Here, we present a transcriptome approach to evaluate THBS1 as a potential biomarker in ACLF di...

    Authors: Hozeifa Mohamed Hassan, Xi Liang, Jiaojiao Xin, Yingyan Lu, Qun Cai, Dongyan Shi, Keke Ren, Jun Li, Qi Chen, Jiang Li, Peng Li, Beibei Guo, Hui Yang, Jinjin Luo, Heng Yao, Xingping Zhou…
    Citation: BMC Medicine 2024 22:95
  14. There is a high prevalence of autoimmune conditions in women specially in the reproductive years; thus, the association with adverse pregnancy outcomes has been widely studied. However, few autoimmune conditio...

    Authors: Megha Singh, Steven Wambua, Siang Ing Lee, Kelvin Okoth, Zhaonan Wang, Fathima Fazla Ahamed Fayaz, Kelly-Ann Eastwood, Catherine Nelson-Piercy, John A. Reynolds, Krishnarajah Nirantharakumar and Francesca Crowe
    Citation: BMC Medicine 2024 22:94
  15. Cardiovascular disease (CVD) caused by air pollution poses a considerable burden on public health. We aim to examine whether lifestyle factors mediate the associations of air pollutant exposure with the risk o...

    Authors: Xiangming Hu, Luke D. Knibbs, Yingling Zhou, Yanqiu Ou, Guang-Hui Dong and Haojian Dong
    Citation: BMC Medicine 2024 22:93
  16. Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are neurodevelopmental disorders with overlapping behavioral features and genetic etiology. While brain cortical thickness (CT...

    Authors: Wanfang You, Qian Li, Lizhou Chen, Ning He, Yuanyuan Li, Fenghua Long, Yaxuan Wang, Yufei Chen, Robert K. McNamara, John A. Sweeney, Melissa P. DelBello, Qiyong Gong and Fei Li
    Citation: BMC Medicine 2024 22:92
  17. Epilepsy, characterized by recurrent unprovoked seizures, poses significant challenges to affected individuals globally. While several established risk factors for epilepsy exist, the association with cigarett...

    Authors: Yerin Kang, Sieun Kim, Yunah Jung, Dai Sik Ko, Hyun-Woo Kim, Jung-Pil Yoon, Sunghwan Cho, Tae-Jin Song, Kihun Kim, Eunjeong Son and Yun Hak Kim
    Citation: BMC Medicine 2024 22:91
  18. While circulating metabolites have been increasingly linked to cancer risk, the causality underlying these associations remains largely uninterrogated.

    Authors: Yaxin Chen, Yufang Xie, Hang Ci, Zhengpei Cheng, Yongjie Kuang, Shuqing Li, Gang Wang, Yawen Qi, Jun Tang, Dan Liu, Weimin Li and Yaohua Yang
    Citation: BMC Medicine 2024 22:90
  19. Black men have higher prostate-specific antigen (PSA) levels and higher prostate cancer incidence and mortality than White men, while Asian men tend to have lower prostate cancer incidence and mortality than W...

    Authors: Liz Down, Melissa Barlow, Sarah E. R. Bailey, Luke T. A. Mounce, Samuel W. D. Merriel, Jessica Watson and Tanimola Martins
    Citation: BMC Medicine 2024 22:82
  20. Dairy contains a complex mixture of lipids, proteins, and micronutrients. Whether habitual dairy consumption is associated with health benefits is not well established. Since dairy is high in nutrients that ar...

    Authors: Ellen A. Struijk, Teresa T. Fung, Fernando Rodriguez-Artalejo, Heike A. Bischoff-Ferrari, Walter C. Willett and Esther Lopez-Garcia
    Citation: BMC Medicine 2024 22:89
  21. Peer support for mental health is recommended across international policy guidance and provision. Our systematic umbrella review summarises evidence on the effectiveness, implementation, and experiences of pai...

    Authors: Ruth E. Cooper, Katherine R. K. Saunders, Anna Greenburgh, Prisha Shah, Rebecca Appleton, Karen Machin, Tamar Jeynes, Phoebe Barnett, Sophie M. Allan, Jessica Griffiths, Ruth Stuart, Lizzie Mitchell, Beverley Chipp, Stephen Jeffreys, Brynmor Lloyd-Evans, Alan Simpson…
    Citation: BMC Medicine 2024 22:72
  22. The risk of incident atrial fibrillation (AF) among breast cancer survivors, especially for younger women, and cancer treatment effects on the association remain unclear. This study aimed to investigate the ri...

    Authors: Yong-Moon Mark Park, Wonyoung Jung, Yohwan Yeo, Sang Hyun Park, Michael G. Fradley, Sindhu J. Malapati, Tushar Tarun, Vinay Raj, Hong Seok Lee, Tasneem Z. Naqvi, Ronda S. Henry-Tillman, Jawahar L. Mehta, Mario Schootman, Benjamin C. Amick III, Kyungdo Han and Dong Wook Shin
    Citation: BMC Medicine 2024 22:88
  23. Myocardial bridging (MB) is common in patients with hypertrophic cardiomyopathy (HCM). There are sparse data on the impact of MB on myocardial fibrosis in HCM. This study was designed to evaluate the relations...

    Authors: Changpeng Song, Shengwei Wang, Xinli Guo, Manyun Huang, Xinxin Zheng, Jie Lu, Keshan Ji, Shihua Zhao, Jingang Cui, Shuiyun Wang and Xiaohong Huang
    Citation: BMC Medicine 2024 22:86
  24. For patients with steroid-refractory acute graft-versus-host disease (SR-aGVHD), effective second-line regimens are urgently needed. Mesenchymal stromal cells (MSCs) have been used as salvage regimens for SR-a...

    Authors: Haixia Fu, Xueyan Sun, Ren Lin, Yu Wang, Li Xuan, Han Yao, Yuanyuan Zhang, Xiaodong Mo, Meng lv, Fengmei Zheng, Jun Kong, Fengrong Wang, Chenhua Yan, Tingting Han, Huan Chen, Yao Chen…
    Citation: BMC Medicine 2024 22:85
  25. It has been repeatedly shown that men infected by SARS-CoV-2 face a twofold higher likelihood of dying, being hospitalized or admitted to the intensive care unit compared to women, despite taking into account ...

    Authors: Evangelia Elenis, Helena Kopp Kallner, Maria A. Karalexi, David Hägg, Marie Linder, Katja Fall, Fotios C. Papadopoulos and Alkistis Skalkidou
    Citation: BMC Medicine 2024 22:84
  26. Caffeine is one of the most utilized drugs in the world, yet its clinical effects are not fully understood. Circulating caffeine levels are influenced by the interplay between consumption behaviour and metabol...

    Authors: Loukas Zagkos, Héléne T. Cronjé, Benjamin Woolf, Roxane de La Harpe, Stephen Burgess, Christos S. Mantzoros, Paul Elliott, Shuai Yuan, Susanna C. Larsson, Ioanna Tzoulaki and Dipender Gill
    Citation: BMC Medicine 2024 22:81
  27. Dysbiosis of the gut microbiome is frequent in the intensive care unit (ICU), potentially leading to a heightened risk of nosocomial infections. Enhancing the gut microbiome has been proposed as a strategic ap...

    Authors: Vinod K. Gupta, Sanu Rajendraprasad, Mahmut Ozkan, Dhanya Ramachandran, Sumera Ahmad, Johan S. Bakken, Krzysztof Laudanski, Ognjen Gajic, Brent Bauer, Simon Zec, David W. Freeman, Sahil Khanna, Aditya Shah, Joseph H. Skalski, Jaeyun Sung and Lioudmila V. Karnatovskaia
    Citation: BMC Medicine 2024 22:80
  28. The immunity induced by primary vaccination is effective against COVID-19; however, booster vaccines are needed to maintain vaccine-induced immunity and improve protection against emerging variants. Heterologo...

    Authors: Saeed Erfanpoor, Seyed Reza Banihashemi, Ladan Mokhbaeralsafa, Saeed Kalantari, Ali Es-haghi, Mojtaba Nofeli, Ali Rezaei Mokarram, Fariba Sadeghi, Monireh Hajimoradi, Seyad Hossein Razaz, Maryam Taghdiri, Mohsen Lotfi, Akbar Khorasani, Akram Ansarifar, Safdar Masoumi, Arash Mohazzab…
    Citation: BMC Medicine 2024 22:78
  29. The coexistence of hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (HBsAb) represents an uncommon serological pattern observed in patients with hepatitis B virus (HBV) infection, and its u...

    Authors: Yingping Gu, Shuangjie Li, Zhenzhen Yao, Xin Lai, Meng Yang, Yi Xu and Songxu Peng
    Citation: BMC Medicine 2024 22:77
  30. To combat the opioid crisis, interventions targeting the opioid prescribing behaviour of physicians involved in the management of patients with chronic non-cancer pain (CNCP) have been introduced in clinical s...

    Authors: Katya Peri, Lucy Honeycutt, Erica Wennberg, Sarah B. Windle, Kristian B. Filion, Genevieve Gore, Irina Kudrina, Elena Paraskevopoulos, Areesha Moiz, Marc O. Martel and Mark J. Eisenberg
    Citation: BMC Medicine 2024 22:76
  31. Immune checkpoint inhibitors (ICIs) have transformed tumor treatment. However, the risk of pulmonary adverse events (PAEs) associated with ICI combination therapy is still unclear. We aimed to provide a PAE ov...

    Authors: Baohui Hong, Bin Du, Rong Chen, Caiyun Zheng, Ruping Ni, Maobai Liu and Jing Yang
    Citation: BMC Medicine 2024 22:75
  32. Neuregulin-1 (NRG1) is implicated in both cancer and neurologic diseases such as amyotrophic lateral sclerosis (ALS); however, to date, there has been little cross-field discussion between neurology and oncolo...

    Authors: Jacob J. Adashek, Chinmayi Pandya, Nicholas J. Maragakis, Pradip De, Philip R. Cohen, Shumei Kato and Razelle Kurzrock
    Citation: BMC Medicine 2024 22:74
  33. Annual screening through low-dose computed tomography (LDCT) is recommended for heavy smokers. However, it is questionable whether all individuals require annual screening given the potential harms of LDCT scr...

    Authors: Yin Liu, Huifang Xu, Lihong Lv, Xiaoyang Wang, Ruihua Kang, Xiaoli Guo, Hong Wang, Liyang Zheng, Hongwei Liu, Lanwei Guo, Qiong Chen, Shuzheng Liu, Youlin Qiao and Shaokai Zhang
    Citation: BMC Medicine 2024 22:73
  34. Authors: Roland von Känel, Mary Princip, Sarah A. Holzgang, Chrysoula Garefa, Alexia Rossi, Dominik C. Benz, Andreas A. Giannopoulos, Philipp A. Kaufmann, Ronny R. Buechel, Claudia Zuccarella-Hackl and Aju P. Pazhenkottil
    Citation: BMC Medicine 2024 22:71

    The original article was published in BMC Medicine 2023 21:477

  35. New 15- and 20-valent pneumococcal vaccines (PCV15, PCV20) are available for both children and adults, while PCV21 for adults is in development. However, their cost-effectiveness for older adults, taking into ...

    Authors: Pieter T. de Boer, Cornelis H. van Werkhoven, Albert Jan van Hoek, Mirjam J. Knol, Elisabeth A. M. Sanders, Jacco Wallinga, Hester E. de Melker and Anneke Steens
    Citation: BMC Medicine 2024 22:69
  36. Follow-up visits for very preterm infants (VPI) after hospital discharge is crucial for their neurodevelopmental trajectories, but ensuring their attendance before 12 months corrected age (CA) remains a challe...

    Authors: Hao Wei Chung, Ju-Chieh Chen, Hsiu-Lin Chen, Fang-Yu Ko and Shinn-Ying Ho
    Citation: BMC Medicine 2024 22:68
  37. Allergic diseases impose a significant global disease burden, however, the influence of light at night exposure on these diseases in humans has not been comprehensively assessed. We aimed to summarize availabl...

    Authors: Andy Deprato, Robert Maidstone, Anna Palomar Cros, Ana Adan, Prasun Haldar, Barbara N. Harding, Paige Lacy, Lyle Melenka, Saibal Moitra, José Francisco Navarro, Manolis Kogevinas, Hannah J Durrington and Subhabrata Moitra
    Citation: BMC Medicine 2024 22:67
  38. Despite many systematic reviews and meta-analyses examining the associations of pregnancy complications with risk of type 2 diabetes mellitus (T2DM) and hypertension, previous umbrella reviews have only examin...

    Authors: Steven Wambua, Megha Singh, Kelvin Okoth, Kym I. E. Snell, Richard D. Riley, Christopher Yau, Shakila Thangaratinam, Krishnarajah Nirantharakumar and Francesca L. Crowe
    Citation: BMC Medicine 2024 22:66
  39. Establishing whether there is a potential relationship between glucagon-like peptide 1 receptor agonists (GLP-1RAs) and suicidal or self-injurious behaviors (SSIBs) is crucial for public safety. This study inv...

    Authors: Jianxing Zhou, You Zheng, Baohua Xu, Songjun Long, Li-e Zhu, Yunhui Liu, Chengliang Li, Yifan Zhang, Maobai Liu and Xuemei Wu
    Citation: BMC Medicine 2024 22:65
  40. Effective pain control is crucial to optimise the success of medical procedures. Immersive virtual reality (VR) technology could offer an effective non-invasive, non-pharmacological option to distract patients...

    Authors: Jhia J. Teh, Dominic J. Pascoe, Safiya Hafeji, Rohini Parchure, Adam Koczoski, Michael P. Rimmer, Khalid S. Khan and Bassel H. Al Wattar
    Citation: BMC Medicine 2024 22:64
  41. Peripheral vertigo is often comorbid with psychiatric disorders. However, no longitudinal study has quantified the association between peripheral vertigo and risk of psychiatric disorders. Furthermore, it rema...

    Authors: Xiaowan Chen, Dang Wei, Fang Fang, Huan Song, Li Yin, Magnus Kaijser, Tiril Pedersen Gurholt, Ole Andreas Andreassen, Unnur Valdimarsdóttir, Kejia Hu and Maoli Duan
    Citation: BMC Medicine 2024 22:63
  42. The distal transradial access (dTRA) has become an attractive and alternative access to the conventional transradial access (TRA) for cardiovascular interventional diagnosis and/or treatment. There was a lack ...

    Authors: Tao Chen, Lamei Li, Feng Li, Wei Lu, Ganwei Shi, Wenhua Li, Anni Yang, Hui Huang, Jianqiang Xiao, Qiuwei Zhang, Jun Gu, Sheliang Xue, Liuyan Zhang, Li Li, Lingxia Xu, Rongrong Ji…
    Citation: BMC Medicine 2024 22:62
  43. Infective endocarditis (IE) following cardiac valve surgery is associated with high morbidity and mortality. Data on the impact of iatrogenic healthcare exposures on this risk are sparse. This study aimed to i...

    Authors: Timothy N. Kwan, David Brieger, Vincent Chow, Arnold Chin Tse Ng, Gemma Kwan, Karice Hyun, Raymond Sy, Leonard Kritharides and Austin Chin Chwan Ng
    Citation: BMC Medicine 2024 22:61
  44. In this commentary, we address a paper published by Johnson et al. by assessing the robustness of their method to discover diagnostic biomarkers in Alzheimer’s disease (AD). In addition, we examine how these n...

    Authors: Miyo K. Chatanaka, Ioannis Prassas and Eleftherios P. Diamandis
    Citation: BMC Medicine 2024 22:60
  45. Adverse childhood experiences (ACEs), including childhood maltreatment, have been linked with increased risk of diabetes and obesity during adulthood. A comprehensive assessment on the associations between chi...

    Authors: Shu Wen, Jianwei Zhu, Xin Han, Yuchen Li, Haowen Liu, Huazhen Yang, Can Hou, Shishi Xu, Junren Wang, Yao Hu, Yuanyuan Qu, Di Liu, Thor Aspelund, Fang Fang, Unnur A. Valdimarsdóttir and Huan Song
    Citation: BMC Medicine 2024 22:59
  46. The co-design of health care enables patient-centredness by partnering patients, clinicians and other stakeholders together to create services.

    Authors: Jennifer Sumner, Celeste Wen Ting Ng, Kimberly Ee Lin Teo, Adena Li Tyin Peh and Yee Wei Lim
    Citation: BMC Medicine 2024 22:58