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  1. Content type: Research article

    Risk prediction for patients with suspected coronary artery disease is complex due to the common occurrence of prior cardiovascular disease and extensive risk modification in primary care. Numerous markers hav...

    Authors: Dipak Kotecha, Marcus D. Flather, Dan Atar, Peter Collins, John Pepper, Elizabeth Jenkins, Christopher M. Reid and David Eccleston

    Citation: BMC Medicine 2019 17:72

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  2. Content type: Research article

    Peer support can enable patient engagement with healthcare services, particularly for marginalised populations. In this randomised controlled trial, the efficacy of a peer support intervention at promoting suc...

    Authors: Helen R. Stagg, Julian Surey, Marie Francis, Jennifer MacLellan, Graham R. Foster, André Charlett and Ibrahim Abubakar

    Citation: BMC Medicine 2019 17:71

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  3. Content type: Guideline

    There is a pressing need to understand better the extent and distribution of antimicrobial resistance on a global scale, to inform development of effective interventions. Collation of datasets for meta-analysi...

    Authors: Paul Turner, Andrew Fox-Lewis, Poojan Shrestha, David A. B. Dance, Tri Wangrangsimakul, Tomas-Paul Cusack, Clare L. Ling, Jill Hopkins, Tamalee Roberts, Direk Limmathurotsakul, Ben S. Cooper, Susanna Dunachie, Catrin E. Moore, Christiane Dolecek, H. Rogier van Doorn, Philippe J. Guerin…

    Citation: BMC Medicine 2019 17:70

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  4. Content type: Research article

    The most prevalent neglected tropical diseases are treated through blanket drug distribution that is reliant on lay community medicine distributors (CMDs). Yet, treatment rates achieved by CMDs vary widely and...

    Authors: Goylette F. Chami, Narcis B. Kabatereine and Edridah M. Tukahebwa

    Citation: BMC Medicine 2019 17:69

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  5. Content type: Forum

    Blockchain is a shared distributed digital ledger technology that can better facilitate data management, provenance and security, and has the potential to transform healthcare. Importantly, blockchain represen...

    Authors: Tim K. Mackey, Tsung-Ting Kuo, Basker Gummadi, Kevin A. Clauson, George Church, Dennis Grishin, Kamal Obbad, Robert Barkovich and Maria Palombini

    Citation: BMC Medicine 2019 17:68

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  6. Content type: Research article

    Statins may prevent recurrent ischemic events after ischemic stroke. Determining which statin to use remains controversial. We aimed to summarize the evidence for the use of statins in secondary prevention for...

    Authors: Irene Tramacere, Giorgio B. Boncoraglio, Rita Banzi, Cinzia Del Giovane, Koren H. Kwag, Alessandro Squizzato and Lorenzo Moja

    Citation: BMC Medicine 2019 17:67

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  7. Content type: Research article

    Pancreatic cancer (PaC) remains extremely lethal worldwide even after resection. PaC resection rates are low, making prognostic studies in resected PaC difficult. This large international population-based stud...

    Authors: Lei Huang, Yesilda Balavarca, Lydia van der Geest, Valery Lemmens, Liesbet Van Eycken, Harlinde De Schutter, Tom B. Johannesen, Vesna Zadnik, Maja Primic-Žakelj, Margit Mägi, Robert Grützmann, Marc G. Besselink, Petra Schrotz-King, Hermann Brenner and Lina Jansen

    Citation: BMC Medicine 2019 17:66

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  8. Content type: Research article

    Studies have shown that more than half of patients with advanced progressive diseases approaching the end-of-life report pain and that pain relief for these patients is poorest at home compared to other care s...

    Authors: Yousuf ElMokhallalati, Natalie Woodhouse, Tracey Farragher and Michael I. Bennett

    Citation: BMC Medicine 2019 17:50

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  9. Content type: Research article

    Depression symptom questionnaires are commonly used to assess symptom severity and as screening tools to identify patients who may have depression. They are not designed to ascertain diagnostic status and, bas...

    Authors: Brooke Levis, Xin Wei Yan, Chen He, Ying Sun, Andrea Benedetti and Brett D. Thombs

    Citation: BMC Medicine 2019 17:65

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  10. Content type: Review

    The growing body of evidence indicating the heterogeneity of Alzheimer’s disease (AD), coupled with disappointing clinical studies directed at a fit-for-all therapy, suggest that the development of a single ma...

    Authors: Mirna Safieh, Amos D. Korczyn and Daniel M. Michaelson

    Citation: BMC Medicine 2019 17:64

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  11. Content type: Research article

    The consumption of alcohol increases the risk of drinkers harming others. The extent of alcohol’s morbidity and mortality harms to others in Germany in 2014 was estimated for (1) fetal alcohol syndrome (FAS) o...

    Authors: Ludwig Kraus, Nicki-Nils Seitz, Kevin D. Shield, Gerrit Gmel and Jürgen Rehm

    Citation: BMC Medicine 2019 17:59

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  12. Content type: Correspondence

    There is growing appreciation that the success of digital health – whether digital tools, digital interventions or technology-based change strategies – is linked to the extent to which human factors are consid...

    Authors: Kit Huckvale, C. Jason Wang, Azeem Majeed and Josip Car

    Citation: BMC Medicine 2019 17:62

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  13. Content type: Research article

    Whether cognitive decline is related to a higher risk of death independent of the initial cognitive function is inconclusive. Evidence of the association between cognitive decline and mortality among Chinese o...

    Authors: Xiaozhen Lv, Wenyuan Li, Yuan Ma, Huashuai Chen, Yi Zeng, Xin Yu, Albert Hofman and Huali Wang

    Citation: BMC Medicine 2019 17:63

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  14. Content type: Research article

    There are over 200 million reported cases of malaria each year, and most children living in endemic areas will experience multiple episodes of clinical disease before puberty. We set out to understand how freq...

    Authors: Yaw Bediako, Rhys Adams, Adam J. Reid, John Joseph Valletta, Francis M. Ndungu, Jan Sodenkamp, Jedidah Mwacharo, Joyce Mwongeli Ngoi, Domtila Kimani, Oscar Kai, Juliana Wambua, George Nyangweso, Etienne P. de Villiers, Mandy Sanders, Magda Ewa Lotkowska, Jing-Wen Lin…

    Citation: BMC Medicine 2019 17:60

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  15. Content type: Research article

    Between August and December 2017, more than 625,000 Rohingya from Myanmar fled into Bangladesh, settling in informal makeshift camps in Cox’s Bazar district and joining 212,000 Rohingya already present. In ear...

    Authors: Flavio Finger, Sebastian Funk, Kate White, M. Ruby Siddiqui, W. John Edmunds and Adam J. Kucharski

    Citation: BMC Medicine 2019 17:58

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  16. Content type: Research article

    Herpes simplex virus type 1 (HSV-1) is a prevalent lifelong infection that appears to be undergoing an epidemiologic transition in the United States (US). Using an analytical approach, this study aimed to char...

    Authors: Houssein H. Ayoub, Hiam Chemaitelly and Laith J. Abu-Raddad

    Citation: BMC Medicine 2019 17:57

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  17. Content type: Research article

    Girl child marriage, a formal union of a female before age 18, and undernutrition remain common in Sub-Saharan Africa. The aim of this study is to establish the extent to which girl child marriage contributes ...

    Authors: Yvette Efevbera, Jacqueline Bhabha, Paul Farmer and Günther Fink

    Citation: BMC Medicine 2019 17:55

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  18. Content type: Research article

    Paediatric fever is a common cause of emergency department (ED) attendance. A lack of prompt and definitive diagnostics makes it difficult to distinguish viral from potentially life-threatening bacterial cause...

    Authors: Simon Leigh, Alison Grant, Nicola Murray, Brian Faragher, Henal Desai, Samantha Dolan, Naeema Cabdi, James B. Murray, Yasmin Rejaei, Stephanie Stewart, Karl Edwardson, Jason Dean, Bimal Mehta, Shunmay Yeung, Frans Coenen, Louis W. Niessen…

    Citation: BMC Medicine 2019 17:48

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  19. Content type: Research article

    Managing hearing communication for residents living with hearing loss and dementia in long-term care settings is challenging. This paper explores how care can be effective in optimising hearing communication f...

    Authors: Brian Crosbie, Melanie Ferguson, Geoff Wong, Dawn-Marie Walker, Stevie Vanhegan and Tom Dening

    Citation: BMC Medicine 2019 17:54

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  20. Content type: Correction

    The original article [1] contains a minor error whereby the dates for year of first launch and year of first report of adverse reaction for iophendylate in e-Appendix Table 1 are mistakenly presented as 1946 a...

    Authors: Igho J. Onakpoya, Carl J. Heneghan and Jeffrey K. Aronson

    Citation: BMC Medicine 2019 17:56

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    The original article was published in BMC Medicine 2016 14:10

  21. Content type: Research article

    Guidelines recommend that clinicians should make brief opportunistic behavioural interventions to patients who are obese to increase the uptake of effective weight loss programmes. The objective was to assess ...

    Authors: J. Graham, K. Tudor, S. A. Jebb, A. Lewis, S. Tearne, P. Adab, R. Begh, K. Jolly, A. Daley, A. Farley, D. Lycett, A. Nickless and P. Aveyard

    Citation: BMC Medicine 2019 17:51

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  22. Content type: Research article

    Falls are the leading cause of fatal and non-fatal unintentional injuries in older people. The use of Exergames (active, gamified video-based exercises) is a possible innovative, community-based approach. This...

    Authors: Emma K. Stanmore, Alexandra Mavroeidi, Lex D. de Jong, Dawn A. Skelton, Chris J. Sutton, Valerio Benedetto, Luke A. Munford, Wytske Meekes, Vicky Bell and Chris Todd

    Citation: BMC Medicine 2019 17:49

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  23. Content type: Opinion

    The concept of reserve was established to account for the observation that a given degree of neurodegenerative pathology may result in varying degrees of symptoms in different individuals. There is a large amo...

    Authors: Robert Perneczky, Gerd Kempermann, Amos D. Korczyn, Fiona E. Matthews, M. Arfan Ikram, Nikolaos Scarmeas, Gael Chetelat, Yaakov Stern and Michael Ewers

    Citation: BMC Medicine 2019 17:47

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  24. Content type: Research article

    Leading malaria vaccine, RTS,S, is based on the circumsporozoite protein (CSP) of sporozoites. RTS,S confers partial protection against malaria in children, but efficacy wanes relatively quickly after primary ...

    Authors: Liriye Kurtovic, Paul A. Agius, Gaoqian Feng, Damien R. Drew, Itziar Ubillos, Jahit Sacarlal, John J. Aponte, Freya J. I. Fowkes, Carlota Dobaño and James G. Beeson

    Citation: BMC Medicine 2019 17:45

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  25. Content type: Research article

    Adopting clinical genomics represents a major systems-level intervention requiring diverse expertise and collective learning. The Australian Genomic Health Alliance (Australian Genomics) is strategically linki...

    Authors: Janet C. Long, Chiara Pomare, Stephanie Best, Tiffany Boughtwood, Kathryn North, Louise A. Ellis, Kate Churruca and Jeffrey Braithwaite

    Citation: BMC Medicine 2019 17:44

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  26. Content type: Research article

    Sustainable Development Goals set a challenge for the elimination of hepatitis B virus (HBV) infection as a public health concern by the year 2030. Deployment of a robust prophylactic vaccine and enhanced inte...

    Authors: Anna L. McNaughton, José Lourenço, Louise Hattingh, Emily Adland, Samantha Daniels, Anriette Van Zyl, Connie S. Akiror, Susan Wareing, Katie Jeffery, M. Azim Ansari, Paul Klenerman, Philip J. R. Goulder, Sunetra Gupta, Pieter Jooste and Philippa C. Matthews

    Citation: BMC Medicine 2019 17:43

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  27. Content type: Research article

    Cathelicidins are a major group of natural antimicrobial peptides which play essential roles in regulating host defense and immunity. In addition to the antimicrobial and immunomodulatory activities, recent st...

    Authors: Yihua Bei, Li-Long Pan, Qiulian Zhou, Cuimei Zhao, Yuan Xie, Chengfei Wu, Xiangmin Meng, Huanyu Gu, Jiahong Xu, Lei Zhou, Joost P. G. Sluijter, Saumya Das, Birgitta Agerberth, Jia Sun and Junjie Xiao

    Citation: BMC Medicine 2019 17:42

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  28. Content type: Research article

    Recently, euthanasia and assisted suicide (EAS) in patients with psychiatric disorders, dementia, or an accumulation of health problems has taken a prominent place in the public debate. However, limited is kno...

    Authors: Kirsten Evenblij, H. Roeline W. Pasman, Agnes van der Heide, Trynke Hoekstra and Bregje D. Onwuteaka-Philipsen

    Citation: BMC Medicine 2019 17:39

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  29. Content type: Research article

    Thymic size in early infancy predicts subsequent survival in low-income settings. The human thymus develops from early gestation, is most active in early life and is highly sensitive to malnutrition. Our objec...

    Authors: Sophie E. Moore, Anthony J. C. Fulford, Fatou Sosseh, Patrick Nshe, Momodou K. Darboe and Andrew M. Prentice

    Citation: BMC Medicine 2019 17:38

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  30. Content type: Correction

    The original article [1] contained two minor errors.

    Authors: Michael Berk, Alyna Turner, Gin S. Malhi, Chee H. Ng, Susan M. Cotton, Seetal Dodd, Yuval Samuni, Michelle Tanious, Claire McAulay, Nathan Dowling, Jerome Sarris, Lauren Owen, Astrid Waterdrinker, Deidre Smith and Olivia M. Dean

    Citation: BMC Medicine 2019 17:35

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    The original article was published in BMC Medicine 2019 17:18

  31. Content type: Research article

    Researchers have long recognized that stigma is a global, multi-level phenomenon requiring intervention approaches that target multiple levels including individual, interpersonal, community, and structural lev...

    Authors: Deepa Rao, Ahmed Elshafei, Minh Nguyen, Mark L. Hatzenbuehler, Sarah Frey and Vivian F. Go

    Citation: BMC Medicine 2019 17:41

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  32. Content type: Correspondence

    Stigma is a well-documented barrier to health seeking behavior, engagement in care and adherence to treatment across a range of health conditions globally. In order to halt the stigmatization process and mitig...

    Authors: Anne L. Stangl, Valerie A. Earnshaw, Carmen H. Logie, Wim van Brakel, Leickness C. Simbayi, Iman Barré and John F. Dovidio

    Citation: BMC Medicine 2019 17:31

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  33. Content type: Correspondence

    Stigma in health facilities undermines diagnosis, treatment, and successful health outcomes. Addressing stigma is fundamental to delivering quality healthcare and achieving optimal health. This correspondence ...

    Authors: Laura Nyblade, Melissa A. Stockton, Kayla Giger, Virginia Bond, Maria L. Ekstrand, Roger Mc Lean, Ellen M. H. Mitchell, La Ron E. Nelson, Jaime C. Sapag, Taweesap Siraprapasiri, Janet Turan and Edwin Wouters

    Citation: BMC Medicine 2019 17:25

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  34. Content type: Research article

    Stigma is associated with health conditions that drive disease burden in low- and middle-income countries (LMICs), including HIV, tuberculosis, mental health problems, epilepsy, and substance use disorders. Ho...

    Authors: Jeremy C. Kane, Melissa A. Elafros, Sarah M. Murray, Ellen M. H. Mitchell, Jura L. Augustinavicius, Sara Causevic and Stefan D. Baral

    Citation: BMC Medicine 2019 17:17

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  35. Content type: Opinion

    Many health conditions perceived to be contagious, dangerous or incurable, or resulting in clearly visible signs, share a common attribute – an association with stigma and discrimination. While the etiology of...

    Authors: Wim H. van Brakel, Janine Cataldo, Sandeep Grover, Brandon A. Kohrt, Laura Nyblade, Melissa Stockton, Edwin Wouters and Lawrence H. Yang

    Citation: BMC Medicine 2019 17:13

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  36. Content type: Correspondence

    ‘Intersectional stigma’ is a concept that has emerged to characterize the convergence of multiple stigmatized identities within a person or group, and to address their joint effects on health and wellbeing. Wh...

    Authors: Janet M. Turan, Melissa A. Elafros, Carmen H. Logie, Swagata Banik, Bulent Turan, Kaylee B. Crockett, Bernice Pescosolido and Sarah M. Murray

    Citation: BMC Medicine 2019 17:7

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  37. Content type: Research article

    Interventions to alleviate stigma are demonstrating effectiveness across a range of conditions, though few move beyond the pilot phase, especially in low- and middle-income countries (LMICs). Implementation sc...

    Authors: Christopher G. Kemp, Brooke A. Jarrett, Churl-Su Kwon, Lanxin Song, Nathalie Jetté, Jaime C. Sapag, Judith Bass, Laura Murray, Deepa Rao and Stefan Baral

    Citation: BMC Medicine 2019 17:6

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  38. Content type: Research article

    High-throughput non-invasive prenatal testing (NIPT) for fetal Rhesus D (RhD) status could avoid unnecessary treatment with anti-D immunoglobulin for RhD-negative women found to be carrying an RhD-negative fet...

    Authors: Huiqin Yang, Alexis Llewellyn, Ruth Walker, Melissa Harden, Pedro Saramago, Susan Griffin and Mark Simmonds

    Citation: BMC Medicine 2019 17:37

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  39. Content type: Research article

    Financial risk protection (FRP) is a key objective of national health systems and a core pillar of universal health coverage (UHC). Yet, little is known about the disease-specific distribution of catastrophic ...

    Authors: Annie Haakenstad, Matthew Coates, Andrew Marx, Gene Bukhman and Stéphane Verguet

    Citation: BMC Medicine 2019 17:36

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  40. Content type: Research article

    In 2012, the UK introduced medical revalidation, whereby to retain their licence all doctors are required to show periodically that they are up to date and fit to practise medicine. Early reports suggested tha...

    Authors: Nils Gutacker, Karen Bloor, Chris Bojke, Julian Archer and Kieran Walshe

    Citation: BMC Medicine 2019 17:33

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  41. Content type: Research article

    Almost all countries without complete vital registration systems have data on deaths collected by hospitals. However, these data have not been widely used to estimate cause of death (COD) patterns in populatio...

    Authors: Gail M. Williams, Ian Douglas Riley, Riley H. Hazard, Hafizur R. Chowhury, Nurul Alam, Peter Kim Streafield, Veronica Tallo, Diozele Sanvictores, Marilla Lucero, Tim Adair and Alan D. Lopez

    Citation: BMC Medicine 2019 17:29

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  42. Content type: Research article

    The India Newborn Action Plan (INAP) aims for < 10 stillbirths per 1000 births by 2030. A population-based understanding of risk factors for stillbirths compared with live births that could assist with reducti...

    Authors: Rakhi Dandona, G. Anil Kumar, Md. Akbar, Debarshi Bhattacharya, Priya Nanda and Lalit Dandona

    Citation: BMC Medicine 2019 17:28

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