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  1. We test a novel ‘weight scarring’ hypothesis which suggests that past obesity is associated with impairments in current psychological well-being and this increases risk of negative physical health outcomes ass...

    Authors: I Gusti Ngurah Edi Putra, Michael Daly, Angelina Sutin, Andrew Steptoe and Eric Robinson
    Citation: BMC Medicine 2023 21:448
  2. Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are closely related and mutually contribute to the disease’s development. There are many treatment options available to patients. We...

    Authors: Manjun Deng, Yonghao Wen, JingXin Yan, Yichen Fan, Zhixin Wang, Ruixia Zhang, Li Ren, Yinggui Ba, Haijiu Wang, Qian Lu and Haining Fan
    Citation: BMC Medicine 2023 21:447
  3. Vulnerable older adults living with Alzheimer’s disease or Alzheimer’s disease and related dementia (AD/ADRD) and chronic pain generally receive fewer pain medications than individuals without AD/ADRD, especia...

    Authors: Ulrike Muench, Kyung Mi Kim, Zachary Zimmer and Todd B. Monroe
    Citation: BMC Medicine 2023 21:446
  4. Metabolite signatures of long-term alcohol consumption are lacking. To better understand the molecular basis linking alcohol drinking and cardiovascular disease (CVD), we investigated circulating metabolites a...

    Authors: Yi Li, Mengyao Wang, Xue Liu, Jian Rong, Patricia Emogene Miller, Roby Joehanes, Tianxiao Huan, Xiuqing Guo, Jerome I. Rotter, Jennifer A. Smith, Bing Yu, Matthew Nayor, Daniel Levy, Chunyu Liu and Jiantao Ma
    Citation: BMC Medicine 2023 21:443
  5. Waist-to-height ratio (WHtR) has been proposed as a simple and effective screening tool for assessing central obesity and cardiometabolic risk in both adult and pediatric populations. However, evidence suggest...

    Authors: Xin’nan Zong, Roya Kelishadi, Young Mi Hong, Peter Schwandt, Tandi E. Matsha, Jose G. Mill, Peter H. Whincup, Lucia Pacifico, Abel López-Bermejo, Carmelo Antonio Caserta, Carla Campos Muniz Medeiros, Anastasios Kollias, Mostafa Qorbani, Fariborz Sharifian Jazi, Gerda-Maria Haas, Rafael de Oliveira Alvim…
    Citation: BMC Medicine 2023 21:442
  6. Large-scale prevention of respiratory syncytial virus (RSV) infection may have ecological consequences for co-circulating pathogens, including influenza. We assessed if and for how long RSV infection alters th...

    Authors: Naomi R. Waterlow, Jackie Kleynhans, Nicole Wolter, Stefano Tempia, Rosalind M. Eggo, Orienka Hellferscee, Limakatso Lebina, Neil Martinson, Ryan G. Wagner, Jocelyn Moyes, Anne von Gottberg, Cheryl Cohen and Stefan Flasche
    Citation: BMC Medicine 2023 21:441
  7. Creatine is an organic compound that facilitates the recycling of energy-providing adenosine triphosphate (ATP) in muscle and brain tissue. It is a safe, well-studied supplement for strength training. Previous...

    Authors: Julia Fabienne Sandkühler, Xenia Kersting, Annika Faust, Eva Kathrin Königs, George Altman, Ulrich Ettinger, Silke Lux, Alexandra Philipsen, Helge Müller and Jan Brauner
    Citation: BMC Medicine 2023 21:440
  8. Marburg virus disease is an acute haemorrhagic fever caused by Marburg virus. Marburg virus is zoonotic, maintained in nature in Egyptian fruit bats, with occasional spillover infections into humans and nonhum...

    Authors: George Y. Qian, W. John Edmunds, Daniel G. Bausch and Thibaut Jombart
    Citation: BMC Medicine 2023 21:439
  9. Breast cancer is the most commonly diagnosed cancer in women worldwide, and underlying mechanistic pathways associated with breast cancer-specific and non-breast cancer-related deaths are of importance. Emergi...

    Authors: Nina Sophia Decker, Theron Johnson, Johannes A. Vey, Charlotte Le Cornet, Sabine Behrens, Nadia Obi, Rudolf Kaaks, Jenny Chang-Claude and Renée Turzanski Fortner
    Citation: BMC Medicine 2023 21:438
  10. People with hypertension have a higher risk of developing Parkinson’s disease (PD), epidemiological evidence suggests that multiple antihypertensives may affect the occurrence and development of PD with incons...

    Authors: Zeying Feng, Qiuping Zhao, Jingjing Wu, Yiping Yang, Xinru Jia, Junlong Ma, Haibo Tang, Hong Yuan, Guoping Yang and Yao Lu
    Citation: BMC Medicine 2023 21:437
  11. Metabolically healthy obesity is hypothesized to be a benign condition but whether this is the case for dementia remains debated. We examined the role of age at assessment of metabolic-obesity phenotypes in as...

    Authors: Marcos D. Machado-Fragua, Séverine Sabia, Aurore Fayosse, Céline Ben Hassen, Frank van der Heide, Mika Kivimaki and Archana Singh-Manoux
    Citation: BMC Medicine 2023 21:436
  12. Infants born very and extremely premature (V/EPT) are at a significantly elevated risk for neurodevelopmental disorders and delays even in the absence of structural brain injuries. These risks may be due to ea...

    Authors: Kevin M. Cook, Josepheen De Asis-Cruz, Jung-Hoon Kim, Sudeepta K. Basu, Nickie Andescavage, Jonathan Murnick, Emma Spoehr, Melissa Liggett, Adré J. du Plessis and Catherine Limperopoulos
    Citation: BMC Medicine 2023 21:435
  13. The widening of group-level socioeconomic differences in body mass index (BMI) has received considerable research attention. However, the predictive power of socioeconomic position (SEP) indicators at the indi...

    Authors: Liam Wright, Charis Bridger Staatz, Richard J. Silverwood and David Bann
    Citation: BMC Medicine 2023 21:434
  14. Genetics play an important role in risk for cardiometabolic diseases—including type 2 diabetes, cardiovascular disease and obesity. Existing research has explored the clinical utility of genetic risk tools suc...

    Authors: Jing Hui Law, Najia Sultan, Sarah Finer and Nina Fudge
    Citation: BMC Medicine 2023 21:432
  15. Elevated standardised mortality ratio of cardiovascular diseases (CVD) in patients with brain tumours may result from differences in the CVD incidences and cardiovascular risk factors. We compared the risk of ...

    Authors: Michael T. C. Poon, Paul M. Brennan, Kai Jin, Cathie L. M. Sudlow and Jonine D. Figueroa
    Citation: BMC Medicine 2023 21:431
  16. Recent studies have highlighted the role of low-grade systemic inflammation in linking periodontitis to cardiovascular disease (CVD) outcomes, but many aspects remain unclear. This study examines the independe...

    Authors: Christiane Pink, Birte Holtfreter, Henry Völzke, Matthias Nauck, Marcus Dörr and Thomas Kocher
    Citation: BMC Medicine 2023 21:430
  17. Vaccination has played a pivotal role in reducing the burden of COVID-19. Despite numerous studies highlighting its benefits in reducing the risk of severe disease and death, we still lack a quantitative under...

    Authors: Mahan Ghafari, Sepanta Hosseinpour, Mohammad Saeid Rezaee-Zavareh, Stefan Dascalu, Somayeh Rostamian, Kiarash Aramesh, Kaveh Madani and Shahram Kordasti
    Citation: BMC Medicine 2023 21:429
  18. Components of social connection are associated with mortality, but research examining their independent and combined effects in the same dataset is lacking. This study aimed to examine the independent and comb...

    Authors: Hamish M. E. Foster, Jason M. R. Gill, Frances S. Mair, Carlos A. Celis-Morales, Bhautesh D. Jani, Barbara I. Nicholl, Duncan Lee and Catherine A. O’Donnell
    Citation: BMC Medicine 2023 21:384
  19. Research on the association between telomere length (TL) and incident non-alcoholic fatty liver disease (NAFLD) is limited. This study examined this association and further assessed how TL contributes to the a...

    Authors: Linxi Tang, Dankang Li, Yudiyang Ma, Feipeng Cui, Jianing Wang and Yaohua Tian
    Citation: BMC Medicine 2023 21:427
  20. Given the widespread implementation of COVID-19 vaccination to mitigate the pandemic from the end of 2020, it is important to retrospectively evaluate its impact, in particular by quantifying the number of sev...

    Authors: Laetitia Tan-Lhernould, Cynthia Tamandjou, Guilhem Deschamps, Johnny Platon, Cécile Sommen, Fanny Chereau, Isabelle Parent du Châtelet, Simon Cauchemez, Sophie Vaux and Juliette Paireau
    Citation: BMC Medicine 2023 21:426
  21. People need high-quality information to make decisions about research participation. Providing information in written format alone is conventional but may not be the most effective and acceptable approach. We ...

    Authors: Vichithranie W. Madurasinghe, Peter Knapp, Sandra Eldridge, David Collier, Shaun Treweek, Jo Rick, Jonathan Graffy, Adwoa Parker, Chris Salisbury, David Torgerson, Kate Jolly, Manbinder S. Sidhu, Christopher Fife-Schaw, Mark A. Hull, Kirsty Sprange, Elizabeth Brettell…
    Citation: BMC Medicine 2023 21:425
  22. Antidepressants are licensed for use in depressive disorders, but non-response and poor adherence to treatment affect a considerable number of patients. Pre-clinical and clinical evidence suggest that statins ...

    Authors: Riccardo De Giorgi, Franco De Crescenzo, Philip J. Cowen, Catherine J. Harmer and Andrea Cipriani
    Citation: BMC Medicine 2023 21:424
  23. Treatment options beyond the first-line setting for recurrent or metastatic nasopharyngeal carcinoma (RM-NPC) are limited. The role of the multitarget tyrosine kinase inhibitor anlotinib in RM-NPC is unclear.

    Authors: Yu Fang, Ning Su, Qihua Zou, Yi Cao, Yi Xia, Linquan Tang, Xiaopeng Tian, Panpan Liu and Qingqing Cai
    Citation: BMC Medicine 2023 21:423
  24. Maternal pre-gestational diabetes (PGDM), gestational diabetes mellitus (GDM), and overweight/obesity have been associated with increased risks of offspring neurodevelopmental conditions (NDCs) including autis...

    Authors: Shuyun Chen, Xi Wang, Brian K. Lee and Renee M. Gardner
    Citation: BMC Medicine 2023 21:422
  25. Reactive astrogliosis has been demonstrated to have a role in Parkinson’s disease (PD); however, astrocyte-specific plasma glial fibrillary acidic protein (GFAP)’s correlation with PD progression remains unkno...

    Authors: Junyu Lin, Ruwei Ou, Chunyu Li, Yanbing Hou, Lingyu Zhang, Qianqian Wei, Dejiang Pang, Kuncheng Liu, Qirui Jiang, Tianmi Yang, Yi Xiao, Bi Zhao, Xueping Chen, Wei Song, Jing Yang, Ying Wu…
    Citation: BMC Medicine 2023 21:420
  26. Accumulating evidence has suggested an oncogenic effect of diurnal disruption on cancer progression. To test whether targeting circadian rhythm by dietary strategy suppressed lung cancer progression, we adopte...

    Authors: Dan Shi, Gaofeng Fang, Qianyao Chen, Jianling Li, Xiongzhong Ruan and Xuemei Lian
    Citation: BMC Medicine 2023 21:417
  27. Progressive reduction of sodium intake is an attractive approach for addressing excessive salt intake, but evidence for this strategy in real practice is limited. We aimed to determine the feasibility, effecti...

    Authors: Yifang Yuan, Aoming Jin, Peifen Duan, La’e Cao, Hongxia Wang, Senke Hu, Jiayu Li, Xiangxian Feng, Qianku Qiao, Hui Zhang, Ruijuan Zhang, Huijuan Li, Pei Gao, Gaoqiang Xie, Jianhui Yuan, Lili Cheng…
    Citation: BMC Medicine 2023 21:416
  28. Sepsis is characterized by a dysregulated immune response and metabolic alterations, including decreased high-density lipoprotein cholesterol (HDL-C) levels. HDL exhibits beneficial properties, such as lipopol...

    Authors: Alessandra Stasi, Marco Fiorentino, Rossana Franzin, Francesco Staffieri, Sabrina Carparelli, Rosa Losapio, Alberto Crovace, Luca Lacitignola, Maria Teresa Cimmarusti, Francesco Murgolo, Monica Stufano, Cesira Cafiero, Giuseppe Castellano, Fabio Sallustio, Chiara Ferrari, Mario Ribezzi…
    Citation: BMC Medicine 2023 21:392
  29. The early life stage is critical for the gut microbiota establishment and development. We aimed to investigate the lifelong impact of famine exposure during early life on the adult gut microbial ecosystem and ...

    Authors: Wanglong Gou, Huijun Wang, Xin-yi Tang, Yan He, Chang Su, Jiguo Zhang, Ting-yu Sun, Zengliang Jiang, Zelei Miao, Yuanqing Fu, Hui Zhao, Yu-ming Chen, Bing Zhang, Hongwei Zhou and Ju-Sheng Zheng
    Citation: BMC Medicine 2023 21:414
  30. Antenatal corticosteroids are considered the standard of care for pregnant women at risk for preterm birth, but studies examining their potential risks are scarce. We aimed to estimate the associations of ante...

    Authors: Hui-Ju Tsai, Beth I. Wallace, Akbar K. Waljee, Xiumei Hong, Sheng-Mao Chang, Yi-Fen Tsai, Mei-Leng Cheong, Ann Chen Wu and Tsung-Chieh Yao
    Citation: BMC Medicine 2023 21:413
  31. Cardiac fibrosis is one of the top killers among fibrotic diseases and continues to be a global unaddressed health problem. The lack of effective treatment combined with the considerable socioeconomic burden h...

    Authors: Milena Paw, Agnieszka A. Kusiak, Kinga Nit, Jacek J. Litewka, Marcin Piejko, Dawid Wnuk, Michał Sarna, Kinga Fic, Kinga B. Stopa, Ruba Hammad, Olga Barczyk-Woznicka, Toni Cathomen, Ewa Zuba-Surma, Zbigniew Madeja, Paweł E. Ferdek and Sylwia Bobis-Wozowicz
    Citation: BMC Medicine 2023 21:412
  32. Sedentary behavior and vitamin D deficiency are independent risk factors for mortality in cancer survivors, but their joint association with mortality has not been investigated.

    Authors: Yu Yu, Sijing Cheng, Hao Huang, Yu Deng, Chi Cai, Min Gu, Xuhua Chen, Hongxia Niu and Wei Hua
    Citation: BMC Medicine 2023 21:411
  33. With increasing hypercholesterolemia prevalence in East Asian adolescents, pharmacologic interventions (e.g., HMGCR inhibitors (statins) and PCSK9 inhibitors) may have to be considered although their longer-te...

    Authors: Shan Luo, Hugh Simon Lam, Yap Hang Chan, Clara Sze Man Tang, Baoting He, Man Ki Kwok, Gabriel M. Leung, C Mary Schooling and Shiu Lun Au Yeung
    Citation: BMC Medicine 2023 21:410
  34. The gut mycobiome of patients with lung adenocarcinoma (LUAD) remains unexplored. This study aimed to characterize the gut mycobiome in patients with LUAD and evaluate the potential of gut fungi as non-invasiv...

    Authors: Qingyan Liu, Weidong Zhang, Yanbin Pei, Haitao Tao, Junxun Ma, Rong Li, Fan Zhang, Lijie Wang, Leilei Shen, Yang Liu, Xiaodong Jia and Yi Hu
    Citation: BMC Medicine 2023 21:409
  35. Black Americans suffer disparities in risk for cardiometabolic and other chronic diseases. Findings from the Adventist Health Study-2 (AHS-2) cohort have shown associations of plant-based dietary patterns and ...

    Authors: Fayth M. Butler, Jason Utt, Roy O. Mathew, Carlos A. Casiano, Suzanne Montgomery, Seth A. Wiafe, Johanna W. Lampe and Gary E. Fraser
    Citation: BMC Medicine 2023 21:408
  36. Unprofessional behaviour (UB) between staff encompasses various behaviours, including incivility, microaggressions, harassment, and bullying. UB is pervasive in acute healthcare settings and disproportionately...

    Authors: Jill Maben, Justin Avery Aunger, Ruth Abrams, Judy M. Wright, Mark Pearson, Johanna I. Westbrook, Aled Jones and Russell Mannion
    Citation: BMC Medicine 2023 21:403
  37. The aim of this study was to forecast future patient demand for shoulder replacement surgery in England and investigate any geographic and socioeconomic inequalities in service provision and patient outcomes.

    Authors: Epaminondas Markos Valsamis, Rafael Pinedo-Villanueva, Adrian Sayers, Gary S. Collins and Jonathan L. Rees
    Citation: BMC Medicine 2023 21:406
  38. Most of superficial soft-tissue masses are benign tumors, and very few are malignant tumors. However, persistent growth, of both benign and malignant tumors, can be painful and even life-threatening. It is nec...

    Authors: Bin Long, Haoyan Zhang, Han Zhang, Wen Chen, Yang Sun, Rui Tang, Yuxuan Lin, Qiang Fu, Xin Yang, Ligang Cui and Kun Wang
    Citation: BMC Medicine 2023 21:405
  39. Prostate cancer (PCa) is the most common malignancy diagnosed in men. Immune checkpoint blockade (ICB) alone showed disappointing results in PCa. It is partly due to the formation of immunosuppressive tumor mi...

    Authors: Zude Chen, Xiaoshuang Yang, Zugen Chen, Minzhao Li, Wei Wang, Riwei Yang, Zuomin Wang, Yuxiang Ma, Yulong Xu, Shan Ao, Leqi Liang, Chao Cai, Changning Wang, Tuo Deng, Di Gu, Hongqing Zhou…
    Citation: BMC Medicine 2023 21:402
  40. Authors: Annelieke R. Müller, Michiel A. J. Luijten, Lotte Haverman, Wendela L. de Ranitz-Greven, Peter Janssens, André B. Rietman, Leontine W.ten Hoopen, Laura C. G. de Graaff, Marie-Claire de Wit, Anna C. Jansen, Tanjala Gipson, Jamie K. Capal, Petrus J. de Vries and Agnies M. van Eeghen
    Citation: BMC Medicine 2023 21:401

    The original article was published in BMC Medicine 2023 21:298

  41. Data sharing is essential for promoting scientific discoveries and informed decision-making in clinical practice. In 2013, PhRMA/EFPIA recognised the importance of data sharing and supported initiatives to enh...

    Authors: Natansh D. Modi, Ganessan Kichenadasse, Tammy C. Hoffmann, Mark Haseloff, Jessica M. Logan, Areti A. Veroniki, Rebecca L. Venchiarutti, Amelia K. Smit, Haitham Tuffaha, Harindra Jayasekara, Arkady Manning-Bennet, Erin Morton, Ross A. McKinnon, Andrew Rowland, Michael J. Sorich and Ashley M. Hopkins
    Citation: BMC Medicine 2023 21:400
  42. We aimed to model total charges for the most prevalent multimorbidity combinations in the USA and assess model accuracy across Asian/Pacific Islander, African American, Biracial, Caucasian, Hispanic, and Nativ...

    Authors: Manal Alshakhs, Patricia J. Goedecke, James E. Bailey and Charisse Madlock-Brown
    Citation: BMC Medicine 2023 21:399
  43. Single low-dose primaquine (SLDPQ) effectively blocks the transmission of Plasmodium falciparum malaria, but anxiety remains regarding its haemolytic potential in patients with glucose-6-phopshate dehydrogenase (...

    Authors: Marie A. Onyamboko, Peter Olupot-Olupot, Winifred Were, Cate Namayanja, Peter Onyas, Harriet Titin, Joy Baseke, Rita Muhindo, Daddy K. Kayembe, Pauline O. Ndjowo, Benjamin B. Basara, Charles B. Okalebo, Thomas N. Williams, Sophie Uyoga, Chiraporn Taya, Adeola Bamisaiye…
    Citation: BMC Medicine 2023 21:397
  44. Thoracic aortic dissection (TAD) is a life-threatening disease caused by an intimal tear in the aorta. The histological characteristics differ significantly between the tear area (TA) and the distant area. Pre...

    Authors: Yixuan Sheng, Liying Wu, Yuan Chang, Wendao Liu, Menghao Tao, Xiao Chen, Xiong Zhang, Bin Li, Ningning Zhang, Dongting Ye, Chunxi Zhang, Daliang Zhu, Haisen Zhao, Aijun Chen, Haisheng Chen and Jiangping Song
    Citation: BMC Medicine 2023 21:396
  45. GT90001 (also known as PF-03446962) is an anti-ALK-1 monoclonal antibody and has shown activity in hepatocellular carcinoma (HCC). This phase 1b/2 study was designed to determine the recommended phase 2 dose (...

    Authors: Chiun Hsu, Yi-Fang Chang, Chia-Jui Yen, Yu-Wei Xu, Min Dong and You-Zhi Tong
    Citation: BMC Medicine 2023 21:395
  46. Previous studies that assessed the risk of cardiovascular outcomes in survivors of coronavirus disease 2019 (COVID-19) were likely limited by lack of generalizability and selection of controls nonrepresentativ...

    Authors: Min-Taek Lee, Moon Seong Baek, Tae Wan Kim, Sun-Young Jung and Won-Young Kim
    Citation: BMC Medicine 2023 21:394