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  1. The majority of Plasmodium falciparum malaria cases in Africa are treated with the artemisinin combination therapies artemether-lumefantrine (AL) and artesunate-amodiaquine (AS-AQ), with amodiaquine being also wi...

    Authors: Michael T. Bretscher, Prabin Dahal, Jamie Griffin, Kasia Stepniewska, Quique Bassat, Elisabeth Baudin, Umberto D’Alessandro, Abdoulaye A. Djimde, Grant Dorsey, Emmanuelle Espié, Bakary Fofana, Raquel González, Elizabeth Juma, Corine Karema, Estrella Lasry, Bertrand Lell…

    Citation: BMC Medicine 2020 18:47

    Content type: Research article

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  2. Atypical Beijing genotype Mycobacterium tuberculosis strains are widespread in South Africa and have acquired resistance to up to 13 drugs on multiple occasions. It is puzzling that these strains have retained fi...

    Authors: Marisa Klopper, Tim Hermanus Heupink, Grant Hill-Cawthorne, Elizabeth Maria Streicher, Anzaan Dippenaar, Margaretha de Vos, Abdallah Musa Abdallah, Jason Limberis, Matthias Merker, Scott Burns, Stefan Niemann, Keertan Dheda, James Posey, Arnab Pain and Robin Mark Warren

    Citation: BMC Medicine 2020 18:24

    Content type: Research article

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  3. An acute episode of malaria can be followed by multiple recurrent episodes either due to re-infection, recrudescence of a partially treated parasite or, in the case of Plasmodium vivax or P. ovale, relapse from t...

    Authors: Saber Dini, Nicholas M. Douglas, Jeanne Rini Poespoprodjo, Enny Kenangalem, Paulus Sugiarto, Ian D. Plumb, Ric N. Price and Julie A. Simpson

    Citation: BMC Medicine 2020 18:28

    Content type: Research article

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  4. There is growing evidence that mental disorders behave like complex dynamic systems. Complex dynamic systems theory states that a slower recovery from small perturbations indicates a loss of resilience of a sy...

    Authors: Anna Kuranova, Sanne H. Booij, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Bart P. F. Rutten, Nele Jacobs, Jim van Os, Johanna T. W. Wigman and Marieke Wichers

    Citation: BMC Medicine 2020 18:36

    Content type: Research article

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  5. Dengue infection can cause a wide spectrum of clinical outcomes. The severe clinical manifestations occur sufficiently late in the disease course, during day 4–6 of illness, to allow a window of opportunity fo...

    Authors: Nguyen Lam Vuong, Huynh Thi Le Duyen, Phung Khanh Lam, Dong Thi Hoai Tam, Nguyen Van Vinh Chau, Nguyen Van Kinh, Ngoun Chanpheaktra, Lucy Chai See Lum, Ernesto Pleités, Nick Keith Jones, Cameron Paul Simmons, Kerstin Rosenberger, Thomas Jaenisch, Christine Halleux, Piero Luigi Olliaro, Bridget Wills…

    Citation: BMC Medicine 2020 18:35

    Content type: Research article

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  6. Cesarean section (CS) rate has risen dramatically and stayed at a very high level in China over the past two to three decades. Given the short- and long-term adverse effects of CS, effective strategies are nee...

    Authors: Lulu Zhang, Lin Zhang, Meng Li, Jie Xi, Xiaohua Zhang, Zhenni Meng, Ying Wang, Huaping Li, Xiaohua Liu, Feihua Ju, Yuping Lu, Huijun Tang, Xianju Qin, Yanhong Ming, Rong Huang, Guohong Li…

    Citation: BMC Medicine 2020 18:27

    Content type: Research article

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  7. Childhood maltreatment has been associated with significant impairment in social, emotional and behavioural functioning later in life. Nevertheless, some individuals who have experienced childhood maltreatment...

    Authors: Konstantinos Ioannidis, Adrian Dahl Askelund, Rogier A. Kievit and Anne-Laura van Harmelen

    Citation: BMC Medicine 2020 18:32

    Content type: Opinion

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    The Correction to this article has been published in BMC Medicine 2020 18:202

  8. Undiagnosed tuberculosis (TB) remains the most common cause of HIV-related mortality. Xpert MTB/RIF (Xpert) is being rolled out globally to improve TB diagnostic capacity. However, previous Xpert impact trials...

    Authors: Andrew F. Auld, Tefera Agizew, Anikie Mathoma, Rosanna Boyd, Anand Date, Sherri L. Pals, Christopher Serumola, Unami Mathebula, Heather Alexander, Tedd V. Ellerbrock, Goabaone Rankgoane-Pono, Pontsho Pono, James C. Shepherd, Katherine Fielding, Alison D. Grant and Alyssa Finlay

    Citation: BMC Medicine 2020 18:19

    Content type: Research article

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  9. Many malaria-endemic areas experience seasonal fluctuations in case incidence as Anopheles mosquito and Plasmodium parasite life cycles respond to changing environmental conditions. Identifying location-specific ...

    Authors: Michele Nguyen, Rosalind E. Howes, Tim C.D. Lucas, Katherine E. Battle, Ewan Cameron, Harry S. Gibson, Jennifer Rozier, Suzanne Keddie, Emma Collins, Rohan Arambepola, Su Yun Kang, Chantal Hendriks, Anita Nandi, Susan F. Rumisha, Samir Bhatt, Sedera A. Mioramalala…

    Citation: BMC Medicine 2020 18:26

    Content type: Research Article

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  10. The human brain is complex and interconnected structurally. Brain connectome change is associated with Alzheimer’s disease (AD) and other neurodegenerative diseases. Genetics and genomics studies have identifi...

    Authors: Young Jae Woo, Panos Roussos, Vahram Haroutunian, Pavel Katsel, Samuel Gandy, Eric E. Schadt and Jun Zhu

    Citation: BMC Medicine 2020 18:23

    Content type: Research article

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  11. Varenicline, bupropion and nicotine replacement therapy (NRT) are three effective pharmacotherapies for smoking cessation, but data about their safety in pregnancy are limited. We assessed the risk of adverse ...

    Authors: Duong Thuy Tran, David B. Preen, Kristjana Einarsdottir, Anna Kemp-Casey, Deborah Randall, Louisa R. Jorm, Stephanie K. Y. Choi and Alys Havard

    Citation: BMC Medicine 2020 18:15

    Content type: Research article

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  12. Following publication of the original article [1], the authors reported that there was an error in Figure 9, which contained a misplaced picture. The authors confirm that all of the published results and concl...

    Authors: Gang Chen, Peter Kronenberger, Erik Teugels, Ijeoma Adaku Umelo and Jacques De Grève

    Citation: BMC Medicine 2020 18:29

    Content type: Correction

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    The original article was published in BMC Medicine 2012 10:28

  13. There has been a successful push towards parasitological diagnosis of malaria in Africa, mainly with rapid diagnostic tests (mRDTs), which has reduced over-prescribing of artemisinin-based combination therapie...

    Authors: Shennae O’Boyle, Katia J. Bruxvoort, Evelyn K. Ansah, Helen E. D. Burchett, Clare I. R. Chandler, Siân E. Clarke, Catherine Goodman, Wilfred Mbacham, Anthony K. Mbonye, Obinna E. Onwujekwe, Sarah G. Staedke, Virginia L. Wiseman, Christopher J. M. Whitty and Heidi Hopkins

    Citation: BMC Medicine 2020 18:17

    Content type: Research article

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  14. In order to improve malaria burden estimates in low transmission settings, more sensitive tools and efficient sampling strategies are required. This study evaluated the use of serological measures from repeate...

    Authors: Henry Surendra, Supargiyono, Riris A. Ahmad, Rizqiani A. Kusumasari, Theodola B. Rahayujati, Siska Y. Damayanti, Kevin K. A. Tetteh, Chetan Chitnis, Gillian Stresman, Jackie Cook and Chris Drakeley

    Citation: BMC Medicine 2020 18:9

    Content type: Research article

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  15. An update of the chapter on Mental, Behavioral and Neurodevelopmental Disorders in the International Classification of Diseases and Related Health Problems (ICD) is of great interest around the world. The rece...

    Authors: Dan J. Stein, Peter Szatmari, Wolfgang Gaebel, Michael Berk, Eduard Vieta, Mario Maj, Ymkje Anna de Vries, Annelieke M. Roest, Peter de Jonge, Andreas Maercker, Chris R. Brewin, Kathleen M. Pike, Carlos M. Grilo, Naomi A. Fineberg, Peer Briken, Peggy T. Cohen-Kettenis…

    Citation: BMC Medicine 2020 18:21

    Content type: Forum

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    The Commentary to this article has been published in BMC Medicine 2020 18:25

  16. The original article [1] contains an omitted grant acknowledgement and affiliation as relates to the contribution of co-author, Rafael Perera-Salazar. As such, the following two amendments should apply to the ...

    Authors: Magdalena Nowakowska, Salwa S. Zghebi, Darren M. Ashcroft, Iain Buchan, Carolyn Chew-Graham, Tim Holt, Christian Mallen, Harm Van Marwijk, Niels Peek, Rafael Perera-Salazar, David Reeves, Martin K. Rutter, Stephen F. Weng, Nadeem Qureshi, Mamas A. Mamas and Evangelos Kontopantelis

    Citation: BMC Medicine 2020 18:22

    Content type: Correction

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    The original article was published in BMC Medicine 2019 17:145

  17. Dystroglycanopathies are a group of inherited disorders characterized by vast clinical and genetic heterogeneity and caused by abnormal functioning of the ECM receptor dystroglycan (Dg). Remarkably, among many...

    Authors: Andriy S. Yatsenko, Mariya M. Kucherenko, Yuanbin Xie, Dina Aweida, Henning Urlaub, Renate J. Scheibe, Shenhav Cohen and Halyna R. Shcherbata

    Citation: BMC Medicine 2020 18:8

    Content type: Research article

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  18. Participation in randomized controlled trials (RCTs) may be quite demanding and could represent an important burden for patients. We aimed to explore this research burden (i.e., the psychological, physical, an...

    Authors: Nivantha Naidoo, Van Thu Nguyen, Philippe Ravaud, Bridget Young, Philippe Amiel, Daniel Schanté, Mike Clarke and Isabelle Boutron

    Citation: BMC Medicine 2020 18:6

    Content type: Research article

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  19. Inflammation contributes to the pathophysiology of major depressive disorder (MDD), and anti-inflammatory strategies might therefore have therapeutic potential. This trial aimed to determine whether adjunctive...

    Authors: Michael Berk, Mohammadreza Mohebbi, Olivia M. Dean, Sue M. Cotton, Andrew M. Chanen, Seetal Dodd, Aswin Ratheesh, G. Paul Amminger, Mark Phelan, Amber Weller, Andrew Mackinnon, Francesco Giorlando, Shelley Baird, Lisa Incerti, Rachel E. Brodie, Natalie O. Ferguson…

    Citation: BMC Medicine 2020 18:16

    Content type: Research article

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  20. In endemic areas, pregnant women are highly susceptible to Plasmodium falciparum malaria characterized by the accumulation of parasitized red blood cells (pRBC) in the placenta. In subsequent pregnancies, women d...

    Authors: Julia C. Cutts, Paul A. Agius, Zaw Lin, Rosanna Powell, Kerryn Moore, Bridget Draper, Julie A. Simpson and Freya J. I. Fowkes

    Citation: BMC Medicine 2020 18:14

    Content type: Research article

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  21. The present study aims to assess the cost-effectiveness of an influenza vaccination program for children in the Netherlands. This requires an evaluation of the long-term impact of such a program on the burden ...

    Authors: Pieter T. de Boer, Jantien A. Backer, Albert Jan van Hoek and Jacco Wallinga

    Citation: BMC Medicine 2020 18:11

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2020 18:37

  22. The consumption of free sugars in the UK is more than double the guideline intake for adults and close to triple for children, with soft drinks representing a significant proportion. The aim of this study was ...

    Authors: L. K. Bandy, P. Scarborough, R. A. Harrington, M. Rayner and S. A. Jebb

    Citation: BMC Medicine 2020 18:20

    Content type: Research article

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  23. Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a subsequent NCD, defined as multimorbidity, has been scarcely inv...

    Authors: Heinz Freisling, Vivian Viallon, Hannah Lennon, Vincenzo Bagnardi, Cristian Ricci, Adam S. Butterworth, Michael Sweeting, David Muller, Isabelle Romieu, Pauline Bazelle, Marina Kvaskoff, Patrick Arveux, Gianluca Severi, Christina Bamia, Tilman Kühn, Rudolf Kaaks…

    Citation: BMC Medicine 2020 18:5

    Content type: Research article

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  24. Promoting breastfeeding is an important public health intervention, with benefits for infants and mothers. Even modest increases in prevalence and duration may yield considerable economic savings. However, des...

    Authors: Mary S. Fewtrell, Nurul H. Mohd Shukri and Jonathan C. K. Wells

    Citation: BMC Medicine 2020 18:4

    Content type: Opinion

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  25. Endometriosis is a gynaecological condition characterised by immune cell infiltration and distinct inflammatory signatures found in the peritoneal cavity. In this study, we aim to characterise the immune micro...

    Authors: Manman Guo, Cemsel Bafligil, Thomas Tapmeier, Carol Hubbard, Sanjiv Manek, Catherine Shang, Fernando O. Martinez, Nicole Schmidt, Maik Obendorf, Holger Hess-Stumpp, Thomas M. Zollner, Stephen Kennedy, Christian M. Becker, Krina T. Zondervan, Adam P. Cribbs and Udo Oppermann

    Citation: BMC Medicine 2020 18:3

    Content type: Research article

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  26. Heart failure (HF) has been recognized as a global pandemic with a high rate of hospitalization, morbidity, and mortality. Although numerous advances have been made, its representative molecular signatures rem...

    Authors: Xiumeng Hua, Yin-Ying Wang, Peilin Jia, Qing Xiong, Yiqing Hu, Yuan Chang, Songqing Lai, Yong Xu, Zhongming Zhao and Jiangping Song

    Citation: BMC Medicine 2020 18:2

    Content type: Research article

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  27. Antimicrobial resistance (AMR) is an increasing threat to global health. There are > 14 million cases of enteric fever every year and > 135,000 deaths. The disease is primarily controlled by antimicrobial trea...

    Authors: Annie J. Browne, Bahar H. Kashef Hamadani, Emmanuelle A. P. Kumaran, Puja Rao, Joshua Longbottom, Eli Harriss, Catrin E. Moore, Susanna Dunachie, Buddha Basnyat, Stephen Baker, Alan D. Lopez, Nicholas P. J. Day, Simon I. Hay and Christiane Dolecek

    Citation: BMC Medicine 2020 18:1

    Content type: Research article

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  28. Evaluation of health technology programmes should be theoretically informed, interdisciplinary, and generate in-depth explanations. The NASSS (non-adoption, abandonment, scale-up, spread, sustainability) frame...

    Authors: Seye Abimbola, Bindu Patel, David Peiris, Anushka Patel, Mark Harris, Tim Usherwood and Trisha Greenhalgh

    Citation: BMC Medicine 2019 17:233

    Content type: Research article

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  29. Repeated outbreaks of emerging pathogens underscore the need for preparedness plans to prevent, detect, and respond. As countries develop and improve National Action Plans for Health Security, addressing subna...

    Authors: E. N. Hulland, K. E. Wiens, S. Shirude, J. D. Morgan, A. Bertozzi-Villa, T. H. Farag, N. Fullman, M. U. G. Kraemer, M. K. Miller-Petrie, V. Gupta, R. C. Reiner Jr., P. Rabinowitz, J. N. Wasserheit, B. P. Bell, S. I. Hay, D. J. Weiss…

    Citation: BMC Medicine 2019 17:232

    Content type: Research article

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  30. There are an estimated 800,000 suicides per year globally, and approximately 16,000,000 suicide attempts. Mobile apps may help address the unmet needs of people at risk. We assessed adherence of suicide preven...

    Authors: Laura Martinengo, Louise Van Galen, Elaine Lum, Martin Kowalski, Mythily Subramaniam and Josip Car

    Citation: BMC Medicine 2019 17:231

    Content type: Research article

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  31. The assessment of calibration performance of risk prediction models based on regression or more flexible machine learning algorithms receives little attention.

    Authors: Ben Van Calster, David J. McLernon, Maarten van Smeden, Laure Wynants and Ewout W. Steyerberg

    Citation: BMC Medicine 2019 17:230

    Content type: Opinion

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  32. Delirium is a common severe neuropsychiatric condition secondary to physical illness, which predominantly affects older adults in hospital. Prior to this study, the UK point prevalence of delirium was unknown....

    Authors:

    Citation: BMC Medicine 2019 17:229

    Content type: Research article

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  33. In January 2017, the Dutch cervical cancer screening programme transitioned from cytomorphological to primary high-risk HPV (hrHPV) DNA screening, including the introduction of self-sampling, for women aged be...

    Authors: Clare A. Aitken, Heleen M. E. van Agt, Albert G. Siebers, Folkert J. van Kemenade, Hubert G. M. Niesters, Willem J. G. Melchers, Judith E. M. Vedder, Rob Schuurman, Adriaan J. C. van den Brule, Hans C. van der Linden, John W. J. Hinrichs, Anco Molijn, Klaas J. Hoogduin, Bettien M. van Hemel and Inge M. C. M. de Kok

    Citation: BMC Medicine 2019 17:228

    Content type: Research article

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  34. Proprotein convertase subtilisin/kexin 9 (PCSK9) is an important regulator of low-density lipoprotein receptor (LDLR) and plasma levels of LDL cholesterol (LDL-C). PCSK9 inhibition is an efficient therapeutic ...

    Authors: Amir Abbas Momtazi-Borojeni, Mahmoud Reza Jaafari, Ali Badiee, Maciej Banach and Amirhossein Sahebkar

    Citation: BMC Medicine 2019 17:223

    Content type: Research article

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  35. As malaria transmission declines, understanding the differential impact of intensified control on Plasmodium falciparum relative to Plasmodium vivax and identifying key drivers of ongoing transmission is essentia...

    Authors: Maria Ome-Kaius, Johanna Helena Kattenberg, Sophie Zaloumis, Matthew Siba, Benson Kiniboro, Shadrach Jally, Zahra Razook, Daisy Mantila, Desmond Sui, Jason Ginny, Anna Rosanas-Urgell, Stephan Karl, Thomas Obadia, Alyssa Barry, Stephen J. Rogerson, Moses Laman…

    Citation: BMC Medicine 2019 17:220

    Content type: Research article

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  36. Variable and poor care quality are important causes of preventable patient harm. Many patients receive less than recommended care, but the extent of the problem remains largely unknown. The CareTrack Kids (CTK...

    Authors: Louise K. Wiles, Carl de Wet, Chris Dalton, Elisabeth Murphy, Mark F. Harris, Peter D. Hibbert, Charlotte J. Molloy, Gaston Arnolda, Hsuen P. Ting and Jeffrey Braithwaite

    Citation: BMC Medicine 2019 17:218

    Content type: Research article

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  37. In November 2011, Malawi introduced the 13-valent pneumococcal conjugate vaccine (PCV13) into the routine infant schedule. Four to 7 years after introduction (2015–2018), rolling prospective nasopharyngeal car...

    Authors: J. Lourenço, U. Obolski, T. D. Swarthout, A. Gori, N. Bar-Zeev, D. Everett, A. W. Kamng’ona, T. S. Mwalukomo, A. A. Mataya, C. Mwansambo, M. Banda, S. Gupta, N. French and R. S. Heyderman

    Citation: BMC Medicine 2019 17:219

    Content type: Research article

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  38. The nature of symptoms in the prodromal period of first episode psychosis (FEP) remains unclear. The objective was to determine the patterns of symptoms recorded in primary care in the 5 years before FEP diagn...

    Authors: Ying Chen, Saeed Farooq, John Edwards, Carolyn A. Chew-Graham, David Shiers, Martin Frisher, Richard Hayward, Athula Sumathipala and Kelvin P. Jordan

    Citation: BMC Medicine 2019 17:227

    Content type: Research article

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  39. Associations between type 2 diabetes (T2D) and amyotrophic lateral sclerosis (ALS) were discovered in observational studies in both European and East Asian populations. However, whether such associations are c...

    Authors: Ping Zeng, Ting Wang, Junnian Zheng and Xiang Zhou

    Citation: BMC Medicine 2019 17:225

    Content type: Research article

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  40. Even though in situ breast cancer (BCIS) accounts for a large proportion of the breast cancers diagnosed, few studies have investigated potential risk factors for BCIS. Their results suggest that some establis...

    Authors: Nena Karavasiloglou, Anika Hüsing, Giovanna Masala, Carla H. van Gils, Renée Turzanski Fortner, Jenny Chang-Claude, Inge Huybrechts, Elisabete Weiderpass, Marc Gunter, Patrick Arveux, Agnès Fournier, Marina Kvaskoff, Anne Tjønneland, Cecilie Kyrø, Christina C. Dahm, Helene Tilma Vistisen…

    Citation: BMC Medicine 2019 17:221

    Content type: Research article

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  41. Insulin resistance (IR) is predictive for type 2 diabetes and associated with various metabolic abnormalities in fasting conditions. However, limited data are available on how IR affects metabolic responses in...

    Authors: Qin Wang, Jari Jokelainen, Juha Auvinen, Katri Puukka, Sirkka Keinänen-Kiukaanniemi, Marjo-Riitta Järvelin, Johannes Kettunen, Ville-Petteri Mäkinen and Mika Ala-Korpela

    Citation: BMC Medicine 2019 17:217

    Content type: Research article

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