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  1. Both changes in circulating lipids represented by a validated poor prognostic 3-lipid signature (3LS) and somatic tumour genetic aberrations are individually associated with worse clinical outcomes in men with...

    Authors: Blossom Mak, Hui-Ming Lin, Edmond M. Kwan, Heidi Fettke, Ben Tran, Ian D. Davis, Kate Mahon, Martin R. Stockler, Karen Briscoe, Gavin Marx, Alison Zhang, Megan Crumbaker, Winston Tan, Kevin Huynh, Thomas G. Meikle, Natalie A. Mellett…
    Citation: BMC Medicine 2022 20:112
  2. Women’s reproductive factors include their age at menarche and menopause, the age at which they start and stop having children and the number of children they have. Studies that have linked these factors with ...

    Authors: Claire Prince, Gemma C. Sharp, Laura D. Howe, Abigail Fraser and Rebecca C. Richmond
    Citation: BMC Medicine 2022 20:103
  3. High variability in the definition and interpretation of organized cancer screening needs to be addressed systematically. Moreover, the relevance of the current practice of categorizing screening programmes di...

    Authors: Li Zhang, André L. Carvalho, Isabel Mosquera, Tianmeng Wen, Eric Lucas, Catherine Sauvaget, Richard Muwonge, Marc Arbyn, Elisabete Weiderpass and Partha Basu
    Citation: BMC Medicine 2022 20:101
  4. The effect of ezetimibe, Niemann-Pick C1-like 1 inhibitor, on liver fat is not clearly elucidated. Our primary objective was to evaluate the efficacy of ezetimibe plus rosuvastatin versus rosuvastatin monother...

    Authors: Yongin Cho, Hyungjin Rhee, Young-eun Kim, Minyoung Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Jin-Young Choi and Yong-ho Lee
    Citation: BMC Medicine 2022 20:93
  5. Eliminating Plasmodium vivax will require targeting the hidden liver-stage reservoir of hypnozoites. This necessitates new interventions balancing the benefit of reducing vivax transmission against the risk of ov...

    Authors: Thomas Obadia, Narimane Nekkab, Leanne J. Robinson, Chris Drakeley, Ivo Mueller and Michael T. White
    Citation: BMC Medicine 2022 20:98
  6. Safety after the second dose of the SARS-CoV-2 vaccine remains to be elucidated, especially among individuals reporting adverse events after their first dose. This study aims to evaluate the impact of a delaye...

    Authors: Carlos King Ho Wong, Xi Xiong, Kristy Tsz Kwan Lau, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Xue Li, Esther Wai Yin Chan, Eric Yuk Fai Wan, Ivan Chi Ho Au, Benjamin John Cowling, Cheuk Kwong Lee and Ian Chi Kei Wong
    Citation: BMC Medicine 2022 20:119
  7. HER2-low breast cancer (BC) is currently an area of active interest. This study evaluated the impact of low expression of HER2 on survival outcomes in HER2-negative non-metastatic breast cancer (BC).

    Authors: Ryan Shea Ying Cong Tan, Whee Sze Ong, Kyung-Hun Lee, Abner Herbert Lim, Seri Park, Yeon Hee Park, Ching-Hung Lin, Yen-Shen Lu, Makiko Ono, Takayuki Ueno, Yoichi Naito, Tatsuya Onishi, Geok-Hoon Lim, Su-Ming Tan, Han-Byoel Lee, Han Suk Ryu…
    Citation: BMC Medicine 2022 20:105
  8. Faecal immunochemical tests (FITs) are used to triage primary care patients with symptoms that could be caused by colorectal cancer for referral to colonoscopy. The aim of this study was to determine whether c...

    Authors: Diana R. Withrow, Brian Shine, Jason Oke, Andres Tamm, Tim James, Eva Morris, Jim Davies, Steve Harris, James E. East and Brian D. Nicholson
    Citation: BMC Medicine 2022 20:116
  9. Fall risk screening using multiple methods was strongly advised as the initial step for preventing fall. Currently, there is only one such tool which was proposed by the U.S. Centers for Disease Control and Pr...

    Authors: Sriprapa Loonlawong, Weerawat Limroongreungrat, Thanapoom Rattananupong, Kamonrat Kittipimpanon, Wanvisa Saisanan Na Ayudhaya and Wiroj Jiamjarasrangsi
    Citation: BMC Medicine 2022 20:78
  10. Targeted therapy is the key for improving overall survival while decreasing the undesirable adverse effects of cancer treatment. Patients who received matched targeted therapies showed dramatically improved ov...

    Authors: Zhijun Zhou and Min Li
    Citation: BMC Medicine 2022 20:90
  11. Subnational heterogeneity in immunity to measles can create pockets of susceptibility and result in long-lasting outbreaks despite high levels of national vaccine coverage. The elimination status defined by th...

    Authors: Alexis Robert, Adam J. Kucharski and Sebastian Funk
    Citation: BMC Medicine 2022 20:77
  12. Dynamic modeling is commonly used to evaluate direct and indirect effects of interventions on infectious disease incidence. The risk of secondary outcomes (e.g., death) attributable to infection may depend on ...

    Authors: Allison Portnoy, Yuli Lily Hsieh, Kaja Abbas, Petra Klepac, Heather Santos, Logan Brenzel, Mark Jit and Matthew Ferrari
    Citation: BMC Medicine 2022 20:113
  13. Plasmodium vivax (P. vivax) is the dominant Plasmodium spp. causing the disease malaria in low-transmission regions outside of Africa. These regions often feature high proportions of asymptomatic patients with su...

    Authors: Zoe Shih-Jung Liu, Jetsumon Sattabongkot, Michael White, Sadudee Chotirat, Chalermpon Kumpitak, Eizo Takashima, Matthias Harbers, Wai-Hong Tham, Julie Healer, Chetan E. Chitnis, Takafumi Tsuboi, Ivo Mueller and Rhea J. Longley
    Citation: BMC Medicine 2022 20:89
  14. Differences in definitions and methodological approaches have hindered comparison and synthesis of economic evaluation results across multiple health domains, including immunization. At the request of the Worl...

    Authors: Ann Levin, Laura Boonstoppel, Logan Brenzel, Ulla Griffiths, Raymond Hutubessy, Mark Jit, Vittal Mogasale, Sarah Pallas, Stephen Resch, Christian Suharlim and Karene Hoi Ting Yeung
    Citation: BMC Medicine 2022 20:88
  15. Antagonizing the androgen-receptor (AR) pathway is an effective treatment strategy for patients with metastatic castration-resistant prostate cancer (CRPC). Here, we report the results of a first-in-human phas...

    Authors: Xiaojian Qin, Dongmei Ji, Weijie Gu, Weiqing Han, Hong Luo, Chuanjun Du, Qing Zou, Zhongquan Sun, Chaohong He, Shaoxing Zhu, Tie Chong, Xin Yao, Ben Wan, Xinfeng Yang, Aobing Bai, Chunlei Jin…
    Citation: BMC Medicine 2022 20:84
  16. The COVID-19 pandemic is caused by the betacoronavirus SARS-CoV-2. In November 2021, the Omicron variant was discovered and immediately classified as a variant of concern (VOC), since it shows substantially mo...

    Authors: Maren Schubert, Federico Bertoglio, Stephan Steinke, Philip Alexander Heine, Mario Alberto Ynga-Durand, Henrike Maass, Josè Camilla Sammartino, Irene Cassaniti, Fanglei Zuo, Likun Du, Janin Korn, Marko Milošević, Esther Veronika Wenzel, Fran Krstanović, Saskia Polten, Marina Pribanić-Matešić…
    Citation: BMC Medicine 2022 20:102
  17. The shortage of available organs for life-saving transplants persists worldwide. While a majority support donating their organs or tissue when they die, many have not registered their wish to do so. When regis...

    Authors: Alvin Ho-ting Li, Amit X. Garg, Jeremy M. Grimshaw, Versha Prakash, Alexie J. Dunnett, Stephanie N. Dixon, Monica Taljaard, Joanna Mitchell, Kyla L. Naylor, Cathy Faulds, Rachel Bevan, Leah Getchell, Greg Knoll, S. Joseph Kim, Jessica Sontrop, Allison Tong…
    Citation: BMC Medicine 2022 20:75
  18. Studies have suggested incremental short-term adverse events (AE) after repeated vaccination. In this report, we assessed occurrence and risk factors for short-term AEs following repeated SARS-CoV-2 vaccinatio...

    Authors: Luuk Wieske, Laura Y. L. Kummer, Koos P. J. van Dam, Eileen W. Stalman, Anneke J. van der Kooi, Joost Raaphorst, Mark Löwenberg, R. Bart Takkenberg, Adriaan G. Volkers, Geert R. A. M. D’Haens, Sander W. Tas, Phyllis I. Spuls, Marcel W. Bekkenk, Annelie H. Musters, Nicoline F. Post, Angela L. Bosma…
    Citation: BMC Medicine 2022 20:100
  19. Accurate and non-invasive diagnosis of pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP) can avoid unnecessary puncture and surgery. This study aimed to develop a deep learning radiomics (D...

    Authors: Tong Tong, Jionghui Gu, Dong Xu, Ling Song, Qiyu Zhao, Fang Cheng, Zhiqiang Yuan, Shuyuan Tian, Xin Yang, Jie Tian, Kun Wang and Tian’an Jiang
    Citation: BMC Medicine 2022 20:74
  20. Authors: Chathika K. Weerasuriya, Rebecca C. Harris, C. Finn McQuaid, Fiammetta Bozzani, Yunzhou Ruan, Renzhong Li, Tao Li, Kirankumar Rade, Raghuram Rao, Ann M. Ginsberg, Gabriela B. Gomez and Richard G. White
    Citation: BMC Medicine 2022 20:99

    The original article was published in BMC Medicine 2021 19:60

  21. Type 2 diabetes is one of the leading causes of chronic kidney failure, which increases globally and represents a significant threat to public health. People from the Middle East represent one of the largest i...

    Authors: Siham A. Mohamed, Juan Fernadez-Tajes, Paul W. Franks and Louise Bennet
    Citation: BMC Medicine 2022 20:76
  22. The combined health impact of physical activity (PA) and air pollution on chronic obstructive pulmonary disease (COPD) remains unclear. We investigated the joint effects of habitual PA and long-term fine parti...

    Authors: Lan Chen, Miao Cai, Haitao Li, Xiaojie Wang, Fei Tian, Yinglin Wu, Zilong Zhang and Hualiang Lin
    Citation: BMC Medicine 2022 20:70
  23. The success of antithrombotic therapies is assessed based on thrombotic and bleeding events. Simultaneously assessing both kinds of events might be challenging, and recurrent bleeding events are often ignored....

    Authors: Kunihiko Matsui, Satoshi Yasuda, Koichi Kaikita, Masaharu Akao, Junya Ako, Tetsuya Matoba, Masato Nakamura, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama and Hisao Ogawa
    Citation: BMC Medicine 2022 20:69
  24. Rapid antigen diagnostic tests (Ag-RDTs) are the most widely used point-of-care tests for detecting SARS-CoV-2 infection. Since the accuracy may have altered by changes in SARS-CoV-2 epidemiology, indications ...

    Authors: Roderick P. Venekamp, Irene K. Veldhuijzen, Karel G. M. Moons, Wouter van den Bijllaardt, Suzan D. Pas, Esther B. Lodder, Richard Molenkamp, Zsofi Igloi, Constantijn Wijers, Claudy Oliveira dos Santos, Sylvia B. Debast, Marjan J. Bruins, Khaled Polad, Carla R. S. Nagel-Imming, Wanda G. H. Han, Janneke H. H. M. van de Wijgert…
    Citation: BMC Medicine 2022 20:97
  25. The associations of cancer with types of diets, including vegetarian, fish, and poultry-containing diets, remain unclear. The aim of this study was, therefore, to investigate the association of type of diet wi...

    Authors: Solange Parra-Soto, Danay Ahumada, Fanny Petermann-Rocha, Jirapitcha Boonpoor, Jose Lara Gallegos, Jana Anderson, Linda Sharp, Fiona C. Malcomson, Katherine M. Livingstone, John C. Mathers, Jill P. Pell, Frederick K. Ho and Carlos Celis-Morales
    Citation: BMC Medicine 2022 20:79

    The Commentary to this article has been published in BMC Medicine 2022 20:81

    The Research article to this article has been published in BMC Medicine 2022 20:73

  26. Following a vegetarian diet has become increasingly popular and some evidence suggests that being vegetarian may be associated with a lower risk of cancer overall. However, for specific cancer sites, the evide...

    Authors: Cody Z. Watling, Julie A. Schmidt, Yashvee Dunneram, Tammy Y. N. Tong, Rebecca K. Kelly, Anika Knuppel, Ruth C. Travis, Timothy J. Key and Aurora Perez-Cornago
    Citation: BMC Medicine 2022 20:73

    The Commentary to this article has been published in BMC Medicine 2022 20:81

    The Research article to this article has been published in BMC Medicine 2022 20:79

  27. The active surveillance of students is proposed as an effective strategy to contain SARS-CoV-2 spread and prevent schools’ closure. Saliva for molecular testing is as sensitive as naso-pharyngeal swab (NPS), s...

    Authors: Daniela Basso, Ada Aita, Filippo Navaglia, Paola Mason, Stefania Moz, Alessio Pinato, Barbara Melloni, Luca Iannelli, Andrea Padoan, Chiara Cosma, Angelo Moretto, Alberto Scuttari, Daniela Mapelli, Rosario Rizzuto and Mario Plebani
    Citation: BMC Medicine 2022 20:96
  28. Long-term-specific sequelae or persistent symptoms (SPS) after hospitalisation due to COVID-19 are not known. The aim of this study was to explore the presence of SPS 12 months after discharge in survivors hos...

    Authors: Mario Rivera-Izquierdo, Antonio Jesús Láinez-Ramos-Bossini, Inmaculada Guerrero-Fernández de Alba, Rocío Ortiz-González-Serna, Álvaro Serrano-Ortiz, Nicolás Francisco Fernández-Martínez, Rafael Ruiz-Montero and Jorge A. Cervilla
    Citation: BMC Medicine 2022 20:92
  29. Attention deficit hyperactivity disorder (ADHD) is a highly heritable, neurodevelopmental disorder known to associate with more than double the risk of death compared with people without ADHD. Because most res...

    Authors: Olesya Ajnakina, Diana Shamsutdinova, Theresa Wimberley, Søren Dalsgaard and Andrew Steptoe
    Citation: BMC Medicine 2022 20:62
  30. Prospective population-based studies investigating multiple determinants of pre-vaccination antibody responses to SARS-CoV-2 are lacking.

    Authors: Mohammad Talaei, Sian Faustini, Hayley Holt, David A. Jolliffe, Giulia Vivaldi, Matthew Greenig, Natalia Perdek, Sheena Maltby, Carola M. Bigogno, Jane Symons, Gwyneth A. Davies, Ronan A. Lyons, Christopher J. Griffiths, Frank Kee, Aziz Sheikh, Alex G. Richter…
    Citation: BMC Medicine 2022 20:87
  31. Excisional treatment of cervical intraepithelial neoplasia (CIN) has been associated with increased risk of preterm delivery (PTD), although the underlying mechanism is as yet unclear. Studies on formalin-fixe...

    Authors: Johanna Wiik, Cecilia Kärrberg, Staffan Nilsson, Björn Strander, Bo Jacobsson and Verena Sengpiel
    Citation: BMC Medicine 2022 20:61
  32. HRV has mostly shown associations with systolic dysfunction and more recently, with diastolic dysfunction in Heart failure (HF) patients. But the role of sympathetic nervous system in changes of left ventricul...

    Authors: Banafsheh Arshi, Sven Geurts, Martijn J. Tilly, Marten van den Berg, Jan A. Kors, Dimitris Rizopoulos, M. Arfan Ikram and Maryam Kavousi
    Citation: BMC Medicine 2022 20:91
  33. Forecasting healthcare demand is essential in epidemic settings, both to inform situational awareness and facilitate resource planning. Ideally, forecasts should be robust across time and locations. During the...

    Authors: Sophie Meakin, Sam Abbott, Nikos Bosse, James Munday, Hugo Gruson, Joel Hellewell, Katharine Sherratt and Sebastian Funk
    Citation: BMC Medicine 2022 20:86
  34. Childhood abuse and neglect have been associated with premenstrual disorders (PMDs), including premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD). However, the associations of other adverse...

    Authors: Qian Yang, Edda Björk Þórðardóttir, Arna Hauksdóttir, Thor Aspelund, Jóhanna Jakobsdóttir, Thorhildur Halldorsdottir, Gunnar Tomasson, Harpa Rúnarsdóttir, Hilda Björk Danielsdottir, Elizabeth R. Bertone-Johnson, Arvid Sjölander, Fang Fang, Donghao Lu and Unnur Anna Valdimarsdóttir
    Citation: BMC Medicine 2022 20:60
  35. Vitamin D status has been implicated in COVID-19 disease. The objective of the COVID-VIT-D trial was to investigate if an oral bolus of cholecalciferol (100,000 IU) administered at hospital admission influence...

    Authors: Jorge B. Cannata-Andía, Augusto Díaz-Sottolano, Pehuén Fernández, Carmen Palomo-Antequera, Pablo Herrero-Puente, Ricardo Mouzo, Natalia Carrillo-López, Sara Panizo, Guillermo H. Ibañez, Carlos A. Cusumano, Carolina Ballarino, Vicente Sánchez-Polo, Jacqueline Pefaur-Penna, Irene Maderuelo-Riesco, Jesús Calviño-Varela, Mónica D. Gómez…
    Citation: BMC Medicine 2022 20:83
  36. In countries with high COVID-19 vaccination rates the SARS-CoV-2 Delta variant resulted in rapidly increasing case numbers. This study evaluated the use of non-pharmaceutical interventions (NPIs) coupled with ...

    Authors: George J. Milne, Julian Carrivick and David Whyatt
    Citation: BMC Medicine 2022 20:80
  37. Patients with disorders of gut-brain interaction (DGBI) report meal intake to be associated with symptoms. DGBI patients with meal-related symptoms may have more severe symptoms overall and worse health outcom...

    Authors: Esther Colomier, Chloé Melchior, Joost P. Algera, Jóhann P. Hreinsson, Stine Störsrud, Hans Törnblom, Lukas Van Oudenhove, Olafur S. Palsson, Shrikant I. Bangdiwala, Ami D. Sperber, Jan Tack and Magnus Simrén
    Citation: BMC Medicine 2022 20:71
  38. Genome-wide association studies (GWASs) have identified multiple risk loci for Parkinson’s disease (PD). However, identifying the functional (or potential causal) variants in the reported risk loci and elucida...

    Authors: Rui Chen, Jiewei Liu, Shiwu Li, Xiaoyan Li, Yongxia Huo, Yong-Gang Yao, Xiao Xiao, Ming Li and Xiong-Jian Luo
    Citation: BMC Medicine 2022 20:68
  39. Contested evidence suggests that obesity confers no risk to health in people who have a healthy lifestyle, particularly if there are no metabolic complications of obesity. The aim was to examine the associatio...

    Authors: Laura Heath, Susan A. Jebb, Paul Aveyard and Carmen Piernas
    Citation: BMC Medicine 2022 20:65
  40. Breast cancer is the most commonly diagnosed cancer worldwide and is one of the leading causes of cancer death. The incidence, pathological features, and clinical outcomes in breast cancer differ by geographic...

    Authors: Kelly A. Hirko, Gabrielle Rocque, Erica Reasor, Ammanuel Taye, Alex Daly, Ramsey I. Cutress, Ellen R. Copson, Dae-Won Lee, Kyung-Hun Lee, Seock-Ah Im and Yeon Hee Park
    Citation: BMC Medicine 2022 20:72
  41. The comorbidity between polycystic ovary syndrome (PCOS) and obesity has long been observed in clinical settings, but their shared genetic basis remains unclear.

    Authors: Qianwen Liu, Zhaozhong Zhu, Peter Kraft, Qiaolin Deng, Elisabet Stener-Victorin and Xia Jiang
    Citation: BMC Medicine 2022 20:66
  42. Bevacizumab improves survival outcomes in women diagnosed with epithelial ovarian cancer (EOC). Pre-clinical data showed that the c-MET/VEGFR-2 heterocomplex negates VEGF inhibition through activation of c-MET...

    Authors: Robert D. Morgan, Cristina Ferreras, Isabel Peset, Egle Avizienyte, Andrew G. Renehan, Richard J. Edmondson, Alexander D. Murphy, Shibani Nicum, Thomas Van Brussel, Andrew R. Clamp, Diether Lambrechts, Cong Zhou and Gordon C. Jayson
    Citation: BMC Medicine 2022 20:59
  43. China experiences large variations in influenza seasonal activity. We aim to update and improve the current understanding of regional-based within-year variations of influenza activity across mainland China to...

    Authors: Charlie Diamond, Hui Gong, Fiona Yueqian Sun, Yang Liu, Billy J. Quilty, Mark Jit, Juan Yang, Hongjie Yu, W. John Edmunds and Marc Baguelin
    Citation: BMC Medicine 2022 20:58
  44. The World Health Organization’s (WHO) 25X25 goal aims for a 25% relative reduction in premature death due to four non-communicable diseases (NCD4)—cancer, cardiovascular disease, chronic respiratory diseases a...

    Authors: Alison Wijnen, Karen Bishop, Grace Joshy, Yuehan Zhang, Emily Banks and Ellie Paige
    Citation: BMC Medicine 2022 20:57