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  1. The coronavirus disease (COVID-19) pandemic may have had significant mental health consequences for military personnel, which is a population already exposed to psychological stress. To assess the potential im...

    Authors: Marc-Antoine Sanchez, Basile Fuchs, Pascale Tubert-Bitter, Anne-Sophie Mariet, Fabrice Jollant, Aurélie Mayet and Catherine Quantin
    Citation: BMC Medicine 2022 20:306
  2. Zika virus (ZIKV), first discovered in Uganda in 1947, re-emerged globally in 2013 and was later associated with microcephaly and other birth defects. We determined the incidence of ZIKV infection and its asso...

    Authors: Eric Osoro, Irene Inwani, Cyrus Mugo, Elizabeth Hunsperger, Jennifer R. Verani, Victor Omballa, Dalton Wamalwa, Chulwoo Rhee, Ruth Nduati, John Kinuthia, Hafsa Jin, Lydia Okutoyi, Dufton Mwaengo, Brian Maugo, Nancy A. Otieno, Harriet Mirieri…
    Citation: BMC Medicine 2022 20:291
  3. Preeclampsia (PE) is a multisystemic maternal syndrome with substantial maternal and fetal morbidity and mortality. Currently, there is no clinically viable non-invasive biomarker assay for early detection, th...

    Authors: Siqi Bao, Tong Zhou, Congcong Yan, Jiale Bao, Fan Yang, Shan Chao, Meng Zhou and Zhangye Xu
    Citation: BMC Medicine 2022 20:303
  4. There has been a renewed interest in the role of dietary therapies to manage irritable bowel syndrome (IBS), with diet high on the agenda for patients. Currently, interest has focussed on the use of traditiona...

    Authors: A. Rej, A. Avery, I. Aziz, C. J. Black, R. K. Bowyer, R. L. Buckle, L. Seamark, C. C. Shaw, J. Thompson, N. Trott, M. Williams and D. S. Sanders
    Citation: BMC Medicine 2022 20:287
  5. Knee osteoarthritis is the most prevalent chronic musculoskeletal debilitating disease. Current treatments are only symptomatic, and to improve this, we need a robust prediction model to stratify patients at a...

    Authors: Hossein Bonakdari, Jean-Pierre Pelletier, Francisco J. Blanco, Ignacio Rego-Pérez, Alejandro Durán-Sotuela, Dawn Aitken, Graeme Jones, Flavia Cicuttini, Afshin Jamshidi, François Abram and Johanne Martel-Pelletier
    Citation: BMC Medicine 2022 20:316
  6. Observational studies have reported maternal short/long sleep duration to be associated with adverse pregnancy and perinatal outcomes. However, it remains unclear whether there are nonlinear causal effects. Ou...

    Authors: Qian Yang, Maria C. Magnus, Fanny Kilpi, Gillian Santorelli, Ana Gonçalves Soares, Jane West, Per Magnus, John Wright, Siri Eldevik Håberg, Eleanor Sanderson, Deborah A. Lawlor, Kate Tilling and Maria Carolina Borges
    Citation: BMC Medicine 2022 20:295
  7. Grip strength is a widely used and well-validated measure of overall health that is increasingly understood to index risk for psychiatric illness and neurodegeneration in older adults. However, existing work h...

    Authors: Rongtao Jiang, Margaret L. Westwater, Stephanie Noble, Matthew Rosenblatt, Wei Dai, Shile Qi, Jing Sui, Vince D. Calhoun and Dustin Scheinost
    Citation: BMC Medicine 2022 20:286
  8. High-grade serous carcinoma (HGSC) is the most frequent and lethal type of ovarian cancer. It has been proposed that tubal secretory cells are the origin of ovarian HGSC in women with familial BRCA1/2 mutations. ...

    Authors: Xuexin Yu, Wanrun Lin, Alexandra Spirtos, Yan Wang, Hao Chen, Jianfeng Ye, Jessica Parker, Ci Ci Liu, Yiying Wang, Gabriella Quinn, Feng Zhou, Setsuko K. Chambers, Cheryl Lewis, Jayanthi Lea, Bo Li and Wenxin Zheng
    Citation: BMC Medicine 2022 20:283
  9. Multimorbidity poses a major challenge for care coordination. However, data on what non-communicable diseases lead to multimorbidity, and whether the lifetime risk differs between men and women are lacking. We...

    Authors: Premysl Velek, Annemarie I. Luik, Guy G. O. Brusselle, Bruno Ch. Stricker, Patrick J. E. Bindels, Maryam Kavousi, Brenda C. T. Kieboom, Trudy Voortman, Rikje Ruiter, M. Arfan Ikram, M. Kamran Ikram, Evelien I. T. de Schepper and Silvan Licher
    Citation: BMC Medicine 2022 20:304
  10. In China, colorectal cancer (CRC) incidence and mortality have been steadily increasing over the last decades. Risk models to predict incident CRC have been developed in various populations, but they have not ...

    Authors: Roxanna E. Abhari, Blake Thomson, Ling Yang, Iona Millwood, Yu Guo, Xiaoming Yang, Jun Lv, Daniel Avery, Pei Pei, Peng Wen, Canqing Yu, Yiping Chen, Junshi Chen, Liming Li, Zhengming Chen and Christiana Kartsonaki
    Citation: BMC Medicine 2022 20:302
  11. Recent studies have reported improved diastolic function in patients administered sodium-glucose cotransporter 2 inhibitors (SGLT2i). We aimed to investigate the effect of dapagliflozin on left ventricular (LV...

    Authors: Seul-Gee Lee, Darae Kim, Jung-Jae Lee, Hyun-Ju Lee, Ro-kyung Moon, Yong-Joon Lee, Seung-Jun Lee, Oh-Hyun Lee, Choongki Kim, Jaewon Oh, Chan Joo Lee, Yong-ho Lee, Seil Park, Ok-Hee Jeon, Donghoon Choi, Geu-Ru Hong…
    Citation: BMC Medicine 2022 20:309
  12. Onchocerciasis is a disease caused by infection with Onchocerca volvulus, which is transmitted to humans via the bite of several species of black fly, and is responsible for permanent blindness or vision loss, as...

    Authors: Chris A. Schmidt, Elizabeth A. Cromwell, Elex Hill, Katie M. Donkers, Megan F. Schipp, Kimberly B. Johnson, David M. Pigott and Simon I. Hay
    Citation: BMC Medicine 2022 20:293
  13. Studies on physical activity (PA) and mental health are largely limited to self-reported PA. This study aims to use prospective cohort data to investigate the association between device-measured PA and affecti...

    Authors: Frederick K. Ho, Fanny Petermann-Rocha, Solange Parra-Soto, Jirapitcha Boonpor, Jason M. R. Gill, Stuart R. Gray, Jill P. Pell and Carlos Celis-Morales
    Citation: BMC Medicine 2022 20:290
  14. Beta-blocker (BB) and calcium channel blocker (CCB) antihypertensive drugs are commonly used in pregnancy. However, data on their relative impact on maternal and foetal outcomes are limited. We leveraged genet...

    Authors: Maddalena Ardissino, Eric A. W. Slob, Skanda Rajasundaram, Rohin K. Reddy, Benjamin Woolf, Joanna Girling, Mark R. Johnson, Fu Siong Ng and Dipender Gill
    Citation: BMC Medicine 2022 20:288
  15. How much scientific evidence is there to show that stem cell therapy is sufficient in preclinical and clinical studies of spinal cord injury before it is translated into clinical practice? This is a complicate...

    Authors: Zhizhong Shang, Mingchuan Wang, Baolin Zhang, Xin Wang and Pingping Wanyan
    Citation: BMC Medicine 2022 20:284
  16. Some occult hepatitis B virus (HBV) infections are resulted from PreS mutations that reduce secretion of envelope protein (HBsAg). We investigated the ceramide amounts and species in hepatocytes infected with ...

    Authors: Chang Liu, Kun Chen, Fei Zhao, Lingling Xuan, Yuting Wang, Chungui Xu, Zhiyuan Wu, Dongmei Wang and Chunfeng Qu
    Citation: BMC Medicine 2022 20:279
  17. Clinical complexity is increasingly prevalent among patients with atrial fibrillation (AF). The ‘Atrial fibrillation Better Care’ (ABC) pathway approach has been proposed to streamline a more holistic and inte...

    Authors: Giulio Francesco Romiti, Marco Proietti, Marco Vitolo, Niccolò Bonini, Ameenathul Mazaya Fawzy, Wern Yew Ding, Laurent Fauchier, Francisco Marin, Michael Nabauer, Gheorghe Andrei Dan, Tatjana S. Potpara, Giuseppe Boriani and Gregory Y. H. Lip
    Citation: BMC Medicine 2022 20:326
  18. Adolescent obesity has been reported to have deleterious consequences but is considered a promising modifiable risk factor. We aimed to investigate the optimal intervention for obese and overweight children an...

    Authors: Jing Hong Liang, Yu Zhao, Yi Can Chen, Nan Jiang, Shu Xin Zhang, Shan Huang, Aerziguli Kakaer and Ya Jun Chen
    Citation: BMC Medicine 2022 20:325
  19. Acute kidney injury (AKI) is frequently associated with COVID-19, and the need for kidney replacement therapy (KRT) is considered an indicator of disease severity. This study aimed to develop a prognostic scor...

    Authors: Flávio de Azevedo Figueiredo, Lucas Emanuel Ferreira Ramos, Rafael Tavares Silva, Daniela Ponce, Rafael Lima Rodrigues de Carvalho, Alexandre Vargas Schwarzbold, Amanda de Oliveira Maurílio, Ana Luiza Bahia Alves Scotton, Andresa Fontoura Garbini, Bárbara Lopes Farace, Bárbara Machado Garcia, Carla Thais Cândida Alves da Silva, Christiane Corrêa Rodrigues Cimini, Cíntia Alcantara de Carvalho, Cristiane dos Santos Dias, Daniel Vitório Silveira…
    Citation: BMC Medicine 2022 20:324
  20. Use of kinase inhibitors such as dasatinib and imatinib might increase the risk of opportunistic infections, especially Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infections. However, the effect of sor...

    Authors: Xin Xu, Zhiping Fan, Yu Wang, Fen Huang, Yajing Xu, Jing Sun, Na Xu, Lan Deng, Xudong Li, Xinquan Liang, Xiaodan Luo, Pengcheng Shi, Hui Liu, Yan Chen, Sanfang Tu, Xiaojun Huang…
    Citation: BMC Medicine 2022 20:282
  21. COVID-19 vaccines have been crucial in the pandemic response and understanding changes in vaccines effectiveness is essential to guide vaccine policies. Although the Delta variant is no longer dominant, unders...

    Authors: Jostein Starrfelt, Anders Skyrud Danielsen, Eirik Alnes Buanes, Lene Kristine Juvet, Trude Marie Lyngstad, Gunnar Øyvind Isaksson Rø, Lamprini Veneti, Sara Viksmoen Watle and Hinta Meijerink
    Citation: BMC Medicine 2022 20:278
  22. To examine the association between regular use of proton pump inhibitors and the risk of incident dementia, including dementia subtypes, and whether the association differs between APOE genotypes.

    Authors: Peidong Zhang, Zhihao Li, Peiliang Chen, Ao Zhang, Yu Zeng, Xiru Zhang, Qingmei Huang, Dan Liu, Songtao Qi and Chen Mao
    Citation: BMC Medicine 2022 20:271
  23. Observational studies have revealed that type 2 diabetes (T2D) is associated with an increased risk of peripheral artery disease (PAD). However, whether the two diseases share a genetic basis and whether the r...

    Authors: Xuehao Xiu, Haoyang Zhang, Angli Xue, David N. Cooper, Li Yan, Yuedong Yang, Yuanhao Yang and Huiying Zhao
    Citation: BMC Medicine 2022 20:300
  24. Tackling problematic polypharmacy requires tailoring the use of medicines to individual circumstances and may involve the process of deprescribing. Deprescribing can cause anxiety and concern for clinicians an...

    Authors: Amadea Turk, Geoffrey Wong, Kamal R. Mahtani, Michelle Maden, Ruaraidh Hill, Ed Ranson, Emma Wallace, Janet Krska, Dee Mangin, Richard Byng, Daniel Lasserson and Joanne Reeve
    Citation: BMC Medicine 2022 20:297

    The Correction to this article has been published in BMC Medicine 2022 20:401

  25. Polycystic ovary syndrome (PCOS) affects up to one in five women of childbearing age. Observational studies assessing the association between maternal PCOS and adverse obstetric outcomes have reported varying ...

    Authors: Anuradhaa Subramanian, Siang Ing Lee, Katherine Phillips, Konstantinos A. Toulis, Punith Kempegowda, Michael W. O’Reilly, Nicola J. Adderley, Shakila Thangaratinam, Wiebke Arlt and Krishnarajah Nirantharakumar
    Citation: BMC Medicine 2022 20:298
  26. Frailty is a medical syndrome that is strongly associated with mortality risk and an emerging global health burden. Mental disorders are associated with reduced life expectancy and elevated levels of frailty. ...

    Authors: Julian Mutz, Umamah Choudhury, Jinlong Zhao and Alexandru Dregan
    Citation: BMC Medicine 2022 20:274
  27. Although targeted agents have been gradually applied in the treatment of HER2-mutated non-small cell lung cancer (NSCLC) in recent years, patients’ therapeutic demands are far from being met. PATHER2 was the firs...

    Authors: Guangjian Yang, Haiyan Xu, Yaning Yang, Shuyang Zhang, Fei Xu, Xuezhi Hao, Junling Li, Puyuan Xing, Xingsheng Hu, Yutao Liu, Lin Wang, Lin Lin, Zhijie Wang, Jianchun Duan, Jie Wang and Yan Wang
    Citation: BMC Medicine 2022 20:277
  28. Accurate diagnosis of unexplained cervical lymphadenopathy (CLA) using medical images heavily relies on the experience of radiologists, which is even worse for CLA patients in underdeveloped countries and regi...

    Authors: Yangyang Zhu, Zheling Meng, Xiao Fan, Yin Duan, Yingying Jia, Tiantian Dong, Yanfang Wang, Juan Song, Jie Tian, Kun Wang and Fang Nie
    Citation: BMC Medicine 2022 20:269
  29. RTS,S is the first malaria vaccine recommended for implementation among young children at risk. However, vaccine efficacy is modest and short-lived. Antibodies play the major role in vaccine-induced immunity, ...

    Authors: Gaoqian Feng, Liriye Kurtovic, Paul A. Agius, Elizabeth H. Aitken, Jahit Sacarlal, Bruce D. Wines, P. Mark Hogarth, Stephen J. Rogerson, Freya J. I. Fowkes, Carlota Dobaño and James G. Beeson
    Citation: BMC Medicine 2022 20:289
  30. There are no proven tumor biomarkers for the early diagnosis of clear cell renal cell carcinoma (ccRCC) thus far. This study aimed to identify novel biomarkers of ccRCC based on exosomal mRNA (emRNA) profiling...

    Authors: Xing He, Feng Tian, Fei Guo, Fangxing Zhang, Huiyong Zhang, Jin Ji, Lin Zhao, Jingyi He, Yutian Xiao, Longman Li, Chunmeng Wei, Caihong Huang, Yexin Li, Feng Zhang, Bo Yang, Huamao Ye…
    Citation: BMC Medicine 2022 20:270
  31. Non-medical issues (e.g. loneliness, financial concerns, housing problems) can shape how people feel physically and psychologically. This has been emphasised during the Covid-19 pandemic, especially for older ...

    Authors: Stephanie Tierney, Sebastien Libert, Jordan Gorenberg, Geoff Wong, Amadea Turk, Kerryn Husk, Helen J. Chatterjee, Kathryn Eccles, Caroline Potter, Emma Webster, Beth McDougall, Harriet Warburton, Lucy Shaw, Nia Roberts and Kamal R. Mahtani
    Citation: BMC Medicine 2022 20:260
  32. Gastrointestinal stromal tumor (GIST) is a rare type of cancer that occurs in the gastrointestinal tract. The majority of GIST cases carry oncogenic forms of KIT, the receptor for stem cell factor (SCF). Small...

    Authors: Dengyang Zhang, Chunxiao He, Yao Guo, Jianfeng Li, Bo Li, Yuming Zhao, Liuting Yu, Zhiguang Chang, Hanzhong Pei, Ming Yang, Na Li, Qi Zhang, Yulong He, Yihang Pan, Zhizhuang Joe Zhao, Changhua Zhang…
    Citation: BMC Medicine 2022 20:257
  33. Whether a genetic predisposition to psychiatric disorders is associated with coronavirus disease 2019 (COVID-19) is unknown.

    Authors: Wenwen Chen, Yu Zeng, Chen Suo, Huazhen Yang, Yilong Chen, Can Hou, Yao Hu, Zhiye Ying, Yajing Sun, Yuanyuan Qu, Donghao Lu, Fang Fang, Unnur A. Valdimarsdóttir and Huan Song
    Citation: BMC Medicine 2022 20:314
  34. Significant intertumoral heterogeneity exists as antitumor treatment is introduced. Heterogeneous therapeutic responses are conventionally evaluated by imaging examinations based on Response Evaluation Criteri...

    Authors: Jiawei Lv, Chenfei Wu, Junyan Li, Foping Chen, Shiwei He, Qingmei He, Guanqun Zhou, Jun Ma, Ying Sun, Denghui Wei and Li Lin
    Citation: BMC Medicine 2022 20:268
  35. The Sepsis-3 criteria introduced the system that uses the Sequential Organ-Failure Assessment (SOFA) score to define sepsis. The cardiovascular SOFA (CV SOFA) scoring system needs modification due to the chang...

    Authors: Hui Jai Lee, Byuk Sung Ko, Seung Mok Ryoo, Eunah Han, Gil Joon Suh, Sung-Hyuk Choi, Sung Phil Chung, Tae Ho Lim, Won Young Kim, Woon Yong Kwon, Sung Yeon Hwang, You Hwan Jo, Jonghwan Shin, Tae Gun Shin and Kyuseok Kim
    Citation: BMC Medicine 2022 20:263
  36. The relationship between non-alcoholic fatty liver degree as well as non-alcoholic fatty liver disease (NAFLD) and irritable bowel syndrome (IBS) remains poorly understood. We aimed to investigate the prospect...

    Authors: Shanshan Wu, Changzheng Yuan, Zhirong Yang, Si Liu, Qian Zhang, Shutian Zhang and Shengtao Zhu
    Citation: BMC Medicine 2022 20:262
  37. The Kin-Antwerp project aimed at improving the quality of care provided to patients with diabetes in Kinshasa, the Democratic Republic of the Congo in Central Africa, including the digitalisation of routine cl...

    Authors: Diana Sagastume, Elly Mertens, Deogratias Katsuva Sibongwere, Jean-Claude Dimbelolo, Jean Clovis Kalobu Kabundi, Jeroen de Man, Josefien Van Olmen and José L. Peñalvo
    Citation: BMC Medicine 2022 20:258
  38. Although the association between beverages and a single cardiometabolic disease has been well studied, their role in disease progression from the single cardiometabolic disease state to cardiometabolic multimo...

    Authors: Yi Luo, Lingfang He, Tianqi Ma, Jinchen Li, Yongping Bai, Xunjie Cheng and Guogang Zhang
    Citation: BMC Medicine 2022 20:273
  39. Periprostatic adipose tissue (PPAT) plays a role in prostate cancer (PCa) progression. PPAT lipidomic composition study may allow us to understand the tumor metabolic microenvironment and provide new stratific...

    Authors: Antonio Altuna-Coy, Xavier Ruiz-Plazas, Silvia Sánchez-Martin, Helena Ascaso-Til, Manuel Prados-Saavedra, Marta Alves-Santiago, Xana Bernal-Escoté, José Segarra-Tomás and Matilde R. Chacón
    Citation: BMC Medicine 2022 20:255
  40. Women experience adverse changes in cardiovascular health in mid-life; whether the menopausal transition influences these remains strongly debated. The aim of this study was to examine associations of reproduc...

    Authors: Gemma L. Clayton, Ana Gonçalves Soares, Fanny Kilpi, Abigail Fraser, Paul Welsh, Naveed Sattar, Scott M. Nelson, Kate Tilling and Deborah A. Lawlor
    Citation: BMC Medicine 2022 20:299
  41. Smoking is a major risk factor for cardiovascular disease and smoking cessation reduces excess risk. E-cigarettes are popular for smoking cessation but there is little evidence on their cardiovascular health e...

    Authors: Markos Klonizakis, Anil Gumber, Emma McIntosh and Leonie S. Brose
    Citation: BMC Medicine 2022 20:276
  42. During the COVID-19 pandemic, there have been concerns regarding potential bias in pulse oximetry measurements for people with high levels of skin pigmentation. We systematically reviewed the effects of skin p...

    Authors: Chunhu Shi, Mark Goodall, Jo Dumville, James Hill, Gill Norman, Oliver Hamer, Andrew Clegg, Caroline Leigh Watkins, George Georgiou, Alexander Hodkinson, Catherine Elizabeth Lightbody, Paul Dark and Nicky Cullum
    Citation: BMC Medicine 2022 20:267
  43. Plasma metabolomic profile is disturbed in dementia patients, but previous studies have discordant conclusions.

    Authors: Xinyu Zhang, Wenyi Hu, Yueye Wang, Wei Wang, Huan Liao, Xiayin Zhang, Katerina V. Kiburg, Xianwen Shang, Gabriella Bulloch, Yu Huang, Xueli Zhang, Shulin Tang, Yijun Hu, Honghua Yu, Xiaohong Yang, Mingguang He…
    Citation: BMC Medicine 2022 20:252
  44. Maternal smoking during pregnancy was reported to be associated with a reduced risk of type 1 diabetes in the offspring. We investigated whether this association is consistent with a causal interpretation by a...

    Authors: Yuxia Wei, Tomas Andersson, Jessica Edstorp, Josefin E. Löfvenborg, Mats Talbäck, Maria Feychting and Sofia Carlsson
    Citation: BMC Medicine 2022 20:240

    The Commentary to this article has been published in BMC Medicine 2022 20:296

  45. The risk of hip fracture in women on plant-based diets is unclear. We aimed to investigate the risk of hip fracture in occasional meat-eaters, pescatarians, and vegetarians compared to regular meat-eaters in t...

    Authors: James Webster, Darren C. Greenwood and Janet E. Cade
    Citation: BMC Medicine 2022 20:275
  46. Interleukin 6 (IL-6) signaling is being investigated as a therapeutic target for atherosclerotic cardiovascular disease (CVD). While changes in circulating high-sensitivity C-reactive protein (hsCRP) are used ...

    Authors: Marios K. Georgakis, Rainer Malik, Tom G. Richardson, Joanna M. M. Howson, Christopher D. Anderson, Stephen Burgess, G. Kees Hovingh, Martin Dichgans and Dipender Gill
    Citation: BMC Medicine 2022 20:245