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  1. Providing informal care for a person with Parkinson’s disease (PD) can be a demanding process affecting several dimensions of a caregiver’s life and potentially causing caregiver burden. Despite the emerging l...

    Authors: Angelika D. Geerlings, Willanka M. Kapelle, Charlotte J. Sederel, Emma Tenison, Hilde Wijngaards-Berenbroek, Marjan J. Meinders, Marten Munneke, Yoav Ben-Shlomo, Bastiaan R. Bloem and Sirwan K. L. Darweesh
    Citation: BMC Medicine 2023 21:247
  2. Early phase dose-finding (EPDF) trials are crucial for the development of a new intervention and influence whether it should be investigated in further trials. Guidance exists for clinical trial protocols and ...

    Authors: Olga Solovyeva, Munyaradzi Dimairo, Christopher J. Weir, Siew Wan Hee, Aude Espinasse, Moreno Ursino, Dhrusti Patel, Andrew Kightley, Sarah Hughes, Thomas Jaki, Adrian Mander, Thomas R. Jeffry Evans, Shing Lee, Sally Hopewell, Khadija Rerhou Rantell, An-Wen Chan…
    Citation: BMC Medicine 2023 21:246
  3. Due to the asymptomatic nature of the early stages, chronic kidney disease (CKD) is usually diagnosed at late stages and lacks targeted therapy, highlighting the need for new biomarkers to better understand it...

    Authors: Jie-sheng Lin, Jana Nano, Agnese Petrera, Stefanie M. Hauck, Tanja Zeller, Wolfgang Koenig, Christian L. Müller, Annette Peters and Barbara Thorand
    Citation: BMC Medicine 2023 21:245
  4. Vaping cessation is virtually unexplored. The efficacy and safety of varenicline for vaping cessation has not been studied and rigorous research is required to advance best practice and outcomes for people who...

    Authors: Pasquale Caponnetto, Davide Campagna, Jasjit S. Ahluwalia, Christopher Russell, Marilena Maglia, Paolo Marco Riela, Carmelo Fabio Longo, Barbara Busa and Riccardo Polosa
    Citation: BMC Medicine 2023 21:220
  5. Randomised controlled trials are often beset by problems with poor recruitment and retention. Information to support decisions on trial participation is usually provided as printed participant information shee...

    Authors: Peter Knapp, Thirimon Moe-Byrne, Jacqueline Martin-Kerry, Rebecca Sheridan, Jenny Roche, Elizabeth Coleman, Peter Bower, Steven Higgins, Catherine Stones, Jonathan Graffy, Jenny Preston, Carrol Gamble, Bridget Young, Daniel Perry, Annegret Dahlmann-Noor, Mohamed Abbas…
    Citation: BMC Medicine 2023 21:244
  6. Elimination of mother-to-child transmission of hepatitis B virus (HBV) requires infant immunoprophylaxis and antiviral prophylaxis for pregnant women with high viral loads. Since real-time polymerase chain rea...

    Authors: Yasir Shitu Isa, Jonathan Sicsic, Henry Njuguna, John Ward, Mohamed Chakroun, Mohamed El-Kassas, Rado Ramanampamonjy, Salim Chalal, Jeanne Perpétue Vincent, Monique Andersson, Hailemichael Desalegn, Fatou Fall, Asgeir Johannessen, Philippa C. Matthews, Gibril Ndow, Edith Okeke…
    Citation: BMC Medicine 2023 21:243
  7. Several economic obstacles can deter the development and use of vaccines. This can lead to limited product options for some diseases, delays in new product development, and inequitable access to vaccines. Alth...

    Authors: Raymond Hutubessy, Jeremy A. Lauer, Birgitte Giersing, So Yoon Sim, Mark Jit, David Kaslow and Siobhan Botwright
    Citation: BMC Medicine 2023 21:229
  8. Whether diet has beneficial effects on cardiovascular disease (CVD) in childhood cancer survivors as in the general population is unknown. Therefore, we examined associations between dietary patterns and risk ...

    Authors: Tuo Lan, Mei Wang, Matthew J. Ehrhardt, Shu Jiang, Jennifer Q. Lanctot, Gregory T. Armstrong, Melissa M. Hudson, Graham A. Colditz, Leslie L. Robison and Yikyung Park
    Citation: BMC Medicine 2023 21:242
  9. The development of machine learning models for aiding in the diagnosis of mental disorder is recognized as a significant breakthrough in the field of psychiatry. However, clinical practice of such models remai...

    Authors: Zhiyi Chen, Bowen Hu, Xuerong Liu, Benjamin Becker, Simon B. Eickhoff, Kuan Miao, Xingmei Gu, Yancheng Tang, Xin Dai, Chao Li, Artemiy Leonov, Zhibing Xiao, Zhengzhi Feng, Ji Chen and Hu Chuan-Peng
    Citation: BMC Medicine 2023 21:241
  10. Breast cancer (BC) is the most common cancer type in women. The purpose of this study was to assess the eligibility criteria in recent clinical trials in BC, especially those that can limit the enrollment of o...

    Authors: Katarzyna Szlezinger, Katarzyna Pogoda, Agnieszka Jagiełło-Gruszfeld, Danuta Kłosowska, Andrzej Górski and Jan Borysowski
    Citation: BMC Medicine 2023 21:240
  11. It is unclear whether dobutamine, commonly used clinically in echocardiography and short-term congestive heart failure treatment for promoting increased myocardial contractility, affects brain microcirculatory...

    Authors: Tingting Zhang, Haijun Niu, Yawen Liu, Linkun Cai, Dong Liu, Erwei Zhao, Min Li, Wenjuan Liu, Jing Li, PengGang Qiao, Wei Zheng, Pengling Ren and Zhenchang Wang
    Citation: BMC Medicine 2023 21:238
  12. Schizophrenia is characterized by complex psychiatric symptoms and unclear pathological mechanisms. Most previous studies have focused on the morphological changes that occur over the development of the diseas...

    Authors: Sisi Jiang, Huan Huang, Jingyu Zhou, Hechun Li, Mingjun Duan, Dezhong Yao and Cheng Luo
    Citation: BMC Medicine 2023 21:237
  13. Primary care has been described as the ‘bedrock’ of the National Health Service (NHS) accounting for approximately 90% of patient contacts but is facing significant challenges. Against a backdrop of a rapidly ...

    Authors: Alexandra Jager, Geoff Wong, Chrysanthi Papoutsi and Nia Roberts
    Citation: BMC Medicine 2023 21:236
  14. Asialoglycoprotein receptor 1 (ASGR1) is emerging as a potential drug target to reduce low-density lipoprotein (LDL)-cholesterol and coronary artery disease (CAD) risk. Here, we investigated genetically mimick...

    Authors: Guoyi Yang and C. Mary Schooling
    Citation: BMC Medicine 2023 21:235
  15. In addition to improving survival outcomes, new oncology treatments should lead to amelioration of patients’ quality of life (QoL). Herein, we examined whether QoL results correlated with PFS and OS outcomes i...

    Authors: Alberto Servetto, Massimo Di Maio, Fabio Salomone, Fabiana Napolitano, Chiara Paratore, Fabrizio Di Costanzo, Giuseppe Viscardi, Antonio Santaniello, Luigi Formisano and Roberto Bianco
    Citation: BMC Medicine 2023 21:234
  16. Several COVID-19 vaccines are in widespread use in China. Few data exist on comparative immunogenicity of different COVID-19 vaccines given as booster doses. We aimed to assess neutralizing antibody levels rai...

    Authors: Fuzhen Wang, Baoying Huang, Yao Deng, Shaobai Zhang, Xiaoqiang Liu, Lei Wang, Qianqian Liu, Li Zhao, Lin Tang, Wenling Wang, Xiaoqi Wang, Fei Ye, Weijun Hu, Haitao Yang, Siquan Wang, Jiao Ren…
    Citation: BMC Medicine 2023 21:233
  17. Post-acute care (PAC) services after hospitalization for hip fracture are typically provided in skilled nursing facilities (SNFs), inpatient rehabilitation facilities (IRFs), or at home via home health care (H...

    Authors: Melissa R. Riester, Francesca L. Beaudoin, Richa Joshi, Kaleen N. Hayes, Meghan A. Cupp, Sarah D. Berry and Andrew R. Zullo
    Citation: BMC Medicine 2023 21:232
  18. A dysregulated postprandial metabolic response is a risk factor for chronic diseases, including type 2 diabetes mellitus (T2DM). The plasma protein N-glycome is implicated in both lipid metabolism and T2DM ris...

    Authors: Panayiotis Louca, Tamara Štambuk, Azra Frkatović-Hodžić, Ana Nogal, Massimo Mangino, Sarah E. Berry, Helena Deriš, George Hadjigeorgiou, Jonathan Wolf, Martina Vinicki, Paul W. Franks, Ana M. Valdes, Tim D. Spector, Gordan Lauc and Cristina Menni
    Citation: BMC Medicine 2023 21:231
  19. Surgery is a common treatment strategy for patients with neurofibromatosis type 1 (NF1)-related plexiform neurofibroma (PN) and has limited efficacy. FCN-159 is a novel anti-tumorigenic drug via selective inhi...

    Authors: Xiaojie Hu, Wenbin Li, Kang Zeng, Zhongyuan Xu, Changxing Li, Zhuang Kang, Shenglan Li, Xin Huang, Pu Han, Hongmei Lin, Ai-Min Hui, Yan Tan, Lei Diao, Ben Li, Xingli Wang, Zhuli Wu…
    Citation: BMC Medicine 2023 21:230
  20. Pneumonia is a common disease worldwide in preschool children. Despite its large population size, China has had no comprehensive study of the national prevalence, risk factors, and management of pneumonia amon...

    Authors: Haonan Shi, Tingting Wang, Zhuohui Zhao, Dan Norback, Xiaowei Wang, Yongsheng Li, Qihong Deng, Chan Lu, Xin Zhang, Xiaohong Zheng, Hua Qian, Ling Zhang, Wei Yu, Yuqing Shi, Tianyi Chen, Huaijiang Yu…
    Citation: BMC Medicine 2023 21:227
  21. Human epidermal growth factor receptor 2 (HER2) targeted therapy combined with endocrine therapy has been recommended as an alternative treatment strategy for patients with hormone receptor (HR)-positive, HER2...

    Authors: Zhe-Yu Hu, Min Yan, Huihua Xiong, Li Ran, Jincai Zhong, Ting Luo, Tao Sun, Ning Xie, Liping Liu, Xiaohong Yang, Huawu Xiao, Jing Li, Binliang Liu and Quchang Ouyang
    Citation: BMC Medicine 2023 21:226
  22. The Mediterranean diet has been associated with lower risk of breast cancer (BC) but evidence from prospective studies on the role of Mediterranean diet on BC survival remains sparse and conflicting. We aimed ...

    Authors: Carlota Castro-Espin, Catalina Bonet, Marta Crous-Bou, Núria Nadal-Zaragoza, Anne Tjønneland, Lene Mellemkjær, Mariem Hajji-Louati, Thérèse Truong, Verena Katzke, Charlotte Le Cornet, Matthias B. Schulze, Franziska Jannasch, Giovanna Masala, Sabina Sieri, Salvatore Panico, Chiara Di Girolamo…
    Citation: BMC Medicine 2023 21:225
  23. Statistical modelling studies based on excess morbidity and mortality are important for understanding RSV disease burden for age groups that are less frequently tested for RSV. We aimed to understand the full ...

    Authors: Bingbing Cong, Izzie Dighero, Tiantian Zhang, Alexandria Chung, Harish Nair and You Li
    Citation: BMC Medicine 2023 21:224
  24. The identification of pathogenic mutations in Alzheimer’s disease (AD) causal genes led to a better understanding of the pathobiology of AD. Familial Alzheimer’s disease (FAD) is known to be associated with mu...

    Authors: Wenwen Li, Yana Pang, Yan Wang, Fan Mei, Mengmeng Guo, Yiping Wei, Xinyue Li, Wei Qin, Wei Wang, Longfei Jia and Jianping Jia
    Citation: BMC Medicine 2023 21:223
  25. Understanding the temporal trends in the burden of overall and type-specific cardiovascular diseases (CVDs) in youths and young adults and its attributable risk factors is important for effective and targeted ...

    Authors: Jiahong Sun, Yanan Qiao, Min Zhao, Costan G. Magnussen and Bo Xi
    Citation: BMC Medicine 2023 21:222

    The Comment to this article has been published in BMC Global and Public Health 2023 1:14

  26. Although many conventional healthcare services to prevent postpartum depression are provided face-to-face, physical and psychosocial barriers remain. These barriers may be overcome by using mobile health servi...

    Authors: Yuki Arakawa, Maho Haseda, Kosuke Inoue, Daisuke Nishioka, Shiho Kino, Daisuke Nishi, Hideki Hashimoto and Naoki Kondo
    Citation: BMC Medicine 2023 21:221
  27. Currently, the main pharmaceutical intervention for COVID-19 is vaccination. While antidepressant (AD) drugs have shown some efficacy in treatment of symptomatic COVID-19, their preventative potential remains ...

    Authors: Oleg O. Glebov, Christoph Mueller, Robert Stewart, Dag Aarsland and Gayan Perera
    Citation: BMC Medicine 2023 21:209
  28. Since the beginning of the COVID-19 vaccination campaigns, recommendations regarding the vaccination have been very dynamic. Although the safety and efficacy of different vaccines have been analysed, data were...

    Authors: Lisette Warkentin, Felix Werner, Nikoletta Zeschick, Thomas Kühlein, Philipp Steininger, Klaus Überla, Isabelle Kaiser, Maria Sebastião and Susann Hueber
    Citation: BMC Medicine 2023 21:218
  29. High-sensitivity cardiac troponin testing is a promising tool for cardiovascular risk prediction, but whether serial testing can dynamically predict risk is uncertain. We evaluated the trajectory of cardiac tr...

    Authors: Dorien M. Kimenai, Atul Anand, Marie de Bakker, Martin Shipley, Takeshi Fujisawa, Magnus N. Lyngbakken, Kristian Hveem, Torbjørn Omland, Carlos A. Valencia-Hernández, Joni V. Lindbohm, Mika Kivimaki, Archana Singh-Manoux, Fiona E. Strachan, Anoop S. V. Shah, Isabella Kardys, Eric Boersma…
    Citation: BMC Medicine 2023 21:216
  30. Articular injection of mesenchymal stem cells (MSCs) has been applied to treat knee osteoarthritis (kOA), but its clinical outcomes are controversial. This study investigated whether an articular inflammatory ...

    Authors: Mengqiang Fan, Peijian Tong, Li Yan, Ting Li, Jiadan Ren, Jiefeng Huang, Wenxi Du, Li Zhou and Letian Shan
    Citation: BMC Medicine 2023 21:215
  31. A workplace-based primary prevention intervention be an effective approach to reducing the incidence of hypertension (HTN). However, few studies to date have addressed the effect among the Chinese working popu...

    Authors: Zhen Hu, Xin Wang, Conglin Hong, Congyi Zheng, Linfeng Zhang, Zuo Chen, Haoqi Zhou, Yixin Tian, Xue Cao, Jiayin Cai, Runqing Gu, Ye Tian, Lan Shao and Zengwu Wang
    Citation: BMC Medicine 2023 21:214
  32. Genomic technologies have become routine in the surveillance and monitoring of the coronavirus disease 2019 (COVID-19) pandemic, as evidenced by the millions of SARS-CoV-2 sequences uploaded to international d...

    Authors: Michael Bunce, Jemma L. Geoghegan, David Winter, Joep de Ligt and Siouxsie Wiles
    Citation: BMC Medicine 2023 21:213
  33. There are few large-scale studies evaluating the safety of the sodium-glucose cotransporter-2 inhibitor, dapagliflozin, in Chinese patients with type 2 diabetes. DONATE, a multicentre, single-arm, prospective,...

    Authors: Lixin Guo, Jing Wang, Li Li, Lin Yuan, Sheng Chen, Hui Wang, Tonghuan Li, Lin Qi and Hong Yang
    Citation: BMC Medicine 2023 21:212
  34. Rates of diseases and death from tobacco smoking are substantially higher among those with a mental health condition (MHC). Vaping can help some people quit smoking, but little is known about vaping among peop...

    Authors: Eve Taylor, Leonie S Brose, Ann McNeill, Jamie Brown, Loren Kock and Debbie Robson
    Citation: BMC Medicine 2023 21:211
  35. The impact of immunosuppressive therapies on the efficacy of vaccines to SARS-CoV-2 is not completely clarified. We analyzed humoral and T cell-mediated response after COVID-19 mRNA vaccine in immunosuppressed...

    Authors: Federica Filippini, Mauro Giacomelli, Chiara Bazzani, Micaela Fredi, Paolo Semeraro, Cesare Tomasi, Franco Franceschini, Arnaldo Caruso, Ilaria Cavazzana and Cinzia Giagulli
    Citation: BMC Medicine 2023 21:210
  36. Despite their widespread use, the impact of commissioners’ policies for body mass index (BMI) for access to elective surgery is not clear. Policy use varies by locality, and there are concerns that these polic...

    Authors: Joanna McLaughlin, Ruth Kipping, Amanda Owen-Smith, Hugh McLeod, Samuel Hawley, J. Mark Wilkinson and Andrew Judge
    Citation: BMC Medicine 2023 21:202
  37. Previous studies have shown inconsistent findings regarding the association of light to moderate alcohol consumption with cause-specific mortality. Therefore, this study sought to examine the prospective assoc...

    Authors: Yalan Tian, Jiahui Liu, Yue Zhao, Nana Jiang, Xiao Liu, Gang Zhao and Xia Wang
    Citation: BMC Medicine 2023 21:208

    The Research article to this article has been published in BMC Medicine 2023 21:228

  38. Authors: Flávio de Azevedo Figueiredo, Lucas Emanuel Ferreira Ramos, Rafael Tavares Silva, Daniela Ponce, Rafael Lima Rodrigues de Carvalho, Alexandre Vargas Schwarzbold, Amanda de Oliveira Maurílio, Ana Luiza Bahia Alves Scotton, Andresa Fontoura Garbini, Bárbara Lopes Farace, Bárbara Machado Garcia, Carla Thais Cândida Alves da Silva, Christiane Corrêa Rodrigues Cimini, Cíntia Alcantara de Carvalho, Cristiane dos Santos Dias, Daniel Vitório Silveira…
    Citation: BMC Medicine 2023 21:207

    The original article was published in BMC Medicine 2022 20:324

  39. Hashimoto’s thyroiditis (HT) is an organ-specific autoimmune disease characterized by lymphocyte infiltration that destroys thyrocyte cells. The aim of the present study was to elucidate the role and mechanism...

    Authors: Genpeng Li, Linye He, Jing Huang, Jiaye Liu, Wenjie Chen, Jinjing Zhong, Tao Wei, Zhihui Li, Jingqiang Zhu and Jianyong Lei
    Citation: BMC Medicine 2023 21:206
  40. While cognitive impairment after stroke is common, cognitive trends before stroke are poorly understood, especially among the Chinese population who have a relatively high stroke burden. We aimed to model the ...

    Authors: Jianian Hua, Jianye Dong, Guo-Chong Chen and Yueping Shen
    Citation: BMC Medicine 2023 21:204
  41. Norway is a high-income nation with universal tax-financed health care and among the highest per person health spending in the world. This study estimates Norwegian health expenditures by health condition, age...

    Authors: Jonas Minet Kinge, Joseph L. Dieleman, Øystein Karlstad, Ann Kristin Knudsen, Søren Toksvig Klitkou, Simon I. Hay, Theo Vos, Christopher J. L. Murray and Stein Emil Vollset
    Citation: BMC Medicine 2023 21:201

    The Comment to this article has been published in BMC Global and Public Health 2023 1:23

  42. Contact sports athletes and military personnel who suffered a repetitive mild traumatic brain injury (rmTBI) are at high risk of neurodegenerative diseases such as advanced dementia and chronic traumatic encep...

    Authors: Chaonan Zhang, Cheng Wei, Xingqi Huang, Changxin Hou, Chuan Liu, Shu Zhang, Zilong Zhao, Yafan Liu, Ruiguang Zhang, Lei Zhou, Ying Li, Xubo Yuan and Jianning Zhang
    Citation: BMC Medicine 2023 21:199
  43. Determining the grade and molecular marker status of intramedullary gliomas is important for assessing treatment outcomes and prognosis. Invasive biopsy for pathology usually carries a high risk of tissue dama...

    Authors: Chao Ma, Liyang Wang, Dengpan Song, Chuntian Gao, Linkai Jing, Yang Lu, Dongkang Liu, Weitao Man, Kaiyuan Yang, Zhe Meng, Huifang Zhang, Ping Xue, Yupeng Zhang, Fuyou Guo and Guihuai Wang
    Citation: BMC Medicine 2023 21:198
  44. Microvascular complications are associated with an overtly increased risk of adverse outcomes in patients with diabetes including coronary microvascular injury which manifested as disruption of adherens juncti...

    Authors: Xuebin Zhang, Yu Duan, Xiao Zhang, Mengyuan Jiang, Wanrong Man, Yan Zhang, Dexi Wu, Jiye Zhang, Xinglong Song, Congye Li, Jie Lin and Dongdong Sun
    Citation: BMC Medicine 2023 21:197