Assessing the burden of medical impoverishment by cause: a systematic breakdown by disease in Ethiopia
© The Author(s). 2016
Received: 1 April 2016
Accepted: 16 September 2016
Published: 21 October 2016
Out-of-pocket (OOP) medical expenses often lead to catastrophic expenditure and impoverishment in low- and middle-income countries. Yet, there has been no systematic examination of which specific diseases and conditions (e.g., tuberculosis, cardiovascular disease) drive medical impoverishment, defined as OOP direct medical costs pushing households into poverty.
We used a cost and epidemiological model to propose an assessment of the burden of medical impoverishment in Ethiopia, i.e., the number of households crossing a poverty line due to excessive OOP direct medical expenses. We utilized disease-specific mortality estimates from the Global Burden of Disease study, epidemiological and cost inputs from surveys, and secondary data from the literature to produce a count of poverty cases due to OOP direct medical costs per specific condition.
In Ethiopia, in 2013, and among 20 leading causes of mortality, we estimated the burden of impoverishment due to OOP direct medical costs to be of about 350,000 poverty cases. The top three causes of medical impoverishment were diarrhea, lower respiratory infections, and road injury, accounting for 75 % of all poverty cases.
We present a preliminary attempt for the estimation of the burden of medical impoverishment by cause for high mortality conditions. In Ethiopia, medical impoverishment was notably associated with illness occurrence and health services utilization. Although currently used estimates are sensitive to health services utilization, a systematic breakdown of impoverishment due to OOP direct medical costs by cause can provide important information for the promotion of financial risk protection and equity, and subsequent design of health policies toward universal health coverage, reduction of direct OOP payments, and poverty alleviation.
KeywordsMedical impoverishment Catastrophic health expenditure Out-of-pocket costs Direct medical payments Financial risk protection Poverty Ethiopia
High out-of-pocket (OOP) medical expenses can lead to impoverishment in many low- and middle-income countries [1, 2]. Often, individuals and households resort to a variety of strategies to cope with illness-related bills such as borrowing money from peers or selling assets . Without pre-existing financing arrangements, like social insurance, household medical expenditure can often be categorized as “catastrophic” – defined as exceeding a certain fraction (e.g., 10 %) of total household expenditure [2, 4].
Well-designed health policies are critical for the minimization of financial risks tied to OOP direct medical expenses. In this respect, the World Health Organization’s 2010 World Health Report  argued for pathways to universal health coverage (UHC) accounting for the reduction of OOP direct payments and financial risk protection as one essential dimension to measure progress on the way to UHC. Likewise, the Sustainable Development Goal for health (SDG3) included a sub-target on achieving “universal health coverage, including financial risk protection and access to quality essential health services” . The prevention of medical impoverishment, defined here as OOP direct medical costs pushing households below the poverty line or leading to catastrophic medical expenditure, is a major objective of health systems and policy instruments such as insurance and public finance . Therefore, analyzing the composition of OOP direct medical payments per cause can help design health systems better at preventing such catastrophic expenditure, which have been estimated to be substantial .
In the majority of low- and middle-income countries, there is not necessarily a clear evidence base for the interventions to be covered by public finance [7, 9]. In particular, there has been no systematic examination of which specific diseases and conditions (e.g., tuberculosis, heart disease) drive OOP direct medical costs and subsequent impoverishment. Such a systematic examination could inform the design of an essential health benefits package.
Understanding the underlying composition of medical impoverishment and its disaggregation per condition can prove useful for several reasons. First, it can point to the links between disease and poverty and be used to examine the poverty consequences of epidemiological changes and guide the implementation of tailored poverty-focused policies. In this case, assessing illness-related poverty would account for all the financial implications of disease, including OOP direct medical costs (e.g., medications and consultation fees), transportation costs, and indirect costs (e.g., time and income losses); this is not the intent of this paper. Second, the disaggregation of medical impoverishment, defined as OOP direct medical costs pushing households under the poverty line, can help within the health sector in the design of appropriate policy solutions which provide high financial protection . This approach can highlight the interventions to be financed by the health sector that can prevent catastrophic medical expenditure. Thus, this paper deliberately focuses on OOP direct medical payments only, as it is one essential dimension of UHC .
We propose a preliminary analytical approach to systematically assess the burden of impoverishment due to OOP direct medical costs per condition in a given country. We intend to expose, with simplicity, a framework which we subsequently apply to estimate medical impoverishment by cause in one particular country, as an example, Ethiopia.
We built on an existing cost and epidemiological model  to assess medical impoverishment, defined as OOP direct medical costs (e.g., consultation fees, payments for medications) pushing households below a given poverty line per condition in a given country.
The model incorporated a range of parameters, including disease-specific mortality estimates (e.g., per cause of death), case fatality ratios, patient OOP direct medical costs, health services utilizations (e.g., healthcare seeking behavior, such as the probability that a person seeks care for a specific illness conditional on having that illness), and wealth inputs (e.g., household income). The model estimated the OOP direct medical costs related to a specific condition at the population level. Subsequently, it calculated the corresponding number of cases of poverty that could be attributed to OOP direct medical costs tied to that specific condition. The quantification of those medical poverty cases relied on counting the number of households crossing a defined poverty line (e.g., country poverty line) due to condition-related OOP direct medical costs.
We applied the model to the case study of Ethiopia. First, for simplicity, we selected 20 conditions established as major causes of mortality in Ethiopia (whose estimates were immediately available from the Global Burden of Disease study ), and hence deemed to likely incur substantial OOP direct medical costs. For each condition, we obtained estimated mortality, from which we derived the number of cases using a case fatality ratio (the number of cases would equal the number of disease-related deaths divided by disease-specific case fatality ratio); second, we estimated the associated OOP direct medical costs. These costs included the direct medical costs only – there was no accounting of transport costs or time losses for the affected individuals, as our study focused on catastrophic medical costs only. In addition, we accounted for health services utilization, the percentage of individuals seeking care for a specific illness conditional on having that illness, and the combination of OOP direct medical costs and utilization allowed the estimation of incurred OOP direct medical costs. Finally, using the inputs described above, supplemented by a distribution of income in the Ethiopian population, we derived the total number of poverty cases due to OOP direct medical payments that could be attributed to each of the 20 conditions in Ethiopia.
Case fatality ratio, health services utilization (e.g., probability of seeking care conditional on being sick), and out-of-pocket direct medical costs for 20 leading causes of mortality in Ethiopia
Cause of mortality
Case fatality ratio (%)
Health services utilization (%)
Out-of-pocket direct medical costs (2013 US$)
Lower respiratory infections (LRI)
27 %a; 9 %b
Preterm birth complications
Ischemic heart disease
Based on  and estimated cancer utilization, average out-of-pocket inpatient cost for breast and cervical cancer, diabetes, and cardiovascular disease
Based on diarrhea inputs and 
Based on LRI inputs and 
Chronic obstructive pulmonary disease
Based on LRI inputs and 
Based on LRI inputs and 
Second, we used health services utilization data from various sources, including Ethiopia’s Demographic and Health Survey  and additional available information from the literature. This enabled us to quantify, among the number of individuals who were ill, the fraction who used the health services specifically addressing their illness, and hence might have encountered OOP direct medical payments for that illness. For example, for diarrhea, this fraction corresponded to the percentage of patients with diarrhea seeking either outpatient or inpatient care; for TB, this fraction was derived from the case detection rate of TB (Table 1; Additional file 1: Section 1.1). For the conditions for which we did not have utilization data (e.g., ischemic heart disease, stroke, road injury), we made assumptions based on expert opinion (author STM). Services utilization included the formal health sector as expenditure data were not available for the informal sector, and this study focused on the direct payments to the formal health system.
Third, we used OOP direct medical costs data assembled through a review of the literature for each condition. Those costs included all direct medical OOP payments, including registration, diagnostic, medications, and hospital bed payments. For those conditions for which we did not have OOP direct medical costs data, we used health services provider costs data augmented by country public and private health expenditure data (national health accounts) , in order to derive modeled OOP direct medical costs borne by households for those conditions. Ethiopia’s latest national health accounts indicated that the fraction of healthcare expenditure borne OOP by households in 2011 was 2 % for HIV/AIDS, 14 % for malaria, 28 % for reproductive health conditions, 36 % for TB, 48 % for child health conditions, and 53 % for “other” conditions . We used these percentage points to derive OOP direct medical costs from health services provider costs, when needed. For example, if the provider costs were $100 for injuries (falling into the “other” category above), then $53 would be assigned as OOP direct medical costs for injuries. All costs figures were inflated to 2013 US$ using the US consumer price index time series from the World Bank .
Fourth, in assigning household income, we assumed a distribution of income in the country, as there was no such distribution readily available for Ethiopia. We derived a distribution of income drawn from a simulated gamma distribution whose shape and scale parameters were based on gross domestic product per capita (2013 US$ 505, the mean of the income distribution) and Gini coefficient (0.33) [15–17]. For each occurrence of OOP direct medical costs associated with a particular condition, we assigned an annual income extracted from the income distribution. We also used the national poverty line (about 30 % of the population was estimated to be under Ethiopia’s poverty line in 2010, corresponding to an income level of about $306) [15, 18]. Subsequently, we estimated the number of households for whom the size of OOP direct medical costs would push them below the poverty line. A poverty case was counted when first household income was above the poverty line and second household income minus OOP direct medical costs was below the poverty line (Additional file 1: Section 1.2).
We conducted both probabilistic and univariate sensitivity analyses. A probabilistic sensitivity analysis was conducted using Monte Carlo simulations (n = 1000 trials) where all key parameters (causes of death estimates, case fatality ratios, utilizations, OOP direct medical costs) were varied simultaneously. Uncertainty was included through sampling n values for each parameter to which either a gamma, beta, or normal distribution was assigned built on each input’s mean and standard deviation resulting in n samples. Extracting the 2.5 and 97.5 percentiles allowed the determination of 95 % uncertainty ranges (URs), which were reported with the results. Further details are given in Additional file 1: Section 2.1.
Three univariate sensitivity analyses were performed. First, we set (unrealistically) health services utilization equally to 75 % (close to the highest observed utilization among all conditions, i.e., HIV) across all 20 conditions, all other things being equal (Additional file 1: Section 2.2.1). Second, disease-specific cases, health services utilization, and the size of OOP direct medical costs were varied across the income distribution: (1) disease-specific cases were assumed to be 1.5 times higher within the poorest income quintile than in the richest income quintile; (2) utilization was set to be 2.8 times higher among the richest quintile than in the poorest quintile; (3) OOP direct medical costs were assumed to be 2.9 times higher among the richest than among the poorest (Additional file 1: Section 2.2.2). Third, we used an alternative metric to calculate medical impoverishment, i.e., we estimated the number of cases of catastrophic health costs, counting the number of households whose OOP direct medical costs would exceed 20 % of annual income (Additional file 1: Section 2.2.3). The first sensitivity analysis was meant to address the fact that those individuals who forgo healthcare because of a lack of available services are not always counted in the analysis. The second one intended to capture heterogeneity, including variations with socioeconomic status. The third sensitivity analysis was meant to illustrate the influence of the type of metric chosen for estimating medical impoverishment.
Estimated total number of poverty cases, defined as condition-specific out-of-pocket (OOP) direct medical costs pushing households below the poverty line, for the base case scenario and for two sensitivity analyses ((1) 75 % utilization across all conditions and (2) key inputs including disease-specific cases, utilization, and OOP direct medical costs varying across income), and deaths incurred by each of 20 leading causes of mortality in Ethiopia. The share of poverty cases among all estimated cases and the ranking are also indicated. In brackets are presented the 95 % uncertainty ranges (URs) for the base case
Cause of mortality
Number of poverty cases due to direct OOP medical costs
Number of poverty cases due to direct OOP medical costs, 75 % utilization (1)
Number of poverty cases due to direct OOP medical costs, key inputs varying across income (2)
Number of deaths
Count: 164,100 (95 % UR: 95,000–233,900)
Share: 46.7 % (95 % UR: 32.4–58.1 %)
Ranking: 1 (95 % UR: 1–1)
Share: 30.0 %
Share: 43.2 %
Lower respiratory infections
16.9 % (10.4–26.6 %)
12.8 % (6.8–20.5 %)
3.9 % (2.1–6.8 %)
Ischemic heart disease
3.7 % (2.2–6.2 %)
3.5 % (2.0–6.1 %)
2.8 % (1.7–4.7 %)
Chronic obstructive pulmonary disease
2.1 % (1.2–3.7 %)
1.4 % (0.7–2.5 %)
1.4 % (0.7–2.3 %)
1.2 % (0.6–2.2 %)
1.0 % (0.5–1.8 %)
Preterm birth complications
0.7 % (0.3–1.3 %)
0.5 % (0.3–0.9 %)
0.4 % (0.2–0.8 %)
0.3 % (0.2–0.6 %)
0.3 % (0.2–0.6 %)
0.1 % (0.1–0.2 %)
0.0 % (0.0–0.0 %)
< 100 (0–100)
0.0 % (0.0–0.0 %)
The three top drivers of impoverishment, defined as OOP direct medical costs pushing households below the poverty line, were diarrhea, with approximately 164,000 poverty cases (95 % UR: 95,000–233,900; approximately 47 % (95 % UR: 32–58 %) of all 350,000 cases estimated); lower respiratory infections, with approximately 59,000 cases (35,800–98,400; 17 % (10–27 %) of all cases); and road injuries, with approximately 45,000 cases (24,200–74,800; 13 % (7–20 %) of all cases). The three bottom conditions were breast cancer, with approximately 50 poverty cases (30–100, < 0.1 % of all cases); cervical cancer, with approximately 70 cases (40–120, < 0.1 % of all cases); and cirrhosis with approximately 390 cases (200–600, 0.1 % of all cases) (Table 2). All three bottom conditions had very low utilization rates (2 %).
We observed substantial impoverishment due to OOP direct medical costs for diarrhea and lower respiratory infections (Fig. 1a). The distribution of medical impoverishment by cause became much tighter (road injuries, TB, and ischemic heart disease, then representing 35 %, 11 %, and 10 % of all remaining poverty cases, respectively), when both diarrhea and lower respiratory infections were removed from the analysis. Moreover, we observed that a large number of non-communicable diseases (e.g., ischemic heart disease, asthma, stroke) led to substantial medical impoverishment (Fig. 1b). Some of the important drivers of the medical impoverishment findings seemed to be health services utilization and the number of illness cases, much less so though when, again, diarrhea and lower respiratory infections were removed. On the other hand, OOP direct medical costs seemed less of a driver.
Finally, when we used an alternative metric of cases of catastrophic health costs (Additional file 1: Section 2.2.3), there was a change in the medical impoverishment rankings. Notably, all income quintiles would now be impacted by medical impoverishment (including those previously under the poverty line).
The purpose of this paper was to present a preliminary attempt to systematically estimate medical impoverishment by cause, and the difficulties inherent in making such assessments.
In our case study of Ethiopia, we found that medical impoverishment was tied to illness cases and health services utilization. Cancers presented high OOP costs, but the corresponding population-level medical impoverishment was, in fact, small because countrywide cases of cancer are low, and utilization difficult (Ethiopia has only one cancer treatment center for the whole country, located in a specialized hospital in the capital city of Addis Ababa). However, when we omitted the two leading causes of mortality (lower respiratory infections and diarrhea), we observed little overlap between disease-specific mortality and impoverishment due to OOP direct medical costs.
This approach to medical impoverishment estimation could, with more local data, enable policymakers to take health-related payment criteria into account when designing the architecture of health systems. Financial protection is central to achieving equity and fairness, and a key component of UHC. While economic evaluations have tended to focus on estimating health improvements per dollar spent , newer methods, such as extended cost-effectiveness analysis (ECEA) [11, 20], allow the quantification of financial protection that can be purchased by health policies. A systematic assessment like ours aims at identifying both the proportion of individuals impoverished by OOP direct medical costs and the causes of such impoverishment. This can provide an evidence base for efficient policy and planning. For instance, in 2011 in Ethiopia, the main reason households faced medical impoverishment was expenditure on drugs , which suggested the need for appropriate prepayment mechanisms for accessing healthcare. The government began adopting community-based health insurance and developing social health insurance . A systematic approach quantifying the factors leading to medical impoverishment can point to the causes which social programs should address in order to improve financial protection and equity for all.
Nonetheless, our preliminary attempt has several important limitations. First, we only describe the unidirectional impact of illness on OOP medical impoverishment, and do not include the impact of poverty on health. Second, we deliberately focused on OOP direct medical costs. Yet, there are a number of other factors in impoverishment. Transport costs and indirect costs, including loss of earnings, may contribute significantly to poverty. Illness-related poverty may be correlated with chronic conditions (e.g., epilepsy) among productive adults, leading to more wages lost than acute conditions (e.g., diarrhea). The illness and death of wage earners may impoverish a family over a long time; as this suggests, which individual is impacted in the family (child vs. bread-winner) would matter. However, we were prevented from including these considerations due to the lack of reliable data across conditions. Third, our analysis critically points to the importance of health services utilization data and the inadequacy of current data at the national and global levels. Further utilization data for a large number of conditions is urgently needed. Before new data becomes available, an interim solution would be to estimate utilization for selected groups of conditions (e.g., childhood conditions, major infectious diseases, cancers), depending on incidence, service availability, and recorded patient loads for services in countries. The scarcity of data, including the limited data on utilization but also on OOP costs or private providers (e.g., traditional healers), influenced the choice of our parsimonious modeling approach, relying on secondary inputs and focusing on a limited number of conditions. We restricted our study to leading causes of mortality (and could not include causes of morbidity) as a systematic assessment by cause was solely available for mortality . Yet, by examining high mortality conditions only, our results may be biased against chronic conditions for which payments may be repeated across long time periods. Similarly, for some conditions, we relied on macro-level indicators (e.g., sources of funding for health) and on provider costs to derive OOP costs even though OOP costs are not necessarily based on providers’ costs. We did not include heterogeneity (e.g., geographical variation) in the model due to lack of data. For all these reasons, we preferred a simple framework. We acknowledge that many inputs (e.g., mortality, utilization, OOP costs) present substantial uncertainty; our findings should be interpreted with caution and future work should carefully contextualize our analysis. Fourth, we chose to represent disease-specific impoverishment due to OOP direct medical costs in estimating a headcount of poverty cases in spite of the shortcomings of such threshold-based metrics . Alternative metrics include the estimation of cases of catastrophic health costs , insurance risk premiums , or measures of downside risk arising from uninsured expenditure . We chose the cases of poverty metric for its simplicity, and pursued a sensitivity analysis estimating cases of catastrophic health costs. Further, OOP payments were simply compared to income, not accounting for household borrowing capacity, which could lead to underestimation of coping mechanisms and overestimation of impoverishment .
Finally, our approach may mask the importance of the size of OOP costs and the lack of access to care. Some conditions may lead to large numbers of poverty cases because care is available and hence incurs OOP costs (e.g., road injuries), whereas others may lead to few poverty cases as care is rarely available and thus little in OOP costs can be expected (e.g., cancers). A focus on current medical impoverishment and utilization patterns is not able to distinguish between these two situations. One of our sensitivity analyses is set at 75 % utilization for all conditions in order to acknowledge this limitation. Studying medical impoverishment must be undertaken jointly with the contextual examination of available health services. As greater medical impoverishment may be driven by greater service availability, it would be inadvisable to prioritize services on the basis of greater medical impoverishment only. We emphasize herein the potential financial catastrophes of private financing for health services.
Our intentionally simple approach presents a preliminary attempt to systematically consider the catastrophic consequences of OOP direct medical payments in low- and middle-income countries and the difficulties in such an undertaking. We hope it can be a departure point for substantial empirical and analytical improvements. Our framework represents a stepping stone toward highlighting the importance of the financial protection benefits that could be procured by the scale-up of health interventions. Medical impoverishment findings complemented by the effectiveness of benefits packages and social safety nets can help estimate how much medical impoverishment could be averted by the scale-up of health policies.
We thank two reviewers for useful and constructive comments on earlier versions of the manuscript. Earlier versions of this paper were presented at the Harvard Center for Population and Development Studies, the University of Ottawa School of International Development and Global Studies, the Harvard T.H. Chan School of Public Health, the Federal Ministry of Health of Ethiopia, and the Prince Mahidol Award Conference, and we received valuable comments from seminar participants and others including Richard Cash, Günther Fink, Kjell Arne Johansson, Margaret McConnell, Peter Smith, Mieraf Taddesse Tolla, and Addis Tamire Woldemariam.
This work was funded by the Bill & Melinda Gates Foundation through the Disease Control Priorities Network grant and the Disease Control Priorities-Ethiopia project.
SV initiated and conceptualized the study. SV coordinated the research and performed the analysis with STM and OFN. SV wrote the first draft of the report. All coauthors reviewed the report and provided advice and suggestions. SV and OFN had final responsibility for the decision to submit for publication. All authors read and approved the final manuscript.
The authors declare they have no competing interests.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Xu K, Evans DB, Kawabata K, Zeramdini R, Klavus J, et al. Household catastrophic health expenditure: a multicountry analysis. Lancet. 2003;362:111–7.View ArticlePubMedGoogle Scholar
- Wagstaff A. Measuring financial protection in health. In: Smith PC, Mossialos E, Papanicolas I, Leatherman S, editors. Performance measurement for health system improvement. Cambridge: Cambridge University Press; 2010.Google Scholar
- Kruk ME, Goldmann E, Galea S. Borrowing and selling to pay for health care in low- and middle-income countries. Health Aff. 2009;28(4):1056–66.View ArticleGoogle Scholar
- Wagstaff A, van Doorslaer E. Catastrophe and impoverishment in paying for health care: with applications to Vietnam 1993-1998. Health Econ. 2003;12:921–34.View ArticlePubMedGoogle Scholar
- World Health Organization. World Health Report. Health systems financing, the path to universal coverage. Geneva: WHO; 2010.Google Scholar
- United Nations. Sustainable Development Goals. www.un.org/sustainabledevelopment/sustainable-development-goals/. Accessed 10 Nov 2015.
- World Health Organization. Making fair choices on the path to universal health coverage. Final report of the WHO Consultative Group on Equity and Universal Health Coverage. Geneva: WHO; 2014.Google Scholar
- Xu K, Evans DB, Carrin G, Aguilar-Rivera AM, Musgrove P, et al. Protecting households from catastrophic health spending. Health Aff. 2007;26(4):972–83.View ArticleGoogle Scholar
- Norheim OF, Baltussen R, Johri M, Chisholm D, Nord E, et al. Guidance on priority setting in health care (GPS-Health): the inclusion of equity criteria not captured by cost-effectiveness analysis. Cost Eff Resour Alloc. 2014;12:18.View ArticlePubMedPubMed CentralGoogle Scholar
- World Health Organization. World Health Report 2013 – Research for Universal Health Coverage. Geneva: WHO; 2013.Google Scholar
- Verguet S, Olson ZD, Babigumira JB, Desalegn D, Johansson KA, et al. Health gains and financial risk protection afforded by public financing of selected interventions in Ethiopia: an extended cost-effectiveness analysis. Lancet Glob Health. 2015;3(5):e288–96.View ArticlePubMedGoogle Scholar
- Institute for Health Metrics and Evaluation. Global Burden of Disease Study 2013. http://vizhub.healthdata.org/gbd-compare/. Accessed 25 May 2015.
- Ethiopia Central Statistical Agency and ICF International. 2011 Ethiopia Demographic and Health Survey: Key Findings. Calverton: CSA and ICF International; 2012.Google Scholar
- Global health expenditure database. Geneva: World Health Organization, 2012. www.who.int/nha/country/en/index.html. Accessed 20 Oct 2015.
- World Bank. World Development Indicators. http://data.worldbank.org/country/ethiopia. Accessed 5 Aug 2015.
- Salem ABZ, Mount TD. A convenient descriptive model of income distribution: the gamma density. Econometrica. 1974;42(6):1115–27.View ArticleGoogle Scholar
- Kemp-Benedict E. Income distribution and poverty – Methods for using available data in global analysis. May 17, 2001. http://gdrs.sourceforge.net/docs/PoleStar_TechNote_4.pdf. Accessed 10 Nov 2015Google Scholar
- Ethiopia Ministry of Finance and Economic Development. Ethiopia’s progress towards eradicating poverty: an interim report on poverty analysis study (2010/2011). March, 2012. http://www.mofed.gov.et/documents/20182/25036/Interim+Report+on+2010-11+Poverty+Analysis.pdf/acbfd468-af08-492c-a2e7-7efe0800d6ef. Accessed 20 Mar 2013.
- Jamison DT, Breman JG, Measham AR, Alleyne G, Claeson M, Evans DB, Jha P, Mills A, Musgrove P. Disease Control Priorities in Developing Countries. 2nd ed. Washington, DC: Oxford University Press and the World Bank; 2006.Google Scholar
- Verguet S, Laxminarayan R, Jamison DT. Universal public finance of tuberculosis treatment in India: an extended cost-effectiveness analysis. Health Econ. 2015;24(3):318–32.View ArticlePubMedGoogle Scholar
- Federal Ministry of Health, Ethiopia. Healthcare utilization and burden of household out of pocket expenditure in Ethiopia. Draft document, July 26, 2015. Addis Ababa: Federal Ministry of Health, Ethiopia, 2015.Google Scholar
- Federal Ministry of Health, Ethiopia. Health Sector Transformation Plan HSTP 2015/16 - 2019/20. Addis Ababa: Federal Ministry of Health; 2015.Google Scholar
- Flores G, O’ Donnell O. Catastrophic medical expenditure risk. J Health Econ. 2016;46:1–15.View ArticlePubMedGoogle Scholar
- Flores G, Krishnakumar J, O’ Donnell O, van Doorslaer E. Coping with health-care costs: implications for the measurement of catastrophic expenditures and poverty. Health Econ. 2008;17:1393–412.View ArticlePubMedGoogle Scholar
- Rudan I, Boschi-Pinto C, Biloglav Z, Mulholland K, Campbell H. Epidemiology and etiology of childhood pneumonia. Bull World Health Organ. 2008;86:408–16.View ArticlePubMedPubMed CentralGoogle Scholar
- Rudan I, O’Brien KL, Nair H, Liu L, Theodoratou E, et al. Epidemiology and etiology of childhood pneumonia in 2010: estimates of incidence, morbidity, mortality, underlying risk factors and causative pathogens for 192 countries. J Glob Health. 2013;3(1):010401.View ArticlePubMedPubMed CentralGoogle Scholar
- Fischer Walker CL, Perin J, Aryee MJ, Boschi-Pinto C, Black RE. Diarrhea incidence in low- and middle-income countries in 1990 and 2010: a systematic review. BMC Public Health. 2012;12:220.View ArticlePubMedPubMed CentralGoogle Scholar
- Liu L, Johnson HL, Cousens S, Perin J, Scott S, et al. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012;379:2151–61.View ArticlePubMedGoogle Scholar
- Lamberti LM, Fischer Walker CL, Black RE. Systematic review of diarrhea duration and severity on children and adults in low- and middle-income countries. BMC Public Health. 2012;12:276.View ArticlePubMedPubMed CentralGoogle Scholar
- Stack ML, Ozawa S, Bishai DM, Mirelman A, Tam Y, et al. Estimated economic benefits during the ‘Decade of Vaccines’ include treatment savings, gains in labor productivity. Health Aff. 2011;30(6):1021–8.View ArticleGoogle Scholar
- World Health Organization. World malaria report 2014. Geneva: WHO; 2014.Google Scholar
- Jima D, Wondabeku M, Alemu A, Teferra A, Awel N, et al. Analysis of malaria surveillance data in Ethiopia: what can be learned from the Integrated Disease Surveillance and Response System? Malar J. 2012;11:330.View ArticlePubMedPubMed CentralGoogle Scholar
- Deressa W, Hailemariam D, Ali A. Economic costs of epidemic malaria to households in rural Ethiopia. Trop Med Int Health. 2007;12(10):1148–56.View ArticlePubMedGoogle Scholar
- World Health Organization. Global Tuberculosis Report 2014. Geneva: WHO; 2014.Google Scholar
- Datiko DG, Lindjørn B. Cost and cost-effectiveness of treating tuberculosis by health extension workers in Ethiopia: an ancillary cost-effectiveness analysis of community randomized trial. PLoS One. 2010;5(2):e9158.View ArticlePubMedPubMed CentralGoogle Scholar
- Hollander M, Koudstaal PJ, Bots ML, Grobbee DE, Hofman A. Incidence, risk, and case fatality of first ever stroke in the elderly population. The Rotterdam Study. J Neurol Neurosurg Psychiatry. 2003;74:317–21.View ArticlePubMedPubMed CentralGoogle Scholar
- Mudzi W, Stewart A, Musenge E. Case fatality of patients with stroke over a 12-month period post stroke. S Afr Med J. 2012;102(9):765–7.View ArticlePubMedGoogle Scholar
- Maredza M, Bertram MY, Tollman SM. Disease burden of stroke in rural South Africa: an estimate of incidence, mortality, and disability adjusted life years. BMC Neurol. 2015;15:54.View ArticlePubMedPubMed CentralGoogle Scholar
- Zenebe G, Alemayehu M, Asmera J. Characteristics and outcomes of stroke at Tikur Anbessa teaching hospital, Ethiopia. Ethiop Med J. 2005;43(4):251–9.PubMedGoogle Scholar
- Gibbons L, Belizan JM, Lauer JA, Betrán AP, Merialdi M, Althabe F. The global numbers and costs of additionally needed and unnecessary caesarean sections performed per year: overuse as a barrier to universal coverage. World Health Report (2010). Background Paper, 30. http://www.who.int/healthsystems/topics/financing/healthreport/30Csectioncosts.pdf. Accessed 9 Mar 2015.
- Central Statistical Agency [Ethiopia]. Ethiopia Mini Demographic and Health Survey 2014. Addis Ababa: CSA; 2014.Google Scholar
- Adam T, Lim SS, Mehta S, Bhutta ZA, Fogstad H, et al. Cost effectiveness analysis of strategies for maternal and neonatal health in developing countries. BMJ. 2005;331:1107.View ArticlePubMedPubMed CentralGoogle Scholar
- Beck S, Wojdyla D, Say L, Betran AP, Merialdi M, et al. The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity. Bull World Health Organ. 2010;88:31–8.View ArticlePubMedGoogle Scholar
- United Nations Population Division. World Population Prospects: the 2010 Revision. New York: United Nations; 2011.Google Scholar
- UNAIDS. Global report: UNAIDS report on the global AIDS epidemic 2013. Geneva: UNAIDS; 2013.Google Scholar
- Bikilla AD, Jerene D, Robberstad B, Lindjørn B. Cost-effectiveness of anti-retroviral therapy at a district hospital in southern Ethiopia. Cost Eff Resour Alloc. 2009;7:13.View ArticlePubMedPubMed CentralGoogle Scholar
- Tagar E, Sundaram M, Condliffe K, Matatiyo B, Chimbwandira F, et al. Multi-Country Analysis of Treatment Costs for HIV/AIDS (MATCH): Facility-Level ART Unit Cost Analysis in Ethiopia, Malawi, Rwanda, South Africa and Zambia. PLoS One. 2014;9(11):e108304.View ArticlePubMedPubMed CentralGoogle Scholar
- Rosen S, Long L. How much does it cost to provide antiretroviral therapy for HIV/AIDS in Africa? Health and Development Discussion Paper No.9. Boston: Center for International Health and Development Boston University School of Public Health; 2006.Google Scholar
- Kifle YA, Nigatu TH. Cost-effectiveness analysis of clinical specialist outreach as compared to referral system in Ethiopia: an economic evaluation. Cost Eff Resour Alloc. 2010;8:13.View ArticlePubMedPubMed CentralGoogle Scholar
- Bhalla K, Harrison J, Shahraz S, Abraham JP, Bartels D, et al. Burden of Road Injuries in Sub-Saharan Africa. Boston: Department of Global Health and Population, Harvard School of Public Health; 2013.Google Scholar
- Ramakrishnan M, Ulland AJ, Steinhardt LC, Moïsi JC, Were F, Levine OS. Sequelae due to bacterial meningitis among African children: a systematic literature review. BMC Med. 2009;7:47.View ArticlePubMedPubMed CentralGoogle Scholar
- Eryd SA, Smith G, Melander O, Hedbad B, Engström G. Incidence of coronary events and case fatality rate in relation to blood lymphocyte and neutrophil counts. Arterioscler Thromb Vasc Biol. 2012;32(2):533–9.View ArticleGoogle Scholar
- Lang T, Ducimetière P, Arveiler D, Amouyel P, Cambou J-P. Incidence, case fatality, risk factors of acute coronary heart disease and occupational categories in men aged 30-59 in France. Int J Epidemiol. 1997;26(1):47–57.View ArticlePubMedGoogle Scholar
- Wolfson LJ, Grais RF, Luquero FJ, Birmingham ME, Strebel PM. Estimates of measles case fatality ratios: comprehensive review of community-based studies. Int J Epidemiol. 2009;38:192–205.View ArticlePubMedGoogle Scholar
- Talley NJ, Locke R, Saito YA. GI Epidemiology. Oxford: Blackwell Publishing; 2007.View ArticleGoogle Scholar
- Présiozi M-P, Yam A, Wassilak SGF, Chabirand L, Simaga A, et al. Epidemiology of pertussis in a west African community before and after introduction of a widespread vaccination program. Am J Epidemiol. 2002;155:891–6.View ArticleGoogle Scholar
- Gizaw M, Harries AD, Ade S, Tayler-Smith K, Ali E, et al. Diabetes mellitus in Addis Ababa, Ethiopia: admissions, complications and outcomes in a large referral hospital. Int Union Tuberc Lung Dis. 2015;5(1):74–8.Google Scholar
- Misganaw A, Hailemariam D, Ali A, Araya T. Epidemiology of major non-communicable diseases in Ethiopia: a systematic review. J Health Popul Nutr. 2014;32(1):1–13.PubMedPubMed CentralGoogle Scholar
- Ba-Diop A, Marin B, Druet-Cabanac, Nagoungou E, Newton CR, Preux P-M. Epidemiology, causes, and treatment of epilepsy in sub-Saharan Africa. Lancet Neurol. 2014;13:1029–44.View ArticlePubMedGoogle Scholar
- Bjerkreim Strand K, Chisholm D, Fekadu A, Johansson KA. Scaling-up essential neuropsychiatric services in Ethiopia: a cost-effectiveness analysis. Health Policy Plan. 2016;31(4):504–13. doi:https://doi.org/10.1093/heapol/czv093.View ArticleGoogle Scholar
- GLOBOCAN. http://globocan.iarc.fr/Pages/fact_sheets_population.aspx. Accessed 6 Aug 2015.
- Hailu A, Haile MD. Patient side cost and its predictors for cervical cancer in Ethiopia: a cross sectional hospital based study. BMC Cancer. 2013;13:69.View ArticlePubMedPubMed CentralGoogle Scholar
- Woldeamanuel YW, Girma B, Teklu AM. Cancer in Ethiopia. Lancet. 2013;14:289–90.View ArticlePubMedGoogle Scholar
- Groot MT, Baltussen R, Uyl-de Groot CA, Anderson BO, Hortobágyi GN. Costs and health effects of breast cancer interventions in epidemiologically different regions of Africa, North America, and Asia. Breast J. 2006;12 Suppl 1:S81–90.View ArticlePubMedGoogle Scholar
- To T, Stanojevic S, Moores G, Gershon AS, Bateman ED, et al. Global asthma prevalence in adults: findings from the cross-sectional world health survey. BMC Public Health. 2012;12:204.View ArticlePubMedPubMed CentralGoogle Scholar
- Kirigia JM, Sambo HB, Sambo LG, Barry SP. Economic burden of diabetes mellitus in the WHO African region. BMC Int Health Hum Rights. 2009;9:6.View ArticlePubMedPubMed CentralGoogle Scholar
- Lawn JE, Shibuya K, Stein C. No cry at birth: global estimates of intrapartum stillbirths and intrapartum-related neonatal deaths. Bull World Health Organ. 2005;83:409–17.PubMedPubMed CentralGoogle Scholar