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  1. Obesity in pregnancy and related early-life factors place the offspring at the highest risk of being overweight. Despite convincing evidence on these associations, there is an unmet public health need to ident...

    Authors: Delphina Gomes, Lien Le, Sarah Perschbacher, Nikolaus A. Haas, Heinrich Netz, Uwe Hasbargen, Maria Delius, Kristin Lange, Uta Nennstiel, Adelbert A. Roscher, Ulrich Mansmann and Regina Ensenauer
    Citation: BMC Medicine 2022 20:156
  2. Reliable assessment of glycemia is central to the management of diabetes. The kidneys play a vital role in maintaining glucose homeostasis through glucose filtration, reabsorption, consumption, and generation....

    Authors: Mohamed Hassanein and Tariq Shafi
    Citation: BMC Medicine 2022 20:117
  3. Organ-specific metastatic context has not been incorporated into the clinical practice of guiding programmed death-(ligand) 1 [PD-(L)1] blockade, due to a lack of understanding of its predictive versus prognos...

    Authors: Si-Cong Ma, Xue Bai, Xue-Jun Guo, Li Liu, Lu-Shan Xiao, Yan Lin, Jia-Le Tan, Xiao-Ting Cai, Yu-Xiang Wen, Hu Ma, Q. John Fu, Meng-Xin Leng, Yan-Pei Zhang, Li-Li Long, Ze-Qin Guo, De-Hua Wu…
    Citation: BMC Medicine 2022 20:120
  4. Previous studies have reported associations between attention-deficit/hyperactivity disorder (ADHD) and lower socioeconomic status and intelligence. We aimed to evaluate the causal directions and strengths for...

    Authors: Madeleine Michaëlsson, Shuai Yuan, Håkan Melhus, John A. Baron, Liisa Byberg, Susanna C. Larsson and Karl Michaëlsson
    Citation: BMC Medicine 2022 20:106
  5. Preterm birth (PTB) is a syndrome resulting from a complex list of underlying causes and factors, and whether these risk factors differ in the context of prior PTB history is less understood. The aim of this s...

    Authors: Aline S. Rocha, Rita de Cássia Ribeiro-Silva, Rosemeire L. Fiaccone, Enny S. Paixao, Ila R. Falcão, Flavia Jôse O. Alves, Natanael J. Silva, Naiá Ortelan, Laura C. Rodrigues, Maria Yury Ichihara, Marcia F. de Almeida and Mauricio L. Barreto
    Citation: BMC Medicine 2022 20:111
  6. Dengue shock syndrome (DSS) is one of the major clinical phenotypes of severe dengue. It is defined by significant plasma leak, leading to intravascular volume depletion and eventually cardiovascular collapse....

    Authors: Huynh Trung Trieu, Lam Phung Khanh, Damien Keng Yen Ming, Chanh Ho Quang, Tu Qui Phan, Vinh Chau Nguyen Van, Ertan Deniz, Jane Mulligan, Bridget Ann Wills, Steven Moulton and Sophie Yacoub
    Citation: BMC Medicine 2022 20:109
  7. In March 2020, the UK implemented the Coronavirus Job Retention Scheme (furlough) to minimise job losses. Our aim was to investigate associations between furlough and diet, physical activity, and sleep during ...

    Authors: Bożena Wielgoszewska, Jane Maddock, Michael J. Green, Giorgio Di Gessa, Sam Parsons, Gareth J. Griffith, Jazz Croft, Anna J. Stevenson, Charlotte Booth, Richard J. Silverwood, David Bann, Praveetha Patalay, Alun D. Hughes, Nishi Chaturvedi, Laura D. Howe, Emla Fitzsimons…
    Citation: BMC Medicine 2022 20:147

    The Correction to this article has been published in BMC Medicine 2022 20:285

  8. Adding anti-angiogenics to neoadjuvant chemotherapy for localized gastric cancer is recognized as a promising strategy, but its clinical value remains to be defined.

    Authors: Zhaoqing Tang, Yan Wang, Yiyi Yu, Yuehong Cui, Liang Liang, Chen Xu, Zhenbin Shen, Kuntang Shen, Xuefei Wang, Tianshu Liu and Yihong Sun
    Citation: BMC Medicine 2022 20:107
  9. More doses of CoronaVac have been administered worldwide than any other COVID-19 vaccine. However, the effectiveness of COVID-19 inactivated vaccines in pregnant women is still unknown. We estimated the vaccin...

    Authors: Enny S. Paixao, Kerry L. M. Wong, Flavia Jôse Oliveira Alves, Vinicius de Araújo Oliveira, Thiago Cerqueira-Silva, Juracy Bertoldo Júnior, Tales Mota Machado, Elzo Pereira Pinto Junior, Viviane S. Boaventura, Gerson O. Penna, Guilherme Loureiro Werneck, Laura C. Rodrigues, Neil Pearce, Mauricio L. Barreto and Manoel Barral-Netto
    Citation: BMC Medicine 2022 20:146
  10. Selinexor 80 mg combined with low-dose dexamethasone (Sd) demonstrated significant clinical benefit in patients with relapsed/refractory multiple myeloma (RRMM) who had disease refractory to a proteasome inhib...

    Authors: Lugui Qiu, Zhongjun Xia, Chengcheng Fu, Wenming Chen, Chunkang Chang, Baijun Fang, Gang An, Yongqiang Wei, Zhen Cai, Sujun Gao, Jianyu Weng, Lijuan Chen, Hongmei Jing, Fei Li, Zhuogang Liu, Xiequn Chen…
    Citation: BMC Medicine 2022 20:108
  11. Dietary phytoestrogens have been suggested to influence puberty timing, a critical stage for well-being in adulthood. We hypothesized that childhood soy intake might prospectively influence puberty timing and ...

    Authors: Jingyuan Xiong, Yujie Xu, Xueting Liu, Xiaoyu Wang, Shufang Shan, M. James C. Crabbe, Li Zhao, He Fang and Guo Cheng
    Citation: BMC Medicine 2022 20:145
  12. Hundreds of millions of doses of coronavirus disease 2019 (COVID-19) vaccines have been administered globally, but progress on vaccination varies considerably between countries. We aimed to provide an overall ...

    Authors: Zhiyuan Chen, Wen Zheng, Qianhui Wu, Xinghui Chen, Cheng Peng, Yuyang Tian, Ruijia Sun, Jiayi Dong, Minghan Wang, Xiaoyu Zhou, Zeyao Zhao, Guangjie Zhong, Xuemei Yan, Nuolan Liu, Feiran Hao, Sihong Zhao…
    Citation: BMC Medicine 2022 20:130
  13. Limited data exist regarding the potential impact of assisted reproductive technology (ART) on cardiac remodeling. In particular, whether different ART techniques are related to different cardiac alterations r...

    Authors: Wenjing Bi, Yangjie Xiao, Xin Wang, Li Cui, Guang Song, Zeyu Yang, Ying Zhang and Weidong Ren
    Citation: BMC Medicine 2022 20:104
  14. Dietary interventions targeting the gut microbiota have been proposed as innovative strategies to improve obesity-associated metabolic disorders. Increasing physical activity (PA) is considered as a key behavi...

    Authors: Julie Rodriguez, Audrey M. Neyrinck, Maxime Van Kerckhoven, Marco A. Gianfrancesco, Edith Renguet, Luc Bertrand, Patrice D. Cani, Nicolas Lanthier, Miriam Cnop, Nicolas Paquot, Jean-Paul Thissen, Laure B. Bindels and Nathalie M. Delzenne
    Citation: BMC Medicine 2022 20:110
  15. SARS-CoV-2 infection portends a broad range of outcomes, from a majority of asymptomatic cases to a lethal disease. Robust correlates of severe COVID-19 include old age, male sex, poverty, and co-morbidities s...

    Authors: Emily Toscano-Guerra, Mónica Martínez-Gallo, Iria Arrese-Muñoz, Anna Giné, Noelia Díaz-Troyano, Pablo Gabriel-Medina, Mar Riveiro-Barciela, Moisés Labrador-Horrillo, Fernando Martinez-Valle, Adrián Sánchez Montalvá, Manuel Hernández-González, Ricardo Pujol Borrell, Francisco Rodríguez-Frias, Roser Ferrer, Timothy M. Thomson and Rosanna Paciucci
    Citation: BMC Medicine 2022 20:129
  16. Data on the relations between kidney function abnormalities and stroke in type 2 diabetes are limited. We evaluated the associations of kidney function abnormalities and chronic kidney disease (CKD) stages wit...

    Authors: Arnaud D. Kaze, Bernard G. Jaar, Gregg C. Fonarow and Justin B. Echouffo-Tcheugui
    Citation: BMC Medicine 2022 20:127
  17. Binding and neutralising anti-Spike antibodies play a key role in immune defence against SARS-CoV-2 infection. Since it is known that antibodies wane with time and new immune-evasive variants are emerging, we ...

    Authors: Marah G. Chibwana, Thandeka Moyo-Gwete, Gaurav Kwatra, Jonathan Mandolo, Tandile Hermanaus, Thopisang Motlou, Nonkululeko Mzindle, Frances Ayres, Mphatso Chaponda, Godwin Tembo, Percy Mwenechanya, Ndaona Mitole, Chisomo Jassi, Raphael Kamng’ona, Louise Afran, David Mzinza…
    Citation: BMC Medicine 2022 20:128
  18. Thymidine phosphorylase (TP), encoded by the TYMP gene, is a cytosolic enzyme essential for the nucleotide salvage pathway. TP catalyzes the phosphorylation of the deoxyribonucleosides, thymidine and 2′-deoxyurid...

    Authors: Jérémie Gautheron, Lara Lima, Baris Akinci, Jamila Zammouri, Martine Auclair, Sema Kalkan Ucar, Samim Ozen, Canan Altay, Bridget E. Bax, Ivan Nemazanyy, Véronique Lenoir, Carina Prip-Buus, Cécile Acquaviva-Bourdain, Olivier Lascols, Bruno Fève, Corinne Vigouroux…
    Citation: BMC Medicine 2022 20:95
  19. Both changes in circulating lipids represented by a validated poor prognostic 3-lipid signature (3LS) and somatic tumour genetic aberrations are individually associated with worse clinical outcomes in men with...

    Authors: Blossom Mak, Hui-Ming Lin, Edmond M. Kwan, Heidi Fettke, Ben Tran, Ian D. Davis, Kate Mahon, Martin R. Stockler, Karen Briscoe, Gavin Marx, Alison Zhang, Megan Crumbaker, Winston Tan, Kevin Huynh, Thomas G. Meikle, Natalie A. Mellett…
    Citation: BMC Medicine 2022 20:112
  20. Women’s reproductive factors include their age at menarche and menopause, the age at which they start and stop having children and the number of children they have. Studies that have linked these factors with ...

    Authors: Claire Prince, Gemma C. Sharp, Laura D. Howe, Abigail Fraser and Rebecca C. Richmond
    Citation: BMC Medicine 2022 20:103
  21. High variability in the definition and interpretation of organized cancer screening needs to be addressed systematically. Moreover, the relevance of the current practice of categorizing screening programmes di...

    Authors: Li Zhang, André L. Carvalho, Isabel Mosquera, Tianmeng Wen, Eric Lucas, Catherine Sauvaget, Richard Muwonge, Marc Arbyn, Elisabete Weiderpass and Partha Basu
    Citation: BMC Medicine 2022 20:101
  22. The effect of ezetimibe, Niemann-Pick C1-like 1 inhibitor, on liver fat is not clearly elucidated. Our primary objective was to evaluate the efficacy of ezetimibe plus rosuvastatin versus rosuvastatin monother...

    Authors: Yongin Cho, Hyungjin Rhee, Young-eun Kim, Minyoung Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Jin-Young Choi and Yong-ho Lee
    Citation: BMC Medicine 2022 20:93
  23. Eliminating Plasmodium vivax will require targeting the hidden liver-stage reservoir of hypnozoites. This necessitates new interventions balancing the benefit of reducing vivax transmission against the risk of ov...

    Authors: Thomas Obadia, Narimane Nekkab, Leanne J. Robinson, Chris Drakeley, Ivo Mueller and Michael T. White
    Citation: BMC Medicine 2022 20:98
  24. Safety after the second dose of the SARS-CoV-2 vaccine remains to be elucidated, especially among individuals reporting adverse events after their first dose. This study aims to evaluate the impact of a delaye...

    Authors: Carlos King Ho Wong, Xi Xiong, Kristy Tsz Kwan Lau, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Xue Li, Esther Wai Yin Chan, Eric Yuk Fai Wan, Ivan Chi Ho Au, Benjamin John Cowling, Cheuk Kwong Lee and Ian Chi Kei Wong
    Citation: BMC Medicine 2022 20:119
  25. HER2-low breast cancer (BC) is currently an area of active interest. This study evaluated the impact of low expression of HER2 on survival outcomes in HER2-negative non-metastatic breast cancer (BC).

    Authors: Ryan Shea Ying Cong Tan, Whee Sze Ong, Kyung-Hun Lee, Abner Herbert Lim, Seri Park, Yeon Hee Park, Ching-Hung Lin, Yen-Shen Lu, Makiko Ono, Takayuki Ueno, Yoichi Naito, Tatsuya Onishi, Geok-Hoon Lim, Su-Ming Tan, Han-Byoel Lee, Han Suk Ryu…
    Citation: BMC Medicine 2022 20:105
  26. Faecal immunochemical tests (FITs) are used to triage primary care patients with symptoms that could be caused by colorectal cancer for referral to colonoscopy. The aim of this study was to determine whether c...

    Authors: Diana R. Withrow, Brian Shine, Jason Oke, Andres Tamm, Tim James, Eva Morris, Jim Davies, Steve Harris, James E. East and Brian D. Nicholson
    Citation: BMC Medicine 2022 20:116
  27. Fall risk screening using multiple methods was strongly advised as the initial step for preventing fall. Currently, there is only one such tool which was proposed by the U.S. Centers for Disease Control and Pr...

    Authors: Sriprapa Loonlawong, Weerawat Limroongreungrat, Thanapoom Rattananupong, Kamonrat Kittipimpanon, Wanvisa Saisanan Na Ayudhaya and Wiroj Jiamjarasrangsi
    Citation: BMC Medicine 2022 20:78
  28. Targeted therapy is the key for improving overall survival while decreasing the undesirable adverse effects of cancer treatment. Patients who received matched targeted therapies showed dramatically improved ov...

    Authors: Zhijun Zhou and Min Li
    Citation: BMC Medicine 2022 20:90
  29. Subnational heterogeneity in immunity to measles can create pockets of susceptibility and result in long-lasting outbreaks despite high levels of national vaccine coverage. The elimination status defined by th...

    Authors: Alexis Robert, Adam J. Kucharski and Sebastian Funk
    Citation: BMC Medicine 2022 20:77
  30. Dynamic modeling is commonly used to evaluate direct and indirect effects of interventions on infectious disease incidence. The risk of secondary outcomes (e.g., death) attributable to infection may depend on ...

    Authors: Allison Portnoy, Yuli Lily Hsieh, Kaja Abbas, Petra Klepac, Heather Santos, Logan Brenzel, Mark Jit and Matthew Ferrari
    Citation: BMC Medicine 2022 20:113
  31. Plasmodium vivax (P. vivax) is the dominant Plasmodium spp. causing the disease malaria in low-transmission regions outside of Africa. These regions often feature high proportions of asymptomatic patients with su...

    Authors: Zoe Shih-Jung Liu, Jetsumon Sattabongkot, Michael White, Sadudee Chotirat, Chalermpon Kumpitak, Eizo Takashima, Matthias Harbers, Wai-Hong Tham, Julie Healer, Chetan E. Chitnis, Takafumi Tsuboi, Ivo Mueller and Rhea J. Longley
    Citation: BMC Medicine 2022 20:89
  32. Differences in definitions and methodological approaches have hindered comparison and synthesis of economic evaluation results across multiple health domains, including immunization. At the request of the Worl...

    Authors: Ann Levin, Laura Boonstoppel, Logan Brenzel, Ulla Griffiths, Raymond Hutubessy, Mark Jit, Vittal Mogasale, Sarah Pallas, Stephen Resch, Christian Suharlim and Karene Hoi Ting Yeung
    Citation: BMC Medicine 2022 20:88
  33. Antagonizing the androgen-receptor (AR) pathway is an effective treatment strategy for patients with metastatic castration-resistant prostate cancer (CRPC). Here, we report the results of a first-in-human phas...

    Authors: Xiaojian Qin, Dongmei Ji, Weijie Gu, Weiqing Han, Hong Luo, Chuanjun Du, Qing Zou, Zhongquan Sun, Chaohong He, Shaoxing Zhu, Tie Chong, Xin Yao, Ben Wan, Xinfeng Yang, Aobing Bai, Chunlei Jin…
    Citation: BMC Medicine 2022 20:84
  34. The COVID-19 pandemic is caused by the betacoronavirus SARS-CoV-2. In November 2021, the Omicron variant was discovered and immediately classified as a variant of concern (VOC), since it shows substantially mo...

    Authors: Maren Schubert, Federico Bertoglio, Stephan Steinke, Philip Alexander Heine, Mario Alberto Ynga-Durand, Henrike Maass, Josè Camilla Sammartino, Irene Cassaniti, Fanglei Zuo, Likun Du, Janin Korn, Marko Milošević, Esther Veronika Wenzel, Fran Krstanović, Saskia Polten, Marina Pribanić-Matešić…
    Citation: BMC Medicine 2022 20:102
  35. The shortage of available organs for life-saving transplants persists worldwide. While a majority support donating their organs or tissue when they die, many have not registered their wish to do so. When regis...

    Authors: Alvin Ho-ting Li, Amit X. Garg, Jeremy M. Grimshaw, Versha Prakash, Alexie J. Dunnett, Stephanie N. Dixon, Monica Taljaard, Joanna Mitchell, Kyla L. Naylor, Cathy Faulds, Rachel Bevan, Leah Getchell, Greg Knoll, S. Joseph Kim, Jessica Sontrop, Allison Tong…
    Citation: BMC Medicine 2022 20:75
  36. Studies have suggested incremental short-term adverse events (AE) after repeated vaccination. In this report, we assessed occurrence and risk factors for short-term AEs following repeated SARS-CoV-2 vaccinatio...

    Authors: Luuk Wieske, Laura Y. L. Kummer, Koos P. J. van Dam, Eileen W. Stalman, Anneke J. van der Kooi, Joost Raaphorst, Mark Löwenberg, R. Bart Takkenberg, Adriaan G. Volkers, Geert R. A. M. D’Haens, Sander W. Tas, Phyllis I. Spuls, Marcel W. Bekkenk, Annelie H. Musters, Nicoline F. Post, Angela L. Bosma…
    Citation: BMC Medicine 2022 20:100
  37. Accurate and non-invasive diagnosis of pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP) can avoid unnecessary puncture and surgery. This study aimed to develop a deep learning radiomics (D...

    Authors: Tong Tong, Jionghui Gu, Dong Xu, Ling Song, Qiyu Zhao, Fang Cheng, Zhiqiang Yuan, Shuyuan Tian, Xin Yang, Jie Tian, Kun Wang and Tian’an Jiang
    Citation: BMC Medicine 2022 20:74
  38. Authors: Chathika K. Weerasuriya, Rebecca C. Harris, C. Finn McQuaid, Fiammetta Bozzani, Yunzhou Ruan, Renzhong Li, Tao Li, Kirankumar Rade, Raghuram Rao, Ann M. Ginsberg, Gabriela B. Gomez and Richard G. White
    Citation: BMC Medicine 2022 20:99

    The original article was published in BMC Medicine 2021 19:60

  39. Type 2 diabetes is one of the leading causes of chronic kidney failure, which increases globally and represents a significant threat to public health. People from the Middle East represent one of the largest i...

    Authors: Siham A. Mohamed, Juan Fernadez-Tajes, Paul W. Franks and Louise Bennet
    Citation: BMC Medicine 2022 20:76
  40. The combined health impact of physical activity (PA) and air pollution on chronic obstructive pulmonary disease (COPD) remains unclear. We investigated the joint effects of habitual PA and long-term fine parti...

    Authors: Lan Chen, Miao Cai, Haitao Li, Xiaojie Wang, Fei Tian, Yinglin Wu, Zilong Zhang and Hualiang Lin
    Citation: BMC Medicine 2022 20:70
  41. The success of antithrombotic therapies is assessed based on thrombotic and bleeding events. Simultaneously assessing both kinds of events might be challenging, and recurrent bleeding events are often ignored....

    Authors: Kunihiko Matsui, Satoshi Yasuda, Koichi Kaikita, Masaharu Akao, Junya Ako, Tetsuya Matoba, Masato Nakamura, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama and Hisao Ogawa
    Citation: BMC Medicine 2022 20:69
  42. The associations of cancer with types of diets, including vegetarian, fish, and poultry-containing diets, remain unclear. The aim of this study was, therefore, to investigate the association of type of diet wi...

    Authors: Solange Parra-Soto, Danay Ahumada, Fanny Petermann-Rocha, Jirapitcha Boonpoor, Jose Lara Gallegos, Jana Anderson, Linda Sharp, Fiona C. Malcomson, Katherine M. Livingstone, John C. Mathers, Jill P. Pell, Frederick K. Ho and Carlos Celis-Morales
    Citation: BMC Medicine 2022 20:79

    The Commentary to this article has been published in BMC Medicine 2022 20:81

    The Research article to this article has been published in BMC Medicine 2022 20:73