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  1. To evaluate the neurological alterations induced by Omicron infection, to compare brain changes in chronic insomnia with those in exacerbated chronic insomnia in Omicron patients, and to examine individuals wi...

    Authors: Yanyao Du, Cong Li, Wei Zhao, Jinyue Li, Linlin Zhao, Huili Guo, Yingjia Jiang, Weiyin Vivian Liu, Song Zeng, Huiting Zhang, Hu Guo, Xuan Ouyang and Jun Liu
    Citation: BMC Medicine 2024 22:271
    Content type: Research Published on:

  2. Previous studies, including Mendelian randomization (MR), have demonstrated type 2 diabetes (T2D) and glycemic traits are associated with increased risk of metabolic dysfunction-associated steatotic liver dise...

    Authors: Ying Liang, Shan Luo, Steven Bell, Jacky Man Yuen Mo, Baoting He, Yangzhong Zhou, Xiaoyin Bai and Shiu Lun Au Yeung
    Citation: BMC Medicine 2024 22:270
    Content type: Research article Published on:

  3. Interest in modifiable risk factors (MRFs) for dementia is high, given the personal, social, and economic impact of the disorder, especially in ageing societies such as the United Kingdom. Exploring the popula...

    Authors: Shanquan Chen, Benjamin R. Underwood, Rudolf N. Cardinal, Xi Chen, Shu Chen, Jay Amin, Huajie Jin, Jing Huang, Christoph Mueller, Lijing L. Yan, Carol Brayne and Hannah Kuper
    Citation: BMC Medicine 2024 22:268
    Content type: Research article Published on:

  4. Evidence from observational studies indicates that lung cancer screening (LCS) guidelines with high rates of lung cancer (LC) underdiagnosis, and although current screening guidelines have been updated and eli...

    Authors: Yanyan Tang, Lina Zhou, Fei Wang, Yao Huang, Jianwei Wang, Shijun Zhao, Linlin Qi, Li Liu, Min Liang, Donghui Hou, Zhijian Xu, Kai Zhang, Wei Tang and Ning Wu
    Citation: BMC Medicine 2024 22:267
    Content type: Research article Published on:

  5. People with different types of dementia may have distinct symptoms and experiences that affect their quality of life. This study investigated whether quality of life varied across types of dementia and over time.

    Authors: Anthony Martyr, Laura D. Gamble, Anna Hunt, Catherine Quinn, Robin G. Morris, Catherine Henderson, Louise Allan, Carol Opdebeeck, Catherine Charlwood, Roy W. Jones, Claire Pentecost, Michael D. Kopelman, Jeanette M. Thom, Fiona E. Matthews and Linda Clare
    Citation: BMC Medicine 2024 22:265
    Content type: Research article Published on:

  6. Ureteral cancer is a rare cancer. This study aimed to provide an up-to-date and comprehensive analysis on the global trends of ureteral cancer incidence and its association with lifestyle and metabolic risk fa...

    Authors: Junjie Huang, Wing Sze Pang, Yat Ching Fung, Fung Yu Mak, Sze Chai Chan, Xianjing Liu, Lin Zhang, Don Eliseo Lucero-Prisno III, Wanghong Xu, Zhi-Jie Zheng, Marco Moschini, Benjamin Pradere, Francesco Soria, Dmitry Enikeev, Morgan Roupret, Shahrokh Shariat…
    Citation: BMC Medicine 2024 22:264
    Content type: Research article Published on:

  7. To combat coronavirus disease 2019 (COVID-19), booster vaccination strategies are important. However, the optimal administration of booster vaccine platforms remains unclear. Herein, we aimed to assess the ben...

    Authors: Mark Aninakwah Asante, Martin Ekholm Michelsen, Mithuna Mille Balakumar, Buddheera Kumburegama, Amin Sharifan, Allan Randrup Thomsen, Steven Kwasi Korang, Christian Gluud and Sonia Menon
    Citation: BMC Medicine 2024 22:263
    Content type: Research article Published on:

  9. To assess the largely undetermined separate and joint effects of sleep and liver function biomarkers on liver cancer.

    Authors: Jiahao Song, Lieyang Fan, Da Shi, Xuefeng Lai, Hao Wang, Wei Liu, Linling Yu, Ruyi Liang, Yongfang Zhang, Shuhui Wan, Yueru Yang and Bin Wang
    Citation: BMC Medicine 2024 22:261
    Content type: Research article Published on:

  10. The cancer experienced in adolescent and young adult (AYA) could disturb developmental changes and long-term life. The current AYA guidelines and research for survivorship were developed and reported according...

    Authors: Sooyeon Kim, Dong Wook Shin, Su-Min Jeong, Danbee Kang and Juhee Cho
    Citation: BMC Medicine 2024 22:260
    Content type: Research article Published on:

  11. IMCY-0098, a synthetic peptide developed to halt disease progression via elimination of key immune cells in the autoimmune cascade, has shown a promising safety profile for the treatment of type 1 diabetes (T1...

    Authors: Jean Van Rampelbergh, Peter Achenbach, Richard David Leslie, Martin Kindermans, Frédéric Parmentier, Vincent Carlier, Nicolas Bovy, Luc Vanderelst, Marcelle Van Mechelen, Pierre Vandepapelière and Christian Boitard
    Citation: BMC Medicine 2024 22:259
    Content type: Research article Published on:

  12. The 2018/2023 ESC/ESH Guidelines underlined a gap how baseline cardiovascular disease (CVD) risk predicted blood pressure (BP) lowering benefits. Further, 2017 ACC/AHA Guideline and 2021 WHO Guideline recommen...

    Authors: Guozhe Sun, Chang Wang, Ning Ye, Chuning Shi, Nanxiang Ouyang, Lixia Qiao, Guangxiao Li, Linlin Zhang, Yao Yu, Zhi Li, Ying Zhou, Zihan Chen, Shu Zhang, Pengyu Zhang, Danxi Geng, Wei Miao…
    Citation: BMC Medicine 2024 22:258
    Content type: Research article Published on:

  14. The relationship between variation in serum uric acid (SUA) levels and brain health is largely unknown. This study aimed to examine the associations of long-term variability in SUA levels with neuroimaging met...

    Authors: Han Lv, Jing Sun, Tong Zhang, Ying Hui, Jing Li, Xinyu Zhao, Shuohua Chen, Wenjuan Liu, Xiaoshuai Li, Pengfei Zhao, Shouling Wu, Yanying Liu and Zhenchang Wang
    Citation: BMC Medicine 2024 22:256
    Content type: Research article Published on:

  15. Long COVID potentially increases healthcare utilisation and costs. However, its impact on the NHS remains to be determined.

    Authors: Liang-Yu Lin, Alasdair D. Henderson, Oliver Carlile, Iain Dillingham, Ben F. C. Butler-Cole, Michael Marks, Andrew Briggs, Mark Jit, Laurie A. Tomlinson, Chris Bates, John Parry, Sebastian C. J. Bacon, Ben Goldacre, Amir Mehrkar, Brian MacKenna, Rosalind M. Eggo…
    Citation: BMC Medicine 2024 22:255
    Content type: Research Published on:

  16. Alzheimer’s disease (AD) is a neurodegenerative disease characterized by Aβ plaques and neurofibrillary tangles. Chronic inflammation and synaptic dysfunction lead to disease progression and cognitive decline....

    Authors: Rishabh Singh, Sanskriti Rai, Prahalad Singh Bharti, Sadaqa Zehra, Priya Kumari Gorai, Gyan Prakash Modi, Neerja Rani, Kapil Dev, Krishna Kishore Inampudi, Vishnu V. Y., Prasun Chatterjee, Fredrik Nikolajeff and Saroj Kumar
    Citation: BMC Medicine 2024 22:254
    Content type: Research Published on:

  17. Cognitive dysfunction is one of the common symptoms in patients with major depressive disorder (MDD). Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) have...

    Authors: Xingxing Li, Junyao Liu, Shuochi Wei, Chang Yu, Dongmei Wang, Yuchen Li, Jiaxin Li, Wenhao Zhuang, Rui-Chen-Xi Luo, Yanli Li, Zhiwang Liu, Yuqiu Su, Jimeng Liu, Yongming Xu, Jialin Fan, Guidong Zhu…
    Citation: BMC Medicine 2024 22:253
    Content type: Research article Published on:

  18. Previous studies have shown that the addition of platinum to neoadjuvant chemotherapy (NAC) improved outcomes for patients with triple-negative breast cancer (TNBC). However, no studies have assessed the effic...

    Authors: Cheng Wang, Long Yuan, Xiujuan Wu, Yan Wang, Hao Tian, Guozhi Zhang, Andi Wan, Siyi Xiong, Chengfang Wang, Yuqin Zhou, Dandan Ma, Yangqiu Bao, Man Qu, Jun Jiang, Yi Zhang and Xiaowei Qi
    Citation: BMC Medicine 2024 22:252
    Content type: Research article Published on:

  19. We investigated the association between exercise habits before or after thyroidectomy and incident type 2 diabetes mellitus (T2DM) in patients with thyroid cancer.

    Authors: Jiyun Park, Jin-Hyung Jung, Hyunju Park, Young Shin Song, Soo-Kyung Kim, Yong-Wook Cho, Kyungdo Han and Kyung-Soo Kim
    Citation: BMC Medicine 2024 22:251
    Content type: Research article Published on:

  20. The global population of adults aged 60 and above surpassed 1 billion in 2020, constituting 13.5% of the global populace. Projections indicate a rise to 2.1 billion by 2050. While Hospital-at-Home (HaH) progra...

    Authors: Lulu Lin, Mengyuan Cheng, Yawei Guo, Xiaowen Cao, Weiming Tang, Xin Xu, Weibin Cheng and Zhongzhi Xu
    Citation: BMC Medicine 2024 22:250
    Content type: Research article Published on:

  21. Residing in a disadvantaged neighborhood has been linked to increased mortality. However, the impact of residential segregation and social vulnerability on cause-specific mortality is understudied. Additionall...

    Authors: Kui Deng, Meng Xu, Melis Sahinoz, Qiuyin Cai, Martha J. Shrubsole, Loren Lipworth, Deepak K. Gupta, Debra D. Dixon, Wei Zheng, Ravi Shah and Danxia Yu
    Citation: BMC Medicine 2024 22:249
    Content type: Research article Published on:

  22. Most women use medication during pregnancy. Pregnancy-induced changes in physiology may require antenatal dose alterations. Yet, evidence-based doses in pregnancy are missing. Given historically limited data, ...

    Authors: Charlotte Koldeweij, Mirèse Kleuskens, Carlijn Litjens, Bryony Dean Franklin, Hubertina C. J. Scheepers and Saskia N. de Wildt
    Citation: BMC Medicine 2024 22:248
    Content type: Research article Published on:

  23. Analyzing distance-dependent functional connectivity density (FCD) yields valuable insights into patterns of brain activity. Nevertheless, whether alterations of FCD in non-acute stroke patients are associated...

    Authors: Wenjun Hong, Zaixing Liu, Xin Zhang, Ming Li, Zhixuan Yu, Yuxin Wang, Minmin Wang, Yanan Wu, Shengjie Fang, Bo Yang, Rong Xu and Zhiyong Zhao
    Citation: BMC Medicine 2024 22:247
    Content type: Research article Published on:

  25. Early-life cardiovascular risk factors (CVRFs) are known to be associated with target organ damage during adolescence and premature cardiovascular morbidity and mortality during adulthood. However, contemporar...

    Authors: Qiang Qu, Qixin Guo, Jinjing Shi, Ziqi Chen, Jinyu Sun, Iokfai Cheang, Rongrong Gao, Yanli Zhou, Haifeng Zhang, Shengen Liao, Wenming Yao and Xinli Li
    Citation: BMC Medicine 2024 22:245
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Medicine 2024 22:290

  26. Intracerebral hemorrhage (ICH) is a common stroke type with high morbidity and mortality. There are mainly three surgical methods for treating ICH. Unfortunately, thus far, no specific surgical method has been...

    Authors: Xinghua Xu, Huaping Zhang, Jiashu Zhang, Ming Luo, Qun Wang, Yining Zhao, Zhichao Gan, Bainan Xu and Xiaolei Chen
    Citation: BMC Medicine 2024 22:244
    Content type: Research article Published on:

  27. Seeking and obtaining effective health care for Long COVID remains a challenge in the USA. Women have particularly been impacted, as they are both at higher risk of developing Long COVID and of facing gendered...

    Authors: Linnea I. Laestadius, Jeanine P. D. Guidry, Megan M. Wahl, Paul B. Perrin, Kellie E. Carlyle, Xiaobei Dong, Raouf Gharbo and Celeste Campos-Castillo
    Citation: BMC Medicine 2024 22:243
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Medicine 2024 22:305

  28. Understanding the enduring respiratory consequences of severe COVID-19 is crucial for comprehensive patient care. This study aims to evaluate the impact of post-COVID conditions on respiratory sequelae of seve...

    Authors: Enrique Alfaro, Elena Díaz-García, Sara García-Tovar, Raúl Galera, Raquel Casitas, María Torres-Vargas, Cristina López-Fernández, José M. Añón, Francisco García-Río and Carolina Cubillos-Zapata
    Citation: BMC Medicine 2024 22:242
    Content type: Research article Published on:

  29. Home treatment in child and adolescent psychiatry offers an alternative to conventional inpatient treatment by involving the patient’s family, school, and peers more directly in therapy. Although several revie...

    Authors: Daniel Graf, Christine Sigrist, Isabel Boege, Marialuisa Cavelti, Julian Koenig and Michael Kaess
    Citation: BMC Medicine 2024 22:241
    Content type: Research article Published on:

  30. Accurate prediction of bacteremia is essential for guiding blood culture collection and optimal antibiotic treatment. Shaking chills, defined as a subjective chill sensation with objective body shivering, have...

    Authors: Tetsuro Aita, Hiroaki Nakagawa, Sei Takahashi, Toru Naganuma, Keisuke Anan, Masahiro Banno and Sugihiro Hamaguchi
    Citation: BMC Medicine 2024 22:240
    Content type: Research article Published on:

  31. Mitochondrial (MT) dysfunction is a hallmark of liver diseases. However, the effects of functional variants such as protein truncating variants (PTVs) in MT-related genes on the risk of liver diseases have not...

    Authors: Huangbo Yuan, Zhenqiu Liu, Mingyang Chen, Qiaoyi Xu, Yanfeng Jiang, Tiejun Zhang, Chen Suo and Xingdong Chen
    Citation: BMC Medicine 2024 22:239
    Content type: Research article Published on:

  32. Cerebral palsy (CP), the most common physical disability of childhood, is often accompanied by a range of comorbidities including pain. Pain is highly prevalent in children and young people with CP, yet has be...

    Authors: Adrienne Harvey, Nadine Smith, Meredith Smith, Katarina Ostojic and Carolyn Berryman
    Citation: BMC Medicine 2024 22:238
    Content type: Review Published on:

  33. Immunocompromised individuals are at increased risk of severe COVID-19 outcomes, underscoring the importance of COVID-19 vaccination in this population. The lack of comprehensive real-world data on vaccine upt...

    Authors: Daniel Tzu-Hsuan Chen, Emma Copland, Jennifer A. Hirst, Emma Mi, Sharon Dixon, Carol Coupland and Julia Hippisley-Cox
    Citation: BMC Medicine 2024 22:237
    Content type: Research article Published on:

  34. As global aging accelerates, routinely assessing the functional status and morbidity burden of older patients becomes paramount. The aim of this study is to assess the validity of the comprehensive clinical an...

    Authors: Ahmad Abbadi, Emmanouil Kokoroskos, Matthew Stamets, Davide L. Vetrano, Nicola Orsini, Sölve Elmståhl, Cecilia Fagerström, Anders Wimo, Anders Sköldunger, Johan Sanmartin Berglund, Christina B. Olsson, Caroline Wachtler, Laura Fratiglioni and Amaia Calderón-Larrañaga
    Citation: BMC Medicine 2024 22:236
    Content type: Research article Published on:

  35. Although missed appointments in healthcare have been an area of concern for policy, practice and research, the primary focus has been on reducing single ‘situational’ missed appointments to the benefit of serv...

    Authors: Calum Lindsay, David Baruffati, Mhairi Mackenzie, David A. Ellis, Michelle Major, Catherine A. O’Donnell, Sharon A. Simpson, Andrea E. Williamson and Geoff Wong
    Citation: BMC Medicine 2024 22:235
    Content type: Research Published on:

  36. The standard care for resectable non-small cell lung cancer (NSCLC) involves perioperative therapy combining chemotherapy and immune checkpoint inhibitors, typically lasting 6 to 12 months. However, the optima...

    Authors: Jianzhen Shan, Zhen Liu, Songan Chen, Chengli Du, Bing Li, Lingxiang Ruan, Mei Kong, Lingjie Wang, Miaoyan Du, Shuo Shi, Guoliang Qiao, Tian Tian and Zhengliang Tu
    Citation: BMC Medicine 2024 22:234
    Content type: Research article Published on:

  37. Among patients diagnosed with schizophrenia, the presence of substance use poses an aggravating comorbidity, exerting a negative impact on the course of the disease, adherence to therapeutic regimens, treatmen...

    Authors: Achim Burrer, Stephan T. Egger, Tobias R. Spiller, Matthias Kirschner, Philipp Homan, Erich Seifritz and Stefan Vetter
    Citation: BMC Medicine 2024 22:233
    Content type: Research article Published on:

  38. Geriatric assessment and management (GAM) improve outcomes in older patients with cancer treated with surgery or chemotherapy. It is unclear whether GAM may provide better function and quality of life (QoL), o...

    Authors: Marit Slaaen, Inga Marie Røyset, Ingvild Saltvedt, Bjørn Henning Grønberg, Vidar Halsteinli, Øystein Døhl, Corinna Vossius, Øyvind Kirkevold, Sverre Bergh, Siri Rostoft, Line Oldervoll, Asta Bye, Line Melby, Tove Røsstad, Guro Falk Eriksen, May Ingvild Volungholen Sollid…
    Citation: BMC Medicine 2024 22:232
    Content type: Research article Published on:

  39. Global progress on malaria control has stalled recently, partly due to challenges in universal access to malaria diagnosis and treatment. Community health workers (CHWs) can play a key role in improving access...

    Authors: Andres Garchitorena, Aina Harimanana, Judickaelle Irinantenaina, Hobisoa Léa Razanadranaivo, Tsinjo Fehizoro Rasoanaivo, Dean Sayre, Julie R. Gutman, Reziky Tiandraza Mangahasimbola, Masiarivony Ravaoarimanga, Oméga Raobela, Lala Yvette Razafimaharo, Nicolas Ralemary, Mahefa Andrianasolomanana, Julie Pontarollo, Aline Mukerabirori, Walter Ochieng…
    Citation: BMC Medicine 2024 22:231
    Content type: Research article Published on:

  40. Obesity and central obesity are multifactorial conditions with genetic and non-genetic (lifestyle and environmental) contributions. There is incomplete understanding of whether lifestyle modifies the translati...

    Authors: Mengrong Zhang, Joey Ward, Rona J. Strawbridge, Carlos Celis-Morales, Jill P. Pell, Donald M. Lyall and Frederick K. Ho
    Citation: BMC Medicine 2024 22:230
    Content type: Research article Published on:

  41. Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive ages. Our previous study has implicated a possible link between RNA editing and PCOS, yet the actual role of R...

    Authors: Fan-Sheng Kong, Junjie Feng, Jin-Ping Yao, Yinghua Lu, Tao Guo, Meng Sun, Chun-Yan Ren, Yun-Yun Jin, Yaping Ma and Jian-Huan Chen
    Citation: BMC Medicine 2024 22:229
    Content type: Research article Published on:

  42. Supermarket interventions are promising to promote healthier dietary patterns, but not all individuals may be equally susceptible. We explored whether the effectiveness of nudging and pricing strategies on die...

    Authors: Josine M. Stuber, Joline W. J. Beulens, Juul J. E. van Lierop, Esmee Schuurman, Jeroen Lakerveld and Joreintje D. Mackenbach
    Citation: BMC Medicine 2024 22:228
    Content type: Research Published on:

  43. We quantified SARS-CoV-2 dynamics in different community settings and the direct and indirect effect of the BNT162b2 mRNA vaccine in Monaco for different variants of concern (VOC).

    Authors: Thomas Althaus, Christopher E. Overton, Isabelle Devaux, Thomas House, Arnaud Lapouze, Alexa Troel, Bertrand Vanzo, Margaux Laroche, Alexandre Bordero, Pernille Jorgensen, Richard Pebody and Eric J. Voiglio
    Citation: BMC Medicine 2024 22:227
    Content type: Research article Published on:

  44. Previous studies have linked adolescent motherhood to adverse neurodevelopmental outcomes in offspring, yet the sex-specific effect and underlying mechanisms remain unclear.

    Authors: Tai Ren, Lingli Zhang, Yongjie Liu, Qingli Zhang, Yunjun Sun, Wei Zhou, Like Huang, Ming Wang, Yiwei Pu, Runqi Huang, Jingyu Chen, Hua He, Tailin Zhu, Susu Wang, Weiran Chen, Qianlong Zhang…
    Citation: BMC Medicine 2024 22:226
    Content type: Research article Published on:

  45. Depression and sleep disturbances are associated with increased risks of various diseases and mortality, but their impacts on mortality in cancer survivors remain unclear. The objective of this study was to ch...

    Authors: Ailin Lan, Han Li, Meiying Shen, Daxue Li, Dan Shu, Yang Liu, Haozheng Tang, Kang Li, Yang Peng and Shengchun Liu
    Citation: BMC Medicine 2024 22:225
    Content type: Research article Published on:

  46. Type 2 diabetes is associated with a variety of complications, including micro- and macrovascular complications, neurological manifestations and poor wound healing. Adhering to a Mediterranean Diet (MED) is ge...

    Authors: Changbo Qu, Jinyu Zhao, Jicai Lai, Xinxiang Wu, Peng Huang, Ting Zhu, Yan Li, Taoli Liu, Jinqiu Yuan, Ning Wang, Maikel P Peppelenbosch, Hongda Chen, Bin Xia and Jian Qin
    Citation: BMC Medicine 2024 22:224
    Content type: Research article Published on:

  47. The trajectory of attention-deficit hyperactivity disorder (ADHD) symptoms in children and adolescents, encompassing descending, stable, and ascending patterns, delineates their ADHD status as remission, persi...

    Authors: Yanpei Wang, Leilei Ma, Jiali Wang, Yuyin Ding, Ningyu Liu, Weiwei Men, Shuping Tan, Jia-Hong Gao, Shaozheng Qin, Yong He, Qi Dong and Sha Tao
    Citation: BMC Medicine 2024 22:223
    Content type: Research article Published on:

  48. It is a requirement that medical students are educated in emergencies and feel well prepared for practice as a doctor, yet national surveys show that many students feel underprepared. Virtual reality (VR), com...

    Authors: Risheka Walls, Priyanka Nageswaran, Adrian Cowell, Tunav Sehgal, Thomas White, James McVeigh, Stefan Staykov, Paul Basett, Daniel Mitelpunkt and Amir H. Sam
    Citation: BMC Medicine 2024 22:222
    Content type: Research article Published on:

  49. Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) are implicated in the aetiology of non-communicable diseases. Our study aimed to evaluate associations between NAFLD and MetS with overal...

    Authors: Ana-Lucia Mayén, Mirna Sabra, Elom K. Aglago, Gabriel Perlemuter, Cosmin Voican, Ines Ramos, Charlotte Debras, Jessica Blanco, Vivian Viallon, Pietro Ferrari, Anja Olsen, Anne Tjønneland, Fie Langmann, Christina C. Dahm, Joseph Rothwell, Nasser Laouali…
    Citation: BMC Medicine 2024 22:221
    Content type: Research article Published on:
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