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  1. Risk stratification and management of acute myocardial infarction patients continue to be challenging despite considerable efforts made in the last decades by many clinicians and researchers. The aim of this s...

    Authors: Alessia Vignoli, Leonardo Tenori, Betti Giusti, Panteleimon G. Takis, Serafina Valente, Nazario Carrabba, Daniela Balzi, Alessandro Barchielli, Niccolò Marchionni, Gian Franco Gensini, Rossella Marcucci, Claudio Luchinat and Anna Maria Gori

    Citation: BMC Medicine 2019 17:3

    Content type: Research article

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  2. The SMILES trial showed substantial improvement of depressive symptoms following seven consultations on healthy dieting. The very large effect size on depression reduction seems remarkable and we suggest that ...

    Authors: Marc L. Molendijk, Eiko I. Fried and Willem Van der Does

    Citation: BMC Medicine 2018 16:243

    Content type: Correspondence

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    The original article was published in BMC Medicine 2017 15:23

  3. The original article [1] did not contain comprehensive information regarding two authors’ affiliations that may be considered a potential competing interest.

    Authors: Stewart T. Chang, Violet N. Chihota, Katherine L. Fielding, Alison D. Grant, Rein M. Houben, Richard G. White, Gavin J. Churchyard, Philip A. Eckhoff and Bradley G. Wagner

    Citation: BMC Medicine 2018 16:242

    Content type: Correction

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    The original article was published in BMC Medicine 2018 16:52

  4. The original article [1] contained an error in the presentation of Figure 1; this error has now been rectified and Figure 1 is now presented correctly.

    Authors: Amy Wesolowski, Aimee R. Taylor, Hsiao-Han Chang, Robert Verity, Sofonias Tessema, Jeffrey A. Bailey, T. Alex Perkins, Daniel E. Neafsey, Bryan Greenhouse and Caroline O. Buckee

    Citation: BMC Medicine 2018 16:241

    Content type: Correction

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    The original article was published in BMC Medicine 2018 16:190

  5. The SMILES trial was the first intervention study to test dietary improvement as a treatment strategy for depression. Molendijk et al. propose that expectation bias and difficulties with blinding might account...

    Authors: Felice N. Jacka, Adrienne O’Neil, Catherine Itsiopoulos, Rachelle Opie, Sue Cotton, Mohammadreza Mohebbi, David Castle, Sarah Dash, Cathrine Mihalopoulos, Mary Lou Chatterton, Laima Brazionis, Olivia M. Dean, Allison Hodge and Michael Berk

    Citation: BMC Medicine 2018 16:237

    Content type: Correspondence

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    The original article was published in BMC Medicine 2017 15:23

  6. The original version of this paper [1] did not specify that a website was used in the final year of recruitment, in addition to the other stated recruitment methods.

    Authors: Felice N. Jacka, Adrienne O’Neil, Rachelle Opie, Catherine Itsiopoulos, Sue Cotton, Mohammedreza Mohebbi, David Castle, Sarah Dash, Cathrine Mihalopoulos, Mary Lou Chatterton, Laima Brazionis, Olivia M. Dean, Allison M. Hodge and Michael Berk

    Citation: BMC Medicine 2018 16:236

    Content type: Correction

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    The original article was published in BMC Medicine 2017 15:23

  7. The UK’s National Health Service (NHS) is currently subject to unprecedented financial strain. The identification of unnecessary healthcare resource use has been suggested to reduce spending. However, there is...

    Authors: Jack W. O’Sullivan, Sarah Stevens, Jason Oke, F. D. Richard Hobbs, Chris Salisbury, Paul Little, Ben Goldacre, Clare Bankhead, Jeffrey K. Aronson, Carl Heneghan and Rafael Perera

    Citation: BMC Medicine 2018 16:229

    Content type: Research article

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  8. Mass drug administration (MDA) of antimalarials has re-emerged as a recommended tool for interrupting malaria transmission, but evidence from low endemicity settings is scarce. A trial in Zanzibar found that t...

    Authors: Manuel W. Hetzel and Blaise Genton

    Citation: BMC Medicine 2018 16:239

    Content type: Commentary

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    The original article was published in BMC Medicine 2018 16:215

  9. de Boer and colleagues present a cost-effectiveness analysis based in the Netherlands of two vaccines available for the prevention of herpes zoster. Zostavax® was the first vaccine available for the prevention...

    Authors: Chester B. Good, Natasha Parekh and Inmaculada Hernandez

    Citation: BMC Medicine 2018 16:238

    Content type: Commentary

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    The original article was published in BMC Medicine 2018 16:228

  10. The World Health Organization has set an ambitious goal of eliminating viral hepatitis as a major public health threat by 2030. However, in sub-Saharan Africa, antiviral treatment of chronic hepatitis B (CHB) ...

    Authors: Hailemichael Desalegn, Hanna Aberra, Nega Berhe, Bitsatab Mekasha, Kathrine Stene-Johansen, Henrik Krarup, Andre Puntervold Pereira, Svein Gunnar Gundersen and Asgeir Johannessen

    Citation: BMC Medicine 2018 16:234

    Content type: Research article

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  11. The original article [1] contained an error whereby Table 5 within the Appendix is presented incorrectly. This error has now been corrected and Table 5 is presented appropriately.

    Authors: Kulapong Jayanama, Olga Theou, Joanna M. Blodgett, Leah Cahill and Kenneth Rockwood

    Citation: BMC Medicine 2018 16:235

    Content type: Correction

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    The original article was published in BMC Medicine 2018 16:188

  12. There is clear guidance on the responsibilities of editors to ensure that the research they publish is of the highest possible quality. Poor reporting is unethical and directly impacts patient care. Reporting ...

    Authors: David Moher

    Citation: BMC Medicine 2018 16:233

    Content type: Editorial

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  13. Lifestyle factors conferring increased diabetes risk are associated with elevated basal insulin levels (hyperinsulinaemia). The latter predicts later obesity in children and adolescents.

    Authors: Hubert Kolb, Michael Stumvoll, Werner Kramer, Kerstin Kempf and Stephan Martin

    Citation: BMC Medicine 2018 16:232

    Content type: Review

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  14. As part of a national programme to tackle ethnic inequalities, we conducted a systematic review and meta-analysis of research on ethnic inequalities in pathways to care for adults with psychosis living in Engl...

    Authors: Kristoffer Halvorsrud, James Nazroo, Michaela Otis, Eva Brown Hajdukova and Kamaldeep Bhui

    Citation: BMC Medicine 2018 16:223

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2018 16:240

  15. Cognitive spectrum disorders (CSDs) are common in hospitalised older adults and associated with adverse outcomes. Their association with the maintenance of independent living has not been established. The aim ...

    Authors: Jennifer K. Burton, Bruce Guthrie, Simona M. Hapca, Vera Cvoro, Peter T. Donnan and Emma L. Reynish

    Citation: BMC Medicine 2018 16:231

    Content type: Research article

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  16. Mass drug administration (MDA) has the potential to interrupt malaria transmission and has been suggested as a tool for malaria elimination in low-endemic settings. This study aimed to determine the effectiven...

    Authors: Ulrika Morris, Mwinyi I. Msellem, Humphrey Mkali, Atiqul Islam, Berit Aydin-Schmidt, Irina Jovel, Shija Joseph Shija, Mwinyi Khamis, Safia Mohammed Ali, Lamija Hodzic, Ellinor Magnusson, Eugenie Poirot, Adam Bennett, Michael C. Sachs, Joel Tarning, Andreas Mårtensson…

    Citation: BMC Medicine 2018 16:215

    Content type: Research article

    Published on:

    The Commentary to this article has been published in BMC Medicine 2018 16:239

  17. The predictive validity of postgraduate examinations, such as MRCGP and MRCP(UK) in the UK, is hard to assess, particularly for clinically relevant outcomes. The sanctions imposed on doctors by the UK’s Genera...

    Authors: Richard Wakeford, Kasia Ludka, Katherine Woolf and I. C. McManus

    Citation: BMC Medicine 2018 16:230

    Content type: Research article

    Published on:

  18. The newly registered adjuvanted herpes zoster subunit vaccine (HZ/su) has a higher efficacy than the available live-attenuated vaccine (ZVL). National decision-makers soon need to decide whether to introduce H...

    Authors: Pieter T. de Boer, Alies van Lier, Hester de Melker, Albert J. M. van Wijck, Jan C. Wilschut, Albert Jan van Hoek and Maarten J. Postma

    Citation: BMC Medicine 2018 16:228

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2018 16:238

  19. Emerging evidence suggests intensity of perinatal care influences survival for extremely preterm babies. We evaluated the effect of differences in perinatal care intensity between centres on sensorimotor morbi...

    Authors: Andrei S. Morgan, Laurence Foix L’Helias, Caroline Diguisto, Laetitia Marchand-Martin, Monique Kaminski, Babak Khoshnood, Jennifer Zeitlin, Gérard Bréart, Xavier Durrmeyer, François Goffinet and Pierre-Yves Ancel

    Citation: BMC Medicine 2018 16:227

    Content type: Research article

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  20. Malaria transmission is highly heterogeneous through time and space, and mapping of this heterogeneity is necessary to better understand local dynamics. New targeted policies are needed as numerous countries h...

    Authors: Jordi Landier, Stanislas Rebaudet, Renaud Piarroux and Jean Gaudart

    Citation: BMC Medicine 2018 16:226

    Content type: Commentary

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    The original article was published in Malaria Journal 2018 17:340

  21. Health-related apps have great potential to enhance health and prevent disease globally, but their quality currently varies too much for clinicians to feel confident about recommending them to patients. The ma...

    Authors: Jeremy C. Wyatt

    Citation: BMC Medicine 2018 16:225

    Content type: Opinion

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    The Correction to this article has been published in BMC Medicine 2019 17:144

  22. Previous evidence indicates that sauna bathing is related to a reduced risk of fatal cardiovascular disease (CVD) events in men. The aim of this study was to investigate the relationship between sauna habits a...

    Authors: Tanjaniina Laukkanen, Setor K. Kunutsor, Hassan Khan, Peter Willeit, Francesco Zaccardi and Jari A. Laukkanen

    Citation: BMC Medicine 2018 16:219

    Content type: Research article

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  23. Birth weight and early child growth are important predictors of long-term cardiometabolic disease risk, in line with the Developmental Origins of Health and Disease hypothesis. As human assisted reproductive t...

    Authors: Mark Hann, Stephen A. Roberts, Stephen W. D’Souza, Peter Clayton, Nick Macklon and Daniel R. Brison

    Citation: BMC Medicine 2018 16:224

    Content type: Research article

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  24. Plasmodium ovale spp. and P. malariae cause illness in endemic regions and returning travellers. Far less is known about these species than P. falciparum and P. vivax.

    Authors: Laura E. B. Nabarro, Debbie Nolder, Claire Broderick, Behzad Nadjm, Valerie Smith, Marie Blaze, Anna M. Checkley, Peter L. Chiodini, Colin J. Sutherland and Christopher J. M. Whitty

    Citation: BMC Medicine 2018 16:218

    Content type: Research article

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  25. Understanding the long-term health impacts of the early-life exposome requires the characterization and assimilation of multi ‘omics’ data to ultimately link molecular changes to exposures. In this way, marker...

    Authors: Alicia DiBattista and Pranesh Chakraborty

    Citation: BMC Medicine 2018 16:222

    Content type: Commentary

    Published on:

    The original article was published in BMC Medicine 2018 16:202

  26. The past 15 years have seen the emergence of a new paradigm in medical research, namely of people living with medical conditions (whether patients, parents, or caregivers) using digital tools to conduct N-of-1...

    Authors: Paul Wicks

    Citation: BMC Medicine 2018 16:217

    Content type: Editorial

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  27. Pancreatic cancer is the fourth leading cause of cancer-related death in the United States, with increasing incidence. The mortality rate of pancreatic cancer is rising rapidly, and is projected to be the seco...

    Authors: Huiyun Zhu, Tuo Li, Yiqi Du and Min Li

    Citation: BMC Medicine 2018 16:214

    Content type: Editorial

    Published on:

  28. Improving clinical outcomes and quality of care in diseases such as sepsis, which are heterogeneous in their presenting signs and symptoms, is a challenge. One approach is to utilise the Functional Analysis Re...

    Authors: Damian Roland

    Citation: BMC Medicine 2018 16:213

    Content type: Commentary

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    The original article was published in BMC Medicine 2018 16:174

  29. Adequate reporting of adaptive designs (ADs) maximises their potential benefits in the conduct of clinical trials. Transparent reporting can help address some obstacles and concerns relating to the use of ADs....

    Authors: Munyaradzi Dimairo, Elizabeth Coates, Philip Pallmann, Susan Todd, Steven A. Julious, Thomas Jaki, James Wason, Adrian P. Mander, Christopher J. Weir, Franz Koenig, Marc K. Walton, Katie Biggs, Jon Nicholl, Toshimitsu Hamasaki, Michael A. Proschan, John A. Scott…

    Citation: BMC Medicine 2018 16:210

    Content type: Guideline

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  30. It is presumed that pharmacological and non-pharmacological treatment of prenatal common mental disorders can mitigate associated adverse effects in offspring, yet strong evidence for the prophylactic benefits...

    Authors: Marlies E. Brouwer, Alishia D. Williams, Sam E. van Grinsven, Pim Cuijpers, Mijke P. Lambregtse-van den Berg, Huibert Burger and Claudi L. H. Bockting

    Citation: BMC Medicine 2018 16:208

    Content type: Research article

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  31. Spatial epidemiology is a rapidly advancing field, pushing our abilities to measure, monitor and map pathogens at increasingly finer spatiotemporal scales. However, these scales often do not align with the abi...

    Authors: Andrew J. Tatem

    Citation: BMC Medicine 2018 16:209

    Content type: Commentary

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  32. Concerns have been raised that observing other people using e-cigarettes may undermine motivation to quit by renormalising smoking. This study aimed to explore associations between regular exposure to other pe...

    Authors: Sarah E. Jackson, Emma Beard, Susan Michie, Lion Shahab, Tobias Raupach, Robert West and Jamie Brown

    Citation: BMC Medicine 2018 16:206

    Content type: Research article

    Published on:

  33. In 2005, the FDA cautioned that exposure to paroxetine, a selective serotonin reuptake inhibitor (SSRI), during the first trimester of pregnancy may increase the risk of cardiac malformations. Since then, the ...

    Authors: Shan-Yan Gao, Qi-Jun Wu, Ce Sun, Tie-Ning Zhang, Zi-Qi Shen, Cai-Xia Liu, Ting-Ting Gong, Xin Xu, Chao Ji, Dong-Hui Huang, Qing Chang and Yu-Hong Zhao

    Citation: BMC Medicine 2018 16:205

    Content type: Research article

    Published on:

  34. Environment and diet in early life can affect development and health throughout the life course. Metabolic phenotyping of urine and serum represents a complementary systems-wide approach to elucidate environme...

    Authors: Chung-Ho E. Lau, Alexandros P. Siskos, Léa Maitre, Oliver Robinson, Toby J. Athersuch, Elizabeth J. Want, Jose Urquiza, Maribel Casas, Marina Vafeiadi, Theano Roumeliotaki, Rosemary R. C. McEachan, Rafaq Azad, Line S. Haug, Helle M. Meltzer, Sandra Andrusaityte, Inga Petraviciene…

    Citation: BMC Medicine 2018 16:202

    Content type: Research article

    Published on:

    The Commentary to this article has been published in BMC Medicine 2018 16:222

  35. Several quinoline and structurally related antimalarial drugs are associated with cardiovascular side effects, particularly hypotension and electrocardiographic QT interval prolongation. A prolonged QT interva...

    Authors: Ilsa L. Haeusler, Xin Hui S. Chan, Philippe J. Guérin and Nicholas J. White

    Citation: BMC Medicine 2018 16:200

    Content type: Research article

    Published on:

  36. Maternal gestational diabetes (GDM) is an established risk factor for large size at birth, but its influence on intrauterine fetal growth in different ethnic populations is less well understood. Here, we exami...

    Authors: Judith S. Brand, Jane West, Derek Tuffnell, Philippa K. Bird, John Wright, Kate Tilling and Debbie A. Lawlor

    Citation: BMC Medicine 2018 16:203

    Content type: Research article

    Published on:

  37. Gestational weight gain differs according to pre-pregnancy body mass index and is related to the risks of adverse maternal and child health outcomes. Gestational weight gain charts for women in different pre-p...

    Authors: Susana Santos, Iris Eekhout, Ellis Voerman, Romy Gaillard, Henrique Barros, Marie-Aline Charles, Leda Chatzi, Cécile Chevrier, George P. Chrousos, Eva Corpeleijn, Nathalie Costet, Sarah Crozier, Myriam Doyon, Merete Eggesbø, Maria Pia Fantini, Sara Farchi…

    Citation: BMC Medicine 2018 16:201

    Content type: Research article

    Published on:

  38. Factors driving inter-individual differences in immune responses upon different types of prenatal malaria exposure (PME) and subsequent risk of malaria in infancy remain poorly understood. In this study, we ex...

    Authors: Hamtandi Magloire Natama, Gemma Moncunill, Eduard Rovira-Vallbona, Héctor Sanz, Hermann Sorgho, Ruth Aguilar, Maminata Coulibaly-Traoré, M. Athanase Somé, Susana Scott, Innocent Valéa, Petra F. Mens, Henk D. F. H. Schallig, Luc Kestens, Halidou Tinto, Carlota Dobaño and Anna Rosanas-Urgell

    Citation: BMC Medicine 2018 16:198

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2018 16:212

  39. Childhood malnutrition remains highly prevalent in low-income countries, and a 40% reduction in under-5 year stunting is WHO’s top Global Target 2025. Disappointingly, meta-analyses of intensive nutrition inte...

    Authors: Mayya Husseini, Momodou K Darboe, Sophie E Moore, Helen M Nabwera and Andrew M Prentice

    Citation: BMC Medicine 2018 16:199

    Content type: Research article

    Published on:

  40. The RTS,S/AS01E vaccine provides partial protection against malaria in African children, but immune responses have only been partially characterized and do not reliably predict protective efficacy. We aimed to...

    Authors: Itziar Ubillos, Aintzane Ayestaran, Augusto J Nhabomba, David Dosoo, Marta Vidal, Alfons Jiménez, Chenjerai Jairoce, Hèctor Sanz, Ruth Aguilar, Nana Aba Williams, Núria Díez-Padrisa, Maximilian Mpina, Hermann Sorgho, Selidji Todagbe Agnandji, Simon Kariuki, Benjamin Mordmüller…

    Citation: BMC Medicine 2018 16:197

    Content type: Research article

    Published on:

  41. The host, microbial, and environmental factors that contribute to variation in tuberculosis (TB) disease are incompletely understood. Accumulating evidence suggests that one driver of geographic variation in T...

    Authors: Kirsten E Wiens, Lauren P Woyczynski, Jorge R Ledesma, Jennifer M Ross, Roberto Zenteno-Cuevas, Amador Goodridge, Irfan Ullah, Barun Mathema, Joel Fleury Djoba Siawaya, Molly H Biehl, Sarah E Ray, Natalia V Bhattacharjee, Nathaniel J Henry, Robert C Reiner Jr, Hmwe H Kyu, Christopher J L Murray…

    Citation: BMC Medicine 2018 16:196

    Content type: Research article

    Published on:

  42. Despite substantial improvement in the control of malaria and decreased prevalence of malnutrition over the past two decades, both conditions remain heavy burdens that cause hundreds of thousands of deaths in ...

    Authors: D Das, R F Grais, E A Okiro, K Stepniewska, R Mansoor, S van der Kam, D J Terlouw, J Tarning, K I Barnes and P J Guerin

    Citation: BMC Medicine 2018 16:186

    Content type: Research article

    Published on:

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