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  1. Data sharing is essential for promoting scientific discoveries and informed decision-making in clinical practice. In 2013, PhRMA/EFPIA recognised the importance of data sharing and supported initiatives to enh...

    Authors: Natansh D. Modi, Ganessan Kichenadasse, Tammy C. Hoffmann, Mark Haseloff, Jessica M. Logan, Areti A. Veroniki, Rebecca L. Venchiarutti, Amelia K. Smit, Haitham Tuffaha, Harindra Jayasekara, Arkady Manning-Bennet, Erin Morton, Ross A. McKinnon, Andrew Rowland, Michael J. Sorich and Ashley M. Hopkins
    Citation: BMC Medicine 2023 21:400
  2. We aimed to model total charges for the most prevalent multimorbidity combinations in the USA and assess model accuracy across Asian/Pacific Islander, African American, Biracial, Caucasian, Hispanic, and Nativ...

    Authors: Manal Alshakhs, Patricia J. Goedecke, James E. Bailey and Charisse Madlock-Brown
    Citation: BMC Medicine 2023 21:399
  3. Metabolic dysfunction-associated fatty liver disease (MAFLD) is a newly defined condition encompassing hepatic steatosis and metabolic dysfunction. However, the relationship between MAFLD and multi-system dise...

    Authors: Yu Jia, Dongze Li, Yi You, Jing Yu, Wenli Jiang, Yi Liu, Rui Zeng, Zhi Wan, Yi Lei and Xiaoyang Liao
    Citation: BMC Medicine 2023 21:398
  4. Single low-dose primaquine (SLDPQ) effectively blocks the transmission of Plasmodium falciparum malaria, but anxiety remains regarding its haemolytic potential in patients with glucose-6-phopshate dehydrogenase (...

    Authors: Marie A. Onyamboko, Peter Olupot-Olupot, Winifred Were, Cate Namayanja, Peter Onyas, Harriet Titin, Joy Baseke, Rita Muhindo, Daddy K. Kayembe, Pauline O. Ndjowo, Benjamin B. Basara, Charles B. Okalebo, Thomas N. Williams, Sophie Uyoga, Chiraporn Taya, Adeola Bamisaiye…
    Citation: BMC Medicine 2023 21:397
  5. Thoracic aortic dissection (TAD) is a life-threatening disease caused by an intimal tear in the aorta. The histological characteristics differ significantly between the tear area (TA) and the distant area. Pre...

    Authors: Yixuan Sheng, Liying Wu, Yuan Chang, Wendao Liu, Menghao Tao, Xiao Chen, Xiong Zhang, Bin Li, Ningning Zhang, Dongting Ye, Chunxi Zhang, Daliang Zhu, Haisen Zhao, Aijun Chen, Haisheng Chen and Jiangping Song
    Citation: BMC Medicine 2023 21:396
  6. GT90001 (also known as PF-03446962) is an anti-ALK-1 monoclonal antibody and has shown activity in hepatocellular carcinoma (HCC). This phase 1b/2 study was designed to determine the recommended phase 2 dose (...

    Authors: Chiun Hsu, Yi-Fang Chang, Chia-Jui Yen, Yu-Wei Xu, Min Dong and You-Zhi Tong
    Citation: BMC Medicine 2023 21:395
  7. Previous studies that assessed the risk of cardiovascular outcomes in survivors of coronavirus disease 2019 (COVID-19) were likely limited by lack of generalizability and selection of controls nonrepresentativ...

    Authors: Min-Taek Lee, Moon Seong Baek, Tae Wan Kim, Sun-Young Jung and Won-Young Kim
    Citation: BMC Medicine 2023 21:394
  8. Breastfeeding has long been associated with numerous benefits for both mothers and infants. While some observational studies have explored the relationship between breastfeeding and mental health outcomes in m...

    Authors: Polina Bugaeva, Inna Arkusha, Rinat Bikaev, Igor Kamenskiy, Aleksandra Pokrovskaya, Yasmin El-Taravi, Valeria Caso, Alla Avedisova, Derek K. Chu, Jon Genuneit, Gabriel Torbahn, Timothy R. Nicholson, Dina Baimukhambetova, Aigun Mursalova, Anastasia Kolotilina, Svetlana Gadetskaya…
    Citation: BMC Medicine 2023 21:393
  9. Integrating a joint approach to chronic disease management within the context of a couple has immense potential as a valuable strategy for both prevention and treatment. Although spousal concordance has been r...

    Authors: Hoyoung An, Hee Won Yang, Dae Jong Oh, Eunji Lim, Jin Shin, Dong Gyu Moon, Seung Wan Suh, Seonjeong Byun, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu…
    Citation: BMC Medicine 2023 21:367
  10. Fatty acid binding protein 4 (FABP-4) is a lipid-binding adipokine upregulated in obesity, which may facilitate fatty acid supply for tumor growth and promote insulin resistance and inflammation and may thus p...

    Authors: Katharina Nimptsch, Krasimira Aleksandrova, Thu Thi Pham, Nikos Papadimitriou, Jürgen Janke, Sofia Christakoudi, Alicia Heath, Anja Olsen, Anne Tjønneland, Matthias B. Schulze, Verena Katzke, Rudolf Kaaks, Bethany van Guelpen, Justin Harbs, Domenico Palli, Alessandra Macciotta…
    Citation: BMC Medicine 2023 21:391
  11. Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with C...

    Authors: Sangeetha Shyam, Jesús Francisco García-Gavilán, Indira Paz-Graniel, José J. Gaforio, Miguel Ángel Martínez-González, Dolores Corella, J. Alfredo Martínez, Ángel M. Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J. Tinahones, José Lapetra, J. Luís Serra-Majem…
    Citation: BMC Medicine 2023 21:390
  12. The risk of extracolonic cancer is increased in inflammatory bowel disease (IBD) patients, but it is not clear whether there is a causal relationship. We aimed to systematically estimate the causal relationshi...

    Authors: Hui Gao, Shuhao Zheng, Xin Yuan, Jiarong Xie and Lei Xu
    Citation: BMC Medicine 2023 21:389
  13. Dipeptidyl peptidase-4 inhibitors (DPP-4i) have become firmly established in treatment algorithms and national guidelines for improving glycemic control in type 2 diabetes mellitus (T2DM).To report the finding...

    Authors: Mingtong Xu, Kan Sun, Wenjie Xu, Chuan Wang, Dewen Yan, Shu Li, Li Cong, Yinzhen Pi, Weihong Song, Qingyuan Sun, Rijun Xiao, Weixia Peng, Jianping Wang, Hui Peng, Yawei Zhang, Peng Duan…
    Citation: BMC Medicine 2023 21:388
  14. We previously demonstrated that CD34 + cell transplantation in animals healed intractable fractures via osteogenesis and vasculogenesis; we also demonstrated the safety and efficacy of this cell therapy in an ...

    Authors: Ryosuke Kuroda, Takahiro Niikura, Tomoyuki Matsumoto, Tomoaki Fukui, Keisuke Oe, Yutaka Mifune, Hironobu Minami, Hiroshi Matsuoka, Kimikazu Yakushijin, Yoshiharu Miyata, Shinichiro Kawamoto, Tatsuo Kagimura, Yasuyuki Fujita and Atsuhiko Kawamoto
    Citation: BMC Medicine 2023 21:386
  15. Few studies have investigated the joint effects of sleep traits on the risk of acute myocardial infarction (AMI). No previous study has used factorial Mendelian randomization (MR) which may reduce confounding,...

    Authors: Nikhil Arora, Laxmi Bhatta, Eivind Schjelderup Skarpsno, Håvard Dalen, Bjørn Olav Åsvold, Ben Michael Brumpton, Rebecca Claire Richmond and Linn Beate Strand
    Citation: BMC Medicine 2023 21:385
  16. An increased number of resources are allocated on cancer biomarker discovery, but very few of these biomarkers are clinically adopted. To bridge the gap between Biomarker discovery and clinical use, we aim to ...

    Authors: Katerina-Vanessa Savva, Michal Kawka, Bhamini Vadhwana, Rahul Penumaka, Imogen Patton, Komal Khan, Claire Perrott, Saranya Das, Maxime Giot, Stella Mavroveli, George B. Hanna, Melody Zhifang Ni and Christopher J. Peters
    Citation: BMC Medicine 2023 21:383
  17. Smoking continues to be a leading risk factor for several diseases globally. We hypothesised that an intervention delivered via text messages could help individuals who were looking to quit.

    Authors: Jenny Blomqvist, Katarina Ulfsdotter Gunnarsson, Preben Bendtsen and Marcus Bendtsen
    Citation: BMC Medicine 2023 21:382
  18. Health systems’ weakness remains one of the primary obstacles towards achieving universal access to quality healthcare in low-income settings. Performance-based financing (PBF) programs have been increasingly ...

    Authors: Gil Shapira, Emma Clarke-Deelder, Baudouin Makuma Booto, Hadia Samaha, György Bèla Fritsche, Michel Muvudi, Dominique Baabo, Delphin Antwisi, Didier Ramanana, Saloua Benami and Günther Fink
    Citation: BMC Medicine 2023 21:381
  19. Currently, evidence about the long-term consequences of COVID-19 on return to work and health-related quality of life (HRQoL) is limited. We evaluated return to work and its associations with baseline characte...

    Authors: L. M. Bek, J. C. Berentschot, M. E. Hellemons, S. C. Remerie, J. van Bommel, J. G. J. V. Aerts, G. M. Ribbers, H. J. G. van den Berg-Emons and M. H. Heijenbrok-Kal
    Citation: BMC Medicine 2023 21:380
  20. The use of alcohol-flavored beverages not containing alcohol (hereinafter referred to as non-alcoholic beverages) is recommended to reduce alcohol consumption. However, it is unclear if this reduces excessive ...

    Authors: Hisashi Yoshimoto, Kyoko Kawaida, Shohei Dobashi, Go Saito and Yukiko Owaki
    Citation: BMC Medicine 2023 21:379
  21. Perinatal mental illness affects one third of new and expectant mothers. Individuals from ethnic minority groups experience higher rates of mental health problems and higher suicide rates. Despite this, women ...

    Authors: Kiren Bains, Sarah Bicknell, Nikolina Jovanović, Maev Conneely, Rosemarie McCabe, Alex Copello, Jessica Fletcher-Rogers, Stefan Priebe and Jelena Janković
    Citation: BMC Medicine 2023 21:370

    The Commentary to this article has been published in BMC Medicine 2023 21:371

  22. Although non-pharmacological smoking cessation measures have been widely used among smokers, current research evidence on the effects of smoking cessation is inconsistent and of mixed quality. Moreover, there ...

    Authors: Tao Nian, Kangle Guo, Wendi Liu, Xinxin Deng, Xiaoye Hu, Meng Xu, Fenfen E, Ziyi Wang, Guihang Song, Kehu Yang, Xiuxia Li and Wenru Shang
    Citation: BMC Medicine 2023 21:378
  23. Multiple myeloma (MM) is a severely debilitating and fatal B-cell neoplastic disease. The discovery of disease-associated proteins with causal genetic evidence offers a chance to uncover novel therapeutic targ...

    Authors: Qiangsheng Wang, Qiqin Shi, Zhenqian Wang, Jiawen Lu and Jian Hou
    Citation: BMC Medicine 2023 21:377
  24. The effect of the combination of an anti-angiogenic agent with a poly (ADP-ribose) polymerase (PARP) inhibitor in cancer treatment is unclear. We assessed the oral combination of fuzuloparib, a PARP inhibitor,...

    Authors: Yaxin Liu, Wei Wang, Rutie Yin, Youzhong Zhang, Yu Zhang, Keqiang Zhang, Hongming Pan, Ke Wang, Ge Lou, Guiling Li, Ruyan Zhang, Kun Li, Jing Rao, Ben Zhang, Yuting Wang, Quanren Wang…
    Citation: BMC Medicine 2023 21:376
  25. Emulating randomized controlled trials (RCTs) by real-world evidence (RWE) studies would benefit future clinical and regulatory decision-making by balancing the limitations of RCT. We aimed to evaluate whether...

    Authors: Dongwon Yoon, Han Eol Jeong, Sohee Park, Seng Chan You, Soo-Mee Bang and Ju-Young Shin
    Citation: BMC Medicine 2023 21:375
  26. After the first COVID-19 wave caused by the ancestral lineage, the pandemic has been fueled from the continuous emergence of new SARS-CoV-2 variants. Understanding key time-to-event periods for each emerging v...

    Authors: Xiangyanyu Xu, Yanpeng Wu, Allisandra G. Kummer, Yuchen Zhao, Zexin Hu, Yan Wang, Hengcong Liu, Marco Ajelli and Hongjie Yu
    Citation: BMC Medicine 2023 21:374
  27. In sub-Saharan Africa, less than 1% of treatment-eligible chronic hepatitis B (CHB) patients receive antiviral therapy. Experiences from local CHB programs are needed to inform treatment guidelines and policie...

    Authors: Hailemichael Desalegn, Stian Magnus Staurung Orlien, Hanna Aberra, Eyerusalem Mamo, Sine Grude, Kristina Hommersand, Nega Berhe, Svein Gunnar Gundersen and Asgeir Johannessen
    Citation: BMC Medicine 2023 21:373
  28. Authors: Keren Jia, Yang Chen, Yu Sun, Yajie Hu, Lei Jiao, Jie Ma, Jiajia Yuan, Changsong Qi, Yanyan Li, Jifang Gong, Jing Gao, Xiaotian Zhang, Jian Li, Cheng Zhang and Lin Shen
    Citation: BMC Medicine 2023 21:369

    The original article was published in BMC Medicine 2022 20:223

  29. Authors: Long Gao, Yanyan Lin, Ping Yue, Shuyan Li, Yong Zhang, Ningning Mi, Mingzhen Bai, Wenkang Fu, Zhili Xia, Ningzu Jiang, Jie Cao, Man Yang, Yanni Ma, Fanxiang Zhang, Chao Zhang, Joseph W. Leung…
    Citation: BMC Medicine 2023 21:368

    The original article was published in BMC Medicine 2023 21:294

  30. Multitarget tyrosine kinase inhibitors (mTKIs) such as Regorafenib and Sorafenib have already been approved for the treatment of many solid tumours. However, the efficacy of mTKIs in colorectal cancer (CRC) is...

    Authors: Xiaolin Lu, Ruiqi Liu, Yuanyu Liao, Luying Cui, Haoxiu Sun, Dongzhi Zhang, Bojun Wang, Lin Fang, Xin Guan, Yuanfei Yao, Chao Liu and Yanqiao Zhang
    Citation: BMC Medicine 2023 21:366
  31. Syncope management is fraught with unnecessary tests and frequent failure to establish a diagnosis. We evaluated the potential of implementing the 2018 European Society of Cardiology (ESC) Syncope Guidelines r...

    Authors: M. Ghariq, W. B. van den Hout, O. M. Dekkers, M. Bootsma, B. de Groot, J. G. J. Groothuis, M. P. M. Harms, M. E. W. Hemels, E. C. A. Kaal, E. M. Koomen, F. J. de Lange, S. Y. G. Peeters, I. A. van Rossum, J. H. W. Rutten, E. W. van Zwet, J. G. van Dijk…
    Citation: BMC Medicine 2023 21:365
  32. Epigenetic age is an estimator of biological age based on DNA methylation; its discrepancy from chronologic age warrants further investigation. We recently reported that greater polyphenol intake benefitted ec...

    Authors: Anat Yaskolka Meir, Maria Keller, Anne Hoffmann, Ehud Rinott, Gal Tsaban, Alon Kaplan, Hila Zelicha, Tobias Hagemann, Uta Ceglarek, Berend Isermann, Ilan Shelef, Matthias Blüher, Michael Stumvoll, Jun Li, Sven-Bastian Haange, Beatrice Engelmann…
    Citation: BMC Medicine 2023 21:364
  33. Some patients infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) go on to experience post-COVID-19 condition or long COVID. Preliminary findings have given rise to the theory that long ...

    Authors: Umer Syed, Anuradhaa Subramanian, David C. Wraith, Janet M. Lord, Kirsty McGee, Krishna Ghokale, Krishnarajah Nirantharakumar and Shamil Haroon
    Citation: BMC Medicine 2023 21:363
  34. Overtreatment poses a challenge to healthcare systems due to harmful consequences of avoidable side-effects and costs. This study presents the first account for examining the feasibility of placebo use for red...

    Authors: E. M. Krockow, T. Emerson, E. Youssef, S. Scott and S. Tromans
    Citation: BMC Medicine 2023 21:362
  35. This is the first clinical trial to investigate the effectiveness of maggot debridement therapy (MDT) for full-thickness burn injuries in comparison to conventional silver dressings.

    Authors: Jasem Gaffari, Kamran Akbarzadeh, Mozhgan Baniardalani, Reza Hosseini, Safdar Masoumi, Zahra Sadat Amiri, Razieh Shabani Kordshouli, Javad Rafinejad and Mostafa Dahmardehei
    Citation: BMC Medicine 2023 21:361
  36. Bone marrow (BM) transplantation is a life-saving therapy for hematological diseases, and the BM harbors also highly useful (progenitor) cell types for novel cell therapies manufacture. Yet, the BM collection ...

    Authors: Jeremy Epah, Gabriele Spohn, Kathrin Preiß, Markus M. Müller, Johanna Dörr, Rainer Bauer, Shabnam Daqiq-Mirdad, Joachim Schwäble, Stefanie N. Bernas, Alexander H. Schmidt, Erhard Seifried and Richard Schäfer
    Citation: BMC Medicine 2023 21:360
  37. During the COVID-19 pandemic, a variety of clinical decision support systems (CDSS) were developed to aid patient triage. However, research focusing on the interaction between decision support systems and huma...

    Authors: Daniel Laxar, Magdalena Eitenberger, Mathias Maleczek, Alexandra Kaider, Fabian Peter Hammerle and Oliver Kimberger
    Citation: BMC Medicine 2023 21:359
  38. In the course of the SARS-CoV-2 pandemic, multiple vaccines were developed. Little was known about reactogenicity and safety in comparison to established vaccines, e.g. influenza, pneumococcus, or herpes zoste...

    Authors: Felix Werner, Nikoletta Zeschick, Thomas Kühlein, Philipp Steininger, Klaus Überla, Isabelle Kaiser, Maria Sebastião, Susann Hueber and Lisette Warkentin
    Citation: BMC Medicine 2023 21:358
  39. Currently, the clinical strategy for diagnosis of non-muscle invasive bladder cancer (NMIBC) such as cystoscopy and cytology are invasive and/or with limited accuracy. OncoUrine, a urinary assay for mutation a...

    Authors: Hai Huang, Ao Liu, Yiming Liang, Yaqun Xin, Jiacheng Liu, Yining Hao, Da Huang, Lu Chen, Wei Li, Guangliang Jiang, Yuhua Huang, Yaoting Xu, Jie Zhang, Tonghui Ma, Danfeng Xu and Yi Gao
    Citation: BMC Medicine 2023 21:357
  40. Financial risk protection (FRP) is a key component of universal health coverage (UHC): all individuals must be able to obtain the health services they need without experiencing financial hardship. In many low-...

    Authors: Sarah Bolongaita, Yeeun Lee, Kjell Arne Johansson, Øystein A. Haaland, Mieraf Taddesse Tolla, Jongwook Lee and Stéphane Verguet
    Citation: BMC Medicine 2023 21:356
  41. Major depressive disorder (MDD) has a significant impact on global burden of disease. Complications in clinical management can occur when response to pharmacological modalities is considered inadequate and sym...

    Authors: Vasilios Karageorgiou, Francesco Casanova, Jessica O’Loughlin, Harry Green, Trevelyan J. McKinley, Jack Bowden and Jessica Tyrrell
    Citation: BMC Medicine 2023 21:355
  42. Sex and gender are fundamental aspects of health and wellbeing. Yet many research studies fail to consider sex or gender differences, and even when they do this is often limited to merely cataloguing such diff...

    Authors: Sanne A. E. Peters and Mark Woodward
    Citation: BMC Medicine 2023 21:354
  43. Despite epidemiological evidence associating gallstone disease (GSD) with cardiovascular disease (CVD), a dilemma remains on the role of cholecystectomy in modifying the risk of CVD. We aimed to characterize t...

    Authors: Li Zhang, Wenqiang Zhang, Lin He, Huijie Cui, Yutong Wang, Xueyao Wu, Xunying Zhao, Peijing Yan, Chao Yang, Changfeng Xiao, Mingshuang Tang, Lin Chen, Chenghan Xiao, Yanqiu Zou, Yunjie Liu, Yanfang Yang…
    Citation: BMC Medicine 2023 21:353
  44. Multimorbidity is common in women across the life course. Preterm birth is the single biggest cause of neonatal mortality and morbidity. We aim to estimate the prevalence of multimorbidity in pregnant women an...

    Authors: Amaya Azcoaga-Lorenzo, Adeniyi Francis Fagbamigbe, Utkarsh Agrawal, Mairead Black, Muhammad Usman, Siang Ing Lee, Kelly-Ann Eastwood, Ngawai Moss, Rachel Plachcinski, Catherine Nelson-Piercy, Sinead Brophy, Dermot O’Reilly, Krishnarajah Nirantharakumar and Colin McCowan
    Citation: BMC Medicine 2023 21:352
  45. Diets rich in plant-based foods are associated with lower risks of non-alcoholic fatty liver disease (NAFLD), while the prospective evidence is limited. We aimed to examine longitudinal associations of plant-b...

    Authors: Yanling Lv, Shuang Rong, Yan Deng, Wei Bao, Yang Xia and Liangkai Chen
    Citation: BMC Medicine 2023 21:351
  46. Few studies have investigated associations between adiposity and reproductive factors using causal methods, both of which have a number of consequences on women’s health. Here we assess whether adiposity at di...

    Authors: Claire Prince, Laura D. Howe, Gemma C. Sharp, Abigail Fraser and Rebecca C. Richmond
    Citation: BMC Medicine 2023 21:350
  47. Authors: Ruth H. Jack, Carol A. C. Coupland, Rebecca M. Joseph, Chris Hollis, Richard Morriss, Roger David Knaggs, Andrea Cipriani, Samuele Cortese and Julia Hippisley-Cox
    Citation: BMC Medicine 2023 21:346

    The original article was published in BMC Medicine 2020 18:93

    The Correspondence to this article has been published in BMC Medicine 2023 21:345