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  1. Adaptive designs are a class of methods for improving efficiency and patient benefit of clinical trials. Although their use has increased in recent years, research suggests they are not used in many situations...

    Authors: James M. S. Wason, Munyaradzi Dimairo, Katie Biggs, Sarah Bowden, Julia Brown, Laura Flight, Jamie Hall, Thomas Jaki, Rachel Lowe, Philip Pallmann, Mark A. Pilling, Claire Snowdon, Matthew R. Sydes, Sofía S. Villar, Christopher J. Weir, Nina Wilson…
    Citation: BMC Medicine 2022 20:254
  2. Although cholesterol metabolism is a common pathway for the development of antitumor drugs, there are no specific targets and drugs for clinical use. Here, based on our previous study of sterol O-acyltransfera...

    Authors: Zhihua Wang, Miaomiao Wang, Mengxin Zhang, Kaikun Xu, Xinshuai Zhang, Yi Xie, Yiming Zhang, Cheng Chang, Xiaolu Li, Aihua Sun and Fuchu He
    Citation: BMC Medicine 2022 20:292
  3. Both sleep quality and quantity are essential for normal brain development throughout childhood; however, the association between preterm birth and sleep problems in preschoolers is not yet clear, and the effe...

    Authors: Jiajun Lyu, John A. Groeger, Anna L. Barnett, Haifeng Li, Lei Wang, Jiajia Zhang, Wenchong Du and Jing Hua
    Citation: BMC Medicine 2022 20:253
  4. Prostate cancer is an epidemic of the modern age, and despite efforts to improve awareness, it remains the case that mortality has hardly altered over the decades, driven largely by late presentation. There is...

    Authors: Vincent J. Gnanapragasam, David Greenberg and Neil Burnet
    Citation: BMC Medicine 2022 20:264
  5. Early detection of breast cancer (BC) through mammography screening (MAM) is known to reduce mortality. We examined the differential effect that mammography has on BC characteristics and overall survival and t...

    Authors: Zi Lin Lim, Peh Joo Ho, Alexis Jiaying Khng, Yen Shing Yeoh, Amanda Tse Woon Ong, Benita Kiat Tee Tan, Ern Yu Tan, Su-Ming Tan, Geok Hoon Lim, Jung Ah Lee, Veronique Kiak-Mien Tan, Jesse Hu, Jingmei Li and Mikael Hartman
    Citation: BMC Medicine 2022 20:239
  6. Chronic kidney disease (CKD) in people with diabetes is becoming an increasing major public health concern, disproportionately burdening low- and middle-income countries (LMICs). This rising burden is due to v...

    Authors: Cindy George, Justin B. Echouffo-Tcheugui, Bernard G. Jaar, Ikechi G. Okpechi and Andre P. Kengne
    Citation: BMC Medicine 2022 20:247
  7. Although sexually transmitted infections are regarded as the main cause of tubal infertility, the association between the common vaginal microbiome and female fecundability has yet to be determined. The object...

    Authors: Xiang Hong, Jun Zhao, Jiechen Yin, Fanqi Zhao, Wei Wang, Xiaoling Ding, Hong Yu, Xu Ma and Bei Wang
    Citation: BMC Medicine 2022 20:246
  8. Authors: Bożena Wielgoszewska, Jane Maddock, Michael J. Green, Giorgio Di Gessa, Sam Parsons, Gareth J. Griffith, Jazz Croft, Anna J. Stevenson, Charlotte Booth, Richard J. Silverwood, David Bann, Praveetha Patalay, Alun D. Hughes, Nishi Chaturvedi, Laura D. Howe, Emla Fitzsimons…
    Citation: BMC Medicine 2022 20:285

    The original article was published in BMC Medicine 2022 20:147

  9. The combination of immune checkpoint inhibitors (ICIs) and chemotherapy has been the standard first-line treatment for advanced non-small cell lung cancer (NSCLC) patients with driver-gene negative. However, e...

    Authors: Juan Zhou, Minwei Bao, Guanghui Gao, Yiran Cai, Lihong Wu, Lei Lei, Jing Zhao, Xianxiu Ji, Ying Huang and Chunxia Su
    Citation: BMC Medicine 2022 20:256
  10. Behavioral weight loss interventions are frequently hampered by long-term inefficacy. As metabolic improvements and health-related quality of life (HRQoL) are diminished by weight regain, effective long-term s...

    Authors: Linna Li, Dominik Soll, Verena Leupelt, Joachim Spranger and Knut Mai
    Citation: BMC Medicine 2022 20:238
  11. Neonatal sepsis can induce long-term cognitive impairment in adolescence or adulthood, but the underlying molecular mechanism is not fully understood. The expression of K+-Cl co-transporter 2 (KCC2) plays a pivo...

    Authors: Donghang Zhang, Yujiao Yang, Yaoxin Yang, Jin Liu, Tao Zhu, Han Huang and Cheng Zhou
    Citation: BMC Medicine 2022 20:235
  12. Prescription medications such as selective serotonin reuptake inhibitors (SSRIs), commonly used to treat depression, are associated with weight gain. The role of pharmacogenomics in predicting SSRI-induced wei...

    Authors: Maria L. Ricardo-Silgado, Sneha Singh, Lizeth Cifuentes, Paul A. Decker, Daniel Gonzalez-Izundegui, Ann M. Moyer, Maria D. Hurtado, Michael Camilleri, Suzette J. Bielinski and Andres Acosta
    Citation: BMC Medicine 2022 20:261
  13. Lipids play a vital role in health and disease, but changes to their circulating levels and the link with obesity remain poorly characterized in expecting mothers and their offspring in early childhood.

    Authors: Sartaj Ahmad Mir, Li Chen, Satvika Burugupalli, Bo Burla, Shanshan Ji, Adam Alexander T. Smith, Kothandaraman Narasimhan, Adaikalavan Ramasamy, Karen Mei-Ling Tan, Kevin Huynh, Corey Giles, Ding Mei, Gerard Wong, Fabian Yap, Kok Hian Tan, Fiona Collier…
    Citation: BMC Medicine 2022 20:242
  14. Intraductal carcinoma of the prostate (IDC-P) is a subtype of prostate cancer featured by poor prognosis. Previous studies suggested IDC-P could have a potentially unstable genome. Homologous recombination def...

    Authors: Sha Zhu, Jinge Zhao, Ling Nie, Wenlian Yin, Yaowen Zhang, Fengnian Zhao, Yuchao Ni, Xingming Zhang, Zhipeng Wang, Jindong Dai, Zhenhua Liu, Junru Chen, Yuhao Zeng, Zilin Wang, Guangxi Sun, Jiayu Liang…
    Citation: BMC Medicine 2022 20:237
  15. The protective effect of T cell-mediated immunity against influenza virus infections in natural settings remains unclear, especially in seasonal epidemics.

    Authors: Tim K. Tsang, Kwok-Tai Lam, Yinping Liu, Vicky J. Fang, Xiaofeng Mu, Nancy H. L. Leung, J. S. Malik Peiris, Gabriel M. Leung, Benjamin J. Cowling and Wenwei Tu
    Citation: BMC Medicine 2022 20:230
  16. Acute kidney injury (AKI) is common and associated with adverse outcomes as well as important healthcare costs. However, evidence examining the epidemiology of acute kidney disease (AKD)—recently defined as AK...

    Authors: Huan Wang, Emilie Lambourg, Bruce Guthrie, Daniel R. Morales, Peter T. Donnan and Samira Bell
    Citation: BMC Medicine 2022 20:229
  17. Multimorbidity is a rising global phenomenon, placing strains on countries’ population health and finances. This systematic review provides insight into the costs of multimorbidity through addressing the follo...

    Authors: Phuong Bich Tran, Joseph Kazibwe, Georgios F. Nikolaidis, Ismo Linnosmaa, Mieke Rijken and Josefien van Olmen
    Citation: BMC Medicine 2022 20:234
  18. At present, the extent and clinical relevance of epigenetic differences between upper tract urothelial carcinoma (UTUC) and urothelial carcinoma of the bladder (UCB) remain largely unknown. Here, we conducted ...

    Authors: Juan Li, Yuan Liang, Jian Fan, Chunru Xu, Bao Guan, Jianye Zhang, Bin Guo, Yue Shi, Ping Wang, Yezhen Tan, Qi Zhang, Changwei Yuan, Yucai Wu, Liqun Zhou, Weimin Ci and Xuesong Li
    Citation: BMC Medicine 2022 20:222
  19. Family history (FamH) of type 2 diabetes might indicate shared genotypes, environments, and/or behaviors. We hypothesize that FamH interacts with unhealthy behaviors to increase the risk of early onset of diab...

    Authors: Johnny T. K. Cheung, Eric Lau, Cyrus C. T. Tsui, Edmond L. N. Siu, Naomi K. W. Tse, Nicole Y. L. Hui, Ronald C. W. Ma, Alice P. S. Kong, Amy Fu, Vanessa Lau, Weiping Jia, Wayne H. H. Sheu, Leorino Sobrepena, K. H. Yoon, Alexander T. B. Tan, Yook-Chin Chia…
    Citation: BMC Medicine 2022 20:249
  20. Height is an important anthropometric measurement and is associated with many health-related outcomes. Genome-wide association studies (GWASs) have identified hundreds of genetic loci associated with height, m...

    Authors: Jian-Shiun Chiou, Chi-Fung Cheng, Wen-Miin Liang, Chen-Hsing Chou, Chung-Hsing Wang, Wei-De Lin, Mu-Lin Chiu, Wei-Chung Cheng, Cheng-Wen Lin, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Chang-Hai Tsai, Ying-Ju Lin and Fuu-Jen Tsai
    Citation: BMC Medicine 2022 20:250
  21. Homelessness has been associated with multiple detrimental health outcomes across observational studies. However, relatively few randomized controlled trials (RCTs) have been conducted on people who experience...

    Authors: Michele Fornaro, Elena Dragioti, Michele De Prisco, Martina Billeci, Anna Maria Mondin, Raffaella Calati, Lee Smith, Simon Hatcher, Mark Kaluzienski, Jess G. Fiedorowicz, Marco Solmi, Andrea de Bartolomeis and André F. Carvalho
    Citation: BMC Medicine 2022 20:224
  22. The FAST study identified claudin-18 (CLDN18.2) as a promising novel therapeutic target for gastric cancer (GC). However, the tumor immune microenvironment and clinicopathological features of CLDN18.2-positive...

    Authors: Keren Jia, Yang Chen, Yu Sun, Yajie Hu, Lei Jiao, Jie Ma, Jiajia Yuan, Changsong Qi, Yanyan Li, Jifang Gong, Jing Gao, Xiaotian Zhang, Jian Li, Cheng Zhang and Lin Shen
    Citation: BMC Medicine 2022 20:223
  23. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/1741-7015-10-40.

    Authors: Yingmei Zhang, Sara A. Babcock, Nan Hu, Jacalyn R. Maris, Haichang Wang and Jun Ren
    Citation: BMC Medicine 2022 20:248
  24. Umbrella clinical trials in precision oncology are designed to tailor therapies to the specific genetic changes within a tumor. Little is known about the risk/benefit ratio for umbrella clinical trials. The ai...

    Authors: Karolina Strzebonska, Mateusz Blukacz, Mateusz T. Wasylewski, Maciej Polak, Bishal Gyawali and Marcin Waligora
    Citation: BMC Medicine 2022 20:219
  25. Previous findings on the associations of thiazide use with skin cancers were conflicting. This study aimed to examine the associations of individual thiazide use with skin cancer risk, differentiated by subtyp...

    Authors: Shih-Chieh Shao, Chien-Cheng Lai, Yi-Hung Chen, Edward Chia-Cheng Lai, Ming-Jui Hung and Ching-Chi Chi
    Citation: BMC Medicine 2022 20:228
  26. Previous studies assessing the prevalence of COVID-19 sequelae in adults and children were performed in the absence of an agreed definition. We investigated prevalence of post-COVID-19 condition (PCC) (WHO def...

    Authors: Ekaterina Pazukhina, Margarita Andreeva, Ekaterina Spiridonova, Polina Bobkova, Anastasia Shikhaleva, Yasmin El-Taravi, Mikhail Rumyantsev, Aysylu Gamirova, Anastasiia Bairashevskaia, Polina Petrova, Dina Baimukhambetova, Maria Pikuza, Elina Abdeeva, Yulia Filippova, Salima Deunezhewa, Nikita Nekliudov…
    Citation: BMC Medicine 2022 20:244
  27. Recent publications reported a paradoxical finding that there was an inverse association between the number of standard modifiable risk factors (SMuRFs; smoking, hypertension, diabetes, and hyperlipidemia) and...

    Authors: Sidong Li, Xiaojin Gao, Jingang Yang, Haiyan Xu, Yang Wang, Yanyan Zhao, Lu Yin, Chao Wu, Yi Wang, Yang Zheng, Bao Li, Xuan Zhang, Yunqing Ye, Rui Fu, Qiuting Dong, Hui Sun…
    Citation: BMC Medicine 2022 20:217
  28. While the vaccines against COVID-19 are highly effective, COVID-19 vaccine breakthrough is possible despite being fully vaccinated. With SARS-CoV-2 variants still circulating, describing the characteristics of...

    Authors: Amelia Green, Helen Curtis, William Hulme, Elizabeth Williamson, Helen McDonald, Krishnan Bhaskaran, Christopher Rentsch, Anna Schultze, Brian MacKenna, Viyaasan Mahalingasivam, Laurie Tomlinson, Alex Walker, Louis Fisher, Jon Massey, Colm Andrews, Lisa Hopcroft…
    Citation: BMC Medicine 2022 20:243
  29. The American Heart Association recommends Life’s Simple 7 as ideal cardiovascular health (ICVH) to reduce cardiovascular risk. Rate advancement period (RAP), a useful tool to quantify and communicate exposure ...

    Authors: Cesar I. Fernandez-Lazaro, Carmen Sayon-Orea, Estefania Toledo, Conchi Moreno-Iribas and María J. Guembe
    Citation: BMC Medicine 2022 20:232
  30. Accumulating evidence now indicates that the presence of faecal haemoglobin, in the absence of gastrointestinal bleeding, may be an indicator of systemic inflammation and is linked to the development of human ...

    Authors: Choong-Kyun Noh, Eunyoung Lee, Bumhee Park and Sung Soo Ahn
    Citation: BMC Medicine 2022 20:226
  31. Cisplatin resistance is one of the main causes of treatment failure and death in head and neck squamous cell carcinoma (HNSCC). A more comprehensive understanding of the cisplatin resistance mechanism and the ...

    Authors: Tong Tong, Xing Qin, Yingying Jiang, Haiyan Guo, Xiaoning Wang, Yan Li, Fei Xie, Hao Lu, Peisong Zhai, Hailong Ma and Jianjun Zhang
    Citation: BMC Medicine 2022 20:231
  32. Placenta-derived proteins in the systemic maternal circulation are suggested as potential biomarkers for placental function. However, the identity and longitudinal patterns of such proteins are largely unknown...

    Authors: Maren-Helene Langeland Degnes, Ane Cecilie Westerberg, Manuela Zucknick, Theresa L. Powell, Thomas Jansson, Tore Henriksen, Marie Cecilie Paasche Roland and Trond Melbye Michelsen
    Citation: BMC Medicine 2022 20:227
  33. Acute kidney injury (AKI) and blackwater fever (BWF) are related but distinct renal complications of acute febrile illness in East Africa. The pathogenesis and prognostic significance of BWF and AKI are not we...

    Authors: Andrea L. Conroy, Michael T. Hawkes, Aleksandra Leligdowicz, Ivan Mufumba, Michelle C. Starr, Kathleen Zhong, Sophie Namasopo, Chandy C. John, Robert O. Opoka and Kevin C. Kain
    Citation: BMC Medicine 2022 20:221
  34. In 2013, a few years after the launch of the National Institute of Mental Health’s Research Domain Criteria (RDoC) initiative, Cuthbert and Insel published a paper titled “Toward the future of psychiatric diag...

    Authors: Sarah E. Morris, Charles A. Sanislow, Jenni Pacheco, Uma Vaidyanathan, Joshua A. Gordon and Bruce N. Cuthbert
    Citation: BMC Medicine 2022 20:220
  35. Although obesity has been associated with risk of atrial fibrillation (AF), the associations of variability of obesity measures with AF risk are uncertain, and longitudinal studies among Chinese population are...

    Authors: Maoxiang Zhao, Lulu Song, Qianqian Zhao, Yating Chen, Bin Li, Zhonghui Xie, Zihao Fu, Nan Zhang, Xiaowei Cheng, Xiaoqian Li, Miao Wang, Shouling Wu, Hao Xue and Yang Li
    Citation: BMC Medicine 2022 20:215
  36. The coronavirus disease 2019 (COVID-19) is a respiratory disease caused by SARS-CoV-2, a recently discovered strain of coronavirus. The virus has spread rapidly, causing millions of death worldwide. Contrary t...

    Authors: Tomabu Adjobimey, Julia Meyer, Vedrana Terkeš, Marijo Parcina and Achim Hoerauf
    Citation: BMC Medicine 2022 20:241
  37. Community pharmacies serve people with high levels of tobacco-related illness, but throughput in NHS Stop Smoking Services in pharmacies remains relatively low. We investigated the effectiveness of a complex i...

    Authors: Sandra Jumbe, Vichithranie W. Madurasinghe, Wai Yee James, Colin Houlihan, Samantha L. Jumbe, Tammy Yau, Florian Tomini, Sandra Eldridge, Borislava Mihaylova, Liz Steed, Ratna Sohanpal, Darush Attar, Stephanie J. C. Taylor, Chris Griffiths and Robert Walton
    Citation: BMC Medicine 2022 20:212
  38. The time of survival in patients with amyotrophic lateral sclerosis (ALS) varies greatly, and the genetic factors that contribute to the survival of ALS are not well studied. There is a lack of a comprehensive...

    Authors: Wei-Ming Su, Xiao-Jing Gu, Qing-Qing Duan, Zheng Jiang, Xia Gao, Hui-Fang Shang and Yong-Ping Chen
    Citation: BMC Medicine 2022 20:209
  39. Previous genome-wide association studies (GWAS) have identified numerous risk genes for lacunar stroke, but it is challenging to decipher how they confer risk for the disease. We employed an integrative analyt...

    Authors: Chengcheng Zhang, Fengqin Qin, Xiaojing Li, Xiangdong Du and Tao Li
    Citation: BMC Medicine 2022 20:211
  40. The current genome-wide association study (GWAS) of Lewy body dementia (LBD) suffers from low power due to a limited sample size. In addition, the genetic determinants underlying LBD and the shared genetic eti...

    Authors: Ping Guo, Weiming Gong, Yuanming Li, Lu Liu, Ran Yan, Yanjun Wang, Yanan Zhang and Zhongshang Yuan
    Citation: BMC Medicine 2022 20:214
  41. Preliminary evidence suggests that providing longer duration prescriptions at discharge may improve long-term adherence to secondary preventative cardiac medications among post-myocardial infarction (MI) patie...

    Authors: J. D. Schwalm, Noah M. Ivers, Zachary Bouck, Monica Taljaard, Madhu K. Natarajan, Francis Nguyen, Waseem Hijazi, Kednapa Thavorn, Lisa Dolovich, Tara McCready, Erin O’Brien and Jeremy M. Grimshaw
    Citation: BMC Medicine 2022 20:213
  42. We aimed to determine whether living in a household with children is associated with SARS-CoV-2 seropositivity in adults and investigated interacting factors that may influence this association.

    Authors: Jacob Blankenberger, Marco Kaufmann, Emiliano Albanese, Rebecca Amati, Daniela Anker, Anne-Linda Camerini, Patricia Chocano-Bedoya, Stéphane Cullati, Alexia Cusini, Jan Fehr, Erika Harju, Philipp Kohler, Susi Kriemler, Gisela Michel, Nicolas Rodondi, Pierre-Yves Rodondi…
    Citation: BMC Medicine 2022 20:233
  43. Recent guidelines recommended a systolic blood pressure (SBP) target of < 130 mmHg for patients with or without diabetes but without providing a lower bound. Our study aimed to explore whether additional clini...

    Authors: Chao Li, Kangyu Chen, Guoshuai Shi, Rui Shi, Zhenqiang Wu, Xiaodan Yuan, Vicky Watson, Zhixin Jiang, Hui Mai, Tian Yang, Duolao Wang and Tao Chen
    Citation: BMC Medicine 2022 20:208
  44. Osteoarthritis (OA) is a worldwide public health concern, mainly afflicting older adults. Although the etiology of OA remains unclear, environmental factors are increasingly considered as non-negligible risk f...

    Authors: Li Chen, Ying Zhao, Fangqu Liu, Huimin Chen, Tianqi Tan, Ping Yao and Yuhan Tang
    Citation: BMC Medicine 2022 20:207