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  1. Emerging findings highlighted the associations of mental illness to nutrition and dysbiosis in the intestinal microbiota, but the underlying mechanisms, especially in schizophrenia (SZ), remain unclarified.

    Authors: Ying Liang, Xing Shi, Yang Shen, Zhuoran Huang, Jian Wang, Changjun Shao, Yanan Chu, Jing Chen, Jun Yu and Yu Kang
    Citation: BMC Medicine 2022 20:67
  2. Dietary modifications are crucial for managing newly diagnosed type 2 diabetes mellitus (T2DM) and preventing its health complications, but many patients fail to achieve clinical goals with diet alone. We soug...

    Authors: Michal Rein, Orly Ben-Yacov, Anastasia Godneva, Smadar Shilo, Niv Zmora, Dmitry Kolobkov, Noa Cohen-Dolev, Bat-Chen Wolf, Noa Kosower, Maya Lotan-Pompan, Adina Weinberger, Zamir Halpern, Shira Zelber-Sagi, Eran Elinav and Eran Segal
    Citation: BMC Medicine 2022 20:56
  3. Metastatic cervical squamous cell carcinoma (CSCC) has poor prognosis and is recalcitrant to the current treatment strategies, which warrants the necessity to identify novel prognostic markers and therapeutic ...

    Authors: Yuanyuan Zhang, Ning Li, Guangwen Yuan, Hongwen Yao, Die Zhang, Nan Li, Gongyi Zhang, Yangchun Sun, Wenpeng Wang, Jia Zeng, Ningzhi Xu, Mei Liu and Lingying Wu
    Citation: BMC Medicine 2022 20:55
  4. selfBACK, an artificial intelligence (AI)-based app delivering evidence-based tailored self-management support to people with low back pain (LBP), has been shown to reduce LBP-related disability when added to usu...

    Authors: Cecilie K. Øverås, Tom I. L. Nilsen, Barbara I. Nicholl, Guy Rughani, Karen Wood, Karen Søgaard, Frances S. Mair and Jan Hartvigsen
    Citation: BMC Medicine 2022 20:53
  5. The evolution of SARS-CoV-2 has led to the emergence of several new variants, and few data are available on the impact of vaccination on SARS-CoV-2 variants. We aimed to assess the association between natural ...

    Authors: Giovanni Corrao, Matteo Franchi, Federico Rea, Danilo Cereda, Antonio Barone, Catia Rosanna Borriello, Petra Giulia Della Valle, Michele Ercolanoni, Ida Fortino, Jose Jara, Olivia Leoni, Francesco Mazziotta, Elisabetta Pierini, Giuseppe Preziosi, Marcello Tirani, Massimo Galli…
    Citation: BMC Medicine 2022 20:52
  6. DNA methylation-associated studies on biliary tract cancer (BTC), including cholangiocarcinoma (CCA) and gallbladder cancer (GBC), may improve the BTC classification scheme. We proposed to identify the shared ...

    Authors: Zhiquan Qiu, Jun Ji, Yu Xu, Yan Zhu, Chunfang Gao, Guoqiang Wang, Chengcheng Li, Yuzi Zhang, Jing Zhao, Chenyang Wang, Xiaofang Wen, Zhou Zhang, Bingsi Li, Zhihong Zhang, Shangli Cai, Bin Li…
    Citation: BMC Medicine 2022 20:64
  7. Cardiovascular and renal diseases (CVRD) are major causes of mortality in individuals with type 2 diabetes (T2D). Studies of lifetime risk have neither considered all CVRD together nor the relative contributio...

    Authors: Ruiqi Zhang, Jil Billy Mamza, Tamsin Morris, George Godfrey, Folkert W. Asselbergs, Spiros Denaxas, Harry Hemingway and Amitava Banerjee
    Citation: BMC Medicine 2022 20:63

    The Correction to this article has been published in BMC Medicine 2022 20:121

  8. Prostate-specific antigen (PSA) is a commonly used test to detect prostate cancer. Attention has mostly focused on the use of PSA in screening asymptomatic patients, but the diagnostic accuracy of PSA for pros...

    Authors: Samuel W. D. Merriel, Lucy Pocock, Emma Gilbert, Sam Creavin, Fiona M. Walter, Anne Spencer and Willie Hamilton
    Citation: BMC Medicine 2022 20:54
  9. The Kingdom of Saudi Arabia (KSA) quickly controlled the spread of SARS-CoV-2 by implementing several non-pharmaceutical interventions (NPIs), including suspension of international and national travel, local c...

    Authors: Donal Bisanzio, Richard Reithinger, Ada Alqunaibet, Sami Almudarra, Reem F. Alsukait, Di Dong, Yi Zhang, Sameh El-Saharty and Christopher H. Herbst
    Citation: BMC Medicine 2022 20:51
  10. A substantial portion of people with COVID-19 subsequently experience lasting symptoms including fatigue, shortness of breath, and neurological complaints such as cognitive dysfunction many months after acute ...

    Authors: Daniel Munblit, Timothy R. Nicholson, Dale M. Needham, Nina Seylanova, Callum Parr, Jessica Chen, Alisa Kokorina, Louise Sigfrid, Danilo Buonsenso, Shinjini Bhatnagar, Ramachandran Thiruvengadam, Ann M. Parker, Jacobus Preller, Sergey Avdeev, Frederikus A. Klok, Allison Tong…
    Citation: BMC Medicine 2022 20:50
  11. Fractures are a major health problem in aging societies. Preventive approaches combining bone health and fall prevention are rare. The osteoporotic fracture prevention program in rural areas (OFRA) is a health...

    Authors: Kilian Rapp, Sarah E. Lamb, Patrick Roigk, Clemens Becker, Claudia Konnopka, Hans-Helmut König, Raphael S. Peter, Dietrich Rothenbacher and Gisela Büchele
    Citation: BMC Medicine 2022 20:49
  12. Limitations to accessing delivery care services increase the risks of adverse outcomes during pregnancy and delivery for all pregnant women, particularly among adolescents in LMICs. In order to inform adolesce...

    Authors: Md. Mizanur Rahman, Hiroko Taniguchi, Raïssa Shiyghan Nsashiyi, Rashedul Islam, Syed Riaz Mahmud, Shafiur Rahman, Jenny Jung and Shahjahan Khan
    Citation: BMC Medicine 2022 20:46
  13. Previous observational studies suggested that a reduction in estimated glomerular filtration rate (eGFR) or a supranormal eGFR value was associated with adverse cardiovascular risks. However, a previous Mendel...

    Authors: Sehoon Park, Soojin Lee, Yaerim Kim, Semin Cho, Hyeok Huh, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim and Dong Ki Kim
    Citation: BMC Medicine 2022 20:44
  14. Evidence associating diet with the incidence of renal cell carcinoma (RCC) is inconclusive. We aimed to summarize evidence associating dietary factors with RCC incidence and assess the strength and validity of...

    Authors: Zhanchen Liao, Zhitao Fang, Siqi Gou, Yong Luo, Yiqi Liu, Zhun He, Xin Li, Yansong Peng, Zheng Fu, Dongjin Li, Haiyun Chen and Zhigang Luo
    Citation: BMC Medicine 2022 20:39
  15. Studies have reported an increased risk of mortality among people prescribed mirtazapine compared to other antidepressants. The study aimed to compare all-cause and cause-specific mortality between adults pres...

    Authors: Rebecca M. Joseph, Ruth H. Jack, Richard Morriss, Roger David Knaggs, Debbie Butler, Chris Hollis, Julia Hippisley-Cox and Carol Coupland
    Citation: BMC Medicine 2022 20:43
  16. We aimed to map and describe the current state of Mendelian randomization (MR) literature on cancer risk and to identify associations supported by robust evidence.

    Authors: Georgios Markozannes, Afroditi Kanellopoulou, Olympia Dimopoulou, Dimitrios Kosmidis, Xiaomeng Zhang, Lijuan Wang, Evropi Theodoratou, Dipender Gill, Stephen Burgess and Konstantinos K. Tsilidis
    Citation: BMC Medicine 2022 20:41
  17. Donepezil, galantamine, rivastigmine and memantine are potentially effective interventions for cognitive impairment in dementia, but the use of these drugs has not been personalised to individual patients yet....

    Authors: Qiang Liu, Nemanja Vaci, Ivan Koychev, Andrey Kormilitzin, Zhenpeng Li, Andrea Cipriani and Alejo Nevado-Holgado
    Citation: BMC Medicine 2022 20:45
  18. There is currently a lack of effective treatments for non-small cell lung cancer (NSCLC) patients harboring HER2 mutations. We examined the efficacy and safety of, and potential resistance mechanism to, pyrotinib...

    Authors: Zhengbo Song, Yuping Li, Shiqing Chen, Shenpeng Ying, Shuguang Xu, Jianjin Huang, Dan Wu, Dongqing Lv, Ting Bei, Shuxun Liu, Xiaoping Huang, Congying Xie, Xiaoyu Wu, Jianfei Fu, Feng Hua, Wenxian Wang…
    Citation: BMC Medicine 2022 20:42
  19. Greater maternal adiposity before or during pregnancy is associated with greater offspring adiposity throughout childhood, but the extent to which this is due to causal intrauterine or periconceptional mechani...

    Authors: Tom A. Bond, Rebecca C. Richmond, Ville Karhunen, Gabriel Cuellar-Partida, Maria Carolina Borges, Verena Zuber, Alexessander Couto Alves, Dan Mason, Tiffany C. Yang, Marc J. Gunter, Abbas Dehghan, Ioanna Tzoulaki, Sylvain Sebert, David M. Evans, Alex M. Lewin, Paul F. O’Reilly…
    Citation: BMC Medicine 2022 20:34
  20. Cabazitaxel improves overall survival (OS) in metastatic castration-resistant prostate cancer (mCRPC) patients progressing after docetaxel. In this prospective study, we evaluated the prognostic role of CTC ge...

    Authors: Giorgia Gurioli, Vincenza Conteduca, Nicole Brighi, Emanuela Scarpi, Umberto Basso, Giuseppe Fornarini, Alessandra Mosca, Maurizio Nicodemo, Giuseppe Luigi Banna, Cristian Lolli, Giuseppe Schepisi, Giorgia Ravaglia, Isabella Bondi, Paola Ulivi and Ugo De Giorgi
    Citation: BMC Medicine 2022 20:48
  21. Human papilloma virus infection is known to influence oropharyngeal cancer (OPC) risk, likely via sexual transmission. However, sexual behaviour has been correlated with other risk factors including smoking an...

    Authors: Mark Gormley, Tom Dudding, Linda Kachuri, Kimberley Burrows, Amanda H. W. Chong, Richard M. Martin, Steven J. Thomas, Jessica Tyrrell, Andrew R. Ness, Paul Brennan, Marcus R. Munafò, Miranda Pring, Stefania Boccia, Andrew F. Olshan, Brenda Diergaarde, Rayjean J. Hung…
    Citation: BMC Medicine 2022 20:40
  22. To allow a return to a pre-COVID-19 lifestyle, virtually every country has initiated a vaccination program to mitigate severe disease burden and control transmission. However, it remains to be seen whether her...

    Authors: Hengcong Liu, Juanjuan Zhang, Jun Cai, Xiaowei Deng, Cheng Peng, Xinghui Chen, Juan Yang, Qianhui Wu, Xinhua Chen, Zhiyuan Chen, Wen Zheng, Cécile Viboud, Wenhong Zhang, Marco Ajelli and Hongjie Yu
    Citation: BMC Medicine 2022 20:37
  23. Metabolic syndrome (MetS) is a risk factor in surgery. MetS can progress to metabolic (dysfunction)-associated fatty liver disease (MAFLD), a vast-growing etiology of primary liver tumors which are major indic...

    Authors: Anastasia Murtha-Lemekhova, Juri Fuchs, Svenja Feiler, Erik Schulz, Miriam Teroerde, Eva Kalkum, Rosa Klotz, Adrian Billeter, Pascal Probst and Katrin Hoffmann
    Citation: BMC Medicine 2022 20:47
  24. Emerging evidence supports an association between vaginal microbiota composition and risk of miscarriage; however, the underlying mechanisms are poorly understood. We aim to investigate the vaginal microbial c...

    Authors: Karen Grewal, Yun S. Lee, Ann Smith, Jan J. Brosens, Tom Bourne, Maya Al-Memar, Samit Kundu, David A. MacIntyre and Phillip R. Bennett
    Citation: BMC Medicine 2022 20:38
  25. Evidence on vaccine-specific protection over time, in particular against the Delta variant, and protection afforded by a homologous third dose is urgently needed.

    Authors: Xinhua Chen, Wei Wang, Xinghui Chen, Qianhui Wu, Ruijia Sun, Shijia Ge, Nan Zheng, Wanying Lu, Juan Yang, Lance Rodewald and Hongjie Yu
    Citation: BMC Medicine 2022 20:36
  26. The development of the human placenta is tightly coordinated by a multitude of placental cell types, including human chorionic villi mesenchymal stromal cells (hCV-MSCs). Defective hCV-MSCs have been reported ...

    Authors: Sophia Indira Romberg, Nina-Naomi Kreis, Alexandra Friemel, Susanne Roth, Alice Steglich Souto, Samira Catharina Hoock, Kyra Fischer, Thorsten Nowak, Christine Solbach, Frank Louwen, Andreas Ritter and Juping Yuan
    Citation: BMC Medicine 2022 20:35
  27. Understanding the age patterns of disease is necessary to target interventions to maximise cost-effective impact. New malaria chemoprevention and vaccine initiatives target young children attending routine imm...

    Authors: Alice Kamau, Robert S. Paton, Samuel Akech, Arthur Mpimbaza, Cynthia Khazenzi, Morris Ogero, Eda Mumo, Victor A. Alegana, Ambrose Agweyu, Neema Mturi, Shebe Mohammed, Godfrey Bigogo, Allan Audi, James Kapisi, Asadu Sserwanga, Jane F. Namuganga…
    Citation: BMC Medicine 2022 20:28
  28. The prevalence of overweight and obesity is increasing among African children potentially predisposing them to greater obesity and non-communicable diseases (NCDs) in adulthood. This risk may be higher among g...

    Authors: Kurt Z. Long, Johanna Beckmann, Christin Lang, Harald Seelig, Siphesihle Nqweniso, Nicole Probst-Hensch, Ivan Müller, Uwe Pühse, Peter Steinmann, Rosa du Randt, Cheryl Walter, Jürg Utzinger and Markus Gerber
    Citation: BMC Medicine 2022 20:27
  29. Clinical trials have demonstrated that initiating oral anti-diabetic drugs (OADs) significantly reduce glycated hemoglobin (HbA1c) levels. However, variability in lifestyle modifications and OAD adherence impa...

    Authors: Hao Sen Andrew Fang, Qiao Gao, Wei Ying Tan, Mong Li Lee, Wynne Hsu and Ngiap Chuan Tan
    Citation: BMC Medicine 2022 20:22
  30. Heart failure with preserved ejection fraction (HFpEF) is the dominant form of heart failure (HF). We here aimed to investigate the characteristics and prognosis of HFpEF in patients with hypertrophic cardiomy...

    Authors: Jie Liu, Dong Wang, Jieyun Ruan, Guixin Wu, Lianjun Xu, Wen Jiang, Jizheng Wang, Xiaolu Sun, Lianming Kang and Lei Song
    Citation: BMC Medicine 2022 20:21
  31. Protection from severe disease and hospitalization by SARS-CoV-2 vaccination has been amply demonstrated by real-world data. However, the rapidly evolving pandemic raises new concerns. One pertains efficacy of...

    Authors: Rahul Ukey, Natalie Bruiners, Hridesh Mishra, Pankaj K. Mishra, Deborah McCloskey, Alberta Onyuka, Fei Chen, Abraham Pinter, Daniela Weiskopf, Alessandro Sette, Jason Roy, Sunanda Gaur and Maria Laura Gennaro
    Citation: BMC Medicine 2022 20:32
  32. Telomere length (TL) and its attrition are important indicators of physiological stress and biological aging and hence may vary among individuals of the same age. This variation is apparent even in newborns, s...

    Authors: Li Chen, Karen Mei Ling Tan, Min Gong, Mary F. F. Chong, Kok Hian Tan, Yap Seng Chong, Michael J. Meaney, Peter D. Gluckman, Johan G. Eriksson and Neerja Karnani
    Citation: BMC Medicine 2022 20:20
  33. Hypertensive disorders of pregnancy are common pregnancy complications that are associated with greater cardiovascular disease risk for mothers. However, risk of cardiovascular disease subtypes associated with...

    Authors: Clare Oliver-Williams, David Stevens, Rupert A. Payne, Ian B. Wilkinson, Gordon C. S. Smith and Angela Wood
    Citation: BMC Medicine 2022 20:19
  34. Alanine aminotransferase (ALT) levels are widely used to screen liver disease, and many asymptomatic individuals show elevated ALT levels. As elevated ALT level indicates liver injury, even a small amount of a...

    Authors: Dong Hyun Sinn, Danbee Kang, Eliseo Guallar, Yun Soo Hong, Juhee Cho and Geum-Youn Gwak
    Citation: BMC Medicine 2022 20:18
  35. The humoral immune response after primary immunisation with a SARS-CoV-2 vector vaccine (AstraZeneca AZD1222, ChAdOx1 nCoV-19, Vaxzevria) followed by an mRNA vaccine boost (Pfizer/BioNTech, BNT162b2; Moderna, ...

    Authors: Ruben Rose, Franziska Neumann, Olaf Grobe, Thomas Lorentz, Helmut Fickenscher and Andi Krumbholz
    Citation: BMC Medicine 2022 20:31
  36. With the recent certification by World Health Organization that the People’s Republic of China is malaria-free, it is timely to consider how elimination of malaria was completed in People’s Republic of China o...

    Authors: Guo-Jing Yang, Le-Yuan Shang, Xiao-Nong Zhou, Tamsin E. Lee, Bo Bi, Michael White, Thomas A. Smith and Melissa A. Penny
    Citation: BMC Medicine 2022 20:17
  37. Surgical resection followed by chemo-radiation postpones glioblastoma (GBM) progression and extends patient survival, but these tumours eventually recur. Multimodal treatment plans combining intraoperative tec...

    Authors: Justyna Mączyńska, Florian Raes, Chiara Da Pieve, Stephen Turnock, Jessica K. R. Boult, Julia Hoebart, Marcin Niedbala, Simon P. Robinson, Kevin J. Harrington, Wojciech Kaspera and Gabriela Kramer-Marek
    Citation: BMC Medicine 2022 20:16

    The Correction to this article has been published in BMC Medicine 2022 20:179

  38. Heart failure (HF) is increasingly prevalent in the growing elderly population and commonly associated with cognitive impairment. We compared trends in place of death (PoD) of HF patients with/without comorbid...

    Authors: James M. Beattie, Irene J. Higginson, Theresa A. McDonagh and Wei Gao
    Citation: BMC Medicine 2022 20:30
  39. COVID-19 is an infectious disease characterized by multiple respiratory and extrapulmonary manifestations, including gastrointestinal symptoms. Although recent studies have linked gut microbiota to infectious ...

    Authors: Zhonghan Sun, Zhi-Gang Song, Chenglin Liu, Shishang Tan, Shuchun Lin, Jiajun Zhu, Fa-Hui Dai, Jian Gao, Jia-Lei She, Zhendong Mei, Tao Lou, Jiao-Jiao Zheng, Yi Liu, Jiang He, Yuanting Zheng, Chen Ding…
    Citation: BMC Medicine 2022 20:24
  40. Sex influences outcome of patients with acute coronary syndrome (ACS). If there is a relationship between sex and physical performance is unknown.

    Authors: Elisabetta Tonet, Albert Ariza-Solé, Matteo Serenelli, Francesc Formiga, Juan Sanchis, Rita Pavasini, Pablo Diez-Villanueva, Francesco Vitali, Clara Bonanad, Giovanni Grazzi, Antoni Carol, Giorgio Chiaranda, Graziella Pompei, Laura Sofia Cardelli, Serena Caglioni, Federico Gibiino…
    Citation: BMC Medicine 2022 20:15
  41. While vaccination programs against the severe acute respiratory syndrome virus 2 (SARS-CoV-2) are globally ongoing, disparate strategies for the deployment of spike antigen show varying effectiveness.

    Authors: Michael Müller, Johann Volzke, Behnam Subin, Silke Müller, Martina Sombetzki, Emil C. Reisinger and Brigitte Müller-Hilke
    Citation: BMC Medicine 2022 20:29
  42. Chronic kidney disease (CKD) is associated with increased propensity for arrhythmias. In this context, ventricular repolarization alterations have been shown to predispose to fatal arrhythmias and sudden cardi...

    Authors: José Alberto Navarro-García, Rafael Salguero-Bodes, Laura González-Lafuente, Laura Martín-Nunes, Elena Rodríguez-Sánchez, Teresa Bada-Bosch, Eduardo Hernández, Evangelina Mérida-Herrero, Manuel Praga, Jorge Solís, Fernando Arribas, Héctor Bueno, Makoto Kuro-O, María Fernández-Velasco, Luis Miguel Ruilope, Carmen Delgado…
    Citation: BMC Medicine 2022 20:14
  43. Recaticimab (SHR-1209, a humanized monoclonal antibody against PCSK9) showed robust LDL-C reduction in healthy volunteers. This study aimed to further assess the efficacy and safety of recaticimab in patients ...

    Authors: Mingtong Xu, Xiaoxue Zhu, Junyan Wu, Yuling Zhang, Dong Zhao, Xuhong Wang, Yanhua Ding, Yu Cao, Chengqian Li, Wei Hu, Jianlong Sheng, Zhu Luo, Zeqi Zheng, Jinfang Hu, Jianying Liu, Xiaoyang Zhou…
    Citation: BMC Medicine 2022 20:13
  44. Central nervous system (CNS) metastases in patients with ALK-positive non-small cell lung cancer (NSCLC) are a cause of substantial morbidity and mortality. Although alectinib had demonstrated promising intrac...

    Authors: Zihua Zou, Puyuan Xing, Xuezhi Hao, Yan Wang, Xia Song, Li Shan, Cuiying Zhang, Ziling Liu, Kewei Ma, Guilan Dong and Junling Li
    Citation: BMC Medicine 2022 20:12
  45. There is considerable variability in disease progression for patients with amyotrophic lateral sclerosis (ALS) including the age of disease onset, site of disease onset, and survival time. There is growing evi...

    Authors: Frances Theunissen, Loren L. Flynn, Ryan S. Anderton and P. Anthony Akkari
    Citation: BMC Medicine 2022 20:11
  46. Nudging is increasingly used to promote healthy food choices in supermarkets. Ordering groceries online is gaining in popularity and nudging seems efficacious there as well, but is never comprehensively tested...

    Authors: Josine M. Stuber, Jeroen Lakerveld, Loes W. Kievitsbosch, Joreintje D. Mackenbach and Joline W. J. Beulens
    Citation: BMC Medicine 2022 20:10
  47. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious respiratory virus which is responsible for the coronavirus disease 2019 (COVID-19) pandemic. It is increasingly clear that re...

    Authors: Feargal J. Ryan, Christopher M. Hope, Makutiro G. Masavuli, Miriam A. Lynn, Zelalem A. Mekonnen, Arthur Eng Lip Yeow, Pablo Garcia-Valtanen, Zahraa Al-Delfi, Jason Gummow, Catherine Ferguson, Stephanie O’Connor, Benjamin A. J. Reddi, Pravin Hissaria, David Shaw, Chuan Kok-Lim, Jonathan M. Gleadle…
    Citation: BMC Medicine 2022 20:26
  48. Mother-to-baby transmission of group B Streptococcus (GBS) is the main cause of early-onset infection. We evaluated whether, in women with clinical risk factors for early neonatal infection, the use of point-of-c...

    Authors: Jane P. Daniels, Emily Dixon, Alicia Gill, Jon Bishop, Mark Wilks, Michael Millar, Jim Gray, Tracy E. Roberts, Jane Plumb, Jonathan J. Deeks, Karla Hemming, Khalid S. Khan and Shakila Thangaratinam
    Citation: BMC Medicine 2022 20:9
  49. Aberrant DNA methylation may offer opportunities in revolutionizing cancer screening and diagnosis. We sought to identify a non-invasive DNA methylation-based screening approach using cell-free DNA (cfDNA) for...

    Authors: Biyuan Luo, Fang Ma, Hao Liu, Jixiong Hu, Le Rao, Chun Liu, Yongfang Jiang, Shuyu Kuangzeng, Xuan Lin, Chenyang Wang, Yiyu Lei, Zhongzhou Si, Guangshun Chen, Ning Zhou, Chengbai Liang, Fangqing Jiang…
    Citation: BMC Medicine 2022 20:8