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  1. The current guidelines for survivorship in adolescents and young adults (AYA) cancer are based on studies conducted in the United States and European AYA survivors. However, previous studies have shown that th...

    Authors: Sooyeon Kim, Juhee Cho, Dong Wook Shin, Su-Min Jeong and Danbee Kang
    Citation: BMC Medicine 2023 21:289
  2. India had an estimated 2.9 million tuberculosis cases and 506 thousand deaths in 2021. Novel vaccines effective in adolescents and adults could reduce this burden. M72/AS01E and BCG-revaccination have recently co...

    Authors: Rebecca A. Clark, Chathika K. Weerasuriya, Allison Portnoy, Christinah Mukandavire, Matthew Quaife, Roel Bakker, Danny Scarponi, Rebecca C. Harris, Kirankumar Rade, Sanjay Kumar Mattoo, Dheeraj Tumu, Nicolas A. Menzies and Richard G. White
    Citation: BMC Medicine 2023 21:288
  3. Microglia are known to regulate stress and anxiety in both humans and animal models. Psychosocial stress is the most common risk factor for the development of schizophrenia. However, how microglia/brain macrop...

    Authors: Ling Yan, Yanli Li, Fengmei Fan, Mengzhuang Gou, Fangling Xuan, Wei Feng, Keerthana Chithanathan, Wei Li, Junchao Huang, Hongna Li, Wenjin Chen, Baopeng Tian, Zhiren Wang, Shuping Tan, Alexander Zharkovsky, L. Elliot Hong…
    Citation: BMC Medicine 2023 21:286
  4. Psoriasis and atopic eczema are common inflammatory skin diseases. Existing research has identified increased risks of common mental disorders (anxiety, depression) in people with eczema and psoriasis; however...

    Authors: Alasdair D. Henderson, Elizabeth Adesanya, Amy Mulick, Julian Matthewman, Nhung Vu, Firoza Davies, Catherine H. Smith, Joseph Hayes, Kathryn E. Mansfield and Sinéad M. Langan
    Citation: BMC Medicine 2023 21:285
  5. Tinnitus affects 10 to 15% of the population, but its underlying causes are not yet fully understood. Hearing loss has been established as the most important risk factor. Ageing is also known to accompany incr...

    Authors: Lisa Reisinger, Fabian Schmidt, Kaja Benz, Lorenzo Vignali, Sebastian Roesch, Martin Kronbichler and Nathan Weisz
    Citation: BMC Medicine 2023 21:283
  6. Self-harm is an important predictor of a suicide death. Culturally appropriate strategies for the prevention of self-harm and suicide are needed but the evidence is very limited from low- and middle-income cou...

    Authors: Nusrat Husain, Tayyeba Kiran, Imran Bashir Chaudhry, Christopher Williams, Richard Emsley, Usman Arshad, Moin Ahmed Ansari, Paul Bassett, Penny Bee, Moti Ram Bhatia, Carolyn Chew-Graham, Muhammad Omair Husain, Muhammad Irfan, Ayesha Khaliq, Fareed A. Minhas, Farooq Naeem…
    Citation: BMC Medicine 2023 21:282
  7. The EAT-Lancet Commission proposed a global reference diet with both human health benefits and environmental sustainability in 2019. However, evidence regarding the association of such a diet with the risk of ...

    Authors: Shunming Zhang, Anna Stubbendorff, Ulrika Ericson, Per Wändell, Kaijun Niu, Lu Qi, Yan Borné and Emily Sonestedt
    Citation: BMC Medicine 2023 21:280
  8. HCV self-testing (HCVST) may be an effective strategy to address low rates of HCV test uptake among men who have sex with men (MSM). We evaluated the effectiveness and cost of providing HCVST to increase HCV t...

    Authors: Cheng Wang, Peizhen Zhao, Ann Marie Weideman, Wenqian Xu, Jason J. Ong, Muhammad S. Jamil, Bin Yang and Joseph D. Tucker
    Citation: BMC Medicine 2023 21:279
  9. Meat-free diets may be associated with a higher risk of hip fracture, but prospective evidence is limited. We aimed to investigate the risk of hip fracture in occasional meat-eaters, pescatarians, and vegetari...

    Authors: James Webster, Darren C. Greenwood and Janet E. Cade
    Citation: BMC Medicine 2023 21:278
  10. China has one of the highest numbers of liver disease cases in the world, including 6.4 million cirrhosis associated with alcohol-related liver disease (ALD) cases. However, there is still a lack of urgent awa...

    Authors: Meiyu Wu, Shuxia Qin, Chongqing Tan, Sini Li, Ouyang Xie and Xiaomin Wan
    Citation: BMC Medicine 2023 21:277
  11. Homozygous familial hypercholesterolemia (HoFH) is an orphan metabolic disease characterized by extremely elevated low-density lipoprotein cholesterol (LDL-C), xanthomas, aortic stenosis, and premature atheros...

    Authors: Zhiyong Du, Fan Li, Long Jiang, Linyi Li, Yunhui Du, Huahui Yu, Yan Luo, Yu Wang, Haili Sun, Chaowei Hu, Jianping Li, Ya Yang, Xiaolu Jiao, Luya Wang and Yanwen Qin
    Citation: BMC Medicine 2023 21:275
  12. Persistent infection by oncogenic human papillomavirus (HPV) is necessary although not sufficient for development of cervical cancer. Behavioural, environmental, or comorbid exposures may promote or protect ag...

    Authors: Sarah J. Bowden, Triada Doulgeraki, Emmanouil Bouras, Georgios Markozannes, Antonios Athanasiou, Harriet Grout-Smith, Konstantinos S. Kechagias, Laura Burney Ellis, Verena Zuber, Marc Chadeau-Hyam, James M. Flanagan, Konstantinos K. Tsilidis, Ilkka Kalliala and Maria Kyrgiou
    Citation: BMC Medicine 2023 21:274
  13. In the dynamic landscape of respiratory virus vaccines, it is crucial to assess the value of novel mRNA and combination influenza/COVID-19 vaccines in low- and middle-income countries. Modeling studies, such a...

    Authors: K. E. Lafond, R. Gharpure, V. G. Dugan and E. Azziz-Baumgartner
    Citation: BMC Medicine 2023 21:273

    The Correspondence to this article has been published in BMC Medicine 2023 21:301

    The original article was published in BMC Medicine 2023 21:106

  14. Coffee is the most widely consumed psychostimulant worldwide. Emerging evidence indicates that coffee consumption habit significantly reduces the risk of developing Parkinson’s disease (PD). However, the effec...

    Authors: Chao Wang, Cheng Zhou, Tao Guo, Yeerfan Jiaerken, Siyu Yang, Xiaopei Xu, Ling Hu, Peiyu Huang, Xiaojun Xu and Minming Zhang
    Citation: BMC Medicine 2023 21:272
  15. Stroke is a major cause of mortality and long-term disability worldwide. Whether the associations between brain imaging-derived phenotypes (IDPs) and stroke are causal is uncertain.

    Authors: Ke Yu, Xiao-Feng Chen, Jing Guo, Sen Wang, Xiao-Ting Huang, Yan Guo, Shan-Shan Dong and Tie-Lin Yang
    Citation: BMC Medicine 2023 21:271
  16. The introduction of multiparameter MRI and novel biomarkers has greatly improved the prediction of clinically significant prostate cancer (csPCa). However, decision-making regarding prostate biopsy and prebiop...

    Authors: Huiyong Zhang, Jin Ji, Zhe Liu, Huiru Lu, Chong Qian, Chunmeng Wei, Shaohua Chen, Wenhao Lu, Chengbang Wang, Huan Xu, Yalong Xu, Xi Chen, Xing He, Zuheng Wang, Xiaodong Zhao, Wen Cheng…
    Citation: BMC Medicine 2023 21:270
  17. Chronic disease management (CDM) through sustained knowledge translation (KT) interventions ensures long-term, high-quality care. We assessed implementation of KT interventions for supporting CDM and their eff...

    Authors: Areti Angeliki Veroniki, Charlene Soobiah, Vera Nincic, Yonda Lai, Patricia Rios, Heather MacDonald, Paul A. Khan, Marco Ghassemi, Fatemeh Yazdi, Ross C. Brownson, David A. Chambers, Lisa R. Dolovich, Annemarie Edwards, Paul P. Glasziou, Ian D. Graham, Brenda R. Hemmelgarn…
    Citation: BMC Medicine 2023 21:269

    The Commentary to this article has been published in BMC Medicine 2023 21:325

  18. Tumour-infiltrating lymphocytes (TILs), including T and B cells, have been demonstrated to be associated with tumour progression. However, the different subpopulations of TILs and their roles in breast cancer ...

    Authors: Zi-An Xia, Can Lu, Can Pan, Jia Li, Jun Li, Yitao Mao, Lunquan Sun and Jiang He
    Citation: BMC Medicine 2023 21:268
  19. Comorbidities are expected to impact the pathophysiology of heart failure (HF) with preserved ejection fraction (HFpEF). However, comorbidity profiles are usually reduced to a few comorbid disorders. Systems m...

    Authors: Jan D. Lanzer, Alberto Valdeolivas, Mark Pepin, Hauke Hund, Johannes Backs, Norbert Frey, Hans-Christoph Friederich, Jobst-Hendrik Schultz, Julio Saez-Rodriguez and Rebecca T. Levinson
    Citation: BMC Medicine 2023 21:267
  20. Increasing evidence suggests an association between pro-inflammatory diets and cognitive function. However, only a few studies based on small sample sizes have explored the association between pro-inflammatory...

    Authors: Yisen Shi, Fabin Lin, Yueping Li, Yingqing Wang, Xiaochun Chen, Fangang Meng, Qinyong Ye and Guoen Cai
    Citation: BMC Medicine 2023 21:266
  21. Prehabilitation aims at enhancing patients’ functional capacity and overall health status to enable them to withstand a forthcoming stressor like surgery. Our aim was to synthesise the evidence on the cost-eff...

    Authors: Tanja Rombey, Helene Eckhardt, Jörn Kiselev, Julia Silzle, Tim Mathes and Wilm Quentin
    Citation: BMC Medicine 2023 21:265
  22. Since the coronavirus disease 2019 (COVID-19) outbreak, many COVID-19 variants have emerged, causing several waves of pandemics and many infections. Long COVID-19, or long-term sequelae after recovery from COV...

    Authors: Deyu Zhang, Siyuan Weng, Chuanchao Xia, Yuqing Ren, Zaoqu Liu, Yudi Xu, Xiaoli Yang, Ruhao Wu, Lisi Peng, Liqi Sun, Jiaqi Zhu, Xuesong Liang, Yin Jia, Huaizhou Wang, Qian Chen, Dongtian Liu…
    Citation: BMC Medicine 2023 21:264
  23. It remains a challenge to predict the long-term response to antipsychotics in patients with schizophrenia who do not respond at an early stage. This study aimed to investigate the optimal predictive cut-off va...

    Authors: Yujun Long, Qiongqiong Wu, Ye Yang, Jingda Cai, Jingmei Xiao, Zhaoqian Liu, Yifeng Xu, Ying Chen, Manli Huang, Ruiguo Zhang, Xijia Xu, Jian Hu, Zhifen Liu, Fang Liu, Yingjun Zheng, Huaqing Meng…
    Citation: BMC Medicine 2023 21:263
  24. Probiotics are often used to prevent antibiotic-induced low-diversity dysbiosis, however their effect is not yet sufficiently summarized in this regard. We aimed to investigate the effects of concurrent probio...

    Authors: Anna Júlia Éliás, Viktória Barna, Cristina Patoni, Dóra Demeter, Dániel Sándor Veres, Stefania Bunduc, Bálint Erőss, Péter Hegyi, László Földvári-Nagy and Katalin Lenti
    Citation: BMC Medicine 2023 21:262
  25. Previous studies have found a correlation between coronavirus disease 2019 (COVID-19) and changes in brain structure and cognitive function, but it remains unclear whether COVID-19 causes brain structural chan...

    Authors: Shaojiong Zhou, Tao Wei, Xiaoduo Liu, Yufei Liu, Weiyi Song, Xinwei Que, Yi Xing, Zhibin Wang and Yi Tang
    Citation: BMC Medicine 2023 21:261
  26. Gestational diabetes mellitus (GDM) is associated with both short- and long-term risks, although it is unknown if risks vary by severity, timing, and duration of gestational hyperglycemia. We aimed to identify...

    Authors: Shuyun Chen, Margareta Persson, Rui Wang, Christina Dalman, Brian K. Lee, Håkan Karlsson and Renee M. Gardner
    Citation: BMC Medicine 2023 21:260
  27. To determine the extent and nature of changes associated with COVID-19 infection in terms of healthcare utilisation, this study observed healthcare contact 1 to 4 and 5 to 24 weeks following a COVID-19 diagnos...

    Authors: J Kennedy, M Parker, M Seaborne, M Mhereeg, A Walker, V Walker, S Denaxas, N Kennedy, S. V Katikireddi and S Brophy
    Citation: BMC Medicine 2023 21:259
  28. Preterm birth (PTB), defined as delivery before 37 gestational weeks, imposes significant public health burdens. A recent maternal genome-wide association study of spontaneous PTB identified a noncoding locus ...

    Authors: Li Wang, Robert M. Rossi, Xiaoting Chen, Jing Chen, Jilian Runyon, Mehak Chawla, Daniel Miller, Carmy Forney, Arthur Lynch, Xuzhe Zhang, Fansheng Kong, Bo Jacobsson, Leah C. Kottyan, Matthew T. Weirauch, Ge Zhang and Louis J. Muglia
    Citation: BMC Medicine 2023 21:258
  29. Valvular heart disease (VHD) can cause damage to extra-cardiac organs, and lead to multi-organ dysfunction. However, little is known about the cardio-renal-hepatic co-dysfunction, as well as its prognostic imp...

    Authors: Junxing Lv, Bin Zhang, Yunqing Ye, Zhe Li, Weiwei Wang, Qinghao Zhao, Qingrong Liu, Zhenyan Zhao, Haitong Zhang, Bincheng Wang, Zikai Yu, Zhenya Duan, Shuai Guo, Yanyan Zhao, Runlin Gao, Haiyan Xu…
    Citation: BMC Medicine 2023 21:257
  30. Genome-wide association studies (GWAS) have reported single-nucleotide polymorphisms (SNPs) in the VRK serine/threonine kinase 2 gene (VRK2) showing genome-wide significant associations with major depression, but...

    Authors: Mei-Yu Yin, Lei Guo, Li-Juan Zhao, Chen Zhang, Wei-Peng Liu, Chu-Yi Zhang, Jin-Hua Huo, Lu Wang, Shi-Wu Li, Chang-Bo Zheng, Xiao Xiao, Ming Li, Chuang Wang and Hong Chang
    Citation: BMC Medicine 2023 21:256
  31. The feasibility of DNA methylation-based assays in detecting minimal residual disease (MRD) and postoperative monitoring remains unestablished. We aim to investigate the dynamic characteristics of cancer-relat...

    Authors: Kezhong Chen, Guannan Kang, Zhihong Zhang, Analyn Lizaso, Stephan Beck, Iben Lyskjær, Olga Chervova, Bingsi Li, Haifeng Shen, Chenyang Wang, Bing Li, Heng Zhao, Xi Li, Fan Yang, Nnennaya Kanu and Jun Wang
    Citation: BMC Medicine 2023 21:255
  32. Schizophrenia and bipolar disorder (BD) are believed to share clinical symptoms, genetic risk, etiological factors, and pathogenic mechanisms. We previously reported that single nucleotide polymorphisms spanni...

    Authors: Zhi-Hui Yang, Xin Cai, Zhong-Li Ding, Wei Li, Chu-Yi Zhang, Jin-Hua Huo, Yue Zhang, Lu Wang, Lin-Ming Zhang, Shi-Wu Li, Ming Li, Chen Zhang, Hong Chang and Xiao Xiao
    Citation: BMC Medicine 2023 21:254
  33. PARP inhibitor (PARPi), as a kind of DNA damage repair inhibitor, has been shown to be effective in various solid tumors and hematologic malignancies. Natural killer/T cell lymphoma (NKTCL) is a highly aggress...

    Authors: Jiazhuo Wu, Cunzhen Shi, Hongwen Li, Wenting Song, Shuo Huang, Jianxiang Zhang, Wencai Li, Zhaoming Li and Mingzhi Zhang
    Citation: BMC Medicine 2023 21:253
  34. Calcific aortic valve disease (CAVD) is the most prevalent valvular disease and has high morbidity and mortality. CAVD is characterized by complex pathophysiological processes, including inflammation-induced o...

    Authors: Shunyi Li, Zichao Luo, Shuwen Su, Liming Wen, Gaopeng Xian, Jing Zhao, Xingbo Xu, Dingli Xu and Qingchun Zeng
    Citation: BMC Medicine 2023 21:252
  35. Cannabis consumption by pregnant women continues to increase worldwide, raising concerns about adverse effects on fetal growth and deleterious impacts on the newborn, in connection with evidence of placental t...

    Authors: J. Dochez-Arnault, C. Desdoits-Lethimonier, I. Matias, B. Evrard, M. Lagarrigue, M. Toupin, A. Lardenois, F. Chalmel, S. Mazaud-Guittot, N. Dejucq-Rainsford and A. Gely-Pernot
    Citation: BMC Medicine 2023 21:219
  36. A dietary pattern (DP) may impact on cancer incidence more strongly than individual foods, but this association remains uncertain. Here, we aimed to broadly explore the associations of an obesity-related DP wi...

    Authors: Maiwulamujiang Maimaitiyiming, Hongxi Yang, Lihui Zhou, Xinyu Zhang, Qiliang Cai and Yaogang Wang
    Citation: BMC Medicine 2023 21:251
  37. Inflammation has been implicated in the pathology of schizophrenia and may cause neuronal cell death and dendrite loss. Neuroimaging studies have highlighted longitudinal brain structural changes in patients w...

    Authors: Long-Biao Cui, Xian-Yang Wang, Yu-Fei Fu, Xiao-Fan Liu, Yongbin Wei, Shu-Wan Zhao, Yue-Wen Gu, Jing-Wen Fan, Wen-Jun Wu, Hengfen Gong, Bochao Danae Lin, Hong Yin, Fanglin Guan and Xiao Chang
    Citation: BMC Medicine 2023 21:250
  38. This study aimed to determine whether primary parathyroid cancer patients were associated with increased metabolic and cardiovascular comorbidities in comparison to the general population.

    Authors: Ming-Chieh Tsai, Min-Shu Hsu, Hsin-Yin Hsu, Tzu-Lin Yeh, Chun-Ju Chiang, Wen-Chung Lee, Jing-Rong Jhuang, Shih-Ping Cheng, Po-Jung Tseng and Kuo-Liong Chien
    Citation: BMC Medicine 2023 21:249
  39. The COVID-19 Vaccine Introduction and deployment Costing (CVIC) tool was developed to assist countries to estimate incremental financial costs to roll out COVID-19 vaccines. This article describes the purposes...

    Authors: Karene Hoi Ting Yeung, Eunkyoung Kim, Wei Aun Yap, Chansay Pathammavong, Lauren Franzel, Yu Lee Park, Peter Cowley, Ulla Kou Griffiths and Raymond Christiaan W. Hutubessy
    Citation: BMC Medicine 2023 21:248
  40. Providing informal care for a person with Parkinson’s disease (PD) can be a demanding process affecting several dimensions of a caregiver’s life and potentially causing caregiver burden. Despite the emerging l...

    Authors: Angelika D. Geerlings, Willanka M. Kapelle, Charlotte J. Sederel, Emma Tenison, Hilde Wijngaards-Berenbroek, Marjan J. Meinders, Marten Munneke, Yoav Ben-Shlomo, Bastiaan R. Bloem and Sirwan K. L. Darweesh
    Citation: BMC Medicine 2023 21:247
  41. Early phase dose-finding (EPDF) trials are crucial for the development of a new intervention and influence whether it should be investigated in further trials. Guidance exists for clinical trial protocols and ...

    Authors: Olga Solovyeva, Munyaradzi Dimairo, Christopher J. Weir, Siew Wan Hee, Aude Espinasse, Moreno Ursino, Dhrusti Patel, Andrew Kightley, Sarah Hughes, Thomas Jaki, Adrian Mander, Thomas R. Jeffry Evans, Shing Lee, Sally Hopewell, Khadija Rerhou Rantell, An-Wen Chan…
    Citation: BMC Medicine 2023 21:246
  42. Due to the asymptomatic nature of the early stages, chronic kidney disease (CKD) is usually diagnosed at late stages and lacks targeted therapy, highlighting the need for new biomarkers to better understand it...

    Authors: Jie-sheng Lin, Jana Nano, Agnese Petrera, Stefanie M. Hauck, Tanja Zeller, Wolfgang Koenig, Christian L. Müller, Annette Peters and Barbara Thorand
    Citation: BMC Medicine 2023 21:245
  43. Vaping cessation is virtually unexplored. The efficacy and safety of varenicline for vaping cessation has not been studied and rigorous research is required to advance best practice and outcomes for people who...

    Authors: Pasquale Caponnetto, Davide Campagna, Jasjit S. Ahluwalia, Christopher Russell, Marilena Maglia, Paolo Marco Riela, Carmelo Fabio Longo, Barbara Busa and Riccardo Polosa
    Citation: BMC Medicine 2023 21:220
  44. Randomised controlled trials are often beset by problems with poor recruitment and retention. Information to support decisions on trial participation is usually provided as printed participant information shee...

    Authors: Peter Knapp, Thirimon Moe-Byrne, Jacqueline Martin-Kerry, Rebecca Sheridan, Jenny Roche, Elizabeth Coleman, Peter Bower, Steven Higgins, Catherine Stones, Jonathan Graffy, Jenny Preston, Carrol Gamble, Bridget Young, Daniel Perry, Annegret Dahlmann-Noor, Mohamed Abbas…
    Citation: BMC Medicine 2023 21:244
  45. Elimination of mother-to-child transmission of hepatitis B virus (HBV) requires infant immunoprophylaxis and antiviral prophylaxis for pregnant women with high viral loads. Since real-time polymerase chain rea...

    Authors: Yasir Shitu Isa, Jonathan Sicsic, Henry Njuguna, John Ward, Mohamed Chakroun, Mohamed El-Kassas, Rado Ramanampamonjy, Salim Chalal, Jeanne Perpétue Vincent, Monique Andersson, Hailemichael Desalegn, Fatou Fall, Asgeir Johannessen, Philippa C. Matthews, Gibril Ndow, Edith Okeke…
    Citation: BMC Medicine 2023 21:243
  46. Several economic obstacles can deter the development and use of vaccines. This can lead to limited product options for some diseases, delays in new product development, and inequitable access to vaccines. Alth...

    Authors: Raymond Hutubessy, Jeremy A. Lauer, Birgitte Giersing, So Yoon Sim, Mark Jit, David Kaslow and Siobhan Botwright
    Citation: BMC Medicine 2023 21:229