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  1. A critical and challenging process in immunotherapy is to identify cancer patients who could benefit from immune checkpoint inhibitors (ICIs). Exploration of predictive biomarkers could help to maximize the cl...

    Authors: Zhen Zhang, Hao-Xiang Wu, Wu-Hao Lin, Zi-Xian Wang, Lu-Ping Yang, Zhao-Lei Zeng and Hui-Yan Luo

    Citation: BMC Medicine 2021 19:26

    Content type: Research article

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  2. Although there are many clinical and molecular biomarkers in acute myeloid leukemia (AML), the novel and reliable biomarkers are still required to predict the overall survival at the time of disease diagnosis.

    Authors: Jinghan Wang, Jiajia Pan, Shujuan Huang, Fenglin Li, Jiansong Huang, Xia Li, Qing Ling, Wenle Ye, Yungui Wang, Wenjuan Yu and Jie Jin

    Citation: BMC Medicine 2021 19:28

    Content type: Research article

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  3. SARS-CoV-2 has induced a worldwide pandemic and subsequent non-pharmaceutical interventions (NPIs) to control the spread of the virus. As in many countries, the SARS-CoV-2 pandemic in Germany has led to a cons...

    Authors: Sahamoddin Khailaie, Tanmay Mitra, Arnab Bandyopadhyay, Marta Schips, Pietro Mascheroni, Patrizio Vanella, Berit Lange, Sebastian C. Binder and Michael Meyer-Hermann

    Citation: BMC Medicine 2021 19:32

    Content type: Research article

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  4. Sex hormones have been suggested to play a role in colorectal cancer (CRC), but their influence on early initiation of CRC remains unknown.

    Authors: Dong Hang, Xiaosheng He, Ane Sørlie Kværner, Andrew T. Chan, Kana Wu, Shuji Ogino, Zhibin Hu, Hongbing Shen, Edward L. Giovannucci and Mingyang Song

    Citation: BMC Medicine 2021 19:18

    Content type: Research article

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  5. Prognostic models developed in general cohorts with a mixture of heart failure (HF) phenotypes, though more widely applicable, are also likely to yield larger prediction errors in settings where the HF phenoty...

    Authors: Yuntao Chen, Adriaan A. Voors, Tiny Jaarsma, Chim C. Lang, Iziah E. Sama, K. Martijn Akkerhuis, Eric Boersma, Hans L. Hillege and Douwe Postmus

    Citation: BMC Medicine 2021 19:21

    Content type: Research article

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  6. Studies systematically screening medications have successfully identified prescription medicines associated with cancer risk. However, adjustment for confounding factors in these studies has been limited. We t...

    Authors: R. D. McDowell, C. Hughes, P. Murchie and C. Cardwell

    Citation: BMC Medicine 2021 19:22

    Content type: Research article

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  7. The World Health Organization (WHO) in 2015 stated that every effort should be made to provide cesarean delivery (CD) for women in need. In China, the two-child policy largely prompts the number of advanced ag...

    Authors: Ci Song, Yan Xu, Yuqing Ding, Yanfang Zhang, Na Liu, Lin Li, Zhun Li, Jiangbo Du, Hua You, Hongxia Ma, Guangfu Jin, Xudong Wang, Hongbing Shen, Yuan Lin, Xiaoqing Jiang and Zhibin Hu

    Citation: BMC Medicine 2021 19:14

    Content type: Research article

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  8. The National Early Warning Score (NEWS2) is currently recommended in the UK for the risk stratification of COVID-19 patients, but little is known about its ability to detect severe cases. We aimed to evaluate ...

    Authors: Ewan Carr, Rebecca Bendayan, Daniel Bean, Matt Stammers, Wenjuan Wang, Huayu Zhang, Thomas Searle, Zeljko Kraljevic, Anthony Shek, Hang T. T. Phan, Walter Muruet, Rishi K. Gupta, Anthony J. Shinton, Mike Wyatt, Ting Shi, Xin Zhang…

    Citation: BMC Medicine 2021 19:23

    Content type: Research article

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  9. In utero exposure to Zika virus (ZIKV) is known to be associated with birth defects. The impact of in utero ZIKV exposure on neurodevelopmental outcomes in early childhood remains unclear. The objective of thi...

    Authors: Rebecca Grant, Olivier Fléchelles, Benoît Tressières, Mama Dialo, Narcisse Elenga, Nicolas Mediamolle, Adeline Mallard, Jean-Christophe Hebert, Noémie Lachaume, Elvire Couchy, Bruno Hoen and Arnaud Fontanet

    Citation: BMC Medicine 2021 19:12

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2021 19:41

  10. Much progress has been made in mapping genetic abnormalities linked to amyotrophic lateral sclerosis (ALS), but the majority of cases still present with no known underlying cause. Furthermore, even in families...

    Authors: Sarah L. Boddy, Ilaria Giovannelli, Matilde Sassani, Johnathan Cooper-Knock, Michael P. Snyder, Eran Segal, Eran Elinav, Lynne A. Barker, Pamela J. Shaw and Christopher J. McDermott

    Citation: BMC Medicine 2021 19:13

    Content type: Review

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  11. It has been well established that the TMEM106B gene rs1990622 variant was a frontotemporal dementia (FTD) risk factor. Until recently, growing evidence highlights the role of TMEM106B in Alzheimer’s disease (AD)....

    Authors: Yang Hu, Jing-yi Sun, Yan Zhang, Haihua Zhang, Shan Gao, Tao Wang, Zhifa Han, Longcai Wang, Bao-liang Sun and Guiyou Liu

    Citation: BMC Medicine 2021 19:11

    Content type: Research article

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  12. Comorbidities affect outcomes in heart failure (HF), but are not reflected in current HF classification. The aim of this study is to characterize HF groups that account for higher-order interactions between co...

    Authors: Claudia Gulea, Rosita Zakeri and Jennifer K. Quint

    Citation: BMC Medicine 2021 19:9

    Content type: Research article

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  13. Malnutrition continues to affect under-five children in Africa to an overwhelming proportion. The situation is further compounded by the burden of sickle cell disease (SCD). However, association of SCD with st...

    Authors: Mohammad Redwanul Islam, Md Moinuddin, Ayeda Ahmed and Syed Moshfiqur Rahman

    Citation: BMC Medicine 2021 19:5

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2021 19:17

  14. A high body mass index (BMI) has been associated with increased risk of several cancers; however, whether BMI is related to a larger number of cancers than currently recognized is unclear. Moreover, whether wa...

    Authors: Martina Recalde, Veronica Davila-Batista, Yesika Díaz, Michael Leitzmann, Isabelle Romieu, Heinz Freisling and Talita Duarte-Salles

    Citation: BMC Medicine 2021 19:10

    Content type: Research article

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  15. The etiologies of chronic neurological diseases, which heavily contribute to global disease burden, remain far from elucidated. Despite available umbrella reviews on single contributing factors or diseases, no...

    Authors: Alexios-Fotios A. Mentis, Efthimios Dardiotis, Vasiliki Efthymiou and George P. Chrousos

    Citation: BMC Medicine 2021 19:6

    Content type: Research article

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  16. Cross-reactivity to SARS-CoV-2 from exposure to endemic human coronaviruses (eHCoV) is gaining increasing attention as a possible driver of both protection against infection and COVID-19 severity. Here we expl...

    Authors: Francesco Pinotti, Paul S. Wikramaratna, Uri Obolski, Robert S. Paton, Daniel S. C. Damineli, Luiz C. J. Alcantara, Marta Giovanetti, Sunetra Gupta and José Lourenço

    Citation: BMC Medicine 2021 19:19

    Content type: Research article

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  17. Alcohol consumption is a leading contributor to death and disability worldwide, but previous research has not examined the effects of different patterns of alcohol consumption. The study objective was to under...

    Authors: Bhautesh Dinesh Jani, Ross McQueenie, Barbara I. Nicholl, Ryan Field, Peter Hanlon, Katie I. Gallacher, Frances S. Mair and Jim Lewsey

    Citation: BMC Medicine 2021 19:8

    Content type: Research article

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  18. Adiposity is a strong risk factor for cancer incidence and mortality. However, most of the evidence available has focused on body mass index (BMI) as a marker of adiposity. There is limited evidence on relatio...

    Authors: Solange Parra-Soto, Emma S. Cowley, Leandro F. M. Rezende, Catterina Ferreccio, John C. Mathers, Jill P. Pell, Frederick K. Ho and Carlos Celis-Morales

    Citation: BMC Medicine 2021 19:7

    Content type: Research article

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  19. Medical costs and the burden associated with cardiovascular disease are on the rise. Therefore, to improve the overall economy and quality assessment of the healthcare system, we developed a predictive model o...

    Authors: Tomoyuki Takura, Keiko Hirano Goto and Asao Honda

    Citation: BMC Medicine 2021 19:15

    Content type: Research article

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  20. The optimal distribution between physical activity (PA) levels and sedentary behaviour (SB) for the greatest benefits for body composition among older adults with overweight/obesity and chronic health conditio...

    Authors: Aina M. Galmes-Panades, Jadwiga Konieczna, Veronica Varela-Mato, Itziar Abete, Nancy Babio, Miquel Fiol, José Antonio de Paz, Rosa Casas, Romina Olbeyra, Miguel Ruiz-Canela, Antoni Palau-Galindo, Olga Castañer, Arturo Martín-García, Ramón Estruch, Josep Vidal, Pilar Buil-Cosiales…

    Citation: BMC Medicine 2021 19:3

    Content type: Research article

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  21. Nutrition and lifestyle have been long established as risk factors for colorectal cancer (CRC). Modifiable lifestyle behaviours bear potential to minimize long-term CRC risk; however, translation of lifestyle ...

    Authors: Krasimira Aleksandrova, Robin Reichmann, Rudolf Kaaks, Mazda Jenab, H. Bas Bueno-de-Mesquita, Christina C. Dahm, Anne Kirstine Eriksen, Anne Tjønneland, Fanny Artaud, Marie-Christine Boutron-Ruault, Gianluca Severi, Anika Hüsing, Antonia Trichopoulou, Anna Karakatsani, Eleni Peppa, Salvatore Panico…

    Citation: BMC Medicine 2021 19:1

    Content type: Research article

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  22. Atrial fibrillation (AF) is common in older people with frailty and is associated with an increased risk of stroke and systemic embolism. Whilst oral anticoagulation is associated with a reduction in this risk...

    Authors: Chris Wilkinson, Jianhua Wu, Samuel D. Searle, Oliver Todd, Marlous Hall, Vijay Kunadian, Andrew Clegg, Kenneth Rockwood and Chris P. Gale

    Citation: BMC Medicine 2020 18:401

    Content type: Research article

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  23. Fetal growth restriction (FGR) due to placental insufficiency is a major risk factor for stillbirth. While small-for-gestational-age (SGA; weight < 10th centile) is a commonly used proxy for FGR, detection of ...

    Authors: Lucy M. Kennedy, Stephen Tong, Alice J. Robinson, Richard J. Hiscock, Lisa Hui, Kirsten M. Dane, Anna L. Middleton, Susan P. Walker and Teresa M. MacDonald

    Citation: BMC Medicine 2020 18:395

    Content type: Research article

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  24. Major depressive disorder (MDD) shows large heterogeneity of symptoms between patients, but within patients, particular symptom clusters may show similar trajectories. While symptom clusters and networks have ...

    Authors: K. Hebbrecht, M. Stuivenga, T. Birkenhäger, M. Morrens, E. I. Fried, B. Sabbe and E. J. Giltay

    Citation: BMC Medicine 2020 18:400

    Content type: Research article

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  25. In pregnancy lipid levels increase with gestation resembling an atherogenic lipid profile. Currently it is unclear whether gestational lipid levels are associated with an adverse cardiovascular risk profile la...

    Authors: Maria C. Adank, Laura Benschop, Sophia P. van Streun, Anna M. Smak Gregoor, Monique T. Mulder, Eric A. P. Steegers, Sarah Schalekamp-Timmermans and Jeanine E. Roeters van Lennep

    Citation: BMC Medicine 2020 18:394

    Content type: Research article

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  26. Colposcopy diagnosis and directed biopsy are the key components in cervical cancer screening programs. However, their performance is limited by the requirement for experienced colposcopists. This study aimed t...

    Authors: Peng Xue, Chao Tang, Qing Li, Yuexiang Li, Yu Shen, Yuqian Zhao, Jiawei Chen, Jianrong Wu, Longyu Li, Wei Wang, Yucong Li, Xiaoli Cui, Shaokai Zhang, Wenhua Zhang, Xun Zhang, Kai Ma…

    Citation: BMC Medicine 2020 18:406

    Content type: Research article

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  27. Silent cerebral infarcts (SCIs) are the most common neurological complication in children and adults with sickle cell disease (SCD). In this systematic review, we provide an overview of studies that have detec...

    Authors: Maite E. Houwing, Rowena L. Grohssteiner, Marjolein H. G. Dremmen, Ferdows Atiq, Wichor M. Bramer, Anne P. J. de Pagter, C. Michel Zwaan, Tonya J. H. White, Meike W. Vernooij and Marjon H. Cnossen

    Citation: BMC Medicine 2020 18:393

    Content type: Research article

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  28. The objectives of this study are to determine the effects of regularly scheduled administration of paracetamol (acetaminophen) on quality of life (QoL), discomfort, pain and neuropsychiatric symptoms of person...

    Authors: Paulien H. van Dam, Wilco P. Achterberg, Bettina S. Husebo and Monique A. A. Caljouw

    Citation: BMC Medicine 2020 18:407

    Content type: Research article

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  29. Oral rehydration solution (ORS) is a simple intervention that can prevent childhood deaths from severe diarrhea and dehydration. In a previous study, we mapped the use of ORS treatment subnationally and found ...

    Authors: Kirsten E. Wiens, Lauren E. Schaeffer, Samba O. Sow, Babacar Ndoye, Carrie Jo Cain, Mathew M. Baumann, Kimberly B. Johnson, Paulina A. Lindstedt, Brigette F. Blacker, Zulfiqar A. Bhutta, Natalie M. Cormier, Farah Daoud, Lucas Earl, Tamer Farag, Ibrahim A. Khalil, Damaris K. Kinyoki…

    Citation: BMC Medicine 2020 18:405

    Content type: Research article

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  30. The COVID-19 pandemic has placed significant pressure on health and social care. Survivors of COVID-19 may be left with substantial functional deficits requiring ongoing care. We aimed to determine whether pre...

    Authors: A. Vilches-Moraga, A. Price, P. Braude, L. Pearce, R. Short, A. Verduri, M. Stechman, J. T. Collins, E. Mitchell, A. G. Einarsson, S. J. Moug, T. J. Quinn, B. Stubbs, K. McCarthy, P. K. Myint, J. Hewitt…

    Citation: BMC Medicine 2020 18:408

    Content type: Research article

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  31. The COVID-19 pandemic has placed sustained demand on health systems globally, and the capacity to provide critical care has been overwhelmed in some jurisdictions. It is unknown which triage criteria for alloc...

    Authors: Kirsten M. Fiest, Karla D. Krewulak, Kara M. Plotnikoff, Laryssa G. Kemp, Ken Kuljit S. Parhar, Daniel J. Niven, John B. Kortbeek, Henry T. Stelfox and Jeanna Parsons Leigh

    Citation: BMC Medicine 2020 18:404

    Content type: Research article

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  32. Due to the overlapping clinical features of coronavirus disease 2019 (COVID-19) and influenza, parallels are often drawn between the two diseases. Patients with pre-existing cardiovascular diseases (CVD) are a...

    Authors: Muhammad Shahzeb Khan, Izza Shahid, Stefan D. Anker, Scott D. Solomon, Orly Vardeny, Erin D. Michos, Gregg C. Fonarow and Javed Butler

    Citation: BMC Medicine 2020 18:403

    Content type: Review

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  33. The increasing use of preprints to disseminate evidence on the effect of interventions for the coronavirus disease 2019 (COVID-19) can lead to multiple evidence sources for a single study, which may differ in ...

    Authors: Theodora Oikonomidi, Isabelle Boutron, Olivier Pierre, Guillaume Cabanac and Philippe Ravaud

    Citation: BMC Medicine 2020 18:402

    Content type: Research article

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  34. Zika virus (ZIKV) emerged as a global epidemic in 2015–2016 from Latin America with its true geographical extent remaining unclear due to widely presumed underreporting. The identification of locations with po...

    Authors: Haoyang Sun, Borame L. Dickens, Mark Jit, Alex R. Cook and L. Roman Carrasco

    Citation: BMC Medicine 2020 18:399

    Content type: Research article

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  35. Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or by sex is unclear. Further, the metabolic alterations mediating the effects of adi...

    Authors: Caroline J. Bull, Joshua A. Bell, Neil Murphy, Eleanor Sanderson, George Davey Smith, Nicholas J. Timpson, Barbara L. Banbury, Demetrius Albanes, Sonja I. Berndt, Stéphane Bézieau, D. Timothy Bishop, Hermann Brenner, Daniel D. Buchanan, Andrea Burnett-Hartman, Graham Casey, Sergi Castellví-Bel…

    Citation: BMC Medicine 2020 18:396

    Content type: Research article

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  36. Dementia is caused by a variety of neurodegenerative diseases and is associated with a decline in memory and other cognitive abilities, while inflicting an enormous socioeconomic burden. The complexity of deme...

    Authors: KongFatt Wong-Lin, Paula L. McClean, Niamh McCombe, Daman Kaur, Jose M. Sanchez-Bornot, Paddy Gillespie, Stephen Todd, David P. Finn, Alok Joshi, Joseph Kane and Bernadette McGuinness

    Citation: BMC Medicine 2020 18:398

    Content type: Review

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  37. Cholera epidemics continue to challenge disease control, particularly in fragile and conflict-affected states. Rapid detection and response to small cholera clusters is key for efficient control before an epid...

    Authors: Ruwan Ratnayake, Flavio Finger, W. John Edmunds and Francesco Checchi

    Citation: BMC Medicine 2020 18:397

    Content type: Research article

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  38. The proportion of infections among young children that are antimicrobial-resistant is increasing across the globe. Newborns may be colonized with enteric antimicrobial-resistant pathogens early in life, which ...

    Authors: Maya L. Nadimpalli, Claire D. Bourke, Ruairi C. Robertson, Elisabeth Delarocque-Astagneau, Amee R. Manges and Amy J. Pickering

    Citation: BMC Medicine 2020 18:392

    Content type: Opinion

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  39. Clinical decision-making of invasive high-intensity care for critically ill stage IV cancer patients in the emergency department (ED) is challenging. A reliable and clinically available prognostic score for ad...

    Authors: Youn-Jung Kim, Jihoon Kang, Min-Ju Kim, Seung Mok Ryoo, Gu Hyun Kang, Tae Gun Shin, Yoo Seok Park, Sung-Hyuk Choi, Woon Yong Kwon, Sung Phil Chung and Won Young Kim

    Citation: BMC Medicine 2020 18:390

    Content type: Research article

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  40. HIV is known to increase the likelihood of reactivation of latent tuberculosis to active TB disease; however, its impact on tuberculosis infectiousness and consequent transmission is unclear, particularly in l...

    Authors: Joanne R. Winter, Colette J. Smith, Jennifer A. Davidson, Maeve K. Lalor, Valerie Delpech, Ibrahim Abubakar and Helen R. Stagg

    Citation: BMC Medicine 2020 18:385

    Content type: Research article

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  41. Polycystic ovary syndrome (PCOS) is challenging to diagnose. While the 2003 Rotterdam criteria are widely used for adults, the 2018 international PCOS guideline recommended updated Rotterdam criteria with both...

    Authors: Chau Thien Tay, Roger J. Hart, Martha Hickey, Lisa J. Moran, Arul Earnest, Dorota A. Doherty, Helena J. Teede and Anju E. Joham

    Citation: BMC Medicine 2020 18:389

    Content type: Research article

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  42. Valid cause of death data are essential for health policy formation. The quality of medical certification of cause of death (MCCOD) by physicians directly affects the utility of cause of death data for public ...

    Authors: U. S. H. Gamage, Pasyodun Koralage Buddhika Mahesh, Jesse Schnall, Lene Mikkelsen, John D. Hart, Hafiz Chowdhury, Hang Li, Deirdre McLaughlin and Alan D. Lopez

    Citation: BMC Medicine 2020 18:384

    Content type: Research article

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  43. Methylmalonic acid (MMA) is best known for its use as a functional marker of vitamin B12 deficiency. However, MMA concentrations not only depend on adequate vitamin B12 status, but also relate to renal functio...

    Authors: Ineke J. Riphagen, Isidor Minović, Dion Groothof, Adrian Post, Manfred L. Eggersdorfer, Jenny E. Kootstra-Ros, Martin H. de Borst, Gerjan Navis, Frits A. J. Muskiet, Ido P. Kema, M. Rebecca Heiner-Fokkema and Stephan J. L. Bakker

    Citation: BMC Medicine 2020 18:380

    Content type: Research article

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