Wang-Sattler R, Yu Y, Mittelstrass K, Lattka E, Altmaier E, Gieger C, Ladwig KH, Dahmen N, Weinberger KM, Hao P, Liu L, Li Y, Wichmann H-E, Adamski J, Suhre K, Illig T: Metabolic profiling reveals distinct variations linked to nicotine consumption in humans--first results from the KORA study. PLoS One. 2008, 3: e3863-10.1371/journal.pone.0003863.
Article
PubMed
PubMed Central
Google Scholar
Xavier F, Henn L de A, Oliveira M, Orlandine L: Smoking and its relation to the histological type, survival, and prognosis among patients with primary lung cancer. Sao Paulo Med J. 1996, 114: 1298-1302.
Article
CAS
PubMed
Google Scholar
Smoking-attributable mortality, years of potential life lost, and productivity losses--United States, 2000-2004. Morbidity and Mortality Weekly Report. 2008, 57: 1226-1228.
Bøttcher M, Falk E: Pathology of the coronary arteries in smokers and non-smokers. J Cardiovasc Risk. 1999, 6: 299-302.
Article
PubMed
Google Scholar
Howard G, Burke GL, Szklo M, Tell GS, Eckfeldt J, Evans G, Heiss G: Active and passive smoking are associated with increased carotid wall thickness. The Atherosclerosis Risk in Communities Study. Arch Intern Med. 1994, 154: 1277-1282. 10.1001/archinte.1994.00420110125014.
Article
CAS
PubMed
Google Scholar
Libby P: Inflammation in atherosclerosis. Nature. 2002, 420: 868-874. 10.1038/nature01323.
Article
CAS
PubMed
Google Scholar
Szmitko PE, Wang C-H, Weisel RD, Jeffries GA, Anderson TJ, Verma S: Biomarkers of vascular disease linking inflammation to endothelial activation: Part II. Circulation. 2003, 108: 2041-2048. 10.1161/01.CIR.0000089093.75585.98.
Article
PubMed
Google Scholar
Danesh J, Whincup P, Walker M, Lennon L, Thomson A, Appleby P, Gallimore JR, Pepys MB: Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses. BMJ. 2000, 321: 199-204. 10.1136/bmj.321.7255.199.
Article
CAS
PubMed
PubMed Central
Google Scholar
Danesh J, Muir J, Wong YK, Ward M, Gallimore JR, Pepys MB: Risk factors for coronary heart disease and acute-phase proteins. A population-based study. Eur Heart J. 1999, 20: 954-959. 10.1053/euhj.1998.1309.
Article
CAS
PubMed
Google Scholar
Rigotti NA, Pasternak RC: Cigarette smoking and coronary heart disease: risks and management. Cardiol Clin. 1996, 14: 51-68. 10.1016/S0733-8651(05)70260-5.
Article
CAS
PubMed
Google Scholar
Cook DG, Shaper AG, Pocock SJ, Kussick SJ: Giving up smoking and the risk of heart attacks. A report from The British Regional Heart Study. Lancet. 1986, 2: 1376-1380.
Article
CAS
PubMed
Google Scholar
Aberg A, Bergstrand R, Johansson S, Ulvenstam G, Vedin A, Wedel H, Wilhelmsson C, Wilhelmsen L: Cessation of smoking after myocardial infarction. Effects on mortality after 10 years. Br Heart J. 1983, 49: 416-422. 10.1136/hrt.49.5.416.
Article
CAS
PubMed
PubMed Central
Google Scholar
Halpern MT, Gillespie BW, Warner KE: Patterns of absolute risk of lung cancer mortality in former smokers. J Natl Cancer Inst. 1993, 85: 457-464. 10.1093/jnci/85.6.457.
Article
CAS
PubMed
Google Scholar
Ebbert JO, Yang P, Vachon CM, Vierkant RA, Cerhan JR, Folsom AR, Sellers TA: Lung cancer risk reduction after smoking cessation: observations from a prospective cohort of women. J Clin Oncol. 2003, 21: 921-926. 10.1200/JCO.2003.05.085.
Article
CAS
PubMed
Google Scholar
Bakhru A, Erlinger TP: Smoking cessation and cardiovascular disease risk factors: results from the Third National Health and Nutrition Examination Survey. PLoS Med. 2005, 2: e160-10.1371/journal.pmed.0020160.
Article
PubMed
PubMed Central
Google Scholar
De Maat MP, Pietersma A, Kofflard M, Sluiter W, Kluft C: Association of plasma fibrinogen levels with coronary artery disease, smoking and inflammatory markers. Atherosclerosis. 1996, 121: 185-191. 10.1016/0021-9150(95)05716-1.
Article
CAS
PubMed
Google Scholar
Pradhan AD, Manson JE, Rossouw JE, Siscovick DS, Mouton CP, Rifai N, Wallace RB, Jackson RD, Pettinger MB, Ridker PM: Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: prospective analysis from the Women's Health Initiative observational study. JAMA. 2002, 288: 980-987. 10.1001/jama.288.8.980.
Article
CAS
PubMed
Google Scholar
Yanbaeva DG, Dentener MA, Creutzberg EC, Wesseling G, Wouters EFM: Systemic effects of smoking. Chest. 2007, 131: 1557-1566. 10.1378/chest.06-2179.
Article
CAS
PubMed
Google Scholar
Powell CA, Klares S, O'Connor G, Brody JS: Loss of heterozygosity in epithelial cells obtained by bronchial brushing: clinical utility in lung cancer. Clin Cancer Res. 1999, 5: 2025-2034.
CAS
PubMed
Google Scholar
Wistuba II, Lam S, Behrens C, Virmani AK, Fong KM, LeRiche J, Samet JM, Srivastava S, Minna JD, Gazdar AF: Molecular damage in the bronchial epithelium of current and former smokers. J Natl Cancer Inst. 1997, 89: 1366-1373. 10.1093/jnci/89.18.1366.
Article
CAS
PubMed
Google Scholar
Wistuba II, Mao L, Gazdar AF: Smoking molecular damage in bronchial epithelium. Oncogene. 2002, 21: 7298-7306. 10.1038/sj.onc.1205806.
Article
CAS
PubMed
Google Scholar
Guo M, House MG, Hooker C, Han Y, Heath E, Gabrielson E, Yang SC, Baylin SB, Herman JG, Brock MV: Promoter hypermethylation of resected bronchial margins: a field defect of changes?. Clin Cancer Res. 2004, 10: 5131-5136. 10.1158/1078-0432.CCR-03-0763.
Article
CAS
PubMed
Google Scholar
Beane J, Sebastiani P, Liu G, Brody JS, Lenburg ME, Spira A: Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression. Genome Biol. 2007, 8: R201-10.1186/gb-2007-8-9-r201.
Article
PubMed
PubMed Central
Google Scholar
Yu Z, Zhai G, Singmann P, He Y, Xu T, Prehn C, Römisch-Margl W, Lattka E, Gieger C, Soranzo N, Heinrich J, Standl M, Thiering E, Mittelstraß K, Wichmann HE, Peters A, Suhre K, Li Y, Adamski J, Spector TD, Illig T, Wang-Sattler R: Human serum metabolic profiles are age dependent. Aging cell. 2012, 11: 960-967. 10.1111/j.1474-9726.2012.00865.x.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ellis JK, Athersuch TJ, Thomas LD, Teichert F, Pérez-Trujillo M, Svendsen C, Spurgeon DJ, Singh R, Järup L, Bundy JG, Keun HC: Metabolic profiling detects early effects of environmental and lifestyle exposure to cadmium in a human population. BMC Med. 2012, 10: 61-10.1186/1741-7015-10-61.
Article
CAS
PubMed
PubMed Central
Google Scholar
Vulimiri SV, Misra M, Hamm JT, Mitchell M, Berger A: Effects of mainstream cigarette smoke on the global metabolome of human lung epithelial cells. Chem Res Toxicol. 2009, 22: 492-503. 10.1021/tx8003246.
Article
CAS
PubMed
Google Scholar
Holle R, Happich M, Löwel H, Wichmann HE: KORA--a research platform for population based health research. Gesundheitswesen. 2005, 67 (Suppl 1): S19-25.
Article
PubMed
Google Scholar
Wichmann H-E, Gieger C, Illig T: KORA-gen--resource for population genetics, controls and a broad spectrum of disease phenotypes. Gesundheitswesen. 2005, 67 (Suppl 1): S26-30.
Article
PubMed
Google Scholar
Wang-Sattler R, Yu Z, Herder C, Messias AC, Floegel A, He Y, Heim K, Campillos M, Holzapfel C, Thorand B, Grallert H, Xu T, Bader E, Huth C, Mittelstrass K, Döring A, Meisinger C, Gieger C, Prehn C, Roemisch-Margl W, Carstensen M, Xie L, Yamanaka-Okumura H, Xing G, Ceglarek U, Thiery J, Giani G, Lickert H, Lin X, Li Y, et al: Novel biomarkers for pre-diabetes identified by metabolomics. Mol Syst Biol. 2012, 8: 615.
Article
PubMed
PubMed Central
Google Scholar
Mittelstrass K, Ried JS, Yu Z, Krumsiek J, Gieger C, Prehn C, Roemisch-Margl W, Polonikov A, Peters A, Theis FJ, Meitinger T, Kronenberg F, Weidinger S, Wichmann HE, Suhre K, Wang-Sattler R, Adamski J, Illig T: Discovery of sexual dimorphisms in metabolic and genetic biomarkers. PLoS Genet. 2011, 7: e1002215-10.1371/journal.pgen.1002215.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jourdan C, Petersen A-K, Gieger C, Döring A, Illig T, Wang-Sattler R, Meisinger C, Peters A, Adamski J, Prehn C, Suhre K, Altmaier E, Kastenmüller G, Römisch-Margl W, Theis FJ, Krumsiek J, Wichmann H-E, Linseisen J: Body fat free mass is associated with the serum metabolite profile in a population-based study. PLoS One. 2012, 7: e40009-10.1371/journal.pone.0040009.
Article
CAS
PubMed
PubMed Central
Google Scholar
Illig T, Gieger C, Zhai G, Römisch-Margl W, Wang-Sattler R, Prehn C, Altmaier E, Kastenmüller G, Kato BS, Mewes H-W, Meitinger T, Angelis MH de, Kronenberg F, Soranzo N, Wichmann H-E, Spector TD, Adamski J, Suhre K: A genome-wide perspective of genetic variation in human metabolism. Nat Genet. 2010, 42: 137-141. 10.1038/ng.507.
Article
CAS
PubMed
Google Scholar
Römisch-Margl W, Prehn C, Bogumil R, Röhring C, Suhre K, Adamski J: Procedure for tissue sample preparation and metabolite extraction for high-throughput targeted metabolomics. Metabolomics. 2012, 8: 133-142. 10.1007/s11306-011-0293-4.
Article
Google Scholar
Benjamini Y, Hochberg Y: Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Statist Soc B. 1995, 57: 289-300.
Google Scholar
NCI Dictionary of Cancer Terms. [http://www.cancer.gov/dictionary?CdrID%20=%20306510]
Szklarczyk D, Franceschini A, Kuhn M, Simonovic M, Roth A, Minguez P, Doerks T, Stark M, Muller J, Bork P, Jensen LJ, von Mering C: The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res. 2011, 39: D561-568. 10.1093/nar/gkq973.
Article
CAS
PubMed
Google Scholar
Wishart DS, Knox C, Guo AC, Eisner R, Young N, Gautam B, Hau DD, Psychogios N, Dong E, Bouatra S, Mandal R, Sinelnikov I, Xia J, Jia L, Cruz JA, Lim E, Sobsey CA, Shrivastava S, Huang P, Liu P, Fang L, Peng J, Fradette R, Cheng D, Tzur D, Clements M, Lewis A, De Souza A, Zuniga A, Dawe M, et al: HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009, 37: D603-610. 10.1093/nar/gkn810.
Article
CAS
PubMed
Google Scholar
Dijkstra EW: A note on two problems in connexion with graphs. Numerische Mathematik. 1959, 1: 269-271. 10.1007/BF01386390.
Article
Google Scholar
He Y, Yu Z, Giegling I, Xie L, Hartmann AM, Prehn C, Adamski J, Kahn R, Li Y, Illig T, Wang-Sattler R, Rujescu D: Schizophrenia shows a unique metabolomics signature in plasma. Transl Psychiatry. 2012, 2: e149-10.1038/tp.2012.76.
Article
CAS
PubMed
PubMed Central
Google Scholar
Csardi G, Nepusz T: The igraph software package for complex network research. InterJournal. 2006, Complex Systems: 1695.
Google Scholar
Smoot ME, Ono K, Ruscheinski J, Wang P-L, Ideker T: Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics. 2011, 27: 431-432. 10.1093/bioinformatics/btq675.
Article
CAS
PubMed
Google Scholar
Xia J, Mandal R, Sinelnikov IV, Broadhurst D, Wishart DS: MetaboAnalyst 2.0--a comprehensive server for metabolomic data analysis. Nucleic Acids Res. 2012, 40: W127-133. 10.1093/nar/gks374.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kris-Etherton PM: AHA Science Advisory. Monounsaturated fatty acids and risk of cardiovascular disease. American Heart Association. Nutrition Committee. Circulation. 1999, 100: 1253-1258. 10.1161/01.CIR.100.11.1253.
Article
CAS
PubMed
Google Scholar
Mozaffarian D, Rimm EB, Herrington DM: Dietary fats, carbohydrate, and progression of coronary atherosclerosis in postmenopausal women. Am J Clin Nutr. 2004, 80: 1175-1184.
CAS
PubMed
PubMed Central
Google Scholar
Shah SH, Bain JR, Muehlbauer MJ, Stevens RD, Crosslin DR, Haynes C, Dungan J, Newby LK, Hauser ER, Ginsburg GS, Newgard CB, Kraus WE: Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events. Circ Cardiovasc Genet. 2010, 3: 207-214. 10.1161/CIRCGENETICS.109.852814.
Article
CAS
PubMed
Google Scholar
Bridges CC, Kekuda R, Wang H, Prasad PD, Mehta P, Huang W, Smith SB, Ganapathy V: Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2001, 42: 47-54.
CAS
PubMed
Google Scholar
Harrison D, Griendling KK, Landmesser U, Hornig B, Drexler H: Role of oxidative stress in atherosclerosis. Am J Cardiol. 2003, 91: 7-11. 10.1016/S0002-9149(02)03144-2.
Article
Google Scholar
Glass CK, Witztum JL: Atherosclerosis. The road ahead. Cell. 2001, 104: 503-516. 10.1016/S0092-8674(01)00238-0.
Article
CAS
PubMed
Google Scholar
Palmerini CA, Saccardi C, Ferracci F, Arienti S: Lipid patterns in the saliva of smoking young adults. Hum Exp Toxicol. 2011, 30: 1482-1488. 10.1177/0960327111398672.
Article
CAS
PubMed
Google Scholar
Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung Y-M, Wu Y, Schauer P, Smith JD, Allayee H, Tang WHW, DiDonato JA, Lusis AJ, Hazen SL: Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011, 472: 57-63. 10.1038/nature09922.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nakagawa K, Shibata A, Saito T, Sookwong P, Kato S, Tsuduki T, Matsubara K, Miyazawa T: Phosphatidylcholine hydroperoxide promotes VEGF-induced angiogenesis in endothelial cells and rat aorta ring cultures. Biochim Biophys Acta. 2011, 1810: 1205-1211. 10.1016/j.bbagen.2011.08.018.
Article
CAS
PubMed
Google Scholar
Danesh J, Collins R, Appleby P, Peto R: Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. JAMA. 1998, 279: 1477-1482. 10.1001/jama.279.18.1477.
Article
CAS
PubMed
Google Scholar
Gibney MJ, Walsh M, Brennan L, Roche HM, German B, van Ommen B: Metabolomics in human nutrition: opportunities and challenges. Am J Clin Nutr. 2005, 82: 497-503.
CAS
PubMed
Google Scholar
Pohjanen E, Thysell E, Jonsson P, Eklund C, Silfver A, Carlsson I-B, Lundgren K, Moritz T, Svensson MB, Antti H: A multivariate screening strategy for investigating metabolic effects of strenuous physical exercise in human serum. J Proteome Res. 2007, 6: 2113-2120. 10.1021/pr070007g.
Article
CAS
PubMed
Google Scholar