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  1. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver illness with a genetically heterogeneous background that can be accompanied by considerable morbidity and attendant health care costs. The pa...

    Authors: Bahram Namjou, Todd Lingren, Yongbo Huang, Sreeja Parameswaran, Beth L. Cobb, Ian B. Stanaway, John J. Connolly, Frank D. Mentch, Barbara Benoit, Xinnan Niu, Wei-Qi Wei, Robert J. Carroll, Jennifer A. Pacheco, Isaac T. W. Harley, Senad Divanovic, David S. Carrell…

    Citation: BMC Medicine 2019 17:135

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  2. Content type: Research article

    Risk prediction models are commonly used in practice to inform decisions on patients’ treatment. Uncertainty around risk scores beyond the confidence interval is rarely explored. We conducted an uncertainty an...

    Authors: Alexander Pate, Richard Emsley, Darren M. Ashcroft, Benjamin Brown and Tjeerd van Staa

    Citation: BMC Medicine 2019 17:134

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    The Correction to this article has been published in BMC Medicine 2019 17:158

  3. Content type: Debate

    There is great interest in and excitement about the concept of personalized or precision medicine and, in particular, advancing this vision via various ‘big data’ efforts. While these methods are necessary, th...

    Authors: Eric B. Hekler, Predrag Klasnja, Guillaume Chevance, Natalie M. Golaszewski, Dana Lewis and Ida Sim

    Citation: BMC Medicine 2019 17:133

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  4. Content type: Research article

    Smartphone apps are becoming increasingly popular for supporting diabetes self-management. A key aspect of diabetes self-management is appropriate medication-taking. This study aims to systematically assess an...

    Authors: Zhilian Huang, Elaine Lum, Geronimo Jimenez, Monika Semwal, Peter Sloot and Josip Car

    Citation: BMC Medicine 2019 17:127

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  5. Content type: Research article

    Hospitalisation is often harmful for people with dementia and results in high societal costs, so avoidance of unnecessary admissions is a global priority. However, no intervention has yet reduced admissions of...

    Authors: Hilary Shepherd, Gill Livingston, Justin Chan and Andrew Sommerlad

    Citation: BMC Medicine 2019 17:130

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  6. Content type: Research article

    Studies have suggested sex differences in the mortality rate associated with diabetes. We conducted a meta-analysis to estimate the relative effect of diabetes on the risk of all-cause, cancer, cardiovascular ...

    Authors: Yafeng Wang, Adrienne O’Neil, Yurui Jiao, Lijun Wang, Jingxin Huang, Yutao Lan, Yikun Zhu and Chuanhua Yu

    Citation: BMC Medicine 2019 17:136

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  7. Content type: Research article

    Monogenic diabetes (MgD) accounts for 1–2% of all diabetes cases. In adults, MgD is difficult to distinguish from common diabetes causes. We assessed the diagnosis rate and genetic spectrum of MgD using next-g...

    Authors: Xavier Donath, Cécile Saint-Martin, Danièle Dubois-Laforgue, Ramanan Rajasingham, François Mifsud, Cécile Ciangura, José Timsit and Christine Bellanné-Chantelot

    Citation: BMC Medicine 2019 17:132

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  8. Content type: Research article

    Autoimmune diseases are often preceded by an asymptomatic autoantibody-positive phase. In type 1 diabetes, the detection of autoantibodies to pancreatic islet antigens in genetically at-risk children is progno...

    Authors: Verena Sophia Hoffmann, Andreas Weiß, Christiane Winkler, Annette Knopff, Manja Jolink, Ezio Bonifacio and Anette-G. Ziegler

    Citation: BMC Medicine 2019 17:125

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  9. Content type: Research article

    Many parts of Africa have witnessed reductions in Plasmodium falciparum transmission over the last 15 years. Since immunity to malaria is acquired more rapidly at higher transmission, the slower acquisition of im...

    Authors: Patricia Njuguna, Kathryn Maitland, Amek Nyaguara, Daniel Mwanga, Polycarp Mogeni, Neema Mturi, Shebe Mohammed, Gabriel Mwambingu, Caroline Ngetsa, Kenedy Awuondo, Brett Lowe, Ifedayo Adetifa, J. Anthony G. Scott, Thomas N. Williams, Sarah Atkinson, Faith Osier…

    Citation: BMC Medicine 2019 17:124

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  10. Content type: Research article

    Every year, 90,000 people may die from melioidosis. Vaccine candidates have not proceeded past animal studies, partly due to uncertainty around the potential market size. This study aims to estimate the potent...

    Authors: Nantasit Luangasanatip, Stefan Flasche, David A. B. Dance, Direk Limmathurotsakul, Bart J. Currie, Chiranjay Mukhopadhyay, Tim Atkins, Richard Titball and Mark Jit

    Citation: BMC Medicine 2019 17:129

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  11. Content type: Research article

    Tobacco smoking is a leading cause of cardiovascular disease (CVD) morbidity and mortality. Evidence on the relation of smoking to different subtypes of CVD, across fatal and non-fatal outcomes, is limited.

    Authors: Emily Banks, Grace Joshy, Rosemary J. Korda, Bill Stavreski, Kay Soga, Sam Egger, Cathy Day, Naomi E. Clarke, Sarah Lewington and Alan D. Lopez

    Citation: BMC Medicine 2019 17:128

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  12. Content type: Research article

    Recovery following a stroke is a long and ongoing process. Post-stroke follow-up after leaving the hospital is recommended. Methods for follow-up patients include face-to-face, via the telephone, post or onlin...

    Authors: Jonathan Hewitt, Anna Pennington, Alexander Smith, Stephanie Gething, Michelle Price, James White, Richard Dewar and Ben Carter

    Citation: BMC Medicine 2019 17:111

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  13. Content type: Research article

    World Health Organization rehydration management guidelines (plan C) for severe dehydration are widely practiced in resource-poor settings, but never formally evaluated in a trial. The Fluid Expansion as a Sup...

    Authors: Kirsty A. Houston, Jack Gibb, Peter Olupot-Olupot, Nchafatso Obonyo, Ayub Mpoya, Margaret Nakuya, Rita Muhindo, Sophie Uyoga, Jennifer A. Evans, Roisin Connon, Diana M. Gibb, Elizabeth C. George and Kathryn Maitland

    Citation: BMC Medicine 2019 17:122

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  14. Content type: Correspondence

    Type 2 diabetes mellitus (T2DM) is a major cause of morbidity and mortality worldwide. Early interventions may help to delay or prevent onset of cardiometabolic endpoints of clinical importance to T2DM patients.

    Authors: Efstathia Gkioni, Ketevan Glonti, Susanna Dodd and Carrol Gamble

    Citation: BMC Medicine 2019 17:121

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    The Correspondence to this article has been published in BMC Medicine 2019 17:162

    The original article was published in BMC Medicine 2017 15:146

  15. Content type: Research article

    Verbal autopsies with physician assignment of cause of death (COD) are commonly used in settings where medical certification of deaths is uncommon. It remains unanswered if automated algorithms can replace phy...

    Authors: Prabhat Jha, Dinesh Kumar, Rajesh Dikshit, Atul Budukh, Rehana Begum, Prabha Sati, Patrycja Kolpak, Richard Wen, Shyamsundar J. Raithatha, Utkarsh Shah, Zehang Richard Li, Lukasz Aleksandrowicz, Prakash Shah, Kapila Piyasena, Tyler H. McCormick, Hellen Gelband…

    Citation: BMC Medicine 2019 17:116

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    The Commentary to this article has been published in BMC Medicine 2019 17:131

  16. Content type: Research article

    Abnormal BMI is associated with discouraging IVF outcomes in fresh autologous or oocyte donor cycles, whether or not such a relation also holds true for women undergoing frozen-thawed embryo transfer (FET) rem...

    Authors: Jie Zhang, Hongfang Liu, Xiaoyan Mao, Qiuju Chen, Yong Fan, Yitao Xiao, Yun Wang and Yanping Kuang

    Citation: BMC Medicine 2019 17:114

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  17. Content type: Research article

    HIV epidemiology among female sex workers (FSWs) and their clients in the Middle East and North Africa (MENA) region is poorly understood. We addressed this gap through a comprehensive epidemiological assessment.

    Authors: Hiam Chemaitelly, Helen A. Weiss, Clara Calvert, Manale Harfouche and Laith J. Abu-Raddad

    Citation: BMC Medicine 2019 17:119

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  18. Content type: Opinion

    For many infectious conditions, the optimal antibiotic course length remains unclear. The estimation of course length must consider the important trade-off between maximising short- and long-term efficacy and ...

    Authors: Koen B. Pouwels, Mo Yin, Christopher C. Butler, Ben S. Cooper, Sarah Wordsworth, A. Sarah Walker and Julie V. Robotham

    Citation: BMC Medicine 2019 17:115

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  19. Content type: Research article

    Although peer reviewers play a key role in the manuscript review process, their roles and tasks are poorly defined. Clarity around this issue is important as it may influence the quality of peer reviewer repor...

    Authors: Ketevan Glonti, Daniel Cauchi, Erik Cobo, Isabelle Boutron, David Moher and Darko Hren

    Citation: BMC Medicine 2019 17:118

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  20. Content type: Research article

    Personalized medicine is the tailoring of treatment to the individual characteristics of patients. Once a treatment has been tested in a clinical trial and its effect overall quantified, it would be of great v...

    Authors: Francesca Bovis, Luca Carmisciano, Alessio Signori, Matteo Pardini, Joshua R. Steinerman, Thomas Li, Aaron P. Tansy and Maria Pia Sormani

    Citation: BMC Medicine 2019 17:113

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  21. Content type: Research article

    Postmarketing commitments are clinical studies that pharmaceutical companies agree to conduct at the time of FDA approval, but which are not required by statute or regulation. As FDA increasingly adopts a life...

    Authors: Joshua D. Wallach, Anita T. Luxkaranayagam, Sanket S. Dhruva, Jennifer E. Miller and Joseph S. Ross

    Citation: BMC Medicine 2019 17:117

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  22. Content type: Research article

    Pharmacogenetics (PGx) is currently implemented in hospitals to optimize therapy with high-risk drugs. However, many drugs with dosing recommendations from the Dutch Pharmacogenetics Working Group and the Clin...

    Authors: P. C. D. Bank, J. J. Swen and H. J. Guchelaar

    Citation: BMC Medicine 2019 17:110

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  23. Content type: Research article

    The Framingham risk models and pooled cohort equations (PCE) are widely used and advocated in guidelines for predicting 10-year risk of developing coronary heart disease (CHD) and cardiovascular disease (CVD) ...

    Authors: Johanna A. Damen, Romin Pajouheshnia, Pauline Heus, Karel G. M. Moons, Johannes B. Reitsma, Rob J. P. M. Scholten, Lotty Hooft and Thomas P. A. Debray

    Citation: BMC Medicine 2019 17:109

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  24. Content type: Research article

    Multimorbidity is an emerging public health priority. Physical activity (PA) is recommended as one of the main lifestyle behaviours, yet the benefits of PA for people with multimorbidity are unclear. We assess...

    Authors: Yogini V. Chudasama, Kamlesh K. Khunti, Francesco Zaccardi, Alex V. Rowlands, Thomas Yates, Clare L. Gillies, Melanie J. Davies and Nafeesa N. Dhalwani

    Citation: BMC Medicine 2019 17:108

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  25. Content type: Research article

    Infectious disease epidemics are a constant threat, and while we can strengthen preparedness in advance, inevitably, we will sometimes be caught unaware by novel outbreaks. To address the challenge of rapidly ...

    Authors: Louise Sigfrid, Catrin Moore, Alex P. Salam, Nicola Maayan, Candyce Hamel, Chantelle Garritty, Vittoria Lutje, Brian Buckley, Karla Soares-Weiser, Rachel Marshall, Mike Clarke and Peter Horby

    Citation: BMC Medicine 2019 17:107

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  26. Content type: Research article

    Intratumoral immune infiltrates have manifested a robust prognostic signature in patients with hepatocellular carcinoma (HCC). We hypothesized that a novel tissue-related immune signature (TRIS) could improve ...

    Authors: Meng-Xin Tian, Wei-Ren Liu, Han Wang, Yu-Fu Zhou, Lei Jin, Xi-Fei Jiang, Chen-Yang Tao, Zheng Tang, Pei-Yun Zhou, Yuan Fang, Wei-Feng Qu, Zhen-Bin Ding, Yuan-Fei Peng, Zhi Dai, Shuang-Jian Qiu, Jian Zhou…

    Citation: BMC Medicine 2019 17:106

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  27. Content type: Research article

    News stories represent an important source of information. We aimed to evaluate the impact of “spin” (i.e., misrepresentation of study results) in health news stories reporting studies of pharmacologic treatme...

    Authors: Isabelle Boutron, Romana Haneef, Amélie Yavchitz, Gabriel Baron, John Novack, Ivan Oransky, Gary Schwitzer and Philippe Ravaud

    Citation: BMC Medicine 2019 17:105

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    The Correction to this article has been published in BMC Medicine 2019 17:147

  28. Content type: Correspondence

    Reducing maternal mortality is a key focus of development strategies and one of the indicators used to measure progress towards achieving the Sustainable Development Goals. In the absence of medical certificat...

    Authors: Ian D. Riley, Riley H. Hazard, Rohina Joshi, Hafizur Rahman Chowdhury and Alan D. Lopez

    Citation: BMC Medicine 2019 17:104

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  29. Content type: Research article

    Accurate and timely diagnosis of malaria is essential for disease management and surveillance. Thin and thick blood smear microscopy and malaria rapid diagnostic tests (RDTs) are standard malaria diagnostics, ...

    Authors: Annelies Post, Berenger Kaboré, Isaie J. Reuling, Joel Bognini, Wouter van der Heijden, Salou Diallo, Palpouguini Lompo, Basile Kam, Natacha Herssens, Kjerstin Lanke, Teun Bousema, Robert W. Sauerwein, Halidou Tinto, Jan Jacobs, Quirijn de Mast and Andre J. van der Ven

    Citation: BMC Medicine 2019 17:103

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  30. Content type: Software

    Verbal autopsy is an increasingly important methodology for assigning causes to otherwise uncertified deaths, which amount to around 50% of global mortality and cause much uncertainty for health planning. The ...

    Authors: Peter Byass, Laith Hussain-Alkhateeb, Lucia D’Ambruoso, Samuel Clark, Justine Davies, Edward Fottrell, Jon Bird, Chodziwadziwa Kabudula, Stephen Tollman, Kathleen Kahn, Linus Schiöler and Max Petzold

    Citation: BMC Medicine 2019 17:102

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  31. Content type: Research article

    Specific phobia (SP) is a relatively common disorder associated with high levels of psychiatric comorbidity. Because of its early onset, SP may be a useful early marker of internalizing psychopathology, especi...

    Authors: Ymkje Anna de Vries, Ali Al-Hamzawi, Jordi Alonso, Guilherme Borges, Ronny Bruffaerts, Brendan Bunting, José Miguel Caldas-de-Almeida, Alfredo H. Cia, Giovanni De Girolamo, Rumyana V. Dinolova, Oluyomi Esan, Silvia Florescu, Oye Gureje, Josep Maria Haro, Chiyi Hu, Elie G. Karam…

    Citation: BMC Medicine 2019 17:101

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  32. Content type: Research article

    Prediabetes appears to be increasing worldwide. This study examined the incidence of prediabetes among immigrants to Canada of different ethnic origins and the age at which ethnic differences emerged.

    Authors: Ghazal S. Fazli, Rahim Moineddin, Arlene S. Bierman and Gillian L. Booth

    Citation: BMC Medicine 2019 17:100

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  33. Content type: Research article

    School neighborhood food environment is recognized as an important contributor to childhood obesity; however, large-scale and longitudinal studies remain limited. This study aimed to examine this association a...

    Authors: Peng Jia, Hong Xue, Xi Cheng and Youfa Wang

    Citation: BMC Medicine 2019 17:99

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  34. Content type: Correspondence

    We thank Daly-Smith et al. for taking the time to read the results of our pilot research study, describing it as an important and welcome contribution. Nonetheless, the authors argue six points against our con...

    Authors: Ross A. Chesham, Josephine N. Booth, Emma L. Sweeney, Gemma C. Ryde, Trish Gorely, Naomi E. Brooks and Colin N. Moran

    Citation: BMC Medicine 2019 17:97

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    The original article was published in BMC Medicine 2019 17:96

  35. Content type: Correspondence

    A recent pilot study by Chesham et al. in BMC Medicine established some initial effects of the Daily Mile™ using a quasi-experimental repeated measures design, with valid and reliable outcome assessments for mode...

    Authors: Andy Daly-Smith, Jade L. Morris, Matthew Hobbs and Jim McKenna

    Citation: BMC Medicine 2019 17:96

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    The Correspondence to this article has been published in BMC Medicine 2019 17:97

    The original article was published in BMC Medicine 2018 16:64

  36. Content type: Research article

    Acute kidney injury (AKI) is a recognized complication of pediatric severe malaria, but its long-term consequences are unknown.

    Authors: Andrea L. Conroy, Robert O. Opoka, Paul Bangirana, Richard Idro, John M. Ssenkusu, Dibyadyuti Datta, James S. Hodges, Catherine Morgan and Chandy C. John

    Citation: BMC Medicine 2019 17:98

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  37. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) is a common condition that progresses in some patients to steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC). Here we used healthcare records of 18 m...

    Authors: Myriam Alexander, A. Katrina Loomis, Johan van der Lei, Talita Duarte-Salles, Daniel Prieto-Alhambra, David Ansell, Alessandro Pasqua, Francesco Lapi, Peter Rijnbeek, Mees Mosseveld, Dawn M. Waterworth, Stuart Kendrick, Naveed Sattar and William Alazawi

    Citation: BMC Medicine 2019 17:95

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    The Commentary to this article has been published in BMC Medicine 2019 17:123

  38. Content type: Research article

    In recent years, we witnessed a resurgence of measles even in countries where, according to WHO guidelines, elimination should have already been achieved. In high-income countries, the raise of anti-vaccinatio...

    Authors: Filippo Trentini, Piero Poletti, Alessia Melegaro and Stefano Merler

    Citation: BMC Medicine 2019 17:86

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  39. Content type: Research article

    Misleading news claims can be detrimental to public health. We aimed to improve the alignment between causal claims and evidence, without losing news interest (counter to assumptions that news is not intereste...

    Authors: Rachel C. Adams, Aimée Challenger, Luke Bratton, Jacky Boivin, Lewis Bott, Georgina Powell, Andy Williams, Christopher D. Chambers and Petroc Sumner

    Citation: BMC Medicine 2019 17:91

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  40. Content type: Research article

    Frailty index (FI) is a well-established predictor of all-cause mortality, but less is known for cause-specific mortality and whether familial effects influence the associations. Middle-aged individuals are al...

    Authors: Xia Li, Alexander Ploner, Ida K. Karlsson, Xingrong Liu, Patrik K. E. Magnusson, Nancy L. Pedersen, Sara Hägg and Juulia Jylhävä

    Citation: BMC Medicine 2019 17:94

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  41. Content type: Research article

    The World Health Organization (WHO) International Classification of Diseases and Related Health Problems (ICD) is used globally by 194 WHO member nations. It is used for assigning clinical diagnoses, providing...

    Authors: Angélica M. Claudino, Kathleen M. Pike, Phillipa Hay, Jared W. Keeley, Spencer C. Evans, Tahilia J. Rebello, Rachel Bryant-Waugh, Yunfei Dai, Min Zhao, Chihiro Matsumoto, Cecile Rausch Herscovici, Blanca Mellor-Marsá, Anne-Claire Stona, Cary S. Kogan, Howard F. Andrews, Palmiero Monteleone…

    Citation: BMC Medicine 2019 17:93

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  42. Content type: Research article

    Understanding where adults with diabetes in India are lost in the diabetes care cascade is essential for the design of targeted health interventions and to monitor progress in health system performance for man...

    Authors: Jonas Prenissl, Lindsay M. Jaacks, Viswanathan Mohan, Jennifer Manne-Goehler, Justine I. Davies, Ashish Awasthi, Anne Christine Bischops, Rifat Atun, Till Bärnighausen, Sebastian Vollmer and Pascal Geldsetzer

    Citation: BMC Medicine 2019 17:92

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