Skip to main content

Articles

Page 2 of 58

  1. All countries are facing decisions about which population groups to prioritize for access to COVID-19 vaccination after the first vaccine products have been licensed, at which time supply shortages are inevita...

    Authors: Juan Yang, Wen Zheng, Huilin Shi, Xuemei Yan, Kaige Dong, Qian You, Guangjie Zhong, Hui Gong, Zhiyuan Chen, Mark Jit, Cecile Viboud, Marco Ajelli and Hongjie Yu

    Citation: BMC Medicine 2021 19:45

    Content type: Research article

    Published on:

  2. The cardiovascular health index (CVHI) introduced by the American Heart Association is a valid, accessible, simple, and translatable metric for monitoring cardiovascular health in a population. Components of t...

    Authors: Engelbert A. Nonterah, Nigel J. Crowther, Abraham Oduro, Godfred Agongo, Lisa K. Micklesfield, Palwendé R. Boua, Solomon S. R. Choma, Shukri F. Mohamed, Herman Sorgho, Stephen M. Tollman, Shane A. Norris, Frederick J. Raal, Diederick E. Grobbee, Michelé Ramsay, Michiel L. Bots and Kerstin Klipstein-Grobusch

    Citation: BMC Medicine 2021 19:30

    Content type: Research article

    Published on:

  3. The Southern European Atlantic Diet (SEAD) is the traditional diet of Northern Portugal and North-Western Spain. Higher adherence to the SEAD has been associated with lower levels of some cardiovascular risk f...

    Authors: Adrián Carballo-Casla, Rosario Ortolá, Esther García-Esquinas, Andreia Oliveira, Mercedes Sotos-Prieto, Carla Lopes, Esther Lopez-Garcia and Fernando Rodríguez-Artalejo

    Citation: BMC Medicine 2021 19:36

    Content type: Research article

    Published on:

  4. The frailty index (FI) is a well-recognized measurement for risk stratification in older people. Among middle-aged and older people, we examined the prospective association between the FI and mortality as well...

    Authors: R. C. Oude Voshaar, H. W. Jeuring, M. K. Borges, R. H. S. van den Brink, R. M. Marijnissen, E. O. Hoogendijk, B. van Munster and I. Aprahamian

    Citation: BMC Medicine 2021 19:29

    Content type: Research article

    Published on:

  5. Preterm birth affects almost 9–11% of newborns and is one of the leading causes of childhood neurodevelopmental disabilities; the underlying molecular networks are poorly defined. In neurons, retrotransposons ...

    Authors: Camilla Fontana, Federica Marasca, Livia Provitera, Sara Mancinelli, Nicola Pesenti, Shruti Sinha, Sofia Passera, Sergio Abrignani, Fabio Mosca, Simona Lodato, Beatrice Bodega and Monica Fumagalli

    Citation: BMC Medicine 2021 19:42

    Content type: Research article

    Published on:

  6. Non-pharmaceutical interventions (NPIs) are used to reduce transmission of SARS coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19). However, empirical evidence of the effectiveness of s...

    Authors: Yang Liu, Christian Morgenstern, James Kelly, Rachel Lowe and Mark Jit

    Citation: BMC Medicine 2021 19:40

    Content type: Research article

    Published on:

  7. There is little information on care-seeking patterns for sexual assault and domestic violence during the COVID-19 pandemic. The objective of this study was to examine the changes in emergency department (ED) a...

    Authors: Katherine A. Muldoon, Kathryn M. Denize, Robert Talarico, Deshayne B. Fell, Agnes Sobiesiak, Melissa Heimerl and Kari Sampsel

    Citation: BMC Medicine 2021 19:20

    Content type: Research article

    Published on:

  8. With increasing life expectancy in China, no large population-based studies have been done on the trend for musculoskeletal disorders in China. We have investigated the pattern and trend of five major musculos...

    Authors: Dongze Wu, Priscilla Wong, Cui Guo, Lai-Shan Tam and Jieruo Gu

    Citation: BMC Medicine 2021 19:34

    Content type: Research article

    Published on:

  9. The COVID-19 pandemic has disrupted routine measles immunisation and supplementary immunisation activities (SIAs) in most countries including Kenya. We assessed the risk of measles outbreaks during the pandemi...

    Authors: C. N. Mburu, J. Ojal, R. Chebet, D. Akech, B. Karia, J. Tuju, A. Sigilai, K. Abbas, M. Jit, S. Funk, G. Smits, P. G. M. van Gageldonk, F. R. M. van der Klis, C. Tabu, D. J. Nokes, JAG Scott…

    Citation: BMC Medicine 2021 19:35

    Content type: Research article

    Published on:

  10. To manage the risk factors and to improve clinical outcomes, patients with stroke commonly receive multiple cardiovascular medications. However, there is a lack of evidence on the optimum combination of medica...

    Authors: Tian-Tian Ma, Ian C. K. Wong, Cate Whittlesea, Kenneth K. C. Man, Wallis Lau, Zixuan Wang, Ruth Brauer, Thomas M. MacDonald, Isla S. Mackenzie and Li Wei

    Citation: BMC Medicine 2021 19:24

    Content type: Research article

    Published on:

  11. A critical and challenging process in immunotherapy is to identify cancer patients who could benefit from immune checkpoint inhibitors (ICIs). Exploration of predictive biomarkers could help to maximize the cl...

    Authors: Zhen Zhang, Hao-Xiang Wu, Wu-Hao Lin, Zi-Xian Wang, Lu-Ping Yang, Zhao-Lei Zeng and Hui-Yan Luo

    Citation: BMC Medicine 2021 19:26

    Content type: Research article

    Published on:

  12. Although there are many clinical and molecular biomarkers in acute myeloid leukemia (AML), the novel and reliable biomarkers are still required to predict the overall survival at the time of disease diagnosis.

    Authors: Jinghan Wang, Jiajia Pan, Shujuan Huang, Fenglin Li, Jiansong Huang, Xia Li, Qing Ling, Wenle Ye, Yungui Wang, Wenjuan Yu and Jie Jin

    Citation: BMC Medicine 2021 19:28

    Content type: Research article

    Published on:

  13. SARS-CoV-2 has induced a worldwide pandemic and subsequent non-pharmaceutical interventions (NPIs) to control the spread of the virus. As in many countries, the SARS-CoV-2 pandemic in Germany has led to a cons...

    Authors: Sahamoddin Khailaie, Tanmay Mitra, Arnab Bandyopadhyay, Marta Schips, Pietro Mascheroni, Patrizio Vanella, Berit Lange, Sebastian C. Binder and Michael Meyer-Hermann

    Citation: BMC Medicine 2021 19:32

    Content type: Research article

    Published on:

  14. Sex hormones have been suggested to play a role in colorectal cancer (CRC), but their influence on early initiation of CRC remains unknown.

    Authors: Dong Hang, Xiaosheng He, Ane Sørlie Kværner, Andrew T. Chan, Kana Wu, Shuji Ogino, Zhibin Hu, Hongbing Shen, Edward L. Giovannucci and Mingyang Song

    Citation: BMC Medicine 2021 19:18

    Content type: Research article

    Published on:

  15. Prognostic models developed in general cohorts with a mixture of heart failure (HF) phenotypes, though more widely applicable, are also likely to yield larger prediction errors in settings where the HF phenoty...

    Authors: Yuntao Chen, Adriaan A. Voors, Tiny Jaarsma, Chim C. Lang, Iziah E. Sama, K. Martijn Akkerhuis, Eric Boersma, Hans L. Hillege and Douwe Postmus

    Citation: BMC Medicine 2021 19:21

    Content type: Research article

    Published on:

  16. Studies systematically screening medications have successfully identified prescription medicines associated with cancer risk. However, adjustment for confounding factors in these studies has been limited. We t...

    Authors: R. D. McDowell, C. Hughes, P. Murchie and C. Cardwell

    Citation: BMC Medicine 2021 19:22

    Content type: Research article

    Published on:

  17. The World Health Organization (WHO) in 2015 stated that every effort should be made to provide cesarean delivery (CD) for women in need. In China, the two-child policy largely prompts the number of advanced ag...

    Authors: Ci Song, Yan Xu, Yuqing Ding, Yanfang Zhang, Na Liu, Lin Li, Zhun Li, Jiangbo Du, Hua You, Hongxia Ma, Guangfu Jin, Xudong Wang, Hongbing Shen, Yuan Lin, Xiaoqing Jiang and Zhibin Hu

    Citation: BMC Medicine 2021 19:14

    Content type: Research article

    Published on:

  18. The National Early Warning Score (NEWS2) is currently recommended in the UK for the risk stratification of COVID-19 patients, but little is known about its ability to detect severe cases. We aimed to evaluate ...

    Authors: Ewan Carr, Rebecca Bendayan, Daniel Bean, Matt Stammers, Wenjuan Wang, Huayu Zhang, Thomas Searle, Zeljko Kraljevic, Anthony Shek, Hang T. T. Phan, Walter Muruet, Rishi K. Gupta, Anthony J. Shinton, Mike Wyatt, Ting Shi, Xin Zhang…

    Citation: BMC Medicine 2021 19:23

    Content type: Research article

    Published on:

  19. In utero exposure to Zika virus (ZIKV) is known to be associated with birth defects. The impact of in utero ZIKV exposure on neurodevelopmental outcomes in early childhood remains unclear. The objective of thi...

    Authors: Rebecca Grant, Olivier Fléchelles, Benoît Tressières, Mama Dialo, Narcisse Elenga, Nicolas Mediamolle, Adeline Mallard, Jean-Christophe Hebert, Noémie Lachaume, Elvire Couchy, Bruno Hoen and Arnaud Fontanet

    Citation: BMC Medicine 2021 19:12

    Content type: Research article

    Published on:

    The Commentary to this article has been published in BMC Medicine 2021 19:41

  20. Much progress has been made in mapping genetic abnormalities linked to amyotrophic lateral sclerosis (ALS), but the majority of cases still present with no known underlying cause. Furthermore, even in families...

    Authors: Sarah L. Boddy, Ilaria Giovannelli, Matilde Sassani, Johnathan Cooper-Knock, Michael P. Snyder, Eran Segal, Eran Elinav, Lynne A. Barker, Pamela J. Shaw and Christopher J. McDermott

    Citation: BMC Medicine 2021 19:13

    Content type: Review

    Published on:

  21. It has been well established that the TMEM106B gene rs1990622 variant was a frontotemporal dementia (FTD) risk factor. Until recently, growing evidence highlights the role of TMEM106B in Alzheimer’s disease (AD)....

    Authors: Yang Hu, Jing-yi Sun, Yan Zhang, Haihua Zhang, Shan Gao, Tao Wang, Zhifa Han, Longcai Wang, Bao-liang Sun and Guiyou Liu

    Citation: BMC Medicine 2021 19:11

    Content type: Research article

    Published on:

  22. Comorbidities affect outcomes in heart failure (HF), but are not reflected in current HF classification. The aim of this study is to characterize HF groups that account for higher-order interactions between co...

    Authors: Claudia Gulea, Rosita Zakeri and Jennifer K. Quint

    Citation: BMC Medicine 2021 19:9

    Content type: Research article

    Published on:

  23. Malnutrition continues to affect under-five children in Africa to an overwhelming proportion. The situation is further compounded by the burden of sickle cell disease (SCD). However, association of SCD with st...

    Authors: Mohammad Redwanul Islam, Md Moinuddin, Ayeda Ahmed and Syed Moshfiqur Rahman

    Citation: BMC Medicine 2021 19:5

    Content type: Research article

    Published on:

    The Commentary to this article has been published in BMC Medicine 2021 19:17

  24. A high body mass index (BMI) has been associated with increased risk of several cancers; however, whether BMI is related to a larger number of cancers than currently recognized is unclear. Moreover, whether wa...

    Authors: Martina Recalde, Veronica Davila-Batista, Yesika Díaz, Michael Leitzmann, Isabelle Romieu, Heinz Freisling and Talita Duarte-Salles

    Citation: BMC Medicine 2021 19:10

    Content type: Research article

    Published on:

  25. The etiologies of chronic neurological diseases, which heavily contribute to global disease burden, remain far from elucidated. Despite available umbrella reviews on single contributing factors or diseases, no...

    Authors: Alexios-Fotios A. Mentis, Efthimios Dardiotis, Vasiliki Efthymiou and George P. Chrousos

    Citation: BMC Medicine 2021 19:6

    Content type: Research article

    Published on:

  26. Cross-reactivity to SARS-CoV-2 from exposure to endemic human coronaviruses (eHCoV) is gaining increasing attention as a possible driver of both protection against infection and COVID-19 severity. Here we expl...

    Authors: Francesco Pinotti, Paul S. Wikramaratna, Uri Obolski, Robert S. Paton, Daniel S. C. Damineli, Luiz C. J. Alcantara, Marta Giovanetti, Sunetra Gupta and José Lourenço

    Citation: BMC Medicine 2021 19:19

    Content type: Research article

    Published on:

  27. Alcohol consumption is a leading contributor to death and disability worldwide, but previous research has not examined the effects of different patterns of alcohol consumption. The study objective was to under...

    Authors: Bhautesh Dinesh Jani, Ross McQueenie, Barbara I. Nicholl, Ryan Field, Peter Hanlon, Katie I. Gallacher, Frances S. Mair and Jim Lewsey

    Citation: BMC Medicine 2021 19:8

    Content type: Research article

    Published on:

  28. Adiposity is a strong risk factor for cancer incidence and mortality. However, most of the evidence available has focused on body mass index (BMI) as a marker of adiposity. There is limited evidence on relatio...

    Authors: Solange Parra-Soto, Emma S. Cowley, Leandro F. M. Rezende, Catterina Ferreccio, John C. Mathers, Jill P. Pell, Frederick K. Ho and Carlos Celis-Morales

    Citation: BMC Medicine 2021 19:7

    Content type: Research article

    Published on:

  29. Medical costs and the burden associated with cardiovascular disease are on the rise. Therefore, to improve the overall economy and quality assessment of the healthcare system, we developed a predictive model o...

    Authors: Tomoyuki Takura, Keiko Hirano Goto and Asao Honda

    Citation: BMC Medicine 2021 19:15

    Content type: Research article

    Published on:

  30. The optimal distribution between physical activity (PA) levels and sedentary behaviour (SB) for the greatest benefits for body composition among older adults with overweight/obesity and chronic health conditio...

    Authors: Aina M. Galmes-Panades, Jadwiga Konieczna, Veronica Varela-Mato, Itziar Abete, Nancy Babio, Miquel Fiol, José Antonio de Paz, Rosa Casas, Romina Olbeyra, Miguel Ruiz-Canela, Antoni Palau-Galindo, Olga Castañer, Arturo Martín-García, Ramón Estruch, Josep Vidal, Pilar Buil-Cosiales…

    Citation: BMC Medicine 2021 19:3

    Content type: Research article

    Published on:

  31. Nutrition and lifestyle have been long established as risk factors for colorectal cancer (CRC). Modifiable lifestyle behaviours bear potential to minimize long-term CRC risk; however, translation of lifestyle ...

    Authors: Krasimira Aleksandrova, Robin Reichmann, Rudolf Kaaks, Mazda Jenab, H. Bas Bueno-de-Mesquita, Christina C. Dahm, Anne Kirstine Eriksen, Anne Tjønneland, Fanny Artaud, Marie-Christine Boutron-Ruault, Gianluca Severi, Anika Hüsing, Antonia Trichopoulou, Anna Karakatsani, Eleni Peppa, Salvatore Panico…

    Citation: BMC Medicine 2021 19:1

    Content type: Research article

    Published on:

  32. Atrial fibrillation (AF) is common in older people with frailty and is associated with an increased risk of stroke and systemic embolism. Whilst oral anticoagulation is associated with a reduction in this risk...

    Authors: Chris Wilkinson, Jianhua Wu, Samuel D. Searle, Oliver Todd, Marlous Hall, Vijay Kunadian, Andrew Clegg, Kenneth Rockwood and Chris P. Gale

    Citation: BMC Medicine 2020 18:401

    Content type: Research article

    Published on:

  33. Fetal growth restriction (FGR) due to placental insufficiency is a major risk factor for stillbirth. While small-for-gestational-age (SGA; weight < 10th centile) is a commonly used proxy for FGR, detection of ...

    Authors: Lucy M. Kennedy, Stephen Tong, Alice J. Robinson, Richard J. Hiscock, Lisa Hui, Kirsten M. Dane, Anna L. Middleton, Susan P. Walker and Teresa M. MacDonald

    Citation: BMC Medicine 2020 18:395

    Content type: Research article

    Published on:

  34. Major depressive disorder (MDD) shows large heterogeneity of symptoms between patients, but within patients, particular symptom clusters may show similar trajectories. While symptom clusters and networks have ...

    Authors: K. Hebbrecht, M. Stuivenga, T. Birkenhäger, M. Morrens, E. I. Fried, B. Sabbe and E. J. Giltay

    Citation: BMC Medicine 2020 18:400

    Content type: Research article

    Published on:

  35. In pregnancy lipid levels increase with gestation resembling an atherogenic lipid profile. Currently it is unclear whether gestational lipid levels are associated with an adverse cardiovascular risk profile la...

    Authors: Maria C. Adank, Laura Benschop, Sophia P. van Streun, Anna M. Smak Gregoor, Monique T. Mulder, Eric A. P. Steegers, Sarah Schalekamp-Timmermans and Jeanine E. Roeters van Lennep

    Citation: BMC Medicine 2020 18:394

    Content type: Research article

    Published on:

  36. Colposcopy diagnosis and directed biopsy are the key components in cervical cancer screening programs. However, their performance is limited by the requirement for experienced colposcopists. This study aimed t...

    Authors: Peng Xue, Chao Tang, Qing Li, Yuexiang Li, Yu Shen, Yuqian Zhao, Jiawei Chen, Jianrong Wu, Longyu Li, Wei Wang, Yucong Li, Xiaoli Cui, Shaokai Zhang, Wenhua Zhang, Xun Zhang, Kai Ma…

    Citation: BMC Medicine 2020 18:406

    Content type: Research article

    Published on:

  37. Silent cerebral infarcts (SCIs) are the most common neurological complication in children and adults with sickle cell disease (SCD). In this systematic review, we provide an overview of studies that have detec...

    Authors: Maite E. Houwing, Rowena L. Grohssteiner, Marjolein H. G. Dremmen, Ferdows Atiq, Wichor M. Bramer, Anne P. J. de Pagter, C. Michel Zwaan, Tonya J. H. White, Meike W. Vernooij and Marjon H. Cnossen

    Citation: BMC Medicine 2020 18:393

    Content type: Research article

    Published on:

  38. The objectives of this study are to determine the effects of regularly scheduled administration of paracetamol (acetaminophen) on quality of life (QoL), discomfort, pain and neuropsychiatric symptoms of person...

    Authors: Paulien H. van Dam, Wilco P. Achterberg, Bettina S. Husebo and Monique A. A. Caljouw

    Citation: BMC Medicine 2020 18:407

    Content type: Research article

    Published on:

  39. Oral rehydration solution (ORS) is a simple intervention that can prevent childhood deaths from severe diarrhea and dehydration. In a previous study, we mapped the use of ORS treatment subnationally and found ...

    Authors: Kirsten E. Wiens, Lauren E. Schaeffer, Samba O. Sow, Babacar Ndoye, Carrie Jo Cain, Mathew M. Baumann, Kimberly B. Johnson, Paulina A. Lindstedt, Brigette F. Blacker, Zulfiqar A. Bhutta, Natalie M. Cormier, Farah Daoud, Lucas Earl, Tamer Farag, Ibrahim A. Khalil, Damaris K. Kinyoki…

    Citation: BMC Medicine 2020 18:405

    Content type: Research article

    Published on:

  40. The COVID-19 pandemic has placed significant pressure on health and social care. Survivors of COVID-19 may be left with substantial functional deficits requiring ongoing care. We aimed to determine whether pre...

    Authors: A. Vilches-Moraga, A. Price, P. Braude, L. Pearce, R. Short, A. Verduri, M. Stechman, J. T. Collins, E. Mitchell, A. G. Einarsson, S. J. Moug, T. J. Quinn, B. Stubbs, K. McCarthy, P. K. Myint, J. Hewitt…

    Citation: BMC Medicine 2020 18:408

    Content type: Research article

    Published on:

  41. The COVID-19 pandemic has placed sustained demand on health systems globally, and the capacity to provide critical care has been overwhelmed in some jurisdictions. It is unknown which triage criteria for alloc...

    Authors: Kirsten M. Fiest, Karla D. Krewulak, Kara M. Plotnikoff, Laryssa G. Kemp, Ken Kuljit S. Parhar, Daniel J. Niven, John B. Kortbeek, Henry T. Stelfox and Jeanna Parsons Leigh

    Citation: BMC Medicine 2020 18:404

    Content type: Research article

    Published on:

  42. Due to the overlapping clinical features of coronavirus disease 2019 (COVID-19) and influenza, parallels are often drawn between the two diseases. Patients with pre-existing cardiovascular diseases (CVD) are a...

    Authors: Muhammad Shahzeb Khan, Izza Shahid, Stefan D. Anker, Scott D. Solomon, Orly Vardeny, Erin D. Michos, Gregg C. Fonarow and Javed Butler

    Citation: BMC Medicine 2020 18:403

    Content type: Review

    Published on:

  • Editorial Team
  • Editorial Board
  • Call for papers
  • Editor’s choice
  • Sign up for article alerts and news from this journal
  • Contact
  • Annual Journal Metrics

  • Announcements

    medRxiv transfers

    BMC Medicine is happy to consider manuscripts that have been, or will be, posted on a preprint server. Authors are able to submit their manuscripts directly from medRxiv, without having to re-upload files.

    Portable peer review

    To reduce time spent on serial submissions and iterative reviewing, BMC Medicine offers to consider manuscripts on the basis of reviews received at other journals. We also support transfers of reviews obtained at BMC Medicine to other journals, including those outside of BMC and Springer Nature. Learn more from our portable reviews page.

    COVID-19 and impact on peer review

    As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

    Registered reports

    BMC Medicine is accepting Registered Reports. Find out more about this innovative format in our Submission Guidelines.

\