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  1. Regenerative medicine has the potential to treat genetic disorders and replace damaged or missing tissue. The use of donor or animal tissue raises many well-known issues, including limited tissue availability,...

    Authors: Alexander R. Harris, Mary Jean Walker and Frederic Gilbert
    Citation: BMC Medicine 2022 20:499
  2. Diastolic dysfunction of the left ventricle (LVDD) is equally common in elderly women and men. LVDD is a condition that can remain latent for a long time but is also held responsible for elevated left ventricu...

    Authors: A. M. L. N. van Ommen, E. Dal Canto, Maarten J. Cramer, F. H. Rutten, N. C. Onland-Moret and H. M. den Ruijter
    Citation: BMC Medicine 2022 20:496
  3. Approximately half of all women suffer from heartburn at some stage during pregnancy. The most effective treatment is proton pump inhibitors, but the safety of use during pregnancy cannot be guaranteed. This s...

    Authors: Esmee M. Breddels, Johanna Simin, Romina Fornes, Helene Lilja Engstrand, Lars Engstrand, Robin Bruyndonckx and Nele Brusselaers
    Citation: BMC Medicine 2022 20:492
  4. Leukocyte telomere length (LTL) is suggested to be a biomarker of biological age and reported to be associated with metabolic diseases such as type 2 diabetes. Glucose metabolic traits including glucose and in...

    Authors: Kwun Kiu Wong, Feifei Cheng, Cadmon K. P. Lim, Claudia H. T. Tam, Greg Tutino, Lai Yuk Yuen, Chi Chiu Wang, Yong Hou, Michael H. M. Chan, Chung Shun Ho, Mugdha V. Joglekar, Anandwardhan A. Hardikar, Alicia J. Jenkins, Boyd E. Metzger, William L. Lowe Jr., Wing Hung Tam…
    Citation: BMC Medicine 2022 20:490
  5. Human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) is still among the leading causes of disease burden and mortality in sub-Saharan Africa (SSA), and the world is not on track to m...

    Authors: Emily Haeuser, Audrey L. Serfes, Michael A. Cork, Mingyou Yang, Hedayat Abbastabar, E. S. Abhilash, Maryam Adabi, Oladimeji M. Adebayo, Victor Adekanmbi, Daniel Adedayo Adeyinka, Saira Afzal, Bright Opoku Ahinkorah, Keivan Ahmadi, Muktar Beshir Ahmed, Yonas Akalu, Rufus Olusola Akinyemi…
    Citation: BMC Medicine 2022 20:488
  6. A lack of clarity exists regarding contraceptive uptake and counselling among women with cancer, despite these women having unique family planning needs. This study aimed to systematically review the available...

    Authors: Melissa L. Harris, Tesfaye R. Feyissa, Nikola A. Bowden, Kristina Gemzell-Danielsson and Deborah Loxton
    Citation: BMC Medicine 2022 20:489
  7. Sacubitril/valsartan and angiotensin-converting enzyme inhibitor (ACEI)/angiotensin-receptor blocker (ARB) therapies were reported to affect glycaemic control and the development of diabetes mellitus (DM), but...

    Authors: Ruxin Wang, Haowen Ye, Yongting Zhao, Jinjing Wei, Ying Wang, Xiaofang Zhang and Lihong Wang
    Citation: BMC Medicine 2022 20:487
  8. Adding salt at the table is a prevalent eating habit, but its long-term relationship with cardiovascular disease (CVD) and all-cause mortality remains unclear. We evaluated the associations of adding salt at t...

    Authors: Fengping Li, Liangkai Chen, Buyun Liu, Victor W. Zhong, Yan Deng, Dan Luo, Chao Gao, Wei Bao and Shuang Rong
    Citation: BMC Medicine 2022 20:486
  9. Branched-chain amino acids (BCAAs; valine, leucine, and isoleucine) are essential amino acids that are associated with an increased risk of cardiometabolic diseases (CMD). However, there are still only limite...

    Authors: Marwah Doestzada, Daria V. Zhernakova, Inge C. L. van den Munckhof, Daoming Wang, Alexander Kurilshikov, Lianmin Chen, Vincent W. Bloks, Martijn van Faassen, Joost H. W. Rutten, Leo A. B. Joosten, Mihai G. Netea, Cisca Wijmenga, Niels P. Riksen, Alexandra Zhernakova, Folkert Kuipers and Jingyuan Fu
    Citation: BMC Medicine 2022 20:485
  10. Some observational studies had found that shift work would increase risks of metabolic disorders, cancers, and cardiovascular diseases, but there was no homogeneous evidence of such an association between shif...

    Authors: Huanquan Liao, Dong Pan, Zhenhong Deng, Jingru Jiang, Jinhua Cai, Ying Liu, Baixuan He, Ming Lei, Honghong Li, Yi Li, Yongteng Xu and Yamei Tang
    Citation: BMC Medicine 2022 20:484
  11. Plasmablastic lymphoma (PBL) is a rare but aggressive B-cell lymphoma subtype with poor prognosis. Knowledge about the etiology, clinicopathologic and molecular features, and outcomes of PBL is limited. This s...

    Authors: Di Shi, Lin Gao, Xiao-Chun Wan, Jin Li, Tian Tian, Jue Hu, Qun-Ling Zhang, Yi-Fan Su, Yu-Peng Zeng, Zi-Juan Hu, Bao-Hua Yu, Xiao-Qiu Li, Ping Wei, Ji-Wei Li and Xiao-Yan Zhou
    Citation: BMC Medicine 2022 20:483
  12. Women with premenstrual disorders (PMDs) are at increased risks of suicidal behavior and accidents. However, the effect of PMD first-line treatment on such risks have not been assessed.

    Authors: Qian Yang, Tyra Lagerberg, Arvid Sjölander, Elizabeth R. Bertone-Johnson, Fang Fang, Weimin Ye, Zheng Chang, Unnur A. Valdimarsdóttir and Donghao Lu
    Citation: BMC Medicine 2022 20:482
  13. Inhaled NO is a selective pulmonary vasodilator proven to be therapeutic for patients with pulmonary artery hypertension (PAH). The most common NO delivery system in clinical practice is cylinder-based, but un...

    Authors: Yiwei Liu, Yifan Zhu, Chenyu Jiang, Zhanhao Su, Yi Yan, Bei Feng, Wen Mao, Yuyan Zhang, Xiaojian Wang, Zhuoming Xu and Hao Zhang
    Citation: BMC Medicine 2022 20:481
  14. Liquid biopsy has been widely researched for early diagnosis, prognostication and disease monitoring in lung cancer, but there is a need to investigate its clinical utility for early-stage non-small cell lung ...

    Authors: Haifeng Shen, Yichen Jin, Heng Zhao, Manqi Wu, Kai Zhang, Zihan Wei, Xin Wang, Ziyang Wang, Yun Li, Fan Yang, Jun Wang and Kezhong Chen
    Citation: BMC Medicine 2022 20:480
  15. Clinical staging proposes that youth-onset mental disorders develop progressively, and that active treatment of earlier stages should prevent progression to more severe disorders. This retrospective cohort stu...

    Authors: William Capon, Ian B. Hickie, Mathew Varidel, Ante Prodan, Jacob J. Crouse, Joanne S. Carpenter, Shane P. Cross, Alissa Nichles, Natalia Zmicerevska, Adam J. Guastella, Elizabeth M. Scott, Jan Scott, Jai Shah and Frank Iorfino
    Citation: BMC Medicine 2022 20:479
  16. Authors: Taku Kinoshita, Masahiro Shinoda, Yasuhiro Nishizaki, Katsuya Shiraki, Yuji Hirai, Yoshiko Kichikawa, Kenji Tsushima, Masaharu Shinkai, Naoyuki Komura, Kazuo Yoshida, Yasutoshi Kido, Hiroshi Kakeya, Naoto Uemura and Junichi Kadota
    Citation: BMC Medicine 2022 20:478

    The original article was published in BMC Medicine 2022 20:342

  17. Although electroconvulsive therapy (ECT) is an effective treatment for depression, ECT cognitive impairment remains a major concern. The neurobiological underpinnings and mechanisms underlying ECT antidepressa...

    Authors: Shile Qi, Vince D. Calhoun, Daoqiang Zhang, Jeremy Miller, Zhi-De Deng, Katherine L. Narr, Yvette Sheline, Shawn M. McClintock, Rongtao Jiang, Xiao Yang, Joel Upston, Tom Jones, Jing Sui and Christopher C. Abbott
    Citation: BMC Medicine 2022 20:477
  18. Authors: Hui Jai Lee, Byuk Sung Ko, Seung Mok Ryoo, Eunah Han, Gil Joon Suh, Sung-Hyuk Choi, Sung Phil Chung, Tae Ho Lim, Won Young Kim, Woon Yong Kwon, Sung Yeon Hwang, You Hwan Jo, Jonghwan Shin, Tae Gun Shin and Kyuseok Kim
    Citation: BMC Medicine 2022 20:476

    The original article was published in BMC Medicine 2022 20:263

  19. Photodynamic therapy (PDT) has become an ideal and promising therapeutic method for fighting cancer, but its common application in clinical practice is prevented by the limitations of expensive devices in ligh...

    Authors: Xing Li, Lijiang Gu, Yuhang Chen, Xiaobing Wang, Yibo Mei, Jinlai Zhou, Minghai Ma, Jianbin Ma, Yue Chong, Xinyang Wang, Peng Guo, Dalin He and Jin Zeng
    Citation: BMC Medicine 2022 20:475
  20. Schizophrenia (SCZ) is a chronic and severe mental illness with no cure so far. Mendelian randomization (MR) is a genetic method widely used to explore etiologies of complex traits. In the current study, we ai...

    Authors: Xiaojing Gu, Meng Dou, Weiming Su, Zheng Jiang, Qingqing Duan, Bei Cao and Yongping Chen
    Citation: BMC Medicine 2022 20:474
  21. Cross-sectional studies found that frailty was associated with prevalent diabetic microvascular complications (DMC). Longitudinal evidence in this regard is inconclusive and insufficient. We aimed to prospecti...

    Authors: Yuanjue Wu, Ting Xiong, Xiao Tan and Liangkai Chen
    Citation: BMC Medicine 2022 20:473
  22. Anlotinib, a tyrosine kinase inhibitor, has shown encouraging anti-tumor activity in esophageal squamous cell carcinoma (ESCC). This study was designed to assess the efficacy and safety of anlotinib plus pacli...

    Authors: Ning Li, Tao Wu, Yong-Gui Hong, Yan-Zhen Guo, Yu-Feng Cheng, Yi-Jie Ma, Liang-Yu Bie, Dong-Hai Cui, Xiao-Hui Gao, Bing-Xu Tan, Bao-Sheng Li, Su-Xia Luo and Jun-Sheng Wang
    Citation: BMC Medicine 2022 20:472
  23. Livestock systems have been proposed as a reservoir for antimicrobial-resistant (AMR) bacteria and AMR genetic determinants that may infect or colonise humans, yet quantitative evidence regarding their epidemi...

    Authors: Dishon M. Muloi, James M. Hassell, Bryan A. Wee, Melissa J. Ward, Judy M. Bettridge, Velma Kivali, Alice Kiyong’a, Christine Ndinda, Nduhiu Gitahi, Tom Ouko, Titus Imboma, James Akoko, Maurice K. Murungi, Samuel M. Njoroge, Patrick Muinde, Lorren Alumasa…
    Citation: BMC Medicine 2022 20:471
  24. The recruitment of a sufficient number of immune cells to induce an inflamed tumor microenvironment (TME) is a prerequisite for effective response to cancer immunotherapy. The immunological phenotypes in the T...

    Authors: Yi-Han Zuo, Wei-Na Gao, Ya-Jia Xie, Sheng-Yong Yang, Jin-Tai Zhou, Hai-Hai Liang and Xing-Xing Fan
    Citation: BMC Medicine 2022 20:470
  25. Severe postoperative pain not only is a considerable burden for patients but also leads to overprescription of opioids, resulting in considerable health concerns. The remarkable development of new technologies...

    Authors: Julia Stuhlreyer, Christian Roder, Florian Krug, Christian Zöllner, Herta Flor and Regine Klinger
    Citation: BMC Medicine 2022 20:469
  26. In low- and middle-income countries, poverty and impaired growth prevent children from meeting their cognitive developmental potential. There are few studies investigating these relationships in high-income se...

    Authors: Joseph Freer, Joanna Orr, Joan K. Morris, Robert Walton, Leo Dunkel, Helen L. Storr and Andrew J. Prendergast
    Citation: BMC Medicine 2022 20:468
  27. Cardiovascular disease (CVD) is the leading cause of death in China. No previous study has reported CVD mortality at county-level, and little was known about the nonmedical ecological factors of CVD mortality ...

    Authors: Wei Wang, Junming Li, Yunning Liu, Pengpeng Ye, Chengdong Xu, Peng Yin, Jiangmei Liu, Jinlei Qi, Jinling You, Lin Lin, Ziwei Song, Limin Wang, Lijun Wang, Yong Huo and Maigeng Zhou
    Citation: BMC Medicine 2022 20:467
  28. The aim of this study is to investigate the association of retinal age gap with the risk of incident stroke and its predictive value for incident stroke.

    Authors: Zhuoting Zhu, Wenyi Hu, Ruiye Chen, Ruilin Xiong, Wei Wang, Xianwen Shang, Yifan Chen, Katerina Kiburg, Danli Shi, Shuang He, Yu Huang, Xueli Zhang, Shulin Tang, Jieshan Zeng, Honghua Yu, Xiaohong Yang…
    Citation: BMC Medicine 2022 20:466
  29. To update and internally validate a model to predict children and young people (CYP) most likely to experience long COVID (i.e. at least one impairing symptom) 3 months after SARS-CoV-2 PCR testing and to dete...

    Authors: Manjula D. Nugawela, Terence Stephenson, Roz Shafran, Bianca L. De Stavola, Shamez N. Ladhani, Ruth Simmons, Kelsey McOwat, Natalia Rojas, Emma Dalrymple, Emily Y. Cheung, Tamsin Ford, Isobel Heyman, Esther Crawley and Snehal M. Pinto Pereira
    Citation: BMC Medicine 2022 20:465
  30. Compared with patients who require fewer antihypertensive agents, those with apparent treatment-resistant hypertension (aTRH) are at increased risk for cardiovascular and all-cause mortality, independent of bl...

    Authors: Xiao Xiao, Rui Li, Cunjin Wu, Yupeng Yan, Mengmeng Yuan, Bing Cui, Yu Zhang, Channa Zhang, Xiaoxia Zhang, Weili Zhang, Rutai Hui and Yibo Wang
    Citation: BMC Medicine 2022 20:463

    The Correction to this article has been published in BMC Medicine 2022 20:491

  31. Numerous vaccine strategies are being advanced to control SARS-CoV-2, the cause of the COVID-19 pandemic. EuCorVac-19 (ECV19) is a recombinant protein nanoparticle vaccine that displays the SARS-CoV-2 receptor...

    Authors: Jonathan F. Lovell, Yeong Ok Baik, Seuk Keun Choi, Chankyu Lee, Jeong-Yoon Lee, Kazutoyo Miura, Wei-Chiao Huang, Young-Shin Park, Sun-Je Woo, Sang Hwan Seo, Jae-Ouk Kim, Manki Song, Chung-Jong Kim, Jae-Ki Choi, Jieun Kim, Eun Ju Choo…
    Citation: BMC Medicine 2022 20:462
  32. Plant-based diets assessed by a priori indices are associated with health outcomes. This study investigated the associations between pre-defined indices of plant-based diets and risk of colorectal cancer (CRC)...

    Authors: Jihye Kim, Carol J. Boushey, Lynne R. Wilkens, Christopher A. Haiman, Loïc Le Marchand and Song-Yi Park
    Citation: BMC Medicine 2022 20:430
  33. Observational studies made it possible to assess the impact of risk factors on the long-term effectiveness of mRNA and adenoviral vector (AdV) vaccines against COVID-19.

    Authors: Marek Petráš, Roman Máčalík, Daniela Janovská, Alexander M. Čelko, Jana Dáňová, Eliška Selinger, Jonáš Doleček, Sylva Neradová, Martina Franklová, Pavel Dlouhý, Jozef Rosina and Ivana Králová Lesná
    Citation: BMC Medicine 2022 20:461
  34. Smokeless tobacco use is popular in some regions worldwide, but it receives less attention compared to cigarette smoking. We aimed to estimate the recent prevalence of, and trends in, smokeless tobacco use and...

    Authors: Hui Yang, Chuanwei Ma, Min Zhao, Costan G. Magnussen and Bo Xi
    Citation: BMC Medicine 2022 20:460
  35. Young people with diabetes experience poor clinical and psychosocial outcomes, and consider the health service ill-equipped in meeting their needs. Improvements, including alternative consulting approaches, ar...

    Authors: Chrysanthi Papoutsi, Dougal Hargreaves, Ann Hagell, Natalia Hounsome, Helen Skirrow, Koteshwara Muralidhara, Grainne Colligan, Anne Ferrey, Shanti Vijayaraghavan, Trish Greenhalgh and Sarah Finer
    Citation: BMC Medicine 2022 20:459
  36. Pancreatic ductal adenocarcinoma (PDAC) has the lowest overall survival rate primarily due to the late onset of symptoms and rapid progression. Reliable and accurate tests for early detection are lacking. We a...

    Authors: Huanwen Wu, Shiwei Guo, Xiaoding Liu, Yatong Li, Zhixi Su, Qiye He, Xiaoqian Liu, Zhiwen Zhang, Lianyuan Yu, Xiaohan Shi, Suizhi Gao, Huan Wang, Yaqi Pan, Chengcheng Ma, Rui Liu, Menghua Dai…
    Citation: BMC Medicine 2022 20:458
  37. Only a few of the 34 biochemical biomarkers measured in the UK Biobank (UKB) have been associated with breast cancer, with many associations suffering from possible confounding and reverse causation. This stud...

    Authors: Sonja N. Tang, Verena Zuber and Konstantinos K. Tsilidis
    Citation: BMC Medicine 2022 20:457
  38. Supporting decisions for patients who present to the emergency department (ED) with COVID-19 requires accurate prognostication. We aimed to evaluate prognostic models for predicting outcomes in hospitalized pa...

    Authors: David van Klaveren, Theodoros P. Zanos, Jason Nelson, Todd J. Levy, Jinny G. Park, Isabel R. A. Retel Helmrich, Judith A. C. Rietjens, Melissa J. Basile, Negin Hajizadeh, Hester F. Lingsma and David M. Kent
    Citation: BMC Medicine 2022 20:456
  39. We performed phenome-wide Mendelian randomization analysis (MR-PheWAS), two-sample MR analysis, and systemic review to comprehensively explore the health effects of milk consumption in the European population.

    Authors: Shuai Yuan, Jing Sun, Ying Lu, Fengzhe Xu, Doudou Li, Fangyuan Jiang, Zhongxiao Wan, Xue Li, Li-Qiang Qin and Susanna C. Larsson
    Citation: BMC Medicine 2022 20:455
  40. Previous studies have reported that maternal smoking during pregnancy and breastfeeding may affect the occurrence of hypertension, but whether early life factors modify the impact of the offspring’s genetic ri...

    Authors: Jingjia Liang, Zuqiang Fu, Qian Liu, Yuehong Shen, Xin Zhang, Zhenkun Weng, Jin Xu, Wenxiang Li, Cheng Xu, Yong Zhou and Aihua Gu
    Citation: BMC Medicine 2022 20:454
  41. Conteltinib (CT-707) is a potent second-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor (TKI) showing promising anti-tumor activities in preclinical studies. This study aimed to assess th...

    Authors: Puyuan Xing, Qian Zhao, Li Zhang, Hanping Wang, Dingzhi Huang, Pei Hu, Yinghui Sun and Yuankai Shi
    Citation: BMC Medicine 2022 20:453
  42. Diagnostic testing has been pivotal in detecting SARS-CoV-2 infections and reducing transmission through the isolation of positive cases. We quantified the value of implementing frequent, rapid antigen (RA) te...

    Authors: Thomas N. Vilches, Ellen Rafferty, Chad R. Wells, Alison P. Galvani and Seyed M. Moghadas
    Citation: BMC Medicine 2022 20:452
  43. Glucose metabolism has been reported to be affected by dietary patterns, while the underlying mechanisms involved remain unclear. This study aimed to investigate the potential mediation role of circulating met...

    Authors: Evan Yi-Wen Yu, Zhewen Ren, Siamak Mehrkanoon, Coen D. A. Stehouwer, Marleen M. J. van Greevenbroek, Simone J. P. M. Eussen, Maurice P. Zeegers and Anke Wesselius
    Citation: BMC Medicine 2022 20:450
  44. Previous studies suggested that moderate coffee and tea consumption are associated with lower risk of mortality. However, the association between the combination of coffee and tea consumption with the risk of ...

    Authors: Yanchun Chen, Yuan Zhang, Mengnan Zhang, Hongxi Yang and Yaogang Wang
    Citation: BMC Medicine 2022 20:449
  45. Dihydroartemisinin-piperaquine (DHA-PPQ) is an alternative first-line antimalarial to artemether-lumefantrine in Kenya. However, recent reports on the emergence of PPQ resistance in Southeast Asia threaten its...

    Authors: Dancan M. Wakoli, Bartholomew N. Ondigo, Douglas O. Ochora, Joseph G. Amwoma, Winnie Okore, Edwin W. Mwakio, Gladys Chemwor, Jackeline Juma, Raphael Okoth, Charles Okudo, Redemptah Yeda, Benjamin H. Opot, Agnes C. Cheruiyot, Dennis Juma, Amanda Roth, Benhards R. Ogutu…
    Citation: BMC Medicine 2022 20:448
  46. Preterm birth may affect maternal mental health, yet most studies focus on postpartum mental disorders only. We explored the relationship between preterm delivery and the long-term risk of maternal hospitaliza...

    Authors: Gabriel Côté-Corriveau, Gilles Paradis, Thuy Mai Luu, Aimina Ayoub, Marianne Bilodeau-Bertrand and Nathalie Auger
    Citation: BMC Medicine 2022 20:447
  47. The progression of motor and non-motor symptoms (NMS) and the sensitivity of each item of the Unified Multiple System Atrophy Rating Scale (UMSARS) to change remain unclear in Chinese patients with early-stage...

    Authors: Lingyu Zhang, Yanbing Hou, Bei Cao, Qianqian Wei, Ruwei Ou, Kuncheng Liu, Junyu Lin, Tianmi Yang, Yi Xiao, Yongping Chen, Wei Song, Bi Zhao and Huifang Shang
    Citation: BMC Medicine 2022 20:446