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  1. Research article

    Resisting and tolerating P. falciparum in pregnancy under different malaria transmission intensities

    Resistance and tolerance to Plasmodium falciparum can determine the progression of malaria disease. However, quantitative evidence of tolerance is still limited. We investigated variations in the adverse impact o...

    Nicaise Tuikue Ndam, Emmanuel Mbuba, Raquel González, Pau Cisteró, Simon Kariuki, Esperança Sevene, María Rupérez, Ana Maria Fonseca, Anifa Vala, Sonia Maculuve, Alfons Jiménez, Llorenç Quintó, Peter Ouma, Michael Ramharter, John J. Aponte, Arsenio Nhacolo…

    BMC Medicine 2017 15:130

    Published on: 17 July 2017

  2. Research article

    The prognostic value of lymph node yield in the earliest stage of colorectal cancer: a multicenter cohort study

    In patients with stage II colorectal cancer (CRC) the number of surgically retrieved lymph nodes (LNs) is associated with prognosis, resulting in a minimum of 10–12 retrieved LNs being recommended for this sta...

    Yara Backes, Sjoerd G. Elias, Bibie S. Bhoelan, John N. Groen, Jeroen van Bergeijk, Tom C. J. Seerden, Hendrikus J. M. Pullens, Bernhard W. M. Spanier, Joost M. J. Geesing, Koen Kessels, Marjon Kerkhof, Peter D. Siersema, Wouter H. de Vos tot Nederveen Cappel, Niels van Lelyveld, Frank H. J. Wolfhagen, Frank ter Borg…

    BMC Medicine 2017 15:129

    Published on: 14 July 2017

  3. Research article

    Tall height and obesity are associated with an increased risk of aggressive prostate cancer: results from the EPIC cohort study

    The relationship between body size and prostate cancer risk, and in particular risk by tumour characteristics, is not clear because most studies have not differentiated between high-grade or advanced stage tum...

    Aurora Perez-Cornago, Paul N. Appleby, Tobias Pischon, Konstantinos K. Tsilidis, Anne Tjønneland, Anja Olsen, Kim Overvad, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Annika Steffen, Antonia Trichopoulou, Pagona Lagiou, Maria Kritikou, Vittorio Krogh, Domenico Palli…

    BMC Medicine 2017 15:115

    Published on: 13 July 2017

  4. Research article

    A nurse-delivered, clinic-based intervention to address intimate partner violence among low-income women in Mexico City: findings from a cluster randomized controlled trial

    Rigorous evaluations of health sector interventions addressing intimate partner violence (IPV) in low- and middle-income countries are lacking. We aimed to assess whether an enhanced nurse-delivered interventi...

    Jhumka Gupta, Kathryn L. Falb, Oriana Ponta, Ziming Xuan, Paola Abril Campos, Annabel Arellano Gomez, Jimena Valades, Gisele Cariño and Claudia Diaz Olavarrieta

    BMC Medicine 2017 15:128

    Published on: 12 July 2017

  5. Research article

    Can China achieve a one-third reduction in premature mortality from non-communicable diseases by 2030?

    The United Nation’s Sustainable Development Goals for 2030 include reducing premature mortality from non-communicable diseases (NCDs) by one third. To assess the feasibility of this goal in China, we projected...

    Yichong Li, Xinying Zeng, Jiangmei Liu, Yunning Liu, Shiwei Liu, Peng Yin, Jinlei Qi, Zhenping Zhao, Shicheng Yu, Yuehua Hu, Guangxue He, Alan D. Lopez, George F. Gao, Linhong Wang and Maigeng Zhou

    BMC Medicine 2017 15:132

    Published on: 11 July 2017

  6. Commentary

    Rapidly increasing end-of-life care needs: a timely warning

    Current trends in population ageing show that, in the near future, while more people will live longer, more will also die at any one time. Health systems, as well as individual practitioners, are only just bec...

    Geoffrey Mitchell

    BMC Medicine 2017 15:126

    Published on: 10 July 2017

  7. Research article

    Use of malaria rapid diagnostic tests by community health workers in Afghanistan: cluster randomised trial

    The World Health Organisation (WHO) recommends parasitological diagnosis of malaria before treatment, but use of malaria rapid diagnostic tests (mRDTs) by community health workers (CHWs) has not been fully tes...

    Toby Leslie, Mark Rowland, Amy Mikhail, Bonnie Cundill, Barbara Willey, Asif Alokozai, Ismail Mayan, Anwar Hasanzai, Sayed Habibullah Baktash, Nader Mohammed, Molly Wood, Habib-u-Rahman Rahimi, Baptiste Laurent, Cyril Buhler and Christopher J. M. Whitty

    BMC Medicine 2017 15:124

    Published on: 7 July 2017

  8. Research article

    Pre-diagnostic metabolite concentrations and prostate cancer risk in 1077 cases and 1077 matched controls in the European Prospective Investigation into Cancer and Nutrition

    Little is known about how pre-diagnostic metabolites in blood relate to risk of prostate cancer. We aimed to investigate the prospective association between plasma metabolite concentrations and risk of prostat...

    Julie A. Schmidt, Georgina K. Fensom, Sabina Rinaldi, Augustin Scalbert, Paul N. Appleby, David Achaintre, Audrey Gicquiau, Marc J. Gunter, Pietro Ferrari, Rudolf Kaaks, Tilman Kühn, Anna Floegel, Heiner Boeing, Antonia Trichopoulou, Pagona Lagiou, Eleutherios Anifantis…

    BMC Medicine 2017 15:122

    Published on: 5 July 2017

  9. Research article

    Diagnostic delay for giant cell arteritis – a systematic review and meta-analysis

    Giant cell arteritis (GCA), if untreated, can lead to blindness and stroke. The study’s objectives were to (1) determine a new evidence-based benchmark of the extent of diagnostic delay for GCA and (2) examine...

    James A. Prior, Hoda Ranjbar, John Belcher, Sarah L. Mackie, Toby Helliwell, Jennifer Liddle and Christian D. Mallen

    BMC Medicine 2017 15:120

    Published on: 28 June 2017

  10. Commentary

    About the practice of psychiatric euthanasia: a commentary

    Euthanasia motivated by mental disorders is legal in only a few countries and has a short history. In a recent report of all psychiatric euthanasia cases in Belgium between 2002 and 2013, Dierickx and colleagu...

    Jorge Lopez-Castroman

    BMC Medicine 2017 15:125

    Published on: 27 June 2017

  11. Research article

    Overcoming intratumoural heterogeneity for reproducible molecular risk stratification: a case study in advanced kidney cancer

    Metastatic clear cell renal cell cancer (mccRCC) portends a poor prognosis and urgently requires better clinical tools for prognostication as well as for prediction of response to treatment. Considerable inves...

    Alexander L. R. Lubbock, Grant D. Stewart, Fiach C. O’Mahony, Alexander Laird, Peter Mullen, Marie O’Donnell, Thomas Powles, David J. Harrison and Ian M. Overton

    BMC Medicine 2017 15:118

    Published on: 26 June 2017

  12. Research article

    Methylome analysis of extreme chemoresponsive patients identifies novel markers of platinum sensitivity in high-grade serous ovarian cancer

    Despite an early response to platinum-based chemotherapy in advanced stage high-grade serous ovarian cancer (HGSOC), the majority of patients will relapse with drug-resistant disease. Aberrant epigenetic alter...

    Tushar Tomar, Nicolette G. Alkema, Leroy Schreuder, Gert Jan Meersma, Tim de Meyer, Wim van Criekinge, Harry G. Klip, Heidi Fiegl, Els van Nieuwenhuysen, Ignace Vergote, Martin Widschwendter, Ed Schuuring, Ate G. J. van der Zee, Steven de Jong and G. Bea A. Wisman

    BMC Medicine 2017 15:116

    Published on: 23 June 2017

  13. Research article

    Influence of the number and timing of malaria episodes during pregnancy on prematurity and small-for-gestational-age in an area of low transmission

    Most evidence on the association between malaria in pregnancy and adverse pregnancy outcomes focuses on falciparum malaria detected at birth. We assessed the association between the number and timing of falcip...

    Kerryn A. Moore, Julie A. Simpson, Jacher Wiladphaingern, Aung Myat Min, Mupawjay Pimanpanarak, Moo Kho Paw, Jathee Raksuansak, Sasithon Pukrittayakamee, Freya J. I. Fowkes, Nicholas J. White, François Nosten and Rose McGready

    BMC Medicine 2017 15:117

    Published on: 21 June 2017

  14. Research article

    The effect of weekly specialist palliative care teleconsultations in patients with advanced cancer –a randomized clinical trial

    Teleconsultation seems to be a promising intervention for providing palliative care to home-dwelling patients; however, its effect on clinically relevant outcome measures remains largely unexplored. Therefore,...

    Patrick D. Hoek, Henk J. Schers, Ewald M. Bronkhorst, Kris C. P. Vissers and Jeroen G. J. Hasselaar

    BMC Medicine 2017 15:119

    Published on: 19 June 2017

  15. Research article

    Synergistic effect of IL-12 and IL-18 induces TIM3 regulation of γδ T cell function and decreases the risk of clinical malaria in children living in Papua New Guinea

    γδ T cells are important for both protective immunity and immunopathogenesis during malaria infection. However, the immunological processes determining beneficial or detrimental effects on disease outcome rema...

    Louis Schofield, Lisa J. Ioannidis, Stephan Karl, Leanne J. Robinson, Qiao Y. Tan, Daniel P. Poole, Inoni Betuela, Danika L. Hill, Peter M. Siba, Diana S. Hansen, Ivo Mueller and Emily M. Eriksson

    BMC Medicine 2017 15:114

    Published on: 15 June 2017

  16. Research article

    Recent household transmission of tuberculosis in England, 2010–2012: retrospective national cohort study combining epidemiological and molecular strain typing data

    We estimate the proportion of tuberculosis (TB) in England due to recent household transmission, identify factors associated with being a household transmitter, and investigate the impact that identification o...

    Maeve K. Lalor, Laura F. Anderson, Esther L. Hamblion, Andy Burkitt, Jennifer A. Davidson, Helen Maguire, Ibrahim Abubakar and H. Lucy Thomas

    BMC Medicine 2017 15:105

    Published on: 13 June 2017

  17. Research article

    Assessing the efficiency of catch-up campaigns for the introduction of pneumococcal conjugate vaccine: a modelling study based on data from PCV10 introduction in Kilifi, Kenya

    The World Health Organisation recommends the use of catch-up campaigns as part of the introduction of pneumococcal conjugate vaccines (PCVs) to accelerate herd protection and hence PCV impact. The value of a c...

    Stefan Flasche, John Ojal, Olivier Le Polain de Waroux, Mark Otiende, Katherine L. O’Brien, Moses Kiti, D. James Nokes, W John Edmunds and J. Anthony G. Scott

    BMC Medicine 2017 15:113

    Published on: 7 June 2017

  18. Research article

    Comprehensive DNA methylation study identifies novel progression-related and prognostic markers for cutaneous melanoma

    Cutaneous melanoma is the deadliest skin cancer, with an increasing incidence and mortality rate. Currently, staging of patients with primary melanoma is performed using histological biomarkers such as tumor t...

    Jasper Wouters, Miguel Vizoso, Anna Martinez-Cardus, F. Javier Carmona, Olivier Govaere, Teresa Laguna, Jesuchristopher Joseph, Peter Dynoodt, Claudia Aura, Mona Foth, Roy Cloots, Karin van den Hurk, Balazs Balint, Ian G. Murphy, Enda W. McDermott, Kieran Sheahan…

    BMC Medicine 2017 15:101

    Published on: 5 June 2017

  19. Research article

    Number needed to treat (NNT) in clinical literature: an appraisal

    The number needed to treat (NNT) is an absolute effect measure that has been used to assess beneficial and harmful effects of medical interventions. Several methods can be used to calculate NNTs, and they shou...

    Diogo Mendes, Carlos Alves and Francisco Batel-Marques

    BMC Medicine 2017 15:112

    Published on: 1 June 2017

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