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  1. Content type: Correspondence

    Adaptive designs can make clinical trials more flexible by utilising results accumulating in the trial to modify the trial’s course in accordance with pre-specified rules. Trials with an adaptive design are of...

    Authors: Philip Pallmann, Alun W. Bedding, Babak Choodari-Oskooei, Munyaradzi Dimairo, Laura Flight, Lisa V. Hampson, Jane Holmes, Adrian P. Mander, Lang’o Odondi, Matthew R. Sydes, Sofía S. Villar, James M. S. Wason, Christopher J. Weir, Graham M. Wheeler, Christina Yap and Thomas Jaki

    Citation: BMC Medicine 2018 16:29

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  2. Content type: Research article

    Despite long-lasting HIV replication control, a significant proportion of elite controller (EC) patients may experience CD4 T-cell loss. Discovering perturbations in immunological parameters could help our und...

    Authors: José M. Benito, María C. Ortiz, Agathe León, Luis A. Sarabia, José M. Ligos, María Montoya, Marcial Garcia, Ezequiel Ruiz-Mateos, Rosario Palacios, Alfonso Cabello, Clara Restrepo, Carmen Rodriguez, Jorge del Romero, Manuel Leal, María A. Muñoz-Fernández, José Alcamí…

    Citation: BMC Medicine 2018 16:30

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  3. Content type: Research article

    The purpose of this study is to validate a new five-tiered prognostic classification system to better discriminate cancer-specific mortality in men diagnosed with primary non-metastatic prostate cancer.

    Authors: V. J. Gnanapragasam, O. Bratt, K. Muir, L. S. Lee, H. H. Huang, P. Stattin and A. Lophatananon

    Citation: BMC Medicine 2018 16:31

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  4. Content type: Research article

    Depression is viewed as a major and increasing public health issue, as it causes high distress in the people experiencing it and considerable financial costs to society. Efforts are being made to reduce this b...

    Authors: Anna Fernández, Juan M. Mendive, Sonia Conejo-Cerón, Patricia Moreno-Peral, Michael King, Irwin Nazareth, Carlos Martín-Pérez, Carmen Fernández-Alonso, Antonina Rodríguez-Bayón, Jose Maria Aiarzaguena, Carmen Montón-Franco, Antoni Serrano-Blanco, Inmaculada Ibañez-Casas, Emiliano Rodríguez-Sánchez, Luis Salvador-Carulla, Paola Bully Garay…

    Citation: BMC Medicine 2018 16:28

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  5. Content type: Research article

    Multidrug-resistant tuberculosis (MDR-TB) is a growing concern in meeting global targets for TB control. In high-income low-TB-incidence countries, a disproportionate number of MDR-TB cases occur in migrant (f...

    Authors: Laura B. Nellums, Kieran Rustage, Sally Hargreaves and Jon S. Friedland

    Citation: BMC Medicine 2018 16:27

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  6. Content type: Research article

    The ability to reproduce experiments is a defining principle of science. Reproducibility of clinical research has received relatively little scientific attention. However, it is important as it may inform clin...

    Authors: Daniel J. Niven, T. Jared McCormick, Sharon E. Straus, Brenda R. Hemmelgarn, Lianne Jeffs, Tavish R. M. Barnes and Henry T. Stelfox

    Citation: BMC Medicine 2018 16:26

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  7. Content type: Commentary

    Adult-onset, or type II diabetes mellitus (T2DM) has a complex genetic architecture, from hundreds of genes with low penetrance, common susceptibility variants (e.g., TCF7L2), to a set of more than ten genes that...

    Authors: Leslie G. Biesecker

    Citation: BMC Medicine 2018 16:25

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    The original article was published in BMC Medicine 2017 15:213

  8. Content type: Research article

    Dysfunction of the circadian clock and single polymorphisms of some circadian genes have been linked to cancer susceptibility, although data are scarce and findings inconsistent. We aimed to investigate the as...

    Authors: Simone Mocellin, Saveria Tropea, Clara Benna and Carlo Riccardo Rossi

    Citation: BMC Medicine 2018 16:20

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  9. Content type: Commentary

    The therapeutic approach for the second-line treatment of patients with advanced non-small cell lung cancer (NSCLC) without actionable mutations has been revolutionized by the recent approval of new effective ...

    Authors: Alessandro Morabito

    Citation: BMC Medicine 2018 16:24

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    The original article was published in BMC Medicine 2017 15:193

  10. Content type: Research article

    Primary care provides the foundation for most modern health-care systems, and in the interests of equity, it should be resourced according to local need. We aimed to describe spatially the burden of chronic co...

    Authors: Evangelos Kontopantelis, Mamas A. Mamas, Harm van Marwijk, Andrew M. Ryan, Peter Bower, Bruce Guthrie and Tim Doran

    Citation: BMC Medicine 2018 16:19

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  11. Content type: Research article

    Comparisons of clinical trial findings in systematic reviews can be hindered by the heterogeneity of the outcomes reported. Moreover, the outcomes that matter most to patients might be underreported. A core ou...

    Authors: Jean-Baptiste Beuscart, Wilma Knol, Shane Cullinan, Claudio Schneider, Olivia Dalleur, Benoit Boland, Stefanie Thevelin, Paul A. F. Jansen, Denis O’Mahony, Nicolas Rodondi and Anne Spinewine

    Citation: BMC Medicine 2018 16:21

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  12. Content type: Research article

    Human fetal adrenal glands are highly active and, with the placenta, regulate circulating progesterone, estrogen and corticosteroids in the fetus. At birth the adrenals are essential for neonate salt retention...

    Authors: Zoe C. Johnston, Michelle Bellingham, Panagiotis Filis, Ugo Soffientini, Denise Hough, Siladitya Bhattacharya, Marc Simard, Geoffrey L. Hammond, Peter King, Peter J. O’Shaughnessy and Paul A. Fowler

    Citation: BMC Medicine 2018 16:23

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  13. Content type: Research article

    The seven-valent pneumococcal conjugate vaccine (PCV) was introduced in England in September 2006, changing to the 13-valent vaccine in April 2010. PCV impact on invasive pneumococcal disease (IPD) has been ex...

    Authors: Dominic Thorrington, Nick Andrews, Julia Stowe, Elizabeth Miller and Albert Jan van Hoek

    Citation: BMC Medicine 2018 16:13

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  14. Content type: Research article

    Women who experience menopause are at higher cardiometabolic risk and often display adverse changes in metabolic biomarkers compared with pre-menopausal women. It remains elusive whether the changes in cardiom...

    Authors: Qin Wang, Diana L. Santos Ferreira, Scott M. Nelson, Naveed Sattar, Mika Ala-Korpela and Debbie A. Lawlor

    Citation: BMC Medicine 2018 16:17

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  15. Content type: Research article

    Our aims were to evaluate critically the evidence from systematic reviews as well as narrative reviews of the effects of melatonin (MLT) on health and to identify the potential mechanisms of action involved.

    Authors: Pawel P. Posadzki, Ram Bajpai, Bhone Myint Kyaw, Nicola J. Roberts, Amnon Brzezinski, George I. Christopoulos, Ushashree Divakar, Shweta Bajpai, Michael Soljak, Gerard Dunleavy, Krister Jarbrink, Ei Ei Khaing Nang, Chee Kiong Soh and Josip Car

    Citation: BMC Medicine 2018 16:18

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  16. Content type: Research article

    The year 2016 has marked the highest number of displaced people worldwide on record. A large number of these refugees are women, yet little is known about their specific situation and the hurdles they have to ...

    Authors: Jenny Jesuthasan, Ekin Sönmez, Ingar Abels, Christine Kurmeyer, Jana Gutermann, Renate Kimbel, Antje Krüger, Guenter Niklewski, Kneginja Richter, Ulrich Stangier, Anja Wollny, Ulrike Zier, Sabine Oertelt-Prigione and Meryam Shouler-Ocak

    Citation: BMC Medicine 2018 16:15

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  17. Content type: Research article

    The built environment influences behaviour, like physical activity, diet and sleep, which affects the risk of type 2 diabetes mellitus (T2DM). This study systematically reviewed and meta-analysed evidence on t...

    Authors: N. R. den Braver, J. Lakerveld, F. Rutters, L. J. Schoonmade, J. Brug and J. W. J. Beulens

    Citation: BMC Medicine 2018 16:12

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  18. Content type: Research article

    National guidance on preventing type 2 diabetes mellitus (T2DM) in the UK recommends low-intensity lifestyle interventions for individuals with intermediate categories of hyperglycaemia defined in terms of imp...

    Authors: Samantha Roberts, Dawn Craig, Amanda Adler, Klim McPherson and Trisha Greenhalgh

    Citation: BMC Medicine 2018 16:16

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  19. Content type: Research article

    Rotavirus causes severe gastroenteritis in infants and young children worldwide. The UK introduced the monovalent rotavirus vaccine (Rotarix®) in July 2013. Vaccination is free of charge to parents, with two d...

    Authors: Daniel Hungerford, Roberto Vivancos, Jonathan M. Read, Miren Iturriza-Gόmara, Neil French and Nigel A. Cunliffe

    Citation: BMC Medicine 2018 16:10

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  20. Content type: Debate

    Disability as a health outcome deserves more attention than it has so far received. With people living longer and the epidemiological transition from infectious to noncommunicable diseases as the major cause o...

    Authors: Alarcos Cieza, Carla Sabariego, Jerome Bickenbach and Somnath Chatterji

    Citation: BMC Medicine 2018 16:14

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  21. Content type: Research article

    Preterm prelabour rupture of the fetal membranes (PPROM) precedes 30% of preterm births and is a risk factor for early onset neonatal sepsis. As PPROM is strongly associated with ascending vaginal infection, p...

    Authors: Richard G. Brown, Julian R. Marchesi, Yun S. Lee, Ann Smith, Benjamin Lehne, Lindsay M. Kindinger, Vasso Terzidou, Elaine Holmes, Jeremy K. Nicholson, Phillip R. Bennett and David A. MacIntyre

    Citation: BMC Medicine 2018 16:9

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  22. Content type: Commentary

    In 2016, the World Health Organization (WHO) recommended point-of-use fortification of complementary foods with iron-containing micronutrient powders to improve iron status and reduce anaemia in children at ri...

    Authors: Hans Verhoef, Emily Teshome and Andrew M. Prentice

    Citation: BMC Medicine 2018 16:7

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    The original article was published in BMC Medicine 2017 15:99

    The original article was published in BMC Medicine 2017 15:89

  23. Content type: Research article

    In 2012, the World Health Organization recommended blocking the transmission of Plasmodium falciparum with single low-dose primaquine (SLDPQ, target dose 0.25 mg base/kg body weight), without testing for glucose-...

    Authors: W. Robert Taylor, Htee Khu Naw, Kathryn Maitland, Thomas N. Williams, Melissa Kapulu, Umberto D’Alessandro, James A. Berkley, Philip Bejon, Joseph Okebe, Jane Achan, Alfred Ngwa Amambua, Muna Affara, Davis Nwakanma, Jean-Pierre van Geertruyden, Muhindo Mavoko, Pascal Lutumba…

    Citation: BMC Medicine 2018 16:11

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