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  1. Current methods for cervical cancer screening result in an increased number of referrals and unnecessary diagnostic procedures. This study aimed to develop and evaluate a more accurate model for cervical cance...

    Authors: Zeni Wu, Tingyuan Li, Yongli Han, Mingyue Jiang, Yanqin Yu, Huifang Xu, Lulu Yu, Jianfeng Cui, Bin Liu, Feng Chen, Jian Yin, Xun Zhang, Qinjing Pan, Youlin Qiao and Wen Chen

    Citation: BMC Medicine 2021 19:197

    Content type: Research article

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  2. Bacterial vaginosis (BV) is the most common vaginal dysbiosis to affect women globally, yet an unacceptably high proportion of women experience BV recurrence within 6 months of recommended antibiotic therapy. ...

    Authors: Lenka A. Vodstrcil, Christina A. Muzny, Erica L. Plummer, Jack D. Sobel and Catriona S. Bradshaw

    Citation: BMC Medicine 2021 19:194

    Content type: Review

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  3. Triple-negative breast cancer (TNBC) is a clinically aggressive disease with abundant variants that cause homologous recombination repair deficiency (HRD). Whether TNBC patients with HRD are sensitive to anthr...

    Authors: Gaoming Liao, Zedong Jiang, Yiran Yang, Cong Zhang, Meiting Jiang, Jiali Zhu, Liwen Xu, Aimin Xie, Min Yan, Yunpeng Zhang, Yun Xiao and Xia Li

    Citation: BMC Medicine 2021 19:190

    Content type: Research article

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  4. Anticoagulation for stroke prevention in atrial fibrillation (AF) has, historically, been under-used in older people. The aim of this study was to investigate prescribing of oral anticoagulants (OACs) for peop...

    Authors: Anneka Mitchell, Julia Snowball, Tomas J. Welsh, Margaret C. Watson and Anita McGrogan

    Citation: BMC Medicine 2021 19:189

    Content type: Research article

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  5. The literature paints a complex picture of the association between mortality risk and ICU strain.

    Authors: Harrison Wilde, Thomas Mellan, Iwona Hawryluk, John M. Dennis, Spiros Denaxas, Christina Pagel, Andrew Duncan, Samir Bhatt, Seth Flaxman, Bilal A. Mateen and Sebastian J. Vollmer

    Citation: BMC Medicine 2021 19:213

    Content type: Research article

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  6. This study applies an umbrella review approach to summarise the global evidence on the risk of severe COVID-19 outcomes in patients with pre-existing health conditions.

    Authors: Marina Treskova-Schwarzbach, Laura Haas, Sarah Reda, Antonia Pilic, Anna Borodova, Kasra Karimi, Judith Koch, Teresa Nygren, Stefan Scholz, Viktoria Schönfeld, Sabine Vygen-Bonnet, Ole Wichmann and Thomas Harder

    Citation: BMC Medicine 2021 19:212

    Content type: Research article

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  7. Emergence of more transmissible SARS-CoV-2 variants requires more efficient control measures to limit nosocomial transmission and maintain healthcare capacities during pandemic waves. Yet the relative importan...

    Authors: Thi Mui Pham, Hannan Tahir, Janneke H. H. M. van de Wijgert, Bastiaan R. Van der Roest, Pauline Ellerbroek, Marc J. M. Bonten, Martin C. J. Bootsma and Mirjam E. Kretzschmar

    Citation: BMC Medicine 2021 19:211

    Content type: Research article

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  8. Impaired orthostatic blood pressure response and syncope confer a high risk of falls and trauma. The relationship between a history of unexplained syncope and orthostatic hypotension (OH) with subsequent fract...

    Authors: Madeleine Johansson, Cecilia Rogmark, Richard Sutton, Artur Fedorowski and Viktor Hamrefors

    Citation: BMC Medicine 2021 19:188

    Content type: Research article

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  9. The optimal posttreatment surveillance strategy for nasopharyngeal carcinoma (NPC) remains unclear. Circulating cell-free Epstein-Barr virus (cfEBV) DNA has been recognized as a promising biomarker to facilita...

    Authors: Chen-Fei Wu, Li Lin, Yan-Ping Mao, Bin Deng, Jia-Wei Lv, Wei-Hong Zheng, Dan-Wan Wen, Jia Kou, Fo-Ping Chen, Xing-Li Yang, Si-Si Xu, Jun Ma, Guan-Qun Zhou and Ying Sun

    Citation: BMC Medicine 2021 19:193

    Content type: Research article

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  10. Schizophrenia and bipolar disorder are severe mental illnesses which are highly prevalent worldwide. Risperidone and Paliperidone are treatments for either illnesses, but their efficacy compared to other antip...

    Authors: Alexander Hodkinson, Carl Heneghan, Kamal R. Mahtani, Evangelos Kontopantelis and Maria Panagioti

    Citation: BMC Medicine 2021 19:195

    Content type: Research article

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  11. The pathogenesis of malaria in pregnancy (MiP) involves accumulation of P. falciparum-infected red blood cells (pRBCs) in the placenta, contributing to poor pregnancy outcomes. Parasite accumulation is primarily ...

    Authors: D. Herbert Opi, Michelle J. Boyle, Alistair R. D. McLean, Linda Reiling, Jo-Anne Chan, Danielle I. Stanisic, Alice Ura, Ivo Mueller, Freya J. I. Fowkes, Stephen J. Rogerson and James G. Beeson

    Citation: BMC Medicine 2021 19:201

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2021 19:231

  12. Coronavirus SARS-CoV-2, the causative agent of COVID-19, has caused a still evolving global pandemic. Given the worldwide vaccination campaign, the understanding of the vaccine-induced versus COVID-19-induced ...

    Authors: Ioannis P. Trougakos, Evangelos Terpos, Christina Zirou, Aimilia D. Sklirou, Filia Apostolakou, Sentiljana Gumeni, Ioanna Charitaki, Eleni-Dimitra Papanagnou, Tina Bagratuni, Christine-Ivy Liacos, Andreas Scorilas, Eleni Korompoki, Ioannis Papassotiriou, Efstathios Kastritis and Meletios A. Dimopoulos

    Citation: BMC Medicine 2021 19:208

    Content type: Research article

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  13. Although the pathophysiology of cognitive decline is multifactorial, and modifiable by lifestyle, the evidence for the role of diet on cognitive function is still accumulating, particularly the potentially pre...

    Authors: Amy Jennings, Claire J. Steves, Alexander Macgregor, Tim Spector and Aedín Cassidy

    Citation: BMC Medicine 2021 19:185

    Content type: Research article

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  14. Authors: Terence J. Quin, Jennifer K. Burton, Ben Carter, Nicola Cooper, Kerry Dwan, Ryan Field, Suzane C. Freeman, Claudia Gue, Ping-Hsuan Hsieh, Kris McGill, Clareece R. Nevill, Dikshyanta Rana, Alex Sutton, Martin Taylor Rowan and Yiqiao Xin

    Citation: BMC Medicine 2021 19:207

    Content type: Correction

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    The original article was published in BMC Medicine 2021 19:46

  15. Type 2 diabetes (T2D) is common and increasing in prevalence. It is possible to prevent or delay T2D using lifestyle intervention programmes. Entry to these programmes is usually determined by a measure of gly...

    Authors: Lauren R. Rodgers, Anita V. Hill, John M. Dennis, Zoe Craig, Benedict May, Andrew T. Hattersley, Timothy J. McDonald, Rob C. Andrews, Angus Jones and Beverley M. Shields

    Citation: BMC Medicine 2021 19:184

    Content type: Research article

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  16. The purpose of this trial was to test if the Norfolk Diabetes Prevention Study (NDPS) lifestyle intervention, recently shown to reduce the incidence of type 2 diabetes in high-risk groups, also improved glycae...

    Authors: Michael Sampson, Allan Clark, Max Bachmann, Nikki Garner, Lisa Irvine, Amanda Howe, Colin Greaves, Sara Auckland, Jane Smith, Jeremy Turner, Dave Rea, Gerry Rayman, Ketan Dhatariya, W. Garry John, Garry Barton, Rebecca Usher…

    Citation: BMC Medicine 2021 19:183

    Content type: Research article

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  17. The use of proactive genetic screening for disease prevention and early detection is not yet widespread. Professional practice guidelines from the American College of Medical Genetics and Genomics (ACMG) have ...

    Authors: Eden V. Haverfield, Edward D. Esplin, Sienna J. Aguilar, Kathryn E. Hatchell, Kelly E. Ormond, Andrea Hanson-Kahn, Paldeep S. Atwal, Sarah Macklin-Mantia, Stephanie Hines, Caron W.-M. Sak, Steven Tucker, Steven B. Bleyl, Peter J. Hulick, Ora K. Gordon, Lea Velsher, Jessica Y. J. Gu…

    Citation: BMC Medicine 2021 19:199

    Content type: Research article

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  18. Preventing unintended pregnancies is paramount for women living with HIV (WLHIV). Previous studies have suggested that efavirenz-containing antiretroviral therapy (ART) reduces contraceptive effectiveness of i...

    Authors: Rena C. Patel, Gustavo Amorim, Beatrice Jakait, Bryan E. Shepherd, A. Rain Mocello, Beverly Musick, Caitlin Bernard, Maricianah Onono, Elizabeth A. Bukusi, Kara Wools-Kaloustian, Craig R. Cohen and Constantin T. Yiannoutsos

    Citation: BMC Medicine 2021 19:178

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2021 19:192

  19. The COVID-19 pandemic has disrupted the delivery of immunisation services globally. Many countries have postponed vaccination campaigns out of concern about infection risks to the staff delivering vaccination,...

    Authors: Simon R. Procter, Kaja Abbas, Stefan Flasche, Ulla Griffiths, Brittany Hagedorn, Kathleen M. O’Reilly and Mark Jit

    Citation: BMC Medicine 2021 19:198

    Content type: Research article

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  20. Over 200 schizophrenia risk loci have been identified by genome-wide association studies (GWASs). However, the majority of risk loci were identified in populations of European ancestry (EUR), potentially missi...

    Authors: Jiewei Liu, Shiwu Li, Xiaoyan Li, Wenqiang Li, Yongfeng Yang, Suqin Guo, Luxian Lv, Xiao Xiao, Yong-Gang Yao, Fanglin Guan, Ming Li and Xiong-Jian Luo

    Citation: BMC Medicine 2021 19:177

    Content type: Research article

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  21. Globally, Haemophilus influenzae type b (Hib) vaccine has substantially reduced the burden of Hib invasive disease. However, China remains the only country not to include Hib vaccine into its national immunizatio...

    Authors: Haijun Zhang, Cristina Garcia, Wenzhou Yu, Maria Deloria Knoll, Xiaozhen Lai, Tingting Xu, Rize Jing, Ying Qin, Zundong Yin, Brian Wahl and Hai Fang

    Citation: BMC Medicine 2021 19:181

    Content type: Research article

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  22. Patients with atrial fibrillation (AF) complicated by heart failure (HF) have a poor prognosis. We investigated whether long term loop-diuretic therapy in patients with AF and no known diagnosis of HF, as a po...

    Authors: Rosita Zakeri, Ann D. Morgan, Varun Sundaram, Chloe Bloom, John G. F. Cleland and Jennifer K. Quint

    Citation: BMC Medicine 2021 19:179

    Content type: Research article

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  23. Knowledge about the 1-year outcome of COVID-19 is limited. The aim of this study was to follow-up and evaluate lung abnormalities on serial computed tomography (CT) scans in patients with COVID-19 after hospit...

    Authors: Yanfei Chen, Cheng Ding, Ling Yu, Wanru Guo, Xuewen Feng, Liang Yu, Junwei Su, Ting Xu, Cheng Ren, Ding Shi, Wenrui Wu, Ping Yi, Jun Liu, Jingjing Tao, Guanjing Lang, Yongtao Li…

    Citation: BMC Medicine 2021 19:191

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2021 19:200

  24. Adverse childhood experiences (ACEs) are negatively associated with a range of child health outcomes. In this study, we explored associations between five individual ACEs and child mental health diagnoses or s...

    Authors: Emily Lowthian, Rebecca Anthony, Annette Evans, Rhian Daniel, Sara Long, Amrita Bandyopadhyay, Ann John, Mark A. Bellis and Shantini Paranjothy

    Citation: BMC Medicine 2021 19:172

    Content type: Research article

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  25. The high degree of heterogeneity brought great challenges to the diagnosis and treatment of acute myeloid leukemia (AML). Although several different AML prognostic scoring models have been proposed to assess t...

    Authors: Tiansheng Zeng, Longzhen Cui, Wenhui Huang, Yan Liu, Chaozeng Si, Tingting Qian, Cong Deng and Lin Fu

    Citation: BMC Medicine 2021 19:176

    Content type: Research article

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  26. The differential effect of pre-pregnancy low BMI on macrosomia has not been fully addressed. Herein, we conducted a city-wide population-based cohort study to illuminate the association between pre-pregnancy l...

    Authors: Guoju Li, Yuhan Xing, Guolan Wang, Jun Zhang, Qin Wu, Wei Ni, Na Jiao, Wenjing Chen, Qing Liu, Li Gao, Zhenhong Zhang, Yao Wang and Quansheng Xing

    Citation: BMC Medicine 2021 19:175

    Content type: Research article

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  27. The risk for several common cancers is influenced by the transcriptomic landscape of the respective tissue-of-origin. Vitamin D influences in vitro gene expression and cancer cell growth. We sought to determin...

    Authors: P. G. Vaughan-Shaw, G. Grimes, J. P. Blackmur, M. Timofeeva, M. Walker, L. Y. Ooi, Victoria Svinti, Kevin Donnelly, F. V. N. Din, S. M. Farrington and M. G. Dunlop

    Citation: BMC Medicine 2021 19:174

    Content type: Research article

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  28. Glucocorticoids could theoretically decrease breast cancer risk through their anti-inflammatory effects or increase risk through immunosuppression. However, epidemiological evidence is limited regarding the as...

    Authors: Manon Cairat, Marie Al Rahmoun, Marc J. Gunter, Pierre-Etienne Heudel, Gianluca Severi, Laure Dossus and Agnès Fournier

    Citation: BMC Medicine 2021 19:186

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2021 19:187

  29. Circulating vitamin C concentrations have been associated with several cancers in observational studies, but little is known about the causal direction of the associations. This study aims to explore the poten...

    Authors: Yuanqing Fu, Fengzhe Xu, Longda Jiang, Zelei Miao, Xinxiu Liang, Jian Yang, Susanna C. Larsson and Ju-Sheng Zheng

    Citation: BMC Medicine 2021 19:171

    Content type: Research article

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  30. All-cause mortality following atrial fibrillation (AF) has decreased over time. Data regarding temporal trends in causes of death among individuals with AF are scarce. The aim of our study was to analyze tempo...

    Authors: Jelena Kornej, Qiuxi Huang, Sarah R. Preis, Steven A. Lubitz, Darae Ko, Joanne M. Murabito, Emelia J. Benjamin and Ludovic Trinquart

    Citation: BMC Medicine 2021 19:170

    Content type: Research article

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  31. The rapid process of research and development and lack of follow-up time post-vaccination aroused great public concern about the safety profile of COVID-19 vaccine candidates. To provide comprehensive overview...

    Authors: Qianhui Wu, Matthew Z. Dudley, Xinghui Chen, Xufang Bai, Kaige Dong, Tingyu Zhuang, Daniel Salmon and Hongjie Yu

    Citation: BMC Medicine 2021 19:173

    Content type: Research article

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  32. In 2011, the World Health Organization recommended injectable artesunate as the first-line therapy for severe malaria (SM) due to its superiority in reducing mortality compared to quinine. There are limited da...

    Authors: Andrea L. Conroy, Robert O. Opoka, Paul Bangirana, Ruth Namazzi, Allen E. Okullo, Michael K. Georgieff, Sarah Cusick, Richard Idro, John M. Ssenkusu and Chandy C. John

    Citation: BMC Medicine 2021 19:168

    Content type: Research article

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  33. Light-to-moderate alcohol consumption has been reported to be cardio-protective among apparently healthy individuals; however, it is unclear whether this association is also present in those with disease. To e...

    Authors: Chengyi Ding, Dara O’Neill, Steven Bell, Emmanuel Stamatakis and Annie Britton

    Citation: BMC Medicine 2021 19:167

    Content type: Research article

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  34. The global pandemic of coronavirus disease 2019 (COVID-19) is caused by infection with the SARS-CoV-2 virus. Currently, there are three approved vaccines against SARS-CoV-2 in the USA, including two based on m...

    Authors: Elizabeth Fraley, Cas LeMaster, Eric Geanes, Dithi Banerjee, Santosh Khanal, Elin Grundberg, Rangaraj Selvarangan and Todd Bradley

    Citation: BMC Medicine 2021 19:169

    Content type: Research article

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  35. Multiple omics technologies are increasingly applied to detect early, subtle molecular responses to environmental stressors for future disease risk prevention. However, there is an urgent need for further eval...

    Authors: Marta Gallego-Paüls, Carles Hernández-Ferrer, Mariona Bustamante, Xavier Basagaña, Jose Barrera-Gómez, Chung-Ho E. Lau, Alexandros P. Siskos, Marta Vives-Usano, Carlos Ruiz-Arenas, John Wright, Remy Slama, Barbara Heude, Maribel Casas, Regina Grazuleviciene, Leda Chatzi, Eva Borràs…

    Citation: BMC Medicine 2021 19:166

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2021 19:210

  36. Immune checkpoint inhibitor (ICI) therapy elicits durable antitumor responses in patients with many types of cancer. Genomic mutations may be used to predict the clinical benefits of ICI therapy. NOTCH homolog...

    Authors: Junyu Long, Dongxu Wang, Xu Yang, Anqiang Wang, Yu Lin, Mingjun Zheng, Haohai Zhang, Xinting Sang, Hanping Wang, Ke Hu and Haitao Zhao

    Citation: BMC Medicine 2021 19:154

    Content type: Research article

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  37. Environmental factors are associated with human longevity, but their specificity and causality remain mostly unclear. By integrating the innovative “exposome” concept developed in the field of environmental ep...

    Authors: Shu-Yi Huang, Yu-Xiang Yang, Shi-Dong Chen, Hong-Qi Li, Xue-Qing Zhang, Kevin Kuo, Lan Tan, Lei Feng, Qiang Dong, Can Zhang and Jin-Tai Yu

    Citation: BMC Medicine 2021 19:150

    Content type: Research article

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  38. Randomized controlled trials have shown a higher sensitivity and longer negative predictive value of high-risk human papillomavirus (HPV) testing than cytology for cervical cancer screening; however, little is...

    Authors: Yanxia Zhao, Heling Bao, Lan Ma, Bo Song, Jiangli Di, Linhong Wang, Yanqiu Gao, Wenhui Ren, Shi Wang, Hai-Jun Wang and Jiuling Wu

    Citation: BMC Medicine 2021 19:164

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2021 19:165

  39. Few studies had described the health consequences of patients with coronavirus disease 2019 (COVID-19) especially in those with severe infections after discharge from hospital. Moreover, no research had report...

    Authors: Lijuan Xiong, Qian Li, Xiongjing Cao, Huangguo Xiong, Ming Huang, Fengwen Yang, Qingquan Liu, Daquan Meng, Mei Zhou, Gang Wang, Jun Tong, Tengfei Chen, Yanzhao Zhang, Xinliang He, Yunzhou Fan, Yupeng Zhang…

    Citation: BMC Medicine 2021 19:163

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2021 19:200

  40. Periodontitis is among the most common chronic diseases worldwide, and it is one of the main reasons for tooth loss. Comprehensive profiling of the metabolite content of the saliva can enable the identificatio...

    Authors: Leonie Andörfer, Birte Holtfreter, Stefan Weiss, Rutger Matthes, Vinay Pitchika, Carsten Oliver Schmidt, Stefanie Samietz, Gabi Kastenmüller, Matthias Nauck, Uwe Völker, Henry Völzke, Laszlo N. Csonka, Karsten Suhre, Maik Pietzner and Thomas Kocher

    Citation: BMC Medicine 2021 19:161

    Content type: Research article

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  41. When three SARS-CoV-2 vaccines came to market in Europe and North America in the winter of 2020–2021, distribution networks were in a race against a major epidemiological wave of SARS-CoV-2 that began in autum...

    Authors: Thu Nguyen-Anh Tran, Nathan B. Wikle, Emmy Albert, Haider Inam, Emily Strong, Karel Brinda, Scott M. Leighow, Fuhan Yang, Sajid Hossain, Justin R. Pritchard, Philip Chan, William P. Hanage, Ephraim M. Hanks and Maciej F. Boni

    Citation: BMC Medicine 2021 19:162

    Content type: Research article

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  42. Appropriate passive-active immunoprophylaxis effectively reduces mother-to-child transmission (MTCT) of hepatitis B virus (HBV), but the immunoprophylaxis failure was still more than 5% under the current strat...

    Authors: Xiaohui Zhang, Huaibin Zou, Yu Chen, Hua Zhang, Ruihua Tian, Jun Meng, Yunxia Zhu, Huimin Guo, Erhei Dai, Baoshen Zhu, Zhongsheng Liu, Yanxia Jin, Yujie Li, Liping Feng, Hui Zhuang, Calvin Q. Pan…

    Citation: BMC Medicine 2021 19:148

    Content type: Research article

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  43. East Africa is home to 170 million people and prone to frequent outbreaks of viral haemorrhagic fevers and various bacterial diseases. A major challenge is that epidemics mostly happen in remote areas, where i...

    Authors: Muna Affara, Hakim Idris Lagu, Emmanuel Achol, Richard Karamagi, Neema Omari, Grace Ochido, Eric Kezakarayagwa, Francine Kabatesi, Anatole Nkeshimana, Abdi Roba, Millicent Nyakio Ndia, Mamo U. Abudo, Alice Kabanda, Etienne Mpabuka, Emil Ivan Mwikarago, Philip Ezekiel Kutjok…

    Citation: BMC Medicine 2021 19:160

    Content type: Correspondence

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