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  1. Observational studies have revealed that type 2 diabetes (T2D) is associated with an increased risk of peripheral artery disease (PAD). However, whether the two diseases share a genetic basis and whether the r...

    Authors: Xuehao Xiu, Haoyang Zhang, Angli Xue, David N. Cooper, Li Yan, Yuedong Yang, Yuanhao Yang and Huiying Zhao
    Citation: BMC Medicine 2022 20:300
  2. Polycystic ovary syndrome (PCOS) affects up to one in five women of childbearing age. Observational studies assessing the association between maternal PCOS and adverse obstetric outcomes have reported varying ...

    Authors: Anuradhaa Subramanian, Siang Ing Lee, Katherine Phillips, Konstantinos A. Toulis, Punith Kempegowda, Michael W. O’Reilly, Nicola J. Adderley, Shakila Thangaratinam, Wiebke Arlt and Krishnarajah Nirantharakumar
    Citation: BMC Medicine 2022 20:298
  3. Frailty is a medical syndrome that is strongly associated with mortality risk and an emerging global health burden. Mental disorders are associated with reduced life expectancy and elevated levels of frailty. ...

    Authors: Julian Mutz, Umamah Choudhury, Jinlong Zhao and Alexandru Dregan
    Citation: BMC Medicine 2022 20:274
  4. Although targeted agents have been gradually applied in the treatment of HER2-mutated non-small cell lung cancer (NSCLC) in recent years, patients’ therapeutic demands are far from being met. PATHER2 was the firs...

    Authors: Guangjian Yang, Haiyan Xu, Yaning Yang, Shuyang Zhang, Fei Xu, Xuezhi Hao, Junling Li, Puyuan Xing, Xingsheng Hu, Yutao Liu, Lin Wang, Lin Lin, Zhijie Wang, Jianchun Duan, Jie Wang and Yan Wang
    Citation: BMC Medicine 2022 20:277
  5. Accurate diagnosis of unexplained cervical lymphadenopathy (CLA) using medical images heavily relies on the experience of radiologists, which is even worse for CLA patients in underdeveloped countries and regi...

    Authors: Yangyang Zhu, Zheling Meng, Xiao Fan, Yin Duan, Yingying Jia, Tiantian Dong, Yanfang Wang, Juan Song, Jie Tian, Kun Wang and Fang Nie
    Citation: BMC Medicine 2022 20:269
  6. RTS,S is the first malaria vaccine recommended for implementation among young children at risk. However, vaccine efficacy is modest and short-lived. Antibodies play the major role in vaccine-induced immunity, ...

    Authors: Gaoqian Feng, Liriye Kurtovic, Paul A. Agius, Elizabeth H. Aitken, Jahit Sacarlal, Bruce D. Wines, P. Mark Hogarth, Stephen J. Rogerson, Freya J. I. Fowkes, Carlota Dobaño and James G. Beeson
    Citation: BMC Medicine 2022 20:289
  7. There are no proven tumor biomarkers for the early diagnosis of clear cell renal cell carcinoma (ccRCC) thus far. This study aimed to identify novel biomarkers of ccRCC based on exosomal mRNA (emRNA) profiling...

    Authors: Xing He, Feng Tian, Fei Guo, Fangxing Zhang, Huiyong Zhang, Jin Ji, Lin Zhao, Jingyi He, Yutian Xiao, Longman Li, Chunmeng Wei, Caihong Huang, Yexin Li, Feng Zhang, Bo Yang, Huamao Ye…
    Citation: BMC Medicine 2022 20:270
  8. Non-medical issues (e.g. loneliness, financial concerns, housing problems) can shape how people feel physically and psychologically. This has been emphasised during the Covid-19 pandemic, especially for older ...

    Authors: Stephanie Tierney, Sebastien Libert, Jordan Gorenberg, Geoff Wong, Amadea Turk, Kerryn Husk, Helen J. Chatterjee, Kathryn Eccles, Caroline Potter, Emma Webster, Beth McDougall, Harriet Warburton, Lucy Shaw, Nia Roberts and Kamal R. Mahtani
    Citation: BMC Medicine 2022 20:260
  9. Gastrointestinal stromal tumor (GIST) is a rare type of cancer that occurs in the gastrointestinal tract. The majority of GIST cases carry oncogenic forms of KIT, the receptor for stem cell factor (SCF). Small...

    Authors: Dengyang Zhang, Chunxiao He, Yao Guo, Jianfeng Li, Bo Li, Yuming Zhao, Liuting Yu, Zhiguang Chang, Hanzhong Pei, Ming Yang, Na Li, Qi Zhang, Yulong He, Yihang Pan, Zhizhuang Joe Zhao, Changhua Zhang…
    Citation: BMC Medicine 2022 20:257
  10. Whether a genetic predisposition to psychiatric disorders is associated with coronavirus disease 2019 (COVID-19) is unknown.

    Authors: Wenwen Chen, Yu Zeng, Chen Suo, Huazhen Yang, Yilong Chen, Can Hou, Yao Hu, Zhiye Ying, Yajing Sun, Yuanyuan Qu, Donghao Lu, Fang Fang, Unnur A. Valdimarsdóttir and Huan Song
    Citation: BMC Medicine 2022 20:314
  11. Significant intertumoral heterogeneity exists as antitumor treatment is introduced. Heterogeneous therapeutic responses are conventionally evaluated by imaging examinations based on Response Evaluation Criteri...

    Authors: Jiawei Lv, Chenfei Wu, Junyan Li, Foping Chen, Shiwei He, Qingmei He, Guanqun Zhou, Jun Ma, Ying Sun, Denghui Wei and Li Lin
    Citation: BMC Medicine 2022 20:268
  12. The Sepsis-3 criteria introduced the system that uses the Sequential Organ-Failure Assessment (SOFA) score to define sepsis. The cardiovascular SOFA (CV SOFA) scoring system needs modification due to the chang...

    Authors: Hui Jai Lee, Byuk Sung Ko, Seung Mok Ryoo, Eunah Han, Gil Joon Suh, Sung-Hyuk Choi, Sung Phil Chung, Tae Ho Lim, Won Young Kim, Woon Yong Kwon, Sung Yeon Hwang, You Hwan Jo, Jonghwan Shin, Tae Gun Shin and Kyuseok Kim
    Citation: BMC Medicine 2022 20:263
  13. The relationship between non-alcoholic fatty liver degree as well as non-alcoholic fatty liver disease (NAFLD) and irritable bowel syndrome (IBS) remains poorly understood. We aimed to investigate the prospect...

    Authors: Shanshan Wu, Changzheng Yuan, Zhirong Yang, Si Liu, Qian Zhang, Shutian Zhang and Shengtao Zhu
    Citation: BMC Medicine 2022 20:262
  14. The Kin-Antwerp project aimed at improving the quality of care provided to patients with diabetes in Kinshasa, the Democratic Republic of the Congo in Central Africa, including the digitalisation of routine cl...

    Authors: Diana Sagastume, Elly Mertens, Deogratias Katsuva Sibongwere, Jean-Claude Dimbelolo, Jean Clovis Kalobu Kabundi, Jeroen de Man, Josefien Van Olmen and José L. Peñalvo
    Citation: BMC Medicine 2022 20:258
  15. Although the association between beverages and a single cardiometabolic disease has been well studied, their role in disease progression from the single cardiometabolic disease state to cardiometabolic multimo...

    Authors: Yi Luo, Lingfang He, Tianqi Ma, Jinchen Li, Yongping Bai, Xunjie Cheng and Guogang Zhang
    Citation: BMC Medicine 2022 20:273
  16. Periprostatic adipose tissue (PPAT) plays a role in prostate cancer (PCa) progression. PPAT lipidomic composition study may allow us to understand the tumor metabolic microenvironment and provide new stratific...

    Authors: Antonio Altuna-Coy, Xavier Ruiz-Plazas, Silvia Sánchez-Martin, Helena Ascaso-Til, Manuel Prados-Saavedra, Marta Alves-Santiago, Xana Bernal-Escoté, José Segarra-Tomás and Matilde R. Chacón
    Citation: BMC Medicine 2022 20:255
  17. Women experience adverse changes in cardiovascular health in mid-life; whether the menopausal transition influences these remains strongly debated. The aim of this study was to examine associations of reproduc...

    Authors: Gemma L. Clayton, Ana Gonçalves Soares, Fanny Kilpi, Abigail Fraser, Paul Welsh, Naveed Sattar, Scott M. Nelson, Kate Tilling and Deborah A. Lawlor
    Citation: BMC Medicine 2022 20:299
  18. Smoking is a major risk factor for cardiovascular disease and smoking cessation reduces excess risk. E-cigarettes are popular for smoking cessation but there is little evidence on their cardiovascular health e...

    Authors: Markos Klonizakis, Anil Gumber, Emma McIntosh and Leonie S. Brose
    Citation: BMC Medicine 2022 20:276
  19. During the COVID-19 pandemic, there have been concerns regarding potential bias in pulse oximetry measurements for people with high levels of skin pigmentation. We systematically reviewed the effects of skin p...

    Authors: Chunhu Shi, Mark Goodall, Jo Dumville, James Hill, Gill Norman, Oliver Hamer, Andrew Clegg, Caroline Leigh Watkins, George Georgiou, Alexander Hodkinson, Catherine Elizabeth Lightbody, Paul Dark and Nicky Cullum
    Citation: BMC Medicine 2022 20:267
  20. Plasma metabolomic profile is disturbed in dementia patients, but previous studies have discordant conclusions.

    Authors: Xinyu Zhang, Wenyi Hu, Yueye Wang, Wei Wang, Huan Liao, Xiayin Zhang, Katerina V. Kiburg, Xianwen Shang, Gabriella Bulloch, Yu Huang, Xueli Zhang, Shulin Tang, Yijun Hu, Honghua Yu, Xiaohong Yang, Mingguang He…
    Citation: BMC Medicine 2022 20:252
  21. Maternal smoking during pregnancy was reported to be associated with a reduced risk of type 1 diabetes in the offspring. We investigated whether this association is consistent with a causal interpretation by a...

    Authors: Yuxia Wei, Tomas Andersson, Jessica Edstorp, Josefin E. Löfvenborg, Mats Talbäck, Maria Feychting and Sofia Carlsson
    Citation: BMC Medicine 2022 20:240

    The Commentary to this article has been published in BMC Medicine 2022 20:296

  22. The risk of hip fracture in women on plant-based diets is unclear. We aimed to investigate the risk of hip fracture in occasional meat-eaters, pescatarians, and vegetarians compared to regular meat-eaters in t...

    Authors: James Webster, Darren C. Greenwood and Janet E. Cade
    Citation: BMC Medicine 2022 20:275
  23. Interleukin 6 (IL-6) signaling is being investigated as a therapeutic target for atherosclerotic cardiovascular disease (CVD). While changes in circulating high-sensitivity C-reactive protein (hsCRP) are used ...

    Authors: Marios K. Georgakis, Rainer Malik, Tom G. Richardson, Joanna M. M. Howson, Christopher D. Anderson, Stephen Burgess, G. Kees Hovingh, Martin Dichgans and Dipender Gill
    Citation: BMC Medicine 2022 20:245
  24. Adaptive designs are a class of methods for improving efficiency and patient benefit of clinical trials. Although their use has increased in recent years, research suggests they are not used in many situations...

    Authors: James M. S. Wason, Munyaradzi Dimairo, Katie Biggs, Sarah Bowden, Julia Brown, Laura Flight, Jamie Hall, Thomas Jaki, Rachel Lowe, Philip Pallmann, Mark A. Pilling, Claire Snowdon, Matthew R. Sydes, Sofía S. Villar, Christopher J. Weir, Nina Wilson…
    Citation: BMC Medicine 2022 20:254
  25. Although cholesterol metabolism is a common pathway for the development of antitumor drugs, there are no specific targets and drugs for clinical use. Here, based on our previous study of sterol O-acyltransfera...

    Authors: Zhihua Wang, Miaomiao Wang, Mengxin Zhang, Kaikun Xu, Xinshuai Zhang, Yi Xie, Yiming Zhang, Cheng Chang, Xiaolu Li, Aihua Sun and Fuchu He
    Citation: BMC Medicine 2022 20:292
  26. Both sleep quality and quantity are essential for normal brain development throughout childhood; however, the association between preterm birth and sleep problems in preschoolers is not yet clear, and the effe...

    Authors: Jiajun Lyu, John A. Groeger, Anna L. Barnett, Haifeng Li, Lei Wang, Jiajia Zhang, Wenchong Du and Jing Hua
    Citation: BMC Medicine 2022 20:253
  27. Prostate cancer is an epidemic of the modern age, and despite efforts to improve awareness, it remains the case that mortality has hardly altered over the decades, driven largely by late presentation. There is...

    Authors: Vincent J. Gnanapragasam, David Greenberg and Neil Burnet
    Citation: BMC Medicine 2022 20:264
  28. Early detection of breast cancer (BC) through mammography screening (MAM) is known to reduce mortality. We examined the differential effect that mammography has on BC characteristics and overall survival and t...

    Authors: Zi Lin Lim, Peh Joo Ho, Alexis Jiaying Khng, Yen Shing Yeoh, Amanda Tse Woon Ong, Benita Kiat Tee Tan, Ern Yu Tan, Su-Ming Tan, Geok Hoon Lim, Jung Ah Lee, Veronique Kiak-Mien Tan, Jesse Hu, Jingmei Li and Mikael Hartman
    Citation: BMC Medicine 2022 20:239
  29. Chronic kidney disease (CKD) in people with diabetes is becoming an increasing major public health concern, disproportionately burdening low- and middle-income countries (LMICs). This rising burden is due to v...

    Authors: Cindy George, Justin B. Echouffo-Tcheugui, Bernard G. Jaar, Ikechi G. Okpechi and Andre P. Kengne
    Citation: BMC Medicine 2022 20:247
  30. Although sexually transmitted infections are regarded as the main cause of tubal infertility, the association between the common vaginal microbiome and female fecundability has yet to be determined. The object...

    Authors: Xiang Hong, Jun Zhao, Jiechen Yin, Fanqi Zhao, Wei Wang, Xiaoling Ding, Hong Yu, Xu Ma and Bei Wang
    Citation: BMC Medicine 2022 20:246
  31. Authors: Bożena Wielgoszewska, Jane Maddock, Michael J. Green, Giorgio Di Gessa, Sam Parsons, Gareth J. Griffith, Jazz Croft, Anna J. Stevenson, Charlotte Booth, Richard J. Silverwood, David Bann, Praveetha Patalay, Alun D. Hughes, Nishi Chaturvedi, Laura D. Howe, Emla Fitzsimons…
    Citation: BMC Medicine 2022 20:285

    The original article was published in BMC Medicine 2022 20:147

  32. The combination of immune checkpoint inhibitors (ICIs) and chemotherapy has been the standard first-line treatment for advanced non-small cell lung cancer (NSCLC) patients with driver-gene negative. However, e...

    Authors: Juan Zhou, Minwei Bao, Guanghui Gao, Yiran Cai, Lihong Wu, Lei Lei, Jing Zhao, Xianxiu Ji, Ying Huang and Chunxia Su
    Citation: BMC Medicine 2022 20:256
  33. Behavioral weight loss interventions are frequently hampered by long-term inefficacy. As metabolic improvements and health-related quality of life (HRQoL) are diminished by weight regain, effective long-term s...

    Authors: Linna Li, Dominik Soll, Verena Leupelt, Joachim Spranger and Knut Mai
    Citation: BMC Medicine 2022 20:238
  34. Neonatal sepsis can induce long-term cognitive impairment in adolescence or adulthood, but the underlying molecular mechanism is not fully understood. The expression of K+-Cl co-transporter 2 (KCC2) plays a pivo...

    Authors: Donghang Zhang, Yujiao Yang, Yaoxin Yang, Jin Liu, Tao Zhu, Han Huang and Cheng Zhou
    Citation: BMC Medicine 2022 20:235
  35. Prescription medications such as selective serotonin reuptake inhibitors (SSRIs), commonly used to treat depression, are associated with weight gain. The role of pharmacogenomics in predicting SSRI-induced wei...

    Authors: Maria L. Ricardo-Silgado, Sneha Singh, Lizeth Cifuentes, Paul A. Decker, Daniel Gonzalez-Izundegui, Ann M. Moyer, Maria D. Hurtado, Michael Camilleri, Suzette J. Bielinski and Andres Acosta
    Citation: BMC Medicine 2022 20:261
  36. Lipids play a vital role in health and disease, but changes to their circulating levels and the link with obesity remain poorly characterized in expecting mothers and their offspring in early childhood.

    Authors: Sartaj Ahmad Mir, Li Chen, Satvika Burugupalli, Bo Burla, Shanshan Ji, Adam Alexander T. Smith, Kothandaraman Narasimhan, Adaikalavan Ramasamy, Karen Mei-Ling Tan, Kevin Huynh, Corey Giles, Ding Mei, Gerard Wong, Fabian Yap, Kok Hian Tan, Fiona Collier…
    Citation: BMC Medicine 2022 20:242
  37. Intraductal carcinoma of the prostate (IDC-P) is a subtype of prostate cancer featured by poor prognosis. Previous studies suggested IDC-P could have a potentially unstable genome. Homologous recombination def...

    Authors: Sha Zhu, Jinge Zhao, Ling Nie, Wenlian Yin, Yaowen Zhang, Fengnian Zhao, Yuchao Ni, Xingming Zhang, Zhipeng Wang, Jindong Dai, Zhenhua Liu, Junru Chen, Yuhao Zeng, Zilin Wang, Guangxi Sun, Jiayu Liang…
    Citation: BMC Medicine 2022 20:237
  38. The protective effect of T cell-mediated immunity against influenza virus infections in natural settings remains unclear, especially in seasonal epidemics.

    Authors: Tim K. Tsang, Kwok-Tai Lam, Yinping Liu, Vicky J. Fang, Xiaofeng Mu, Nancy H. L. Leung, J. S. Malik Peiris, Gabriel M. Leung, Benjamin J. Cowling and Wenwei Tu
    Citation: BMC Medicine 2022 20:230
  39. Acute kidney injury (AKI) is common and associated with adverse outcomes as well as important healthcare costs. However, evidence examining the epidemiology of acute kidney disease (AKD)—recently defined as AK...

    Authors: Huan Wang, Emilie Lambourg, Bruce Guthrie, Daniel R. Morales, Peter T. Donnan and Samira Bell
    Citation: BMC Medicine 2022 20:229
  40. Multimorbidity is a rising global phenomenon, placing strains on countries’ population health and finances. This systematic review provides insight into the costs of multimorbidity through addressing the follo...

    Authors: Phuong Bich Tran, Joseph Kazibwe, Georgios F. Nikolaidis, Ismo Linnosmaa, Mieke Rijken and Josefien van Olmen
    Citation: BMC Medicine 2022 20:234
  41. At present, the extent and clinical relevance of epigenetic differences between upper tract urothelial carcinoma (UTUC) and urothelial carcinoma of the bladder (UCB) remain largely unknown. Here, we conducted ...

    Authors: Juan Li, Yuan Liang, Jian Fan, Chunru Xu, Bao Guan, Jianye Zhang, Bin Guo, Yue Shi, Ping Wang, Yezhen Tan, Qi Zhang, Changwei Yuan, Yucai Wu, Liqun Zhou, Weimin Ci and Xuesong Li
    Citation: BMC Medicine 2022 20:222
  42. Family history (FamH) of type 2 diabetes might indicate shared genotypes, environments, and/or behaviors. We hypothesize that FamH interacts with unhealthy behaviors to increase the risk of early onset of diab...

    Authors: Johnny T. K. Cheung, Eric Lau, Cyrus C. T. Tsui, Edmond L. N. Siu, Naomi K. W. Tse, Nicole Y. L. Hui, Ronald C. W. Ma, Alice P. S. Kong, Amy Fu, Vanessa Lau, Weiping Jia, Wayne H. H. Sheu, Leorino Sobrepena, K. H. Yoon, Alexander T. B. Tan, Yook-Chin Chia…
    Citation: BMC Medicine 2022 20:249