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  1. Melanoma incidence is on the rise and advanced melanoma carries an extremely poor prognosis. Treatment options, including chemotherapy and immunotherapy, are limited and offer low response rates and transient ...

    Authors: Yixiang Wang, Soroosh Radfar, Suhu Liu, Adam I Riker and Hung T Khong
    Citation: BMC Medicine 2010 8:14
    Content type: Research article Published on:

  2. There are currently no accurate serum markers for detecting early risk of colorectal cancer (CRC). We therefore developed a non-targeted metabolomics technology to analyse the serum of pre-treatment CRC patien...

    Authors: Shawn A Ritchie, Pearson WK Ahiahonu, Dushmanthi Jayasinghe, Doug Heath, Jun Liu, Yingshen Lu, Wei Jin, Amir Kavianpour, Yasuyo Yamazaki, Amin M Khan, Mohammad Hossain, Khine Khine Su-Myat, Paul L Wood, Kevin Krenitsky, Ichiro Takemasa, Masakazu Miyake…
    Citation: BMC Medicine 2010 8:13
    Content type: Research article Published on:

  3. DNA-methyltransferase (DNMT)-3A plays an important role in the development of embryogenesis and the generation of aberrant methylation in carcinogenesis. The aim of this study was to investigate the role of a ...

    Authors: Hong Fan, Dongsheng Liu, Xuemei Qiu, Fengchang Qiao, Qingxiang Wu, Xianwei Su, Feng Zhang, Yunwei Song, Zhujiang Zhao and Wei Xie
    Citation: BMC Medicine 2010 8:12
    Content type: Research article Published on:

  4. Although poorly described in the literature, the practice of early (short-interval) rescreen after a negative screening mammogram is controversial due to its financial and psychological burden and because it i...

    Authors: Alessandra Ravaioli, Flavia Foca, Americo Colamartini, Fabio Falcini, Carlo Naldoni, Alba C Finarelli, Priscilla Sassoli de Bianchi and Lauro Bucchi
    Citation: BMC Medicine 2010 8:11
    Content type: Research article Published on:

  5. Low back pain is a highly prevalent and disabling condition worldwide. Clinical guidelines for the management of patients with acute low back pain recommend first-line treatment consisting of advice, reassuran...

    Authors: Luciana AC Machado, Chris G Maher, Rob D Herbert, Helen Clare and James H McAuley
    Citation: BMC Medicine 2010 8:10
    Content type: Research article Published on:

  6. Chest pain raises concern for the possibility of coronary heart disease. Scoring methods have been developed to identify coronary heart disease in emergency settings, but not in primary care.

    Authors: Baris Gencer, Paul Vaucher, Lilli Herzig, François Verdon, Christiane Ruffieux, Stefan Bösner, Bernard Burnand, Thomas Bischoff, Norbert Donner-Banzhoff and Bernard Favrat
    Citation: BMC Medicine 2010 8:9
    Content type: Research article Published on:

  7. Almost five decades ago, governments around the world adopted the 1961 Single Convention on Narcotic Drugs which, in addition to addressing the control of illicit narcotics, obligated countries to work towards...

    Authors: Diederik Lohman, Rebecca Schleifer and Joseph J Amon
    Citation: BMC Medicine 2010 8:8
    Content type: Debate Published on:

  8. Diagnosis-based risk adjustment is becoming an important issue globally as a result of its implications for payment, high-risk predictive modelling and provider performance assessment. The Taiwanese National H...

    Authors: Hsien-Yen Chang and Jonathan P Weiner
    Citation: BMC Medicine 2010 8:7
    Content type: Research article Published on:

  10. Inflammatory cytokines play a crucial role in coronary artery disease (CAD). We investigated the association between 48 coding and three non-coding single nucleotide polymorphisms (SNPs) from 35 inflammatory g...

    Authors: Benjamin D Brown, Jérémie Nsengimana, Jennifer H Barrett, Richard A Lawrence, Lori Steiner, Suzanne Cheng, D Timothy Bishop, Nilesh J Samani, Stephen G Ball, Anthony J Balmforth and Alistair S Hall
    Citation: BMC Medicine 2010 8:5
    Content type: Research article Published on:

  11. The U.S. Food and Drug Administration (FDA) recently linked antiepileptic drug (AED) exposure to suicide-related behaviors based on meta-analysis of randomized clinical trials. We examined the relationship bet...

    Authors: Anne C VanCott, Joyce A Cramer, Laurel A Copeland, John E Zeber, Michael A Steinman, Jeffrey J Dersh, Mark E Glickman, Eric M Mortensen, Megan E Amuan and Mary Jo Pugh
    Citation: BMC Medicine 2010 8:4
    Content type: Research article Published on:

  12. Platinum-based combinations are the standard second-line treatment for platinum-sensitive ovarian cancer (OC). This randomized phase II study was undertaken in order to compare the combination of carboplatin a...

    Authors: Dimitrios Bafaloukos, Helena Linardou, Gerasimos Aravantinos, Christos Papadimitriou, Aristotelis Bamias, George Fountzilas, Haralabos P Kalofonos, Paris Kosmidis, Eleni Timotheadou, Thomas Makatsoris, Epaminondas Samantas, Evangelos Briasoulis, Christos Christodoulou, Pavlos Papakostas, Dimitrios Pectasides and Athanasios M Dimopoulos
    Citation: BMC Medicine 2010 8:3
    Content type: Research article Published on:

  14. Insulin-like growth factor-1 (IGF-I) signalling is important for cancer initiation and progression. Given the emerging evidence for the role of the stroma in these processes, we aimed to characterize the effec...

    Authors: Michal Rajski, Rosanna Zanetti-Dällenbach, Brigitte Vogel, Richard Herrmann, Christoph Rochlitz and Martin Buess
    Citation: BMC Medicine 2010 8:1
    Content type: Research article Published on:

  16. Directly observed therapy (DOT) remains the cornerstone of the global tuberculosis (TB) control strategy. Tanzania, one of the 22 high-burden countries regarding TB, changed the first-line treatment regimen to...

    Authors: Saidi Egwaga, Abdallah Mkopi, Nyagosya Range, Vera Haag-Arbenz, Amuri Baraka, Penny Grewal, Frank Cobelens, Hassan Mshinda, Fred Lwilla and Frank van Leth
    Citation: BMC Medicine 2009 7:80
    Content type: Research article Published on:

  18. It is becoming increasingly apparent that cancer drug therapies can only reach their full potential through appropriate patient selection. Matching drugs and cancer patients has proven to be a complex challeng...

    Authors: Cyril Benes and Jeff Settleman
    Citation: BMC Medicine 2009 7:78
    Content type: Commentary Published on:

  19. Polyamines regulate important cellular functions and polyamine dysregulation frequently occurs in cancer. The objective of this study was to use a systems approach to study the relative effects of PG-11047, a ...

    Authors: Wen-Lin Kuo, Debopriya Das, Safiyyah Ziyad, Sanchita Bhattacharya, William J Gibb, Laura M Heiser, Anguraj Sadanandam, Gerald V Fontenay, Zhi Hu, Nicholas J Wang, Nora Bayani, Heidi S Feiler, Richard M Neve, Andrew J Wyrobek, Paul T Spellman, Laurence J Marton…
    Citation: BMC Medicine 2009 7:77
    Content type: Research article Published on:

  21. Intervention coverage and funding for the control of malaria in Africa has increased in recent years, however, there are few descriptions of changing disease burden and the few reports available are from isola...

    Authors: Emelda A Okiro, Victor A Alegana, Abdisalan M Noor, Juliette J Mutheu, Elizabeth Juma and Robert W Snow
    Citation: BMC Medicine 2009 7:75
    Content type: Research article Published on:

  22. Multiple sclerosis, the most common neurologic disorder of young adults, is traditionally considered to be an inflammatory, autoimmune, demyelinating disease of the central nervous system. Based on this unders...

    Authors: Rebecca I Spain, Michelle H Cameron and Dennis Bourdette
    Citation: BMC Medicine 2009 7:74
    Content type: Minireview Published on:

  23. With the rise of the second pandemic wave of the novel influenza A (H1N1) virus in the current season in the Northern Hemisphere, pandemic plans are being carefully re-evaluated, particularly for the strategic...

    Authors: Seyed M Moghadas, Christopher S Bowman, Gergely Röst, David N Fisman and Jianhong Wu
    Citation: BMC Medicine 2009 7:73
    Content type: Research article Published on:

  26. High dose oral ascorbic acid substantially improved myelination and locomotor function in a Charcot-Marie-Tooth type 1A mouse model. A phase II study was warranted to investigate whether high dose ascorbic aci...

    Authors: Camiel Verhamme, Rob J de Haan, Marinus Vermeulen, Frank Baas, Marianne de Visser and Ivo N van Schaik
    Citation: BMC Medicine 2009 7:70
    Content type: Research article Published on:

  27. Recently published results from a large randomized trial (Canadian Cervical Cancer Screening Trial study group) suggest that human papillomavirus testing followed by Pap smear-based triage for human papillomav...

    Authors: Shalini L Kulasingam, Raghu Rajan, Yvan St Pierre, C Victoria Atwood, Evan R Myers and Eduardo L Franco
    Citation: BMC Medicine 2009 7:69
    Content type: Research article Published on:

  28. The Signal Transducer and Activator of Transcription 1 (STAT1) has traditionally been regarded as a transmitter of interferon signaling and a pro-apoptotic tumour suppressor. Recent data have identified new fu...

    Authors: Sean P Pitroda, Bassam T Wakim, Ravi F Sood, Mara G Beveridge, Michael A Beckett, Dhara M MacDermed, Ralph R Weichselbaum and Nikolai N Khodarev
    Citation: BMC Medicine 2009 7:68
    Content type: Research article Published on:

  29. Tuberculosis contributes significantly to morbidity and mortality among HIV-infected children in sub-Saharan Africa. Isoniazid prophylaxis can reduce tuberculosis incidence in this population. However, for the...

    Authors: Stanzi M le Roux, Mark F Cotton, Jonathan E Golub, David M le Roux, Lesley Workman and Heather J Zar
    Citation: BMC Medicine 2009 7:67
    Content type: Research article Published on:

  30. Alzheimer's disease is the most common progressive neurodegenerative disease. In recent years, numerous progresses in the discovery of novel Alzheimer's disease molecular biomarkers in brain as well as in biol...

    Authors: Alessandra Pani, Antonella Mandas, Giacomo Diaz, Claudia Abete, Pier Luigi Cocco, Fabrizio Angius, Annalisa Brundu, Nico Muçaka, Maria Elena Pais, Antonio Saba, Luigi Barberini, Cristina Zaru, Manuela Palmas, Paolo F Putzu, Alessandra Mocali, Francesco Paoletti…
    Citation: BMC Medicine 2009 7:66
    Content type: Research article Published on:

  31. The decreasing range of joint motion caused by insufficient muscle length is a common problem in children with cerebral palsy (CP), often worsening with age. In 1994 a CP register and health care programme for...

    Authors: Eva Nordmark, Gunnar Hägglund, Henrik Lauge-Pedersen, Philippe Wagner and Lena Westbom
    Citation: BMC Medicine 2009 7:65
    Content type: Research article Published on:

  34. Autism comprises a spectrum of behavioral and cognitive disturbances of childhood development and is known to be highly heritable. Although numerous approaches have been used to identify genes implicated in th...

    Authors: Simon G Gregory, Jessica J Connelly, Aaron J Towers, Jessica Johnson, Dhani Biscocho, Christina A Markunas, Carla Lintas, Ruth K Abramson, Harry H Wright, Peter Ellis, Cordelia F Langford, Gordon Worley, G Robert Delong, Susan K Murphy, Michael L Cuccaro, Antonello Persico…
    Citation: BMC Medicine 2009 7:62
    Content type: Research article Published on:

  36. Suicidal thoughts and behaviours during antidepressant treatment, especially during the first weeks of treatment, have prompted warnings by regulatory bodies. The aim of the present study is to investigate the...

    Authors: Nader Perroud, Rudolf Uher, Andrej Marusic, Marcella Rietschel, Ole Mors, Neven Henigsberg, Joanna Hauser, Wolfgang Maier, Daniel Souery, Anna Placentino, Aleksandra Szczepankiewicz, Lisbeth Jorgensen, Jana Strohmaier, Astrid Zobel, Caterina Giovannini, Amanda Elkin…
    Citation: BMC Medicine 2009 7:60
    Content type: Research article Published on:

  37. An understanding of how public health research output from India is changing in relation to the disease burden and public health priorities is required in order to inform relevant research development. We ther...

    Authors: Lalit Dandona, Magdalena Z Raban, Rama K Guggilla, Aarushi Bhatnagar and Rakhi Dandona
    Citation: BMC Medicine 2009 7:59
    Content type: Correspondence Published on:

  39. The diagnosis of chronic fatigue syndrome (CFS) in research studies requires the exclusion of subjects with medical and psychiatric conditions that could confound the analysis and interpretation of results. Th...

    Authors: James F Jones, Jin-Mann S Lin, Elizabeth M Maloney, Roumiana S Boneva, Urs M Nater, Elizabeth R Unger and William C Reeves
    Citation: BMC Medicine 2009 7:57
    Content type: Research article Published on:

  40. There is increasing concern among many in the medical arena about the extent to which the effects of treatment, either good or bad, apply to specific subgroups of individuals. Women comprise one of the most fr...

    Authors: Jesse A Berlin and Susan S Ellenberg
    Citation: BMC Medicine 2009 7:56
    Content type: Commentary Published on:

  41. In June 2009, BMC Medicine received its first official impact factor of 3.28 from Thomson Reuters. In recognition of this landmark event, the BMC Medicine editorial team present and discuss the vision and aims of...

    Authors: Robin L Cassady-Cain, Joanne M Appleford, Jigisha Patel, Mick Aulakh and Melissa L Norton
    Citation: BMC Medicine 2009 7:55
    Content type: Editorial Published on:

  42. Bangladesh, India and Nepal are working towards the elimination of visceral leishmaniasis (VL) by 2015. In 2005 the World Health Organization/Training in Tropical Diseases launched an implementation research p...

    Authors: Anand B Joshi, Murari L Das, Shireen Akhter, Rajib Chowdhury, Dinesh Mondal, Vijay Kumar, Pradeep Das, Axel Kroeger, Marleen Boelaert and Max Petzold
    Citation: BMC Medicine 2009 7:54
    Content type: Research article Published on:

  43. A growing body of evidence suggests that psychological stress contributes to coronary artery disease. However, associations between stress and stroke are less clear. In this study, we investigated the possible...

    Authors: Katarina Jood, Petra Redfors, Annika Rosengren, Christian Blomstrand and Christina Jern
    Citation: BMC Medicine 2009 7:53
    Content type: Research article Published on:

  44. The 1996 Australian National Firearms Agreement introduced strict access limitations. However, reports on the effectiveness of the new legislation are conflicting. This study, accessing all cases of suicide 19...

    Authors: Helen Klieve, Jerneja Sveticic and Diego De Leo
    Citation: BMC Medicine 2009 7:52
    Content type: Research article Published on:

  45. Currently, treatments for ischemic stroke focus on restoring or improving perfusion to the ischemic area using thrombolytics. The increased hospitalization costs related to thrombolysis are offset by a decreas...

    Authors: Julien Bogousslavsky and Maurizio Paciaroni
    Citation: BMC Medicine 2009 7:51
    Content type: Commentary Published on:

  46. The UK, USA and the World Health Organization have identified improved patient safety in healthcare as a priority. Medication error has been identified as one of the most frequent forms of medical error and is...

    Authors: Sara Garfield, Nick Barber, Paul Walley, Alan Willson and Lina Eliasson
    Citation: BMC Medicine 2009 7:50
    Content type: Research article Published on:

  47. Schools are the most frequent target for intervention programs aimed at preventing child obesity; however, the overall effectiveness of these programs has been limited. It has therefore been recommended that i...

    Authors: Douglas A Gentile, Greg Welk, Joey C Eisenmann, Rachel A Reimer, David A Walsh, Daniel W Russell, Randi Callahan, Monica Walsh, Sarah Strickland and Katie Fritz
    Citation: BMC Medicine 2009 7:49
    Content type: Research article Published on:

  49. African children have some of the highest rates of bacterial meningitis in the world. Bacterial meningitis in Africa is associated with high case fatality and frequent neuropsychological sequelae. The objectiv...

    Authors: Meenakshi Ramakrishnan, Aaron J Ulland, Laura C Steinhardt, Jennifer C Moïsi, Fred Were and Orin S Levine
    Citation: BMC Medicine 2009 7:47
    Content type: Research article Published on:
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