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  1. Obesity is a well-defined risk factor for heart failure with preserved ejection fraction (HFpEF), but it is associated with a better prognosis in patients with diagnosed HFpEF. The paradoxically poor prognosis...

    Authors: Bin Dong, Yiling Yao, Ruicong Xue, Weihao Liang, Jiangui He, Fangfei Wei, Yugang Dong, Xin He and Chen Liu
    Citation: BMC Medicine 2022 20:423
  2. Currently, there is limited evidence about the long-term impact on physical, social and emotional functioning, i.e. health-related quality of life (HRQL) after mild or moderate COVID-19 not requiring hospitali...

    Authors: Anouk Verveen, Elke Wynberg, Hugo D. G. van Willigen, Udi Davidovich, Anja Lok, Eric P. Moll van Charante, Menno D. de Jong, Godelieve de Bree, Maria Prins, Hans Knoop and Pythia T. Nieuwkerk
    Citation: BMC Medicine 2022 20:422
  3. Prophylactic antibiotic use during delivery is common in routine obstetric practice to prevent infection globally, especially in low- and middle-income countries. In China, however, little is currently known a...

    Authors: Qiguo Lian, Tao Zheng, Xiaona Huo, Jun Zhang and Lin Zhang
    Citation: BMC Medicine 2022 20:391
  4. Psoriasis has been linked to cardiovascular disease (CVD), including coronary artery disease (CAD), myocardial infarction (MI), and heart failure (HF). However, available studies regarding this relationship ha...

    Authors: Liming Zhang, Yuxiang Wang, Li Qiu and Jian Wu
    Citation: BMC Medicine 2022 20:421
  5. Multimorbidity (the presence of two or more chronic conditions) is common amongst people with chronic kidney disease, but it is unclear which conditions cluster together and if this changes as kidney function ...

    Authors: Michael K. Sullivan, Juan-Jesus Carrero, Bhautesh Dinesh Jani, Craig Anderson, Alex McConnachie, Peter Hanlon, Dorothea Nitsch, David A. McAllister, Frances S. Mair, Patrick B. Mark and Alessandro Gasparini
    Citation: BMC Medicine 2022 20:420
  6. Observational epidemiological studies suggest a link between several factors related to ovulation and reproductive function and endometrial cancer (EC) risk; however, it is not clear whether these relationship...

    Authors: Shannon D’Urso, Pooja Arumugam, Therese Weider, Liang-Dar Hwang, Tom A. Bond, John P. Kemp, Nicole M. Warrington, David M. Evans, Tracy A. O’Mara and Gunn-Helen Moen
    Citation: BMC Medicine 2022 20:419
  7. Multiple human pathogens establish chronic, sometimes life-long infections. Even if they are often latent, these infections can trigger some degree of local or systemic immune response, resulting in chronic lo...

    Authors: Flavia Hodel, Olivier Naret, Clara Bonnet, Nicole Brenner, Noemi Bender, Tim Waterboer, Pedro Marques-Vidal, Peter Vollenweider and Jacques Fellay
    Citation: BMC Medicine 2022 20:416
  8. Breastmilk is a dynamic fluid whose initial function is to provide the most adapted nutrition to the neonate. Additional attributes have been recently ascribed to breastmilk, with the evidence of a specific mi...

    Authors: Raúl Piñeiro-Salvador, Eduardo Vazquez-Garza, José Antonio Cruz-Cardenas, Cuauhtémoc Licona-Cassani, Gerardo García-Rivas, Jorge Moreno-Vásquez, Mario René Alcorta-García, Victor Javier Lara-Diaz and Marion E. G. Brunck
    Citation: BMC Medicine 2022 20:388
  9. The World Health Organization (WHO) has developed a costing tool, the Cervical Cancer Prevention and Control Costing (C4P) tool, to estimate the comprehensive cost of cervical cancer primary, secondary and ter...

    Authors: Ann Levin, Safina Yuma, Edwin Swai, Winthrop Morgan, Cindy L. Gauvreau, Nathalie Broutet, Karene Hoi Ting Yeung and Raymond Hutubessy
    Citation: BMC Medicine 2022 20:384
  10. Hepatic arterial infusion chemotherapy (HAIC) with oxaliplatin and 5-fluorouracil was effective in unresectable hepatocellular carcinoma (HCC). The program of FOLFOX-HAIC in HCC was performed for 1 day (HAIC 1...

    Authors: Zhicheng Lai, Yexing Huang, Dongsheng Wen, Xuanjia Lin, Anna Kan, Qijiong Li, Wei Wei, Minshan Chen, Li Xu, Minke He and Ming Shi
    Citation: BMC Medicine 2022 20:415
  11. The combination of oncolytic viruses (OVs) with immune checkpoint blockades is a research hotspot and has shown good efficacy. Here, we present the first attempt to combine oncolytic herpes simplex virus 2 (OH...

    Authors: Defeng Kong, Zhenrong Yang, Guoliang Li, Quanyou Wu, Zhaoru Gu, Duo Wan, Qi Zhang, Xiaoli Zhang, Shujun Cheng, Binlei Liu, Kaitai Zhang and Wen Zhang
    Citation: BMC Medicine 2022 20:376
  12. Though the association between air pollution and incident type 2 diabetes (T2D) has been well documented, evidence on the association with development of subsequent diabetes complications and post-diabetes mor...

    Authors: Yinglin Wu, Shiyu Zhang, Samantha E. Qian, Miao Cai, Haitao Li, Chongjian Wang, Hongtao Zou, Lan Chen, Michael G. Vaughn, Stephen Edward McMillin and Hualiang Lin
    Citation: BMC Medicine 2022 20:375
  13. Circulating levels of amino acids were associated with blood pressure (BP) in observational studies. However, the causation of such associations has been hypothesized but is difficult to prove in human studies...

    Authors: Chenhao Lin, Zhonghan Sun, Zhendong Mei, Hailuan Zeng, Manying Zhao, Jianying Hu, Mingfeng Xia, Tao Huang, Chaolong Wang, Xin Gao and Yan Zheng
    Citation: BMC Medicine 2022 20:414
  14. Heavy drinking was well associated with an increased risk of hepatocellular carcinoma (HCC), whereas the effect of low-to-moderate drinking on HCC remains under debate.

    Authors: Zhenqiu Liu, Ci Song, Chen Suo, Hong Fan, Tiejun Zhang, Li Jin and Xingdong Chen
    Citation: BMC Medicine 2022 20:413
  15. Parkinson’s disease (PD) is the second most common neurodegenerative disease in middle-aged and elderly populations, whereas there is no cure for PD so far. Novel animal models and medications await developmen...

    Authors: Jiangbo Song, Lian Liu, Zhiquan Li, Ting Mao, Jianfei Zhang, Lei Zhou, Xin Chen, Yunzhu Shang, Tao Sun, Yuxin Luo, Yu Jiang, Duan Tan, Xiaoling Tong and Fangyin Dai
    Citation: BMC Medicine 2022 20:412
  16. The application of combination therapy for cancer treatment is limited due to poor tumor-specific drug delivery and the abscopal effect.

    Authors: Yibin Cheng, Caixia Wang, Huihui Wang, Zhiwei Zhang, Xiaopeng Yang, Yanming Dong, Lixin Ma and Jingwen Luo
    Citation: BMC Medicine 2022 20:411
  17. The applicability of randomised controlled trials of pharmacological agents to older people with frailty/multimorbidity is often uncertain, due to concerns that trials are not representative. However, assessin...

    Authors: Peter Hanlon, Elaine Butterly, Anoop S. V. Shah, Laurie J. Hannigan, Sarah H. Wild, Bruce Guthrie, Frances S. Mair, Sofia Dias, Nicky J. Welton and David A. McAllister
    Citation: BMC Medicine 2022 20:410
  18. Pragmatic trials aim to generate evidence to directly inform patient, caregiver and health-system manager policies and decisions. Heterogeneity in patient characteristics contributes to heterogeneity in their ...

    Authors: Bruno Giraudeau, Agnès Caille, Sandra M. Eldridge, Charles Weijer, Merrick Zwarenstein and Monica Taljaard
    Citation: BMC Medicine 2022 20:372
  19. Type 2 diabetes mellitus (T2DM) is one of the most widely spread diseases, affecting around 90% of the patients with diabetes. Metabolomics has proven useful in diabetes research discovering new biomarkers to ...

    Authors: Marina Mora-Ortiz, Juan F. Alcala-Diaz, Oriol Alberto Rangel-Zuñiga, Antonio Pablo Arenas-de Larriva, Fernando Abollo-Jimenez, Diego Luque-Cordoba, Feliciano Priego-Capote, Maria M. Malagon, Javier Delgado-Lista, Jose M. Ordovas, Pablo Perez-Martinez, Antonio Camargo and Jose Lopez-Miranda
    Citation: BMC Medicine 2022 20:373
  20. Although guidelines recommend lipid injectable emulsions (ILEs) be used as a part of parenteral nutrition, many patients in Japan receive lipid-free parenteral nutrition. Furthermore, little is known about the...

    Authors: Kosei Takagi, Kenta Murotani, Satoru Kamoshita and Akiyoshi Kuroda
    Citation: BMC Medicine 2022 20:371
  21. Observational studies support a role for oral anticoagulation to reduce the risk of dementia in atrial fibrillation patients, but conclusive data are lacking. Since dabigatran offers a more stable anticoagulat...

    Authors: Bruno Caramelli, Pai Ching Yu, Francisco A. M. Cardozo, Iuri R. Magalhães, Raphael R. Spera, Daniel K. Amado, Maria C. Escalante-Rojas, Danielle M. Gualandro, Daniela Calderaro, Caio A. M. Tavares, Flavio A. Borges-Junior, Adriana F. Pastana, Mariana G. Matheus, Sonia M. D. Brucki, Ana Carolina O. Rodrigues, Ricardo Nitrini…
    Citation: BMC Medicine 2022 20:374
  22. Chronic kidney disease patients are at increased risk of mortality with cardiovascular diseases and infections as the two leading causes of death for end-stage kidney disease treated with hemodialysis (HD). Mo...

    Authors: Salti Talal, Khoury Mona, Awad Karem, Lerenthal Yaniv, Harari-Misgav Reut, Shemesh Ariel, Avraham-Kelbert Moran, Eitam Harel, Salvatore Campisi-Pinto, Abu-Amna Mahmoud, Colodner Raul, Tovbin David, Bar-Sela Gil and Cohen Idan
    Citation: BMC Medicine 2022 20:364
  23. Dose fractionation of a coronavirus disease 2019 (COVID-19) vaccine could effectively accelerate global vaccine coverage, while supporting evidence of efficacy, immunogenicity, and safety are unavailable, espe...

    Authors: Bingyi Yang, Xiaotong Huang, Huizhi Gao, Nancy H. Leung, Tim K. Tsang and Benjamin J. Cowling
    Citation: BMC Medicine 2022 20:409
  24. Dual inhibition of PD-1/PD-L1 and TGF-β pathways is a rational therapeutic strategy for malignancies. SHR-1701 is a new bifunctional fusion protein composed of a monoclonal antibody against PD-L1 fused with th...

    Authors: Dan Liu, Jun Zhou, Yongsheng Wang, Mingjun Li, Haiping Jiang, Yunpeng Liu, Xianli Yin, Minghua Ge, Xiaojun Xiang, Jieer Ying, Jian Huang, Yan-qiao Zhang, Ying Cheng, Zhigang Huang, Xianglin Yuan, Weiqing Han…
    Citation: BMC Medicine 2022 20:408
  25. For hypertensive patients without a history of stroke or myocardial infarction (MI), the China Stroke Primary Prevention Trial (CSPPT) demonstrated that treatment with enalapril-folic acid reduced the risk of ...

    Authors: Tiantian Zhang, Zhuoru Liang, Tengfei Lin, David J. Cohen, Alejandro Arrieta, Xiaobin Wang, Xianhui Qin, Binyan Wang, Yong Huo, Gordon G. Liu, Jie Jiang and Zugui Zhang
    Citation: BMC Medicine 2022 20:407
  26. Circulating tumor DNA (ctDNA) has been proven to be a promising tumor-specific biomarker in solid tumors, but its clinical utility in risk stratification and early prediction of relapse for diffuse large B cel...

    Authors: Miaomiao Li, Lan Mi, Chunyang Wang, Xiaojuan Wang, Jianhua Zhu, Fei Qi, Hui Yu, Yingying Ye, Dedao Wang, Jiaowu Cao, Dingyao Hu, Quanyu Yang, Dandan Zhao, Tonghui Ma, Yuqin Song and Jun Zhu
    Citation: BMC Medicine 2022 20:369
  27. Abnormal metabolism and perturbations in metabolic pathways play significant roles in the development and progression of prostate cancer; however, comprehensive metabolomic analyses of human data are lacking a...

    Authors: Jiaqi Huang, Bin Zhao, Stephanie J. Weinstein, Demetrius Albanes and Alison M. Mondul
    Citation: BMC Medicine 2022 20:362
  28. The diagnostic accuracy of unsupervised self-testing with rapid antigen diagnostic tests (Ag-RDTs) is mostly unknown. We studied the diagnostic accuracy of a self-performed SARS-CoV-2 saliva and nasal Ag-RDT i...

    Authors: Ewoud Schuit, Roderick P. Venekamp, Irene K. Veldhuijzen, Wouter van den Bijllaardt, Suzan D. Pas, Joep J. J. M. Stohr, Esther B. Lodder, Marloes Hellwich, Richard Molenkamp, Zsofia Igloi, Constantijn Wijers, Irene H. Vroom, Carla R. S. Nagel-Imming, Wanda G. H. Han, Jan A. J. W. Kluytmans, Susan van den Hof…
    Citation: BMC Medicine 2022 20:406
  29. The ongoing opioid epidemic and increases in alcohol-related mortality are key public health concerns in the USA, with well-documented inequalities in the degree to which groups with low and high education are...

    Authors: Charlotte Buckley, Yu Ye, William C. Kerr, Nina Mulia, Klajdi Puka, Jürgen Rehm and Charlotte Probst
    Citation: BMC Medicine 2022 20:405
  30. Parallel to growth of aging and obese populations, the prevalence of metabolic diseases is rising. How body mass index (BMI) relates to frailty and mortality across frailty levels is controversial. We examined...

    Authors: Kulapong Jayanama, Olga Theou, Judith Godin, Andrea Mayo, Leah Cahill and Kenneth Rockwood
    Citation: BMC Medicine 2022 20:404
  31. Although neoadjuvant anti-PD-1 immunotherapies have shown good efficacy in non-small cell lung cancer (NSCLC) patients, there is still a lack of effective predictive markers. We aimed to develop a pretreatment...

    Authors: Pei Yuan, Changyuan Guo, Lin Li, Yun Ling, Lei Guo and Jianming Ying
    Citation: BMC Medicine 2022 20:403
  32. To investigate whether metformin monotherapy or adjunctive therapy improves the prognosis in patients with any type of cancer compared to non-metformin users (age ≥18).

    Authors: Jie Wen, Zhenjie Yi, Yuyao Chen, Jing Huang, Xueyi Mao, Liyang Zhang, Yu Zeng, Quan Cheng, Wenrui Ye, Zhixiong Liu, Fangkun Liu and Jingfang Liu
    Citation: BMC Medicine 2022 20:402
  33. Structured and harmonized implementation of molecular tumor boards (MTB) for the clinical interpretation of molecular data presents a current challenge for precision oncology. Heterogeneity in the interpretati...

    Authors: Damian T. Rieke, Till de Bortoli, Peter Horak, Mario Lamping, Manuela Benary, Ivan Jelas, Gina Rüter, Johannes Berger, Marit Zettwitz, Niklas Kagelmann, Andreas Kind, Falk Fabian, Dieter Beule, Hanno Glimm, Benedikt Brors, Albrecht Stenzinger…
    Citation: BMC Medicine 2022 20:367
  34. Randomized controlled trials (RCTs) and cohort studies are the most common study design types used to assess treatment effects of medical interventions. We aimed to hypothetically pool bodies of evidence (BoE)...

    Authors: Nils Bröckelmann, Julia Stadelmaier, Louisa Harms, Charlotte Kubiak, Jessica Beyerbach, Martin Wolkewitz, Jörg J. Meerpohl and Lukas Schwingshackl
    Citation: BMC Medicine 2022 20:355
  35. The severe fever with thrombocytopenia syndrome disease (SFTS), caused by the novel tick-borne SFTS virus (SFTSV), was listed among the top 10 priority infectious disease by World Health Organization due to th...

    Authors: Shu Shen, Yaxian Zhang, Zhiyun Yin, Qiong Zhu, Jingyuan Zhang, Tiantian Wang, Yaohui Fang, Xiaoli Wu, Yuan Bai, Shiyu Dai, Xijia Liu, Jiayin Jin, Shuang Tang, Jia Liu, Manli Wang, Yu Guo…
    Citation: BMC Medicine 2022 20:359
  36. Authors: Amadea Turk, Geoffrey Wong, Kamal R. Mahtani, Michelle Maden, Ruaraidh Hill, Ed Ranson, Emma Wallace, Janet Krska, Dee Mangin, Richard Byng, Daniel Lasserson and Joanne Reeve
    Citation: BMC Medicine 2022 20:401

    The original article was published in BMC Medicine 2022 20:297

  37. Limited data are available on the effectiveness of inactivated and Ad5-nCoV COVID-19 vaccines in real-world use—especially against Omicron variants in SARS-CoV-2 infection-naïve population.

    Authors: Zhuoying Huang, Shuangfei Xu, Jiechen Liu, Linlin Wu, Jing Qiu, Nan Wang, Jia Ren, Zhi Li, Xiang Guo, Fangfang Tao, Jian Chen, Donglei Lu, Xiaodong Sun and Weibing Wang
    Citation: BMC Medicine 2022 20:400
  38. Reduced androgen action during early fetal development has been suggested as the origin of reproductive disorders comprised within the testicular dysgenesis syndrome (TDS). This hypothesis has been supported b...

    Authors: Malene Lundgaard Riis, Gabriele Matilionyte, John E. Nielsen, Cecilie Melau, David Greenald, Kristine Juul Hare, Lea Langhoff Thuesen, Eva Dreisler, Kasper Aaboe, Pia Tutein Brenøe, Anna-Maria Andersson, Jakob Albrethsen, Hanne Frederiksen, Ewa Rajpert-De Meyts, Anders Juul, Rod T. Mitchell…
    Citation: BMC Medicine 2022 20:399
  39. Maternal blood pressure levels reflect cardiovascular adaptation to pregnancy and proper maternal-fetal exchanges through the placenta and are very sensitive to numerous environmental stressors. Maternal hyper...

    Authors: Lucile Broséus, Daniel Vaiman, Jörg Tost, Camino Ruano San Martin, Milan Jacobi, Joel D. Schwartz, Rémi Béranger, Rémy Slama, Barbara Heude and Johanna Lepeule
    Citation: BMC Medicine 2022 20:397
  40. Health information and patient education on lifestyle changes may have a positive effect on the prevention of many chronic conditions, especially cardiovascular diseases (CVDs). We performed a parallel, three-...

    Authors: Slavica Jurić Petričević, Ivan Buljan, Dora Bjelanović, Nataša Mrduljaš-Đujić, Tanja Pekez, Mario Ćurković, Željko Vojvodić, Ivančica Pavličević, Matko Marušić and Ana Marušić
    Citation: BMC Medicine 2022 20:381
  41. The benefits and risks of intensive versus standard systolic blood pressure (SBP) treatment in older patients with arterial stiffness (AS) remains unclear. This study aims to investigate the interaction betwee...

    Authors: Qirui Song, Qianhui Ling, Jingjing Bai, Hongwei Zhang, Peili Bu, Fang Chen, Shouling Wu, Weili Zhang, Mulei Chen and Jun Cai
    Citation: BMC Medicine 2022 20:358
  42. Radiotherapy (RT) is one of the major therapeutic approaches to hepatocellular carcinoma (HCC). Ionizing radiation (IR) inducing the generation of reactive oxygen species (ROS) leads to a promising antitumor e...

    Authors: Yizhi Zhan, Zhanqiao Zhang, Yuechen Liu, Yuan Fang, Yuwen Xie, Yilin Zheng, Guoxin Li, Li Liang and Yi Ding
    Citation: BMC Medicine 2022 20:365
  43. Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metaboli...

    Authors: Marie Breeur, Pietro Ferrari, Laure Dossus, Mazda Jenab, Mattias Johansson, Sabina Rinaldi, Ruth C. Travis, Mathilde His, Tim J. Key, Julie A. Schmidt, Kim Overvad, Anne Tjønneland, Cecilie Kyrø, Joseph A. Rothwell, Nasser Laouali, Gianluca Severi…
    Citation: BMC Medicine 2022 20:351
  44. Acute febrile respiratory illness (AFRI) patients are susceptible to pneumonia and suffer from significant morbidity and mortality throughout the world. In primary care settings, the situation is worse. Limite...

    Authors: Fengming Ding, Lei Han, Dongning Yin, Yan Zhou, Yong Ji, Pengyu Zhang, Wensheng Wu, Jijing Chen, Zufang Wang, Xinxin Fan, Guoqing Zhang and Min Zhang
    Citation: BMC Medicine 2022 20:360
  45. The prevention of type 2 diabetes is challenging due to the variable effects of risk factors at an individual level. Data-driven methods could be useful to detect more homogeneous groups based on risk factor v...

    Authors: Diego Yacamán Méndez, Minhao Zhou, Ylva Trolle Lagerros, Donaji V. Gómez Velasco, Per Tynelius, Hrafnhildur Gudjonsdottir, Antonio Ponce de Leon, Katarina Eeg-Olofsson, Claes-Göran Östenson, Boel Brynedal, Carlos A. Aguilar Salinas, David Ebbevi and Anton Lager
    Citation: BMC Medicine 2022 20:356
  46. Considering the heterogeneity of tumors, it is a key issue in precision medicine to predict the drug response of each individual. The accumulation of various types of drug informatics and multi-omics data faci...

    Authors: Xiaoxiao Cheng, Chong Dai, Yuqi Wen, Xiaoqi Wang, Xiaochen Bo, Song He and Shaoliang Peng
    Citation: BMC Medicine 2022 20:368
  47. Extraintestinal symptoms are common in inflammatory bowel diseases (IBD) and include depression and fatigue. These are highly prevalent especially in active disease, potentially due to inflammation-mediated ch...

    Authors: Anne Kerstin Thomann, Torsten Wüstenberg, Jakob Wirbel, Laura-Louise Knoedler, Philipp Arthur Thomann, Georg Zeller, Matthias Philip Ebert, Stefanie Lis and Wolfgang Reindl
    Citation: BMC Medicine 2022 20:366