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  1. The interplay among the plant-based dietary pattern, gut microbiota, and cardiometabolic health is still unclear, and evidence from large prospective cohorts is rare. We aimed to examine the association of lon...

    Authors: Zelei Miao, Wenwen Du, Congmei Xiao, Chang Su, Wanglong Gou, Luqi Shen, Jiguo Zhang, Yuanqing Fu, Zengliang Jiang, Zhihong Wang, Xiaofang Jia, Ju-Sheng Zheng and Huijun Wang
    Citation: BMC Medicine 2022 20:204
  2. The epidemiological international landscape of traumatic spinal cord injury (SCI) has evolved over the last decades along with given inherent differences in acute care and rehabilitation across countries and j...

    Authors: Lucie Bourguignon, Bobo Tong, Fred Geisler, Martin Schubert, Frank Röhrich, Marion Saur, Norbert Weidner, Rüdiger Rupp, Yorck-Bernhard B. Kalke, Rainer Abel, Doris Maier, Lukas Grassner, Harvinder S. Chhabra, Thomas Liebscher, Jacquelyn J. Cragg, John Kramer…
    Citation: BMC Medicine 2022 20:225
  3. Neurofilament light chain (NfL) is released into the blood during neuronal damage. NfL is linked to mortality in neurological disorders, remaining unexplored in population studies. We investigated whether init...

    Authors: May A. Beydoun, Nicole Noren Hooten, Jordan Weiss, Hind A. Beydoun, Sharmin Hossain, Michele K. Evans and Alan B. Zonderman
    Citation: BMC Medicine 2022 20:218
  4. Despite early interest in the health effects of polyunsaturated fatty acids (PUFA), there is still substantial controversy and uncertainty on the evidence linking PUFA to cardiovascular diseases (CVDs). We inv...

    Authors: Maria Carolina Borges, Philip C. Haycock, Jie Zheng, Gibran Hemani, Michael V. Holmes, George Davey Smith, Aroon D. Hingorani and Deborah A. Lawlor
    Citation: BMC Medicine 2022 20:210
  5. Epidemiological studies have demonstrated a favorable association of whole grain intake with coronary heart disease (CHD) risk, although whether such an inverse association holds true for individual whole grai...

    Authors: Yang Hu, Walter C. Willett, Jo Ann E. Manson, Bernard Rosner, Frank B. Hu and Qi Sun
    Citation: BMC Medicine 2022 20:192
  6. Chile was severely affected by COVID19 outbreaks but was also one of the first countries to start a nationwide program to vaccinate against the disease. Furthermore, Chile became one of the fastest countries t...

    Authors: Leonardo Vargas, Nicolás Valdivieso, Fabián Tempio, Valeska Simon, Daniela Sauma, Lucía Valenzuela, Caroll Beltrán, Loriana Castillo-Delgado, Ximena Contreras-Benavides, Mónica L. Acevedo, Johanna Acevedo, Rafael I. Gonzalez, Fernando Valiente-Echeverría, Ricardo Soto-Rifo, Mario Rosemblatt, Mercedes Lopez…
    Citation: BMC Medicine 2022 20:216
  7. Because most cervical cancers are caused by high-risk human papillomaviruses (hrHPVs), cervical cancer prevention programs increasingly employ hrHPV testing as a primary test. The high sensitivity of HPV tests...

    Authors: Karolina M. Andralojc, Duaa Elmelik, Menno Rasing, Bernard Pater, Albert G. Siebers, Ruud Bekkers, Martijn A. Huynen, Johan Bulten, Diede Loopik, Willem J. G. Melchers and William P. J. Leenders
    Citation: BMC Medicine 2022 20:206
  8. In Papua (Indonesia), infants with P. falciparum and/or P. vivax malaria are at risk of severe anaemia and death. We hypothesized that in an area of high malaria transmission, intermittent screening and treatment...

    Authors: Jeanne Rini Poespoprodjo, Hafiidhaturrahmah, Novita Sariyanti, Ratni Indrawanti, Alistair R. D. McLean, Julie A. Simpson, Enny Kenangalem, Faustina Helena Burdam, Rintis Noviyanti, Leily Trianty, Chairunisa Fadhilah, Yati Soenarto and Ric N. Price
    Citation: BMC Medicine 2022 20:190
  9. In current care, patients’ personal and self-reported family histories are primarily used to determine whether genetic testing for hereditary endocrine tumor syndromes (ETS) is indicated. Population genomic sc...

    Authors: Juliann M. Savatt, Nicole M. Ortiz, Gretchen M. Thone, Whitney S. McDonald, Melissa A. Kelly, Alexander S. F. Berry, Madiha M. Alvi, Miranda L. G. Hallquist, Jennifer Malinowski, Nicholas C. Purdy, Marc S. Williams, Amy C. Sturm and Adam H. Buchanan
    Citation: BMC Medicine 2022 20:205
  10. Body mass index (BMI) has been found to be associated with a decreased risk of non-small cell lung cancer (NSCLC); however, the effect of BMI trajectories and potential interactions with genetic variants on NS...

    Authors: Dongfang You, Danhua Wang, Yaqian Wu, Xin Chen, Fang Shao, Yongyue Wei, Ruyang Zhang, Theis Lange, Hongxia Ma, Hongyang Xu, Zhibin Hu, David C. Christiani, Hongbing Shen, Feng Chen and Yang Zhao
    Citation: BMC Medicine 2022 20:203
  11. Cardiometabolic multimorbidity (CM) is an increasing public health and clinical concern. However, predictors for the development and prognosis of CM are poorly understood. The aims of this study were to invest...

    Authors: Yanqiang Lu, Guochen Li, Pietro Ferrari, Heinz Freisling, Yanan Qiao, Luying Wu, Liping Shao and Chaofu Ke
    Citation: BMC Medicine 2022 20:191
  12. Muscle weakness, which increases in prevalence with age, is a major public health concern. Grip strength is commonly used to identify weakness and an improved understanding of its determinants is required. We ...

    Authors: Snehal M. Pinto Pereira, Victoria Garfield, Aliki-Eleni Farmaki, David J. Tomlinson, Thomas Norris, Ghazaleh Fatemifar, Spiros Denaxas, Chris Finan and Rachel Cooper
    Citation: BMC Medicine 2022 20:201
  13. Long-term morbidity after pediatric intensive care unit (PICU) admission is a growing concern. Both critical illness and accompanying PICU treatments may impact neurocognitive development as assessed by its go...

    Authors: Eleonore S. V. de Sonnaville, Marsh Kӧnigs, Ouke van Leijden, Hennie Knoester, Job B. M. van Woensel and Jaap Oosterlaan
    Citation: BMC Medicine 2022 20:198
  14. There is no consensus on the most efficient catheter ablation (CA) strategy for patients with atrial fibrillation (AF). The objective of this study was to compare the efficacy and safety of different CA strate...

    Authors: Emmanouil Charitakis, Silvia Metelli, Lars O. Karlsson, Antonios P. Antoniadis, Konstantinos D. Rizas, Ioan Liuba, Henrik Almroth, Anders Hassel Jönsson, Jonas Schwieler, Dimitrios Tsartsalis, Skevos Sideris, Elena Dragioti, Nikolaos Fragakis and Anna Chaimani
    Citation: BMC Medicine 2022 20:193
  15. Despite the reported efficacy of osimertinib, central nervous system (CNS) progression is still frequent in EGFR-mutated NSCLC. This study aimed to reveal site-specific resistant mechanisms to osimertinib and inv...

    Authors: Mei-Mei Zheng, Yang-Si Li, Hai-Yan Tu, Hao Sun, Kai Yin, Ben-Yuan Jiang, Jin-Ji Yang, Xu-Chao Zhang, Qing Zhou, Chong-Rui Xu, Zhen Wang, Hua-Jun Chen, De-Xiang Zhou and Yi-Long Wu
    Citation: BMC Medicine 2022 20:197
  16. Little is known regarding life-course trajectories of important diseases. We aimed to identify diseases that were strongly associated with mortality and test temporal trajectories of these diseases before mort...

    Authors: Xianwen Shang, Xueli Zhang, Yu Huang, Zhuoting Zhu, Xiayin Zhang, Shunming Liu, Jiahao Liu, Shulin Tang, Wei Wang, Honghua Yu, Zongyuan Ge and Mingguang He
    Citation: BMC Medicine 2022 20:185
  17. There is limited knowledge regarding the process of deprescribing psychotropic drugs to people with dementia (PwD) conducted by general practitioners (GP). We investigated the impact of a multicomponent interv...

    Authors: Marie H. Gedde, Bettina S. Husebo, Janne Mannseth, Mala Naik, Geir Selbaek, Maarja Vislapuu and Line Iden Berge
    Citation: BMC Medicine 2022 20:186
  18. Enhancer of zeste homolog 2 (EZH2)-mediated histone 3 lysine 27 trimethylation (H3K27me3) is a transcription silencing mark, which is indispensable for cell lineage specification at the early blastocyst stage....

    Authors: Ya-nan Zhu, Xiao-wen Gan, Fan Pan, Xiao-tian Ni, Leslie Myatt, Wang-sheng Wang and Kang Sun
    Citation: BMC Medicine 2022 20:189
  19. Long distance heavy goods vehicle (HGV) drivers exhibit higher than nationally representative rates of obesity, and obesity-related co-morbidities, and are underserved in terms of health promotion initiatives....

    Authors: Stacy A. Clemes, Veronica Varela-Mato, Danielle H. Bodicoat, Cassandra L. Brookes, Yu-Ling Chen, Charlotte L. Edwardson, Laura J. Gray, Amber J. Guest, Vicki Johnson, Fehmidah Munir, Nicola J. Paine, Gerry Richardson, Katharina Ruettger, Mohsen Sayyah, Aron Sherry, Ana Suazo Di Paola…
    Citation: BMC Medicine 2022 20:195
  20. Stroke is one of the major challenges for the global healthcare system, which makes it necessary to explore the relationship between various modifiable factors and stroke risk. Recently, numerous meta-analyses...

    Authors: Na Guo, Ying Zhu, Dandan Tian, Yating Zhao, Chenguang Zhang, Changqing Mu, Chen Han, Ruixia Zhu and Xu Liu
    Citation: BMC Medicine 2022 20:194
  21. Whether the associations of time spent in screen-based sedentary activities with CHD vary by genetic susceptibility is currently unknown. The objective of this study was to examine the interplay of genetic sus...

    Authors: Youngwon Kim, Shiu Lun Au Yeung, Stephen J. Sharp, Mengyao Wang, Haeyoon Jang, Shan Luo, Soren Brage and Katrien Wijndaele
    Citation: BMC Medicine 2022 20:188
  22. It was urgent and necessary to synthesize the evidence for vaccine effectiveness (VE) against SARS-CoV-2 variants of concern (VOC). We conducted a systematic review and meta-analysis to provide a comprehensive...

    Authors: Baoqi Zeng, Le Gao, Qingxin Zhou, Kai Yu and Feng Sun
    Citation: BMC Medicine 2022 20:200
  23. As we are confronted with more transmissible/severe variants with immune escape and the waning of vaccine efficacy, it is particularly relevant to understand how the social contacts of individuals at greater r...

    Authors: Aurélie Godbout, Mélanie Drolet, Myrto Mondor, Marc Simard, Chantal Sauvageau, Gaston De Serres and Marc Brisson
    Citation: BMC Medicine 2022 20:199
  24. Transparency and reproducibility are expected to be normative practices in clinical trials used for decision-making on marketing authorisations for new medicines. This registered report introduces a cross-sect...

    Authors: Maximilian Siebert, Jeanne Gaba, Alain Renault, Bruno Laviolle, Clara Locher, David Moher and Florian Naudet
    Citation: BMC Medicine 2022 20:177
  25. The temporal relationship between adiposity and gut microbiota was unexplored. Whether some gut microbes lie in the pathways from adiposity to insulin resistance is less clear. Our study aims to reveal the tem...

    Authors: Kui Deng, Menglei Shuai, Zheqing Zhang, Zengliang Jiang, Yuanqing Fu, Luqi Shen, Ju-Sheng Zheng and Yu-ming Chen
    Citation: BMC Medicine 2022 20:171
  26. Recent years have seen important improvements in available preventive treatment regimens for tuberculosis (TB), and research is ongoing to develop these further. To assist with the formulation of target produc...

    Authors: Juan F. Vesga, Christian Lienhardt, Placide Nsengiyumva, Jonathon R. Campbell, Olivia Oxlade, Saskia den Boon, Dennis Falzon, Kevin Schwartzman, Gavin Churchyard and Nimalan Arinaminpathy
    Citation: BMC Medicine 2022 20:182
  27. The ubiquity of Internet connectivity, and widespread unmet needs, requires investigations of digital interventions for people seeking help with their drinking. The objective of this study was to test the effe...

    Authors: Marcus Bendtsen, Katarina Åsberg and Jim McCambridge
    Citation: BMC Medicine 2022 20:176
  28. This study examines mental, neurological, and substance use (MNS) service usage within refugee camp primary health care facilities in low- and middle-income countries (LMICs) by analyzing surveillance data fro...

    Authors: Shoshanna L. Fine, Jeremy C. Kane, Paul B. Spiegel, Wietse A. Tol and Peter Ventevogel
    Citation: BMC Medicine 2022 20:183
  29. Cytokines have been reported to alter the response to immune checkpoint inhibitors (ICIs) in patients with the tumor in accordance with their plasma concentrations. Here, we aimed to identify the key cytokines...

    Authors: Chengming Liu, Lu Yang, Haiyan Xu, Sufei Zheng, Zhanyu Wang, Sihui Wang, Yaning Yang, Shuyang Zhang, Xiaoli Feng, Nan Sun, Yan Wang and Jie He
    Citation: BMC Medicine 2022 20:187

    The Correction to this article has been published in BMC Medicine 2022 20:265

  30. Fragile X syndrome (FXS), the most prevalent inherited intellectual disability and one of the most common monogenic forms of autism, is caused by a loss of fragile X messenger ribonucleoprotein 1 (FMR1). We ha...

    Authors: Sahar Javadi, Yue Li, Jie Sheng, Lucy Zhao, Yao Fu, Daifeng Wang and Xinyu Zhao
    Citation: BMC Medicine 2022 20:163
  31. Deregulation of cell-cycle pathway is ubiquitously observed in human papillomavirus negative (HPVneg) head and neck squamous cell carcinoma (HNSCC). Despite being an attractive target, CDK4/6 inhibition using pal...

    Authors: Ziyue Gu, Chaoji Shi, Jiayi Li, Yong Han, Bao Sun, Wuchang Zhang, Jing Wu, Guoyu Zhou, Weimin Ye, Jiang Li, Zhiyuan Zhang and Rong Zhou
    Citation: BMC Medicine 2022 20:175
  32. Randomized controlled trials (RCTs) and cohort studies are the most common study design types used to assess the treatment effects of medical interventions. To evaluate the agreement of effect estimates betwee...

    Authors: Nils Bröckelmann, Sara Balduzzi, Louisa Harms, Jessica Beyerbach, Maria Petropoulou, Charlotte Kubiak, Martin Wolkewitz, Joerg J. Meerpohl and Lukas Schwingshackl
    Citation: BMC Medicine 2022 20:174
  33. The association between vitamin E and cancer risk has been widely investigated by observational studies, but the findings remain inconclusive. Here, we aimed to evaluate the causal effect of circulating vitami...

    Authors: Junyi Xin, Xia Jiang, Shuai Ben, Qianyu Yuan, Li Su, Zhengdong Zhang, David C. Christiani, Mulong Du and Meilin Wang
    Citation: BMC Medicine 2022 20:168

    The Correction to this article has been published in BMC Medicine 2022 20:281

  34. Diverse genomic breakpoints of fusions that localize to intronic, exonic, or intergenic regions have been identified by DNA next-generation sequencing (NGS), but the role of exonic breakpoints remains elusive....

    Authors: Weihua Li, Rui Wan, Lei Guo, Geyun Chang, Dong Jiang, Lin Meng and Jianming Ying
    Citation: BMC Medicine 2022 20:160
  35. Thymic epithelial tumors (TETs) are rare malignancies and the treatment options are limited. We aimed to evaluate the efficacy and safety of apatinib, an angiogenesis inhibitor, in advanced TETs.

    Authors: Zhengbo Song, Guangyuan Lou, Yina Wang, Zhiping Yang, Wenxian Wang, Yongling Ji, Shiqing Chen, Chunwei Xu, Xiao Hu and Yiping Zhang
    Citation: BMC Medicine 2022 20:154
  36. Mobile and migrant populations (MMPs) pose a unique challenge to disease elimination campaigns as they are often hard to survey and reach with treatment. While some elimination efforts have had success reachin...

    Authors: Molly W Adams, Elizabeth G Sutherland, Erin L Eckert, Khalida Saalim and Richard Reithinger
    Citation: BMC Medicine 2022 20:172
  37. Identifying the causal genes at the risk loci and elucidating their roles in schizophrenia (SCZ) pathogenesis remain significant challenges. To explore risk variants associated with gene expression in the huma...

    Authors: Chengcheng Zhang, Xiaojing Li, Liansheng Zhao, Rong Liang, Wei Deng, Wanjun Guo, Qiang Wang, Xun Hu, Xiangdong Du, Pak Chung Sham, Xiongjian Luo and Tao Li
    Citation: BMC Medicine 2022 20:169
  38. Anlotinib, an oral small molecule tyrosine kinase inhibitor targeting VEGFR 1/2/3, FGFR 1-4, PDGFR a/β, and c-kit, had demonstrated prolonged progression-free survival (PFS) in refractory metastatic colorectal...

    Authors: Yue Liu, Qian Xiao, Jinjie He, Hanguang Hu, Jinlin Du, Yuping Zhu, Jiaqi Chen, Zhuo Liu, Jianping Wang, Lifeng Sun, Dong Xu, Jun Li, Xiujun Liao, Jianwei Wang, Yibo Cai, Cheng Cai…
    Citation: BMC Medicine 2022 20:155
  39. Previous studies of primarily Western populations have reported contrasting associations of dairy consumption with certain cancers, including a positive association with prostate cancer and inverse association...

    Authors: Maria G. Kakkoura, Huaidong Du, Yu Guo, Canqing Yu, Ling Yang, Pei Pei, Yiping Chen, Sam Sansome, Wing Ching Chan, Xiaoming Yang, Lei Fan, Jun Lv, Junshi Chen, Liming Li, Timothy J. Key and Zhengming Chen
    Citation: BMC Medicine 2022 20:134
  40. In non-small cell lung cancer (NSCLC) patients receiving immune checkpoint inhibitors (ICIs), higher blood tumor mutational burden (bTMB) was usually associated with better progression-free survival (PFS) and ...

    Authors: Wei Nie, Zhi-Jie Wang, Kai Zhang, Bing Li, Yi-Ran Cai, Feng-Cai Wen, Ding Zhang, Yue-Zong Bai, Xue-Yan Zhang, Shu-Yuan Wang, Lei Cheng, Hua Zhong, Li Liu, Jie Wang and Bao-Hui Han
    Citation: BMC Medicine 2022 20:170
  41. The association of adiposity with prostate cancer specific mortality remains unclear. We examined how adiposity relates to fatal prostate cancer and described the cross-sectional associations of commonly used ...

    Authors: Aurora Perez-Cornago, Yashvee Dunneram, Eleanor L. Watts, Timothy J. Key and Ruth C. Travis
    Citation: BMC Medicine 2022 20:143
  42. Practical guidance is needed regarding the vaccination of coronavirus disease 2019 (COVID-19) convalescent individuals in resource-limited countries. It includes the number of vaccine doses that should be give...

    Authors: Chang Kyung Kang, Hyun Mu Shin, Pyoeng Gyun Choe, Jiyoung Park, Jisu Hong, Jung Seon Seo, Yung Hie Lee, Euijin Chang, Nam Joong Kim, Minji Kim, Yong-Woo Kim, Hang-Rae Kim, Chang-Han Lee, Jun-Young Seo, Wan Beom Park and Myoung-don Oh
    Citation: BMC Medicine 2022 20:181
  43. Necrotising soft tissue infections (NSTIs) are rapidly progressing bacterial infections usually caused by either several pathogens in unison (polymicrobial infections) or Streptococcus pyogenes (mono-microbial in...

    Authors: Sanjeevan Jahagirdar, Lorna Morris, Nirupama Benis, Oddvar Oppegaard, Mattias Svenson, Ole Hyldegaard, Steinar Skrede, Anna Norrby-Teglund, Vitor A. P. Martins dos Santos and Edoardo Saccenti
    Citation: BMC Medicine 2022 20:173
  44. Recommended cardiovascular disease (CVD) prediction tools do not account for competing mortality risk and over-predict incident CVD in older and multimorbid people. The aim of this study was to derive and vali...

    Authors: Shona J. Livingstone, Bruce Guthrie, Peter T. Donnan, Alexander Thompson and Daniel R. Morales
    Citation: BMC Medicine 2022 20:152
  45. Effective targeted prevention of type 2 diabetes (T2D) depends on accurate prediction of disease risk. We assessed the role of metabolomic profiling in improving T2D risk prediction beyond conventional risk fa...

    Authors: Fiona Bragg, Eirini Trichia, Diego Aguilar-Ramirez, Jelena Bešević, Sarah Lewington and Jonathan Emberson
    Citation: BMC Medicine 2022 20:159