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  1. Mammographically dense breast tissue is one of the greatest risk factors for developing breast carcinoma. Despite the strong clinical correlation, breast density has not been causally linked to tumorigenesis, ...

    Authors: Paolo P Provenzano, David R Inman, Kevin W Eliceiri, Justin G Knittel, Long Yan, Curtis T Rueden, John G White and Patricia J Keely
    Citation: BMC Medicine 2008 6:11
  2. The dominantly inherited condition familial adenomatous polyposis (FAP) is caused by germline mutations in the APC gene. Finding the causative mutations has great implications for the families. Correlating the ge...

    Authors: Gunilla Kanter-Smoler, Kaisa Fritzell, Anna Rohlin, Yvonne Engwall, Birgitta Hallberg, Annika Bergman, Johan Meuller, Henrik Grönberg, Per Karlsson, Jan Björk and Margareta Nordling
    Citation: BMC Medicine 2008 6:10
  3. Home care plays a vital role in many health care systems, but there is evidence that appropriate targeting strategies must be used to allocate limited home care resources effectively. The aim of the present st...

    Authors: John P Hirdes, Jeff W Poss and Nancy Curtin-Telegdi
    Citation: BMC Medicine 2008 6:9
  4. Halfway through the 20th century, views on pain in labour encompassed almost everything from women's self-blame to blaming nurses, midwives, doctors or partners for 'bad experiences'. Soon after that, giving birt...

    Authors: Judith Lumley
    Citation: BMC Medicine 2008 6:8
  5. Childbirth is one of the most painful events that a woman is likely to experience, the multi-dimensional aspect and intensity of which far exceeds disease conditions. A woman's lack of knowledge about the risk...

    Authors: Joanne E Lally, Madeleine J Murtagh, Sheila Macphail and Richard Thomson
    Citation: BMC Medicine 2008 6:7
  6. Based on a large, representative unscreened cohort from Malmö, Sweden, we have recently reported that a single prostate-specific antigen (PSA) measurement at or before age 50 is a strong predictor of prostate ...

    Authors: David Ulmert, Angel M Cronin, Thomas Björk, Matthew F O'Brien, Peter T Scardino, James A Eastham, Charlotte Becker, Göran Berglund, Andrew J Vickers and Hans Lilja
    Citation: BMC Medicine 2008 6:6
  7. The UK General Medical Council has emphasized the lack of evidence on whether graduates from different UK medical schools perform differently in their clinical careers. Here we assess the performance of UK gra...

    Authors: IC McManus, Andrew T Elder, Andre de Champlain, Jane E Dacre, Jennifer Mollon and Liliana Chis
    Citation: BMC Medicine 2008 6:5
  8. In this study we investigated (a) to what extent physicians have experience with performing a range of end-of-life decisions (ELDs), (b) if they have no experience with performing an ELD, would they be willing...

    Authors: Rurik Löfmark, Tore Nilstun, Colleen Cartwright, Susanne Fischer, Agnes van der Heide, Freddy Mortier, Michael Norup, Lorenzo Simonato and Bregje D Onwuteaka-Philipsen
    Citation: BMC Medicine 2008 6:4
  9. Cameroon is one of 12 African countries that bear most of the global burden of yellow fever. In 2002 the country developed a five-year strategic plan for yellow fever control, which included strategies for pre...

    Authors: Charles Shey Wiysonge, Emmanuel Nomo, Jeanne Mawo, James Ofal, Julienne Mimbouga, Johnson Ticha and Peter M Ndumbe
    Citation: BMC Medicine 2008 6:3
  10. Outbreak reports suggest that community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections can be life-threatening. We conducted a population based cohort study to assess the magnitude of mort...

    Authors: JA 'Chris' Delaney, Verena Schneider-Lindner, Paul Brassard and Samy Suissa
    Citation: BMC Medicine 2008 6:2
  11. Although neuroanatomical and cognitive sequelae of low birthweight and preterm birth have been investigated, little is understood as to the likely prevalence of a history of low birthweight or preterm birth, o...

    Authors: Michael D Spencer, T William J Moorhead, Rod J Gibson, Andrew M McIntosh, Jessika ED Sussmann, David GC Owens, Stephen M Lawrie and Eve C Johnstone
    Citation: BMC Medicine 2008 6:1
  12. Some patients with long-standing low back pain will benefit from treatment with strong opioids. However, it would be helpful to predict which patients will have a good response. A fixed-term opioid trial has b...

    Authors: Eija Kalso, Karen H Simpson, Robert Slappendel, Joachim Dejonckheere and Ute Richarz
    Citation: BMC Medicine 2007 5:39
  13. Arthroscopy is often used to treat patients with chronic patellofemoral pain syndrome (PFPS). As there is a lack of evidence, we conducted a randomized controlled trial to study the efficacy of arthroscopy in ...

    Authors: Jyrki A Kettunen, Arsi Harilainen, Jerker Sandelin, Dietrich Schlenzka, Kalevi Hietaniemi, Seppo Seitsalo, Antti Malmivaara and Urho M Kujala
    Citation: BMC Medicine 2007 5:38
  14. Most Ministries of Health across Africa invest substantial resources in some form of health management information system (HMIS) to coordinate the routine acquisition and compilation of monthly treatment and a...

    Authors: Peter W Gething, Abdisalan M Noor, Catherine A Goodman, Priscilla W Gikandi, Simon I Hay, Shahnaaz K Sharif, Peter M Atkinson and Robert W Snow
    Citation: BMC Medicine 2007 5:37
  15. Minor and mild-major depression are highly prevalent in primary care. There is insufficient evidence for the effectiveness of antidepressants in the treatment of minor and mild-major depression. We compared th...

    Authors: Marleen LM Hermens, Hein PJ van Hout, Berend Terluin, Herman J Adèr, Brenda WJH Penninx, Harm WJ van Marwijk, Judith E Bosmans, Richard van Dyck and Marten de Haan
    Citation: BMC Medicine 2007 5:36
  16. Electron beam computed tomography (EBCT) is a method for measuring coronary calcification and has been promoted as a possible non-invasive screening/diagnostic tool for coronary artery disease (CAD). Our objec...

    Authors: Nandini Dendukuri, Keith Chiu and James M Brophy
    Citation: BMC Medicine 2007 5:35
  17. The global spread of the severe acute respiratory syndrome (SARS) epidemic has clearly shown the importance of considering the long-range transportation networks in the understanding of emerging diseases outbr...

    Authors: Vittoria Colizza, Alain Barrat, Marc Barthélemy and Alessandro Vespignani
    Citation: BMC Medicine 2007 5:34
  18. Kisspeptins and their G-protein coupled receptor, GPR54 are required for GnRH release and have been associated with anti-metastatic tumour cell behaviour in model systems. The latter might suggest that their o...

    Authors: Leah M Prentice, Christian Klausen, Steve Kalloger, Martin Köbel, Steven McKinney, Jennifer L Santos, Challayne Kenney, Erika Mehl, C Blake Gilks, Peter Leung, Ken Swenerton, David G Huntsman and Samuel AJ Aparicio
    Citation: BMC Medicine 2007 5:33
  19. Meta-analyses of N-acetylcysteine (NAC) for preventing contrast-induced nephrotoxicity (CIN) have led to disparate conclusions. Here we examine and attempt to resolve the heterogeneity evident among these trials.

    Authors: Denise A Gonzales, Kelly J Norsworthy, Steven J Kern, Steve Banks, Pamela C Sieving, Robert A Star, Charles Natanson and Robert L Danner
    Citation: BMC Medicine 2007 5:32
  20. Adolescent reproductive health has not continued to receive the attention it deserves since the start of the HIV epidemic. In South Africa, high numbers of adolescent women report pregnancies that are unwanted...

    Authors: Catherine MacPhail, Audrey E Pettifor, Sophie Pascoe and Helen V Rees
    Citation: BMC Medicine 2007 5:31
  21. Ranking of universities and institutions has attracted wide attention recently. Several systems have been proposed that attempt to rank academic institutions worldwide.

    Authors: John PA Ioannidis, Nikolaos A Patsopoulos, Fotini K Kavvoura, Athina Tatsioni, Evangelos Evangelou, Ioanna Kouri, Despina G Contopoulos-Ioannidis and George Liberopoulos
    Citation: BMC Medicine 2007 5:30
  22. Inactivated HVJ (hemagglutinating virus of Japan; Sendai virus) particles (HVJ envelope vector; HVJ-E can incorporate and deliver plasmid DNA, siRNA, antibody and peptide and anti-cancer drugs to cells both in vi...

    Authors: Hirokazu Kawano, Shintarou Komaba, Toshihide Kanamori and Yasufumi Kaneda
    Citation: BMC Medicine 2007 5:28
  23. Schistosomiasis and soil-transmitted helminthiasis (STH) are among the neglected tropical diseases in Africa. A national control program for these diseases was initiated in Uganda during March 2003. Annual tre...

    Authors: Yaobi Zhang, Artemis Koukounari, Narcis Kabatereine, Fiona Fleming, Francis Kazibwe, Edridah Tukahebwa, J Russell Stothard, Joanne P Webster and Alan Fenwick
    Citation: BMC Medicine 2007 5:27
  24. In the United Kingdom, specialist treatment and intervention services for doctors are underdeveloped. The MedNet programme, created in 1997 and funded by the London Deanery, aims to fill this gap by providing ...

    Authors: Antony I Garelick, Samantha R Gross, Irene Richardson, Matthias von der Tann, Julia Bland and Rob Hale
    Citation: BMC Medicine 2007 5:26
  25. Diabetes is known to be associated with cancer of the pancreas, though there is some debate as to whether it is a cause or a consequence of the disease. We investigated the incidence of pancreatic cancer in a ...

    Authors: MC Perrin, MB Terry, K Kleinhaus, L Deutsch, R Yanetz, E Tiram, R Calderon, Y Friedlander, O Paltiel and S Harlap
    Citation: BMC Medicine 2007 5:25
  26. The threat of a global influenza pandemic and the adoption of the World Health Organization (WHO) International Health Regulations (2005) highlight the value of well-coordinated, functional disease surveillanc...

    Authors: Helen N Perry, Sharon M McDonnell, Wondimagegnehu Alemu, Peter Nsubuga, Stella Chungong, Mac W Otten Jr, Paul S Lusamba-dikassa and Stephen B Thacker
    Citation: BMC Medicine 2007 5:24
  27. As socioeconomic health inequalities persist and widen, the health effects of adversity are a constant presence in the daily work of physicians. Gruen and colleagues suggest that, in responding to important po...

    Authors: John Furler, Elizabeth Harris, Mark Harris, Lucio Naccarella, Doris Young and Teri Snowdon
    Citation: BMC Medicine 2007 5:23
  28. There is growing evidence that gene-gene interactions are ubiquitous in determining the susceptibility to common human diseases. The investigation of such gene-gene interactions presents new statistical challe...

    Authors: Laurent Briollais, Yuanyuan Wang, Isaac Rajendram, Venus Onay, Ellen Shi, Julia Knight and Hilmi Ozcelik
    Citation: BMC Medicine 2007 5:22
  29. Statins are a class of medications that reduce cholesterol by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Whether statins can benefit patients with dementia remains unclear because of conflicti...

    Authors: Benjamin Wolozin, Stanley W Wang, Nien-Chen Li, Austin Lee, Todd A Lee and Lewis E Kazis
    Citation: BMC Medicine 2007 5:20
  30. Migraine aura may be difficult to differentiate from transient ischemic attacks and other transient neurological disorders in pregnant women. The aims of the present study were to investigate and diagnose all ...

    Authors: Janne Marit Ertresvg, Lars Jacob Stovner, Lene Ekern Kvavik, Hans-Jorgen Johnsen, John-Anker Zwart, Grethe Helde and Gunnar Bovim
    Citation: BMC Medicine 2007 5:19
  31. Duchenne muscular dystrophy results from mutation of the dystrophin gene, causing skeletal and cardiac muscle loss of function. The mdx mouse model of Duchenne muscular dystrophy is widely utilized to evaluate...

    Authors: Richard T Hinkle, Frank R Lefever, Elizabeth T Dolan, Deborah L Reichart, Jefferey A Dietrich, Kathryn E Gropp, Robert I Thacker, Jeffrey P Demuth, Paula J Stevens, Xiaoyan A Qu, Alex R Varbanov, Feng Wang and Robert J Isfort
    Citation: BMC Medicine 2007 5:18
  32. Peroxisome proliferator-activated receptors (PPARs) have emerged as important drug targets for diabetes. Drugs that activate PPARγ, such as the thiazolidinediones (TZDs), are widely used for treatment of Type ...

    Authors: Maria E Ramos-Nino, Charles D MacLean and Benjamin Littenberg
    Citation: BMC Medicine 2007 5:17
  33. The development of multidisciplinary team meetings (MDTMs) for radiology and pathology is a burgeoning area that increasingly impacts on work processes in both of these departments. The aim of this study was t...

    Authors: Bridget Kane, Saturnino Luz, D Sean O'Briain and Ronan McDermott
    Citation: BMC Medicine 2007 5:15
  34. Experts defined a "minimum medical knowledge" (MMK) that people need for understanding typical signs and/or risk factors of four relevant clinical conditions: myocardial infarction, stroke, chronic obstructive...

    Authors: Lucas M Bachmann, Florian S Gutzwiller, Milo A Puhan, Johann Steurer, Claudia Steurer-Stey and Gerd Gigerenzer
    Citation: BMC Medicine 2007 5:14
  35. Hepatic failure has been associated with reported therapeutic use of acetaminophen by alcoholic patients. The highest risk period for alcoholic patients is immediately after discontinuation of alcohol intake. ...

    Authors: EK Kuffner, JL Green, GM Bogdan, PC Knox, RB Palmer, K Heard, JT Slattery and RC Dart
    Citation: BMC Medicine 2007 5:13
  36. The CONSORT statement specifies the need for a balanced presentation of both benefits and harms of medical interventions in trial reports. However, invitations to screening and newspaper articles often emphasi...

    Authors: Karsten Juhl Jørgensen, Anders Klahn and Peter C Gøtzsche
    Citation: BMC Medicine 2007 5:12
  37. Although vaccination has been proved to be a safe, efficacious, and cost-effective intervention, immunisation rates remain suboptimal in many European countries, resulting in poor control of many vaccine-preve...

    Authors: Heinz-J Schmitt, Robert Booy, Robert Aston, Pierre Van Damme, R Fabian Schumacher, Magda Campins, Carlos Rodrigo, Terho Heikkinen, Catherine Weil-Olivier, Adam Finn, Per Olcén, David Fedson and Heikki Peltola
    Citation: BMC Medicine 2007 5:11
  38. In maternal medicine, research evidence is scattered making it difficult to access information for clinical decision making. Systematic reviews of good methodological quality are essential to provide valid inf...

    Authors: Lumaan Sheikh, Shelley Johnston, Shakila Thangaratinam, Mark D Kilby and Khalid S Khan
    Citation: BMC Medicine 2007 5:10
  39. Onchocerciasis is a leading cause of blindness worldwide, hence elimination of the infection is an important health priority. Community-based treatment programs with ivermectin form the basis of control progra...

    Authors: Juan Carlos Vieira, Philip J Cooper, Raquel Lovato, Tamara Mancero, Jorge Rivera, Roberto Proaño, Andrea A López, Ronald H Guderian and José Rumbea Guzmán
    Citation: BMC Medicine 2007 5:9
  40. Male students and students from ethnic minorities have been reported to underperform in undergraduate medical examinations. We examined the effects of ethnicity and gender on pass rates in UK medical graduates...

    Authors: Neil G Dewhurst, Chris McManus, Jennifer Mollon, Jane E Dacre and Allister J Vale
    Citation: BMC Medicine 2007 5:8
  41. To our knowledge, no study to date has investigated the prescribing patterns of immunomodulatory agents (IMAs) in an outpatient setting in the United States. To address this issue, we performed retrospective d...

    Authors: Jagannadha R Avasarala, Cormac A O'Donovan, Steve E Roach, Fabian Camacho and Steven R Feldman
    Citation: BMC Medicine 2007 5:6
  42. Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein, which acts as a chloride channel activated by cyclic AMP (cAMP). The mos...

    Authors: Isabelle Sermet-Gaudelus, Michel Renouil, Anne Fajac, Laure Bidou, Bastien Parbaille, Sébastien Pierrot, Nolwen Davy, Elise Bismuth, Philippe Reinert, Gérard Lenoir, Jean François Lesure, Jean Pierre Rousset and Aleksander Edelman
    Citation: BMC Medicine 2007 5:5

    The Correction to this article has been published in BMC Medicine 2018 16:159

  43. The need to publish corrections to scientific articles, and occasionally to retract them, has been recognized for decades. However very little emphasis has been attached to how this is done, provided that the ...

    Authors: Melissa L Norton and Deborah C Saltman
    Citation: BMC Medicine 2007 5:4
  44. Because training of the lumbar muscles is a commonly recommended intervention in low back pain (LBP), it is important to clarify whether lumbar muscle atrophy is related to LBP. Fat infiltration seems to be a ...

    Authors: Per Kjaer, Tom Bendix, Joan Solgaard Sorensen, Lars Korsholm and Charlotte Leboeuf-Yde
    Citation: BMC Medicine 2007 5:2
  45. The increased sympathetic nervous activity in patients with obstructive sleep apnea (OSA) is largely responsible for the high prevalence of arterial hypertension, and it is suggested to adversely affect trigly...

    Authors: Nina K Bartels, Jan Börgel, Stefan Wieczorek, Nikolaus Büchner, Christoph Hanefeld, Daniel Bulut, Andreas Mügge, Lars C Rump, Bernd M Sanner and Jörg T Epplen
    Citation: BMC Medicine 2007 5:1