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  1. Nearly a third of children in the UK are overweight, with the prevalence in the most deprived areas more than twice that in the least deprived. The aim was to develop a risk identification model for childhood ...

    Authors: Nida Ziauddeen, Sam Wilding, Paul J. Roderick, Nicholas S. Macklon, Dianna Smith, Debbie Chase and Nisreen A. Alwan
    Citation: BMC Medicine 2020 18:105
  2. Many decisions regarding health resource utilization flow through the patient-clinician interaction. Thus, it represents a place where de-implementation interventions may have considerable effect on reducing t...

    Authors: Emma E. Sypes, Chloe de Grood, Liam Whalen-Browne, Fiona M. Clement, Jeanna Parsons Leigh, Daniel J. Niven and Henry T. Stelfox
    Citation: BMC Medicine 2020 18:116
  3. To mitigate and slow the spread of COVID-19, many countries have adopted unprecedented physical distancing policies, including the UK. We evaluate whether these measures might be sufficient to control the epid...

    Authors: Christopher I. Jarvis, Kevin Van Zandvoort, Amy Gimma, Kiesha Prem, Petra Klepac, G. James Rubin and W. John Edmunds
    Citation: BMC Medicine 2020 18:124
  4. Compared to adults, there are relatively few studies on COVID-19 infection in children, and even less focusing on the unique features of COVID-19 in children in terms of laboratory findings, locations of compu...

    Authors: Huijing Ma, Jiani Hu, Jie Tian, Xi Zhou, Hui Li, Maxwell Thomas Laws, Luke David Wesemann, Baiqi Zhu, Wei Chen, Rafael Ramos, Jun Xia and Jianbo Shao
    Citation: BMC Medicine 2020 18:123

    The Commentary to this article has been published in BMC Medicine 2020 18:171

    The Commentary to this article has been published in BMC Medicine 2020 18:158

  5. There is a decreasing trend in the proportion of individuals who perceive e-cigarettes to be less harmful than conventional cigarettes across the UK, Europe and the US. It is important to assess whether this m...

    Authors: Olga Perski, Emma Beard and Jamie Brown
    Citation: BMC Medicine 2020 18:98
  6. Beta-blockers are widely used for many cardiovascular conditions; however, their efficacy in contemporary clinical practice remains uncertain.

    Authors: Oliver J. Ziff, Monica Samra, James P. Howard, Daniel I. Bromage, Frank Ruschitzka, Darrel P. Francis and Dipak Kotecha
    Citation: BMC Medicine 2020 18:103
  7. For years, the benefits of septoplasty have been questioned. Due to the scarce and inconclusive literature, several National Health Service (NHS) Clinical Commissioning Groups in England decided to add septal ...

    Authors: M. M. H. T. van Egmond, J. P. C. Grutters, G. Hannink, N. van Heerbeek and M. M. Rovers
    Citation: BMC Medicine 2020 18:101
  8. Antidepressants may be used to manage a number of conditions in children and young people including depression, anxiety, and obsessive-compulsive disorder. UK guidelines for the treatment of depression in chil...

    Authors: Ruth H. Jack, Rebecca M. Joseph, Carol Coupland, Debbie Butler, Chris Hollis, Richard Morriss, Roger David Knaggs, Andrea Cipriani, Samuele Cortese and Julia Hippisley-Cox
    Citation: BMC Medicine 2020 18:93

    The Correspondence to this article has been published in BMC Medicine 2023 21:346

    The Correspondence to this article has been published in BMC Medicine 2023 21:345

    The Commentary to this article has been published in BMC Medicine 2020 18:150

  9. The most widely used measures of declining burden of malaria across sub-Saharan Africa are predictions from geospatial models. These models apply spatiotemporal autocorrelations and covariates to parasite prev...

    Authors: Alice Kamau, Polycarp Mogeni, Emelda A. Okiro, Robert W. Snow and Philip Bejon
    Citation: BMC Medicine 2020 18:94
  10. Most of the world’s sickle cell disease (SCD) burden is in Africa, where it is a major contributor to child morbidity and mortality. Despite the low cost of many preventive SCD interventions, insufficient reso...

    Authors: Assaf P. Oron, Dennis L. Chao, Echezona E. Ezeanolue, Loveth N. Ezenwa, Frédéric B. Piel, Osifo Telison Ojogun, Sophie Uyoga, Thomas N. Williams and Obiageli E. Nnodu
    Citation: BMC Medicine 2020 18:92
  11. The 2018–2019 Ebola virus disease (EVD) outbreak in North Kivu and Ituri provinces in the Democratic Republic of the Congo (DRC) is the largest ever recorded in the DRC. It has been declared a Public Health Em...

    Authors: Moritz U. G. Kraemer, David M. Pigott, Sarah C. Hill, Samantha Vanderslott, Robert C. Reiner Jr, Stephanie Stasse, John S. Brownstein, Bernardo Gutierrez, Francis Dennig, Simon I. Hay, G. R. William Wint, Oliver G. Pybus, Marcia C. Castro, Patrick Vinck, Phuong N. Pham, Eric J. Nilles…
    Citation: BMC Medicine 2020 18:113
  12. Recent efforts to address the obesity epidemic have focused on sugar consumption, especially sugar-sweetened beverages. However, sugar takes many forms, is only one contributor to overall energy consumption an...

    Authors: Jana J. Anderson, Stuart R. Gray, Paul Welsh, Daniel F. Mackay, Carlos A. Celis-Morales, Donald M. Lyall, John Forbes, Naveed Sattar, Jason M. R. Gill and Jill P. Pell
    Citation: BMC Medicine 2020 18:97

    The Commentary to this article has been published in BMC Medicine 2020 18:112

  13. To reduce inappropriate antibiotic use, public health campaigns often provide fear-based information about antimicrobial resistance (AMR). Meta-analyses have found that fear-based campaigns in other contexts a...

    Authors: Laurence S. J. Roope, Sarah Tonkin-Crine, Natalie Herd, Susan Michie, Koen B. Pouwels, Enrique Castro-Sanchez, Anna Sallis, Susan Hopkins, Julie V. Robotham, Derrick W. Crook, Tim Peto, Michele Peters, Christopher C. Butler, A. Sarah Walker and Sarah Wordsworth
    Citation: BMC Medicine 2020 18:110

    The Commentary to this article has been published in BMC Medicine 2020 18:108

  14. The recent emergence of strains belonging to the meningococcal serogroup W (MenW) sequence type-11 clonal complex and descending from the South American sub-lineage (MenW:cc11/SA) has caused significant shifts...

    Authors: Matthieu Domenech de Cellès, Helen Campbell, Ray Borrow, Muhamed-Kheir Taha and Lulla Opatowski
    Citation: BMC Medicine 2020 18:109
  15. When a journal receives a duplicate publication, the ability to identify the submitted work as previously published, and reject it, is an assay to publication ethics best practices. The aim of this study was t...

    Authors: Kelly D. Cobey, Danielle B. Rice, Manoj M. Lalu, Daniel Abramowitz, Nadera Ahmadzai, Heather Cunningham, Ana Patricia Ayala, Hana Raffoul, Faizan Khan, Larissa Shamseer and David Moher
    Citation: BMC Medicine 2020 18:88
  16. A number of studies have reported an association between the occurrence of immune-related adverse events (irAEs) and clinical efficacy in patients undergoing treatment with immune checkpoint inhibitors (ICIs),...

    Authors: Xiaoxiang Zhou, Zhuoran Yao, Huaxia Yang, Naixin Liang, Xuan Zhang and Fengchun Zhang
    Citation: BMC Medicine 2020 18:87

    The Commentary to this article has been published in BMC Medicine 2020 18:111

  17. The clinical pathway to detect and diagnose prostate cancer has been revolutionised by the use of multiparametric MRI (mpMRI pre-biopsy). mpMRI however remains a resource-intensive test and is highly operator ...

    Authors: Lois Kim, Nicholas Boxall, Anne George, Keith Burling, Pete Acher, Jonathan Aning, Stuart McCracken, Toby Page and Vincent J. Gnanapragasam
    Citation: BMC Medicine 2020 18:95
  18. Trials have shown total diet replacement (TDR) programmes are safe and effective for weight loss in primary care. However, it is not clear whether participant characteristics affect uptake, attendance, or effe...

    Authors: Nerys M. Astbury, Kate Tudor, Paul Aveyard and Susan A. Jebb
    Citation: BMC Medicine 2020 18:86
  19. Sepsis is a leading cause of death in intensive care units (ICUs), but outcomes of individual patients are difficult to predict. The recently developed clinical metabolomics has been recognized as a promising ...

    Authors: Jing Wang, Yizhu Sun, Shengnan Teng and Kefeng Li
    Citation: BMC Medicine 2020 18:83
  20. China has an aging population with an increasing number of adults aged ≥ 60 years. Influenza causes a heavy disease burden in older adults, but can be alleviated by vaccination. We assessed the cost-effectiven...

    Authors: Juan Yang, Katherine E. Atkins, Luzhao Feng, Marc Baguelin, Peng Wu, Han Yan, Eric H. Y. Lau, Joseph T. Wu, Yang Liu, Benjamin J. Cowling, Mark Jit and Hongjie Yu
    Citation: BMC Medicine 2020 18:90
  21. Patient and public involvement (PPI) in research envisages a relationship built throughout the lifespan of a research project between academics, clinicians and PPI colleagues in order to inform, plan, execute ...

    Authors: Tracy Jackson, Hilary Pinnock, Su May Liew, Elsie Horne, Elisabeth Ehrlich, Olivia Fulton, Allison Worth, Aziz Sheikh and Anna De Simoni
    Citation: BMC Medicine 2020 18:79
  22. Multimorbidity is associated with mortality and service use, with specific types of multimorbidity having differential effects. Additionally, multimorbidity is often negatively associated with participation in...

    Authors: Yajing Zhu, Duncan Edwards, Jonathan Mant, Rupert A. Payne and Steven Kiddle
    Citation: BMC Medicine 2020 18:78
  23. Chronic kidney disease with metabolic acidosis is common in older people, but the effectiveness of oral sodium bicarbonate therapy in this group is unclear. We tested whether oral sodium bicarbonate provides n...

    Authors:
    Citation: BMC Medicine 2020 18:91
  24. The past decades of research have seen an increase in statistical tools to explore the complex dynamics of mental health from patient data, yet the application of these tools in clinical practice remains uncom...

    Authors: Julian Burger, Date C. van der Veen, Donald J. Robinaugh, Rick Quax, Harriëtte Riese, Robert A. Schoevers and Sacha Epskamp
    Citation: BMC Medicine 2020 18:99
  25. Mental ill-health in health professionals, including doctors, is a global and growing concern. The existing literature on interventions that offer support, advice and/or treatment to sick doctors has not yet b...

    Authors: Daniele Carrieri, Karen Mattick, Mark Pearson, Chrysanthi Papoutsi, Simon Briscoe, Geoff Wong and Mark Jackson
    Citation: BMC Medicine 2020 18:76
  26. Preterm birth, small size for gestational age (SGA) and large size for gestational age (LGA) at birth are major risk factors for neonatal and long-term morbidity and mortality. It is unclear which periods of p...

    Authors: Jan S. Erkamp, Ellis Voerman, Eric A. P. Steegers, Annemarie G. M. G. J. Mulders, Irwin K. M. Reiss, Liesbeth Duijts, Vincent W. V. Jaddoe and Romy Gaillard
    Citation: BMC Medicine 2020 18:63
  27. Respiratory syncytial virus (RSV) frequently causes acute lower respiratory infection in children under 5, representing a high burden in Gavi-eligible countries (mostly low-income and lower-middle-income). Sin...

    Authors: Xiao Li, Lander Willem, Marina Antillon, Joke Bilcke, Mark Jit and Philippe Beutels
    Citation: BMC Medicine 2020 18:82
  28. Education is widely associated with better physical and mental health, but isolating its causal effect is difficult because education is linked with many socioeconomic advantages. One way to isolate education’...

    Authors: Jessica Butler, Corri Black, Peter Craig, Chris Dibben, Ruth Dundas, Michelle Hilton Boon, Marjorie Johnston and Frank Popham
    Citation: BMC Medicine 2020 18:77
  29. Infective endocarditis is an uncommon but serious infection, where evidence for giving antibiotic prophylaxis before invasive dental procedures is inconclusive. In England, antibiotic prophylaxis was offered r...

    Authors: T. Phuong Quan, Berit Muller-Pebody, Nicola Fawcett, Bernadette C. Young, Mehdi Minaji, Jonathan Sandoe, Susan Hopkins, Derrick Crook, Timothy Peto, Alan P. Johnson and A. Sarah Walker
    Citation: BMC Medicine 2020 18:84
  30. Transdiagnostic processes confer risk for multiple types of psychopathology and explain the co-occurrence of different disorders. For this reason, transdiagnostic processes provide ideal targets for early inte...

    Authors: Katie A. McLaughlin, Natalie L. Colich, Alexandra M. Rodman and David G. Weissman
    Citation: BMC Medicine 2020 18:96
  31. Preterm delivery is an independent risk factor for maternal cardiovascular disease. Little is known about the association between preterm delivery and maternal renal function. This study aimed to examine wheth...

    Authors: Peter M. Barrett, Fergus P. McCarthy, Marie Evans, Marius Kublickas, Ivan J. Perry, Peter Stenvinkel, Karolina Kublickiene and Ali S. Khashan
    Citation: BMC Medicine 2020 18:66
  32. The risks of harms from opioids increase substantially at high doses, and high-dose prescribing has increased in primary care. However, little is known about what leads to high-dose prescribing, and studies ex...

    Authors: Georgia C. Richards, Kamal R. Mahtani, Tonny B. Muthee, Nicholas J. DeVito, Constantinos Koshiaris, Jeffrey K. Aronson, Ben Goldacre and Carl J. Heneghan
    Citation: BMC Medicine 2020 18:68
  33. The highest burden of hypertension is found in Sub-Saharan Africa (SSA) with a threefold greater mortality from stroke and other associated diseases. Ethnicity is known to influence the response to antihyperte...

    Authors: Anna Seeley, Josephine Prynn, Rachel Perera, Rebecca Street, Daniel Davis and Anthony O. Etyang
    Citation: BMC Medicine 2020 18:75
  34. We recently published in BMC Medicine an evaluation of the comparative diagnostic performance of InSilicoVA, a software to map the underlying causes of death from verbal autopsy interviews. The developers of this...

    Authors: Abraham D. Flaxman, Riley Hazard, Ian Riley, Alan D. Lopez and Christopher J. L. Murray
    Citation: BMC Medicine 2020 18:73

    The original article was published in BMC Medicine 2018 16:56

    The Correspondence to this article has been published in BMC Medicine 2020 18:69

  35. A verbal autopsy (VA) is an interview conducted with the caregivers of someone who has recently died to describe the circumstances of the death. In recent years, several algorithmic methods have been developed...

    Authors: Zehang Richard Li, Tyler H. McCormick and Samuel J. Clark
    Citation: BMC Medicine 2020 18:69

    The Correspondence to this article has been published in BMC Medicine 2020 18:73

    The Research article to this article has been published in BMC Medicine 2018 16:56

  36. Immunological damage in acute HIV infection (AHI) may predispose to detrimental clinical sequela. However, studies on the earliest HIV-induced immunological changes are limited, particularly in sub-Saharan Afr...

    Authors: Daniel M. Muema, Ngomu A. Akilimali, Okechukwu C. Ndumnego, Sipho S. Rasehlo, Raveshni Durgiah, Doty B.A. Ojwach, Nasreen Ismail, Mary Dong, Amber Moodley, Krista L. Dong, Zaza M. Ndhlovu, Jenniffer M. Mabuka, Bruce D. Walker, Jaclyn K. Mann and Thumbi Ndung’u
    Citation: BMC Medicine 2020 18:81
  37. Diagnosing polycystic ovary syndrome (PCOS) during adolescence is challenging because features of normal pubertal development overlap with adult diagnostic criteria. The international evidence-based PCOS Guide...

    Authors: Alexia S. Peña, Selma F. Witchel, Kathleen M. Hoeger, Sharon E. Oberfield, Maria G. Vogiatzi, Marie Misso, Rhonda Garad, Preeti Dabadghao and Helena Teede
    Citation: BMC Medicine 2020 18:72
  38. Age at menarche has been associated with various health outcomes. We aimed to identify potential causal effects of age at menarche on health-related traits in a hypothesis-free manner.

    Authors: Maria C. Magnus, Anna L. Guyatt, Rebecca B. Lawn, Annah B. Wyss, Katerina Trajanoska, Leanne K. Küpers, Fernando Rivadeneira, Martin D. Tobin, Stephanie J. London, Debbie A. Lawlor, Louise A. C. Millard and Abigail Fraser
    Citation: BMC Medicine 2020 18:71
  39. Geographical inequalities in overweight and obesity prevalence among children are well established in cross-sectional research. We aimed to examine how environmental area characteristics at birth are related t...

    Authors: Sam Wilding, Nida Ziauddeen, Dianna Smith, Paul Roderick, Debbie Chase and Nisreen A. Alwan
    Citation: BMC Medicine 2020 18:43

    The Commentary to this article has been published in BMC Medicine 2020 18:59