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  1. Up to 90% of pregnant women experience nausea and vomiting. When prolonged or severe, this is known as hyperemesis gravidarum (HG), which can, in individual cases, be life threatening. In this article the aeti...

    Authors: JK Jueckstock, R Kaestner and I Mylonas
    Citation: BMC Medicine 2010 8:46
  2. Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional regulator of genes regulating oxygen homeostasis. The HIF-1 protein is composed of two HIF-1α and HIF-1β/aryl hydrocarbon receptor nuclear translo...

    Authors: Jean-Philippe Dales, Nathalie Beaufils, Monique Silvy, Christophe Picard, Vanessa Pauly, Vincent Pradel, Christine Formisano-Tréziny, Pascal Bonnier, Sophie Giusiano, Colette Charpin and Jean Gabert
    Citation: BMC Medicine 2010 8:44
  3. Neonatal hypothermia is associated with an increased mortality risk for 28 days. There are few community-based data on specific risk factors for neonatal hypothermia. Estimates of association between neonatal ...

    Authors: Luke C Mullany, Joanne Katz, Subarna K Khatry, Steven C LeClerq, Gary L Darmstadt and James M Tielsch
    Citation: BMC Medicine 2010 8:43
  4. Polycystic ovary syndrome (PCOS) is of clinical and public health importance as it is very common, affecting up to one in five women of reproductive age. It has significant and diverse clinical implications in...

    Authors: H Teede, A Deeks and L Moran
    Citation: BMC Medicine 2010 8:41
  5. Treatment of women for high-grade cervical cancer precursors frequently results in clearance of the associated high-risk human papillomavirus (hrHPV) infection but the role of treatment among women without hrH...

    Authors: Sylvia Taylor, Chunhui Wang, Thomas C Wright, Lynette Denny, Wei-Yann Tsai and Louise Kuhn
    Citation: BMC Medicine 2010 8:40
  6. Dark chocolate and flavanol-rich cocoa products have attracted interest as an alternative treatment option for hypertension, a known risk factor for cardiovascular disease. Previous meta-analyses concluded tha...

    Authors: Karin Ried, Thomas Sullivan, Peter Fakler, Oliver R Frank and Nigel P Stocks
    Citation: BMC Medicine 2010 8:39
  7. Psychological therapies provided in primary care are usually briefer than in secondary care. There has been no recent comprehensive review comparing their effectiveness for common mental health problems. We ai...

    Authors: John Cape, Craig Whittington, Marta Buszewicz, Paul Wallace and Lisa Underwood
    Citation: BMC Medicine 2010 8:38
  8. The potentially serious nature of herpes zoster (HZ) and the long-term complication post-herpetic neuralgia (PHN) are often underestimated. One in four people will contract herpes zoster in their lifetime, wit...

    Authors: Robert W Johnson, Didier Bouhassira, George Kassianos, Alain Leplège, Kenneth E Schmader and Thomas Weinke
    Citation: BMC Medicine 2010 8:37
  9. In a recently published paper, Harvey and Wessely put forward a 'biopsychosocial' explanatory model for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), which is proposed to be applicable to (chron...

    Authors: Michael Maes and Frank NM Twisk
    Citation: BMC Medicine 2010 8:35
  10. Myocardial infarction causes significant mortality and morbidity. Timely diagnosis allows clinicians to risk stratify their patients and select appropriate treatment. Biomarkers have been used to assist with t...

    Authors: Daniel Chan and Leong L Ng
    Citation: BMC Medicine 2010 8:34
  11. In both Europe and the US, resident physician work hour reduction has been a source of controversy within academic medicine. In 2008, the Institute of Medicine (IOM) recommended a reduction in resident physici...

    Authors: Alexander B Blum, Farbod Raiszadeh, Sandra Shea, David Mermin, Peter Lurie, Christopher P Landrigan and Charles A Czeisler
    Citation: BMC Medicine 2010 8:33
  12. The frequency of mental illness amongst adolescents and its potential long-term consequences make it an important topic to research in relation to risk and protective factors. Research on the relationship betw...

    Authors: Catherine Rothon, Phil Edwards, Kamaldeep Bhui, Russell M Viner, Stephanie Taylor and Stephen A Stansfeld
    Citation: BMC Medicine 2010 8:32
  13. Uncomplicated lower urinary tract infections (UTI) are usually treated with antibiotics. However, there is little evidence for alternative therapeutic options.

    Authors: Jutta Bleidorn, Ildikó Gágyor, Michael M Kochen, Karl Wegscheider and Eva Hummers-Pradier
    Citation: BMC Medicine 2010 8:30
  14. Forced expiratory volume in one second (FEV1) is used to diagnose and establish a prognosis in chronic obstructive pulmonary disease (COPD). Using multi-dimensional scores improves this predictive capacity.Two in...

    Authors: Cristóbal Esteban, José M Quintana, Javier Moraza, Myriam Aburto, Urko Aguirre, José I Aguirregomoscorta, Susana Aizpiri, Luis V Basualdo and Alberto Capelastegui
    Citation: BMC Medicine 2010 8:28
  15. Breast cancer studies frequently focus on the role of the tumor microenvironment in the promotion of cancer; however, the influence of the normal breast microenvironment on cancer cells remains relatively unkn...

    Authors: Jodie M Fleming, Tyler C Miller, Mariam Quinones, Zhen Xiao, Xia Xu, Matthew J Meyer, Erika Ginsburg, Timothy D Veenstra and Barbara K Vonderhaar
    Citation: BMC Medicine 2010 8:27
  16. Oncogenic point mutations in KIT or PDGFRA are recognized as the primary events responsible for the pathogenesis of most gastrointestinal stromal tumors (GIST), but additional genomic alterations are frequent and...

    Authors: Mara Silva, Isabel Veiga, Franclim R Ribeiro, Joana Vieira, Carla Pinto, Manuela Pinheiro, Bárbara Mesquita, Catarina Santos, Marta Soares, José Dinis, Lúcio Santos, Paula Lopes, Mariana Afonso, Carlos Lopes and Manuel R Teixeira
    Citation: BMC Medicine 2010 8:26
  17. Radiation therapy has come a long way from treatment planning based on orthogonal radiographs with large margins around tumours. Advances in imaging and radiation planning software have led to three-dimensiona...

    Authors: SA Bhide and CM Nutting
    Citation: BMC Medicine 2010 8:25
  18. Although current electronic methods of scientific publishing offer increased opportunities for publishing all research studies and describing them in sufficient detail, health research literature still suffers...

    Authors: Iveta Simera, David Moher, Allison Hirst, John Hoey, Kenneth F Schulz and Douglas G Altman
    Citation: BMC Medicine 2010 8:24
  19. There are few studies that have investigated temporal trends in risk of recurrent stroke. The aim of this study was to examine temporal trends in hospitalisation for stroke recurrence following incident hospit...

    Authors: James Lewsey, Pardeep S Jhund, Michelle Gillies, Jim WT Chalmers, Adam Redpath, Andrew Briggs, Matthew Walters, Peter Langhorne, Simon Capewell, John JV McMurray and Kate MacIntyre
    Citation: BMC Medicine 2010 8:23
  20. A central element in the current debate about best practice management of non-specific low back pain (NSLBP) is the efficacy of targeted versus generic (non-targeted) treatment. Many clinicians and researchers...

    Authors: Peter Kent, Hanne L Mjøsund and Ditte HD Petersen
    Citation: BMC Medicine 2010 8:22
  21. Appropriate choice and use of prognostic models in clinical practice require the use of good methods for both model development, and for developing prognostic indices and risk groups from the models. In order ...

    Authors: Susan Mallett, Patrick Royston, Rachel Waters, Susan Dutton and Douglas G Altman
    Citation: BMC Medicine 2010 8:21
  22. Amifostine (WR-2721, delivered as Ethyol®) is a phosphorylated aminothiol compound clinically used in addition to cis-platinum to reduce the toxic side effects of therapeutic treatment on normal cells without red...

    Authors: S Dedieu, X Canron, HR Rezvani, M Bouchecareilh, F Mazurier, R Sinisi, M Zanda, M Moenner, A Bikfalvi and S North
    Citation: BMC Medicine 2010 8:19
  23. Acute seizures are common among children admitted to hospitals in resource poor countries. However, there is little data on the burden, causes and outcome of neonatal seizures in sub-Saharan Africa. We determi...

    Authors: Michael Mwaniki, Ali Mathenge, Samson Gwer, Neema Mturi, Evasius Bauni, Charles RJC Newton, James Berkley and Richard Idro
    Citation: BMC Medicine 2010 8:16
  24. The use of placebo interventions outside clinical trials is ethically, professionally and legally controversial. Little is known about the frequency and circumstances of placebo use in clinical practice. Our a...

    Authors: Margrit Fässler, Karin Meissner, Antonius Schneider and Klaus Linde
    Citation: BMC Medicine 2010 8:15
  25. Melanoma incidence is on the rise and advanced melanoma carries an extremely poor prognosis. Treatment options, including chemotherapy and immunotherapy, are limited and offer low response rates and transient ...

    Authors: Yixiang Wang, Soroosh Radfar, Suhu Liu, Adam I Riker and Hung T Khong
    Citation: BMC Medicine 2010 8:14
  26. There are currently no accurate serum markers for detecting early risk of colorectal cancer (CRC). We therefore developed a non-targeted metabolomics technology to analyse the serum of pre-treatment CRC patien...

    Authors: Shawn A Ritchie, Pearson WK Ahiahonu, Dushmanthi Jayasinghe, Doug Heath, Jun Liu, Yingshen Lu, Wei Jin, Amir Kavianpour, Yasuyo Yamazaki, Amin M Khan, Mohammad Hossain, Khine Khine Su-Myat, Paul L Wood, Kevin Krenitsky, Ichiro Takemasa, Masakazu Miyake…
    Citation: BMC Medicine 2010 8:13
  27. DNA-methyltransferase (DNMT)-3A plays an important role in the development of embryogenesis and the generation of aberrant methylation in carcinogenesis. The aim of this study was to investigate the role of a ...

    Authors: Hong Fan, Dongsheng Liu, Xuemei Qiu, Fengchang Qiao, Qingxiang Wu, Xianwei Su, Feng Zhang, Yunwei Song, Zhujiang Zhao and Wei Xie
    Citation: BMC Medicine 2010 8:12
  28. Although poorly described in the literature, the practice of early (short-interval) rescreen after a negative screening mammogram is controversial due to its financial and psychological burden and because it i...

    Authors: Alessandra Ravaioli, Flavia Foca, Americo Colamartini, Fabio Falcini, Carlo Naldoni, Alba C Finarelli, Priscilla Sassoli de Bianchi and Lauro Bucchi
    Citation: BMC Medicine 2010 8:11
  29. Low back pain is a highly prevalent and disabling condition worldwide. Clinical guidelines for the management of patients with acute low back pain recommend first-line treatment consisting of advice, reassuran...

    Authors: Luciana AC Machado, Chris G Maher, Rob D Herbert, Helen Clare and James H McAuley
    Citation: BMC Medicine 2010 8:10
  30. Chest pain raises concern for the possibility of coronary heart disease. Scoring methods have been developed to identify coronary heart disease in emergency settings, but not in primary care.

    Authors: Baris Gencer, Paul Vaucher, Lilli Herzig, François Verdon, Christiane Ruffieux, Stefan Bösner, Bernard Burnand, Thomas Bischoff, Norbert Donner-Banzhoff and Bernard Favrat
    Citation: BMC Medicine 2010 8:9
  31. Almost five decades ago, governments around the world adopted the 1961 Single Convention on Narcotic Drugs which, in addition to addressing the control of illicit narcotics, obligated countries to work towards...

    Authors: Diederik Lohman, Rebecca Schleifer and Joseph J Amon
    Citation: BMC Medicine 2010 8:8
  32. Diagnosis-based risk adjustment is becoming an important issue globally as a result of its implications for payment, high-risk predictive modelling and provider performance assessment. The Taiwanese National H...

    Authors: Hsien-Yen Chang and Jonathan P Weiner
    Citation: BMC Medicine 2010 8:7
  33. Inflammatory cytokines play a crucial role in coronary artery disease (CAD). We investigated the association between 48 coding and three non-coding single nucleotide polymorphisms (SNPs) from 35 inflammatory g...

    Authors: Benjamin D Brown, Jérémie Nsengimana, Jennifer H Barrett, Richard A Lawrence, Lori Steiner, Suzanne Cheng, D Timothy Bishop, Nilesh J Samani, Stephen G Ball, Anthony J Balmforth and Alistair S Hall
    Citation: BMC Medicine 2010 8:5
  34. The U.S. Food and Drug Administration (FDA) recently linked antiepileptic drug (AED) exposure to suicide-related behaviors based on meta-analysis of randomized clinical trials. We examined the relationship bet...

    Authors: Anne C VanCott, Joyce A Cramer, Laurel A Copeland, John E Zeber, Michael A Steinman, Jeffrey J Dersh, Mark E Glickman, Eric M Mortensen, Megan E Amuan and Mary Jo Pugh
    Citation: BMC Medicine 2010 8:4
  35. Platinum-based combinations are the standard second-line treatment for platinum-sensitive ovarian cancer (OC). This randomized phase II study was undertaken in order to compare the combination of carboplatin a...

    Authors: Dimitrios Bafaloukos, Helena Linardou, Gerasimos Aravantinos, Christos Papadimitriou, Aristotelis Bamias, George Fountzilas, Haralabos P Kalofonos, Paris Kosmidis, Eleni Timotheadou, Thomas Makatsoris, Epaminondas Samantas, Evangelos Briasoulis, Christos Christodoulou, Pavlos Papakostas, Dimitrios Pectasides and Athanasios M Dimopoulos
    Citation: BMC Medicine 2010 8:3
  36. Insulin-like growth factor-1 (IGF-I) signalling is important for cancer initiation and progression. Given the emerging evidence for the role of the stroma in these processes, we aimed to characterize the effec...

    Authors: Michal Rajski, Rosanna Zanetti-Dällenbach, Brigitte Vogel, Richard Herrmann, Christoph Rochlitz and Martin Buess
    Citation: BMC Medicine 2010 8:1
  37. Directly observed therapy (DOT) remains the cornerstone of the global tuberculosis (TB) control strategy. Tanzania, one of the 22 high-burden countries regarding TB, changed the first-line treatment regimen to...

    Authors: Saidi Egwaga, Abdallah Mkopi, Nyagosya Range, Vera Haag-Arbenz, Amuri Baraka, Penny Grewal, Frank Cobelens, Hassan Mshinda, Fred Lwilla and Frank van Leth
    Citation: BMC Medicine 2009 7:80
  38. It is becoming increasingly apparent that cancer drug therapies can only reach their full potential through appropriate patient selection. Matching drugs and cancer patients has proven to be a complex challeng...

    Authors: Cyril Benes and Jeff Settleman
    Citation: BMC Medicine 2009 7:78