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  1. A number of publications have reported the use of microarray technology to identify gene expression signatures to infer mechanisms and pathways associated with systemic lupus erythematosus (SLE) in human perip...

    Authors: Dhivya Arasappan, Weida Tong, Padmaja Mummaneni, Hong Fang and Shashi Amur
    Citation: BMC Medicine 2011 9:65
  2. Soft tissue sarcomas of childhood are a group of heterogeneous tumors thought to be derived from mesenchymal stem cells. Surgical resection is effective only in about 50% of cases and resistance to conventiona...

    Authors: Roberta Ciarapica, Lucio Miele, Antonio Giordano, Franco Locatelli and Rossella Rota
    Citation: BMC Medicine 2011 9:63
  3. The functional role of oxidative stress in cancer pathogenesis has long been a hotly debated topic. A study published this month in BMC Cancer by Goh et al., directly addresses this issue by using a molecular gen...

    Authors: Federica Sotgia, Ubaldo E Martinez-Outschoorn and Michael P Lisanti
    Citation: BMC Medicine 2011 9:62
  4. Early infant diagnosis (EID) of HIV-1 infection confers substantial benefits to HIV-infected and HIV-uninfected infants, to their families, and to programs providing prevention of mother-to-child transmission ...

    Authors: Andrea L Ciaranello, Ji-Eun Park, Lynn Ramirez-Avila, Kenneth A Freedberg, Rochelle P Walensky and Valeriane Leroy
    Citation: BMC Medicine 2011 9:59
  5. Despite more than a decade of research on hospitalists and their performance, disagreement still exists regarding whether and how hospital-based physicians improve the quality of inpatient care delivery. This ...

    Authors: Heather L White and Richard H Glazier
    Citation: BMC Medicine 2011 9:58
  6. Urinary tract infections (UTI) are common among the oldest old and may lead to a few days of illness, delirium or even to death. We studied the incidence and predictive factors of UTI among the oldest old in t...

    Authors: Monique AA Caljouw, Wendy PJ den Elzen, Herman JM Cools and Jacobijn Gussekloo
    Citation: BMC Medicine 2011 9:57
  7. Physicians fear missing cases of pneumonia and treat many patients with signs of respiratory infection unnecessarily with antibiotics. This is an avoidable cause for the increasing worldwide problem of antibio...

    Authors: Johann Steurer, Ulrike Held, Anne Spaar, Birke Bausch, Marco Zoller, Roger Hunziker and Lucas M Bachmann
    Citation: BMC Medicine 2011 9:56
  8. The World Health Organization (WHO) recommends that the cost-effectiveness (CE) of introducing new vaccines be considered before such a programme is implemented. However, in low- and middle-income countries (L...

    Authors: Raymond Hutubessy, Ana Maria Henao, Pem Namgyal, Vasee Moorthy and Joachim Hombach
    Citation: BMC Medicine 2011 9:55
  9. The World Health Organization (WHO) recommends that the cost effectiveness of introducing human papillomavirus (HPV) vaccination is considered before such a strategy is implemented. However, developing countri...

    Authors: Mark Jit, Nadia Demarteau, Elamin Elbasha, Gary Ginsberg, Jane Kim, Naiyana Praditsitthikorn, Edina Sinanovic and Raymond Hutubessy
    Citation: BMC Medicine 2011 9:54
  10. Several decision support tools have been developed to aid policymaking regarding the adoption of pneumococcal conjugate vaccine (PCV) into national pediatric immunization programs. The lack of critical apprais...

    Authors: Nathorn Chaiyakunapruk, Ratchadaporn Somkrua, Raymond Hutubessy, Ana Maria Henao, Joachim Hombach, Alessia Melegaro, John W Edmunds and Philippe Beutels
    Citation: BMC Medicine 2011 9:53
  11. In recent years, clinical trials with stem cells have taken the emerging field in many new directions. While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for t...

    Authors: Alan Trounson, Rahul G Thakar, Geoff Lomax and Don Gibbons
    Citation: BMC Medicine 2011 9:52
  12. Changing clinicians' behaviour is recognised as a major challenge. It is clear that behaviour change not only depends on demonstrating the proven effectiveness of clinical interventions; contextual and occupat...

    Authors: Tom Sanders, Nadine E Foster and Bie Nio Ong
    Citation: BMC Medicine 2011 9:49
  13. Metabolic syndrome (MetS) is a complex disorder defined by a cluster of interconnected factors that increase the risk of cardiovascular atherosclerotic diseases and diabetes mellitus type 2. Currently, several...

    Authors: Eva Kassi, Panagiota Pervanidou, Gregory Kaltsas and George Chrousos
    Citation: BMC Medicine 2011 9:48
  14. The 2010 Global Burden of Disease Study estimates the premature mortality and disability of all major diseases and injuries. In addition it aims to quantify the risk that diseases and other factors play in the...

    Authors: Fiona J Charlson, Nicholas JC Stapelberg, Amanda J Baxter and Harvey A Whiteford
    Citation: BMC Medicine 2011 9:47
  15. Electronic health record (EHR) implementation is currently underway in Canada, as in many other countries. These ambitious projects involve many stakeholders with unique perceptions of the implementation proce...

    Authors: Carrie Anna McGinn, Sonya Grenier, Julie Duplantie, Nicola Shaw, Claude Sicotte, Luc Mathieu, Yvan Leduc, France Légaré and Marie-Pierre Gagnon
    Citation: BMC Medicine 2011 9:46
  16. Viral respiratory infections are common worldwide and range from completely benign disease to life-threatening illness. Symptoms can be unspecific, and an etiologic diagnosis is rarely established because of a...

    Authors: Robin Brittain-Long, Johan Westin, Sigvard Olofsson, Magnus Lindh and Lars-Magnus Andersson
    Citation: BMC Medicine 2011 9:44
  17. Motor impairment in old age is a growing public-health concern, and several different constructs have been used to identify motor impairments in older people. We tested the hypothesis that combinations of moto...

    Authors: Aron S Buchman, Sue E Leurgans, Patricia A Boyle,, Julie A Schneider,, Steven E Arnold and David A Bennett
    Citation: BMC Medicine 2011 9:42
  18. Accumulating evidence suggests that the brain's nitric oxide (NO) signalling system may be involved in the pathophysiology of schizophrenia and could thus constitute a novel treatment target. The study was des...

    Authors: Caroline Wass, Daniel Klamer, Evangelos Katsarogiannis, Erik Pålsson, Lennart Svensson, Kim Fejgin, Inga-Britt Bogren, Jörgen A Engel and Birgitta Rembeck
    Citation: BMC Medicine 2011 9:40
  19. Prescription of non-steroidal anti-inflammatory drugs (NSAIDs) should be based on the assessment of both gastrointestinal (GI) and cardiovascular (CV) risk for the individual patient. We aimed to assess the GI...

    Authors: Angel Lanas, Guillermo Garcia-Tell, Beatriz Armada and Angel Oteo-Alvaro
    Citation: BMC Medicine 2011 9:38
  20. Some areas of Africa are witnessing a malaria transition, in part due to escalated international donor support and intervention coverage. Areas where declining malaria rates have been observed are largely char...

    Authors: Emelda A Okiro, David Bitira, Gladys Mbabazi, Arthur Mpimbaza, Victor A Alegana, Ambrose O Talisuna and Robert W Snow
    Citation: BMC Medicine 2011 9:37
  21. The addition of Rituximab (R) to standard chemotherapy (C) has been reported to improve the end of treatment outcome in patients affected by CD-20 positive malignant lymphomas (CD20+ ML). Nevertheless, given t...

    Authors: Simone Lanini, Aoife C Molloy, Paul E Fine, Archibald G Prentice, Giuseppe Ippolito and Christopher C Kibbler
    Citation: BMC Medicine 2011 9:36
  22. The rapidly increasing number of activity-induced musculoskeletal injuries among adolescents and young adults is currently a true public health burden. The objective of this study was to investigate whether a ...

    Authors: Jari Parkkari, Henri Taanila, Jaana Suni, Ville M Mattila, Olli Ohrankämmen, Petteri Vuorinen, Pekka Kannus and Harri Pihlajamäki
    Citation: BMC Medicine 2011 9:35
  23. Biguanides have been developed for the treatment of hyperglycemia and type 2 diabetes. Recently, metformin, the most widely prescribed biguanide, has emerged as a potential anticancer agent. Epidemiological, p...

    Authors: Ryan JO Dowling, Pamela J Goodwin and Vuk Stambolic
    Citation: BMC Medicine 2011 9:33
  24. A study conducted by Lai and colleagues, published this week in BMC Medicine, suggests that more guidance might be required for interpreting systematic review (SR) results. In the study by Lai and colleagues, pos...

    Authors: Andrea C Tricco, Sharon E Straus and David Moher
    Citation: BMC Medicine 2011 9:31
  25. Health professions education programs use simulation for teaching and maintaining clinical procedural skills. Simulated learning activities are also becoming useful methods of instruction for interprofessional...

    Authors: Chris Kenaszchuk, Kathleen MacMillan, Mary van Soeren and Scott Reeves
    Citation: BMC Medicine 2011 9:29
  26. Despite our substantial understanding of molecular mechanisms and gene mutations involved in cancer, the technical approaches for diagnosis and prognosis of cancer are limited. In routine clinical diagnosis of...

    Authors: Callinice D Capo-chichi, Kathy Q Cai, Fiona Simpkins, Parvin Ganjei-Azar, Andrew K Godwin and Xiang-Xi Xu
    Citation: BMC Medicine 2011 9:28
  27. Chronic fatigue syndrome (CFS) is a complex multifactorial disorder. This paper reports the prevalence of chronic fatigue (CF) and CFS in an ethnically diverse population sample and tests whether prevalence va...

    Authors: Kamaldeep S Bhui, Sokratis Dinos, Deborah Ashby, James Nazroo, Simon Wessely and Peter D White
    Citation: BMC Medicine 2011 9:26
  28. Recent studies have shown that adipose tissue is an active endocrine and paracrine organ secreting several mediators called adipokines. Adipokines include hormones, inflammatory cytokines and other proteins. I...

    Authors: Nele Maenhaut and Johan Van de Voorde
    Citation: BMC Medicine 2011 9:25
  29. 'Gut health' is a term increasingly used in the medical literature and by the food industry. It covers multiple positive aspects of the gastrointestinal (GI) tract, such as the effective digestion and absorpti...

    Authors: Stephan C Bischoff
    Citation: BMC Medicine 2011 9:24
  30. Celiac disease (CD) is an autoimmune enteropathy triggered by the ingestion of gluten. Gluten-sensitive individuals (GS) cannot tolerate gluten and may develop gastrointestinal symptoms similar to those in CD,...

    Authors: Anna Sapone, Karen M Lammers, Vincenzo Casolaro, Marcella Cammarota, Maria Teresa Giuliano, Mario De Rosa, Rosita Stefanile, Giuseppe Mazzarella, Carlo Tolone, Maria Itria Russo, Pasquale Esposito, Franca Ferraraccio, Maria Cartenì, Gabriele Riegler, Laura de Magistris and Alessio Fasano
    Citation: BMC Medicine 2011 9:23
  31. Several studies have reported hypoperfusion of the brain parenchyma in multiple sclerosis (MS) patients. We hypothesized a possible relationship between abnormal perfusion in MS and hampered venous outflow at ...

    Authors: Paolo Zamboni, Erica Menegatti, Bianca Weinstock-Guttman, Michael G Dwyer, Claudiu V Schirda, Anna M Malagoni, David Hojnacki, Cheryl Kennedy, Ellen Carl, Niels Bergsland, Christopher Magnano, Ilaria Bartolomei, Fabrizio Salvi and Robert Zivadinov
    Citation: BMC Medicine 2011 9:22
  32. Cerebral microdialysis (MD) is used to monitor local brain chemistry of patients with traumatic brain injury (TBI). Despite an extensive literature on cerebral MD in the clinical setting, it remains unclear ho...

    Authors: David W Nelson, Björn Thornquist, Robert M MacCallum, Harriet Nyström, Anders Holst, Anders Rudehill, Michael Wanecek, Bo-Michael Bellander and Eddie Weitzberg
    Citation: BMC Medicine 2011 9:21
  33. Truth claims in the medical literature rely heavily on statistical significance testing. Unfortunately, most physicians misunderstand the underlying probabilistic logic of significance tests and consequently o...

    Authors: M Brandon Westover, Kenneth D Westover and Matt T Bianchi
    Citation: BMC Medicine 2011 9:20
  34. Mucin 4 (MUC4) plays an important role in protecting and lubricating the epithelial surface of reproductive tracts, but its role in the pathogenesis of endometriosis is largely unknown.

    Authors: Cherry Yin-Yi Chang, Hui-Wen Chang, Chih-Mei Chen, Chia-Ying Lin, Chih-Ping Chen, Chih-Ho Lai, Wei-Yong Lin, Hsing-Ping Liu, Jim Jinn-Chyuan Sheu and Fuu-Jen Tsai
    Citation: BMC Medicine 2011 9:19
  35. Complex neurodevelopmental disorders may be characterized by subtle brain function signatures early in life before behavioral symptoms are apparent. Such endophenotypes may be measurable biomarkers for later c...

    Authors: William Bosl, Adrienne Tierney, Helen Tager-Flusberg and Charles Nelson
    Citation: BMC Medicine 2011 9:18
  36. Until fairly recently, medical publications have been handicapped by being restricted to non-electronic formats, effectively preventing the dissemination of complex audiovisual and three-dimensional data. Howe...

    Authors: Alexander Ziegler, Daniel Mietchen, Cornelius Faber, Wolfram von Hausen, Christoph Schöbel, Markus Sellerer and Andreas Ziegler
    Citation: BMC Medicine 2011 9:17
  37. Differences in sex hormone levels among populations might contribute to the variation in breast cancer incidence across countries. Previous studies have shown higher breast cancer incidence and mortality among...

    Authors: Motoki Iwasaki, Yoshio Kasuga, Shiro Yokoyama, Hiroshi Onuma, Hideki Nishimura, Ritsu Kusama, Gerson Shigeaki Hamada, Ines Nobuko Nishimoto, Maria do Socorro Maciel, Juvenal Motola Jr, Fábio Martins Laginha, Roberto Anzai and Shoichiro Tsugane
    Citation: BMC Medicine 2011 9:16