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  2. Fascin-1 is an actin-bundling protein expressed in many human carcinomas, although absent from most normal epithelia. Fascin-1 promotes filopodia formation, migration and invasion in carcinoma cells; in mouse ...

    Authors: Vanessa Y Tan, Sarah J Lewis, Josephine C Adams and Richard M Martin
    Citation: BMC Medicine 2013 11:52
    Content type: Research article Published on:

  3. The majority of patients presenting with mild head trauma will have no intracranial pathology and can be safely discharged home. It is estimated that 10% to 15% of these patients will have clinically significa...

    Authors: Carolyn M Benson and G Bryan Young
    Citation: BMC Medicine 2013 11:51
    Content type: Commentary Published on:

  4. The management of minimal, mild and moderate head injuries is still controversial. In 2000, the Scandinavian Neurotrauma Committee (SNC) presented evidence-based guidelines for initial management of these inju...

    Authors: Johan Undén, Tor Ingebrigtsen and Bertil Romner
    Citation: BMC Medicine 2013 11:50
    Content type: Guideline Published on:

  6. Comprehensive geriatric assessment for older patients admitted to dedicated wards has proven to be beneficial, but the impact of comprehensive geriatric assessment delivered by mobile inpatient geriatric consu...

    Authors: Mieke Deschodt, Johan Flamaing, Patrick Haentjens, Steven Boonen and Koen Milisen
    Citation: BMC Medicine 2013 11:48
    Content type: Research article Published on:

  7. Data on the combined effect of lifestyles on mortality in older people have generally been collected from highly selected populations and have been limited to traditional health behaviors. In this study, we ex...

    Authors: David Martínez-Gómez, Pilar Guallar-Castillón, Luz M León-Muñoz, Esther López-García and Fernando Rodríguez-Artalejo
    Citation: BMC Medicine 2013 11:47
    Content type: Research article Published on:

  8. A recent study using a rat model found significant differences at the time of diabetes onset in the bacterial communities responsible for type 1 diabetes modulation. We hypothesized that type 1 diabetes in hum...

    Authors: Mora Murri, Isabel Leiva, Juan Miguel Gomez-Zumaquero, Francisco J Tinahones, Fernando Cardona, Federico Soriguer and María Isabel Queipo-Ortuño
    Citation: BMC Medicine 2013 11:46
    Content type: Research article Published on:

  9. To investigate differences in the performance of the Finnish Diabetes Risk Score (FINDRISC) as a screening tool for glucose abnormalities after shifting from glucose-based diagnostic criteria to the proposed n...

    Authors: Bernardo Costa, Francisco Barrio, Josep L Piñol, Joan J Cabré, Xavier Mundet, Ramon Sagarra, Jordi Salas-Salvadó and Oriol Solà-Morales
    Citation: BMC Medicine 2013 11:45
    Content type: Research article Published on:

  10. The hypothalamic-pituitary-adrenal (HPA) axis, and in particular cortisol, has been reported to be involved in obesity-associated metabolic disturbances in adults and in selected populations of adolescents. Th...

    Authors: Flavia Prodam, Roberta Ricotti, Valentina Agarla, Silvia Parlamento, Giulia Genoni, Caterina Balossini, Gillian Elisabeth Walker, Gianluca Aimaretti, Gianni Bona and Simonetta Bellone
    Citation: BMC Medicine 2013 11:44
    Content type: Research article Published on:

  11. Management of type 2 diabetes with metformin often does not provide adequate glycemic control, thereby necessitating add-on treatment. In a 24-week clinical trial, dapagliflozin, an investigational sodium gluc...

    Authors: Clifford J Bailey, Jorge L Gross, Delphine Hennicken, Nayyar Iqbal, Traci A Mansfield and James F List
    Citation: BMC Medicine 2013 11:43
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Medicine 2013 11:193

  12. Pregnant women consume caffeine daily. The aim of this study was to examine the association between maternal caffeine intake from different sources and (a) gestational length, particularly the risk for spontan...

    Authors: Verena Sengpiel, Elisabeth Elind, Jonas Bacelis, Staffan Nilsson, Jakob Grove, Ronny Myhre, Margaretha Haugen, Helle Margrete Meltzer, Jan Alexander, Bo Jacobsson and Anne-Lise Brantsæter
    Citation: BMC Medicine 2013 11:42
    Content type: Research article Published on:

  13. Despite the increasing understanding of the mechanisms relating to weight loss and maintenance, there are currently no validated public health interventions that are able to achieve sustained long-term weight ...

    Authors: Katherine Hafekost, David Lawrence, Francis Mitrou, Therese A O'Sullivan and Stephen R Zubrick
    Citation: BMC Medicine 2013 11:41
    Content type: Opinion Published on:

  15. In recent years, medical practice has followed two different paradigms: evidence-based medicine (EBM) and values-based medicine (VBM). There is an urgent need to promote medical education that strengthens the ...

    Authors: Myriam M Altamirano-Bustamante, Nelly F Altamirano-Bustamante, Alberto Lifshitz, Ignacio Mora-Magaña, Adalberto de Hoyos, María Teresa Ávila-Osorio, Silvia Quintana-Vargas, Jorge A Aguirre, Jorge Méndez, Chiharu Murata, Rodrigo Nava-Diosdado, Oscar Martínez-González, Elisa Calleja, Raúl Vargas, Juan Manuel Mejía-Arangure, Araceli Cortez-Domínguez…
    Citation: BMC Medicine 2013 11:39
    Content type: Research article Published on:

  16. Proximal spinal muscular atrophy (SMA), a neurodegenerative disorder that causes infant mortality, has no effective treatment. Sodium vanadate has shown potential for the treatment of SMA; however, vanadate-in...

    Authors: Huei-Chun Liu, Chen-Hung Ting, Hsin-Lan Wen, Li-Kai Tsai, Hsiu-Mei Hsieh-Li, Hung Li and Sue Lin-Chao
    Citation: BMC Medicine 2013 11:38
    Content type: Research article Published on:

  17. The increasing numbers of patients undergoing total hip arthroplasty (THA) or total knee arthroplasty (TKA), combined with the rapidly growing repertoire of surgical techniques and interventions available have...

    Authors: Mazin S Ibrahim, Muhammad A Khan, Ikram Nizam and Fares S Haddad
    Citation: BMC Medicine 2013 11:37
    Content type: Review Published on:

  21. The adverse renal effects of lithium have long been known, but glomerular insufficiency had been considered an unlikely event until recently, when new studies have raised concern regarding very long-term treat...

    Authors: Alberto Bocchetta, Raffaella Ardau, Paolo Carta, Franca Ligas, Claudia Sardu, Antonello Pani and Maria Del Zompo
    Citation: BMC Medicine 2013 11:33
    Content type: Research article Published on:

  22. There is an increased incidence of major depressive disorder (MDD) in individuals after myocardial infarction (MI), but the pathophysiological processes mediating this association are unclear. Our previous stu...

    Authors: Yiming Wang, Xingde Liu, Dongfeng Zhang, Jianhui Chen, Shuzheng Liu and Michael Berk
    Citation: BMC Medicine 2013 11:32
    Content type: Research article Published on:

  25. Data from epidemiological and animal model studies suggest that nutrition during pregnancy may affect the health status of subsequent generations. These transgenerational effects are now being explained by dis...

    Authors: Adelheid Soubry, Joellen M Schildkraut, Amy Murtha, Frances Wang, Zhiqing Huang, Autumn Bernal, Joanne Kurtzberg, Randy L Jirtle, Susan K Murphy and Cathrine Hoyo
    Citation: BMC Medicine 2013 11:29
    Content type: Research article Published on:

  28. Migraine is a disabling common brain disorder typically characterized by attacks of severe headache and associated with autonomic and neurological symptoms. Its etiology is far from resolved. This review will ...

    Authors: Else Eising, Nicole A Datson, Arn MJM van den Maagdenberg and Michel D Ferrari
    Citation: BMC Medicine 2013 11:26
    Content type: Minireview Published on:

  31. Low- and middle-income countries need to consider economic issues such as cost-effectiveness, affordability and sustainability before introducing a program for human papillomavirus (HPV) vaccination. However, ...

    Authors: Mark Jit, Carol Levin, Marc Brisson, Ann Levin, Stephen Resch, Johannes Berkhof, Jane Kim and Raymond Hutubessy
    Citation: BMC Medicine 2013 11:23
    Content type: Correspondence Published on:

  33. There is growing interest in realist synthesis as an alternative systematic review method. This approach offers the potential to expand the knowledge base in policy-relevant areas -for example, by explaining t...

    Authors: Geoff Wong, Trish Greenhalgh, Gill Westhorp, Jeanette Buckingham and Ray Pawson
    Citation: BMC Medicine 2013 11:21
    Content type: Guideline Published on:

  34. Meta-narrative review is one of an emerging menu of new approaches to qualitative and mixed-method systematic review. A meta-narrative review seeks to illuminate a heterogeneous topic area by highlighting the ...

    Authors: Geoff Wong, Trish Greenhalgh, Gill Westhorp, Jeanette Buckingham and Ray Pawson
    Citation: BMC Medicine 2013 11:20
    Content type: Guideline Published on:

  35. In a study by Cruse et al. published in BMC Medicine, patients with severe brain damage who were in the Vegetative or Minimally Conscious States (VS or MCS, respectively) from traumatic and nontraumatic etiologie...

    Authors: Mithu Sen and G Bryan Young
    Citation: BMC Medicine 2013 11:19
    Content type: Commentary Published on:

  36. The Vegetative and Minimally Conscious States (VS; MCS) are characterized by absent or highly disordered signs of awareness alongside preserved sleep-wake cycles. According to international diagnostic guidelin...

    Authors: Damian Cruse, Aurore Thibaut, Athena Demertzi, Julia C Nantes, Marie-Aurélie Bruno, Olivia Gosseries, Audrey Vanhaudenhuyse, Tristan A Bekinschtein, Adrian M Owen and Steven Laureys
    Citation: BMC Medicine 2013 11:18
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Medicine 2018 16:134

  37. Methotrexate (MTX) is the central drug in the management of rheumatoid arthritis (RA) and other immune mediated inflammatory diseases. It is widely used either in monotherapy or in association with other synth...

    Authors: Vasco Crispim Romão, Helena Canhão and João Eurico Fonseca
    Citation: BMC Medicine 2013 11:17
    Content type: Review Published on:

  38. Cigarette smoking is one of the most important causes of morbidity and mortality in the general population, and is a well-recognized risk factor for a variety of serious clinical conditions, including cardiova...

    Authors: Nicola Petrosillo and Stefania Cicalini
    Citation: BMC Medicine 2013 11:16
    Content type: Commentary Published on:

  39. Smoking is common in people infected with HIV but cessation support is not a routine part of clinical care. The aim was to assess whether smoking is a risk factor for pneumonia in people with HIV and whether s...

    Authors: Preeti De, Amanda Farley, Nicola Lindson and Paul Aveyard
    Citation: BMC Medicine 2013 11:15
    Content type: Research article Published on:

  40. As a result of increasing life expectancies, continuing physical careers, lifestyles into later life and rising obesity levels, the number of younger patients presenting with osteoarthritis (OA) of the knee is...

    Authors: Paul M Sutton and Edward S Holloway
    Citation: BMC Medicine 2013 11:14
    Content type: Opinion Published on:

  41. Bladder cancer is the commonest malignancy of the urinary tract. In this review, we look at the latest developments in the diagnosis and management of this condition. Cystoscopy and urine cytology are the most...

    Authors: Grace Cheung, Arun Sahai, Michele Billia, Prokar Dasgupta and Muhammad S Khan
    Citation: BMC Medicine 2013 11:13
    Content type: Review Published on:

  42. Ineffective risk stratification can delay diagnosis of serious disease in patients with hematuria. We applied a systems biology approach to analyze clinical, demographic and biomarker measurements (n = 29) col...

    Authors: Frank Emmert-Streib, Funso Abogunrin, Ricardo de Matos Simoes, Brian Duggan, Mark W Ruddock, Cherith N Reid, Owen Roddy, Lisa White, Hugh F O'Kane, Declan O'Rourke, Neil H Anderson, Thiagarajan Nambirajan and Kate E Williamson
    Citation: BMC Medicine 2013 11:12
    Content type: Research article Published on:

  44. Diagnosing serious infections in children is challenging, because of the low incidence of such infections and their non-specific presentation early in the course of illness. Prediction rules are promoted as a ...

    Authors: Jan Y Verbakel, Ann Van den Bruel, Matthew Thompson, Richard Stevens, Bert Aertgeerts, Rianne Oostenbrink, Henriette A Moll, Marjolein Y Berger, Monica Lakhanpaul, David Mant and Frank Buntinx
    Citation: BMC Medicine 2013 11:10
    Content type: Research article Published on:

  45. Significant advances have been made in understanding the genetic basis of systemic sclerosis (scleroderma) in recent years. Can these discoveries lead to individualized monitoring and treatment? Besides robust...

    Authors: Shervin Assassi, Timothy RDJ Radstake, Maureen D Mayes and Javier Martin
    Citation: BMC Medicine 2013 11:9
    Content type: Minireview Published on:

  47. Risk-stratified treatment recommendations facilitate treatment decision-making that balances patient-specific risks and preferences. It is unclear if and how such recommendations are developed in clinical prac...

    Authors: Tsung Yu, Daniela Vollenweider, Ravi Varadhan, Tianjing Li, Cynthia Boyd and Milo A Puhan
    Citation: BMC Medicine 2013 11:7
    Content type: Research article Published on:

  48. Since 2009, several studies have identified single-nucleotide polymorphisms (SNPs) near the gene encoding for interleukin (IL)-28 (IL28B) that are strongly associated with spontaneous and treatment-induced hepati...

    Authors: María A Jiménez-Sousa, Amanda Fernández-Rodríguez, María Guzmán-Fulgencio, Mónica García-Álvarez and Salvador Resino
    Citation: BMC Medicine 2013 11:6
    Content type: Research article Published on:

  49. Early randomized controlled trials (RCTs) demonstrated the health benefits of omega-3 fatty acids (n-3), whereas recent RCTs were negative. We now address the issue, focusing on the temporal changes having occ...

    Authors: Michel de Lorgeril, Patricia Salen, Pascal Defaye and Mikael Rabaeus
    Citation: BMC Medicine 2013 11:5
    Content type: Opinion Published on:
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