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26 result(s) for 'pain alzheimer's' within BMC Medicine

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  1. Compared to healthy controls, people with Alzheimer’s disease (AD) have been shown to receive less pain medication and report pain less frequently. It is unknown if these findings reflect less perceived pain i...

    Authors: Todd B. Monroe, Stephen J. Gibson, Stephen P. Bruehl, John C. Gore, Mary S. Dietrich, Paul Newhouse, Sebastian Atalla and Ronald L. Cowan

    Citation: BMC Medicine 2016 14:74

    Content type: Research article

    Published on:

  2. High symptom burden is common in long-term care residents with dementia and results in distress and behavioral challenges if undetected. Physicians may have limited time to regularly examine all residents, par...

    Authors: Clare Ellis-Smith, Catherine J. Evans, Anna E. Bone, Lesley A. Henson, Mendwas Dzingina, Pauline M. Kane, Irene J. Higginson and Barbara A. Daveson

    Citation: BMC Medicine 2016 14:38

    Content type: Research article

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  3. Pneumonia in people with dementia has been associated with severe discomfort. We sought to assess the effectiveness of a practice guideline for optimal symptom relief for nursing home residents with dementia a...

    Authors: Tessa van der Maaden, Henrica C. W. de Vet, Wilco P. Achterberg, Froukje Boersma, Jos M. G. A. Schols, David R. Mehr, Francisca Galindo-Garre, Cees M. P. M. Hertogh, Raymond T. C. M. Koopmans and Jenny T. van der Steen

    Citation: BMC Medicine 2016 14:116

    Content type: Research article

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  4. Advancements in phosphodiesterase (PDE)-targeted therapies have shown promise in recent years for treating patients with a variety of autoimmune diseases. This review summarizes the development of PDE4 inhibit...

    Authors: Neal Kumar, Ari M Goldminz, Noori Kim and Alice B Gottlieb

    Citation: BMC Medicine 2013 11:96

    Content type: Review

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  5. The introduction of proton pump inhibitors (PPIs) into clinical practice has revolutionized the management of acid-related diseases. Studies in primary care and emergency settings suggest that PPIs are frequen...

    Authors: Carmelo Scarpignato, Luigi Gatta, Angelo Zullo and Corrado Blandizzi

    Citation: BMC Medicine 2016 14:179

    Content type: Guideline

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  6. We herein evaluate the Spanish population’s trends in health burden by comparing results of two Global Burden of Diseases, Injuries, and Risk Factors Studies (the GBD studies) performed 20 years apart.

    Authors: Josep Maria Haro, Stefanos Tyrovolas, Noe Garin, Cesar Diaz-Torne, Loreto Carmona, Lidia Sanchez-Riera, Fernando Perez-Ruiz and Christopher JL Murray

    Citation: BMC Medicine 2014 12:236

    Content type: Research article

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  7. There are several guidelines addressing the issues around the use of NSAIDs. However, none has specifically addressed the upper versus lower gastrointestinal (GI) risk of COX-2 selective and non-selective comp...

    Authors: Carmelo Scarpignato, Angel Lanas, Corrado Blandizzi, Willem F Lems, Matthias Hermann and Richard H Hunt

    Citation: BMC Medicine 2015 13:55

    Content type: Guideline

    Published on:

  8. It is of importance whether myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a variant of sickness behavior. The latter is induced by acute infections/injury being principally mediated through pr...

    Authors: Gerwyn Morris, George Anderson, Piotr Galecki, Michael Berk and Michael Maes

    Citation: BMC Medicine 2013 11:64

    Content type: Review

    Published on:

  9. Long before Alzheimer’s disease was established as the leading cause of dementia in old age, cerebrovascular lesions were known to cause cognitive deterioration and associated disability. Since the middle of t...

    Authors: Robert Perneczky, Oren Tene, Johannes Attems, Panteleimon Giannakopoulos, M. Arfan Ikram, Antonio Federico, Marie Sarazin and Lefkos T. Middleton

    Citation: BMC Medicine 2016 14:162

    Content type: Opinion

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  10. Hospitalisation is often harmful for people with dementia and results in high societal costs, so avoidance of unnecessary admissions is a global priority. However, no intervention has yet reduced admissions of...

    Authors: Hilary Shepherd, Gill Livingston, Justin Chan and Andrew Sommerlad

    Citation: BMC Medicine 2019 17:130

    Content type: Research article

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  11. Efficacy of statins has been extensively studied, with much less information reported on their unintended effects. Evidence from randomized controlled trials (RCTs) on unintended effects is often insufficient ...

    Authors: Ana Filipa Macedo, Fiona Claire Taylor, Juan P Casas, Alma Adler, David Prieto-Merino and Shah Ebrahim

    Citation: BMC Medicine 2014 12:51

    Content type: Research article

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  12. Current estimates suggest that approximately 75% of people approaching the end-of-life may benefit from palliative care. The growing numbers of older people and increasing prevalence of chronic illness in many...

    Authors: S. N. Etkind, A. E. Bone, B. Gomes, N. Lovell, C. J. Evans, I. J. Higginson and F. E. M. Murtagh

    Citation: BMC Medicine 2017 15:102

    Content type: Research article

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  13. Evidence suggests that amongst people with dementia there is a high prevalence of comorbid medical conditions and related complaints. The presence of dementia may complicate clinical care for other conditions ...

    Authors: Frances Bunn, Anne-Marie Burn, Claire Goodman, Greta Rait, Sam Norton, Louise Robinson, Johan Schoeman and Carol Brayne

    Citation: BMC Medicine 2014 12:192

    Content type: Research article

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  14. The role of the venous system in the pathogenesis of inflammatory neurological/neurodegenerative diseases remains largely unknown and underinvestigated. Aside from cerebral venous infarcts, thromboembolic even...

    Authors: Jonathan S Alexander, Leonard Prouty, Ikuo Tsunoda, Chaitanya Vijay Ganta and Alireza Minagar

    Citation: BMC Medicine 2013 11:219

    Content type: Review

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  15. Depression is the most common psychiatric disorder worldwide. The burden of disease for depression goes beyond functioning and quality of life and extends to somatic health. Depression has been shown to subseq...

    Authors: Brenda WJH Penninx, Yuri Milaneschi, Femke Lamers and Nicole Vogelzangs

    Citation: BMC Medicine 2013 11:129

    Content type: Review

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  16. Our aims were to evaluate critically the evidence from systematic reviews as well as narrative reviews of the effects of melatonin (MLT) on health and to identify the potential mechanisms of action involved.

    Authors: Pawel P. Posadzki, Ram Bajpai, Bhone Myint Kyaw, Nicola J. Roberts, Amnon Brzezinski, George I. Christopoulos, Ushashree Divakar, Shweta Bajpai, Michael Soljak, Gerard Dunleavy, Krister Jarbrink, Ei Ei Khaing Nang, Chee Kiong Soh and Josip Car

    Citation: BMC Medicine 2018 16:18

    Content type: Research article

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  17. The forthcoming post-Millennium Development Goals era will bring about new challenges in global health. Low- and middle-income countries will have to contend with a dual burden of infectious and non-communicab...

    Authors: Alan D Lopez, Thomas N Williams, Adeera Levin, Marcello Tonelli, Jasvinder A Singh, Peter GJ Burney, Jürgen Rehm, Nora D Volkow, George Koob and Cleusa P Ferri

    Citation: BMC Medicine 2014 12:200

    Content type: Forum

    Published on:

  18. Incontinence constitutes a major health problem affecting millions of people worldwide. The present study aims to assess cure rates from treating urinary (UI) or fecal incontinence (FI) and the number of peopl...

    Authors: Rob Riemsma, Suzanne Hagen, Ruth Kirschner-Hermanns, Christine Norton, Helle Wijk, Karl-Erik Andersson, Christopher Chapple, Julian Spinks, Adrian Wagg, Edward Hutt, Kate Misso, Sohan Deshpande, Jos Kleijnen and Ian Milsom

    Citation: BMC Medicine 2017 15:63

    Content type: Research article

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  19. It is of considerable translational importance whether depression is a form or a consequence of sickness behavior. Sickness behavior is a behavioral complex induced by infections and immune trauma and mediated...

    Authors: Michael Maes, Michael Berk, Lisa Goehler, Cai Song, George Anderson, Piotr Gałecki and Brian Leonard

    Citation: BMC Medicine 2012 10:66

    Content type: Review

    Published on:

  20. There is no criterion reference for assessing healthy ageing and this creates difficulties when conducting and comparing research on ageing across studies. A cardinal feature of ageing is loss of function whic...

    Authors: Jose Lara, Rachel Cooper, Jack Nissan, Annie T Ginty, Kay-Tee Khaw, Ian J Deary, Janet M Lord, Diana Kuh and John C Mathers

    Citation: BMC Medicine 2015 13:222

    Content type: Opinion

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  21. Cognitive impairment of various kinds is common in older people admitted to hospital, but previous research has usually focused on single conditions in highly-selected groups and has rarely examined associatio...

    Authors: Emma L. Reynish, Simona M. Hapca, Nicosha De Souza, Vera Cvoro, Peter T. Donnan and Bruce Guthrie

    Citation: BMC Medicine 2017 15:140

    Content type: Research article

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  22. Neuropsychiatric symptoms affect nearly half of the patients with systemic lupus erythematosus; however, the effect on disease severity, quality of life, and prognosis is tremendous. Symptoms of neuropsychiatr...

    Authors: Shaye Kivity, Nancy Agmon-Levin, Gisele Zandman-Goddard, Joab Chapman and Yehuda Shoenfeld

    Citation: BMC Medicine 2015 13:43

    Content type: Review

    Published on:

  23. What does the future of medicine hold? We asked six researchers to share their most ambitious and optimistic views of the future, grounded in the present but looking out a decade or more from now to consider w...

    Authors: Paul Wicks, Matthew Hotopf, Vaibhav A. Narayan, Ethan Basch, James Weatherall and Muir Gray

    Citation: BMC Medicine 2016 14:176

    Content type: Forum

    Published on:

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