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  1. Hashimoto’s thyroiditis (HT) is an organ-specific autoimmune disease characterized by lymphocyte infiltration that destroys thyrocyte cells. The aim of the present study was to elucidate the role and mechanism...

    Authors: Genpeng Li, Linye He, Jing Huang, Jiaye Liu, Wenjie Chen, Jinjing Zhong, Tao Wei, Zhihui Li, Jingqiang Zhu and Jianyong Lei
    Citation: BMC Medicine 2023 21:206
    Content type: Research article Published on:

  2. While cognitive impairment after stroke is common, cognitive trends before stroke are poorly understood, especially among the Chinese population who have a relatively high stroke burden. We aimed to model the ...

    Authors: Jianian Hua, Jianye Dong, Guo-Chong Chen and Yueping Shen
    Citation: BMC Medicine 2023 21:204
    Content type: Research article Published on:

  3. Norway is a high-income nation with universal tax-financed health care and among the highest per person health spending in the world. This study estimates Norwegian health expenditures by health condition, age...

    Authors: Jonas Minet Kinge, Joseph L. Dieleman, Øystein Karlstad, Ann Kristin Knudsen, Søren Toksvig Klitkou, Simon I. Hay, Theo Vos, Christopher J. L. Murray and Stein Emil Vollset
    Citation: BMC Medicine 2023 21:201
    Content type: Research article Published on:

    The Comment to this article has been published in BMC Global and Public Health 2023 1:23

  5. Contact sports athletes and military personnel who suffered a repetitive mild traumatic brain injury (rmTBI) are at high risk of neurodegenerative diseases such as advanced dementia and chronic traumatic encep...

    Authors: Chaonan Zhang, Cheng Wei, Xingqi Huang, Changxin Hou, Chuan Liu, Shu Zhang, Zilong Zhao, Yafan Liu, Ruiguang Zhang, Lei Zhou, Ying Li, Xubo Yuan and Jianning Zhang
    Citation: BMC Medicine 2023 21:199
    Content type: Research article Published on:

  6. Determining the grade and molecular marker status of intramedullary gliomas is important for assessing treatment outcomes and prognosis. Invasive biopsy for pathology usually carries a high risk of tissue dama...

    Authors: Chao Ma, Liyang Wang, Dengpan Song, Chuntian Gao, Linkai Jing, Yang Lu, Dongkang Liu, Weitao Man, Kaiyuan Yang, Zhe Meng, Huifang Zhang, Ping Xue, Yupeng Zhang, Fuyou Guo and Guihuai Wang
    Citation: BMC Medicine 2023 21:198
    Content type: Research article Published on:

  7. Microvascular complications are associated with an overtly increased risk of adverse outcomes in patients with diabetes including coronary microvascular injury which manifested as disruption of adherens juncti...

    Authors: Xuebin Zhang, Yu Duan, Xiao Zhang, Mengyuan Jiang, Wanrong Man, Yan Zhang, Dexi Wu, Jiye Zhang, Xinglong Song, Congye Li, Jie Lin and Dongdong Sun
    Citation: BMC Medicine 2023 21:197
    Content type: Research article Published on:

  8. Systematic reviews and meta-analyses of randomized clinical trials (RCTs) have reported the benefits of ketogenic diets (KD) in various participants such as patients with epilepsy and adults with overweight or...

    Authors: Chanthawat Patikorn, Pantakarn Saidoung, Tuan Pham, Pochamana Phisalprapa, Yeong Yeh Lee, Krista A. Varady, Sajesh K. Veettil and Nathorn Chaiyakunapruk
    Citation: BMC Medicine 2023 21:196
    Content type: Research article Published on:

  9. Endometriosis is recognized as a complex gynecological disorder that can cause severe pain and infertility, affecting 6–10% of all reproductive-aged women. Endometriosis is a condition in which endometrial tis...

    Authors: Yan Li, Hongyan Liu, Shuting Ye, Bumei Zhang, Xiaopei Li, Jiapei Yuan, Yongrui Du, Jianmei Wang and Yang Yang
    Citation: BMC Medicine 2023 21:195
    Content type: Research article Published on:

  10. Removal of tonsils and adenoids is among the most common surgical procedures worldwide. Evidence of increased risk of cancer following such surgery is, however, inconclusive.

    Authors: Jinfeng Liang, Yi Huang, Li Yin, Fatemeh Sadeghi, Yanping Yang, Xue Xiao, Hans-Olov Adami, Weimin Ye, Zhe Zhang and Fang Fang
    Citation: BMC Medicine 2023 21:194
    Content type: Research article Published on:

  11. Immunotherapy has emerged as an efficient therapeutic approach for cancer management. However, stimulation of host immune system against cancer cells often fails to achieve promising clinical outcomes mainly o...

    Authors: Amirhossein Bahreyni, Huitao Liu, Yasir Mohamud, Yuan Chao Xue, Yiyun Michelle Fan, Yizhuo Lyanne Zhang and Honglin Luo
    Citation: BMC Medicine 2023 21:193
    Content type: Research article Published on:

  12. Both low‐carbohydrate (LC) and calorie-restricted (CR) diets have been shown to have metabolic benefits. However, the two regimens have yet to be thoroughly compared. We conducted a 12-week randomized trial to...

    Authors: Jia Sun, Yuting Ruan, Ningning Xu, Peili Wu, Nie Lin, Kun Yuan, Shengli An, Pei Kang, Shu Li, Qiya Huang, Yingzhang, Yuzhong Li, Jialin Su, Wenjun Ma, Bo Chen, Xiuwei Zhang…
    Citation: BMC Medicine 2023 21:192
    Content type: Research article Published on:

  13. Most studies investigating the association between physical activity (PA) and the risk of type 2 diabetes are derived from self-reported questionnaires, with limited evidence using device-based measurements. T...

    Authors: Jirapitcha Boonpor, Solange Parra-Soto, Fanny Petermann-Rocha, Nathan Lynskey, Verónica Cabanas-Sánchez, Naveed Sattar, Jason M. R. Gill, Paul Welsh, Jill P. Pell, Stuart R. Gray, Frederick K. Ho and Carlos Celis-Morales
    Citation: BMC Medicine 2023 21:191
    Content type: Research article Published on:

  14. Type 1 diabetes (T1D) is a CD4+ T cell-driven autoimmune disease characterized by the destruction of insulin-producing pancreatic β-cells by CD8+ T cells. Achieving glycemic targets in T1D remains challenging in ...

    Authors: Jean Van Rampelbergh, Peter Achenbach, Richard David Leslie, Mohammad Alhadj Ali, Colin Dayan, Bart Keymeulen, Katharine R. Owen, Martin Kindermans, Frédéric Parmentier, Vincent Carlier, Roxana R. Ahangarani, Evelien Gebruers, Nicolas Bovy, Luc Vanderelst, Marcelle Van Mechelen, Pierre Vandepapelière…
    Citation: BMC Medicine 2023 21:190
    Content type: Research article Published on:

  15. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multifaceted condition that affects most body systems. There is currently no known diagnostic biomarker; instead, diagnosis is dependent on appl...

    Authors: Rebekah Maksoud, Chandi Magawa, Natalie Eaton-Fitch, Kiran Thapaliya and Sonya Marshall-Gradisnik
    Citation: BMC Medicine 2023 21:189
    Content type: Research article Published on:

  18. The role of autophagy and autophagy-related genes in peripheral arterial disease (PAD) remains unknown and may be of diagnostic and prognostic value. The aim of this study is to investigate the relationship be...

    Authors: Mengjun Dai, Kangbo Li, Mesud Sacirovic, Claudia Zemmrich, Eva Buschmann, Oliver Ritter, Peter Bramlage, Anja Bondke Persson, Ivo Buschmann and Philipp Hillmeister
    Citation: BMC Medicine 2023 21:186
    Content type: Research article Published on:

  19. Chronic kidney disease (CKD) and non-alcoholic fatty liver disease (NAFLD) frequently co-exist. We assess the impact of having NAFLD on adverse clinical outcomes and all-cause mortality for people with CKD.

    Authors: Theresa J. Hydes, Oliver J. Kennedy, Ryan Buchanan, Daniel J. Cuthbertson, Julie Parkes, Simon D. S. Fraser and Paul Roderick
    Citation: BMC Medicine 2023 21:185
    Content type: Research article Published on:

  20. The Emergency Medical Service (EMS) in Germany is increasingly challenged by strongly rising demand. Speculations about a greater utilisation for minor cases have led to intensive media coverage, but empirical...

    Authors: David Herr, Sangeeta Bhatia, Florian Breuer, Stefan Poloczek, Christopher Pommerenke and Janosch Dahmen
    Citation: BMC Medicine 2023 21:184
    Content type: Research article Published on:

  21. The confirmed cases in the current outbreak of Monkeypox are predominantly identified in the networks of men who have sex with men (MSM). The preexisting antibodies may profoundly impact the transmission of mo...

    Authors: Yanmeng Feng, Yifan Zhang, Shengya Liu, Meng Guo, Haojie Huang, Cuiyuan Guo, Wanhai Wang, Wenhong Zhang, Heng Tang and Yanmin Wan
    Citation: BMC Medicine 2023 21:183
    Content type: Research article Published on:

  22. In high-dimensional data (HDD) settings, the number of variables associated with each observation is very large. Prominent examples of HDD in biomedical research include omics data with a large number of varia...

    Authors: Jörg Rahnenführer, Riccardo De Bin, Axel Benner, Federico Ambrogi, Lara Lusa, Anne-Laure Boulesteix, Eugenia Migliavacca, Harald Binder, Stefan Michiels, Willi Sauerbrei and Lisa McShane
    Citation: BMC Medicine 2023 21:182
    Content type: Guideline Published on:

  23. As new, efficacious respiratory syncytial virus (RSV) immunization products reach the market, affordable pricing as well as improved estimation of disease burden and the full potential and cost effectiveness o...

    Authors: Padmini Srikantiah and Keith P. Klugman
    Citation: BMC Medicine 2023 21:177
    Content type: Editorial Published on:

  24. Higher baseline intakes of flavonoid-rich foods and beverages are associated with a lower risk of chronic disease and mortality in observational studies. However, associations between changes in intakes and mo...

    Authors: Nicola P. Bondonno, Yan Lydia Liu, Yan Zheng, Kerry Ivey, Walter C. Willett, Meir J. Stampfer, Eric B. Rimm and Aedín Cassidy
    Citation: BMC Medicine 2023 21:181
    Content type: Research article Published on:

  25. The sensitivity and specificity of minimal residual disease detected by circulating tumor DNA profiling (ctDNA MRD) in lung cancer, with particular attention to the distinction between landmark strategy and su...

    Authors: Ran Zhong, Rui Gao, Wenhai Fu, Caichen Li, Zhenyu Huo, Yuewen Gao, Yi Lu, Feng Li, Fan Ge, Hengjia Tu, Zhixuan You, Jianxing He and Wenhua Liang
    Citation: BMC Medicine 2023 21:180
    Content type: Research article Published on:

  26. Oxidative stress (OS) is a key pathophysiological mechanism in Crohn’s disease (CD). OS-related genes can be affected by environmental factors, intestinal inflammation, gut microbiota, and epigenetic changes. ...

    Authors: Shu Xu, Xiaozhi Li, Shenghong Zhang, Cancan Qi, Zhenhua Zhang, Ruiqi Ma, Liyuan Xiang, Lianmin Chen, Yijun Zhu, Ce Tang, Arno R. Bourgonje, Miaoxin Li, Yao He, Zhirong Zeng, Shixian Hu, Rui Feng…
    Citation: BMC Medicine 2023 21:179
    Content type: Research article Published on:

  27. Early-stage breast cancer patients treated with chemotherapy risk the development of metabolic disease and weight gain, which can result in increased morbidity and reduced quality of life in survivorship. We a...

    Authors: John Walker, Anil Abraham Joy, Larissa J. Vos, Trevor H. Stenson, John R. Mackey, Juan Jovel, Dina Kao, Karen L. Madsen and Gane Ka-Shu Wong
    Citation: BMC Medicine 2023 21:178
    Content type: Research article Published on:

  28. Manuscript preparation and the (re)submission of articles can create a significant workload in academic jobs. In this exploratory analysis, we estimate the time and costs needed to meet the diverse formatting ...

    Authors: Amy Clotworthy, Megan Davies, Timothy J. Cadman, Jessica Bengtsson, Thea O. Andersen, Manik Kadawathagedara, Johan L. Vinther, Tri-Long Nguyen and Tibor V. Varga
    Citation: BMC Medicine 2023 21:172
    Content type: Correspondence Published on:

  29. Childhood obesity is a global health concern and can lead to lifetime cardiometabolic disease. New advances in metabolomics can provide biochemical insights into the early development of obesity, so we aimed t...

    Authors: Sandi M Azab, Meera Shanmuganathan, Russell J de Souza, Zachary Kroezen, Dipika Desai, Natalie C Williams, Katherine M Morrison, Stephanie A Atkinson, Koon K Teo, Meghan B Azad, Elinor Simons, Theo J Moraes, Piush J Mandhane, Stuart E Turvey, Padmaja Subbarao, Philip Britz-McKibbin…
    Citation: BMC Medicine 2023 21:176
    Content type: Research article Published on:

  31. There is insufficient evidence for the ability of vitamin K2 to improve type 2 diabetes mellitus symptoms by regulating gut microbial composition. Herein, we aimed to demonstrate the key role of the gut microb...

    Authors: Yuntao Zhang, Lin Liu, Chunbo Wei, Xuanyang Wang, Ran Li, Xiaoqing Xu, Yingfeng Zhang, Guannan Geng, Keke Dang, Zhu Ming, Xinmiao Tao, Huan Xu, Xuemin Yan, Jia Zhang, Jinxia Hu and Ying Li
    Citation: BMC Medicine 2023 21:174
    Content type: Research article Published on:

  32. Apatinib, a highly selective VEGFR2 inhibitor, significantly improved efficacy versus placebo as a third- and later-line treatment for advanced gastric cancer in phase 2 and 3 trials. This prospective, single-...

    Authors: Jin Li, Shukui Qin, Lu Wen, Junsheng Wang, Wenying Deng, Weijian Guo, Tongfu Jia, Da Jiang, Guifang Zhang, Yifu He, Yi Ba, Haijun Zhong, Lin Wang, Xiaoyan Lin, Jianwei Yang, Jun Zhao…
    Citation: BMC Medicine 2023 21:173
    Content type: Research article Published on:

  34. Both depression and breast cancer (BC) contribute to a substantial global burden of morbidity and mortality among women, and previous studies have observed a potential depression-BC link. We aimed to comprehen...

    Authors: Xueyao Wu, Wenqiang Zhang, Xunying Zhao, Li Zhang, Minghan Xu, Yu Hao, Jinyu Xiao, Ben Zhang, Jiayuan Li, Peter Kraft, Jordan W. Smoller and Xia Jiang
    Citation: BMC Medicine 2023 21:170
    Content type: Research article Published on:

    The Commentary to this article has been published in BMC Medicine 2023 21:203

  35. Chronic musculoskeletal pain has been linked to dementia; however, chronic pain typically occurs in multiple sites; therefore, this study was to investigate whether greater number of chronic pain sites is asso...

    Authors: Jing Tian, Graeme Jones, Xin Lin, Yuan Zhou, Anna King, James Vickers and Feng Pan
    Citation: BMC Medicine 2023 21:169
    Content type: Research article Published on:

  36. In recent years, the downward trajectory of malaria transmission has slowed and, in some places, reversed. New tools are needed to further reduce malaria transmission. One approach that has received recent att...

    Authors: Jackie Cook, Eleanore Sternberg, Carine J. Aoura, Raphael N’Guessan, Immo Kleinschmidt, Alphonsine A. Koffi, Matthew B. Thomas and Serge-Brice Assi
    Citation: BMC Medicine 2023 21:168
    Content type: Research article Published on:

  37. Early iron deficiency (ID) is a common risk factor for poorer neurodevelopment, limiting children’s potential and contributing to global burden. However, it is unclear how early ID alters the substrate of brai...

    Authors: Mengdi Hua, Donglin Shi, Wenwen Xu, Liuyan Zhu, Xiaoxin Hao, Bingquan Zhu, Qiang Shu, Betsy Lozoff, Fengji Geng and Jie Shao
    Citation: BMC Medicine 2023 21:167
    Content type: Research article Published on:

  39. Alzheimer’s disease (AD) pathology impairs cognitive function. Yet some individuals with high amounts of AD pathology suffer marked memory impairment, while others with the same degree of pathology burden show li...

    Authors: Zsófia Zavecz, Vyoma D. Shah, Olivia G. Murillo, Raphael Vallat, Bryce A. Mander, Joseph R. Winer, William J. Jagust and Matthew P. Walker
    Citation: BMC Medicine 2023 21:156
    Content type: Research article Published on:

  40. Long-term intake of a Western diet (WD), characterized by a high-fat content and sugary drinks, is hypothesized to contribute to the development of inflammatory bowel disease (IBD). Despite the identified clin...

    Authors: Woo-Jeong Shon, Jae Won Song, Seung Hoon Oh, Keon-Hee Lee, Hobin Seong, Hyun Ju You, Je Kyung Seong and Dong-Mi Shin
    Citation: BMC Medicine 2023 21:165
    Content type: Research article Published on:

  41. Furmonertinib (AST2818) is a brain penetrant pan-epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) targeting both EGFR sensitizing mutations and T790M mutation. We report the pooled central ...

    Authors: Xingsheng Hu, Shucai Zhang, Zhiyong Ma, Jifeng Feng, Lin Wu, Dongqing Lv, Jianying Zhou, Xiaodong Zhang, Li Liu, Qitao Yu, Wangjun Liao, Yiping Zhang, Xiang Wang, Ying Cheng, Hongrui Niu, Ziping Wang…
    Citation: BMC Medicine 2023 21:164
    Content type: Research article Published on:

  42. Considerable evidence has been reported that tobacco use could cause alterations in gut microbiota composition. The microbiota-gut–brain axis also in turn hinted at a possible contribution of the gut microbiot...

    Authors: Jiayao Fan, Yuan Zhou, Ran Meng, Jinsong Tang, Jiahao Zhu, Melinda C. Aldrich, Nancy J. Cox, Yimin Zhu, Yingjun Li and Dan Zhou
    Citation: BMC Medicine 2023 21:163
    Content type: Research article Published on:

  43. Maintaining oral health is essential for improving overall health of children living with HIV. Therefore, we evaluated the effectiveness of an oral health intervention for improving their oral and overall heal...

    Authors: Kimiyo Kikuchi, Sovannary Tuot, Junko Yasuoka, Makoto Murayama, Sumiyo Okawa, Akira Shibanuma, Keiko Nanishi, Sothearith Eng, Chantheany Huot and Siyan Yi
    Citation: BMC Medicine 2023 21:162
    Content type: Research article Published on:

  44. The objective response rate of microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC) patients with first-line anti-programmed cell death protein-1 (PD-1) monotherapy is only 40–45%. Singl...

    Authors: Tao Wu, Xuan Zhang, Xinxing Liu, Xinyi Cai, Tao Shen, Dingguo Pan, Rui Liang, Rong Ding, Ruixi Hu, Jianhua Dong, Furong Li, Jinsha Li, Lin Xie, Chunlong Wang, Shilei Geng, Zhaoyu Yang…
    Citation: BMC Medicine 2023 21:161
    Content type: Research article Published on:

  45. The two inactivated SARS-CoV-2 vaccines, CoronaVac and BBIBP-CorV, have been widely used to control the COVID-19 pandemic. The influence of multiple factors on inactivated vaccine effectiveness (VE) during lon...

    Authors: Shiyao Xu, Jincheng Li, Hongyuan Wang, Fuzhen Wang, Zundong Yin and Zhifeng Wang
    Citation: BMC Medicine 2023 21:160
    Content type: Research article Published on:

  46. Effective risk prediction models are lacking for personalized endoscopic screening of gastric cancer (GC). We aimed to develop, validate, and evaluate a questionnaire-based GC risk assessment tool for risk pre...

    Authors: Xia Zhu, Jun Lv, Meng Zhu, Caiwang Yan, Bin Deng, Canqing Yu, Yu Guo, Jing Ni, Qiang She, Tianpei Wang, Jiayu Wang, Yue Jiang, Jiaping Chen, Dong Hang, Ci Song, Xuefeng Gao…
    Citation: BMC Medicine 2023 21:159
    Content type: Research article Published on:

  47. C-type natriuretic peptide (CNP) is a known target for promoting growth and has been implicated as a therapeutic opportunity for the prevention and treatment of cardiovascular disease (CVD). This study aimed t...

    Authors: Héléne T. Cronjé, Ville Karhunen, G. Kees Hovingh, Ken Coppieters, Jens O. Lagerstedt, Michael Nyberg and Dipender Gill
    Citation: BMC Medicine 2023 21:158
    Content type: Research article Published on:

  48. SARS-CoV-2 mRNA vaccination has been associated with both side effects and a reduction in COVID-related complaints due to the decrease in COVID-19 incidence. We aimed to investigate if individuals who received...

    Authors: Fredrik Methi, Jon Michael Gran, Morten Valberg, Jonas Minet Kinge, Kjetil Telle and Karin Magnusson
    Citation: BMC Medicine 2023 21:157
    Content type: Research article Published on:

  49. Germline mosaicisms could be inherited to offspring, which considered as “de novo” in most cases. Paternal germline MECP2 mosaicism has been reported in fathers of girls with Rett syndrome (RTT) previously. For f...

    Authors: Yongxin Wen, Jiaping Wang, Qingping Zhang, Xiaoxu Yang, Liping Wei and Xinhua Bao
    Citation: BMC Medicine 2023 21:155
    Content type: Research article Published on:

  50. Dysfunctional adipose tissue (AT) is known to contribute to the pathophysiology of metabolic disease, including type 2 diabetes mellitus (T2DM). This dysfunction may occur, in part, as a consequence of gut-der...

    Authors: Farah Omran, Alice M. Murphy, Awais Z. Younis, Ioannis Kyrou, Jana Vrbikova, Vojtech Hainer, Petra Sramkova, Martin Fried, Graham Ball, Gyanendra Tripathi, Sudhesh Kumar, Philip G. McTernan and Mark Christian
    Citation: BMC Medicine 2023 21:154
    Content type: Research article Published on:
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