Skip to main content



Page 1 of 47

  1. Content type: Research article

    Different methodological choices such as inclusion/exclusion criteria and analytical models can yield different results and inferences when meta-analyses are performed. We explored the range of such difference...

    Authors: Clément Palpacuer, Karima Hammas, Renan Duprez, Bruno Laviolle, John P. A. Ioannidis and Florian Naudet

    Citation: BMC Medicine 2019 17:174

    Published on:

  2. Content type: Research article

    Wolbachia-infected mosquitoes reduce dengue virus transmission, and city-wide releases in Yogyakarta city, Indonesia, are showing promising entomological results. Accurate estimates of the burden of dengue, its s...

    Authors: Kathleen M. O’Reilly, Emilie Hendrickx, Dinar D. Kharisma, Nandyan N. Wilastonegoro, Lauren B. Carrington, Iqbal R. F. Elyazar, Adam J. Kucharski, Rachel Lowe, Stefan Flasche, David M. Pigott, Robert C. Reiner Jr, W. John Edmunds, Simon I. Hay, Laith Yakob, Donald S. Shepard and Oliver J. Brady

    Citation: BMC Medicine 2019 17:172

    Published on:

  3. Content type: Research article

    The epidemiology of CNS infections in Europe is dynamic, requiring that clinicians have access to up-to-date clinical management guidelines (CMGs) to aid identification of emerging infections and for improving...

    Authors: Louise Sigfrid, Chelsea Perfect, Amanda Rojek, Kajsa-Stina Longuere, Sam Lipworth, Eli Harriss, James Lee, Alex Salam, Gail Carson, Herman Goossens and Peter Horby

    Citation: BMC Medicine 2019 17:170

    Published on:

  4. Content type: Research article

    Diagnostic codes from electronic health records are widely used to assess patterns of disease. Infective endocarditis is an uncommon but serious infection, with objective diagnostic criteria. Electronic health...

    Authors: Nicola Fawcett, Bernadette Young, Leon Peto, T. Phuong Quan, Richard Gillott, Jianhua Wu, Chris Middlemass, Sheila Weston, Derrick W. Crook, Tim E. A. Peto, Berit Muller-Pebody, Alan P. Johnson, A. Sarah Walker and Jonathan A. T. Sandoe

    Citation: BMC Medicine 2019 17:169

    Published on:

  5. Content type: Research article

    Randomised control trials and genetic analyses have demonstrated that vitamin D or 25-hydroxyvitamin D (25[OH]D) levels may not play a causal role in the development of cardiovascular disease. However, it is u...

    Authors: Tao Huang, Shoaib Afzal, Canqing Yu, Yu Guo, Zheng Bian, Ling Yang, Iona Y. Millwood, Robin G. Walters, Yiping Chen, Ningyu Chen, Ruqin Gao, Junshi Chen, Robert Clarke, Zhengming Chen, Christina Ellervik, Børge G. Nordestgaard…

    Citation: BMC Medicine 2019 17:160

    Published on:

    The Commentary to this article has been published in BMC Medicine 2019 17:166

  6. Content type: Opinion

    Three large new trials of unprecedented scale and cost, which included novel factorial designs, have found no effect of basic water, sanitation and hygiene (WASH) interventions on childhood stunting, and only ...

    Authors: Oliver Cumming, Benjamin F. Arnold, Radu Ban, Thomas Clasen, Joanna Esteves Mills, Matthew C. Freeman, Bruce Gordon, Raymond Guiteras, Guy Howard, Paul R. Hunter, Richard B. Johnston, Amy J. Pickering, Andrew J. Prendergast, Annette Prüss-Ustün, Jan Willem Rosenboom, Dean Spears…

    Citation: BMC Medicine 2019 17:173

    Published on:

  7. Content type: Research article

    The alpha-adrenergic agonist phenylephrine is often used to treat hypotension during anesthesia. In clinical situations, low blood pressure may require prompt intervention by intravenous bolus or infusion. Dif...

    Authors: Yanfei Zhang, S. Mark Poler, Jiang Li, Vida Abedi, Sarah A. Pendergrass, Marc S. Williams and Ming Ta Michael Lee

    Citation: BMC Medicine 2019 17:168

    Published on:

  8. Content type: Research article

    The objective of this cross-sectional study was to explore the relationship of detectable C-peptide secretion in type 1 diabetes to clinical features and to the genetic architecture of diabetes.

    Authors: Paul M. McKeigue, Athina Spiliopoulou, Stuart McGurnaghan, Marco Colombo, Luke Blackbourn, Timothy J. McDonald, Suna Onengut-Gomuscu, Stephen S. Rich, Colin N. A. Palmer, John A. McKnight, Mark W. J. Strachan, Alan W. Patrick, John Chalmers, Robert S. Lindsay, John R. Petrie, Sandeep Thekkepat…

    Citation: BMC Medicine 2019 17:165

    Published on:

    A Letter has been published.

  9. Content type: Guideline

    Despite the increasing popularity of multi-model comparison studies and their ability to inform policy recommendations, clear guidance on how to conduct multi-model comparisons is not available. Herein, we pre...

    Authors: Saskia den Boon, Mark Jit, Marc Brisson, Graham Medley, Philippe Beutels, Richard White, Stefan Flasche, T. Déirdre Hollingsworth, Tini Garske, Virginia E. Pitzer, Martine Hoogendoorn, Oliver Geffen, Andrew Clark, Jane Kim and Raymond Hutubessy

    Citation: BMC Medicine 2019 17:163

    Published on:

  10. Content type: Research article

    Cannabis is the most commonly used illicit substance amongst people with psychosis. Continued cannabis use following the onset of psychosis is associated with poorer functional and clinical outcomes. However, ...

    Authors: Luke Sheridan Rains, Louise Marston, Mark Hinton, Steven Marwaha, Thomas Craig, David Fowler, Michael King, Rumana Z. Omar, Paul McCrone, Jonathan Spencer, Joanne Taylor, Sophie Colman, Catherine Harder, Eleanor Gilbert, Amie Randhawa, Kirsty Labuschagne…

    Citation: BMC Medicine 2019 17:161

    Published on:

  11. Content type: Research article

    Vaccination and naturally acquired immunity against microbial pathogens may have complex interactions that influence disease outcomes. To date, only vaccine-specific immune responses have routinely been invest...

    Authors: Carlota Dobaño, Itziar Ubillos, Chenjerai Jairoce, Ben Gyan, Marta Vidal, Alfons Jiménez, Rebeca Santano, David Dosoo, Augusto J. Nhabomba, Aintzane Ayestaran, Ruth Aguilar, Nana Aba Williams, Núria Díez-Padrisa, David Lanar, Virander Chauhan, Chetan Chitnis…

    Citation: BMC Medicine 2019 17:157

    Published on:

  12. Content type: Research article

    The optimal dose of rabbit antithymocyte globulin (ATG, ImtixSangstat) minimizing infections without increasing graft-versus-host disease (GVHD) is unknown in T cell-replete, G-CSF-primed haploidentical hemato...

    Authors: Ren Lin, Yu Wang, Fen Huang, Zhiping Fan, Shen Zhang, Ting Yang, Yajing Xu, Na Xu, Li Xuan, Jieyu Ye, Jing Sun, Xiaojun Huang and Qifa Liu

    Citation: BMC Medicine 2019 17:156

    Published on:

  13. Content type: Correction

    The original article [1] contained an error in the abstract. The mentioned cohort size now correctly states ‘N = 3,855,660’.

    Authors: Alexander Pate, Richard Emsley, Darren M. Ashcroft, Benjamin Brown and Tjeerd van Staa

    Citation: BMC Medicine 2019 17:158

    Published on:

    The original article was published in BMC Medicine 2019 17:134

  14. Content type: Research article

    Antibiotic-induced disturbances of the human microbiota have been implicated in the development of chronic autoimmune conditions. This study aimed to assess whether antibiotic use is associated with the onset ...

    Authors: Alyshah Abdul Sultan, Christian Mallen, Sara Muller, Samantha Hider, Ian Scott, Toby Helliwell and Lindsay J. Hall

    Citation: BMC Medicine 2019 17:154

    Published on:

  15. Content type: Research article

    India and many other high-burden countries have committed to providing universal access to high-quality diagnosis and drug susceptibility testing (DST) for tuberculosis (TB), but the most cost-effective approa...

    Authors: Hojoon Sohn, Parastu Kasaie, Emily Kendall, Gabriela B. Gomez, Anna Vassall, Madhukar Pai and David Dowdy

    Citation: BMC Medicine 2019 17:155

    Published on:

  16. Content type: Correspondence

    Pregnant women are highly susceptible to anaemia and iron deficiency due to the increased demands of pregnancy as well as other factors. Iron supplementation is recommended in pregnancy, yet the benefits on ne...

    Authors: Freya J. I. Fowkes, Eliza Davidson, Paul A. Agius and James G. Beeson

    Citation: BMC Medicine 2019 17:153

    Published on:

    The original article was published in BMC Medicine 2019 17:146

  17. Content type: Research article

    Malaria causes a reduction in haemoglobin that is compounded by primaquine, particularly in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. The aim of this study was to determine the relativ...

    Authors: Robert J. Commons, Julie A. Simpson, Kamala Thriemer, Cindy S. Chu, Nicholas M. Douglas, Tesfay Abreha, Sisay G. Alemu, Arletta Añez, Nicholas M. Anstey, Abraham Aseffa, Ashenafi Assefa, Ghulam R. Awab, J. Kevin Baird, Bridget E. Barber, Isabelle Borghini-Fuhrer, Umberto D’Alessandro…

    Citation: BMC Medicine 2019 17:151

    Published on:

  18. Content type: Research article

    Persons with human immunodeficiency virus (HIV) have higher risks for myocardial infarction (MI) than the general population. This is driven in part by higher type 2 MI (T2MI, due to coronary supply-demand mis...

    Authors: Matthew J. Feinstein, Robin M. Nance, J. A. Chris Delaney, Susan R. Heckbert, Matthew J. Budoff, Daniel R. Drozd, Greer A. Burkholder, James H. Willig, Michael J. Mugavero, William C. Mathews, Richard D. Moore, Joseph J. Eron, Sonia Napravnik, Peter W. Hunt, Elvin Geng, Priscilla Hsue…

    Citation: BMC Medicine 2019 17:149

    Published on:

  19. Content type: Research article

    Colorectal cancer is the third most common cancer in the world. In this study, we assessed the long-term survival characteristics and prognostic associations and potential time-varying effects of clinico-demog...

    Authors: Yajun Yu, Megan Carey, William Pollett, Jane Green, Elizabeth Dicks, Patrick Parfrey, Yildiz E. Yilmaz and Sevtap Savas

    Citation: BMC Medicine 2019 17:150

    Published on:

  20. Content type: Correction

    Figure 3 in the original article [1] is incorrect; labels for secondary outcomes have been shifted and do not correspond to the numbers reported in the table (Additional file 8). The corrected version can be s...

    Authors: Isabelle Boutron, Romana Haneef, Amélie Yavchitz, Gabriel Baron, John Novack, Ivan Oransky, Gary Schwitzer and Philippe Ravaud

    Citation: BMC Medicine 2019 17:147

    Published on:

    The original article was published in BMC Medicine 2019 17:105

  21. Content type: Correspondence

    A recent cohort study among Papua New Guinean women surprisingly showed iron deficiency during pregnancy to be associated with increased birth weight. These findings seemingly contradict previous trial evidenc...

    Authors: Hans Verhoef, Martin N. Mwangi, Carla Cerami and Andrew M. Prentice

    Citation: BMC Medicine 2019 17:146

    Published on:

    The Correspondence to this article has been published in BMC Medicine 2019 17:153

    The original article was published in BMC Medicine 2018 16:156

  22. Content type: Research article

    The presence of additional chronic conditions has a significant impact on the treatment and management of type 2 diabetes (T2DM). Little is known about the patterns of comorbidities in this population. The aim...

    Authors: Magdalena Nowakowska, Salwa S. Zghebi, Darren M. Ashcroft, Iain Buchan, Carolyn Chew-Graham, Tim Holt, Christian Mallen, Harm Van Marwijk, Niels Peek, Rafael Perera-Salazar, David Reeves, Martin K. Rutter, Stephen F. Weng, Nadeem Qureshi, Mamas A. Mamas and Evangelos Kontopantelis

    Citation: BMC Medicine 2019 17:145

    Published on:

  23. Content type: Research article

    Delirium affects > 15% of hospitalised patients but is grossly underdetected, contributing to poor care. The 4 ‘A’s Test (4AT, www.​the4AT.​com) is a sho...

    Authors: Susan D. Shenkin, Christopher Fox, Mary Godfrey, Najma Siddiqi, Steve Goodacre, John Young, Atul Anand, Alasdair Gray, Janet Hanley, Allan MacRaild, Jill Steven, Polly L. Black, Zoë Tieges, Julia Boyd, Jacqueline Stephen, Christopher J. Weir…

    Citation: BMC Medicine 2019 17:138

    Published on:

  24. Content type: Review

    Celiac disease remains a challenging condition because of a steady increase in knowledge tackling its pathophysiology, diagnosis, management, and possible therapeutic options.

    Authors: Giacomo Caio, Umberto Volta, Anna Sapone, Daniel A. Leffler, Roberto De Giorgio, Carlo Catassi and Alessio Fasano

    Citation: BMC Medicine 2019 17:142

    Published on:

  25. Content type: Research article

    Since low insulin-like growth factor (IGF) 1 is often linked to inflammation, we analyze whether serum levels of IGF1 are associated with cardiovascular disease (CVD) in rheumatoid arthritis (RA) in a longitud...

    Authors: Malin C. Erlandsson, Lovisa Lyngfelt, N. David Åberg, Caroline Wasén, Rachelle A. Espino, Sofia Töyrä Silfverswärd, Mitra Nadali, Katharina Jood, Karin M.E. Andersson, Rille Pullerits and Maria I. Bokarewa

    Citation: BMC Medicine 2019 17:141

    Published on:

  26. Content type: Correction

    Since the publication of this article [1] it has come to my attention that it contains an error in which the y-axis in Fig. 1 was inverted, thus incorrectly displaying a weak negative correlation rather than a...

    Authors: Jeremy C. Wyatt

    Citation: BMC Medicine 2019 17:144

    Published on:

    The original article was published in BMC Medicine 2018 16:225

  27. Content type: Research article

    The objectives of this study were to understand the differences in mortality rate, risk factors for mortality, and cause of death distribution in three neonatal age sub-groups (0–2, 3–7, and 8–27 days) and ass...

    Authors: Rakhi Dandona, G. Anil Kumar, Debarshi Bhattacharya, Md. Akbar, Yamini Atmavilas, Priya Nanda and Lalit Dandona

    Citation: BMC Medicine 2019 17:140

    Published on:

  28. Content type: Research article

    Clinical practice guidelines are an important source of information, designed to help clinicians integrate research evidence into their clinical practice. Digital education is increasingly used for clinical pr...

    Authors: Lorainne Tudor Car, Aijia Soong, Bhone Myint Kyaw, Kee Leng Chua, Naomi Low-Beer and Azeem Majeed

    Citation: BMC Medicine 2019 17:139

    Published on:

  29. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver illness with a genetically heterogeneous background that can be accompanied by considerable morbidity and attendant health care costs. The pa...

    Authors: Bahram Namjou, Todd Lingren, Yongbo Huang, Sreeja Parameswaran, Beth L. Cobb, Ian B. Stanaway, John J. Connolly, Frank D. Mentch, Barbara Benoit, Xinnan Niu, Wei-Qi Wei, Robert J. Carroll, Jennifer A. Pacheco, Isaac T. W. Harley, Senad Divanovic, David S. Carrell…

    Citation: BMC Medicine 2019 17:135

    Published on:

  30. Content type: Research article

    Risk prediction models are commonly used in practice to inform decisions on patients’ treatment. Uncertainty around risk scores beyond the confidence interval is rarely explored. We conducted an uncertainty an...

    Authors: Alexander Pate, Richard Emsley, Darren M. Ashcroft, Benjamin Brown and Tjeerd van Staa

    Citation: BMC Medicine 2019 17:134

    Published on:

    The Correction to this article has been published in BMC Medicine 2019 17:158

  31. Content type: Debate

    There is great interest in and excitement about the concept of personalized or precision medicine and, in particular, advancing this vision via various ‘big data’ efforts. While these methods are necessary, th...

    Authors: Eric B. Hekler, Predrag Klasnja, Guillaume Chevance, Natalie M. Golaszewski, Dana Lewis and Ida Sim

    Citation: BMC Medicine 2019 17:133

    Published on:

  32. Content type: Research article

    Smartphone apps are becoming increasingly popular for supporting diabetes self-management. A key aspect of diabetes self-management is appropriate medication-taking. This study aims to systematically assess an...

    Authors: Zhilian Huang, Elaine Lum, Geronimo Jimenez, Monika Semwal, Peter Sloot and Josip Car

    Citation: BMC Medicine 2019 17:127

    Published on:

  33. Content type: Research article

    Hospitalisation is often harmful for people with dementia and results in high societal costs, so avoidance of unnecessary admissions is a global priority. However, no intervention has yet reduced admissions of...

    Authors: Hilary Shepherd, Gill Livingston, Justin Chan and Andrew Sommerlad

    Citation: BMC Medicine 2019 17:130

    Published on:

  34. Content type: Research article

    Studies have suggested sex differences in the mortality rate associated with diabetes. We conducted a meta-analysis to estimate the relative effect of diabetes on the risk of all-cause, cancer, cardiovascular ...

    Authors: Yafeng Wang, Adrienne O’Neil, Yurui Jiao, Lijun Wang, Jingxin Huang, Yutao Lan, Yikun Zhu and Chuanhua Yu

    Citation: BMC Medicine 2019 17:136

    Published on:

  35. Content type: Research article

    Monogenic diabetes (MgD) accounts for 1–2% of all diabetes cases. In adults, MgD is difficult to distinguish from common diabetes causes. We assessed the diagnosis rate and genetic spectrum of MgD using next-g...

    Authors: Xavier Donath, Cécile Saint-Martin, Danièle Dubois-Laforgue, Ramanan Rajasingham, François Mifsud, Cécile Ciangura, José Timsit and Christine Bellanné-Chantelot

    Citation: BMC Medicine 2019 17:132

    Published on:

  36. Content type: Research article

    Autoimmune diseases are often preceded by an asymptomatic autoantibody-positive phase. In type 1 diabetes, the detection of autoantibodies to pancreatic islet antigens in genetically at-risk children is progno...

    Authors: Verena Sophia Hoffmann, Andreas Weiß, Christiane Winkler, Annette Knopff, Manja Jolink, Ezio Bonifacio and Anette-G. Ziegler

    Citation: BMC Medicine 2019 17:125

    Published on:

  37. Content type: Research article

    Many parts of Africa have witnessed reductions in Plasmodium falciparum transmission over the last 15 years. Since immunity to malaria is acquired more rapidly at higher transmission, the slower acquisition of im...

    Authors: Patricia Njuguna, Kathryn Maitland, Amek Nyaguara, Daniel Mwanga, Polycarp Mogeni, Neema Mturi, Shebe Mohammed, Gabriel Mwambingu, Caroline Ngetsa, Kenedy Awuondo, Brett Lowe, Ifedayo Adetifa, J. Anthony G. Scott, Thomas N. Williams, Sarah Atkinson, Faith Osier…

    Citation: BMC Medicine 2019 17:124

    Published on:

  38. Content type: Research article

    Every year, 90,000 people may die from melioidosis. Vaccine candidates have not proceeded past animal studies, partly due to uncertainty around the potential market size. This study aims to estimate the potent...

    Authors: Nantasit Luangasanatip, Stefan Flasche, David A. B. Dance, Direk Limmathurotsakul, Bart J. Currie, Chiranjay Mukhopadhyay, Tim Atkins, Richard Titball and Mark Jit

    Citation: BMC Medicine 2019 17:129

    Published on: