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  1. Tobacco smoking affects women’s fertility and is associated with substantial risks of adverse pregnancy outcomes. This study explored trends by socioeconomic position in patterns of smoking, use of non-combust...

    Authors: Sarah E. Jackson, Jamie Brown, Caitlin Notley, Lion Shahab and Sharon Cox
    Citation: BMC Medicine 2024 22:99
  2. The metabolic benefits of bariatric surgery that contribute to the alleviation of metabolic dysfunction-associated steatotic liver disease (MASLD) have been reported. However, the processes and mechanisms unde...

    Authors: Chengcan Yang, Dongzi Zhu, Chaofan Liu, Wenyue Wang, Yining He, Bing Wang and Meiyi Li
    Citation: BMC Medicine 2024 22:164
  3. Defining healthcare facility catchment areas is a key step in predicting future healthcare demand in epidemic settings. Forecasts of hospitalisations can be informed by leading indicators measured at the commu...

    Authors: Sophie Meakin and Sebastian Funk
    Citation: BMC Medicine 2024 22:163
  4. The COVID-19 pandemic resulted in major inequalities in infection and disease burden between areas of varying socioeconomic deprivation in many countries, including England. Areas of higher deprivation tend to...

    Authors: Lucy Goodfellow, Edwin van Leeuwen and Rosalind M. Eggo
    Citation: BMC Medicine 2024 22:162
  5. To study the shared genetic structure between autoimmune diseases and B-cell acute lymphoblastic leukemia (B-ALL) and identify the shared risk loci and genes and genetic mechanisms involved.

    Authors: Xinghao Yu, Yiyin Chen, Jia Chen, Yi Fan, Huimin Lu, Depei Wu and Yang Xu
    Citation: BMC Medicine 2024 22:161
  6. Lung health is increasingly recognized as an essential factor in mental health. However, prospective evidence on lung function with incident depression remains to be determined. The study aimed to examine the ...

    Authors: Wei Hu, Bao-Peng Liu and Cun-Xian Jia
    Citation: BMC Medicine 2024 22:160
  7. Long covid (post covid-19 condition) is a complex condition with diverse manifestations, uncertain prognosis and wide variation in current approaches to management. There have been calls for formal quality sta...

    Authors: Trisha Greenhalgh, Julie L. Darbyshire, Cassie Lee, Emma Ladds and Jenny Ceolta-Smith
    Citation: BMC Medicine 2024 22:159
  8. ANKRD11 (ankyrin repeat domain 11) is a chromatin regulator and the only gene associated with KBG syndrome, a rare neurodevelopmental disorder. We have previously shown that Ankrd11 regulates murine embryonic cor...

    Authors: Kara Goodkey, Anita Wischmeijer, Laurence Perrin, Adrianne E. S. Watson, Leenah Qureshi, Duccio Maria Cordelli, Francesco Toni, Maria Gnazzo, Francesco Benedicenti, Monique Elmaleh-Bergès, Karen J. Low and Anastassia Voronova
    Citation: BMC Medicine 2024 22:158
  9. Autism spectrum disorder (hereafter referred to as autism) is characterised by difficulties with (i) social communication, social interaction, and (ii) restricted and repetitive interests and behaviours. Estim...

    Authors: Emma Woodhouse, Jack Hollingdale, Lisa Davies, Zainab Al-Attar, Susan Young, Luke P. Vinter, Kwaku Agyemang, Carla Bartlett, Colleen Berryessa, Eddie Chaplin, Quinton Deeley, Ian Freckelton, Felicity Gerry, Gisli Gudjonsson, Katie Maras, Michelle Mattison…
    Citation: BMC Medicine 2024 22:157
  10. Chronic low back pain (CLBP) is a significant problem affecting millions of people worldwide. Three widely implemented psychological techniques used for CLBP management are cognitive therapy (CT), mindfulness ...

    Authors: Melissa A. Day, Marcia A. Ciol, M. Elena Mendoza, Jeffrey Borckardt, Dawn M. Ehde, Andrea K. Newman, Joy F. Chan, Sydney A. Drever, Janna L. Friedly, John Burns, Beverly E. Thorn and Mark P. Jensen
    Citation: BMC Medicine 2024 22:156
  11. The timing of puberty may have an important impact on adolescent mental health. In particular, earlier age at menarche has been associated with elevated rates of depression in adolescents. Previous research su...

    Authors: Adrian Dahl Askelund, Robyn E. Wootton, Fartein A. Torvik, Rebecca B. Lawn, Helga Ask, Elizabeth C. Corfield, Maria C. Magnus, Ted Reichborn-Kjennerud, Per M. Magnus, Ole A. Andreassen, Camilla Stoltenberg, George Davey Smith, Neil M. Davies, Alexandra Havdahl and Laurie J. Hannigan
    Citation: BMC Medicine 2024 22:155
  12. Colorectal cancer (CRC) lacks established biomarkers or molecular targets for predicting or enhancing radiation response. Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 2 (PREX2) exhibit...

    Authors: Mingzhou Li, Jianbiao Xiao, Shasha Song, Fangyi Han, Hongling Liu, Yang Lin, Yunfei Ni, Sisi Zeng, Xin Zou, Jieqiong Wu, Feifei Wang, Shaowan Xu, You Liang, Peishuang Xu, Huirong Hong, Junfeng Qiu…
    Citation: BMC Medicine 2024 22:154
  13. Prediction of lymph node metastasis (LNM) is critical for individualized management of papillary thyroid carcinoma (PTC) patients to avoid unnecessary overtreatment as well as undesired under-treatment. Artifi...

    Authors: Ming-Bo Zhang, Zhe-Ling Meng, Yi Mao, Xue Jiang, Ning Xu, Qing-Hua Xu, Jie Tian, Yu-Kun Luo and Kun Wang
    Citation: BMC Medicine 2024 22:153
  14. Despite substantial research revealing that patients with rheumatoid arthritis (RA) have excessive morbidity and mortality of cardiovascular disease (CVD), the mechanism underlying this association has not bee...

    Authors: Xiaohui Sun, Yu Qian, Weiqiu Cheng, Ding Ye, Bin Liu, Dan Zhou, Chengping Wen, Ole A. Andreassen and Yingying Mao
    Citation: BMC Medicine 2024 22:152
  15. Clinical complexity, as the interaction between ageing, frailty, multimorbidity and polypharmacy, is an increasing concern in patients with AF. There remains uncertainty regarding how combinations of comorbidi...

    Authors: Giulio Francesco Romiti, Bernadette Corica, Davide Antonio Mei, Arnaud Bisson, Giuseppe Boriani, Brian Olshansky, Tze-Fan Chao, Menno V. Huisman, Marco Proietti and Gregory Y. H. Lip
    Citation: BMC Medicine 2024 22:151
  16. There has been a precipitous decline in authorizations for medical cannabis since non-medical cannabis was legalized in Canada in 2018. This study examines the demographic and health- and medical cannabis-rela...

    Authors: Lynda G. Balneaves, Ashleigh Brown, Matthew Green, Erin Prosk, Lucile Rapin, Max Monahan-Ellison, Eva McMillan, Jonathan Zaid, Michael Dworkind and Cody Z. Watling
    Citation: BMC Medicine 2024 22:150
  17. Various studies have demonstrated gender disparities in workplace settings and the need for further intervention. This study identifies and examines evidence from randomized controlled trials (RCTs) on interve...

    Authors: Andrea C. Tricco, Amanda Parker, Paul A. Khan, Vera Nincic, Reid Robson, Heather MacDonald, Rachel Warren, Olga Cleary, Elaine Zibrowski, Nancy Baxter, Karen E. A. Burns, Doug Coyle, Ruth Ndjaboue, Jocalyn P. Clark, Etienne V. Langlois, Sofia B. Ahmed…
    Citation: BMC Medicine 2024 22:149
  18. Indobufen is widely used in patients with aspirin intolerance in East Asia. The OPTION trial launched by our cardiac center examined the performance of indobufen based dual antiplatelet therapy (DAPT) after pe...

    Authors: Chunfeng Dai, Muyin Liu, Zheng Yang, Youran Li, You Zhou, Danbo Lu, Yan Xia, Ao Chen, Chenguang Li, Hao Lu, Yuxiang Dai, Jianying Ma, Zhangwei Chen, Juying Qian and Junbo Ge
    Citation: BMC Medicine 2024 22:148
  19. Thyroid nodule (TN) patients in China are subject to overdiagnosis and overtreatment. The implementation of existing technologies such as thyroid ultrasonography has indeed contributed to the improved diagnost...

    Authors: Feihang Wang, Danyang Zhao, Wang-yang Xu, Yiying Liu, Huiyi Sun, Shanshan Lu, Yuan Ji, Jingjing Jiang, Yi Chen, Qiye He, Chengxiang Gong, Rui Liu, Zhixi Su, Yi Dong, Zhiping Yan and Lingxiao Liu
    Citation: BMC Medicine 2024 22:147
  20. Childhoods in urban or rural environments may differentially affect the risk of neuropsychiatric disorders, possibly through memory processing and neural response to emotional stimuli. Genetic factors may not ...

    Authors: Xiao Zhang, Yuyanan Zhang, Hao Yan, Hao Yu, Dai Zhang, Venkata S. Mattay, Hao Yang Tan and Weihua Yue
    Citation: BMC Medicine 2024 22:146
  21. Technology-enabled inpatient-level care at home services, such as virtual wards and hospital at home, are being rapidly implemented. This is the first systematic review to link the components of these service ...

    Authors: Chunhu Shi, Jo Dumville, Fernando Rubinstein, Gill Norman, Akbar Ullah, Saima Bashir, Peter Bower and Emma R. L. C. Vardy
    Citation: BMC Medicine 2024 22:145
  22. Type 2 diabetes in young people is an aggressive disease with a greater risk of complications leading to increased morbidity and mortality during the most productive years of life. Prevalence in the UK and glo...

    Authors: Billy White, S. M. Ng, J. C. Agwu, T. G. Barrett, N. Birchmore, M. Kershaw, J. Drew, F. Kavvoura, J. Law, C. Moudiotis, E. Procter, P. Paul, F. Regan, P. Reilly, P. Sachdev, R. Sakremath…
    Citation: BMC Medicine 2024 22:144
  23. Temporary doctors, known as locums, are a key component of the medical workforce in the NHS but evidence on differences in quality and safety between locum and permanent doctors is limited. We aimed to examine...

    Authors: Christos Grigoroglou, Kieran Walshe, Evangelos Kontopantelis, Jane Ferguson, Gemma Stringer, Darren M. Ashcroft and Thomas Allen
    Citation: BMC Medicine 2024 22:126
  24. Syndromic surveillance often relies on patients presenting to healthcare. Community cohorts, although more challenging to recruit, could provide additional population-wide insights, particularly with SARS-CoV-...

    Authors: Elisabeth Dietz, Emma Pritchard, Koen Pouwels, Muhammad Ehsaan, Joshua Blake, Charlotte Gaughan, Eric Haduli, Hugh Boothe, Karina-Doris Vihta, Tim Peto, Nicole Stoesser, Philippa Matthews, Nick Taylor, Ian Diamond, Ruth Studley, Emma Rourke…
    Citation: BMC Medicine 2024 22:143
  25. Chronic graft-versus-host disease (cGVHD) is an immune-related disorder that is the most common complication post-allogenic hematopoietic stem cell transplant. Corticosteroids with or without calcineurin inhib...

    Authors: Ying Wang, Depei Wu, Xiang Zhang, Yuhua Li, Yanjie He, Qifa Liu, Li Xuan, Zhenyu Li, Kunming Qi, Yuqian Sun, Shunqing Wang, Wenjian Mo, Lei Gao, Ye Hua, Yu Wang and Ying Zhang
    Citation: BMC Medicine 2024 22:142
  26. Previous studies have shown that lifestyle/environmental factors could accelerate the development of age-related hearing loss (ARHL). However, there has not yet been a study investigating the joint association...

    Authors: Sang-Hyuk Jung, Young Chan Lee, Manu Shivakumar, Jaeyoung Kim, Jae-Seung Yun, Woong-Yang Park, Hong-Hee Won and Dokyoon Kim
    Citation: BMC Medicine 2024 22:141
  27. It is well-established that parental obesity is a strong risk factor for offspring obesity. Further, a converging body of evidence now suggests that maternal weight profiles may affect the developing offspring...

    Authors: Aylin Rosberg, Harri Merisaari, John D. Lewis, Niloofar Hashempour, Minna Lukkarinen, Jerod M. Rasmussen, Noora M. Scheinin, Linnea Karlsson, Hasse Karlsson and Jetro J. Tuulari
    Citation: BMC Medicine 2024 22:140
  28. The National Health Service in England aims to implement tobacco dependency treatment services in all hospitals by 2024. We aimed to assess the uptake of a new service, adapted from the Ottawa Model of Smoking...

    Authors: John Robins, Irem Patel, Ann McNeill, John Moxham, Arran Woodhouse, Gareth Absalom, Buljana Shehu, Geraldine Bruce, Amy Dewar, Alanna Molloy, Stephanie Duckworth Porras, Michael Waring, Andrew Stock and Debbie Robson
    Citation: BMC Medicine 2024 22:139
  29. Synaptic dysfunction with reduced synaptic protein levels is a core feature of Alzheimer’s disease (AD). Synaptic proteins play a central role in memory processing, learning, and AD pathogenesis. Evidence sugg...

    Authors: Huimin Cai, Yana Pang, Ziye Ren, Xiaofeng Fu and Longfei Jia
    Citation: BMC Medicine 2024 22:138
  30. Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), has been associated with several cancer risks in observational studies, but the observed associations have bee...

    Authors: Di Liu, Meiling Cao, Haotian Wang, Weijie Cao, Chenguang Zheng, Yun Li and Youxin Wang
    Citation: BMC Medicine 2024 22:137
  31. Despite the importance of medication adherence in treatment effectiveness, little is known about the association between medication non-adherence and self-inflicted violence behaviors. We aimed to assess wheth...

    Authors: Chuanlong Zuo, Xianmei Yang, Xiangrui Wu, Ruoxin Fan, Jun Liu, Hu Xiang, Yang Li, Xing Zhao, Xiang Liu and Yuanyuan Liu
    Citation: BMC Medicine 2024 22:136
  32. Childhood maltreatment is common globally and impacts morbidity, mortality, and well-being. Our understanding of its impact is constrained by key substantive and methodological limitations of extant research, ...

    Authors: Ana Lucia Espinosa Dice, Rebecca B. Lawn, Andrew Ratanatharathorn, Andrea L. Roberts, Christy A. Denckla, Ariel H. Kim, Pedro A. de la Rosa, Yiwen Zhu, Tyler J. VanderWeele and Karestan C. Koenen
    Citation: BMC Medicine 2024 22:135
  33. Alterations in sleep have been described in multiple health conditions and as a function of several medication effects. However, evidence generally stems from small univariate studies. Here, we apply a large-s...

    Authors: Péter Przemyslaw Ujma and Róbert Bódizs
    Citation: BMC Medicine 2024 22:134
  34. Sarcopenic obesity, a clinical and functional condition characterized by the coexistence of obesity and sarcopenia, has not been investigated in relation to dementia risk and its onset.

    Authors: Junhan Zhang, Xiaona Na, Zhihui Li, John S. Ji, Guowei Li, Haibing Yang, Yucheng Yang, Yuefeng Tan, Jian Zhang, Menglu Xi, Donghan Su, Huatang Zeng, Liqun Wu and Ai Zhao
    Citation: BMC Medicine 2024 22:133
  35. The impact of sodium intake on cardiovascular disease (CVD) health and mortality has been studied for decades, including the well-established association with blood pressure. However, non-linear patterns, dose...

    Authors: Lu Gan, Bin Zhao, Maki Inoue-Choi, Linda M. Liao, Barry I. Graubard, Stephanie J. Weinstein, Demetrius Albanes and Jiaqi Huang
    Citation: BMC Medicine 2024 22:132
  36. Pandemics and climate change each challenge health systems through increasing numbers and new types of patients. To adapt to these challenges, leading health systems have embraced a Learning Health System (LHS...

    Authors: Carolynn L. Smith, Georgia Fisher, Putu Novi Arfirsta Dharmayani, Shalini Wijekulasuriya, Louise A. Ellis, Samantha Spanos, Genevieve Dammery, Yvonne Zurynski and Jeffrey Braithwaite
    Citation: BMC Medicine 2024 22:131
  37. Comprehensive data on patients at high risk of sudden cardiac death (SCD) in emerging countries are lacking. The aim was to deepen our understanding of the SCD phenotype and identify risk factors for death amo...

    Authors: Shuang Zhao, Chi-Keong Ching, Dejia Huang, Yen-Bin Liu, Diego A. Rodriguez-Guerrero, Azlan Hussin, Young-Hoon Kim, Brian Van Dorn, Xiaohong Zhou, Balbir Singh and Shu Zhang
    Citation: BMC Medicine 2024 22:130
  38. There is a growing population of children with in utero HIV exposure who are at risk of poor neurodevelopmental outcomes despite avoiding HIV infection. However, the underlying neurobiological pathways are not...

    Authors: Catherine J. Wedderburn, Shunmay Yeung, Sivenesi Subramoney, Jean-Paul Fouche, Shantanu H. Joshi, Katherine L. Narr, Andrea M. Rehman, Annerine Roos, Diana M. Gibb, Heather J. Zar, Dan J. Stein and Kirsten A. Donald
    Citation: BMC Medicine 2024 22:129
  39. Authors: Naomi R. Waterlow, Jackie Kleynhans, Nicole Wolter, Stefano Tempia, Rosalind M. Eggo, Orienka Hellferscee, Limakatso Lebina, Neil Martinson, Ryan G. Wagner, Jocelyn Moyes, Anne von Gottberg, Cheryl Cohen and Stefan Flasche
    Citation: BMC Medicine 2024 22:128

    The original article was published in BMC Medicine 2023 21:441

  40. While the augmented incidence of diabetes after COVID-19 has been widely confirmed, controversial results are available on the risk of developing hypertension during the COVID-19 pandemic.

    Authors: Valentina Trimarco, Raffaele Izzo, Daniela Pacella, Ugo Trama, Maria Virginia Manzi, Angela Lombardi, Roberto Piccinocchi, Paola Gallo, Giovanni Esposito, Gaetano Piccinocchi, Maria Lembo, Carmine Morisco, Francesco Rozza, Gaetano Santulli and Bruno Trimarco
    Citation: BMC Medicine 2024 22:127
  41. Highlighted by the rise of COVID-19, climate change, and conflict, socially vulnerable populations are least resilient to disaster. In infectious disease management, mathematical models are a commonly used too...

    Authors: Megan Naidoo, Whitney Shephard, Innocensia Kambewe, Nokuthula Mtshali, Sky Cope, Felipe Alves Rubio and Davide Rasella
    Citation: BMC Medicine 2024 22:125
  42. Several neurological manifestations shortly after a receipt of coronavirus infectious disease 2019 (COVID-19) vaccine have been described in the recent case reports. Among those, we sought to evaluate the risk...

    Authors: Ju Hwan Kim, Dongwon Yoon, Hwa Yeon Ko, Kyungyeon Jung, Jun-Sang Sunwoo, Won Chul Shin, Jung-Ick Byun and Ju-Young Shin
    Citation: BMC Medicine 2024 22:123
  43. Patients with fibro-calcific aortic valve disease (FCAVD) have lipid depositions in their aortic valve that engender a proinflammatory impetus toward fibrosis and calcification and ultimately valve leaflet ste...

    Authors: Dohee Yoon, Bongkun Choi, Ji-Eun Kim, Eun-Young Kim, Soo-Hyun Chung, Hyo-Jin Min, Yoolim Sung, Eun-Ju Chang and Jae-Kwan Song
    Citation: BMC Medicine 2024 22:122
  44. Socio-emotional impairments are among the diagnostic criteria for autism spectrum disorder (ASD), but the actual knowledge has substantiated both altered and intact emotional prosodies recognition. Here, a Bay...

    Authors: Mathilde Marie Duville, Luz María Alonso-Valerdi and David I. Ibarra-Zarate
    Citation: BMC Medicine 2024 22:121
  45. Numerous observational studies have highlighted associations of genetic predisposition of head and neck squamous cell carcinoma (HNSCC) with diverse risk factors, but these findings are constrained by design l...

    Authors: Young Chan Lee, Sang-Hyuk Jung, Manu Shivakumar, Soojin Cha, Woong-Yang Park, Hong-Hee Won, Young-Gyu Eun, Penn Medicine Biobank and Dokyoon Kim
    Citation: BMC Medicine 2024 22:120
  46. Intravenous leiomyomatosis (IVL), pulmonary benign metastatic leiomyomatosis (PBML), and leiomyomatosis peritonealis disseminata (LPD) are leiomyomas with special growth patterns and high postoperative recurre...

    Authors: Guorui Zhang, Rong Fan, Hua Yang, Hao Su, Xin Yu, Yutong Wang, Fengzhi Feng and Lan Zhu
    Citation: BMC Medicine 2024 22:119
  47. Paxlovid has been shown to be effective in reducing mortality and hospitalization rates in patients with coronavirus disease 2019 (COVID-19). It is not known whether Paxlovid can reduce the risk of cardiovascu...

    Authors: Weijie Wang, Yu-Hsun Wang, Ching-Hua Huang, Tsung-Hsueh Hsieh, Gema Hernández Ibarburu and James Cheng-Chung Wei
    Citation: BMC Medicine 2024 22:117
  48. Type 2 diabetes (T2D) is associated with an increased risk of premature death. Whether multifactorial risk factor modification could attenuate T2D-related excess risk of death is unclear. We aimed to examine t...

    Authors: Bin Wang, Yanqi Fu, Xiao Tan, Ningjian Wang, Lu Qi and Yingli Lu
    Citation: BMC Medicine 2024 22:114
  49. In post-stroke atrial fibrillation (AF) patients who have indications for both oral anticoagulant (OAC) and antiplatelet agent (AP), e.g., those with carotid artery stenosis, there is debate over the best anti...

    Authors: Chuan-Tsai Tsai, Yi-Hsin Chan, Jo-Nan Liao, Tzeng-Ji Chen, Gregory Y. H. Lip, Shih-Ann Chen and Tze-Fan Chao
    Citation: BMC Medicine 2024 22:113