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  1. Alcohol consumption is an important risk factor for hepatic neoplastic and non-neoplastic diseases. Questions remain, however, about the relevance to disease risk of drinking patterns and alcohol tolerability,...

    Authors: Pek Kei Im, Iona Y. Millwood, Christiana Kartsonaki, Yu Guo, Yiping Chen, Iain Turnbull, Canqing Yu, Huaidong Du, Pei Pei, Jun Lv, Robin G. Walters, Liming Li, Ling Yang and Zhengming Chen

    Citation: BMC Medicine 2021 19:216

    Content type: Research article

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  2. Studies on allergy-related diseases in relation to abdominal pain-related functional gastrointestinal disorders (AP-FGIDs) in children are few and results are contradictory. We examined the associations betwee...

    Authors: Jessica Sjölund, Inger Kull, Anna Bergström, Jacob Järås, Jonas F. Ludvigsson, Hans Törnblom, Magnus Simrén and Ola Olén

    Citation: BMC Medicine 2021 19:214

    Content type: Research article

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  3. Significant improvements in mortality among patients with non-small cell lung cancer (NSCLC) in the USA over the past two decades have been reported based on Surveillance, Epidemiology, and End Results (SEER) ...

    Authors: Sreeram Ramagopalan, Thomas P. Leahy, Joshua Ray, Samantha Wilkinson, Cormac Sammon and Vivek Subbiah

    Citation: BMC Medicine 2021 19:209

    Content type: Research article

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  4. ROS1-rearranged lung cancers benefit from first-line crizotinib therapy; however, clinical and molecular factors that could affect crizotinib efficacy in ROS1-rearranged lung cancers are not yet well-elucidated. ...

    Authors: Yongchang Zhang, Xiangyu Zhang, Ruiguang Zhang, Qinqin Xu, Haiyan Yang, Analyn Lizaso, Chunwei Xu, Jun Liu, Wenxian Wang, Sai-Hong Ignatius Ou, Jiexia Zhang, Zhengbo Song and Nong Yang

    Citation: BMC Medicine 2021 19:206

    Content type: Research article

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  5. Schools were closed in England on 4 January 2021 as part of increased national restrictions to curb transmission of SARS-CoV-2. The UK government reopened schools on 8 March. Although there was evidence of low...

    Authors: James D. Munday, Christopher I. Jarvis, Amy Gimma, Kerry L. M. Wong, Kevin van Zandvoort, Sebastian Funk and W. John Edmunds

    Citation: BMC Medicine 2021 19:233

    Content type: Research article

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  6. Genetic, lifestyle, and environmental factors can lead to perturbations in circulating lipid levels and increase the risk of cardiovascular and metabolic diseases. However, how changes in individual lipid spec...

    Authors: Eric L. Harshfield, Eric B. Fauman, David Stacey, Dirk S. Paul, Daniel Ziemek, Rachel M. Y. Ong, John Danesh, Adam S. Butterworth, Asif Rasheed, Taniya Sattar, Zameer-ul-Asar, Imran Saleem, Zoubia Hina, Unzila Ishtiaq, Nadeem Qamar, Nadeem Hayat Mallick…

    Citation: BMC Medicine 2021 19:232

    Content type: Research article

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  7. Integration of health services might be an efficient strategy for managing multiple chronic conditions in sub-Saharan Africa, considering the scope of treatments and synergies in service delivery. Proven to pr...

    Authors: Tinevimbo Shiri, Josephine Birungi, Anupam V. Garrib, Sokoine L. Kivuyo, Ivan Namakoola, Janneth Mghamba, Joshua Musinguzi, Godfather Kimaro, Gerald Mutungi, Moffat J. Nyirenda, Joseph Okebe, Kaushik Ramaiya, M. Bachmann, Nelson K. Sewankambo, Sayoki Mfinanga, Shabbar Jaffar…

    Citation: BMC Medicine 2021 19:230

    Content type: Research article

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  8. Healthy individuals and patients with cancer who are carriers of germline pathogenic variants in the BRCA1/2 genes face multiple reproductive challenges that require appropriate counseling and specific expertise.

    Authors: Barbara Buonomo, Claudia Massarotti, Miriam Dellino, Paola Anserini, Alberta Ferrari, Maria Campanella, Mirosa Magnotti, Cristofaro De Stefano, Fedro Alessandro Peccatori and Matteo Lambertini

    Citation: BMC Medicine 2021 19:205

    Content type: Correspondence

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  9. The sustainable development goals aim to improve health for all by 2030. They incorporate ambitious goals regarding tuberculosis (TB), which may be a significant cause of disability, yet to be quantified. Ther...

    Authors: Kefyalew Addis Alene, Kinley Wangdi, Samantha Colquhoun, Kudakwashe Chani, Tauhid Islam, Kalpeshsinh Rahevar, Fukushi Morishita, Anthony Byrne, Justin Clark and Kerri Viney

    Citation: BMC Medicine 2021 19:203

    Content type: Research article

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  10. Disordered fetal adrenal steroidogenesis can cause marked clinical effects including virilization of female fetuses. In postnatal life, adrenal disorders can be life-threatening due to the risk of adrenal cris...

    Authors: Cecilie Melau, Malene Lundgaard Riis, John E. Nielsen, Signe Perlman, Lene Lundvall, Lea Langhoff Thuesen, Kristine Juul Hare, Mette Schou Hammerum, Rod T. Mitchell, Hanne Frederiksen, Anders Juul and Anne Jørgensen

    Citation: BMC Medicine 2021 19:204

    Content type: Research article

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  11. Circumpapillary retinal nerve fiber layer thickness (cpRNFLT) as assessed by spectral domain optical coherence tomography (SD-OCT) is a new technique used for the detection and evaluation of glaucoma and other...

    Authors: Franziska G. Rauscher, Mengyu Wang, Mike Francke, Kerstin Wirkner, Anke Tönjes, Christoph Engel, Joachim Thiery, Peter Stenvinkel, Michael Stumvoll, Markus Loeffler, Tobias Elze and Thomas Ebert

    Citation: BMC Medicine 2021 19:202

    Content type: Research article

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  12. Renal neoplasms encompass a variety of malignant and benign tumors, including many with shared characteristics. The diagnosis of these renal neoplasms remains challenging with currently available tools. In thi...

    Authors: Susana Jorge, José L. Capelo, William LaFramboise, Swati Satturwar, Dimitrios Korentzelos, Sheldon Bastacky, Gabriela Quiroga-Garza, Rajiv Dhir, Jacek R. Wiśniewski, Carlos Lodeiro and Hugo M. Santos

    Citation: BMC Medicine 2021 19:196

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2021 19:221

  13. Current methods for cervical cancer screening result in an increased number of referrals and unnecessary diagnostic procedures. This study aimed to develop and evaluate a more accurate model for cervical cance...

    Authors: Zeni Wu, Tingyuan Li, Yongli Han, Mingyue Jiang, Yanqin Yu, Huifang Xu, Lulu Yu, Jianfeng Cui, Bin Liu, Feng Chen, Jian Yin, Xun Zhang, Qinjing Pan, Youlin Qiao and Wen Chen

    Citation: BMC Medicine 2021 19:197

    Content type: Research article

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  14. Bacterial vaginosis (BV) is the most common vaginal dysbiosis to affect women globally, yet an unacceptably high proportion of women experience BV recurrence within 6 months of recommended antibiotic therapy. ...

    Authors: Lenka A. Vodstrcil, Christina A. Muzny, Erica L. Plummer, Jack D. Sobel and Catriona S. Bradshaw

    Citation: BMC Medicine 2021 19:194

    Content type: Review

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  15. Triple-negative breast cancer (TNBC) is a clinically aggressive disease with abundant variants that cause homologous recombination repair deficiency (HRD). Whether TNBC patients with HRD are sensitive to anthr...

    Authors: Gaoming Liao, Zedong Jiang, Yiran Yang, Cong Zhang, Meiting Jiang, Jiali Zhu, Liwen Xu, Aimin Xie, Min Yan, Yunpeng Zhang, Yun Xiao and Xia Li

    Citation: BMC Medicine 2021 19:190

    Content type: Research article

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  16. Anticoagulation for stroke prevention in atrial fibrillation (AF) has, historically, been under-used in older people. The aim of this study was to investigate prescribing of oral anticoagulants (OACs) for peop...

    Authors: Anneka Mitchell, Julia Snowball, Tomas J. Welsh, Margaret C. Watson and Anita McGrogan

    Citation: BMC Medicine 2021 19:189

    Content type: Research article

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  17. The literature paints a complex picture of the association between mortality risk and ICU strain.

    Authors: Harrison Wilde, Thomas Mellan, Iwona Hawryluk, John M. Dennis, Spiros Denaxas, Christina Pagel, Andrew Duncan, Samir Bhatt, Seth Flaxman, Bilal A. Mateen and Sebastian J. Vollmer

    Citation: BMC Medicine 2021 19:213

    Content type: Research article

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  18. This study applies an umbrella review approach to summarise the global evidence on the risk of severe COVID-19 outcomes in patients with pre-existing health conditions.

    Authors: Marina Treskova-Schwarzbach, Laura Haas, Sarah Reda, Antonia Pilic, Anna Borodova, Kasra Karimi, Judith Koch, Teresa Nygren, Stefan Scholz, Viktoria Schönfeld, Sabine Vygen-Bonnet, Ole Wichmann and Thomas Harder

    Citation: BMC Medicine 2021 19:212

    Content type: Research article

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  19. Emergence of more transmissible SARS-CoV-2 variants requires more efficient control measures to limit nosocomial transmission and maintain healthcare capacities during pandemic waves. Yet the relative importan...

    Authors: Thi Mui Pham, Hannan Tahir, Janneke H. H. M. van de Wijgert, Bastiaan R. Van der Roest, Pauline Ellerbroek, Marc J. M. Bonten, Martin C. J. Bootsma and Mirjam E. Kretzschmar

    Citation: BMC Medicine 2021 19:211

    Content type: Research article

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  20. Impaired orthostatic blood pressure response and syncope confer a high risk of falls and trauma. The relationship between a history of unexplained syncope and orthostatic hypotension (OH) with subsequent fract...

    Authors: Madeleine Johansson, Cecilia Rogmark, Richard Sutton, Artur Fedorowski and Viktor Hamrefors

    Citation: BMC Medicine 2021 19:188

    Content type: Research article

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  21. The optimal posttreatment surveillance strategy for nasopharyngeal carcinoma (NPC) remains unclear. Circulating cell-free Epstein-Barr virus (cfEBV) DNA has been recognized as a promising biomarker to facilita...

    Authors: Chen-Fei Wu, Li Lin, Yan-Ping Mao, Bin Deng, Jia-Wei Lv, Wei-Hong Zheng, Dan-Wan Wen, Jia Kou, Fo-Ping Chen, Xing-Li Yang, Si-Si Xu, Jun Ma, Guan-Qun Zhou and Ying Sun

    Citation: BMC Medicine 2021 19:193

    Content type: Research article

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  22. Schizophrenia and bipolar disorder are severe mental illnesses which are highly prevalent worldwide. Risperidone and Paliperidone are treatments for either illnesses, but their efficacy compared to other antip...

    Authors: Alexander Hodkinson, Carl Heneghan, Kamal R. Mahtani, Evangelos Kontopantelis and Maria Panagioti

    Citation: BMC Medicine 2021 19:195

    Content type: Research article

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  23. The pathogenesis of malaria in pregnancy (MiP) involves accumulation of P. falciparum-infected red blood cells (pRBCs) in the placenta, contributing to poor pregnancy outcomes. Parasite accumulation is primarily ...

    Authors: D. Herbert Opi, Michelle J. Boyle, Alistair R. D. McLean, Linda Reiling, Jo-Anne Chan, Danielle I. Stanisic, Alice Ura, Ivo Mueller, Freya J. I. Fowkes, Stephen J. Rogerson and James G. Beeson

    Citation: BMC Medicine 2021 19:201

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2021 19:231

  24. Coronavirus SARS-CoV-2, the causative agent of COVID-19, has caused a still evolving global pandemic. Given the worldwide vaccination campaign, the understanding of the vaccine-induced versus COVID-19-induced ...

    Authors: Ioannis P. Trougakos, Evangelos Terpos, Christina Zirou, Aimilia D. Sklirou, Filia Apostolakou, Sentiljana Gumeni, Ioanna Charitaki, Eleni-Dimitra Papanagnou, Tina Bagratuni, Christine-Ivy Liacos, Andreas Scorilas, Eleni Korompoki, Ioannis Papassotiriou, Efstathios Kastritis and Meletios A. Dimopoulos

    Citation: BMC Medicine 2021 19:208

    Content type: Research article

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  25. Although the pathophysiology of cognitive decline is multifactorial, and modifiable by lifestyle, the evidence for the role of diet on cognitive function is still accumulating, particularly the potentially pre...

    Authors: Amy Jennings, Claire J. Steves, Alexander Macgregor, Tim Spector and Aedín Cassidy

    Citation: BMC Medicine 2021 19:185

    Content type: Research article

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  26. Authors: Terence J. Quin, Jennifer K. Burton, Ben Carter, Nicola Cooper, Kerry Dwan, Ryan Field, Suzane C. Freeman, Claudia Gue, Ping-Hsuan Hsieh, Kris McGill, Clareece R. Nevill, Dikshyanta Rana, Alex Sutton, Martin Taylor Rowan and Yiqiao Xin

    Citation: BMC Medicine 2021 19:207

    Content type: Correction

    Published on:

    The original article was published in BMC Medicine 2021 19:46

  27. Type 2 diabetes (T2D) is common and increasing in prevalence. It is possible to prevent or delay T2D using lifestyle intervention programmes. Entry to these programmes is usually determined by a measure of gly...

    Authors: Lauren R. Rodgers, Anita V. Hill, John M. Dennis, Zoe Craig, Benedict May, Andrew T. Hattersley, Timothy J. McDonald, Rob C. Andrews, Angus Jones and Beverley M. Shields

    Citation: BMC Medicine 2021 19:184

    Content type: Research article

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  28. The purpose of this trial was to test if the Norfolk Diabetes Prevention Study (NDPS) lifestyle intervention, recently shown to reduce the incidence of type 2 diabetes in high-risk groups, also improved glycae...

    Authors: Michael Sampson, Allan Clark, Max Bachmann, Nikki Garner, Lisa Irvine, Amanda Howe, Colin Greaves, Sara Auckland, Jane Smith, Jeremy Turner, Dave Rea, Gerry Rayman, Ketan Dhatariya, W. Garry John, Garry Barton, Rebecca Usher…

    Citation: BMC Medicine 2021 19:183

    Content type: Research article

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  29. The use of proactive genetic screening for disease prevention and early detection is not yet widespread. Professional practice guidelines from the American College of Medical Genetics and Genomics (ACMG) have ...

    Authors: Eden V. Haverfield, Edward D. Esplin, Sienna J. Aguilar, Kathryn E. Hatchell, Kelly E. Ormond, Andrea Hanson-Kahn, Paldeep S. Atwal, Sarah Macklin-Mantia, Stephanie Hines, Caron W.-M. Sak, Steven Tucker, Steven B. Bleyl, Peter J. Hulick, Ora K. Gordon, Lea Velsher, Jessica Y. J. Gu…

    Citation: BMC Medicine 2021 19:199

    Content type: Research article

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  30. Preventing unintended pregnancies is paramount for women living with HIV (WLHIV). Previous studies have suggested that efavirenz-containing antiretroviral therapy (ART) reduces contraceptive effectiveness of i...

    Authors: Rena C. Patel, Gustavo Amorim, Beatrice Jakait, Bryan E. Shepherd, A. Rain Mocello, Beverly Musick, Caitlin Bernard, Maricianah Onono, Elizabeth A. Bukusi, Kara Wools-Kaloustian, Craig R. Cohen and Constantin T. Yiannoutsos

    Citation: BMC Medicine 2021 19:178

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2021 19:192

  31. The COVID-19 pandemic has disrupted the delivery of immunisation services globally. Many countries have postponed vaccination campaigns out of concern about infection risks to the staff delivering vaccination,...

    Authors: Simon R. Procter, Kaja Abbas, Stefan Flasche, Ulla Griffiths, Brittany Hagedorn, Kathleen M. O’Reilly and Mark Jit

    Citation: BMC Medicine 2021 19:198

    Content type: Research article

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  32. Over 200 schizophrenia risk loci have been identified by genome-wide association studies (GWASs). However, the majority of risk loci were identified in populations of European ancestry (EUR), potentially missi...

    Authors: Jiewei Liu, Shiwu Li, Xiaoyan Li, Wenqiang Li, Yongfeng Yang, Suqin Guo, Luxian Lv, Xiao Xiao, Yong-Gang Yao, Fanglin Guan, Ming Li and Xiong-Jian Luo

    Citation: BMC Medicine 2021 19:177

    Content type: Research article

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  33. Globally, Haemophilus influenzae type b (Hib) vaccine has substantially reduced the burden of Hib invasive disease. However, China remains the only country not to include Hib vaccine into its national immunizatio...

    Authors: Haijun Zhang, Cristina Garcia, Wenzhou Yu, Maria Deloria Knoll, Xiaozhen Lai, Tingting Xu, Rize Jing, Ying Qin, Zundong Yin, Brian Wahl and Hai Fang

    Citation: BMC Medicine 2021 19:181

    Content type: Research article

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  34. Patients with atrial fibrillation (AF) complicated by heart failure (HF) have a poor prognosis. We investigated whether long term loop-diuretic therapy in patients with AF and no known diagnosis of HF, as a po...

    Authors: Rosita Zakeri, Ann D. Morgan, Varun Sundaram, Chloe Bloom, John G. F. Cleland and Jennifer K. Quint

    Citation: BMC Medicine 2021 19:179

    Content type: Research article

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  35. Knowledge about the 1-year outcome of COVID-19 is limited. The aim of this study was to follow-up and evaluate lung abnormalities on serial computed tomography (CT) scans in patients with COVID-19 after hospit...

    Authors: Yanfei Chen, Cheng Ding, Ling Yu, Wanru Guo, Xuewen Feng, Liang Yu, Junwei Su, Ting Xu, Cheng Ren, Ding Shi, Wenrui Wu, Ping Yi, Jun Liu, Jingjing Tao, Guanjing Lang, Yongtao Li…

    Citation: BMC Medicine 2021 19:191

    Content type: Research article

    Published on:

    The Commentary to this article has been published in BMC Medicine 2021 19:200

  36. Adverse childhood experiences (ACEs) are negatively associated with a range of child health outcomes. In this study, we explored associations between five individual ACEs and child mental health diagnoses or s...

    Authors: Emily Lowthian, Rebecca Anthony, Annette Evans, Rhian Daniel, Sara Long, Amrita Bandyopadhyay, Ann John, Mark A. Bellis and Shantini Paranjothy

    Citation: BMC Medicine 2021 19:172

    Content type: Research article

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  37. The high degree of heterogeneity brought great challenges to the diagnosis and treatment of acute myeloid leukemia (AML). Although several different AML prognostic scoring models have been proposed to assess t...

    Authors: Tiansheng Zeng, Longzhen Cui, Wenhui Huang, Yan Liu, Chaozeng Si, Tingting Qian, Cong Deng and Lin Fu

    Citation: BMC Medicine 2021 19:176

    Content type: Research article

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  38. The differential effect of pre-pregnancy low BMI on macrosomia has not been fully addressed. Herein, we conducted a city-wide population-based cohort study to illuminate the association between pre-pregnancy l...

    Authors: Guoju Li, Yuhan Xing, Guolan Wang, Jun Zhang, Qin Wu, Wei Ni, Na Jiao, Wenjing Chen, Qing Liu, Li Gao, Zhenhong Zhang, Yao Wang and Quansheng Xing

    Citation: BMC Medicine 2021 19:175

    Content type: Research article

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  39. The risk for several common cancers is influenced by the transcriptomic landscape of the respective tissue-of-origin. Vitamin D influences in vitro gene expression and cancer cell growth. We sought to determin...

    Authors: P. G. Vaughan-Shaw, G. Grimes, J. P. Blackmur, M. Timofeeva, M. Walker, L. Y. Ooi, Victoria Svinti, Kevin Donnelly, F. V. N. Din, S. M. Farrington and M. G. Dunlop

    Citation: BMC Medicine 2021 19:174

    Content type: Research article

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