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  1. Content type: Research article

    Long waiting times are associated with public community outpatient health services. This trial aimed to determine if a new model of care based on evidence-based strategies that improved patient flow in two sma...

    Authors: Katherine E. Harding, Sandra G. Leggat, Jennifer J. Watts, Bridie Kent, Luke Prendergast, Michelle Kotis, Mary O’Reilly, Leila Karimi, Annie K. Lewis, David A. Snowdon and Nicholas F. Taylor

    Citation: BMC Medicine 2018 16:182

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  2. Content type: Research article

    A sequence of annual measles epidemics has been observed from January 2013 to April 2017 in the South West Shoa Zone of the Oromia Region, Ethiopia. We aimed at estimating the burden of disease in the affected...

    Authors: Piero Poletti, Stefano Parlamento, Tafarraa Fayyisaa, Rattaa Feyyiss, Marta Lusiani, Ademe Tsegaye, Giulia Segafredo, Giovanni Putoto, Fabio Manenti and Stefano Merler

    Citation: BMC Medicine 2018 16:177

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  3. Content type: Opinion

    Recent global progress in scaling up malaria control interventions has revived the goal of complete elimination in many countries. Decreasing transmission intensity generally leads to increasingly patchy spati...

    Authors: Amy Wesolowski, Aimee R Taylor, Hsiao-Han Chang, Robert Verity, Sofonias Tessema, Jeffrey A Bailey, T Alex Perkins, Daniel E Neafsey, Bryan Greenhouse and Caroline O Buckee

    Citation: BMC Medicine 2018 16:190

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  4. Content type: Research article

    Local mosquito-borne Zika virus (ZIKV) transmission has been reported in two counties in the contiguous United States (US), prompting the issuance of travel, prevention, and testing guidance across the contigu...

    Authors: Kaiyuan Sun, Qian Zhang, Ana Pastore-Piontti, Matteo Chinazzi, Dina Mistry, Natalie E Dean, Diana Patricia Rojas, Stefano Merler, Piero Poletti, Luca Rossi, M Elizabeth Halloran, Ira M Longini Jr and Alessandro Vespignani

    Citation: BMC Medicine 2018 16:195

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  5. Content type: Research article

    Tuberculosis (TB) transmission often occurs within a household or community, leading to heterogeneous spatial patterns. However, apparent spatial clustering of TB could reflect ongoing transmission or co-locat...

    Authors: Debebe Shaweno, Malancha Karmakar, Kefyalew Addis Alene, Romain Ragonnet, Archie CA Clements, James M. Trauer, Justin T. Denholm and Emma S. McBryde

    Citation: BMC Medicine 2018 16:193

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  7. Content type: Research article

    In the REMoxTB study of 4-month treatment-shortening regimens containing moxifloxacin compared to the standard 6-month regimen for tuberculosis, the proportion of unfavourable outcomes for women was similar in...

    Authors: M. E. Murphy, G. H. Wills, S. Murthy, C. Louw, A. L. C. Bateson, R. D. Hunt, T. D. McHugh, A. J. Nunn, S. K. Meredith, C. M. Mendel, M. Spigelman, A. M. Crook and S. H. Gillespie

    Citation: BMC Medicine 2018 16:189

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  9. Content type: Research article

    We aimed to determine the best study designs for assessing interventions to improve the peer review process according to experts’ opinions. Furthermore, for interventions previously evaluated, we determined wh...

    Authors: Amytis Heim, Philippe Ravaud, Gabriel Baron and Isabelle Boutron

    Citation: BMC Medicine 2018 16:191

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  10. Content type: Research article

    Clinical decision rules (CDRs) aid in the management of children with traumatic brain injury (TBI). Recently, the Scandinavian Neurotrauma Committee (SNC) has published practical, evidence-based guidelines for...

    Authors: Johan Undén, Stuart R. Dalziel, Meredith L. Borland, Natalie Phillips, Amit Kochar, Mark D. Lyttle, Silvia Bressan, John A. Cheek, Jocelyn Neutze, Susan Donath, Stephen Hearps, Ed Oakley, Sarah Dalton, Yuri Gilhotra and Franz E. Babl

    Citation: BMC Medicine 2018 16:176

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  11. Content type: Research article

    Ensuring effective identification and management of sepsis is a healthcare priority in many countries. Recommendations for sepsis management in primary care have been produced, but in complex healthcare system...

    Authors: Duncan McNab, John Freestone, Chris Black, Andrew Carson-Stevens and Paul Bowie

    Citation: BMC Medicine 2018 16:174

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  12. Content type: Research article

    The focus of this study is to identify particular microRNA (miRNA) signatures in exosomes derived from plasma of 435 human epidermal growth factor receptor 2 (HER2)-positive and triple-negative (TN) subtypes o...

    Authors: Ines Stevic, Volkmar Müller, Karsten Weber, Peter A. Fasching, Thomas Karn, Frederic Marmé, Christian Schem, Elmar Stickeler, Carsten Denkert, Marion van Mackelenbergh, Christoph Salat, Andreas Schneeweiss, Klaus Pantel, Sibylle Loibl, Michael Untch and Heidi Schwarzenbach

    Citation: BMC Medicine 2018 16:179

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  13. Content type: Debate

    Direct-acting antivirals (DAAs) have dramatically changed the landscape of hepatitis C treatment and prevention. The World Health Organization has called for the elimination of hepatitis C as a public health t...

    Authors: Caitlin H. Douglass, Alisa Pedrana, Jeffrey V. Lazarus, Ellen F. M. ‘t Hoen, Radi Hammad, Ricardo Baptista Leite, Andrew Hill and Margaret Hellard

    Citation: BMC Medicine 2018 16:175

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  14. Content type: Research article

    The continuing morbidity and mortality associated with infection with malaria parasites highlights the urgent need for a vaccine. The efficacy of sub-unit vaccines tested in clinical trials in malaria-endemic ...

    Authors: Danielle I. Stanisic, James Fink, Johanna Mayer, Sarah Coghill, Letitia Gore, Xue Q. Liu, Ibrahim El-Deeb, Ingrid B. Rodriguez, Jessica Powell, Nicole M. Willemsen, Sai Lata De, Mei-Fong Ho, Stephen L. Hoffman, John Gerrard and Michael F. Good

    Citation: BMC Medicine 2018 16:184

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  15. Content type: Commentary

    Emergency hospital admissions are common, with several interventions having been developed to reduce their rates. Bobrovitz et al. summarized the available body of evidence regarding pharmacologic therapies ai...

    Authors: Michael R. Gionfriddo

    Citation: BMC Medicine 2018 16:169

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    The original article was published in BMC Medicine 2018 16:115

  16. Content type: Research article

    Chronic obstructive pulmonary disease (COPD) is often accompanied by multiple comorbidities, which are associated with an increased risk of exacerbation, a poor health-related quality of life, and high mortali...

    Authors: Hyun Lee, Sun Hye Shin, Seonhye Gu, Di Zhao, Danbee Kang, Yeong Rae Joi, Gee Young Suh, Roberto Pastor-Barriuso, Eliseo Guallar, Juhee Cho and Hye Yun Park

    Citation: BMC Medicine 2018 16:178

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  17. Content type: Research article

    Zika virus (ZIKV) emerged in Latin America and the Caribbean (LAC) region in 2013, with serious implications for population health in the region. In 2016, the World Health Organization declared the ZIKV outbre...

    Authors: Kathleen M. O’Reilly, Rachel Lowe, W. John Edmunds, Philippe Mayaud, Adam Kucharski, Rosalind M. Eggo, Sebastian Funk, Deepit Bhatia, Kamran Khan, Moritz U. G. Kraemer, Annelies Wilder-Smith, Laura C. Rodrigues, Patricia Brasil, Eduardo Massad, Thomas Jaenisch, Simon Cauchemez…

    Citation: BMC Medicine 2018 16:180

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  19. Content type: Research article

    Humanity has become largely dependent on artemisinin derivatives for both the treatment and control of malaria, with few alternatives available. A Plasmodium falciparum phenotype with delayed parasite clearance d...

    Authors: Rajeev K. Tyagi, Patrick J. Gleeson, Ludovic Arnold, Rachida Tahar, Eric Prieur, Laurent Decosterd, Jean-Louis Pérignon, Piero Olliaro and Pierre Druilhe

    Citation: BMC Medicine 2018 16:181

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  21. Content type: Research article

    Refugees are generally considered a vulnerable population, with refugee children (newborn and young children) being particularly so. Access to healthcare for this population remains a challenge. The main purpo...

    Authors: Anna Meyer-Weitz, Kwaku Oppong Asante and Bukenge J. Lukobeka

    Citation: BMC Medicine 2018 16:163

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  22. Content type: Research article

    Social and cultural disparities in infectious disease burden are caused by systematic differences between communities. Some differences have a direct and proportional impact on disease burden, such as health-s...

    Authors: James D. Munday, Albert Jan van Hoek, W. John Edmunds and Katherine E. Atkins

    Citation: BMC Medicine 2018 16:162

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  23. Content type: Research article

    Chronic diseases and musculoskeletal conditions have a significant global burden and frequently co-occur. Musculoskeletal conditions may contribute to the development of chronic disease; however, this has not ...

    Authors: Amanda Williams, Steven J. Kamper, John H. Wiggers, Kate M. O’Brien, Hopin Lee, Luke Wolfenden, Sze Lin Yoong, Emma Robson, James H. McAuley, Jan Hartvigsen and Christopher M. Williams

    Citation: BMC Medicine 2018 16:167

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  24. Content type: Research article

    Various individual biomarkers of inflammation and micronutrient status, often correlated with each other, are associated with adverse treatment outcomes in human immunodeficiency virus (HIV)-infected adults. T...

    Authors: Rupak Shivakoti, Nikhil Gupte, Srikanth Tripathy, Selvamuthu Poongulali, Cecilia Kanyama, Sima Berendes, Sandra W. Cardoso, Breno R. Santos, Alberto La Rosa, Noluthando Mwelase, Sandy Pillay, Wadzanai Samaneka, Cynthia Riviere, Patcharaphan Sugandhavesa, Robert C. Bollinger, Ashwin Balagopal…

    Citation: BMC Medicine 2018 16:161

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  26. Content type: Research article

    Low birth weight (LBW) and preterm birth (PTB) are major contributors to infant mortality and chronic childhood morbidity. Understanding factors that contribute to or protect against these adverse birth outcom...

    Authors: Freya J. I. Fowkes, Kerryn A. Moore, D. Herbert Opi, Julie A. Simpson, Freya Langham, Danielle I. Stanisic, Alice Ura, Christopher L. King, Peter M. Siba, Ivo Mueller, Stephen J. Rogerson and James G. Beeson

    Citation: BMC Medicine 2018 16:156

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  27. Content type: Opinion

    The choice of the most appropriate antithrombotic regimen that balances ischemic and bleeding risks was addressed by the August 2017 European Society of Cardiologists (ESC)/European Association for Cardio-Thor...

    Authors: Adrian Covic, Simonetta Genovesi, Patrick Rossignol, Philip A. Kalra, Alberto Ortiz, Maciej Banach and Alexandru Burlacu

    Citation: BMC Medicine 2018 16:158

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  28. Content type: Commentary

    A first UN General Assembly high-level meeting on the fight against tuberculosis (TB) will take place on September 26, 2018. It offers the opportunity to forge new concrete commitments and action needed to fin...

    Authors: Diana Weil, Kristijan Marinkovic and Tereza Kasaeva

    Citation: BMC Medicine 2018 16:172

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  29. Content type: Research article

    Despite increasing numbers of refugee women-at-risk being resettled and their potential vulnerability, there exists no empirical research into the psychiatric health of this unique subgroup with which to guide...

    Authors: Robert D. Schweitzer, Lyn Vromans, Mark Brough, Mary Asic-Kobe, Ignacio Correa-Velez, Kate Murray and Caroline Lenette

    Citation: BMC Medicine 2018 16:149

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  30. Content type: Research article

    Universal health coverage (UHC) aims to improve child health through preventive primary care and vaccine coverage. Yet, in many developed countries with UHC, unplanned and ambulatory care sensitive (ACS) hospi...

    Authors: Elizabeth Cecil, Alex Bottle, Richard Ma, Dougal S. Hargreaves, Ingrid Wolfe, Arch G. Mainous III and Sonia Saxena

    Citation: BMC Medicine 2018 16:151

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  31. Content type: Research article

    Despite the biological plausibility of hotspots fueling malaria transmission, the evidence to support this concept has been mixed. If transmission spreads from high burden to low burden households in a consist...

    Authors: Gillian H. Stresman, Julia Mwesigwa, Jane Achan, Emanuele Giorgi, Archibald Worwui, Musa Jawara, Gian Luca Di Tanna, Teun Bousema, Jean-Pierre Van Geertruyden, Chris Drakeley and Umberto D’Alessandro

    Citation: BMC Medicine 2018 16:160

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  32. Content type: Research article

    In August 2014, the Islamic State of Iraq and Syria (ISIS), a terrorist organization, attacked the Yazidi’s ancestral homeland in northwestern Iraq. Among other atrocities, they abducted thousands of women and...

    Authors: Hawkar Ibrahim, Verena Ertl, Claudia Catani, Azad Ali Ismail and Frank Neuner

    Citation: BMC Medicine 2018 16:154

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  33. Content type: Research article

    Non-alcoholic steatohepatitis (NASH) is among the leading causes of liver disease worldwide. It is increasingly recognized that the phenotype of NASH may involve a number of different pathways, of which each c...

    Authors: Zobair M. Younossi, Azza Karrar, Mariaelena Pierobon, Aybike Birerdinc, Maria Stepanova, Dinan Abdelatif, Zahra Younoszai, Thomas Jeffers, Sean Felix, Kianoush Jeiran, Alex Hodge, Weidong Zhou, Fanny Monge, Lakshmi Alaparthi, Vikas Chandhoke, Zachary D. Goodman…

    Citation: BMC Medicine 2018 16:170

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  34. Content type: Research article

    The heterogeneity of symptoms across dementia subtypes has important implications for clinical practice and dementia research. Variation in subtypes and associated symptoms may influence the capability to live...

    Authors: Yu-Tzu Wu, Linda Clare, John V. Hindle, Sharon M. Nelis, Anthony Martyr and Fiona E. Matthews

    Citation: BMC Medicine 2018 16:140

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  35. Content type: Correspondence

    Since 2013, a biennial rotavirus pattern has emerged in the Netherlands with alternating high and low endemic years and a nearly 50% reduction in rotavirus hospitalization rates overall, while infant rotavirus...

    Authors: P. Bruijning-Verhagen, J. A. P. van Dongen, J. D. M. Verberk, R. Pijnacker, R. D. van Gaalen, D. Klinkenberg, H. E. de Melker and M.-J. J. Mangen

    Citation: BMC Medicine 2018 16:168

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  36. Content type: Research article

    The science of complex systems has been proposed as a way of understanding health services and the demand for them, but there is little quantitative evidence to support this. We analysed patterns of healthcare...

    Authors: Christopher Burton, Alison Elliott, Amanda Cochran and Tom Love

    Citation: BMC Medicine 2018 16:138

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  37. Content type: Research article

    Brazil has high burdens of tuberculosis (TB) and HIV, as previously estimated for the 26 states and the Federal District, as well as high levels of inequality in social and health indicators. We improved the g...

    Authors: Jennifer M. Ross, Nathaniel J. Henry, Laura A. Dwyer-Lindgren, Andrea de Paula Lobo, Fatima Marinho de Souza, Molly H. Biehl, Sarah E. Ray, Robert C. Reiner Jr, Rebecca W. Stubbs, Kirsten E. Wiens, Lucas Earl, Michael J. Kutz, Natalia V. Bhattacharjee, Hmwe H. Kyu, Mohsen Naghavi and Simon I. Hay

    Citation: BMC Medicine 2018 16:144

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  38. Content type: Research article

    There is increasing interest in estimating the broader benefits of public health interventions beyond those captured in traditional cost-utility analyses. Cost-benefit analysis (CBA) in principle offers a way ...

    Authors: Minah Park, Mark Jit and Joseph T. Wu

    Citation: BMC Medicine 2018 16:139

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  39. Content type: Research article

    High-income countries like Australia play a vital role in resettling refugees from around the world, half of whom are children and adolescents. Informed by an ecological framework, this study examined the post...

    Authors: Winnie Lau, Derrick Silove, Ben Edwards, David Forbes, Richard Bryant, Alexander McFarlane, Dusan Hadzi-Pavlovic, Zachary Steel, Angela Nickerson, Miranda Van Hooff, Kim Felmingham, Sean Cowlishaw, Nathan Alkemade, Dzenana Kartal and Meaghan O’Donnell

    Citation: BMC Medicine 2018 16:157

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    The Commentary to this article has been published in BMC Medicine 2018 16:164

  40. Content type: Commentary

    The ever-increasing number of reasons forcing people to flee from their homes to new, safer places either within their countries of origin, into neighbouring countries or across continental, conversant and cul...

    Authors: Mina Fazel

    Citation: BMC Medicine 2018 16:164

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    The original article was published in BMC Medicine 2018 16:157

  41. Content type: Research article

    We have previously conducted computer-based tournaments to compare the yield of alternative approaches to deploying mobile HIV testing services in settings where the prevalence of undetected infection may be c...

    Authors: Gregg S. Gonsalves, J. Tyler Copple, Tyler Johnson, A. David Paltiel and Joshua L. Warren

    Citation: BMC Medicine 2018 16:155

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  42. Content type: Research article

    The association between Institute of Medicine (IOM) guidelines and pregnancy outcomes across ethnicities is uncertain. We evaluated the associations of gestational weight gain (GWG) outside 2009 IOM guidelines...

    Authors: Rebecca F. Goldstein, Sally K. Abell, Sanjeeva Ranasinha, Marie L. Misso, Jacqueline A. Boyle, Cheryce L. Harrison, Mary Helen Black, Nan Li, Gang Hu, Francesco Corrado, Hanne Hegaard, Young Ju Kim, Margaretha Haugen, Won O. Song, Min Hyoung Kim, Annick Bogaerts…

    Citation: BMC Medicine 2018 16:153

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  43. Content type: Research article

    Mathematical models of transmission dynamics are routinely fitted to epidemiological time series, which must inevitably be aggregated at some spatial scale. Weekly case reports of chikungunya have been made av...

    Authors: Sean M. Moore, Quirine A. ten Bosch, Amir S. Siraj, K. James Soda, Guido España, Alfonso Campo, Sara Gómez, Daniela Salas, Benoit Raybaud, Edward Wenger, Philip Welkhoff and T. Alex Perkins

    Citation: BMC Medicine 2018 16:152

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  44. Content type: Research article

    Introduced in 2004, the United Kingdom’s (UK) Quality and Outcomes Framework (QOF) is the world’s largest primary-care pay-for-performance programme. Given some evidence of the benefits and the substantial cos...

    Authors: Ankur Pandya, Tim Doran, Jinyi Zhu, Simon Walker, Emily Arntson and Andrew M. Ryan

    Citation: BMC Medicine 2018 16:135

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  45. Content type: Research article

    The UK, like a number of other countries, has a refugee resettlement programme. External factors, such as higher prevalence of infectious diseases in the country of origin and circumstances of travel, are like...

    Authors: Alison F. Crawshaw, Manish Pareek, John Were, Steffen Schillinger, Olga Gorbacheva, Kolitha P. Wickramage, Sema Mandal, Valerie Delpech, Noel Gill, Hilary Kirkbride and Dominik Zenner

    Citation: BMC Medicine 2018 16:143

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  46. Content type: Debate

    Personalized, precision, P4, or stratified medicine is understood as a medical approach in which patients are stratified based on their disease subtype, risk, prognosis, or treatment response using specialized...

    Authors: Holger Fröhlich, Rudi Balling, Niko Beerenwinkel, Oliver Kohlbacher, Santosh Kumar, Thomas Lengauer, Marloes H. Maathuis, Yves Moreau, Susan A. Murphy, Teresa M. Przytycka, Michael Rebhan, Hannes Röst, Andreas Schuppert, Matthias Schwab, Rainer Spang, Daniel Stekhoven…

    Citation: BMC Medicine 2018 16:150

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  47. Content type: Correction

    The original article [1] contains errors in Table 1 affecting some of the presented oligonucleotide sequences and readthrough values in Table 1.

    Authors: I. Sermet-Gaudelus, M. Renouil, A. Fajac, L. Bidou, B. Parbaille, S. Pierrot, N. Davy, E. Bismuth, P. Reinert, G. Lenoir, J. F. Lesure, J. P. Rousset and A. Edelman

    Citation: BMC Medicine 2018 16:159

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    The original article was published in BMC Medicine 2007 5:5

  48. Content type: Commentary

    Non-alcoholic fatty liver disease (NAFLD) has emerged as a common cause of liver-related morbidity and mortality. Tackling this condition at a societal level will require a clear understanding of the burden of...

    Authors: Arun J. Sanyal

    Citation: BMC Medicine 2018 16:148

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    The original article was published in BMC Medicine 2018 16:130

  50. Content type: Commentary

    The question of whether depression is a causal factor in somatic diseases remains unanswered despite decades of research. In an extensive umbrella review of systematic reviews and meta-analyses, Machado et al. (B...

    Authors: Annelieke M. Roest and Peter de Jonge

    Citation: BMC Medicine 2018 16:147

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    The original article was published in BMC Medicine 2018 16:112

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