Articles

Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study

Circulating vitamin C concentrations have been associated with several cancers in observational studies, but little is known about the causal direction of the associations. This study aims to explore the poten...

Authors: Yuanqing Fu, Fengzhe Xu, Longda Jiang, Zelei Miao, Xinxiu Liang, Jian Yang, Susanna C. Larsson and Ju-Sheng Zheng

Temporal trends in cause-specific mortality among individuals with newly diagnosed atrial fibrillation in the Framingham Heart Study

All-cause mortality following atrial fibrillation (AF) has decreased over time. Data regarding temporal trends in causes of death among individuals with AF are scarce. The aim of our study was to analyze tempo...

Authors: Jelena Kornej, Qiuxi Huang, Sarah R. Preis, Steven A. Lubitz, Darae Ko, Joanne M. Murabito, Emelia J. Benjamin and Ludovic Trinquart

Evaluation of the safety profile of COVID-19 vaccines: a rapid review

The rapid process of research and development and lack of follow-up time post-vaccination aroused great public concern about the safety profile of COVID-19 vaccine candidates. To provide comprehensive overview...

Authors: Qianhui Wu, Matthew Z. Dudley, Xinghui Chen, Xufang Bai, Kaige Dong, Tingyu Zhuang, Daniel Salmon and Hongjie Yu

Parenteral artemisinins are associated with reduced mortality and neurologic deficits and improved long-term behavioral outcomes in children with severe malaria

In 2011, the World Health Organization recommended injectable artesunate as the first-line therapy for severe malaria (SM) due to its superiority in reducing mortality compared to quinine. There are limited da...

Authors: Andrea L. Conroy, Robert O. Opoka, Paul Bangirana, Ruth Namazzi, Allen E. Okullo, Michael K. Georgieff, Sarah Cusick, Richard Idro, John M. Ssenkusu and Chandy C. John

Association of alcohol consumption with morbidity and mortality in patients with cardiovascular disease: original data and meta-analysis of 48,423 men and women

Light-to-moderate alcohol consumption has been reported to be cardio-protective among apparently healthy individuals; however, it is unclear whether this association is also present in those with disease. To e...

Authors: Chengyi Ding, Dara O’Neill, Steven Bell, Emmanuel Stamatakis and Annie Britton

Humoral immune responses during SARS-CoV-2 mRNA vaccine administration in seropositive and seronegative individuals

The global pandemic of coronavirus disease 2019 (COVID-19) is caused by infection with the SARS-CoV-2 virus. Currently, there are three approved vaccines against SARS-CoV-2 in the USA, including two based on m...

Authors: Elizabeth Fraley, Cas LeMaster, Eric Geanes, Dithi Banerjee, Santosh Khanal, Elin Grundberg, Rangaraj Selvarangan and Todd Bradley

Variability of multi-omics profiles in a population-based child cohort

Multiple omics technologies are increasingly applied to detect early, subtle molecular responses to environmental stressors for future disease risk prevention. However, there is an urgent need for further eval...

Authors: Marta Gallego-Paüls, Carles Hernández-Ferrer, Mariona Bustamante, Xavier Basagaña, Jose Barrera-Gómez, Chung-Ho E. Lau, Alexandros P. Siskos, Marta Vives-Usano, Carlos Ruiz-Arenas, John Wright, Remy Slama, Barbara Heude, Maribel Casas, Regina Grazuleviciene, Leda Chatzi, Eva Borràs…

Identification of NOTCH4 mutation as a response biomarker for immune checkpoint inhibitor therapy

Immune checkpoint inhibitor (ICI) therapy elicits durable antitumor responses in patients with many types of cancer. Genomic mutations may be used to predict the clinical benefits of ICI therapy. NOTCH homolog...

Authors: Junyu Long, Dongxu Wang, Xu Yang, Anqiang Wang, Yu Lin, Mingjun Zheng, Haohai Zhang, Xinting Sang, Hanping Wang, Ke Hu and Haitao Zhao

Investigating causal relationships between exposome and human longevity: a Mendelian randomization analysis

Environmental factors are associated with human longevity, but their specificity and causality remain mostly unclear. By integrating the innovative “exposome” concept developed in the field of environmental ep...

Authors: Shu-Yi Huang, Yu-Xiang Yang, Shi-Dong Chen, Hong-Qi Li, Xue-Qing Zhang, Kevin Kuo, Lan Tan, Lei Feng, Qiang Dong, Can Zhang and Jin-Tai Yu

The economic value of changing mortality risk in low- and middle-income countries: a systematic breakdown by cause of death

We develop a framework for quantifying monetary values associated with changes in disease-specific mortality risk in low- and middle-income countries to help quantify trade-offs involved in investing in mortal...

Authors: Aayush Khadka and Stéphane Verguet

Human papillomavirus (HPV) testing for cervical cancer screening in a middle-income country: comment on a large real-world implementation study in China

Authors: Louise T. Thomsen and Susanne K. Kjær

Real-world effectiveness of primary screening with high-risk human papillomavirus testing in the cervical cancer screening programme in China: a nationwide, population-based study

Randomized controlled trials have shown a higher sensitivity and longer negative predictive value of high-risk human papillomavirus (HPV) testing than cytology for cervical cancer screening; however, little is...

Authors: Yanxia Zhao, Heling Bao, Lan Ma, Bo Song, Jiangli Di, Linhong Wang, Yanqiu Gao, Wenhui Ren, Shi Wang, Hai-Jun Wang and Jiuling Wu

Dynamic changes of functional fitness, antibodies to SARS-CoV-2 and immunological indicators within 1 year after discharge in Chinese health care workers with severe COVID-19: a cohort study

Few studies had described the health consequences of patients with coronavirus disease 2019 (COVID-19) especially in those with severe infections after discharge from hospital. Moreover, no research had report...

Authors: Lijuan Xiong, Qian Li, Xiongjing Cao, Huangguo Xiong, Ming Huang, Fengwen Yang, Qingquan Liu, Daquan Meng, Mei Zhou, Gang Wang, Jun Tong, Tengfei Chen, Yanzhao Zhang, Xinliang He, Yunzhou Fan, Yupeng Zhang…

Salivary metabolites associated with a 5-year tooth loss identified in a population-based setting

Periodontitis is among the most common chronic diseases worldwide, and it is one of the main reasons for tooth loss. Comprehensive profiling of the metabolite content of the saliva can enable the identificatio...

Authors: Leonie Andörfer, Birte Holtfreter, Stefan Weiss, Rutger Matthes, Vinay Pitchika, Carsten Oliver Schmidt, Stefanie Samietz, Gabi Kastenmüller, Matthias Nauck, Uwe Völker, Henry Völzke, Laszlo N. Csonka, Karsten Suhre, Maik Pietzner and Thomas Kocher

Optimal SARS-CoV-2 vaccine allocation using real-time attack-rate estimates in Rhode Island and Massachusetts

When three SARS-CoV-2 vaccines came to market in Europe and North America in the winter of 2020–2021, distribution networks were in a race against a major epidemiological wave of SARS-CoV-2 that began in autum...

Authors: Thu Nguyen-Anh Tran, Nathan B. Wikle, Emmy Albert, Haider Inam, Emily Strong, Karel Brinda, Scott M. Leighow, Fuhan Yang, Sajid Hossain, Justin R. Pritchard, Philip Chan, William P. Hanage, Ephraim M. Hanks and Maciej F. Boni

The effects of increased dose of hepatitis B vaccine on mother-to-child transmission and immune response for infants born to mothers with chronic hepatitis B infection: a prospective, multicenter, large-sample cohort study

Appropriate passive-active immunoprophylaxis effectively reduces mother-to-child transmission (MTCT) of hepatitis B virus (HBV), but the immunoprophylaxis failure was still more than 5% under the current strat...

Authors: Xiaohui Zhang, Huaibin Zou, Yu Chen, Hua Zhang, Ruihua Tian, Jun Meng, Yunxia Zhu, Huimin Guo, Erhei Dai, Baoshen Zhu, Zhongsheng Liu, Yanxia Jin, Yujie Li, Liping Feng, Hui Zhuang, Calvin Q. Pan…

The East African Community (EAC) mobile laboratory networks in Kenya, Burundi, Tanzania, Rwanda, Uganda, and South Sudan—from project implementation to outbreak response against Dengue, Ebola, COVID-19, and epidemic-prone diseases

East Africa is home to 170 million people and prone to frequent outbreaks of viral haemorrhagic fevers and various bacterial diseases. A major challenge is that epidemics mostly happen in remote areas, where i...

Authors: Muna Affara, Hakim Idris Lagu, Emmanuel Achol, Richard Karamagi, Neema Omari, Grace Ochido, Eric Kezakarayagwa, Francine Kabatesi, Anatole Nkeshimana, Abdi Roba, Millicent Nyakio Ndia, Mamo U. Abudo, Alice Kabanda, Etienne Mpabuka, Emil Ivan Mwikarago, Philip Ezekiel Kutjok…

Metagenome-wide association study of gut microbiome revealed potential microbial marker set for diagnosis of pediatric myasthenia gravis

Myasthenia gravis (MG) is an acquired immune-mediated disorder of the neuromuscular junction that causes fluctuating skeletal muscle weakness and fatigue. Pediatric MG and adult MG have many different characte...

Authors: Peng Liu, Yiqi Jiang, Shanshan Gu, Yinping Xue, Hongxia Yang, Yongzhao Li, Yaxuan Wang, Congya Yan, Pei Jia, Xiaoting Lin and Guoyan Qi

Association of healthy lifestyle score with all-cause mortality and life expectancy: a city-wide prospective cohort study of cancer survivors

Adherence to a healthy lifestyle could reduce the cancer mortality in the western population. We conducted a city-wide prospective study in China investigating the association of a healthy lifestyle score with...

Authors: Ce Sun, Ke Li, Huan Xu, Xiangjun Wang, Pengzhe Qin, Suixiang Wang, Boheng Liang and Lin Xu

Validity of observational evidence on putative risk and protective factors: appraisal of 3744 meta-analyses on 57 topics

The validity of observational studies and their meta-analyses is contested. Here, we aimed to appraise thousands of meta-analyses of observational studies using a pre-specified set of quantitative criteria tha...

Authors: Perrine Janiaud, Arnav Agarwal, Ioanna Tzoulaki, Evropi Theodoratou, Konstantinos K. Tsilidis, Evangelos Evangelou and John P. A. Ioannidis

Longitudinal change in lung function and subsequent risks of cardiovascular events: evidence from four prospective cohort studies

Lung function is constantly changing over the life course. Although the relation of cross-sectional lung function measure and adverse outcomes has been reported, data on longitudinal change and subsequent card...

Authors: Yun-Jiu Cheng, Zhen-Guang Chen, Zhu-Yu Li, Wei-Yi Mei, Wen-Tao Bi and Dong-Ling Luo

Parental income gradients in adult health: a national cohort study

Disparities in health by adult income are well documented, but we know less about the childhood origins of health inequalities, and it remains unclear how the shape of the gradient varies across health conditi...

Authors: Miriam Evensen, Søren Toksvig Klitkou, Mette C. Tollånes, Simon Øverland, Torkild Hovde Lyngstad, Stein Emil Vollset and Jonas Minet Kinge

A phenome-wide association study of genetically mimicked statins

Beyond their success in cardiovascular disease prevention, statins are increasingly recognized to have sex-specific pleiotropic effects. To gain additional insight, we characterized associations of genetically...

Authors: Shun Li and C. M. Schooling

Paediatric rotavirus vaccination, coeliac disease and type 1 diabetes in children: a population-based cohort study

Rotavirus infection has been proposed as a risk factor for coeliac disease (CD) and type 1 diabetes (T1D). The UK introduced infant rotavirus vaccination in 2013. We have previously shown that rotavirus vaccin...

Authors: Thomas Inns, Kate M. Fleming, Miren Iturriza-Gomara and Daniel Hungerford

Persistence and baseline determinants of seropositivity and reinfection rates in health care workers up to 12.5 months after COVID-19

We assessed the duration and baseline determinants of antibody responses to SARS-CoV-2 spike antigens and the occurrence of reinfections in a prospective cohort of 173 Spanish primary health care worker patien...

Authors: Carlota Dobaño, Anna Ramírez-Morros, Selena Alonso, Josep Vidal-Alaball, Gemma Ruiz-Olalla, Marta Vidal, Rocío Rubio, Emma Cascant, Daniel Parras, Natalia Rodrigo Melero, Pau Serra, Carlo Carolis, Pere Santamaria, Anna Forcada, Jacobo Mendioroz, Ruth Aguilar…

Understanding the role of the paramedic in primary care: a realist review

Since 2002, paramedics have been working in primary care within the United Kingdom (UK), a transition also mirrored within Australia, Canada and the USA. Recent recommendations to improve UK NHS workforce capa...

Authors: Georgette Eaton, Geoff Wong, Stephanie Tierney, Nia Roberts, Veronika Williams and Kamal R. Mahtani

Health inequities and clustering of fever, acute respiratory infection, diarrhoea and wasting in children under five in low- and middle-income countries: a Demographic and Health Surveys analysis

Pneumonia, diarrhoea and malaria are responsible for over one third of all deaths in children under the age of 5 years in low and middle sociodemographic index countries; many of these deaths are also associat...

Authors: Peter Winskill, Alexandra B. Hogan, Julie Thwing, Lazaro Mwandigha, Patrick G. T. Walker and Ben Lambert

Relation of severe COVID-19 in Scotland to transmission-related factors and risk conditions eligible for shielding support: REACT-SCOT case-control study

Clinically vulnerable individuals have been advised to shield themselves during the COVID-19 epidemic. The objectives of this study were to investigate (1) the rate ratio of severe COVID-19 associated with eli...

Authors: Paul M. McKeigue, David A. McAllister, David Caldwell, Ciara Gribben, Jen Bishop, Stuart McGurnaghan, Matthew Armstrong, Joke Delvaux, Sam Colville, Sharon Hutchinson, Chris Robertson, Nazir Lone, Jim McMenamin, David Goldberg and Helen M. Colhoun

Adherence to international dietary recommendations in association with all-cause mortality and fatal and non-fatal cardiovascular disease risk: a prospective analysis of UK Biobank participants

International dietary guidelines aim to reduce risks of all-cause mortality, cardiovascular disease (CVD), and fatal CVD often associated with poor dietary habits. However, most studies have examined associati...

Authors: Maryam Kebbe, Min Gao, Aurora Perez-Cornago, Susan A. Jebb and Carmen Piernas

Association of statin use in older people primary prevention group with risk of cardiovascular events and mortality: a systematic review and meta-analysis of observational studies

Current evidence from randomized controlled trials on statins for primary prevention of cardiovascular disease (CVD) in older people, especially those aged > 75 years, is still lacking. We conducted a systemat...

Authors: Kamal Awad, Maged Mohammed, Mahmoud Mohamed Zaki, Abdelrahman I. Abushouk, Gregory Y. H. Lip, Michael J. Blaha, Carl J. Lavie, Peter P. Toth, J. Wouter Jukema, Naveed Sattar and Maciej Banach

Using syndromic measures of mortality to capture the dynamics of COVID-19 in Java, Indonesia, in the context of vaccination rollout

As in many countries, quantifying COVID-19 spread in Indonesia remains challenging due to testing limitations. In Java, non-pharmaceutical interventions (NPIs) were implemented throughout 2020. However, as a v...

Authors: Bimandra A. Djaafara, Charles Whittaker, Oliver J. Watson, Robert Verity, Nicholas F. Brazeau, Widyastuti, Dwi Oktavia, Verry Adrian, Ngabila Salama, Sangeeta Bhatia, Pierre Nouvellet, Ellie Sherrard-Smith, Thomas S. Churcher, Henry Surendra, Rosa N. Lina, Lenny L. Ekawati…

A core outcome set for studies evaluating interventions to prevent and/or treat delirium for adults requiring an acute care hospital admission: an international key stakeholder informed consensus study

Trials of interventions to prevent or treat delirium in adults in an acute hospital setting report heterogeneous outcomes. Our objective was to develop international consensus among key stakeholders for a core...

Authors: Louise Rose, Lisa Burry, Meera Agar, Bronagh Blackwood, Noll L. Campbell, Mike Clarke, John W. Devlin, Jacques Lee, John C. Marshall, Dale M. Needham, Najma Siddiqi and Valerie Page

Impact of replacing sedentary behaviour with other movement behaviours on depression and anxiety symptoms: a prospective cohort study in the UK Biobank

Sedentary behaviour is potentially a modifiable risk factor for depression and anxiety disorders, but findings have been inconsistent. To assess the associations of sedentary behaviour with depression and anxi...

Authors: A. A. Kandola, B. del Pozo Cruz, D. P. J. Osborn, B. Stubbs, K. W. Choi and J. F. Hayes

The risk of ischemic stroke and hemorrhagic stroke in Chinese adults with low-density lipoprotein cholesterol concentrations < 70 mg/dL

The risk of stroke in individuals with very low low-density lipoprotein cholesterol (LDL-C) concentrations remains high. We sought to prioritize predictive risk factors for stroke in Chinese participants with ...

Authors: Zhijun Wu, Zhe Huang, Alice H. Lichtenstein, Yesong Liu, Shuohua Chen, Yao Jin, Muzi Na, Le Bao, Shouling Wu and Xiang Gao

Utilization of the evidence from studies with no events in meta-analyses of adverse events: an empirical investigation

Zero-events studies frequently occur in systematic reviews of adverse events, which consist of an important source of evidence. We aimed to examine how evidence of zero-events studies was utilized in the meta-...

Authors: Chang Xu, Xiaoqin Zhou, Liliane Zorzela, Ke Ju, Luis Furuya-Kanamori, Lifeng Lin, Cuncun Lu, Omran A. H. Musa and Sunita Vohra

Perspectives of tumor-infiltrating lymphocyte treatment in solid tumors

Tumor-infiltrating lymphocyte (TIL) therapy is a type of adoptive cellular therapy by harvesting infiltrated lymphocytes from tumors, culturing and amplifying them in vitro and then infusing back to treat pati...

Authors: Shuhang Wang, Jingwei Sun, Kun Chen, Peiwen Ma, Qi Lei, Shujun Xing, Zhongzheng Cao, Shujun Sun, Zicheng Yu, Yarong Liu and Ning Li

A randomized controlled trial of dihydroartemisinin-piperaquine, artesunate-mefloquine and extended artemether-lumefantrine treatments for malaria in pregnancy on the Thailand-Myanmar border

Artemisinin and artemisinin-based combination therapy (ACT) partner drug resistance in Plasmodium falciparum have spread across the Greater Mekong Subregion compromising antimalarial treatment. The current 3-day ...

Authors: Makoto Saito, Verena I. Carrara, Mary Ellen Gilder, Aung Myat Min, Nay Win Tun, Mupawjay Pimanpanarak, Jacher Viladpai-nguen, Moo Kho Paw, Warat Haohankhunnatham, Kamonchanok Konghahong, Aung Pyae Phyo, Cindy Chu, Claudia Turner, Sue J. Lee, Jureeporn Duanguppama, Mallika Imwong…

Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke

Acute ischemic stroke (AIS) is a serious cause of mortality and disability. AIS is a serious cause of mortality and disability. Early diagnosis of atherosclerosis, which is the major cause of AIS, allows thera...

Authors: Takaki Hiwasa, Hao Wang, Ken-ichiro Goto, Seiichiro Mine, Toshio Machida, Eiichi Kobayashi, Yoichi Yoshida, Akihiko Adachi, Tomoo Matsutani, Mizuki Sata, Kazumasa Yamagishi, Hiroyasu Iso, Norie Sawada, Shoichiro Tsugane, Mitoshi Kunimatsu, Ikuo Kamitsukasa…

A phase IV, multi-centre, randomized clinical trial comparing two pertussis-containing vaccines in pregnant women in England and vaccine responses in their infants

Pertussis vaccines containing three or five pertussis antigens are recommended in pregnancy in many countries, but no studies have compared the effect on infants’ antigen-specific immunoglobulin G (IgG) concen...

Authors: Christine Elizabeth Jones, Anna Calvert, Jo Southern, Mary Matheson, Nick Andrews, Asma Khalil, Hannah Cuthbertson, Bassam Hallis, Anna England, Paul T. Heath and Elizabeth Miller

An analysis of school absences in England during the COVID-19 pandemic

The introduction of SARS-CoV-2, the virus that causes COVID-19 infection, in the UK in early 2020, resulted in the introduction of several control policies to reduce disease spread. As part of these restrictio...

Authors: Emma Southall, Alex Holmes, Edward M. Hill, Benjamin D. Atkins, Trystan Leng, Robin N. Thompson, Louise Dyson, Matt J. Keeling and Michael J. Tildesley

Renin-angiotensin system blockers and COVID-19

Authors: Emmanuelle Vidal-Petiot and Nathalie Gault

Clinical features of bacterial meningitis among hospitalised children in Kenya

Diagnosing bacterial meningitis is essential to optimise the type and duration of antimicrobial therapy to limit mortality and sequelae. In sub-Saharan Africa, many public hospitals lack laboratory capacity, r...

Authors: Christina W. Obiero, Neema Mturi, Salim Mwarumba, Moses Ngari, Charles R. Newton, Michaël Boele van Hensbroek and James A. Berkley

Understanding menstrual cycle effects on suicide will require prospective studies of suicidal thoughts and behaviors in premenstrual disorders

Authors: Sarah A. Owens and Tory A. Eisenlohr-Moul

Promoting physical activity in a multi-ethnic population at high risk of diabetes: the 48-month PROPELS randomised controlled trial

Physical activity is associated with a reduced risk of type 2 diabetes and cardiovascular disease but limited evidence exists for the sustained promotion of increased physical activity within diabetes preventi...

Authors: Kamlesh Khunti, Simon Griffin, Alan Brennan, Helen Dallosso, Melanie J. Davies, Helen C. Eborall, Charlotte L. Edwardson, Laura J. Gray, Wendy Hardeman, Laura Heathcote, Joe Henson, Daniel Pollard, Stephen J. Sharp, Stephen Sutton, Jacqui Troughton and Tom Yates

The effects of dietary and lifestyle interventions among pregnant women with overweight or obesity on early childhood outcomes: an individual participant data meta-analysis from randomised trials

The impact of maternal obesity extends beyond birth, being independently associated with an increased risk of child obesity. Current evidence demonstrates that women provided with a dietary intervention during...

Authors: Jennie Louise, Amanda J. Poprzeczny, Andrea R. Deussen, Christina Vinter, Mette Tanvig, Dorte Moller Jensen, Annick Bogaerts, Roland Devlieger, Fionnuala M. McAuliffe, Kristina M. Renault, Emma Carlsen, Nina Geiker, Lucilla Poston, Annette Briley, Shakila Thangaratinam and Jodie M. Dodd

Long-term impact of a conditional cash transfer programme on maternal mortality: a nationwide analysis of Brazilian longitudinal data

Reducing poverty and improving access to health care are two of the most effective actions to decrease maternal mortality, and conditional cash transfer (CCT) programmes act on both. The aim of this study was ...

Authors: Davide Rasella, Flávia Jôse Oliveira Alves, Poliana Rebouças, Gabriela Santos de Jesus, Maurício L. Barreto, Tereza Campello and Enny S. Paixao

Community-based molecular and serological surveillance of subclinical malaria in Myanmar

In the Greater Mekong Subregion (GMS), current malaria surveillance strategies rely on a network of village health volunteers (VHVs) reporting the results of rapid diagnostic tests (RDTs), known to miss many a...

Authors: Katherine O’Flaherty, Win Han Oo, Sophie G. Zaloumis, Julia C. Cutts, Kyaw Zayar Aung, Myat Mon Thein, Damien R. Drew, Zahra Razook, Alyssa E. Barry, Naanki Parischa, Nyi Nyi Zaw, Htin Kyaw Thu, Aung Thi, Wai Yan Min Htay, Aung Paing Soe, Julie A. Simpson…

Gestational diabetes mellitus is associated with the neonatal gut microbiota and metabolome

Gestational diabetes mellitus (GDM) is a metabolic disease that occurs in pregnant women and increases the risk for the development of diabetes. The relationship between GDM and meconium microbiota and metabol...

Authors: Ting Chen, Yufeng Qin, Minjian Chen, Yuqing Zhang, Xu Wang, Tianyu Dong, Guanglin Chen, Xian Sun, Ting Lu, Richard Allen White III, Peng Ye, Hein M. Tun and Yankai Xia

Clinical indications of premenstrual disorders and subsequent risk of injury: a population-based cohort study in Sweden

Premenstrual disorders, including premenstrual syndrome and premenstrual dysphoric disorder, are suggested to be correlated with suicidal behavior and accidents in cross-sectional and retrospective studies. Ho...

Authors: Qian Yang, Arvid Sjölander, Yuchen Li, Alexander Viktorin, Elizabeth R. Bertone-Johnson, Weimin Ye, Fang Fang, Unnur A. Valdimarsdóttir and Donghao Lu

Risk of major labour-related complications for pregnancies progressing to 42 weeks or beyond

Post-term gestation beyond 41⁺⁶ completed weeks of gestation is known to be associated with a sharp increase in the risk of stillbirth and perinatal mortality. However, the risk of common adverse outcomes related...

Authors: Anthea C. Lindquist, Roxanne M. Hastie, Richard J. Hiscock, Natasha L. Pritchard, Susan P. Walker and Stephen Tong