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  1. Content type: Research article

    The World Health Organization has set an ambitious goal of eliminating viral hepatitis as a major public health threat by 2030. However, in sub-Saharan Africa, antiviral treatment of chronic hepatitis B (CHB) ...

    Authors: Hailemichael Desalegn, Hanna Aberra, Nega Berhe, Bitsatab Mekasha, Kathrine Stene-Johansen, Henrik Krarup, Andre Puntervold Pereira, Svein Gunnar Gundersen and Asgeir Johannessen

    Citation: BMC Medicine 2018 16:234

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  2. Content type: Editorial

    There is clear guidance on the responsibilities of editors to ensure that the research they publish is of the highest possible quality. Poor reporting is unethical and directly impacts patient care. Reporting ...

    Authors: David Moher

    Citation: BMC Medicine 2018 16:233

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  3. Content type: Correction

    The original article [1] contained an error whereby Table 5 within the Appendix is presented incorrectly. This error has now been corrected and Table 5 is presented appropriately.

    Authors: Kulapong Jayanama, Olga Theou, Joanna M. Blodgett, Leah Cahill and Kenneth Rockwood

    Citation: BMC Medicine 2018 16:235

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    The original article was published in BMC Medicine 2018 16:188

  4. Content type: Review

    Lifestyle factors conferring increased diabetes risk are associated with elevated basal insulin levels (hyperinsulinaemia). The latter predicts later obesity in children and adolescents.

    Authors: Hubert Kolb, Michael Stumvoll, Werner Kramer, Kerstin Kempf and Stephan Martin

    Citation: BMC Medicine 2018 16:232

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  5. Content type: Research article

    As part of a national programme to tackle ethnic inequalities, we conducted a systematic review and meta-analysis of research on ethnic inequalities in pathways to care for adults with psychosis living in Engl...

    Authors: Kristoffer Halvorsrud, James Nazroo, Michaela Otis, Eva Brown Hajdukova and Kamaldeep Bhui

    Citation: BMC Medicine 2018 16:223

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  6. Content type: Research article

    Cognitive spectrum disorders (CSDs) are common in hospitalised older adults and associated with adverse outcomes. Their association with the maintenance of independent living has not been established. The aim ...

    Authors: Jennifer K. Burton, Bruce Guthrie, Simona M. Hapca, Vera Cvoro, Peter T. Donnan and Emma L. Reynish

    Citation: BMC Medicine 2018 16:231

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  7. Content type: Research article

    Mass drug administration (MDA) has the potential to interrupt malaria transmission and has been suggested as a tool for malaria elimination in low-endemic settings. This study aimed to determine the effectiven...

    Authors: Ulrika Morris, Mwinyi I. Msellem, Humphrey Mkali, Atiqul Islam, Berit Aydin-Schmidt, Irina Jovel, Shija Joseph Shija, Mwinyi Khamis, Safia Mohammed Ali, Lamija Hodzic, Ellinor Magnusson, Eugenie Poirot, Adam Bennett, Michael C. Sachs, Joel Tarning, Andreas Mårtensson…

    Citation: BMC Medicine 2018 16:215

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  8. Content type: Research article

    The predictive validity of postgraduate examinations, such as MRCGP and MRCP(UK) in the UK, is hard to assess, particularly for clinically relevant outcomes. The sanctions imposed on doctors by the UK’s Genera...

    Authors: Richard Wakeford, Kasia Ludka, Katherine Woolf and I. C. McManus

    Citation: BMC Medicine 2018 16:230

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  9. Content type: Research article

    The newly registered adjuvanted herpes zoster subunit vaccine (HZ/su) has a higher efficacy than the available live-attenuated vaccine (ZVL). National decision-makers soon need to decide whether to introduce H...

    Authors: Pieter T. de Boer, Alies van Lier, Hester de Melker, Albert J. M. van Wijck, Jan C. Wilschut, Albert Jan van Hoek and Maarten J. Postma

    Citation: BMC Medicine 2018 16:228

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  10. Content type: Research article

    Emerging evidence suggests intensity of perinatal care influences survival for extremely preterm babies. We evaluated the effect of differences in perinatal care intensity between centres on sensorimotor morbi...

    Authors: Andrei S. Morgan, Laurence Foix L’Helias, Caroline Diguisto, Laetitia Marchand-Martin, Monique Kaminski, Babak Khoshnood, Jennifer Zeitlin, Gérard Bréart, Xavier Durrmeyer, François Goffinet and Pierre-Yves Ancel

    Citation: BMC Medicine 2018 16:227

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  11. Content type: Commentary

    Malaria transmission is highly heterogeneous through time and space, and mapping of this heterogeneity is necessary to better understand local dynamics. New targeted policies are needed as numerous countries h...

    Authors: Jordi Landier, Stanislas Rebaudet, Renaud Piarroux and Jean Gaudart

    Citation: BMC Medicine 2018 16:226

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    The original article was published in Malaria Journal 2018 17:340

  12. Content type: Research article

    Previous evidence indicates that sauna bathing is related to a reduced risk of fatal cardiovascular disease (CVD) events in men. The aim of this study was to investigate the relationship between sauna habits a...

    Authors: Tanjaniina Laukkanen, Setor K. Kunutsor, Hassan Khan, Peter Willeit, Francesco Zaccardi and Jari A. Laukkanen

    Citation: BMC Medicine 2018 16:219

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  13. Content type: Research article

    Birth weight and early child growth are important predictors of long-term cardiometabolic disease risk, in line with the Developmental Origins of Health and Disease hypothesis. As human assisted reproductive t...

    Authors: Mark Hann, Stephen A. Roberts, Stephen W. D’Souza, Peter Clayton, Nick Macklon and Daniel R. Brison

    Citation: BMC Medicine 2018 16:224

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  14. Content type: Research article

    Plasmodium ovale spp. and P. malariae cause illness in endemic regions and returning travellers. Far less is known about these species than P. falciparum and P. vivax.

    Authors: Laura E. B. Nabarro, Debbie Nolder, Claire Broderick, Behzad Nadjm, Valerie Smith, Marie Blaze, Anna M. Checkley, Peter L. Chiodini, Colin J. Sutherland and Christopher J. M. Whitty

    Citation: BMC Medicine 2018 16:218

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  15. Content type: Commentary

    Understanding the long-term health impacts of the early-life exposome requires the characterization and assimilation of multi ‘omics’ data to ultimately link molecular changes to exposures. In this way, marker...

    Authors: Alicia DiBattista and Pranesh Chakraborty

    Citation: BMC Medicine 2018 16:222

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    The original article was published in BMC Medicine 2018 16:202

  16. Content type: Editorial

    The past 15 years have seen the emergence of a new paradigm in medical research, namely of people living with medical conditions (whether patients, parents, or caregivers) using digital tools to conduct N-of-1...

    Authors: Paul Wicks

    Citation: BMC Medicine 2018 16:217

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  17. Content type: Editorial

    Pancreatic cancer is the fourth leading cause of cancer-related death in the United States, with increasing incidence. The mortality rate of pancreatic cancer is rising rapidly, and is projected to be the seco...

    Authors: Huiyun Zhu, Tuo Li, Yiqi Du and Min Li

    Citation: BMC Medicine 2018 16:214

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  18. Content type: Commentary

    Improving clinical outcomes and quality of care in diseases such as sepsis, which are heterogeneous in their presenting signs and symptoms, is a challenge. One approach is to utilise the Functional Analysis Re...

    Authors: Damian Roland

    Citation: BMC Medicine 2018 16:213

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    The original article was published in BMC Medicine 2018 16:174

  19. Content type: Guideline

    Adequate reporting of adaptive designs (ADs) maximises their potential benefits in the conduct of clinical trials. Transparent reporting can help address some obstacles and concerns relating to the use of ADs....

    Authors: Munyaradzi Dimairo, Elizabeth Coates, Philip Pallmann, Susan Todd, Steven A. Julious, Thomas Jaki, James Wason, Adrian P. Mander, Christopher J. Weir, Franz Koenig, Marc K. Walton, Katie Biggs, Jon Nicholl, Toshimitsu Hamasaki, Michael A. Proschan, John A. Scott…

    Citation: BMC Medicine 2018 16:210

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  20. Content type: Research article

    It is presumed that pharmacological and non-pharmacological treatment of prenatal common mental disorders can mitigate associated adverse effects in offspring, yet strong evidence for the prophylactic benefits...

    Authors: Marlies E. Brouwer, Alishia D. Williams, Sam E. van Grinsven, Pim Cuijpers, Mijke P. Lambregtse-van den Berg, Huibert Burger and Claudi L. H. Bockting

    Citation: BMC Medicine 2018 16:208

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  21. Content type: Research article

    Concerns have been raised that observing other people using e-cigarettes may undermine motivation to quit by renormalising smoking. This study aimed to explore associations between regular exposure to other pe...

    Authors: Sarah E. Jackson, Emma Beard, Susan Michie, Lion Shahab, Tobias Raupach, Robert West and Jamie Brown

    Citation: BMC Medicine 2018 16:206

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  22. Content type: Commentary

    Spatial epidemiology is a rapidly advancing field, pushing our abilities to measure, monitor and map pathogens at increasingly finer spatiotemporal scales. However, these scales often do not align with the abi...

    Authors: Andrew J. Tatem

    Citation: BMC Medicine 2018 16:209

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  23. Content type: Research article

    In 2005, the FDA cautioned that exposure to paroxetine, a selective serotonin reuptake inhibitor (SSRI), during the first trimester of pregnancy may increase the risk of cardiac malformations. Since then, the ...

    Authors: Shan-Yan Gao, Qi-Jun Wu, Ce Sun, Tie-Ning Zhang, Zi-Qi Shen, Cai-Xia Liu, Ting-Ting Gong, Xin Xu, Chao Ji, Dong-Hui Huang, Qing Chang and Yu-Hong Zhao

    Citation: BMC Medicine 2018 16:205

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  24. Content type: Research article

    Environment and diet in early life can affect development and health throughout the life course. Metabolic phenotyping of urine and serum represents a complementary systems-wide approach to elucidate environme...

    Authors: Chung-Ho E. Lau, Alexandros P. Siskos, Léa Maitre, Oliver Robinson, Toby J. Athersuch, Elizabeth J. Want, Jose Urquiza, Maribel Casas, Marina Vafeiadi, Theano Roumeliotaki, Rosemary R. C. McEachan, Rafaq Azad, Line S. Haug, Helle M. Meltzer, Sandra Andrusaityte, Inga Petraviciene…

    Citation: BMC Medicine 2018 16:202

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    The Commentary to this article has been published in BMC Medicine 2018 16:222

  25. Content type: Research article

    Several quinoline and structurally related antimalarial drugs are associated with cardiovascular side effects, particularly hypotension and electrocardiographic QT interval prolongation. A prolonged QT interva...

    Authors: Ilsa L. Haeusler, Xin Hui S. Chan, Philippe J. Guérin and Nicholas J. White

    Citation: BMC Medicine 2018 16:200

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  26. Content type: Research article

    Maternal gestational diabetes (GDM) is an established risk factor for large size at birth, but its influence on intrauterine fetal growth in different ethnic populations is less well understood. Here, we exami...

    Authors: Judith S. Brand, Jane West, Derek Tuffnell, Philippa K. Bird, John Wright, Kate Tilling and Debbie A. Lawlor

    Citation: BMC Medicine 2018 16:203

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  27. Content type: Research article

    Gestational weight gain differs according to pre-pregnancy body mass index and is related to the risks of adverse maternal and child health outcomes. Gestational weight gain charts for women in different pre-p...

    Authors: Susana Santos, Iris Eekhout, Ellis Voerman, Romy Gaillard, Henrique Barros, Marie-Aline Charles, Leda Chatzi, Cécile Chevrier, George P. Chrousos, Eva Corpeleijn, Nathalie Costet, Sarah Crozier, Myriam Doyon, Merete Eggesbø, Maria Pia Fantini, Sara Farchi…

    Citation: BMC Medicine 2018 16:201

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  28. Content type: Research article

    Factors driving inter-individual differences in immune responses upon different types of prenatal malaria exposure (PME) and subsequent risk of malaria in infancy remain poorly understood. In this study, we ex...

    Authors: Hamtandi Magloire Natama, Gemma Moncunill, Eduard Rovira-Vallbona, Héctor Sanz, Hermann Sorgho, Ruth Aguilar, Maminata Coulibaly-Traoré, M. Athanase Somé, Susana Scott, Innocent Valéa, Petra F. Mens, Henk D. F. H. Schallig, Luc Kestens, Halidou Tinto, Carlota Dobaño and Anna Rosanas-Urgell

    Citation: BMC Medicine 2018 16:198

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    The Commentary to this article has been published in BMC Medicine 2018 16:212

  29. Content type: Research article

    Childhood malnutrition remains highly prevalent in low-income countries, and a 40% reduction in under-5 year stunting is WHO’s top Global Target 2025. Disappointingly, meta-analyses of intensive nutrition inte...

    Authors: Mayya Husseini, Momodou K Darboe, Sophie E Moore, Helen M Nabwera and Andrew M Prentice

    Citation: BMC Medicine 2018 16:199

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  30. Content type: Research article

    The RTS,S/AS01E vaccine provides partial protection against malaria in African children, but immune responses have only been partially characterized and do not reliably predict protective efficacy. We aimed to...

    Authors: Itziar Ubillos, Aintzane Ayestaran, Augusto J Nhabomba, David Dosoo, Marta Vidal, Alfons Jiménez, Chenjerai Jairoce, Hèctor Sanz, Ruth Aguilar, Nana Aba Williams, Núria Díez-Padrisa, Maximilian Mpina, Hermann Sorgho, Selidji Todagbe Agnandji, Simon Kariuki, Benjamin Mordmüller…

    Citation: BMC Medicine 2018 16:197

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  31. Content type: Research article

    The host, microbial, and environmental factors that contribute to variation in tuberculosis (TB) disease are incompletely understood. Accumulating evidence suggests that one driver of geographic variation in T...

    Authors: Kirsten E Wiens, Lauren P Woyczynski, Jorge R Ledesma, Jennifer M Ross, Roberto Zenteno-Cuevas, Amador Goodridge, Irfan Ullah, Barun Mathema, Joel Fleury Djoba Siawaya, Molly H Biehl, Sarah E Ray, Natalia V Bhattacharjee, Nathaniel J Henry, Robert C Reiner Jr, Hmwe H Kyu, Christopher J L Murray…

    Citation: BMC Medicine 2018 16:196

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  32. Content type: Research article

    Despite substantial improvement in the control of malaria and decreased prevalence of malnutrition over the past two decades, both conditions remain heavy burdens that cause hundreds of thousands of deaths in ...

    Authors: D Das, R F Grais, E A Okiro, K Stepniewska, R Mansoor, S van der Kam, D J Terlouw, J Tarning, K I Barnes and P J Guerin

    Citation: BMC Medicine 2018 16:186

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  33. Content type: Research article

    Nutritional status and individual nutrients have been associated with frailty in older adults. The extent to which these associations hold in younger people, by type of malnutrition or grades of frailty, is un...

    Authors: Kulapong Jayanama, Olga Theou, Joanna M Blodgett, Leah Cahill and Kenneth Rockwood

    Citation: BMC Medicine 2018 16:188

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    The Correction to this article has been published in BMC Medicine 2018 16:235

  34. Content type: Research article

    Adult height is associated with risk of several diseases, but the breadth of such associations and whether these associations are primary or due to confounding are unclear. We examined the association of adult...

    Authors: Florence Y. Lai, Mintu Nath, Stephen E. Hamby, John R. Thompson, Christopher P. Nelson and Nilesh J. Samani

    Citation: BMC Medicine 2018 16:187

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  35. Content type: Research article

    Whether physical activity can reduce cognitive frailty—a relatively new “compound” phenotype proposed in 2013—and whether the effect of physical activity differs based on levels of inflammation are unknown. Th...

    Authors: Zuyun Liu, Fang-Chi Hsu, Andrea Trombetti, Abby C. King, Christine K. Liu, Todd M. Manini, Roger A. Fielding, Marco Pahor, Anne B. Newman, Stephen Kritchevsky and Thomas M. Gill

    Citation: BMC Medicine 2018 16:185

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  36. Content type: Research article

    Maternal lifestyle factors, including smoking and increased body weight, increase risks of adult diseases such as metabolic syndrome and infertility. The fetal thyroid gland is essential for the control of fet...

    Authors: Panagiotis Filis, Sabine Hombach-Klonisch, Pierre Ayotte, Nalin Nagrath, Ugo Soffientini, Thomas Klonisch, Peter O’Shaughnessy and Paul A. Fowler

    Citation: BMC Medicine 2018 16:194

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  37. Content type: Research article

    Community health workers (CHWs) can provide diagnosis and treatment of malaria in remote rural areas and are therefore key to the elimination of malaria. However, as incidence declines, uptake of their service...

    Authors: Alistair R. D. McLean, Hla Phyo Wai, Aung Myat Thu, Zay Soe Khant, Chanida Indrasuta, Elizabeth A. Ashley, Thar Tun Kyaw, Nicholas P. J. Day, Arjen Dondorp, Nicholas J. White and Frank M. Smithuis

    Citation: BMC Medicine 2018 16:183

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  38. Content type: Research article

    Long waiting times are associated with public community outpatient health services. This trial aimed to determine if a new model of care based on evidence-based strategies that improved patient flow in two sma...

    Authors: Katherine E. Harding, Sandra G. Leggat, Jennifer J. Watts, Bridie Kent, Luke Prendergast, Michelle Kotis, Mary O’Reilly, Leila Karimi, Annie K. Lewis, David A. Snowdon and Nicholas F. Taylor

    Citation: BMC Medicine 2018 16:182

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  39. Content type: Opinion

    Recent global progress in scaling up malaria control interventions has revived the goal of complete elimination in many countries. Decreasing transmission intensity generally leads to increasingly patchy spati...

    Authors: Amy Wesolowski, Aimee R Taylor, Hsiao-Han Chang, Robert Verity, Sofonias Tessema, Jeffrey A Bailey, T Alex Perkins, Daniel E Neafsey, Bryan Greenhouse and Caroline O Buckee

    Citation: BMC Medicine 2018 16:190

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  40. Content type: Research article

    Local mosquito-borne Zika virus (ZIKV) transmission has been reported in two counties in the contiguous United States (US), prompting the issuance of travel, prevention, and testing guidance across the contigu...

    Authors: Kaiyuan Sun, Qian Zhang, Ana Pastore-Piontti, Matteo Chinazzi, Dina Mistry, Natalie E Dean, Diana Patricia Rojas, Stefano Merler, Piero Poletti, Luca Rossi, M Elizabeth Halloran, Ira M Longini Jr and Alessandro Vespignani

    Citation: BMC Medicine 2018 16:195

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  41. Content type: Research article

    Tuberculosis (TB) transmission often occurs within a household or community, leading to heterogeneous spatial patterns. However, apparent spatial clustering of TB could reflect ongoing transmission or co-locat...

    Authors: Debebe Shaweno, Malancha Karmakar, Kefyalew Addis Alene, Romain Ragonnet, Archie CA Clements, James M. Trauer, Justin T. Denholm and Emma S. McBryde

    Citation: BMC Medicine 2018 16:193

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