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  1. Migraine headache is a major public health problem. Routine medications for migraine treatment are not useful in treating all patients and may have some side effects. The present study aimed to investigate the...

    Authors: Shahnaz Amani Tirani, Fariborz Khorvash, Parvane Saneei, Zahra Moradmand and Gholamreza Askari
    Citation: BMC Medicine 2024 22:457
    Content type: Research Published on:

  2. The hippocampus, with its complex subfields, is linked to numerous neuropsychiatric traits. While most research has focused on its global structure or a few specific subfields, a comprehensive analysis of hipp...

    Authors: Caibo Ning, Meng Jin, Yimin Cai, Linyun Fan, Kexin Hu, Zequn Lu, Ming Zhang, Can Chen, Yanmin Li, Naifan Hu, Donghui Zhang, Yizhuo Liu, Shuoni Chen, Yuan Jiang, Chunyi He, Zhuo Wang…
    Citation: BMC Medicine 2024 22:456
    Content type: Research Published on:

  3. A growing body of evidence supports the comorbidity between depression (DEP) and obesity, yet the genetic mechanisms underlying this association remain unclear. Our study explored the shared genetic architectu...

    Authors: Hengyu Zhang, Rui Zheng, Binhe Yu, Yuefeng Yu, Xiaomin Luo, Shujuan Yin, Yingjun Zheng, Jie Shi and Sizhi Ai
    Citation: BMC Medicine 2024 22:455
    Content type: Research Published on:

  4. Adverse pregnancy outcomes have reached epidemic proportions in recent years with serious health ramifications, especially for diverse cancers risk. Therefore, we carried out an umbrella review to systematical...

    Authors: Na Liu, Rui-Han Bao, Yu-Jiao Chang, Fang-Hua Liu, Lang Wu, Jia-Yi Wang, Zi-Ping Niu, Shuai Ma, Yi-Xuan Men, Ke-Xin Liu, Dong-Hui Huang, Qian Xiao, Song Gao, Yue-Yang Zhao, Jian-Hua Fu, Qi-Jun Wu…
    Citation: BMC Medicine 2024 22:454
    Content type: Research Published on:

  5. Despite free immunisation services through the Universal Immunisation Programme (UIP), around 14% of Indian households seek immunisation in the private sector. We examined the potential impact of rotavirus vac...

    Authors: Habib Hasan Farooqui, Anup Karan, Aashna Mehta, Giridhara Rathnaiah Babu and Onno C. P. van Schayck
    Citation: BMC Medicine 2024 22:453
    Content type: Research article Published on:

  6. Prognostic models that identify individuals with chronic kidney disease (CKD) at greatest risk of developing kidney failure help clinicians to make decisions and deliver precision medicine. It is recognised th...

    Authors: Heather Walker, Scott Day, Christopher H. Grant, Catrin Jones, Robert Ker, Michael K. Sullivan, Bhautesh Dinesh Jani, Katie Gallacher and Patrick B. Mark
    Citation: BMC Medicine 2024 22:452
    Content type: Research Published on:

  7. The suicide risk in patients with atrial fibrillation receiving novel oral anticoagulants or warfarin has not been evaluated in real-world practice. Moreover, reducing vitamin K levels may increase the suicide...

    Authors: Brian Meng-Hsun Li, Avery Shuei-He Yang, Michael Chun-Yuan Cheng, Huei-Kai Huang and Edward Chia-Cheng Lai
    Citation: BMC Medicine 2024 22:451
    Content type: Research Published on:

  8. Trial registration aims to address potential bias from selective or non-reporting of findings, and therefore has a vital role in promoting transparency and accountability of clinical research. In this study, w...

    Authors: Chang Xu, Shiqi Fan, Luis Furuya-Kanamori, Sheyu Li, Lifeng Lin, Haitao Chu, Su Golder, Yoon Loke and Sunita Vohra
    Citation: BMC Medicine 2024 22:450
    Content type: Research article Published on:

  9. Pre-diagnostic disturbances in the microbiome-derived metabolome have been associated with an increased risk of diabetes in non-pregnant populations. However, the roles of microbiome-derived metabolites, the e...

    Authors: Sita Manasa Susarla, Oliver Fiehn, Ines Thiele, Amanda L. Ngo, Dinesh K. Barupal, Rana F. Chehab, Assiamira Ferrara and Yeyi Zhu
    Citation: BMC Medicine 2024 22:449
    Content type: Research Published on:

  11. Authors: Melissa A. Day, Marcia A. Ciol, M. Elena Mendoza, Jeffrey Borckardt, Dawn M. Ehde, Andrea K. Newman, Joy F. Chan, Sydney A. Drever, Janna L. Friedly, John Burns, Beverly E. Thorn and Mark P. Jensen
    Citation: BMC Medicine 2024 22:447
    Content type: Correction Published on:

    The original article was published in BMC Medicine 2024 22:156

  12. Post-COVID-19 Syndrome (PCS) entails a spectrum of symptoms, including fatigue, reduced physical performance, dyspnea, cognitive impairment, and psychological distress. Given the effectiveness of exercise-base...

    Authors: René Garbsch, Hendrik Schäfer, Mona Kotewitsch, Johanna M. Mooren, Melina Waranski, Marc Teschler, Katalin Vereckei, Gereon Böll, Frank C. Mooren and Boris Schmitz
    Citation: BMC Medicine 2024 22:446
    Content type: Research article Published on:

  13. Long COVID, also known as post-acute sequelae of COVID-19 (PASC), is a poorly understood condition with symptoms across a range of biological domains that often have debilitating consequences. Some have recent...

    Authors: Zachary Butzin-Dozier, Yunwen Ji, Sarang Deshpande, Eric Hurwitz, A. Jerrod Anzalone, Jeremy Coyle, Junming Shi, Andrew Mertens, Mark J. van der Laan, John M. Colford Jr, Rena C. Patel and Alan E. Hubbard
    Citation: BMC Medicine 2024 22:445
    Content type: Research article Published on:

  14. Premature ovarian insufficiency (POI) is a reproductive disorder characterized by the cessation of ovarian function before the age of 40. Although mitochondrial dysfunction and immune disorders are believed to...

    Authors: Minjun Lu, Wenxin Li, Jiamin Zhou, Junyu Shang, Li Lin, Yueqin Liu and Xiaolan Zhu
    Citation: BMC Medicine 2024 22:444
    Content type: Research Published on:

  15. Up to 17% of cancer survivors have been reported to develop second primary cancers (SPC), which cause significant physical and economic distress and often complicate clinical decision-making. However, understa...

    Authors: Zi-Xuan Rong, Wei Wei, Qin Zeng, Xiao-Ting Cai, Yuan-Yuan Wang, Jian Wang, He-San Luo, Lu-Shan Xiao, Jia-Run Lin, Xue Bai, Yan-Pei Zhang, Duan-Duan Han, Zhong-Yi Dong, Wei Wang, De-Hua Wu and Si-Cong Ma
    Citation: BMC Medicine 2024 22:443
    Content type: Research Published on:

  16. Increased levels of physical activity are associated with a reduction of breast cancer mortality, especially in postmenopausal women with positive hormone receptor status. So far, previous observational case–c...

    Authors: Philipp Zimmer, Tobias Esser, Diana Lueftner, Florian Schuetz, Freerk T. Baumann, Achim Rody, Andreas Schneeweiss, Andreas D. Hartkopf, Thomas Decker, Christoph Uleer, Oliver J. Stoetzer, Frank Foerster, Marcus Schmidt, Christoph Mundhenke, Karen Steindorf, Hans Tesch…
    Citation: BMC Medicine 2024 22:442
    Content type: Research article Published on:

  17. Delayed diagnosis of inflammatory bowel disease (IBD) is common, there is still no effective imaging system to distinguish Crohn's Disease (CD) and Ulcerative Colitis (UC) patients.

    Authors: Ziman Xiong, Yan Zhang, Peili Wu, Jun Chen, Yaqi Shen, Ihab Kamel, Xianying Zheng, Bing Wu and Zhen Li
    Citation: BMC Medicine 2024 22:441
    Content type: Research article Published on:

  18. The majority of men referred with a raised PSA for suspected prostate cancer will receive unnecessary tertiary investigations including MRI and biopsy. Here, we compared different types of biomarkers to refine...

    Authors: Artitaya Lophatananon, Kenneth R. Muir and Vincent J. Gnanapragasam
    Citation: BMC Medicine 2024 22:440
    Content type: Research Published on:

  19. Left ventricular hypertrabeculation (LVHT) is a heterogeneous entity with life-threatening complications and variable prognosis. However, there are limited prediction models available to identify individuals a...

    Authors: Limin Liu, Rui Zeng, Ligang Ding, Simin Cai, Aiyue Chen, Yuchen Dong, Likun Zhou, Mengtong Xu, Yuanwei Xu, Le Li, Zhenhao Zhang, Zhao Hu, Zhuxin Zhang, Yulong Xiong, Zhicheng Hu, Yongqing Li…
    Citation: BMC Medicine 2024 22:439
    Content type: Research Published on:

  20. The associations of weight change with all-cause and cause-specific mortality stratified by age remains unclear. We evaluated the age-stratified (< 65 vs ≥ 65 years) associations of weight change with all-caus...

    Authors: Qing-Mei Huang, Dong Shen, Jian Gao, Huan Chen, Jia-Hao Xie, Hao-Yu Yan, Bin Wu, Zhi-Hao Li, Gang Liu and Chen Mao
    Citation: BMC Medicine 2024 22:438
    Content type: Research Published on:

  21. A voluntary National Healthy Food and Drink Policy (the Policy) was introduced in public hospitals in New Zealand in 2016. This study assessed the changes in implementation of the Policy and its impact on prov...

    Authors: Sally Mackay, Magda Rosin, Bruce Kidd, Sarah Gerritsen, Stephanie Shen, Yannan Jiang, Lisa Te Morenga and Cliona Ni Mhurchu
    Citation: BMC Medicine 2024 22:437
    Content type: Research Published on:

  22. A blood-based diagnostic test is a promising strategy for colorectal cancer (CRC). The MethyDT test (IColohunter), which detects methylation levels of NTMT1 and MAP3K14-AS1, exhibited potential in discriminating ...

    Authors: Zhijie Wang, Zixuan He, Rong Lin, Zhijie Feng, Xiuling Li, Xiangyu Sui, Lun Gu, Tian Xia, Dihan Zhou, Bali Zhao, Yanqing Li, Zhaoshen Li and Yu Bai
    Citation: BMC Medicine 2024 22:436
    Content type: Research Published on:

  23. Health-related stigma and its internalization among individuals with chronic health conditions contribute to impaired mental and physical health and quality of life. Research on health-related stigma has been ...

    Authors: Rebecca L. Pearl, Yulin Li, Laurie C. Groshon, Marian Hernandez, Danielle Saunders, Miriam Sheynblyum, Kimberly A. Driscoll, Joel M. Gelfand, Preeti Manavalan, Marjorie Montanez-Wiscovich, Deidre B. Pereira, Rebecca M. Puhl, Thomas A. Wadden, Lori B. Waxenberg, Sarah C. Westen and Xiang-Yang Lou
    Citation: BMC Medicine 2024 22:435
    Content type: Research Published on:

  26. Parturition is an inflammation process. Exaggerated inflammatory reactions in infection lead to preterm birth. Although nuclear factor kappa B (NF-κB) has been recognized as a classical transcription factor me...

    Authors: Wen-Jia Lei, Fan Zhang, Meng-Die Li, Fan Pan, Li-Jun Ling, Jiang-Wen Lu, Leslie Myatt, Kang Sun and Wang-Sheng Wang
    Citation: BMC Medicine 2024 22:432
    Content type: Research Published on:

  27. Individuals who have experienced severe traumatic events are estimated to have a post-traumatic stress disorder (PTSD) prevalence rate ranging from 10 to 50%, while those not affected by trauma exposure are of...

    Authors: Minlan Yuan, Lun Li, Hongru Zhu, Bo Zheng, Su Lui and Wei Zhang
    Citation: BMC Medicine 2024 22:431
    Content type: Research Published on:

  28. Several surgical options for degenerative lumbar spinal stenosis (LSS) are available, but current guidelines do not recommend which one should be prioritized. Although previous network meta-analyses (NMAs) hav...

    Authors: Lingxiao Chen, Bin Guan, David B. Anderson, Paulo H. Ferreira, Ralph Stanford, Paula R. Beckenkamp, James M. Van Gelder, Munkh-erdene Bayartai, Maja R. Radojčić, Jeremy C. T. Fairbank, Shiqing Feng, Hengxing Zhou and Manuela L. Ferreira
    Citation: BMC Medicine 2024 22:430
    Content type: Research Published on:

  29. Telomere length (TL), mitochondrial DNA copy number (mtDNAcn), and DNA methylation age (DNAmAge) are common aging biomarkers. However, research on the associations between these three markers at birth and subs...

    Authors: Zhenxian Jia, Feng Qiu, Yujie He, Huan Chen, Chenhui Yang, Hongxiu Liu, Tongzhang Zheng, Shunqing Xu, Shiqiong Wang and Yuanyuan Li
    Citation: BMC Medicine 2024 22:429
    Content type: Research Published on:

  30. Lazertinib is a potent, irreversible, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with significant efficacy in patients with EGFR T790M-mutated non-small cell lung can...

    Authors: Ji-Youn Han, Myung-Ju Ahn, Ki Hyeong Lee, Yun-Gyoo Lee, Dong-Wan Kim, Young Joo Min, Sang-We Kim, Eun Kyung Cho, Joo-Hang Kim, Gyeong-Won Lee, Sung Sook Lee, Na Mi Lee, Hyun Woo Jang, Heewon Han, Hyejoo Park, Jieon Lee…
    Citation: BMC Medicine 2024 22:428
    Content type: Research article Published on:

  31. Very few studies to date investigated the prospective association of changes in exposure to the food environment with cardiovascular disease (CVD) risk. We aim to explore if time-varying exposure to the food e...

    Authors: Maria Gabriela M. Pinho, Yvonne Koop, Joreintje D. Mackenbach, Jeroen Lakerveld, Mariana Simões, Roel Vermeulen, Alfred J. Wagtendonk, Ilonca Vaartjes and Joline W. J. Beulens
    Citation: BMC Medicine 2024 22:427
    Content type: Research Published on:

  32. S100β is a biomarker of astroglial damage, the level of which is significantly increased following brain injury. However, the characteristics of S100β and its association with prognosis in patients with acute ...

    Authors: Yang Qu, Hang Jin, Reziya Abuduxukuer, Shuang Qi, Xiang-Kun Si, Peng Zhang, Ke-Jia Zhang, Si-Ji Wang, Xiang-Yu Zheng, Yu Zhang, Jian-Hua Gao, Xian-Kun Zhang, Xiao-Dong Liu, Chun-Ying Li, Guang-Cai Li, Junmin Wang…
    Citation: BMC Medicine 2024 22:304
    Content type: Research article Published on:

  33. Accelerated biological aging has been verified to be a critical risk factor for a number of age-related diseases, but its role in dementia remained unclear. Whether it modified the effects of genetic factors w...

    Authors: Zirong Ye, Haoxiang Lang, Zishan Xie, Siyu Duan, Bihao Peng, Xiaochun Chen, Ya Fang and Jiawei Xin
    Citation: BMC Medicine 2024 22:425
    Content type: Research Published on:

  34. The Alcohol Use Disorders Identification Test (AUDIT) is commonly used in clinical settings to assess the severity of alcohol-related problems, with the effectiveness of alcohol reduction interventions varying...

    Authors: Shohei Dobashi, Kyoko Kawaida, Go Saito, Yukiko Owaki and Hisashi Yoshimoto
    Citation: BMC Medicine 2024 22:424
    Content type: Research Published on:

  36. Breast cancer (BC) is a complex disease with profound genomic aberrations. However, the underlying molecular disparity influenced by age and ethnicity remains elusive.

    Authors: Ji Yoon Lee, Ji Won Lee, Min Sung Chung, Jong Gwon Choi, Sung Hoon Sim, Hyo Jeong Kim, Jeong Eun Kim, Kyoung Eun Lee, Yeon Hee Park, Myoung Joo Kang, Mi Sun Ahn, Yee Soo Chae, Ji Hyun Park, Jee Hyun Kim, Gun Min Kim, Jae Ho Byun…
    Citation: BMC Medicine 2024 22:422
    Content type: Research Published on:

  37. Cell and gene therapy products (CGTPs) often receive accelerated approvals, lacking comprehensive long-term safety and efficacy data, which can raise significant safety concerns. This research aims to study th...

    Authors: Yuxin Cai, Lijuan Sui, Jingjing Wang, Weilin Qian, Yeheng Peng, Luyao Gong, Weijia Wu and Yuan Gao
    Citation: BMC Medicine 2024 22:421
    Content type: Research article Published on:

  38. Protein biomarkers may contribute to the identification of vulnerable subgroups for premature mortality. This study aimed to investigate the association of plasma proteins with all-cause and cause-specific mor...

    Authors: Hong Luo, Agnese Petrera, Stefanie M. Hauck, Wolfgang Rathmann, Christian Herder, Christian Gieger, Annika Hoyer, Annette Peters and Barbara Thorand
    Citation: BMC Medicine 2024 22:420
    Content type: Research Published on:

  39. Adults living with human immunodeficiency virus (ALWHIV) receiving antiretroviral therapy (ART) exhibit higher pneumococcal carriage prevalence than adults without HIV (HIV-). To assess factors influencing hig...

    Authors: Joseph Phiri, Lusako Sibale, Lukerensia Mlongoti, Ndaona Mitole, Alice Kusakala, Mercy Khwiya, Thokozani Kayembe, Edwin Lisimba, Prosperina Kapwata, Ken Malisita, Chrispin Chaguza, Daniela M. Ferreira, Deus Thindwa and Kondwani Jambo
    Citation: BMC Medicine 2024 22:419
    Content type: Research Published on:

  40. Metformin is a hypoglycaemic medication that has been proposed to treat or prevent preeclampsia. Combining national birth data from Scotland and Sweden, we investigated whether metformin used during pregnancy ...

    Authors: Hannah Gordon, Noor Salim, Stephen Tong, Susan Walker, Manarangi De Silva, Catherine Cluver, Parinaz Mehdipour, Richard Hiscock, Lauren Sutherland, Ann Doust, Lina Bergman, Anna-Karin Wikström, Anthea Lindquist, Susanne Hesselman and Roxanne Hastie
    Citation: BMC Medicine 2024 22:418
    Content type: Research Published on:

  41. The hearing health sector is an example of a health sector that is experiencing a period of rapid innovation driven by digital technologies. These innovations will impact the types of interventions and service...

    Authors: Isabelle Boisvert, Samantha Cruz Rivera, Jennifer Smith-Merry, Barbara Molony-Oates, Emily Kecman and Sarah E. Hughes
    Citation: BMC Medicine 2024 22:417
    Content type: Research Published on:

  42. A third of children born in England have at least one parent born outside the United Kingdom (UK), yet family migration history is infrequently studied as a social determinant of child health. We describe rate...

    Authors: Kate M. Lewis, Rachel Burns, Mario Cortina-Borja, Anja Heilmann, Alison Macfarlane, Selina Nath, Sarah M. Salway, Sonia Saxena, Nazmy Villarroel-Williams, Russell Viner and Pia Hardelid
    Citation: BMC Medicine 2024 22:416
    Content type: Research article Published on:

  44. The benefits of comprehensive geriatric assessment (CGA) are well established for hospital care but less so for primary care. Our primary objective was to assess the effect of two multifaceted interventions ba...

    Authors: Veronique Orcel, Leon Banh, Sylvie Bastuji-Garin, Vincent Renard, Emmanuelle Boutin, Amel Gouja, Philippe Caillet, Elena Paillaud, Etienne Audureau and Emilie Ferrat
    Citation: BMC Medicine 2024 22:414
    Content type: Research Published on:

  45. The use of digital health technologies to measure outcomes in clinical trials opens new opportunities as well as methodological challenges. Digital outcome measures may provide more sensitive and higher-freque...

    Authors: Mia S. Tackney, James R. Carpenter and Sofía S. Villar
    Citation: BMC Medicine 2024 22:413
    Content type: Review Published on:

  46. Action on smoking, obesity, excess alcohol, and physical inactivity in primary care is effective and cost-effective, but implementation is low. The aim was to examine the effectiveness of strategies to increas...

    Authors: Laura Heath, Richard Stevens, Brian D. Nicholson, Joseph Wherton, Min Gao, Caitriona Callan, Simona Haasova and Paul Aveyard
    Citation: BMC Medicine 2024 22:412
    Content type: Research article Published on:

  47. Evidence suggests that insulin resistance (IR) is an autonomous risk factor for cardiovascular disease (CVD). Nevertheless, the association between estimated glucose disposal rate (eGDR), a novel indicator of ...

    Authors: Juan Peng, Yan Zhang, Yiqun Zhu, Weilin Chen, Li Chen, Fangyu Ma, Bin Yi and Zhijun Huang
    Citation: BMC Medicine 2024 22:411
    Content type: Research article Published on:

  48. Conflicting results comparing bivalirudin versus heparin anticoagulation in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI), in part...

    Authors: Jia Liao, Miaohan Qiu, Xiaojian Feng, Kui Chen, Dingbao Zhang, Yuncheng Zou, Xiaohui Zheng, Gang Zhao, Nailiang Tian, Zeqi Zheng, Xiaoping Peng, Qing Yang, Zhenyang Liang, Yi Li, Yaling Han and Gregg W. Stone
    Citation: BMC Medicine 2024 22:410
    Content type: Research Published on:

  49. Authors: Sean W. D. Carter, Erin L. Fee, Haruo Usuda, Gokce Oguz, Adaikalavan Ramasamy, Zubair Amin, Biswas Agnihotri, Qin Wei, Liu Xiawen, Tsukasa Takahashi, Yuki Takahashi, Hideyuki Ikeda, Yusaku Kumagai, Yuya Saito, Masatoshi Saito, Citra Mattar…
    Citation: BMC Medicine 2024 22:409
    Content type: Correction Published on:

    The original article was published in BMC Medicine 2024 22:338

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