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  1. The renal risk score (RRS) is a useful tool to predict end-stage renal disease (ESRD) in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The current study aimed to validat...

    Authors: Rui-Xue Wang, Jin-Wei Wang, Zhi-Ying Li, Su-Fang Chen, Xiao-Juan Yu, Su-Xia Wang, Fan Zhang, Zu-Ying Xiong, Shu-Hong Bi, Yue Wang, Ming-Hui Zhao and Min Chen
    Citation: BMC Medicine 2023 21:45
  2. Neonatal intensive care unit (NICU) admission among term neonates is a rare event. The aim of this study was to study the association of the NICU admission of term neonates on the risk of long-term childhood m...

    Authors: Shahar Talisman, Joshua Guedalia, Rivka Farkash, Tehila Avitan, Naama Srebnik, Yair Kasirer, Michael S. Schimmel, Donia Ghanem, Ron Unger and Sorina Grisaru Granovsky
    Citation: BMC Medicine 2023 21:44
  3. Numerous intrauterine factors may affect the offspring’s growth during childhood. We aimed to explore if maternal and paternal prenatal lipid, apolipoprotein (apo)B and apoA1 levels are associated with offspri...

    Authors: Linn K. L. Øyri, Jacob J. Christensen, Sylvain Sebert, Magne Thoresen, Trond M. Michelsen, Stine M. Ulven, Hilde K. Brekke, Kjetil Retterstøl, Anne Lise Brantsæter, Per Magnus, Martin P. Bogsrud and Kirsten B. Holven
    Citation: BMC Medicine 2023 21:43
  4. Arteriosclerosis and atherosclerosis are closely related with cardiovascular disease (CVD) risk. Remnant cholesterol (RC) could predict CVD. However, its effect on joint arteriosclerosis and atherosclerosis pr...

    Authors: Zhiyuan Wu, Jinqi Wang, Haiping Zhang, Huiying Pan, Zhiwei Li, Yue Liu, Xinlei Miao, Ze Han, Xiaoping Kang, Xia Li, Xiuhua Guo, Lixin Tao and Wei Wang
    Citation: BMC Medicine 2023 21:42
  5. Individuals with mental health problems have been shown to have an increased risk of cardiovascular disorder (CVD), but little is known about the risk of early-onset CVD among those with intellectual disabilit...

    Authors: Hui Wang, Priscilla Ming Yi Lee, Jun Zhang, Katrine Svendsen, Fei Li and Jiong Li
    Citation: BMC Medicine 2023 21:41
  6. The ability of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) to decrease certain microvascular events has called for the investigation of GLP-1 RAs against diabetic retinopathy (DR), but the evidence i...

    Authors: Deqiang Zheng, Ning Li, Rui Hou, Xiaoyu Zhang, Lijuan Wu, Jan Sundquist, Kristina Sundquist and Jianguang Ji
    Citation: BMC Medicine 2023 21:40
  7. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that is accompanied by muscle weakness and muscle atrophy, typically resulting in death within 3–5 years from the disease occurrence. Though ...

    Authors: Bin Liu, Linshuoshuo Lyu, Wenkai Zhou, Jie Song, Ding Ye, Yingying Mao, Guo-Bo Chen and Xiaohui Sun
    Citation: BMC Medicine 2023 21:39
  8. Cancer cells have developed molecular strategies to cope with evolutionary stressors in the dynamic tumor microenvironment. Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC1α) is a metabolic rh...

    Authors: Ki Cheong Park, Jung Min Kim, Sang Yong Kim, Seok-Mo Kim, Jin Hong Lim, Min Ki Kim, Sungsoon Fang, Yonjung Kim, Gordon B. Mills, Sung Hoon Noh and Jae-Ho Cheong
    Citation: BMC Medicine 2023 21:38
  9. Extensive evidence links higher body mass index (BMI) to higher odds of depression in people of European ancestry. However, our understanding of the relationship across different settings and ancestries is lim...

    Authors: Jessica O’Loughlin, Francesco Casanova, Zammy Fairhurst-Hunter, Amanda Hughes, Jack Bowden, Edward R. Watkins, Rachel M. Freathy, Iona Y. Millwood, Kuang Lin, Zhengming Chen, Liming Li, Jun Lv, Robin G. Walters, Laura D. Howe, Karoline Kuchenbaecker and Jessica Tyrrell
    Citation: BMC Medicine 2023 21:37
  10. Crimean-Congo hemorrhagic fever (CCHF) is a widespread disease transmitted to humans and livestock animals through the bite of infected ticks or close contact with infected persons’ blood, organs, or other bod...

    Authors: Rahat Alam, Abdus Samad, Foysal Ahammad, Suza Mohammad Nur, Ahad Amer Alsaiari, Raihan Rahman Imon, Md. Enamul Kabir Talukder, Zulkar Nain, Md. Mashiar Rahman, Farhan Mohammad and Tomasz M. Karpiński
    Citation: BMC Medicine 2023 21:36
  11. Congenital heart diseases (CHDs) remain a significant cause of infant morbidity and mortality. Epidemiological studies have explored maternal risk factors for offspring CHDs, but few have used genetic epidemio...

    Authors: Kurt Taylor, Robyn E. Wootton, Qian Yang, Sam Oddie, John Wright, Tiffany C. Yang, Maria Magnus, Ole A. Andreassen, Maria Carolina Borges, Massimo Caputo and Deborah A. Lawlor
    Citation: BMC Medicine 2023 21:35
  12. The current food system in England promotes a population diet that is high in fat, sugar and salt (HFSS). To address this, the UK government has implemented legislation to restrict the promotion of HFSS produc...

    Authors: Sarah Muir, Preeti Dhuria, Emma Roe, Wendy Lawrence, Janis Baird and Christina Vogel
    Citation: BMC Medicine 2023 21:33
  13. Long-term exposure to air pollution has been associated with the onset and progression of kidney diseases, but the association between short-term exposure to air pollution and mortality of kidney diseases has ...

    Authors: Miao Cai, Jing Wei, Shiyu Zhang, Wei Liu, Lijun Wang, Zhengmin Qian, Hualiang Lin, Echu Liu, Stephen Edward McMillin, Yu Cao and Peng Yin
    Citation: BMC Medicine 2023 21:32
  14. Concurrent atherogenic dyslipidemia and elevated inflammation are commonly observed in overt hyperglycemia and have long been proposed to contribute to diabetogenesis. However, the temporal relationship betwee...

    Authors: Yulong Lan, Guanzhi Chen, Dan Wu, Xiong Ding, Zegui Huang, Xianxuan Wang, Lois Balmer, Xingang Li, Manshu Song, Wei Wang, Shouling Wu and Youren Chen
    Citation: BMC Medicine 2023 21:31
  15. Colorectal cancer (CRC) screening reduces all-cause and CRC-related mortality. New research demonstrates that the faecal haemoglobin concentration (f-Hb) may indicate the presence of other serious diseases not...

    Authors: Lasse Kaalby, Ulrik Deding, Issam Al-Najami, Gabriele Berg-Beckhoff, Thomas Bjørsum-Meyer, Tinne Laurberg, Aasma Shaukat, Robert J. C. Steele, Anastasios Koulaouzidis, Morten Rasmussen, Morten Kobaek-Larsen and Gunnar Baatrup
    Citation: BMC Medicine 2023 21:29
  16. Currently in the United Kingdom, cardiovascular disease (CVD) risk assessment is based on the QRISK3 score, in which 10% 10-year CVD risk indicates clinical intervention. However, this benchmark has limited ef...

    Authors: Rachel Marjorie Wei Wen Tseng, Tyler Hyungtaek Rim, Eduard Shantsila, Joseph K. Yi, Sungha Park, Sung Soo Kim, Chan Joo Lee, Sahil Thakur, Simon Nusinovici, Qingsheng Peng, Hyeonmin Kim, Geunyoung Lee, Marco Yu, Yih-Chung Tham, Ameet Bakhai, Paul Leeson…
    Citation: BMC Medicine 2023 21:28
  17. Salivary amylase, encoded by the AMY1 gene, initiate the digestion of starch. Whether starch intake or AMY1 copy number is related to disease risk is currently rather unknown. The aim was to investigate the assoc...

    Authors: Huiping Li, Yan Borné, Yaogang Wang and Emily Sonestedt
    Citation: BMC Medicine 2023 21:27
  18. The COVID-19 pandemic caused rapid changes in primary care delivery in the UK, with concerns that certain groups of the population may have faced increased barriers to access. This study assesses the impact of...

    Authors: Alice McGreevy, Marina Soley-Bori, Mark Ashworth, Yanzhong Wang, Emma Rezel-Potts, Stevo Durbaba, Hiten Dodhia and Julia Fox-Rushby
    Citation: BMC Medicine 2023 21:26
  19. Predicting the likely size of future SARS-CoV-2 waves is necessary for public health planning. In England, voluntary “plan B” mitigation measures were introduced in December 2021 including increased home worki...

    Authors: Ellen Brooks-Pollock, Kate Northstone, Lorenzo Pellis, Francesca Scarabel, Amy Thomas, Emily Nixon, David A. Matthews, Vicky Bowyer, Maria Paz Garcia, Claire J. Steves, Nicholas J. Timpson and Leon Danon
    Citation: BMC Medicine 2023 21:25
  20. Retinal structural abnormalities have been found to serve as biomarkers for cardiovascular disease (CVD). However, the association between retinal nerve fiber layer (RNFL) thickness and the incidence of CVD ev...

    Authors: Yanping Chen, Yixiong Yuan, Shiran Zhang, Shaopeng Yang, Junyao Zhang, Xiao Guo, Wenyong Huang, Zhuoting Zhu, Mingguang He and Wei Wang
    Citation: BMC Medicine 2023 21:24
  21. Common pregnancy and perinatal complications are associated with offspring cardiometabolic risk factors. These complications may influence multiple metabolic traits in the offspring and these associations migh...

    Authors: Ahmed Elhakeem, Justiina Ronkainen, Toby Mansell, Katherine Lange, Tuija M. Mikkola, Binisha H. Mishra, Rama J. Wahab, Tim Cadman, Tiffany Yang, David Burgner, Johan G. Eriksson, Marjo-Riitta Järvelin, Romy Gaillard, Vincent W. V. Jaddoe, Terho Lehtimäki, Olli T. Raitakari…
    Citation: BMC Medicine 2023 21:23
  22. Taxation increases which reduce the affordability of alcohol are expected to reduce mortality inequalities. A recent taxation increase in Lithuania offers the unique possibility to test this hypothesis.

    Authors: Jakob Manthey, Domantas Jasilionis, Huan Jiang, Olga Meščeriakova, Janina Petkevičienė, Ričardas Radišauskas, Mindaugas Štelemėkas and Jürgen Rehm
    Citation: BMC Medicine 2023 21:22
  23. The number of medications prescribed during pregnancy has increased over the past few decades. Few studies have described the prevalence of multiple medication use among pregnant women. This study aims to desc...

    Authors: Anuradhaa Subramanian, Amaya Azcoaga-Lorenzo, Astha Anand, Katherine Phillips, Siang Ing Lee, Neil Cockburn, Adeniyi Francis Fagbamigbe, Christine Damase-Michel, Christopher Yau, Colin McCowan, Dermot O’Reilly, Gillian Santorelli, Holly Hope, Jonathan I. Kennedy, Kathryn M. Abel, Kelly-Ann Eastwood…
    Citation: BMC Medicine 2023 21:21
  24. Visit-to-visit body weight variability (BWV), pulse rate variability (PRV), and blood pressure variability (BPV) have been respectively linked to multiple health outcomes. The associations of the combination o...

    Authors: Hui Chen, Tianjing Zhou, Shaowei Wu, Yaying Cao, Geng Zong and Changzheng Yuan
    Citation: BMC Medicine 2023 21:20
  25. Beginning May 7, 2022, multiple nations reported an unprecedented surge in monkeypox cases. Unlike past outbreaks, differences in affected populations, transmission mode, and clinical characteristics have been...

    Authors: Amanda Bleichrodt, Sushma Dahal, Kevin Maloney, Lisa Casanova, Ruiyan Luo and Gerardo Chowell
    Citation: BMC Medicine 2023 21:19
  26. Programmed cell death protein-1 (PD-1) blockade therapies have demonstrated efficacy in nasopharyngeal carcinoma (NPC). Thyroid dysfunction is among the most common immune-related adverse events. This study ai...

    Authors: Zi-Hang Chen, Wei-Hong Zheng, Chen-Fei Wu, Jia Kou, Xing-Li Yang, Li Lin, Jia-Wei Lv, Ying Sun and Guan-Qun Zhou
    Citation: BMC Medicine 2023 21:18
  27. Rapid postnatal growth may result from exposure in utero or early life to adverse conditions and has been associated with diseases later in life and, in particular, with childhood obesity. DNA methylation, interf...

    Authors: Rossella Alfano, Daniela Zugna, Henrique Barros, Mariona Bustamante, Leda Chatzi, Akram Ghantous, Zdenko Herceg, Pekka Keski-Rahkonen, Theo M. de Kok, Tim S Nawrot, Caroline L Relton, Oliver Robinson, Theano Roumeliotaki, Augustin Scalbert, Martine Vrijheid, Paolo Vineis…
    Citation: BMC Medicine 2023 21:17
  28. The pathogenesis of diabetic kidney disease (DKD) is complex, involving metabolic and hemodynamic factors. Although DKD has been established as a heritable disorder and several genetic studies have been conduc...

    Authors: Heejin Jin, Ye An Kim, Young Lee, Seung-hyun Kwon, Ah Ra Do, Sujin Seo, Sungho Won and Je Hyun Seo
    Citation: BMC Medicine 2023 21:16
  29. Authors: Meichen Li, Jing Chen, Baishen Zhang, Juan Yu, Na Wang, Delan Li, Yang Shao, Dongqin Zhu, Chuqiao Liang, Yutong Ma, Qiuxiang Ou, Xue Hou and Likun Chen
    Citation: BMC Medicine 2023 21:15

    The original article was published in BMC Medicine 2022 20:398

  30. Personalised medicine is a medical model that aims to provide tailor-made prevention and treatment strategies for defined groups of individuals. The concept brings new challenges to the translational step, bot...

    Authors: Vibeke Fosse, Emanuela Oldoni, Florence Bietrix, Alfredo Budillon, Evangelos P. Daskalopoulos, Maddalena Fratelli, Björn Gerlach, Peter M. A. Groenen, Sabine M. Hölter, Julia M. L. Menon, Ali Mobasheri, Nikki Osborne, Merel Ritskes-Hoitinga, Bettina Ryll, Elmar Schmitt, Anton Ussi…
    Citation: BMC Medicine 2023 21:14
  31. Ethnic minority groups in England have been disproportionately affected by the COVID-19 pandemic and have lower vaccination rates than the White British population. We examined whether ethnic differences in CO...

    Authors: Matthew L. Bosworth, Tamanna Ahmed, Tim Larsen, Luke Lorenzi, Jasper Morgan, Raghib Ali, Peter Goldblatt, Nazrul Islam, Kamlesh Khunti, Veena Raleigh, Daniel Ayoubkhani, Neil Bannister, Myer Glickman and Vahé Nafilyan
    Citation: BMC Medicine 2023 21:13
  32. Poor social support during pregnancy has been linked to inflammation and adverse pregnancy and childhood health outcomes. Placental epigenetic alterations may underlie these links but are still unknown in humans.

    Authors: Markos Tesfaye, Jing Wu, Richard J. Biedrzycki, Katherine L. Grantz, Paule Joseph and Fasil Tekola-Ayele
    Citation: BMC Medicine 2023 21:12
  33. Rezivertinib (BPI-7711) is a novel third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). This phase IIa study was part of a phase I/IIa study (NCT03386955), aimed to evaluat...

    Authors: Yuankai Shi, Jianying Zhou, Yanqiu Zhao, Bo Zhu, Liangming Zhang, Xingya Li, Jian Fang, Jianhua Shi, Zhixiang Zhuang, Sheng Yang, Donglin Wang, Huiqing Yu, Longzhen Zhang, Rongsheng Zheng, Michael Greco and Tingting Wang
    Citation: BMC Medicine 2023 21:11
  34. The prediction of long-term mortality following acute illness can be unreliable for older patients, inhibiting the delivery of targeted clinical interventions. The difficulty plausibly arises from the complex,...

    Authors: Alex Tsui, Petru-Daniel Tudosiu, Mikael Brudfors, Ashwani Jha, Jorge Cardoso, Sebastien Ourselin, John Ashburner, Geraint Rees, Daniel Davis and Parashkev Nachev
    Citation: BMC Medicine 2023 21:10
  35. Understanding the relationship between chronic pain conditions and suicidal behavior—suicide attempt, other intentional self-harm, and death by suicide—is imperative for suicide prevention efforts. Although ch...

    Authors: C. Chen, E. Pettersson, A. G. Summit, K. Boersma, Z. Chang, R. Kuja-Halkola, P. Lichtenstein and P. D. Quinn
    Citation: BMC Medicine 2023 21:9
  36. Adverse childhood life events are associated with increased risks of hypertension, ischemic heart disease, and stroke later in life. Limited evidence also suggests that stress in adulthood may increase the ris...

    Authors: Hua Chen, Imre Janszky, Mikael Rostila, Dang Wei, Fen Yang, Jiong Li and Krisztina D. László
    Citation: BMC Medicine 2023 21:8
  37. Perioperative neurocognitive disorders (PND) with a high incidence frequently occur in elderly surgical patients closely associated with prolonged anesthesia-induced neurotoxicity. The neuromorphopathological ...

    Authors: Feng Xu, Linlin Han, Yafeng Wang, Daling Deng, Yuanyuan Ding, Shuai Zhao, Qingtong Zhang, Lulin Ma and Xiangdong Chen
    Citation: BMC Medicine 2023 21:7
  38. Immune checkpoint inhibitor (ICI) therapy combined with conventional therapies is being broadly applied in non-small cell lung cancer (NSCLC) patients. However, the risk of interstitial pneumonitis (IP) follow...

    Authors: Xue-Jun Guo, Xiao-Ting Cai, Zi-Xuan Rong, Yan-Pei Zhang, Yu-Xiang Wen, Xue Bai, Jian Wang, Qiang John Fu, Ze-Qin Guo, Li-Li Long, Si-Cong Ma, Xin-Ran Tang, Li Liu, Jian Guan, Zhong-Yi Dong and De-Hua Wu
    Citation: BMC Medicine 2023 21:6
  39. Observational studies have linked childhood obesity with elevated risk of colorectal cancer; however, it is unclear if this association is causal or independent from the effects of obesity in adulthood on colo...

    Authors: Nikos Papadimitriou, Caroline J. Bull, Mazda Jenab, David J. Hughes, Joshua A. Bell, Eleanor Sanderson, Nicholas J. Timpson, George Davey Smith, Demetrius Albanes, Peter T. Campbell, Sébastien Küry, Loic Le Marchand, Cornelia M. Ulrich, Kala Visvanathan, Jane C. Figueiredo, Polly A. Newcomb…
    Citation: BMC Medicine 2023 21:5
  40. Metabolic-associated fatty liver disease (MAFLD) encompasses diverse disease groups with potentially heterogeneous clinical outcomes. We investigated the risk of all-cause and disease-specific mortality in MAF...

    Authors: Goh Eun Chung, Su Jong Yu, Jeong-Ju Yoo, Yuri Cho, Kyu-na Lee, Dong Wook Shin, Donghee Kim, Yoon Jun Kim, Jung-Hwan Yoon, Kyungdo Han and Eun Ju Cho
    Citation: BMC Medicine 2023 21:4
  41. Approximately 10% of stage I colorectal cancer (CRC) patients experience unfavorable clinical outcomes after surgery. However, little is known about the subset of stage I patients who are predisposed to high r...

    Authors: Qingbin Wu, Pengju Chen, Chi Shu, Lin Chen, Zechuan Jin, Jun Huang, Xin Wang, Xue Li, Mingtian Wei, Tinghan Yang, Xiangbing Deng, Aiwen Wu, Yazhou He and Ziqiang Wang
    Citation: BMC Medicine 2023 21:3
  42. HL-085 is a selective, orally administered MEK1/2 inhibitor. We aimed to evaluate the safety and efficacy of HL-085 in patients with advanced melanoma harboring NRAS mutations.

    Authors: Xuan Wang, Zhiguo Luo, Jing Chen, Yu Chen, Dongmei Ji, Li Fan, Ling Chen, Qian Zhao, Pei Hu, Peng Sun, Zhongwei Jia, Jun Guo and Lu Si
    Citation: BMC Medicine 2023 21:2
  43. The coronavirus disease 2019 (COVID-19) disproportionately affects minority populations in the USA. Sweden — like other Nordic countries — have less income and wealth inequality but lacks data on the socioecon...

    Authors: Max Bell, Maria-Pia Hergens, Stefan Fors, Per Tynelius, Antonio Ponce de Leon and Anton Lager
    Citation: BMC Medicine 2023 21:1
  44. Prenatal alcohol exposure (PAE) affects embryonic development, causing a variable fetal alcohol spectrum disorder (FASD) phenotype with neuronal disorders and birth defects. We hypothesize that early alcohol-i...

    Authors: P. Auvinen, J. Vehviläinen, H. Marjonen, V. Modhukur, J. Sokka, E. Wallén, K. Rämö, L. Ahola, A. Salumets, T. Otonkoski, H. Skottman, M. Ollikainen, R. Trokovic, H. Kahila and N. Kaminen-Ahola
    Citation: BMC Medicine 2022 20:495
  45. This trial aimed to analyse the safety, effectiveness and transcriptomic characteristics of neoadjuvant toripalimab plus chemotherapy in II–III non-small-cell lung cancer (NSCLC).

    Authors: Xinsheng Zhu, Liangdong Sun, Nan Song, Wenxin He, Boxiong Xie, Junjie Hu, Jing Zhang, Jie Yang, Jie Dai, Dongliang Bian, Haoran Xia, Fenghuan Sun, Anwen Xiong, Jie Luo, Lele Zhang, Huansha Yu…
    Citation: BMC Medicine 2022 20:493
  46. Obesity and related co-morbidities represent a major health challenge nowadays, with a rapidly increasing incidence worldwide. The gut microbiome has recently emerged as a key modifier of human health that can...

    Authors: Monica Barone, Silvia Garelli, Simone Rampelli, Alessandro Agostini, Silke Matysik, Federica D’Amico, Sabrina Krautbauer, Roberta Mazza, Nicola Salituro, Flaminia Fanelli, Patricia Iozzo, Yolanda Sanz, Marco Candela, Patrizia Brigidi, Uberto Pagotto and Silvia Turroni
    Citation: BMC Medicine 2022 20:500
  47. Pyrotinib (an irreversible pan-ErbB inhibitor) plus capecitabine has survival benefits and acceptable tolerability in patients with HER2-positive metastatic breast cancer. We further assessed addition of pyrot...

    Authors: Jiong Wu, Zefei Jiang, Zhenzhen Liu, Benlong Yang, Hongjian Yang, Jinhai Tang, Kun Wang, Yunjiang Liu, Haibo Wang, Peifen Fu, Shuqun Zhang, Qiang Liu, Shusen Wang, Jian Huang, Chuan Wang, Shu Wang…
    Citation: BMC Medicine 2022 20:498
  48. The pathogenesis of immunoglobulin G4-related disease (IgG4-RD) remains unclear. IgG4-RD often mimics other diseases, including pancreatic cancer (PC) and Sjogren’s syndrome (SS), which may easily lead to misd...

    Authors: Songxin Yan, Yu Peng, Ziyan Wu, Linlin Cheng, Haolong Li, Honglin Xu, Yuan Huang, Wen Zhang and Yongzhe Li
    Citation: BMC Medicine 2022 20:497